DCAF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1creatine metabolic process (GO:0006600)5.55752895
2actomyosin structure organization (GO:0031032)5.19202350
3response to muscle activity (GO:0014850)5.04271747
4NADH metabolic process (GO:0006734)4.87428418
5response to inactivity (GO:0014854)4.85178536
6muscle contraction (GO:0006936)4.81250463
7cardiac muscle hypertrophy (GO:0003300)4.66585509
8heart process (GO:0003015)4.51426302
9heart contraction (GO:0060047)4.51426302
10striated muscle hypertrophy (GO:0014897)4.44463073
11skeletal muscle fiber development (GO:0048741)4.43741830
12omega-hydroxylase P450 pathway (GO:0097267)4.32768592
13muscle system process (GO:0003012)4.31456496
14striated muscle atrophy (GO:0014891)4.15939541
15muscle tissue morphogenesis (GO:0060415)4.13139049
16myotube cell development (GO:0014904)4.13009321
17cardiac muscle tissue morphogenesis (GO:0055008)4.12315081
18striated muscle adaptation (GO:0014888)4.11597489
19muscle hypertrophy (GO:0014896)3.94063602
20skeletal muscle tissue development (GO:0007519)3.76856035
21muscle atrophy (GO:0014889)3.70725385
22sarcoplasmic reticulum calcium ion transport (GO:0070296)3.69798814
23glucan biosynthetic process (GO:0009250)3.67828459
24glycogen biosynthetic process (GO:0005978)3.67828459
25muscle fiber development (GO:0048747)3.66076559
26tricarboxylic acid cycle (GO:0006099)3.63656125
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.59721442
28neuronal action potential propagation (GO:0019227)3.54006216
29regulation of the force of heart contraction (GO:0002026)3.53320492
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.51323055
31regulation of cell communication by electrical coupling (GO:0010649)3.50471782
322-oxoglutarate metabolic process (GO:0006103)3.45021160
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41261641
34carnitine shuttle (GO:0006853)3.40674609
35muscle adaptation (GO:0043500)3.32295926
36plasma membrane repair (GO:0001778)3.30691930
37muscle cell cellular homeostasis (GO:0046716)3.30235519
38positive regulation of myotube differentiation (GO:0010831)3.29444483
39regulation of skeletal muscle contraction (GO:0014819)3.28041065
40cardiac muscle adaptation (GO:0014887)3.27781293
41cardiac muscle hypertrophy in response to stress (GO:0014898)3.27781293
42muscle hypertrophy in response to stress (GO:0003299)3.27781293
43sperm motility (GO:0030317)3.22832535
44cardiac muscle cell development (GO:0055013)3.20882397
45muscle filament sliding (GO:0030049)3.19125069
46actin-myosin filament sliding (GO:0033275)3.19125069
47ventricular cardiac muscle cell action potential (GO:0086005)3.17920121
48ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.17541187
49negative regulation of protein localization to cell surface (GO:2000009)3.16907547
50fructose metabolic process (GO:0006000)3.16652634
51skeletal muscle tissue regeneration (GO:0043403)3.16357972
52response to epinephrine (GO:0071871)3.15273200
53fatty acid transmembrane transport (GO:1902001)3.14560522
54carnitine transmembrane transport (GO:1902603)3.13681057
55glycogen metabolic process (GO:0005977)3.12895561
56muscle cell fate commitment (GO:0042693)3.12804245
57acrosome reaction (GO:0007340)3.11107209
58striated muscle cell development (GO:0055002)3.10476693
59cellular response to epinephrine stimulus (GO:0071872)3.10370261
60gluconeogenesis (GO:0006094)3.07086687
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06173771
62cellular glucan metabolic process (GO:0006073)3.06067521
63glucan metabolic process (GO:0044042)3.06067521
64positive regulation of cation channel activity (GO:2001259)3.05909898
65negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04113179
66oxaloacetate metabolic process (GO:0006107)3.02354101
67carnitine transport (GO:0015879)3.01679157
68amino-acid betaine transport (GO:0015838)3.01679157
69regulation of muscle system process (GO:0090257)2.96365320
70relaxation of muscle (GO:0090075)2.95159886
71cardiac cell development (GO:0055006)2.93297680
72regulation of ATPase activity (GO:0043462)2.91483183
73regulation of ATP catabolic process (GO:1903289)2.91483183
74muscle organ development (GO:0007517)2.89440220
75adult heart development (GO:0007512)2.88719598
76glycogen catabolic process (GO:0005980)2.88456181
77muscle structure development (GO:0061061)2.87424199
78macroautophagy (GO:0016236)2.87033207
79regulation of relaxation of muscle (GO:1901077)2.86175947
80myoblast fusion (GO:0007520)2.85849972
81synaptic vesicle maturation (GO:0016188)2.85501250
82acrosome assembly (GO:0001675)2.77170572
83regulation of actin filament-based movement (GO:1903115)2.75106432
84membrane depolarization during action potential (GO:0086010)2.74018664
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73919819
86skeletal muscle contraction (GO:0003009)2.73361421
87glucan catabolic process (GO:0009251)2.69191772
88regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.67972186
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67661406
90fusion of sperm to egg plasma membrane (GO:0007342)2.67435554
91cilium or flagellum-dependent cell motility (GO:0001539)2.67084937
92regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.66792726
93negative regulation of potassium ion transmembrane transport (GO:1901380)2.65583708
94negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65506057
95actin-mediated cell contraction (GO:0070252)2.65119687
96regulation of calcium ion transmembrane transport (GO:1903169)2.64292891
97regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64292891
98activation of protein kinase A activity (GO:0034199)2.58843077
99myofibril assembly (GO:0030239)2.55090512
100presynaptic membrane assembly (GO:0097105)2.54997717
101cAMP catabolic process (GO:0006198)2.53396441
102skeletal muscle adaptation (GO:0043501)2.52059565
103detection of calcium ion (GO:0005513)2.49144044
104neurotransmitter-gated ion channel clustering (GO:0072578)2.46232360
105vocalization behavior (GO:0071625)2.45668796
106fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45384249
107cell communication involved in cardiac conduction (GO:0086065)2.45222031
108calcium ion import (GO:0070509)2.44417915
109calcium ion-dependent exocytosis (GO:0017156)2.44384075
110cellular polysaccharide catabolic process (GO:0044247)2.43678196
111striated muscle contraction (GO:0006941)2.43222132
112regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.42622840
113plasma membrane fusion (GO:0045026)2.40638000
114sarcomere organization (GO:0045214)2.37833046
115regulation of ARF protein signal transduction (GO:0032012)2.37473108
116positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.35881947
117sperm capacitation (GO:0048240)2.33903732
118regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.32902283
119regulation of cardiac muscle cell contraction (GO:0086004)2.31821659
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.30895769
121polysaccharide catabolic process (GO:0000272)2.30116741
122quaternary ammonium group transport (GO:0015697)2.30113508
123response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.29249889
124L-phenylalanine catabolic process (GO:0006559)2.28688623
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28688623
126regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28462445
127establishment of protein localization to Golgi (GO:0072600)2.28000080
128cell communication by electrical coupling (GO:0010644)2.27994593
129protein targeting to Golgi (GO:0000042)2.27481811
130cardiac muscle contraction (GO:0060048)2.26866891
131protein localization to synapse (GO:0035418)2.25613416
132postsynaptic membrane organization (GO:0001941)2.24277789
133urea cycle (GO:0000050)2.24069778
134urea metabolic process (GO:0019627)2.24069778
135cyclic nucleotide catabolic process (GO:0009214)2.23940189
136regulation of striated muscle contraction (GO:0006942)2.23717848
137cardiac myofibril assembly (GO:0055003)2.21699521
138regulation of glutamate receptor signaling pathway (GO:1900449)2.21341921
139negative regulation of inclusion body assembly (GO:0090084)2.20605014
140regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.20299517
141regulation of sequestering of triglyceride (GO:0010889)2.19569313
142negative regulation of calcium ion transmembrane transport (GO:1903170)2.19067005
143negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.19067005
144cell wall macromolecule catabolic process (GO:0016998)2.17984416
145cell wall macromolecule metabolic process (GO:0044036)2.17984416
146multicellular organism reproduction (GO:0032504)2.17918893
147presynaptic membrane organization (GO:0097090)2.17836389
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.17725636
149regulation of membrane repolarization (GO:0060306)2.17289316
150regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.16807283
151regulation of synaptic vesicle exocytosis (GO:2000300)2.14968873
152regulation of cation channel activity (GO:2001257)2.13893781
153regulation of acyl-CoA biosynthetic process (GO:0050812)2.13625554
154N-acetylneuraminate metabolic process (GO:0006054)2.13564215
155actin filament-based movement (GO:0030048)2.13175555
156locomotory exploration behavior (GO:0035641)2.11863615
157regulation of voltage-gated calcium channel activity (GO:1901385)2.09568536
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.08619769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46007622
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.06174400
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.06012269
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91631773
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.46230857
6GBX2_23144817_ChIP-Seq_PC3_Human2.46102158
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29054329
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.23126013
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.22927800
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20316108
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.18054429
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09132502
13CLOCK_20551151_ChIP-Seq_293T_Human2.07584362
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88511114
15GATA4_21415370_ChIP-Seq_HL-1_Mouse1.87086915
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85771311
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85156273
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81526513
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81128452
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81128452
21ZNF263_19887448_ChIP-Seq_K562_Human1.79361859
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78110742
23DROSHA_22980978_ChIP-Seq_HELA_Human1.73560881
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.72439494
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69287511
26GATA1_22025678_ChIP-Seq_K562_Human1.69093275
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.66541936
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60098307
