DCAF4L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)8.39611258
2DNA methylation involved in gamete generation (GO:0043046)8.20448600
3chromosome organization involved in meiosis (GO:0070192)8.09537341
4male meiosis I (GO:0007141)7.94236775
5synaptonemal complex assembly (GO:0007130)7.25489370
6male meiosis (GO:0007140)7.08025937
7synaptonemal complex organization (GO:0070193)6.56775341
8meiosis I (GO:0007127)6.49914613
9positive regulation of meiosis (GO:0045836)6.23931545
10meiotic nuclear division (GO:0007126)6.18495162
11resolution of meiotic recombination intermediates (GO:0000712)6.02763634
12DNA synthesis involved in DNA repair (GO:0000731)5.82369016
13positive regulation of meiotic cell cycle (GO:0051446)5.80933943
14gene silencing by RNA (GO:0031047)5.76839148
15negative regulation of meiosis (GO:0045835)5.68378611
16sister chromatid cohesion (GO:0007062)5.66474569
17meiotic cell cycle process (GO:1903046)5.55324440
18meiotic chromosome segregation (GO:0045132)5.18760540
19mitotic sister chromatid cohesion (GO:0007064)5.18125054
20oogenesis (GO:0048477)4.93253999
21meiotic cell cycle (GO:0051321)4.85182158
22mitotic chromosome condensation (GO:0007076)4.83170670
23regulation of meiosis (GO:0040020)4.52653725
24female gamete generation (GO:0007292)4.48113827
25DNA replication checkpoint (GO:0000076)4.47475665
26regulation of meiotic cell cycle (GO:0051445)4.37308956
27regulation of DNA endoreduplication (GO:0032875)4.19269156
28proteasome assembly (GO:0043248)3.92182161
29CENP-A containing nucleosome assembly (GO:0034080)3.83877999
30binding of sperm to zona pellucida (GO:0007339)3.79928991
31negative regulation of meiotic cell cycle (GO:0051447)3.79306299
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.76624017
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76624017
34chromatin remodeling at centromere (GO:0031055)3.75242225
35reciprocal DNA recombination (GO:0035825)3.73823278
36reciprocal meiotic recombination (GO:0007131)3.73823278
37nuclear pore complex assembly (GO:0051292)3.71706830
38histone exchange (GO:0043486)3.68149340
39regulation of histone H3-K9 methylation (GO:0051570)3.62776850
40DNA methylation (GO:0006306)3.52704970
41DNA alkylation (GO:0006305)3.52704970
42gene silencing (GO:0016458)3.46802963
43sex differentiation (GO:0007548)3.46454556
44nuclear pore organization (GO:0006999)3.40040001
45DNA replication initiation (GO:0006270)3.35717400
46mitotic metaphase plate congression (GO:0007080)3.33387219
47telomere maintenance via semi-conservative replication (GO:0032201)3.32948056
48negative regulation of gene silencing (GO:0060969)3.23730125
49oocyte maturation (GO:0001556)3.21678573
50formation of translation preinitiation complex (GO:0001731)3.10336454
51ncRNA 3-end processing (GO:0043628)3.10181118
52chromosome organization (GO:0051276)3.07914695
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.06885944
54DNA catabolic process, exonucleolytic (GO:0000738)3.05214729
55DNA replication-independent nucleosome assembly (GO:0006336)3.05126152
56DNA replication-independent nucleosome organization (GO:0034724)3.05126152
57histone H3-K9 demethylation (GO:0033169)3.04836199
58regulation of centriole replication (GO:0046599)3.04015593
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03037119
60germ cell development (GO:0007281)3.02544892
61centriole replication (GO:0007099)2.98493879
62regulation of centrosome cycle (GO:0046605)2.97980880
63DNA strand elongation involved in DNA replication (GO:0006271)2.97380104
64centriole assembly (GO:0098534)2.96276877
65histone H2A acetylation (GO:0043968)2.95869460
66DNA strand elongation (GO:0022616)2.93335095
67N-terminal protein amino acid acetylation (GO:0006474)2.93293508
68ribosomal small subunit assembly (GO:0000028)2.92888133
69metaphase plate congression (GO:0051310)2.90032666
70protein localization to chromosome (GO:0034502)2.88145401
71sperm-egg recognition (GO:0035036)2.86692732
72regulation of chromosome segregation (GO:0051983)2.85173935
73telomere maintenance via recombination (GO:0000722)2.84962680
