DCAF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.84966127
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47825693
3L-phenylalanine catabolic process (GO:0006559)4.47825693
4lysine metabolic process (GO:0006553)4.22797067
5lysine catabolic process (GO:0006554)4.22797067
6carnitine shuttle (GO:0006853)4.17209928
7mannose metabolic process (GO:0006013)4.11809693
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.07889394
9L-phenylalanine metabolic process (GO:0006558)4.07889394
10fatty acid transmembrane transport (GO:1902001)3.97037170
11alpha-linolenic acid metabolic process (GO:0036109)3.89837392
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.87217304
13aromatic amino acid family catabolic process (GO:0009074)3.75993406
14fatty acid beta-oxidation (GO:0006635)3.74931029
15short-chain fatty acid metabolic process (GO:0046459)3.61156634
16valine metabolic process (GO:0006573)3.55380123
17biotin metabolic process (GO:0006768)3.51854964
18fatty acid oxidation (GO:0019395)3.49225420
19kynurenine metabolic process (GO:0070189)3.47115995
20lipid oxidation (GO:0034440)3.42039735
21glyoxylate metabolic process (GO:0046487)3.39917789
22aspartate family amino acid catabolic process (GO:0009068)3.37798103
232-oxoglutarate metabolic process (GO:0006103)3.35824579
24regulation of gamma-delta T cell differentiation (GO:0045586)3.35673760
25histone H3-K36 demethylation (GO:0070544)3.34490993
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.34459114
27fatty acid catabolic process (GO:0009062)3.32615211
28acetyl-CoA metabolic process (GO:0006084)3.30923199
29carnitine transmembrane transport (GO:1902603)3.30653666
30regulation of ARF protein signal transduction (GO:0032012)3.30260862
31carnitine transport (GO:0015879)3.30078511
32amino-acid betaine transport (GO:0015838)3.30078511
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29411046
34embryonic retina morphogenesis in camera-type eye (GO:0060059)3.21797579
35indole-containing compound catabolic process (GO:0042436)3.20193334
36indolalkylamine catabolic process (GO:0046218)3.20193334
37tryptophan catabolic process (GO:0006569)3.20193334
38branched-chain amino acid metabolic process (GO:0009081)3.19682448
39amino-acid betaine metabolic process (GO:0006577)3.18081198
40tricarboxylic acid metabolic process (GO:0072350)3.15628528
41positive regulation of gamma-delta T cell activation (GO:0046645)3.14948164
42branched-chain amino acid catabolic process (GO:0009083)3.12187076
43regulation of sequestering of triglyceride (GO:0010889)3.11078968
44positive regulation of Rap GTPase activity (GO:0032854)3.10129662
45bile acid biosynthetic process (GO:0006699)3.09252340
46positive regulation of histone deacetylation (GO:0031065)3.08981218
47tryptophan metabolic process (GO:0006568)3.08593396
48cysteine metabolic process (GO:0006534)3.08096543
49dicarboxylic acid biosynthetic process (GO:0043650)3.05864945
50negative regulation of lipase activity (GO:0060192)3.05003521
51regulation of histone H3-K27 methylation (GO:0061085)3.04889384
52negative regulation of myotube differentiation (GO:0010832)3.02764040
53homocysteine metabolic process (GO:0050667)3.02703772
54monocarboxylic acid catabolic process (GO:0072329)3.02637800
55ethanol oxidation (GO:0006069)3.02155772
56positive regulation of fatty acid oxidation (GO:0046321)3.01690842
57drug transmembrane transport (GO:0006855)2.99332415
58cellular ketone body metabolic process (GO:0046950)2.99006986
59phospholipid homeostasis (GO:0055091)2.98115885
60regulation of gamma-delta T cell activation (GO:0046643)2.94816372
61creatine metabolic process (GO:0006600)2.92322017
62cellular hyperosmotic response (GO:0071474)2.91805658
63quaternary ammonium group transport (GO:0015697)2.90424547
64carnitine metabolic process (GO:0009437)2.89564104
65histone H3-K9 demethylation (GO:0033169)2.88234584
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86732478
67response to mercury ion (GO:0046689)2.85262138
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84337946
69regulation of fatty acid oxidation (GO:0046320)2.84126098
70histone lysine demethylation (GO:0070076)2.81386880
713-UTR-mediated mRNA stabilization (GO:0070935)2.81171498
72sulfur amino acid catabolic process (GO:0000098)2.80493412
73bile acid metabolic process (GO:0008206)2.80413587
74regulation of cholesterol homeostasis (GO:2000188)2.80381980
75acylglycerol homeostasis (GO:0055090)2.77485813
76triglyceride homeostasis (GO:0070328)2.77485813
77regulation of triglyceride catabolic process (GO:0010896)2.77248833
78focal adhesion assembly (GO:0048041)2.76930848
79cell-substrate adherens junction assembly (GO:0007045)2.76930848
80complement activation, alternative pathway (GO:0006957)2.76777444
81cellular modified amino acid catabolic process (GO:0042219)2.76239670
82regulation of fatty acid beta-oxidation (GO:0031998)2.75892404
83alpha-amino acid catabolic process (GO:1901606)2.74054219
84triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73581889
85peptidyl-glutamic acid carboxylation (GO:0017187)2.71917293
86protein carboxylation (GO:0018214)2.71917293
87urea cycle (GO:0000050)2.71232876
88urea metabolic process (GO:0019627)2.71232876
89histone demethylation (GO:0016577)2.70971157
90adherens junction assembly (GO:0034333)2.70013719