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.59805391
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58941340
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58615565
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55631309
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.55619140
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.54945264
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51927409
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49413261
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.48204191
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47868442
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47631912
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.46002099
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.44829361
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44479258
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44134056
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.43653719
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43466399
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42847541
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.40799856
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39046185
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.37442687
50REST_21632747_ChIP-Seq_MESCs_Mouse1.35356588
51GATA1_19941826_ChIP-Seq_K562_Human1.34687844
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.34099779
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32277148
54ZNF274_21170338_ChIP-Seq_K562_Hela1.31641570
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30263170
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.29593257
57AR_21572438_ChIP-Seq_LNCaP_Human1.23953007
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.22853842
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.22528575
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.22281566
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22061242
62* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22007984
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22001935
64CJUN_26792858_Chip-Seq_BT549_Human1.21578314
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21409669
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19950731
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19593892
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18204546
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.17253237
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16696653
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16675518
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15918318
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15725611
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15643360
75GATA2_19941826_ChIP-Seq_K562_Human1.15497265
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14590415
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14402740
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11129960
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08837708
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08487270
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08166332
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08164818
83TAF15_26573619_Chip-Seq_HEK293_Human1.07613411
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07027025
85* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06716900
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06276970
87BCAT_22108803_ChIP-Seq_LS180_Human1.06113533
88STAT3_23295773_ChIP-Seq_U87_Human1.05930211
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03891524
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.03631389
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.03561418
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03181784
93* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01937900
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.01452806
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01023338
96TCF4_23295773_ChIP-Seq_U87_Human1.00877121
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00198884
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99425680
99AR_25329375_ChIP-Seq_VCAP_Human0.98642157
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98129123
101WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97905942
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.97884662
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97426584
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96587389
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.95891636
106RACK7_27058665_Chip-Seq_MCF-7_Human0.94974402
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94912703
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94638808
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94638808
110SOX2_21211035_ChIP-Seq_LN229_Gbm0.94255498
111FOXA2_19822575_ChIP-Seq_HepG2_Human0.94137751
112CTCF_27219007_Chip-Seq_Bcells_Human0.94131364
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.93937625
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.93937625
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.93903601
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93376883
117KDM2B_26808549_Chip-Seq_REH_Human0.92938273
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92883924
119REST_18959480_ChIP-ChIP_MESCs_Mouse0.92241014
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92115616
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.91535351
