DCAF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10836176
2synaptic vesicle maturation (GO:0016188)4.09545413
3histone H3-K4 trimethylation (GO:0080182)4.05185556
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98938762
5locomotory exploration behavior (GO:0035641)3.90223054
6layer formation in cerebral cortex (GO:0021819)3.59356558
7synaptic vesicle docking involved in exocytosis (GO:0016081)3.57528430
8glutamate secretion (GO:0014047)3.52540062
9synaptic vesicle exocytosis (GO:0016079)3.42889822
10regulation of ARF protein signal transduction (GO:0032012)3.41646128
11histone H3-K36 demethylation (GO:0070544)3.39995352
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39185020
13activation of protein kinase A activity (GO:0034199)3.38956763
14sarcoplasmic reticulum calcium ion transport (GO:0070296)3.36105498
15regulation of synaptic vesicle exocytosis (GO:2000300)3.31385908
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23203196
17regulation of glutamate receptor signaling pathway (GO:1900449)3.13362596
18regulation of glycogen (starch) synthase activity (GO:2000465)3.12857259
19vocalization behavior (GO:0071625)3.11785077
20regulation of synaptic vesicle transport (GO:1902803)3.05945435
21histone H3-K9 demethylation (GO:0033169)3.04678460
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01979162
23mannose metabolic process (GO:0006013)3.01000794
24regulation of synapse structural plasticity (GO:0051823)2.98400275
25neurotransmitter secretion (GO:0007269)2.95227616
26histone H3-K9 modification (GO:0061647)2.95205698
27sodium ion export (GO:0071436)2.94696253
28protein targeting to Golgi (GO:0000042)2.91255789
29establishment of protein localization to Golgi (GO:0072600)2.89834995
30regulation of clathrin-mediated endocytosis (GO:2000369)2.83021146
31exploration behavior (GO:0035640)2.82527777
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81567689
33protein localization to synapse (GO:0035418)2.80928347
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.79732383
35cerebellar Purkinje cell differentiation (GO:0021702)2.79480234
36cell communication by electrical coupling (GO:0010644)2.77951872
37dendritic spine morphogenesis (GO:0060997)2.77155508
38response to inactivity (GO:0014854)2.77133113
39dendrite morphogenesis (GO:0048813)2.76705710
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75289291
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.72192683
42cellular potassium ion homeostasis (GO:0030007)2.71704688
43membrane depolarization during action potential (GO:0086010)2.69539091
44peptidyl-lysine trimethylation (GO:0018023)2.67992446
45actin-myosin filament sliding (GO:0033275)2.67174058
46muscle filament sliding (GO:0030049)2.67174058
47retrograde transport, vesicle recycling within Golgi (GO:0000301)2.66236858
48regulation of neuronal synaptic plasticity (GO:0048168)2.66200049
49histone lysine demethylation (GO:0070076)2.64728364
50plasma membrane repair (GO:0001778)2.64672424
51negative regulation of potassium ion transmembrane transport (GO:1901380)2.63145854
52establishment of nucleus localization (GO:0040023)2.61264811
53cytoskeletal anchoring at plasma membrane (GO:0007016)2.61152930
54cell-cell junction maintenance (GO:0045217)2.57954787
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.56931259
56myofibril assembly (GO:0030239)2.55410935
57phosphatidylinositol dephosphorylation (GO:0046856)2.54947602
58histone H3-K9 methylation (GO:0051567)2.54416538
59nucleobase catabolic process (GO:0046113)2.53412330
60histone demethylation (GO:0016577)2.52961431
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52508464
62histone H3-K4 methylation (GO:0051568)2.51869183
63vesicle transport along microtubule (GO:0047496)2.51568560
64phospholipid dephosphorylation (GO:0046839)2.51446001
65cell communication involved in cardiac conduction (GO:0086065)2.50939422
66gamma-aminobutyric acid transport (GO:0015812)2.50084799
67regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48823236
68calcium ion-dependent exocytosis (GO:0017156)2.48107064
69negative regulation of erythrocyte differentiation (GO:0045647)2.46598961
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.45659944
71camera-type eye morphogenesis (GO:0048593)2.45654982
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.43675120
73axonal fasciculation (GO:0007413)2.42945866
74cerebral cortex neuron differentiation (GO:0021895)2.42641441
75actin-mediated cell contraction (GO:0070252)2.42549323
76proline transport (GO:0015824)2.42243283
77synaptic vesicle endocytosis (GO:0048488)2.41728169
78negative regulation of inclusion body assembly (GO:0090084)2.40378963
79neuromuscular process controlling balance (GO:0050885)2.39696256
80cell migration in hindbrain (GO:0021535)2.39503259
81prepulse inhibition (GO:0060134)2.38636005
82response to muramyl dipeptide (GO:0032495)2.37682567
83neuron recognition (GO:0008038)2.37099271
84neuron cell-cell adhesion (GO:0007158)2.36629148
85potassium ion import (GO:0010107)2.36301981
86positive regulation of myoblast differentiation (GO:0045663)2.35905506
87actin filament-based movement (GO:0030048)2.35747846
88negative regulation of cAMP-mediated signaling (GO:0043951)2.35579173
89innervation (GO:0060384)2.35273442
90cardiac myofibril assembly (GO:0055003)2.34648057
91neurotransmitter-gated ion channel clustering (GO:0072578)2.34323880
92regulation of ARF GTPase activity (GO:0032312)2.33897107