74attachment of spindle microtubules to kinetochore (GO:0008608)2.84154915
75mitotic recombination (GO:0006312)2.77985040
76folic acid transport (GO:0015884)2.77565244
77protein localization to kinetochore (GO:0034501)2.77555200
78protein localization to chromosome, centromeric region (GO:0071459)2.76469780
79chromosome segregation (GO:0007059)2.74374174
80intra-S DNA damage checkpoint (GO:0031573)2.74000354
81spermatid development (GO:0007286)2.73393604
82nuclear division (GO:0000280)2.71210763
83kinetochore organization (GO:0051383)2.70277072
84DNA methylation or demethylation (GO:0044728)2.67916144
85nucleotide transmembrane transport (GO:1901679)2.67582900
86DNA packaging (GO:0006323)2.67538848
87DNA biosynthetic process (GO:0071897)2.66561942
88nucleotide-excision repair, DNA gap filling (GO:0006297)2.66506499
89negative regulation of nuclear division (GO:0051784)2.66456175
90microtubule depolymerization (GO:0007019)2.65523535
91pore complex assembly (GO:0046931)2.64831767
92chromosome condensation (GO:0030261)2.64262998
93positive regulation of translational initiation (GO:0045948)2.60580473
94organelle fission (GO:0048285)2.56977189
95blastocyst development (GO:0001824)2.55910193
96mitotic sister chromatid segregation (GO:0000070)2.51137216
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50273562
98piRNA metabolic process (GO:0034587)12.5815472
99regulation of meiosis I (GO:0060631)11.1946913
100synapsis (GO:0007129)10.2741407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.98199562
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.79084104
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59552711
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36818636
5IGF1R_20145208_ChIP-Seq_DFB_Human3.00060341
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.80667569
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68950338
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60309180
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57987406
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57743186
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57743186
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57743186
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.51643969
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.49214552
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39286700
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.36551448
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33697783
18VDR_22108803_ChIP-Seq_LS180_Human2.27927660
19ZNF274_21170338_ChIP-Seq_K562_Hela2.25988431
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.20657179
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19122219
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17295719
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12098789
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05447754
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.02408300
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02058223
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01235828
28AR_21909140_ChIP-Seq_LNCAP_Human2.01127473
29DCP1A_22483619_ChIP-Seq_HELA_Human1.99996355
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.92788165
31VDR_23849224_ChIP-Seq_CD4+_Human1.92540052
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89944372
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87824503
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84364761
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.77895399
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.77749753
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74376134
38CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69608810
39FOXP3_21729870_ChIP-Seq_TREG_Human1.68216163
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67680251
41TTF2_22483619_ChIP-Seq_HELA_Human1.66201254
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63511857
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63448297
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62962135
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59269419