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90838843
123AR_19668381_ChIP-Seq_PC3_Human0.90562740
124AHR_22903824_ChIP-Seq_MCF-7_Human0.90480318
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90468227
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90051425
127* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89857853
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89175850
129ER_23166858_ChIP-Seq_MCF-7_Human0.88884171
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.88700848
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88652906
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87833784
133CBP_20019798_ChIP-Seq_JUKART_Human0.87512736
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87512736
135TP53_18474530_ChIP-ChIP_U2OS_Human0.87261561
136* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86023261
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85836229
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85168925
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84820107
140* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84780429
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84218233
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84146443
143P300_19829295_ChIP-Seq_ESCs_Human0.83463444
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83335463
145* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83282935
146* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83269395
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83046504
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83046504
149* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82831615
150RING1B_27294783_Chip-Seq_ESCs_Mouse0.82829518
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82819713
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82809977
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82753373
154* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81542500
155CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79288866
156YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78232413
157AR_21909140_ChIP-Seq_LNCAP_Human0.77411608
158KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.76508651
159* CRX_20693478_ChIP-Seq_RETINA_Mouse0.76289578
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76079211
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75417316
162GF1_26923725_Chip-Seq_HPCs_Mouse0.74634361
163* EZH2_27294783_Chip-Seq_NPCs_Mouse0.74584884
164TCF4_18268006_ChIP-ChIP_LS174T_Human0.72773100
165STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.72654174
166* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.72491153
167SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72076136
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71412909
169TP53_23651856_ChIP-Seq_MEFs_Mouse0.70621570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.74163151
2MP0002837_dystrophic_cardiac_calcinosis3.62512391
3MP0004145_abnormal_muscle_electrophysio3.60075058
4MP0000751_myopathy3.42132968
5MP0005451_abnormal_body_composition3.38121520
6MP0000749_muscle_degeneration3.18664388
7MP0005410_abnormal_fertilization3.09480544
8MP0002139_abnormal_hepatobiliary_system3.01716361
9MP0004859_abnormal_synaptic_plasticity2.84793988
10MP0004130_abnormal_muscle_cell2.75660315
11MP0002332_abnormal_exercise_endurance2.49521228
12MP0004036_abnormal_muscle_relaxation2.41500118
13MP0004270_analgesia2.26187704
14MP0005360_urolithiasis2.08667267
15MP0005085_abnormal_gallbladder_physiolo2.07637506
16MP0009780_abnormal_chondrocyte_physiolo1.97209583
17MP0000747_muscle_weakness1.92020486
18MP0003195_calcinosis1.91225778
19MP0000733_abnormal_muscle_development1.89157116
20MP0008438_abnormal_cutaneous_collagen1.82398405
21MP0005620_abnormal_muscle_contractility1.78851491
22MP0003635_abnormal_synaptic_transmissio1.78800106
23MP0004087_abnormal_muscle_fiber1.73928850
24MP0004215_abnormal_myocardial_fiber1.69130986
25MP0003252_abnormal_bile_duct1.68292909
26MP0002106_abnormal_muscle_physiology1.66823760
27MP0000759_abnormal_skeletal_muscle1.66106001
28MP0005409_darkened_coat_color1.64311021
29MP0005365_abnormal_bile_salt1.63461548
30MP0002876_abnormal_thyroid_physiology1.60361542
31MP0003950_abnormal_plasma_membrane1.57233084
32MP0005670_abnormal_white_adipose1.55029914
33MP0004084_abnormal_cardiac_muscle1.54047066
34MP0009745_abnormal_behavioral_response1.50031767
35MP0003828_pulmonary_edema1.48706842
36MP0003705_abnormal_hypodermis_morpholog1.48702076
37MP0005666_abnormal_adipose_tissue1.48007141
38MP0002127_abnormal_cardiovascular_syste1.47902147
39MP0002269_muscular_atrophy1.47548936
40MP0003880_abnormal_central_pattern1.45988035
41MP0002909_abnormal_adrenal_gland1.44772346
42MP0005369_muscle_phenotype1.41780775
43MP0002735_abnormal_chemical_nociception1.41676276
44MP0005330_cardiomyopathy1.39034314
45MP0003221_abnormal_cardiomyocyte_apopto1.35248980
46MP0009046_muscle_twitch1.35227039
47MP0008569_lethality_at_weaning1.33230373
48MP0003868_abnormal_feces_composition1.31543120
49MP0004484_altered_response_of1.30403989
50MP0002822_catalepsy1.26064733
51MP0004043_abnormal_pH_regulation1.25440137
52MP0003879_abnormal_hair_cell1.25279379
53MP0002063_abnormal_learning/memory/cond1.22882120
54MP0010329_abnormal_lipoprotein_level1.22441231
55MP0001968_abnormal_touch/_nociception1.20945194
56MP0001188_hyperpigmentation1.20794948
57MP0002972_abnormal_cardiac_muscle1.19367522
58MP0003136_yellow_coat_color1.18555699