93nerve growth factor signaling pathway (GO:0038180)2.32409494
94axon extension (GO:0048675)2.32140672
95nucleus localization (GO:0051647)2.30873117
96histone H4 deacetylation (GO:0070933)2.30188709
97cell junction maintenance (GO:0034331)2.30072187
98cerebellar Purkinje cell layer development (GO:0021680)2.30026366
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.28643995
100regulation of fatty acid beta-oxidation (GO:0031998)2.28073312
101peptidyl-lysine methylation (GO:0018022)2.27307338
102peptidyl-threonine phosphorylation (GO:0018107)2.25747072
103regulation of dendritic spine morphogenesis (GO:0061001)2.24978126
104suckling behavior (GO:0001967)2.24739117
105organelle transport along microtubule (GO:0072384)2.24388949
106dicarboxylic acid biosynthetic process (GO:0043650)2.24384392
107regulation of acrosome reaction (GO:0060046)2.23866676
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.23433209
109cytoplasmic mRNA processing body assembly (GO:0033962)2.23029918
110cardiac muscle hypertrophy (GO:0003300)2.22804493
111negative regulation of cell killing (GO:0031342)2.22521521
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22521521
113protein dealkylation (GO:0008214)2.22190700
114protein demethylation (GO:0006482)2.22190700
115regulation of NFAT protein import into nucleus (GO:0051532)2.20997342
116macroautophagy (GO:0016236)2.20408761
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.20362813
118long-term memory (GO:0007616)2.19044329
119neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.18010126
120negative regulation of cell size (GO:0045792)2.16988616
121central nervous system projection neuron axonogenesis (GO:0021952)2.16606860
122peptidyl-threonine modification (GO:0018210)2.15954667
123protein localization to endosome (GO:0036010)2.15915474
124activated T cell proliferation (GO:0050798)2.15774280
125myoblast fusion (GO:0007520)2.14802379
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.14123466
127epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.14095187
128pyrimidine nucleobase catabolic process (GO:0006208)2.14000374
129clathrin coat assembly (GO:0048268)2.13687859
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.13207643
131neurotransmitter transport (GO:0006836)2.13181760
132striated muscle hypertrophy (GO:0014897)2.12369179
133regulation of synaptic plasticity (GO:0048167)2.12277964
134negative regulation of sodium ion transport (GO:0010766)2.10895236
135cellular sodium ion homeostasis (GO:0006883)2.10743238
136glutamate receptor signaling pathway (GO:0007215)2.10743066
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.10694427
138positive regulation of synapse maturation (GO:0090129)2.10668988
139regulation of membrane repolarization (GO:0060306)2.10587250
140cellular response to epinephrine stimulus (GO:0071872)2.10361700
141synaptic transmission, glutamatergic (GO:0035249)2.10351351
142regulation of sodium ion transmembrane transporter activity (GO:2000649)2.10158358
143mating behavior (GO:0007617)2.09857487
144regulation of gamma-delta T cell differentiation (GO:0045586)2.09671630
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.09547908
146histone lysine methylation (GO:0034968)2.09053975
147regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.08803499
148interkinetic nuclear migration (GO:0022027)2.08760626
149stress granule assembly (GO:0034063)2.08608318
150sarcomere organization (GO:0045214)2.07832383
151cardiac muscle hypertrophy in response to stress (GO:0014898)2.06886039
152muscle hypertrophy in response to stress (GO:0003299)2.06886039
153cardiac muscle adaptation (GO:0014887)2.06886039
154regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.06182019
155syncytium formation by plasma membrane fusion (GO:0000768)2.04843513
156maintenance of protein location in nucleus (GO:0051457)2.04362368
157skeletal muscle contraction (GO:0003009)2.03468339
158positive regulation of gastrulation (GO:2000543)2.03119398
159developmental cell growth (GO:0048588)2.02054438
160regulation of actin filament-based movement (GO:1903115)2.01633156
161cellular response to catecholamine stimulus (GO:0071870)2.01508801
162cellular response to monoamine stimulus (GO:0071868)2.01508801
163regulation of female gonad development (GO:2000194)2.01040824
164neuron projection extension (GO:1990138)1.98360194
165cellular response to interleukin-15 (GO:0071350)1.97933465
166regulation of gamma-delta T cell activation (GO:0046643)1.97532585
167negative regulation of T cell mediated immunity (GO:0002710)1.96747709
168brain morphogenesis (GO:0048854)1.94940732
169tolerance induction (GO:0002507)1.94455830
170regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.91752596
171positive regulation of gene expression, epigenetic (GO:0045815)1.91464450
172centrosome localization (GO:0051642)1.91316147
173carnitine shuttle (GO:0006853)1.91011348
174atrioventricular valve morphogenesis (GO:0003181)1.90988016
175negative regulation of Ras protein signal transduction (GO:0046580)1.90937175
176interferon-gamma production (GO:0032609)1.90862540
177striated muscle adaptation (GO:0014888)1.90365378
178heart valve formation (GO:0003188)1.90355888
179fibroblast migration (GO:0010761)1.90287193
180response to interleukin-15 (GO:0070672)1.90233240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05635681
2DROSHA_22980978_ChIP-Seq_HELA_Human2.18537892
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.00466875
4* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83081788
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82634165
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80766516
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79097904
8MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78913152
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74280951
10GBX2_23144817_ChIP-Seq_PC3_Human1.73826876
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72545230
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72545230
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71694564
14REST_21632747_ChIP-Seq_MESCs_Mouse1.71053284
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66407450
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66024324
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54401167
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53198507
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52026398
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.50270909
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48740014
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.46056526
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45689063
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44365192
25KDM2B_26808549_Chip-Seq_K562_Human1.43824522
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43411379
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43335491
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42357133
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42215928
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41468797
31RUNX_20019798_ChIP-Seq_JUKART_Human1.40850174
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39817733
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.37568733
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34558066
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34360976
36ZNF274_21170338_ChIP-Seq_K562_Hela1.33962526
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32829378
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.32527183
39WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31575976
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28874514
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28246317
42* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28150226
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28060577
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24310088
45* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23537757
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23354818
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23304209
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23270541
49SMAD4_21799915_ChIP-Seq_A2780_Human1.21860286
50AHR_22903824_ChIP-Seq_MCF-7_Human1.21419578
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21035902
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.20309297
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.20159398
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.19056605
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.18737874
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18263266
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.18225930
58* KDM2B_26808549_Chip-Seq_DND41_Human1.16966158
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15807482
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14788216
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14584218
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14282042
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12946640
64AR_19668381_ChIP-Seq_PC3_Human1.12928148
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.12035531
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11622267
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.09827893
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.08725550
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.08116848
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07698435
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05854130
72* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05123887
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04652978
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.04630932
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04600745
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04210239
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.03959710
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03853848
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.03519284
80* STAT3_23295773_ChIP-Seq_U87_Human1.02365461
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02345967
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02108044
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01581190
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01217987
85* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00656246
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00491579
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99821105
88AR_21572438_ChIP-Seq_LNCaP_Human0.99504338
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99087490
90* TCF7_22412390_ChIP-Seq_EML_Mouse0.97264719
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97082134
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96935439
93* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96686565
94VDR_24787735_ChIP-Seq_THP-1_Human0.96552022