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56688836
47ELK1_19687146_ChIP-ChIP_HELA_Human1.56444373
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53251026
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.49301801
50GABP_19822575_ChIP-Seq_HepG2_Human1.48562334
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39929740
52IRF1_19129219_ChIP-ChIP_H3396_Human1.39773655
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38912950
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38052366
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33281843
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27305569
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.22883648
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22713725
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21092698
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18204310
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15631734
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13450024
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12211147
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11142284
65EZH2_22144423_ChIP-Seq_EOC_Human1.10472264
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10465360
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.08643180
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06837146
69MYC_18940864_ChIP-ChIP_HL60_Human1.04794583
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01372090
71HTT_18923047_ChIP-ChIP_STHdh_Human1.01135098
72EWS_26573619_Chip-Seq_HEK293_Human1.01046376
73XRN2_22483619_ChIP-Seq_HELA_Human0.98527071
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97979698
75KDM5A_27292631_Chip-Seq_BREAST_Human0.95255269
76TAF15_26573619_Chip-Seq_HEK293_Human0.94371328
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92604953
78TP53_22573176_ChIP-Seq_HFKS_Human0.91172332
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.89205600
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89205600
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88103151
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.87619241
83GATA3_26560356_Chip-Seq_TH1_Human0.86178024
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85470383
85ZNF263_19887448_ChIP-Seq_K562_Human0.85088722
86RNF2_27304074_Chip-Seq_NSC_Mouse0.83518628
87TFEB_21752829_ChIP-Seq_HELA_Human0.83105677
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82763578
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81323002
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80418490
91HOXB7_26014856_ChIP-Seq_BT474_Human0.77145239
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76853888
93ETV1_20927104_ChIP-Seq_GIST48_Human0.74849890
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74343035
95FUS_26573619_Chip-Seq_HEK293_Human0.72683212
96* ER_23166858_ChIP-Seq_MCF-7_Human0.72588758
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.71228109
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.71060818
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71052688
100PHF8_20622853_ChIP-Seq_HELA_Human0.69561037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.60794213
2MP0008058_abnormal_DNA_repair4.57164000
3MP0003693_abnormal_embryo_hatching3.91201908
4MP0002210_abnormal_sex_determination3.71664155
5MP0001929_abnormal_gametogenesis3.52677527
6MP0010368_abnormal_lymphatic_system3.46797846
7MP0003718_maternal_effect3.19383807
8MP0004957_abnormal_blastocyst_morpholog3.18709799
9MP0010094_abnormal_chromosome_stability3.18349538
10MP0004147_increased_porphyrin_level3.05375760
11MP0002139_abnormal_hepatobiliary_system3.01822478
12MP0001145_abnormal_male_reproductive2.81838393
13MP0000653_abnormal_sex_gland2.75818271
14MP0003698_abnormal_male_reproductive2.67833584
15MP0008057_abnormal_DNA_replication2.62231097
16MP0003111_abnormal_nucleus_morphology2.30054427
17MP0003077_abnormal_cell_cycle2.28161636
18MP0009697_abnormal_copulation2.25286803
19MP0002160_abnormal_reproductive_system2.18941172
20MP0008932_abnormal_embryonic_tissue1.97796886