59MP0002272_abnormal_nervous_system1.18537414
60MP0002064_seizures1.17005197
61MP0000013_abnormal_adipose_tissue1.14231840
62MP0008875_abnormal_xenobiotic_pharmacok1.13729985
63MP0005266_abnormal_metabolism1.12967976
64MP0002971_abnormal_brown_adipose1.12275635
65MP0000003_abnormal_adipose_tissue1.11645273
66MP0003698_abnormal_male_reproductive1.11617394
67MP0005535_abnormal_body_temperature1.10654147
68MP0003045_fibrosis1.10486837
69MP0005375_adipose_tissue_phenotype1.08503914
70MP0002078_abnormal_glucose_homeostasis1.07574861
71MP0004085_abnormal_heartbeat1.05940533
72MP0005275_abnormal_skin_tensile1.05243456
73MP0002734_abnormal_mechanical_nocicepti1.04902453
74MP0003656_abnormal_erythrocyte_physiolo1.04622706
75MP0003137_abnormal_impulse_conducting1.04451417
76MP0004233_abnormal_muscle_weight1.03410931
77MP0002067_abnormal_sensory_capabilities1.03044319
78MP0003633_abnormal_nervous_system1.02240706
79MP0001486_abnormal_startle_reflex1.02015979
80MP0009840_abnormal_foam_cell0.99838017
81MP0002118_abnormal_lipid_homeostasis0.98800705
82MP0001765_abnormal_ion_homeostasis0.97609340
83MP0002572_abnormal_emotion/affect_behav0.97294029
84MP0005332_abnormal_amino_acid0.95704967
85MP0002108_abnormal_muscle_morphology0.93524266
86MP0002557_abnormal_social/conspecific_i0.86217514
87MP0005623_abnormal_meninges_morphology0.85296851
88MP0005334_abnormal_fat_pad0.84789320
89MP0006036_abnormal_mitochondrial_physio0.84016568
90MP0008874_decreased_physiological_sensi0.83225511
91MP0000750_abnormal_muscle_regeneration0.82841430
92MP0008775_abnormal_heart_ventricle0.82627918
93MP0004147_increased_porphyrin_level0.81774709
94MP0002138_abnormal_hepatobiliary_system0.81548593
95MP0006138_congestive_heart_failure0.81398434
96MP0002009_preneoplasia0.80820558
97MP0005171_absent_coat_pigmentation0.79521839
98MP0004185_abnormal_adipocyte_glucose0.78826249
99MP0001544_abnormal_cardiovascular_syste0.77721287
100MP0005385_cardiovascular_system_phenoty0.77721287
101MP0008961_abnormal_basal_metabolism0.77713868
102MP0001970_abnormal_pain_threshold0.76899906
103MP0000266_abnormal_heart_morphology0.75574766
104MP0000372_irregular_coat_pigmentation0.75529430
105MP0005165_increased_susceptibility_to0.75207757
106MP0000230_abnormal_systemic_arterial0.73391856
107MP0003566_abnormal_cell_adhesion0.73053256
108MP0002896_abnormal_bone_mineralization0.72856889
109MP0002733_abnormal_thermal_nociception0.72600600
110MP0004272_abnormal_basement_membrane0.72369206
111MP0010630_abnormal_cardiac_muscle0.72254076
112MP0005167_abnormal_blood-brain_barrier0.71683085
113MP0003279_aneurysm0.71677060
114MP0008260_abnormal_autophagy0.71497247
115MP0001661_extended_life_span0.68465388
116MP0004510_myositis0.67854870
117MP0005584_abnormal_enzyme/coenzyme_acti0.66086041
118MP0010368_abnormal_lymphatic_system0.65640132
119MP0003329_amyloid_beta_deposits0.65225257
120MP0002128_abnormal_blood_circulation0.63193199
121MP0005503_abnormal_tendon_morphology0.62987780
122MP0008004_abnormal_stomach_pH0.60346203
123MP0003191_abnormal_cellular_cholesterol0.59690367
124MP0001958_emphysema0.59690079
125MP0005083_abnormal_biliary_tract0.59386687
126MP0003941_abnormal_skin_development0.58238528
127MP0002877_abnormal_melanocyte_morpholog0.54356798
128MP0004134_abnormal_chest_morphology0.53066133
129MP0001299_abnormal_eye_distance/0.52871122
130MP0000343_altered_response_to0.48462360
131MP0003091_abnormal_cell_migration0.47222561
132MP0005166_decreased_susceptibility_to0.44374431
133MP0002168_other_aberrant_phenotype0.43015780
134MP0005376_homeostasis/metabolism_phenot0.41189256
135MP0009384_cardiac_valve_regurgitation0.37260837
136MP0000767_abnormal_smooth_muscle0.35013825
137MP0000762_abnormal_tongue_morphology0.34940834
138MP0005023_abnormal_wound_healing0.33276342
139MP0005319_abnormal_enzyme/_coenzyme0.32686940
140MP0003806_abnormal_nucleotide_metabolis0.32136394
141MP0005058_abnormal_lysosome_morphology0.31943411
142MP0004858_abnormal_nervous_system0.27726664
143MP0003959_abnormal_lean_body0.27672763

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.59322879
2Muscle hypertrophy of the lower extremities (HP:0008968)4.63438808
3Exercise-induced muscle cramps (HP:0003710)4.46111343
4Calf muscle hypertrophy (HP:0008981)4.45803935
5Muscle fiber inclusion bodies (HP:0100299)4.45787075
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.32041150
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.24491728
8Neck muscle weakness (HP:0000467)4.15891484
9Hyporeflexia of lower limbs (HP:0002600)3.97067906
10Type 1 muscle fiber predominance (HP:0003803)3.94191523
11Distal lower limb muscle weakness (HP:0009053)3.85711152
12Rimmed vacuoles (HP:0003805)3.76737333
13Sudden death (HP:0001699)3.75773757
14Absent/shortened dynein arms (HP:0200106)3.72432031
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.72432031
16Difficulty running (HP:0009046)3.67360799
17Myoglobinuria (HP:0002913)3.62434954
18Focal motor seizures (HP:0011153)3.59059334
19Nemaline bodies (HP:0003798)3.57342816
20Muscle fiber splitting (HP:0003555)3.43207220
21Calcaneovalgus deformity (HP:0001848)3.42330308
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30319686
23Frequent falls (HP:0002359)3.25533453
24Abnormality of the calf musculature (HP:0001430)3.20553898
25EMG: myopathic abnormalities (HP:0003458)3.20246576
26Increased variability in muscle fiber diameter (HP:0003557)3.17772753
27Agitation (HP:0000713)3.07750808
28Distal arthrogryposis (HP:0005684)3.06476993
29Hyperkalemia (HP:0002153)2.99964031