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96465570
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94922484
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94279138
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94093901
99* CTCF_27219007_Chip-Seq_Bcells_Human0.93671190
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.93525238
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92697739
102TP53_20018659_ChIP-ChIP_R1E_Mouse0.91929812
103AR_25329375_ChIP-Seq_VCAP_Human0.91045892
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.90416285
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89290026
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89265528
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.89011762
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.88639027
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88530156
110TAF15_26573619_Chip-Seq_HEK293_Human0.88527301
111* TCF4_23295773_ChIP-Seq_U87_Human0.88261871
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88001931
113TP53_16413492_ChIP-PET_HCT116_Human0.86127044
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85397204
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85397204
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.85384576
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.85384576
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85379182
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.84119254
120* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84091896
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.82467721
122GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82321143
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.81668080
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81645744
125SPI1_23127762_ChIP-Seq_K562_Human0.80087219
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.79669171
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.79567141
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.78654448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.28958206
2MP0003635_abnormal_synaptic_transmissio3.16901000
3MP0004270_analgesia3.14768323
4MP0005409_darkened_coat_color3.01427608
5MP0002837_dystrophic_cardiac_calcinosis2.70005422
6MP0000569_abnormal_digit_pigmentation2.51805902
7MP0009780_abnormal_chondrocyte_physiolo2.47626459
8MP0002063_abnormal_learning/memory/cond2.45351813
9MP0003329_amyloid_beta_deposits2.24270966
10MP0004130_abnormal_muscle_cell2.22970913
11MP0008961_abnormal_basal_metabolism2.21984993
12MP0002909_abnormal_adrenal_gland2.21247047
13MP0003828_pulmonary_edema2.14168678
14MP0002822_catalepsy2.13555980
15MP0003880_abnormal_central_pattern2.13459829
16MP0009745_abnormal_behavioral_response2.07653653
17MP0000751_myopathy2.03078094
18MP0005423_abnormal_somatic_nervous2.02986826
19MP0002127_abnormal_cardiovascular_syste1.95658284
20MP0006138_congestive_heart_failure1.91772400
21MP0002064_seizures1.85376489
22MP0002572_abnormal_emotion/affect_behav1.80935098
23MP0009046_muscle_twitch1.75720186
24MP0003787_abnormal_imprinting1.73711671
25MP0005365_abnormal_bile_salt1.70906584
26MP0002139_abnormal_hepatobiliary_system1.69523275
27MP0004510_myositis1.68289401
28MP0005410_abnormal_fertilization1.67923232
29MP0004858_abnormal_nervous_system1.67794975
30MP0010234_abnormal_vibrissa_follicle1.64432131
31MP0001968_abnormal_touch/_nociception1.62943529
32MP0001984_abnormal_olfaction1.60761320
33MP0000749_muscle_degeneration1.58184518
34MP0002734_abnormal_mechanical_nocicepti1.57438787
35MP0008569_lethality_at_weaning1.56307171
36MP0001486_abnormal_startle_reflex1.55289153
37MP0003121_genomic_imprinting1.55036177
38MP0008789_abnormal_olfactory_epithelium1.54603756
39MP0005394_taste/olfaction_phenotype1.54404739
40MP0005499_abnormal_olfactory_system1.54404739
41MP0002108_abnormal_muscle_morphology1.53616452
42MP0000013_abnormal_adipose_tissue1.53554882
43MP0003763_abnormal_thymus_physiology1.53169718
44MP0005369_muscle_phenotype1.51927063
45MP0010368_abnormal_lymphatic_system1.49598127
46MP0004811_abnormal_neuron_physiology1.47686934
47MP0005645_abnormal_hypothalamus_physiol1.47072279
48MP0004142_abnormal_muscle_tone1.46566579
49MP0000003_abnormal_adipose_tissue1.40391047
50MP0003252_abnormal_bile_duct1.37550315
51MP0000733_abnormal_muscle_development1.37414135
52MP0003646_muscle_fatigue1.36116457
53MP0002009_preneoplasia1.35681882
54MP0004885_abnormal_endolymph1.33129083
55MP0003436_decreased_susceptibility_to1.32734962
56MP0003705_abnormal_hypodermis_morpholog1.32163153
57MP0004036_abnormal_muscle_relaxation1.31621783
58MP0002272_abnormal_nervous_system1.30795615
59MP0005187_abnormal_penis_morphology1.30773772
60MP0004145_abnormal_muscle_electrophysio1.29776342
61MP0002332_abnormal_exercise_endurance1.29695898
62MP0001501_abnormal_sleep_pattern1.28951201
63MP0004233_abnormal_muscle_weight1.28761545
64MP0002184_abnormal_innervation1.28450129
65MP0005623_abnormal_meninges_morphology1.28419026
66MP0004924_abnormal_behavior1.28107467
67MP0005386_behavior/neurological_phenoty1.28107467
68MP0000604_amyloidosis1.27864145
69MP0001502_abnormal_circadian_rhythm1.26123171
70MP0005360_urolithiasis1.25499420
71MP0001440_abnormal_grooming_behavior1.23871791
72MP0002971_abnormal_brown_adipose1.21107111
73MP0005085_abnormal_gallbladder_physiolo1.21029489
74MP0003300_gastrointestinal_ulcer1.20731069
75MP0000778_abnormal_nervous_system1.20489798