21MP0008995_early_reproductive_senescence1.82143108
22MP0002161_abnormal_fertility/fecundity1.78507368
23MP0005360_urolithiasis1.73867148
24MP0005410_abnormal_fertilization1.73836909
25MP0001730_embryonic_growth_arrest1.70451830
26MP0003699_abnormal_female_reproductive1.65622329
27MP0003186_abnormal_redox_activity1.62939126
28MP0001119_abnormal_female_reproductive1.60540890
29MP0005085_abnormal_gallbladder_physiolo1.59887814
30MP0005365_abnormal_bile_salt1.58207497
31MP0003646_muscle_fatigue1.53132621
32MP0006292_abnormal_olfactory_placode1.51785157
33MP0000678_abnormal_parathyroid_gland1.46738630
34MP0010307_abnormal_tumor_latency1.43558440
35MP0003806_abnormal_nucleotide_metabolis1.42676662
36MP0003890_abnormal_embryonic-extraembry1.42552093
37MP0008007_abnormal_cellular_replicative1.42021030
38MP0003868_abnormal_feces_composition1.39942498
39MP0005389_reproductive_system_phenotype1.30094199
40MP0003786_premature_aging1.29670846
41MP0006035_abnormal_mitochondrial_morpho1.28478830
42MP0008260_abnormal_autophagy1.25770646
43MP0003959_abnormal_lean_body1.23759579
44MP0005174_abnormal_tail_pigmentation1.21678384
45MP0001666_abnormal_nutrient_absorption1.18318602
46MP0001764_abnormal_homeostasis1.17952451
47MP0003183_abnormal_peptide_metabolism1.13704450
48MP0000350_abnormal_cell_proliferation1.08181408
49MP0005395_other_phenotype1.06641204
50MP0001672_abnormal_embryogenesis/_devel1.06409881
51MP0005380_embryogenesis_phenotype1.06409881
52MP0002084_abnormal_developmental_patter1.06326800
53MP0005645_abnormal_hypothalamus_physiol1.03749867
54MP0003950_abnormal_plasma_membrane1.03175642
55MP0001697_abnormal_embryo_size1.02105953
56MP0004233_abnormal_muscle_weight1.02003069
57MP0005332_abnormal_amino_acid1.01775299
58MP0003936_abnormal_reproductive_system0.91897051
59MP0001879_abnormal_lymphatic_vessel0.89858132
60MP0002080_prenatal_lethality0.89141222
61MP0000358_abnormal_cell_content/0.89128684
62MP0002085_abnormal_embryonic_tissue0.88586048
63MP0005647_abnormal_sex_gland0.88340260
64MP0001188_hyperpigmentation0.87279627
65MP0003123_paternal_imprinting0.85927659
66MP0001661_extended_life_span0.84873892
67MP0003567_abnormal_fetal_cardiomyocyte0.84483502
68MP0004019_abnormal_vitamin_homeostasis0.84452798
69MP0005187_abnormal_penis_morphology0.84380306
70MP0006036_abnormal_mitochondrial_physio0.82578170
71MP0003937_abnormal_limbs/digits/tail_de0.79197299
72MP0000313_abnormal_cell_death0.78952963
73MP0004197_abnormal_fetal_growth/weight/0.73680928
74MP0000647_abnormal_sebaceous_gland0.71763278
75MP0003984_embryonic_growth_retardation0.70934883
76MP0000462_abnormal_digestive_system0.70746925
77MP0002088_abnormal_embryonic_growth/wei0.69480784
78MP0008875_abnormal_xenobiotic_pharmacok0.69373679
79MP0003119_abnormal_digestive_system0.68308125
80MP0004145_abnormal_muscle_electrophysio0.67088596
81MP0002138_abnormal_hepatobiliary_system0.64611140
82MP0002086_abnormal_extraembryonic_tissu0.63421697
83MP0003252_abnormal_bile_duct0.63073064
84MP0003656_abnormal_erythrocyte_physiolo0.61141770
85MP0003943_abnormal_hepatobiliary_system0.56950534
86MP0000631_abnormal_neuroendocrine_gland0.56863232
87MP0002095_abnormal_skin_pigmentation0.56356525
88MP0009703_decreased_birth_body0.53463259
89MP0004215_abnormal_myocardial_fiber0.52145277
90MP0001177_atelectasis0.51545523
91MP0002163_abnormal_gland_morphology0.50586277
92MP0004782_abnormal_surfactant_physiolog0.49778530
93MP0008789_abnormal_olfactory_epithelium0.48584593
94MP0003880_abnormal_central_pattern0.47679527
95MP0002796_impaired_skin_barrier0.47465228
96MP0000015_abnormal_ear_pigmentation0.47283078
97MP0002269_muscular_atrophy0.47173252
98MP0000609_abnormal_liver_physiology0.46466546
99MP0003136_yellow_coat_color0.45395342
100MP0010329_abnormal_lipoprotein_level0.45274846

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.17646856
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.17646856
3Osteomalacia (HP:0002749)5.02763646
4Chromsome breakage (HP:0040012)4.72098286
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70621602
6Abnormality of the corticospinal tract (HP:0002492)4.17870959