30Deformed tarsal bones (HP:0008119)2.98834456
31Abnormality of skeletal muscle fiber size (HP:0012084)2.94854048
32Areflexia of lower limbs (HP:0002522)2.85047418
33Myotonia (HP:0002486)2.81378471
34Asymmetric septal hypertrophy (HP:0001670)2.76982920
35Muscle stiffness (HP:0003552)2.74986162
36Bundle branch block (HP:0011710)2.74560567
37Testicular atrophy (HP:0000029)2.70345020
38Abnormality of the left ventricular outflow tract (HP:0011103)2.63914681
39Subaortic stenosis (HP:0001682)2.63914681
40Malignant hyperthermia (HP:0002047)2.62903135
41Increased connective tissue (HP:0009025)2.61354036
42Scapular winging (HP:0003691)2.54583908
43Hypercortisolism (HP:0001578)2.53743301
44Action tremor (HP:0002345)2.53637112
45Spinal rigidity (HP:0003306)2.51336267
46Dysmetric saccades (HP:0000641)2.49929180
47Limb-girdle muscle atrophy (HP:0003797)2.48019639
48Ketoacidosis (HP:0001993)2.47128612
49Generalized muscle weakness (HP:0003324)2.47111794
50Ketosis (HP:0001946)2.44659613
51Hyperinsulinemic hypoglycemia (HP:0000825)2.44617862
52Round ear (HP:0100830)2.39502598
53Abnormal respiratory motile cilium physiology (HP:0012261)2.37093737
54Myopathic facies (HP:0002058)2.36117963
55Depression (HP:0000716)2.35768584
56Gaze-evoked nystagmus (HP:0000640)2.35602568
57Hypoglycemic coma (HP:0001325)2.33446373
58Atrial fibrillation (HP:0005110)2.32670129
59Ventricular arrhythmia (HP:0004308)2.31150929
60Slender build (HP:0001533)2.29746529
61Gowers sign (HP:0003391)2.27922518
62Nonprogressive disorder (HP:0003680)2.27647667
63Abnormality of the foot musculature (HP:0001436)2.26280493
64Late onset (HP:0003584)2.26199911
65Difficulty climbing stairs (HP:0003551)2.23312286
66Focal seizures (HP:0007359)2.20280377
67Foot dorsiflexor weakness (HP:0009027)2.19660077
68Ventricular tachycardia (HP:0004756)2.18707088
69Mildly elevated creatine phosphokinase (HP:0008180)2.16364930
70Atrioventricular block (HP:0001678)2.14781933
71Syncope (HP:0001279)2.13323507
72Primary atrial arrhythmia (HP:0001692)2.13011387
73Progressive muscle weakness (HP:0003323)2.10427962
74Rhabdomyolysis (HP:0003201)2.10059221
75Heart block (HP:0012722)2.09304536
76Impaired proprioception (HP:0010831)2.08912788
77Fetal akinesia sequence (HP:0001989)2.06271466
78Hypoalphalipoproteinemia (HP:0003233)2.05653173
79Infertility (HP:0000789)2.03676631
80Weak cry (HP:0001612)2.02599750
81Abnormality of the calcaneus (HP:0008364)2.02589470
82Right ventricular cardiomyopathy (HP:0011663)2.02330772
83Prolonged QT interval (HP:0001657)2.01042060
84Lower limb hyperreflexia (HP:0002395)2.00768212
85Myokymia (HP:0002411)2.00570840
86Anxiety (HP:0000739)2.00538477
87Hip contracture (HP:0003273)1.99213837
88EMG: neuropathic changes (HP:0003445)1.97861052
89Abnormal atrioventricular conduction (HP:0005150)1.97298935
90Prolonged partial thromboplastin time (HP:0003645)1.93777644
91Supraventricular tachycardia (HP:0004755)1.91538314
92Progressive cerebellar ataxia (HP:0002073)1.91452218
93Hyperglycinuria (HP:0003108)1.90130677
94Fatigable weakness (HP:0003473)1.89616442
95Abnormality of the neuromuscular junction (HP:0003398)1.89616442
96Febrile seizures (HP:0002373)1.89033957
97Lipoatrophy (HP:0100578)1.88677852
98Dilated cardiomyopathy (HP:0001644)1.88155210
99Deep venous thrombosis (HP:0002625)1.87849563
100Supraventricular arrhythmia (HP:0005115)1.87785165
101Abnormal ciliary motility (HP:0012262)1.86433680
102Abnormal respiratory epithelium morphology (HP:0012253)1.86103857
103Abnormal respiratory motile cilium morphology (HP:0005938)1.86103857
104Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86062500
105Cholelithiasis (HP:0001081)1.84369711
106Abnormality of the shoulder girdle musculature (HP:0001435)1.83385221
107Insulin-resistant diabetes mellitus (HP:0000831)1.82935887
108Absent phalangeal crease (HP:0006109)1.82155149
109Termporal pattern (HP:0011008)1.81859671
110Insidious onset (HP:0003587)1.81859671
111Abnormal finger flexion creases (HP:0006143)1.81726435
112Visual hallucinations (HP:0002367)1.80780555
113Bulbar palsy (HP:0001283)1.80028538
114Ulnar deviation of the wrist (HP:0003049)1.79527088
115Broad-based gait (HP:0002136)1.79436557
116Impaired vibratory sensation (HP:0002495)1.78942123
117Ragged-red muscle fibers (HP:0003200)1.78472047
118Popliteal pterygium (HP:0009756)1.78267099
119Hyperglycemia (HP:0003074)1.77726883
120Restlessness (HP:0000711)1.76412589
121Proximal amyotrophy (HP:0007126)1.75616078
122Hyperglycinemia (HP:0002154)1.75074525
123Distal lower limb amyotrophy (HP:0008944)1.75041104
124Genetic anticipation (HP:0003743)1.74846135
125Generalized tonic-clonic seizures (HP:0002069)1.74267050
126Lower limb amyotrophy (HP:0007210)1.73628631
127Muscular dystrophy (HP:0003560)1.73591993
128Abnormal gallbladder morphology (HP:0012437)1.72302514
129Facial diplegia (HP:0001349)1.71520012
130Limb-girdle muscle weakness (HP:0003325)1.70095956
131Rhinitis (HP:0012384)1.69887993
132Waddling gait (HP:0002515)1.69205682
133Ventricular fibrillation (HP:0001663)1.66936085
134Respiratory insufficiency due to muscle weakness (HP:0002747)1.65235374
135Metatarsus adductus (HP:0001840)1.60637168
136Achilles tendon contracture (HP:0001771)1.54579586
137Pelvic girdle muscle weakness (HP:0003749)1.53462219
138Abnormality of the hip-girdle musculature (HP:0001445)1.52816421
139Abnormality of the musculature of the pelvis (HP:0001469)1.52816421
140Abnormality of the Achilles tendon (HP:0005109)1.52143517
141Palpitations (HP:0001962)1.51716832
142Protrusio acetabuli (HP:0003179)1.51045038