76MP0008875_abnormal_xenobiotic_pharmacok1.18857872
77MP0002733_abnormal_thermal_nociception1.18782808
78MP0010329_abnormal_lipoprotein_level1.17648496
79MP0005375_adipose_tissue_phenotype1.17518403
80MP0004087_abnormal_muscle_fiber1.16519889
81MP0003879_abnormal_hair_cell1.15770440
82MP0003633_abnormal_nervous_system1.13618981
83MP0004084_abnormal_cardiac_muscle1.13503434
84MP0002067_abnormal_sensory_capabilities1.12580842
85MP0009115_abnormal_fat_cell1.11639681
86MP0003948_abnormal_gas_homeostasis1.10104044
87MP0000767_abnormal_smooth_muscle1.09843152
88MP0004085_abnormal_heartbeat1.09089128
89MP0002557_abnormal_social/conspecific_i1.08647162
90MP0004215_abnormal_myocardial_fiber1.07642826
91MP0004185_abnormal_adipocyte_glucose1.07476921
92MP0009384_cardiac_valve_regurgitation1.06650021
93MP0000955_abnormal_spinal_cord1.06338767
94MP0008877_abnormal_DNA_methylation1.04281732
95MP0001879_abnormal_lymphatic_vessel1.04141409
96MP0005666_abnormal_adipose_tissue1.04073765
97MP0001348_abnormal_lacrimal_gland1.03961142
98MP0003122_maternal_imprinting1.03067171
99MP0006276_abnormal_autonomic_nervous1.02193971
100MP0001851_eye_inflammation1.00114129
101MP0001970_abnormal_pain_threshold0.99836789
102MP0008874_decreased_physiological_sensi0.98544873
103MP0002066_abnormal_motor_capabilities/c0.96777607
104MP0002933_joint_inflammation0.94966485
105MP0000747_muscle_weakness0.94616277
106MP0005620_abnormal_muscle_contractility0.93897117
107MP0003890_abnormal_embryonic-extraembry0.93403269
108MP0003045_fibrosis0.92843667
109MP0002998_abnormal_bone_remodeling0.92741307
110MP0003868_abnormal_feces_composition0.91878551
111MP0002972_abnormal_cardiac_muscle0.91370867
112MP0003091_abnormal_cell_migration0.90595606
113MP0005535_abnormal_body_temperature0.90370825
114MP0005385_cardiovascular_system_phenoty0.90227493
115MP0001544_abnormal_cardiovascular_syste0.90227493
116MP0002882_abnormal_neuron_morphology0.88820163
117MP0002152_abnormal_brain_morphology0.88515999
118MP0002736_abnormal_nociception_after0.86468080
119MP0002078_abnormal_glucose_homeostasis0.84997918
120MP0002234_abnormal_pharynx_morphology0.84890881
121MP0005670_abnormal_white_adipose0.83444966
122MP0002735_abnormal_chemical_nociception0.83284629
123MP0001299_abnormal_eye_distance/0.82178310
124MP0003631_nervous_system_phenotype0.82056496
125MP0004134_abnormal_chest_morphology0.81800137
126MP0005503_abnormal_tendon_morphology0.81314033
127MP0002106_abnormal_muscle_physiology0.81087525
128MP0004484_altered_response_of0.80979947
129MP0002269_muscular_atrophy0.80450809
130MP0003183_abnormal_peptide_metabolism0.78968103
131MP0010630_abnormal_cardiac_muscle0.77421458
132MP0002069_abnormal_eating/drinking_beha0.76974798
133MP0000759_abnormal_skeletal_muscle0.76170222
134MP0002118_abnormal_lipid_homeostasis0.75621822
135MP0005330_cardiomyopathy0.75140038
136MP0003724_increased_susceptibility_to0.75068609
137MP0005448_abnormal_energy_balance0.75026065
138MP0005076_abnormal_cell_differentiation0.74189382
139MP0002138_abnormal_hepatobiliary_system0.74154259
140MP0002166_altered_tumor_susceptibility0.73474389
141MP0004133_heterotaxia0.72936694
142MP0000750_abnormal_muscle_regeneration0.72219052
143MP0003303_peritoneal_inflammation0.70804607
144MP0002638_abnormal_pupillary_reflex0.68726011
145MP0005310_abnormal_salivary_gland0.66605834
146MP0001800_abnormal_humoral_immune0.66577441
147MP0001790_abnormal_immune_system0.64545214
148MP0005387_immune_system_phenotype0.64545214
149MP0003172_abnormal_lysosome_physiology0.64326475
150MP0005388_respiratory_system_phenotype0.62108425
151MP0002133_abnormal_respiratory_system0.62108425
152MP0000266_abnormal_heart_morphology0.61686315

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.41764507
2Muscle fiber inclusion bodies (HP:0100299)3.40736846
3Obstructive sleep apnea (HP:0002870)3.34124524
4Focal motor seizures (HP:0011153)3.32462453
5Type 1 muscle fiber predominance (HP:0003803)3.30823647
6Focal seizures (HP:0007359)3.21171987
7Nemaline bodies (HP:0003798)3.17346912
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.16138778
9Abnormality of the lower motor neuron (HP:0002366)3.11712300
10Dysmetric saccades (HP:0000641)2.99877080
11Genetic anticipation (HP:0003743)2.89507644
12Visual hallucinations (HP:0002367)2.87560252
13Bundle branch block (HP:0011710)2.83053045
14Macroorchidism (HP:0000053)2.76088076
15Atonic seizures (HP:0010819)2.68911668
16Muscle fiber splitting (HP:0003555)2.68625219
17Ulnar deviation of the wrist (HP:0003049)2.67902325
18Deep venous thrombosis (HP:0002625)2.67008111
19Action tremor (HP:0002345)2.66436943
20Exercise-induced myalgia (HP:0003738)2.66257348
21Supranuclear gaze palsy (HP:0000605)2.65100629
22Progressive cerebellar ataxia (HP:0002073)2.58528703
23Impaired social interactions (HP:0000735)2.53562273
24Abnormal social behavior (HP:0012433)2.53562273
25Hyperkalemia (HP:0002153)2.51324625
26Hypoplastic ischia (HP:0003175)2.51204265
27Urinary bladder sphincter dysfunction (HP:0002839)2.48007320
28Subaortic stenosis (HP:0001682)2.46462208
29Abnormality of the left ventricular outflow tract (HP:0011103)2.46462208
30Urinary urgency (HP:0000012)2.43988660
31Hyporeflexia of lower limbs (HP:0002600)2.40680948
32Termporal pattern (HP:0011008)2.39397617
33Insidious onset (HP:0003587)2.39397617
34Truncal obesity (HP:0001956)2.39118887
35Cerebral inclusion bodies (HP:0100314)2.38325563
36Hyperacusis (HP:0010780)2.37261350
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.35515523