7Volvulus (HP:0002580)3.90699469
8Gonadotropin excess (HP:0000837)3.73819581
9Abnormality of DNA repair (HP:0003254)3.48689967
10Azoospermia (HP:0000027)3.46610400
11Scotoma (HP:0000575)3.15582469
12Shoulder girdle muscle weakness (HP:0003547)2.93232939
13Ectopic kidney (HP:0000086)2.92485971
14Abnormality of the renal collecting system (HP:0004742)2.89749052
15Hyperglycinemia (HP:0002154)2.87602662
16Duodenal stenosis (HP:0100867)2.84013335
17Small intestinal stenosis (HP:0012848)2.84013335
18Horizontal nystagmus (HP:0000666)2.82056533
19Hyperglycinuria (HP:0003108)2.81164655
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.73278923
21Abnormal spermatogenesis (HP:0008669)2.69227001
22Abnormality of chromosome stability (HP:0003220)2.67868983
23Increased nuchal translucency (HP:0010880)2.62004581
24Reticulocytopenia (HP:0001896)2.58948411
25Abnormality of pyrimidine metabolism (HP:0004353)2.54262102
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53616258
27Abnormality of alanine metabolism (HP:0010916)2.53616258
28Hyperalaninemia (HP:0003348)2.53616258
29Duplicated collecting system (HP:0000081)2.52921630
30Impaired vibration sensation in the lower limbs (HP:0002166)2.52285478
31Delayed epiphyseal ossification (HP:0002663)2.50327435
32Birth length less than 3rd percentile (HP:0003561)2.49004634
33Abnormal lung lobation (HP:0002101)2.47052978
34Abnormality of glycine metabolism (HP:0010895)2.46947557
35Abnormality of serine family amino acid metabolism (HP:0010894)2.46947557
36Tubulointerstitial nephritis (HP:0001970)2.44762472
37Abnormality of the preputium (HP:0100587)2.41428111
38Abnormality of the costochondral junction (HP:0000919)2.40529255
39Spontaneous abortion (HP:0005268)2.37806792
40Truncus arteriosus (HP:0001660)2.37387664
41Abnormality of the duodenum (HP:0002246)2.34985731
42Meckel diverticulum (HP:0002245)2.30541177
43Abnormality of the labia minora (HP:0012880)2.28949376
44Rhabdomyosarcoma (HP:0002859)2.28723966
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.27721124
46Proximal tubulopathy (HP:0000114)2.23753969
47Rickets (HP:0002748)2.22810554
48Rimmed vacuoles (HP:0003805)2.22717450
49Premature ovarian failure (HP:0008209)2.20159781
50Short middle phalanx of the 5th finger (HP:0004220)2.18990608
51Microvesicular hepatic steatosis (HP:0001414)2.18381454
52Oligodactyly (hands) (HP:0001180)2.17967079
53Ependymoma (HP:0002888)2.15252615
54Short tibia (HP:0005736)2.14329464
55Supernumerary spleens (HP:0009799)2.13740385
56Abnormality of the ileum (HP:0001549)2.11943305
57Agnosia (HP:0010524)2.11074373
58Horseshoe kidney (HP:0000085)2.09368000
59Abnormality of cochlea (HP:0000375)2.07707298
60Upper limb muscle weakness (HP:0003484)2.07248014
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.02521714
62Upper motor neuron abnormality (HP:0002127)2.01288887
63Hypobetalipoproteinemia (HP:0003563)2.00767499
64Neoplasm of the oral cavity (HP:0100649)2.00242770
65Retinal dysplasia (HP:0007973)1.96615242
66Absent radius (HP:0003974)1.95749208
67Abnormality of serum amino acid levels (HP:0003112)1.93467280
68Capillary hemangiomas (HP:0005306)1.92563448
69Reduced antithrombin III activity (HP:0001976)1.91744043
70Cerebral edema (HP:0002181)1.91349161
71Amyotrophic lateral sclerosis (HP:0007354)1.90755638
72Acanthocytosis (HP:0001927)1.89708503
73Papillary thyroid carcinoma (HP:0002895)1.88533391
74Sloping forehead (HP:0000340)1.88520238
75Cholecystitis (HP:0001082)1.87874795
76Abnormal gallbladder physiology (HP:0012438)1.87874795
77Hypergonadotropic hypogonadism (HP:0000815)1.86589609
78Male infertility (HP:0003251)1.85995402
79Prolonged partial thromboplastin time (HP:0003645)1.84728160
80Urinary urgency (HP:0000012)1.84447252
81Aplasia involving forearm bones (HP:0009822)1.84108842
82Absent forearm bone (HP:0003953)1.84108842
83Microglossia (HP:0000171)1.83910082
84Abnormality of reticulocytes (HP:0004312)1.82082004
85Cortical dysplasia (HP:0002539)1.81695548
86Septate vagina (HP:0001153)1.81509270
87Facial hemangioma (HP:0000329)1.79342798
88Neoplasm of the small intestine (HP:0100833)1.78592820