143Long clavicles (HP:0000890)1.47710021
144Limited hip movement (HP:0008800)1.46468657
145Paralysis (HP:0003470)1.45098132
146Back pain (HP:0003418)1.44280098
147Shoulder girdle muscle weakness (HP:0003547)1.44204293
148Abnormality of fatty-acid metabolism (HP:0004359)1.43632305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK33.58104542
2PDK43.58104542
3PRKD33.06219649
4OBSCN3.02900876
5PHKG12.56922431
6PHKG22.56922431
7INSRR2.42076750
8TTN2.23922964
9CASK2.21186076
10PDK22.11285779
11PINK12.09963732
12NTRK32.08932647
13STK382.06289075
14DAPK21.96972330
15TRPM71.87820143
16EPHA41.87382501
17NEK91.86093684
18MAP2K31.67897445
19PTK2B1.61865993
20MAPKAPK31.61683969
21MAPK121.61648050
22MAP2K41.58890889
23WNK41.57718597
24PRKD21.54975737
25EEF2K1.52322941
26MYLK1.37282851
27MAP2K71.35740996
28MAPK131.34624489
29TNIK1.33548862
30MUSK1.29970058
31DMPK1.27335779
32LMTK21.25046826
33MAP3K71.23924320
34NEK11.22956987
35MAP3K41.21671684
36LATS21.20044128
37PRPF4B1.18171311
38FER1.17443350
39SGK21.16509392
40BCKDK1.15264550
41FES1.12498679
42WNK11.11846682
43CAMKK11.08253181
44CAMK11.06071860
45TRIB31.05068848
46PIK3CG1.04734952
47SGK31.03842770
48PAK60.97659363
49MOS0.96851042
50SGK4940.96356375
51SGK2230.96356375
52SIK10.95171085
53CAMK1G0.94250243
54RIPK40.93756070
55FRK0.91831810
56STK390.89962387
57CCNB10.89830518
58ROCK10.89082798
59MAPK110.88135394
60PRKAA10.87366768
61CAMKK20.86450554
62PDK10.85785082
63PRKAA20.84074324
64TIE10.83907547
65MAP2K10.83510856
66ICK0.83483874
67LIMK10.83421842
68MAP3K10.82974062
69MAP3K130.82089693
70PDGFRA0.81553085
71PDPK10.81433245
72NTRK10.81008734
73MINK10.80025860
74GRK50.79644380
75STK110.78633479
76ERBB30.78408796
77SCYL20.77209611
78CAMK2A0.76729230
79LATS10.76040283
80PRKCH0.75171937
81KSR20.71283026
82TESK10.69441941
83SGK10.69277271
84MAP3K50.69237807
85RET0.68486372
86DAPK30.67827977
87ARAF0.66868108
88MAPK70.66400076
89MAP3K20.66317907
90MAPK150.65252382
91PRKD10.64617667
92RAF10.63968343
93CDK50.63582072
94IRAK30.62770912
95AKT30.62600156
96PIK3CA0.62135538
97TNK20.61482597
98AKT20.61128381
99MAP2K60.59644973
100ERN10.57072377
101MAPK40.56937561
102PRKCG0.54675821
103TBK10.53248558
104TAOK20.53215211
105FGFR20.51904415
106PKN20.51576400
107MAP3K120.51465365
108MAP3K30.50443214
109MARK10.49895343
110MST1R0.48782957
111HIPK20.48490548
112PAK30.48481339
113MARK20.47917974
114EIF2AK10.46719050
115MAP3K60.45860970
116CAMK40.45716621
117CAMK2G0.45361329
118CAMK2D0.45193308
119JAK20.45010734
120TGFBR20.44845486
121MTOR0.44712333
122NME10.44627825
123RIPK10.44495248
124CAMK2B0.43976304
125IRAK20.43086824
126UHMK10.42438519
127PRKACA0.42231722
128DDR20.41147265
129MET0.40901104
130NTRK20.40766676
131KSR10.40477902
132RPS6KA30.39921395
133PRKACG0.37760309
134MAPK100.37191669
135PRKCZ0.36755789
136PRKG10.36123320
137DYRK1B0.36112151
138JAK10.35564131
139TAOK10.34694786
140SIK20.34348464
141CDC42BPA0.33882767
142PAK20.29424386
143ROCK20.29142174
144PTK20.27894124
145RPS6KB10.26191701
146PKN10.21167078

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006401.88677068
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84426755
3Arginine and proline metabolism_Homo sapiens_hsa003301.74349675
4Phenylalanine metabolism_Homo sapiens_hsa003601.74119252
5Fatty acid degradation_Homo sapiens_hsa000711.71383636
6Arginine biosynthesis_Homo sapiens_hsa002201.69961425
7Nitrogen metabolism_Homo sapiens_hsa009101.69008989
8Insulin secretion_Homo sapiens_hsa049111.67696939
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.54733382
10Glucagon signaling pathway_Homo sapiens_hsa049221.53028613
11Circadian entrainment_Homo sapiens_hsa047131.42368658
12Pentose phosphate pathway_Homo sapiens_hsa000301.41728141
13Long-term potentiation_Homo sapiens_hsa047201.39352948
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37003423
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36154491
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34866467
17PPAR signaling pathway_Homo sapiens_hsa033201.34212888
18Salivary secretion_Homo sapiens_hsa049701.33573365
19Dilated cardiomyopathy_Homo sapiens_hsa054141.33481371
20Fatty acid metabolism_Homo sapiens_hsa012121.32779055
21Cardiac muscle contraction_Homo sapiens_hsa042601.32475156
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32162056
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31866634
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29939562
25Renin secretion_Homo sapiens_hsa049241.28233668
26Calcium signaling pathway_Homo sapiens_hsa040201.27530415
27Glutamatergic synapse_Homo sapiens_hsa047241.26064508
28Olfactory transduction_Homo sapiens_hsa047401.25920255
29Fructose and mannose metabolism_Homo sapiens_hsa000511.25186737
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24921931
31Morphine addiction_Homo sapiens_hsa050321.23290495
32Focal adhesion_Homo sapiens_hsa045101.20829121
33Amphetamine addiction_Homo sapiens_hsa050311.20109337
34Oxytocin signaling pathway_Homo sapiens_hsa049211.19843608
35Bile secretion_Homo sapiens_hsa049761.19538028
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18625705
37Starch and sucrose metabolism_Homo sapiens_hsa005001.18235192
38Gastric acid secretion_Homo sapiens_hsa049711.18207482
39Pyruvate metabolism_Homo sapiens_hsa006201.17074118
40Nicotine addiction_Homo sapiens_hsa050331.13328923
41Biosynthesis of amino acids_Homo sapiens_hsa012301.13219909
42Butanoate metabolism_Homo sapiens_hsa006501.12801199
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12414358