38Impaired vibration sensation in the lower limbs (HP:0002166)2.34253052
39Abnormality of the calf musculature (HP:0001430)2.34003229
40Sudden death (HP:0001699)2.33048528
41Poor eye contact (HP:0000817)2.32402667
42Round ear (HP:0100830)2.30131156
43Depression (HP:0000716)2.29486335
44Drooling (HP:0002307)2.28586040
45Excessive salivation (HP:0003781)2.28586040
46Abnormality of the ischium (HP:0003174)2.26080488
47Increased connective tissue (HP:0009025)2.25415047
48Postural instability (HP:0002172)2.24514009
49Ventricular fibrillation (HP:0001663)2.24368469
50Absence seizures (HP:0002121)2.22994277
51Abnormality of the fingertips (HP:0001211)2.21015127
52Abnormality of the aortic arch (HP:0012303)2.16403239
53Frequent falls (HP:0002359)2.16195245
54Insomnia (HP:0100785)2.16040342
55Ventricular tachycardia (HP:0004756)2.13799706
56Generalized tonic-clonic seizures (HP:0002069)2.13246001
57Distal arthrogryposis (HP:0005684)2.13116993
58Hemiplegia (HP:0002301)2.12799273
59EMG: myopathic abnormalities (HP:0003458)2.12754296
60Oligomenorrhea (HP:0000876)2.11549973
61Renovascular hypertension (HP:0100817)2.11374075
62Epileptic encephalopathy (HP:0200134)2.08882579
63Torticollis (HP:0000473)2.07039089
64Agitation (HP:0000713)2.06922174
65Difficulty running (HP:0009046)2.05582786
66Male infertility (HP:0003251)2.04509296
67Long toe (HP:0010511)2.04157178
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03167058
69Testicular neoplasm (HP:0010788)2.02919417
70Peritonitis (HP:0002586)2.01583664
71Neurofibrillary tangles (HP:0002185)2.01372901
72Lower limb amyotrophy (HP:0007210)2.00582119
73Vertebral arch anomaly (HP:0008438)1.99491394
74Ankle clonus (HP:0011448)1.98632300
75Elfin facies (HP:0004428)1.97200357
76Cerebral aneurysm (HP:0004944)1.96981197
77Neonatal hypoglycemia (HP:0001998)1.95021129
78Striae distensae (HP:0001065)1.91564025
79Anterior segment dysgenesis (HP:0007700)1.91530549
80Dysmetria (HP:0001310)1.90044507
81Truncal ataxia (HP:0002078)1.89153810
82Febrile seizures (HP:0002373)1.89093114
83Hip contracture (HP:0003273)1.89007581
84Enlarged penis (HP:0000040)1.88351341
85Germ cell neoplasia (HP:0100728)1.87949259
86Syncope (HP:0001279)1.87676507
87Impaired smooth pursuit (HP:0007772)1.87440108
88Dysdiadochokinesis (HP:0002075)1.85991946
89Amyotrophic lateral sclerosis (HP:0007354)1.83687556
90Overgrowth (HP:0001548)1.82588415
91Buphthalmos (HP:0000557)1.82265129
92Distal lower limb muscle weakness (HP:0009053)1.81195160
93Fatigue (HP:0012378)1.81057970
94Increased variability in muscle fiber diameter (HP:0003557)1.80785142
95Lip pit (HP:0100267)1.80389518
96Spastic gait (HP:0002064)1.80109329
97Broad metatarsal (HP:0001783)1.79613656
98Supernumerary ribs (HP:0005815)1.79383541
99Mildly elevated creatine phosphokinase (HP:0008180)1.79352085
100Atrioventricular block (HP:0001678)1.79250249
101Papilledema (HP:0001085)1.78965929
102Abnormality of the Achilles tendon (HP:0005109)1.78915711
103Neoplasm of the heart (HP:0100544)1.78784826
104Papillary thyroid carcinoma (HP:0002895)1.78715714
105Hyperlipoproteinemia (HP:0010980)1.78478867
106Aneurysm (HP:0002617)1.77980030
107Calf muscle hypertrophy (HP:0008981)1.77935232
108Pointed chin (HP:0000307)1.77904998
109Hypercortisolism (HP:0001578)1.77690368
110Heart block (HP:0012722)1.77634756
111Bulbar palsy (HP:0001283)1.77398700
112Rapidly progressive (HP:0003678)1.77316051
113Dialeptic seizures (HP:0011146)1.77008743
114Asymmetric septal hypertrophy (HP:0001670)1.76989333
115Myopathic facies (HP:0002058)1.76214583
116Heterotopia (HP:0002282)1.76193496
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76073816
118Abnormal eating behavior (HP:0100738)1.74625938
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73510862
120Infertility (HP:0000789)1.73042281
121Amblyopia (HP:0000646)1.71286735
122Hypoventilation (HP:0002791)1.70965729
123Achilles tendon contracture (HP:0001771)1.70664359
124Prolonged QT interval (HP:0001657)1.70526027
125Focal dystonia (HP:0004373)1.70106968
126Abnormality of ocular smooth pursuit (HP:0000617)1.69437226
127Intention tremor (HP:0002080)1.69344343
128Atelectasis (HP:0100750)1.67723433
129EEG with generalized epileptiform discharges (HP:0011198)1.66406957
130Epileptiform EEG discharges (HP:0011182)1.66110220
131Hepatoblastoma (HP:0002884)1.65466821
132Abnormality of skeletal muscle fiber size (HP:0012084)1.64940710
133Absent/shortened dynein arms (HP:0200106)1.64867717
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.64867717
135EMG: neuropathic changes (HP:0003445)1.63889786
136Eczematoid dermatitis (HP:0000976)1.63700495
137Hypsarrhythmia (HP:0002521)1.63169715
138Anxiety (HP:0000739)1.62911479
139Muscle hypertrophy of the lower extremities (HP:0008968)1.62892351
140Primary atrial arrhythmia (HP:0001692)1.62881772
141Craniofacial dystonia (HP:0012179)1.62306242
142Exercise-induced muscle cramps (HP:0003710)1.62068923
143Impaired vibratory sensation (HP:0002495)1.61850293
144Spontaneous hematomas (HP:0007420)1.60872873
145Mitral valve prolapse (HP:0001634)1.60707170
146Thin bony cortex (HP:0002753)1.60385266
147Tubulointerstitial nephritis (HP:0001970)1.60251715
148Obsessive-compulsive behavior (HP:0000722)1.60018826
149Scanning speech (HP:0002168)1.59641219
150Abnormal atrioventricular conduction (HP:0005150)1.59252043
151Fetal akinesia sequence (HP:0001989)1.57365549
152Laryngomalacia (HP:0001601)1.57229144
153Proximal amyotrophy (HP:0007126)1.57036493