89Abnormality of the lower motor neuron (HP:0002366)1.78525849
90Duplication of thumb phalanx (HP:0009942)1.78290102
91Poikilocytosis (HP:0004447)1.76380257
92Lipid accumulation in hepatocytes (HP:0006561)1.74180423
93Absent thumb (HP:0009777)1.74154983
94Generalized aminoaciduria (HP:0002909)1.73816804
95CNS hypomyelination (HP:0003429)1.73270585
96Impulsivity (HP:0100710)1.72236085
97Hypoplasia of the uterus (HP:0000013)1.72000125
98Glioma (HP:0009733)1.71613046
99Median cleft lip (HP:0000161)1.71514475
100Bowel incontinence (HP:0002607)1.71062792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.20391081
2PNCK4.60001595
3TTK3.83049232
4CDK193.79106764
5PLK43.06260048
6CDK122.82730014
7KSR22.74921064
8PBK2.67983850
9WEE12.36548891
10CDC72.34141149
11MAP3K22.26990931
12ZAK2.07329786
13NTRK32.04163724
14RAF11.88351706
15WNK41.82058990
16STK241.73647970
17PLK11.70088047
18KSR11.64694217
19BUB11.61546703
20BRSK21.57807879
21MATK1.52567710
22MUSK1.49581576
23STK391.45370252
24BRSK11.44767656
25STK31.37916433
26BRAF1.35724301
27STK161.32362870
28ATR1.27497311
29MAP3K41.24404686
30PDK21.22580792
31WNK11.20983599
32MET1.20711868
33EIF2AK31.18781724
34TYRO31.09080286
35CHEK11.08832269
36AURKA1.06933607
37CLK11.05656540
38ATM1.04921407
39CHEK21.03027293
40CDK81.01213408
41NEK60.99770562
42CDK70.99695675
43NEK90.96452528
44MAP3K80.93058043
45YES10.88812769
46STK38L0.86448626
47BMPR1B0.86028186
48EPHA40.80657838
49CCNB10.78683852
50PASK0.78496313
51NEK20.77371970
52SRPK10.67765887
53BRD40.67570616
54PLK20.65942125
55PIM10.64500119
56AURKB0.64094897
57CAMK1G0.63635462
58MAP3K90.63115849
59PLK30.62024783
60TSSK60.61596314
61CDK10.59141956
62BMX0.56114271
63CDK20.55624159
64RPS6KB10.55567405
65PRKCI0.55323291
66CDK40.53609842
67EIF2AK10.51641296
68NEK10.50976260
69PIK3CG0.49973820
70CSNK2A20.46948803
71MAP3K130.46604946
72MARK30.46511034
73ARAF0.44554875
74CSNK1G20.43005490
75SGK10.42141696
76CDK30.41793963
77BCR0.41084888
78SCYL20.40767313
79CSNK2A10.39941127
80MST40.38918969
81VRK10.38176443
82RPS6KB20.37470151
83FRK0.37350229
84PRKDC0.36188917
85CSNK1E0.34804454
86BMPR20.34173476
87TLK10.33466810
88NME10.32872963
89RET0.32822691
90BCKDK0.31846703
91DYRK30.31512528
92PRKG10.30152277
93MST1R0.29213058
94PINK10.28954942
95PRKACB0.27807182
96MAP2K10.26795419
97ERBB40.26478974
98STK40.25996412
99TAF10.25542887
100MAP3K70.22966150

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.04850548
2DNA replication_Homo sapiens_hsa030303.82827931
3Homologous recombination_Homo sapiens_hsa034403.10608328
4Fanconi anemia pathway_Homo sapiens_hsa034602.90027137
5Base excision repair_Homo sapiens_hsa034102.86290295
6Cell cycle_Homo sapiens_hsa041102.70382750
7Nucleotide excision repair_Homo sapiens_hsa034202.66124370
8Basal transcription factors_Homo sapiens_hsa030222.64689805
9Non-homologous end-joining_Homo sapiens_hsa034502.60741727
10RNA transport_Homo sapiens_hsa030132.55992692
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46597555
12Dorso-ventral axis formation_Homo sapiens_hsa043202.31533331
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12128351
14Propanoate metabolism_Homo sapiens_hsa006402.11202978
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98186568
16Folate biosynthesis_Homo sapiens_hsa007901.89844764
17Oocyte meiosis_Homo sapiens_hsa041141.77790995
18One carbon pool by folate_Homo sapiens_hsa006701.70258110
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.65996687
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65812210
21Steroid biosynthesis_Homo sapiens_hsa001001.65498819
22RNA degradation_Homo sapiens_hsa030181.61027638
23mRNA surveillance pathway_Homo sapiens_hsa030151.54703325
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51731277
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51622943
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.49052315
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48885715
28Ribosome_Homo sapiens_hsa030101.47744125
29Pyruvate metabolism_Homo sapiens_hsa006201.39739526
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38751917