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10525714
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09387265
46Fatty acid biosynthesis_Homo sapiens_hsa000611.09332330
47GABAergic synapse_Homo sapiens_hsa047271.08485325
48Type II diabetes mellitus_Homo sapiens_hsa049301.08043882
49Taste transduction_Homo sapiens_hsa047421.06969404
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03704261
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03571938
52Cholinergic synapse_Homo sapiens_hsa047251.02496285
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01878464
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99784572
55ABC transporters_Homo sapiens_hsa020100.98527567
56Synaptic vesicle cycle_Homo sapiens_hsa047210.97900023
57Tryptophan metabolism_Homo sapiens_hsa003800.97049205
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96862546
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.96769927
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96346217
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94857800
62Dorso-ventral axis formation_Homo sapiens_hsa043200.93595099
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.88816246
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88507480
65cAMP signaling pathway_Homo sapiens_hsa040240.88465599
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88338813
67Insulin signaling pathway_Homo sapiens_hsa049100.88231696
68Dopaminergic synapse_Homo sapiens_hsa047280.87508035
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83851146
70Amoebiasis_Homo sapiens_hsa051460.83202984
71Tight junction_Homo sapiens_hsa045300.83165247
72Insulin resistance_Homo sapiens_hsa049310.83034126
73Circadian rhythm_Homo sapiens_hsa047100.82130541
74Glycerolipid metabolism_Homo sapiens_hsa005610.79843249
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79003711
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78907151
77ECM-receptor interaction_Homo sapiens_hsa045120.78714743
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.78314642
79Pancreatic secretion_Homo sapiens_hsa049720.77786870
80Histidine metabolism_Homo sapiens_hsa003400.76516186
81GnRH signaling pathway_Homo sapiens_hsa049120.76102539
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.76083692
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75131043
84Long-term depression_Homo sapiens_hsa047300.74320955
85Complement and coagulation cascades_Homo sapiens_hsa046100.74015003
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72638973
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71115296
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70534922
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70275526
90Peroxisome_Homo sapiens_hsa041460.70108319
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69841337
92Tyrosine metabolism_Homo sapiens_hsa003500.67975045
93AMPK signaling pathway_Homo sapiens_hsa041520.64104615
94beta-Alanine metabolism_Homo sapiens_hsa004100.64067629
95Melanogenesis_Homo sapiens_hsa049160.63663326
96Fat digestion and absorption_Homo sapiens_hsa049750.62538881
97Carbon metabolism_Homo sapiens_hsa012000.62485011
98VEGF signaling pathway_Homo sapiens_hsa043700.62117262
99Ovarian steroidogenesis_Homo sapiens_hsa049130.58830732
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58362572
101Fatty acid elongation_Homo sapiens_hsa000620.57973676
102Thyroid hormone synthesis_Homo sapiens_hsa049180.57288630
103Galactose metabolism_Homo sapiens_hsa000520.56724307
104Adherens junction_Homo sapiens_hsa045200.55258072
105Serotonergic synapse_Homo sapiens_hsa047260.53968476
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53579132
107Alzheimers disease_Homo sapiens_hsa050100.53101867
108mTOR signaling pathway_Homo sapiens_hsa041500.52860402
109Sulfur metabolism_Homo sapiens_hsa009200.52595226
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.51758718
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51655820
112Phototransduction_Homo sapiens_hsa047440.51437138
113Renal cell carcinoma_Homo sapiens_hsa052110.50909600
114Chemical carcinogenesis_Homo sapiens_hsa052040.50496870
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50468236
116Prion diseases_Homo sapiens_hsa050200.49954020
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49428084
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49324213
119Lysine degradation_Homo sapiens_hsa003100.48124930
120Estrogen signaling pathway_Homo sapiens_hsa049150.47346829
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47159784
122Gap junction_Homo sapiens_hsa045400.45495719
123FoxO signaling pathway_Homo sapiens_hsa040680.44803519
124Platelet activation_Homo sapiens_hsa046110.44554678
125Cocaine addiction_Homo sapiens_hsa050300.43626431
126Proteoglycans in cancer_Homo sapiens_hsa052050.42415015
127Glioma_Homo sapiens_hsa052140.41688697
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36834024
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36376045
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.33860065
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.32043832
132HIF-1 signaling pathway_Homo sapiens_hsa040660.31463707
133Endometrial cancer_Homo sapiens_hsa052130.30887475
134Thyroid cancer_Homo sapiens_hsa052160.28079940
135Non-small cell lung cancer_Homo sapiens_hsa052230.27987475
136Inositol phosphate metabolism_Homo sapiens_hsa005620.26340724
137MAPK signaling pathway_Homo sapiens_hsa040100.26325400

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