91positive thymic T cell selection (GO:0045059)2.69104047
92macroautophagy (GO:0016236)2.68640482
93regulation of skeletal muscle contraction (GO:0014819)2.67621908
94embryonic process involved in female pregnancy (GO:0060136)2.67615231
95regulation of nucleobase-containing compound transport (GO:0032239)2.63030573
96regulation of necroptotic process (GO:0060544)2.62804466
97cellular amino acid catabolic process (GO:0009063)2.60741248
98regulation of protein activation cascade (GO:2000257)2.59770000
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.59196914
100organic acid catabolic process (GO:0016054)2.59005655
101carboxylic acid catabolic process (GO:0046395)2.59005655
102intracellular lipid transport (GO:0032365)2.59004213
103regulation of response to osmotic stress (GO:0047484)2.58682912
104negative regulation of necroptotic process (GO:0060546)2.58162760
105positive regulation of glycolytic process (GO:0045821)2.56823225
106regulation of Rap GTPase activity (GO:0032317)2.56392935
107definitive hemopoiesis (GO:0060216)2.56352093
108fatty acid homeostasis (GO:0055089)2.56063880
109ketone body metabolic process (GO:1902224)2.55043547
110NADH metabolic process (GO:0006734)2.54393196
111thymic T cell selection (GO:0045061)2.53335362
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52838875
113negative regulation of cell killing (GO:0031342)2.52838875
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52045113
115tyrosine metabolic process (GO:0006570)2.51819494
116glutamate metabolic process (GO:0006536)2.51181036
117regulation of bile acid biosynthetic process (GO:0070857)2.50670824
118myofibril assembly (GO:0030239)2.50011593
119regulation of fibrinolysis (GO:0051917)2.49823303
120regulation of cholesterol metabolic process (GO:0090181)2.49436365
121aromatic amino acid family metabolic process (GO:0009072)2.48364195
122regulation of RNA export from nucleus (GO:0046831)2.47401020
123response to laminar fluid shear stress (GO:0034616)2.47181587
124nitrogen cycle metabolic process (GO:0071941)2.47137169
125germinal center formation (GO:0002467)2.46382908
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.45827567
127regulation of ARF GTPase activity (GO:0032312)2.45651648
128negative regulation of fatty acid biosynthetic process (GO:0045717)2.45237793
129response to muramyl dipeptide (GO:0032495)2.44925871
130cardiac myofibril assembly (GO:0055003)2.44440468
131positive regulation of glycogen biosynthetic process (GO:0045725)2.44136360
132regulation of complement activation (GO:0030449)2.43150051
133positive regulation of lipid catabolic process (GO:0050996)2.42309217
134antigen processing and presentation of endogenous antigen (GO:0019883)2.40579351
135negative regulation of cell size (GO:0045792)2.40109589
136histone H4 deacetylation (GO:0070933)2.39218293
137glycogen catabolic process (GO:0005980)2.38698844
138skeletal muscle adaptation (GO:0043501)2.38419691
139drug catabolic process (GO:0042737)2.37684834
140muscle filament sliding (GO:0030049)2.36317759
141actin-myosin filament sliding (GO:0033275)2.36317759
142serine family amino acid catabolic process (GO:0009071)2.36113134
143COPI coating of Golgi vesicle (GO:0048205)2.35661075
144Golgi transport vesicle coating (GO:0048200)2.35661075
145antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33965105
1464-hydroxyproline metabolic process (GO:0019471)2.33883971
147plasma membrane repair (GO:0001778)2.33529025
148urate metabolic process (GO:0046415)2.32487329
149insulin-like growth factor receptor signaling pathway (GO:0048009)2.31867607
150B cell receptor signaling pathway (GO:0050853)2.31649286
151cellular response to epinephrine stimulus (GO:0071872)2.31032472
152negative thymic T cell selection (GO:0045060)2.29696729
153positive regulation of myotube differentiation (GO:0010831)2.28940332
154protein demethylation (GO:0006482)2.28273416
155protein dealkylation (GO:0008214)2.28273416
156retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.27492266
157positive T cell selection (GO:0043368)2.24570248
158positive regulation of granulocyte differentiation (GO:0030854)2.24294450
159oxaloacetate metabolic process (GO:0006107)2.24034491
160positive regulation of triglyceride lipase activity (GO:0061365)2.22433620
161positive regulation of lipoprotein lipase activity (GO:0051006)2.22433620
162phospholipid efflux (GO:0033700)2.22340949
163cellular response to reactive nitrogen species (GO:1902170)2.22255653
164negative regulation of necrotic cell death (GO:0060547)2.22007417
165regulation of fatty acid biosynthetic process (GO:0042304)2.21981854
166regulation of amyloid precursor protein catabolic process (GO:1902991)2.21045556
167cell volume homeostasis (GO:0006884)2.20210024
168epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19391660
169response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.18535490
170cardiac muscle contraction (GO:0060048)2.18422104
171mucosal-associated lymphoid tissue development (GO:0048537)2.18028940
172Peyers patch development (GO:0048541)2.18028940
173T cell selection (GO:0045058)2.16507264
174protein-lipid complex assembly (GO:0065005)2.16258282
175gas transport (GO:0015669)2.15943617
176histone H3 deacetylation (GO:0070932)2.14660661