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34950232
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33614886
33Sulfur relay system_Homo sapiens_hsa041221.32378128
34Retinol metabolism_Homo sapiens_hsa008301.28747750
35Regulation of autophagy_Homo sapiens_hsa041401.26568353
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24320606
37Arginine biosynthesis_Homo sapiens_hsa002201.23495906
38RNA polymerase_Homo sapiens_hsa030201.21077964
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.14338116
40Fatty acid degradation_Homo sapiens_hsa000711.07916393
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.03506436
42Fatty acid elongation_Homo sapiens_hsa000621.03440164
43Protein export_Homo sapiens_hsa030600.99940016
44beta-Alanine metabolism_Homo sapiens_hsa004100.99164056
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95676538
46Pyrimidine metabolism_Homo sapiens_hsa002400.93635983
47Fatty acid metabolism_Homo sapiens_hsa012120.93201506
48Butanoate metabolism_Homo sapiens_hsa006500.93139731
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.89268093
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87869172
51ABC transporters_Homo sapiens_hsa020100.85604519
52Spliceosome_Homo sapiens_hsa030400.84447893
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81407122
54Selenocompound metabolism_Homo sapiens_hsa004500.79818974
55Carbon metabolism_Homo sapiens_hsa012000.77703136
56p53 signaling pathway_Homo sapiens_hsa041150.74709326
57Peroxisome_Homo sapiens_hsa041460.74047551
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72591844
59Caffeine metabolism_Homo sapiens_hsa002320.71578631
60Phenylalanine metabolism_Homo sapiens_hsa003600.70720994
61Purine metabolism_Homo sapiens_hsa002300.69698152
62Olfactory transduction_Homo sapiens_hsa047400.69209371
63Arginine and proline metabolism_Homo sapiens_hsa003300.68061354
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67297522
65Tyrosine metabolism_Homo sapiens_hsa003500.65794230
66Chemical carcinogenesis_Homo sapiens_hsa052040.65656714
67Complement and coagulation cascades_Homo sapiens_hsa046100.61494972
68Huntingtons disease_Homo sapiens_hsa050160.59389172
69Linoleic acid metabolism_Homo sapiens_hsa005910.57349354
70Sulfur metabolism_Homo sapiens_hsa009200.55041440
71Metabolic pathways_Homo sapiens_hsa011000.54870031
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48660601
73TGF-beta signaling pathway_Homo sapiens_hsa043500.48584683
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48239453
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47812241
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46493263
77Lysine degradation_Homo sapiens_hsa003100.45985818
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45769069
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44940426
80mTOR signaling pathway_Homo sapiens_hsa041500.43990427
81N-Glycan biosynthesis_Homo sapiens_hsa005100.42285271
82Bile secretion_Homo sapiens_hsa049760.41758190
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41025855
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39004080
85Parkinsons disease_Homo sapiens_hsa050120.36788472
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35257417
87Nicotine addiction_Homo sapiens_hsa050330.32760659
88Glutathione metabolism_Homo sapiens_hsa004800.31692512
89Circadian rhythm_Homo sapiens_hsa047100.30317655
90Proteasome_Homo sapiens_hsa030500.28611157
91Fat digestion and absorption_Homo sapiens_hsa049750.25149607
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23967293
93Tryptophan metabolism_Homo sapiens_hsa003800.23661188
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21613718
95ErbB signaling pathway_Homo sapiens_hsa040120.21546532
96Oxidative phosphorylation_Homo sapiens_hsa001900.21482660
97Vitamin B6 metabolism_Homo sapiens_hsa007500.20056460
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.19788204
99Biosynthesis of amino acids_Homo sapiens_hsa012300.17537406
100Arachidonic acid metabolism_Homo sapiens_hsa005900.16363767

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