154Supernumerary bones of the axial skeleton (HP:0009144)1.56768672
155Abnormality of the right ventricle (HP:0001707)1.56285650
156Deep palmar crease (HP:0006191)1.56116133
157Limited hip movement (HP:0008800)1.55580893
158Flat acetabular roof (HP:0003180)1.55211864
159Right ventricular cardiomyopathy (HP:0011663)1.54535173
160Narrow palate (HP:0000189)1.53136846
161Tented upper lip vermilion (HP:0010804)1.53099960
162Long eyelashes (HP:0000527)1.52824028
163Thick eyebrow (HP:0000574)1.51506336
164Skin pits (HP:0100276)1.50613510
165Abnormality of the radial head (HP:0003995)1.49313452
166Abnormality of calcium-phosphate metabolism (HP:0100530)1.49302482
167Abnormality of the pubic bones (HP:0003172)1.48155192
168Neck muscle weakness (HP:0000467)1.48112115
169Prolonged bleeding time (HP:0003010)1.45793959
170Oligodontia (HP:0000677)1.44788058
171Hyperventilation (HP:0002883)1.44604099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.01430197
2PRKD32.84700436
3TRIB32.68093202
4MAP3K42.37145076
5NTRK32.37006226
6KSR22.29326310
7OBSCN2.23795921
8EPHA32.16382727
9MARK12.12420512
10PAK62.04978011
11DAPK22.02540119
12EPHB11.87178450
13MAP2K41.85558701
14LMTK21.84609817
15ERN11.82533272
16PKN21.82424046
17STK381.78007113
18CAMK1G1.75625827
19EPHA41.74508467
20RIPK11.73506576
21CDK121.69348150
22KSR11.65306249
23LATS21.65074069
24CAMKK11.58859174
25MINK11.58413802
26SIK21.54219519
27NTRK21.49812555
28PAK31.43743404
29ICK1.43327462
30TNK21.41472935
31TAOK11.40229434
32PRKCH1.40028536
33TYRO31.39407095
34PRPF4B1.38738343
35DMPK1.38221310
36BRD41.35783735
37NTRK11.35633379
38RET1.34326541
39PDK31.26447435
40PDK41.26447435
41MAPK151.25918782
42SGK31.25535966
43EEF2K1.25516688
44MAPK121.21177044
45MAP2K21.20404699
46PHKG11.20364998
47PHKG21.20364998
48TTN1.18016108
49CASK1.16150968
50LATS11.14760128
51SIK31.12100185
52MAP2K31.08339084
53PDGFRA1.07824390
54TYK21.06692541
55IKBKE1.06650016
56MARK21.05510553
57CAMK1D1.04630559
58MAPK71.03706902
59SGK21.02800330
60MAP3K71.02060380
61MAP2K70.99734352
62PDK10.98717141
63MAP4K10.98678118
64TXK0.97432916
65CDK50.97132578
66TNIK0.97044619
67NLK0.95207139
68STK110.94382863
69MAP3K100.90043794
70SIK10.88801505
71MAP3K20.88125559
72SGK2230.85962811
73SGK4940.85962811
74CSK0.80917904
75PDPK10.80911185
76MAP3K140.80599067
77EPHB20.80064731
78MAP3K130.79670640
79PTK2B0.76945764
80PTK60.76390564
81RIPK40.75939172
82DYRK1B0.75339745
83JAK10.73861299
84ZAP700.72387720
85PNCK0.70955523
86BTK0.70798653
87AKT30.70028026
88CSNK1G20.69751626
89PIK3CA0.69532108
90MAP3K10.68513479
91MAP3K60.67209333
92TAOK30.67137160
93FGFR20.66065192
94RAF10.64405541
95ALK0.64400296
96RPS6KL10.64188577
97RPS6KC10.64188577
98FGFR40.64068666
99TBK10.63989484
100PTK20.63519530
101WNK10.62772798
102MAPK110.62203900
103HCK0.61550268
104PRKD10.61181194
105PRKAA20.61056419
106RPS6KA20.61041673
107FGFR30.59667260
108FRK0.59489088
109SGK10.59356876
110PDGFRB0.59281911
111CDC42BPA0.58997887
112TRPM70.58590105
113MAP2K10.57431818
114CAMK10.56404756
115PRKAA10.55749443
116DAPK10.55599636
117FES0.55446031
118RPS6KA60.53636205
119NEK90.53064253
120MTOR0.52545541
121LCK0.51468802
122CAMK40.51064513
123CAMK2A0.49872891
124PRKD20.47776376
125RPS6KA30.47729641
126FER0.47567469
127PRKCG0.47287833
128MAP3K120.45634289
129PRKCZ0.45390664
130CAMKK20.43427581
131MAPK130.43360751
132UHMK10.42895529
133ROCK10.42791287
134PLK20.41443855
135MAPK100.40946958
136JAK20.39678088
137DDR20.38824687
138PINK10.37280186
139HIPK20.35459770
140DYRK1A0.35309722

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.36649001
2Olfactory transduction_Homo sapiens_hsa047401.97016842
3Long-term potentiation_Homo sapiens_hsa047201.85690852
4Notch signaling pathway_Homo sapiens_hsa043301.84385894
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72656528
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69007048
7Synaptic vesicle cycle_Homo sapiens_hsa047211.65641757
8Circadian entrainment_Homo sapiens_hsa047131.65506919
9Amphetamine addiction_Homo sapiens_hsa050311.64811165
10Nicotine addiction_Homo sapiens_hsa050331.64161503
11Insulin secretion_Homo sapiens_hsa049111.58144380
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54989103
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49786314
14GABAergic synapse_Homo sapiens_hsa047271.49141236
15Glutamatergic synapse_Homo sapiens_hsa047241.46121851
16Dopaminergic synapse_Homo sapiens_hsa047281.44948122
17Renin secretion_Homo sapiens_hsa049241.43603832
18B cell receptor signaling pathway_Homo sapiens_hsa046621.43211117
19Salivary secretion_Homo sapiens_hsa049701.41527437
20Dorso-ventral axis formation_Homo sapiens_hsa043201.41184112
21Morphine addiction_Homo sapiens_hsa050321.39080110
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38200665
23Gastric acid secretion_Homo sapiens_hsa049711.38109759
24Type II diabetes mellitus_Homo sapiens_hsa049301.37269932
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34944162
26Oxytocin signaling pathway_Homo sapiens_hsa049211.34422211
27Cholinergic synapse_Homo sapiens_hsa047251.31077068
28Arginine biosynthesis_Homo sapiens_hsa002201.27605726
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26463887
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26436958
31Estrogen signaling pathway_Homo sapiens_hsa049151.25537735
32Cocaine addiction_Homo sapiens_hsa050301.22634684
33Caffeine metabolism_Homo sapiens_hsa002321.22466199
34Acute myeloid leukemia_Homo sapiens_hsa052211.22307375
35Glucagon signaling pathway_Homo sapiens_hsa049221.21491822
36Glioma_Homo sapiens_hsa052141.17667324
37GnRH signaling pathway_Homo sapiens_hsa049121.15719972
38Osteoclast differentiation_Homo sapiens_hsa043801.14956677
39Dilated cardiomyopathy_Homo sapiens_hsa054141.10914956
40Bile secretion_Homo sapiens_hsa049761.10717261
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10296238
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08552988
43cAMP signaling pathway_Homo sapiens_hsa040241.04262656
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03687070
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.99224167
46mTOR signaling pathway_Homo sapiens_hsa041500.98874792
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98592302
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98120761
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97840487
50ErbB signaling pathway_Homo sapiens_hsa040120.94715846
51Long-term depression_Homo sapiens_hsa047300.94423894
52Chemokine signaling pathway_Homo sapiens_hsa040620.93562288
53Insulin signaling pathway_Homo sapiens_hsa049100.91813518
54Calcium signaling pathway_Homo sapiens_hsa040200.91623487
55Gap junction_Homo sapiens_hsa045400.91125707
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90657449
57Non-small cell lung cancer_Homo sapiens_hsa052230.89646089
58Insulin resistance_Homo sapiens_hsa049310.89551750
59Endometrial cancer_Homo sapiens_hsa052130.89416378
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88942915
61Taste transduction_Homo sapiens_hsa047420.88621997
62Hepatitis C_Homo sapiens_hsa051600.87826081
63Prostate cancer_Homo sapiens_hsa052150.84933320
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84850915
65Renal cell carcinoma_Homo sapiens_hsa052110.82959864
66VEGF signaling pathway_Homo sapiens_hsa043700.82845546
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.82669301
68Melanogenesis_Homo sapiens_hsa049160.82174720
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80555162
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.80288603
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79249847
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.79193905
73Axon guidance_Homo sapiens_hsa043600.78852661
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.78350810
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.78013552
76Circadian rhythm_Homo sapiens_hsa047100.77162646
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74601883
78Prolactin signaling pathway_Homo sapiens_hsa049170.74163663
79Adherens junction_Homo sapiens_hsa045200.73628610
80Thyroid hormone synthesis_Homo sapiens_hsa049180.73551288
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72324631
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72275043
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71263940
84Choline metabolism in cancer_Homo sapiens_hsa052310.70118165
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69946426
86Measles_Homo sapiens_hsa051620.69484446
87TNF signaling pathway_Homo sapiens_hsa046680.67635223
88Serotonergic synapse_Homo sapiens_hsa047260.67382952
89AMPK signaling pathway_Homo sapiens_hsa041520.66676345
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.66033909
91MAPK signaling pathway_Homo sapiens_hsa040100.65236983
92Toxoplasmosis_Homo sapiens_hsa051450.64747913
93Hepatitis B_Homo sapiens_hsa051610.64184254
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.62743846
95Lysine degradation_Homo sapiens_hsa003100.62693321
96Pancreatic secretion_Homo sapiens_hsa049720.60429604
97Other glycan degradation_Homo sapiens_hsa005110.60412807
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.60394661
99PPAR signaling pathway_Homo sapiens_hsa033200.59749781
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59267518
101Influenza A_Homo sapiens_hsa051640.58944268
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.58685737
103Butanoate metabolism_Homo sapiens_hsa006500.57864436
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.57733314
105Ras signaling pathway_Homo sapiens_hsa040140.57366672
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56097388
107Fatty acid biosynthesis_Homo sapiens_hsa000610.55570243
108Tight junction_Homo sapiens_hsa045300.55074525
109Proteoglycans in cancer_Homo sapiens_hsa052050.53651157
110Pancreatic cancer_Homo sapiens_hsa052120.53007541
111Endocytosis_Homo sapiens_hsa041440.52042681
112Inositol phosphate metabolism_Homo sapiens_hsa005620.51688257
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51687736
114Platelet activation_Homo sapiens_hsa046110.51524743
115Focal adhesion_Homo sapiens_hsa045100.51318630
116Chronic myeloid leukemia_Homo sapiens_hsa052200.51228787
117Fatty acid degradation_Homo sapiens_hsa000710.51202002
118Rap1 signaling pathway_Homo sapiens_hsa040150.50085890
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49996132
120Prion diseases_Homo sapiens_hsa050200.47139499
121Glycerolipid metabolism_Homo sapiens_hsa005610.46845683
122T cell receptor signaling pathway_Homo sapiens_hsa046600.46755753
123Ovarian steroidogenesis_Homo sapiens_hsa049130.45931419
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45097354
125Colorectal cancer_Homo sapiens_hsa052100.44603903
126Amoebiasis_Homo sapiens_hsa051460.44080340
127Oocyte meiosis_Homo sapiens_hsa041140.43701692
128FoxO signaling pathway_Homo sapiens_hsa040680.43064317

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