177negative regulation of fatty acid transport (GO:2000192)2.13496100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.31894313
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.96029231
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.51841675
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.32505951
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.24866771
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.14114017
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.90806888
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.90806685
9MYC_22102868_ChIP-Seq_BL_Human2.80377323
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.56369186
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.52936901
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.51226026
13VDR_21846776_ChIP-Seq_THP-1_Human2.42745166
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.24814205
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07103654
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.00107694
17GATA1_22025678_ChIP-Seq_K562_Human1.99007267
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92361797
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.85397072
20RACK7_27058665_Chip-Seq_MCF-7_Human1.81067727
21* MAF_26560356_Chip-Seq_TH1_Human1.78929497
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77443021
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.76481435
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.71906361
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.71906361
26DROSHA_22980978_ChIP-Seq_HELA_Human1.66483655
27VDR_24763502_ChIP-Seq_THP-1_Human1.65955862
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65189964
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64868742
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.59863200
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59541267
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58160787
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.57267744
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54724455
35* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53456477
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52783901
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50799638
38* UTX_26944678_Chip-Seq_JUKART_Human1.48745273
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47528969
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47521029
41CLOCK_20551151_ChIP-Seq_293T_Human1.47282259
42* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46346641
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46273330
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45655143
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42899368
46CREB1_26743006_Chip-Seq_LNCaP_Human1.42677865
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.42376504
48MAF_26560356_Chip-Seq_TH2_Human1.42118247
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40402875
50SPI1_23127762_ChIP-Seq_K562_Human1.40333859
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.39004632
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38473585
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37224163
54NCOR1_26117541_ChIP-Seq_K562_Human1.36951513
55* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36920450
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36486863
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32033635
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31885593
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.31805282
60* SMC4_20622854_ChIP-Seq_HELA_Human1.30654511
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30580711
62GATA1_19941826_ChIP-Seq_K562_Human1.26311014
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24950221
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23716428
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22799666
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22077171
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21634207
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20246657
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19850380
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.19794914
71SCL_19346495_ChIP-Seq_HPC-7_Human1.19209710
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.17896730
73* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17822487
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17175221
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16639741
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15641345
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.15474548
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.13371733
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.12144116
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11419741
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10336545
82P68_20966046_ChIP-Seq_HELA_Human1.09337502
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08510763
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07725403
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07672041
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07430754
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07115709
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.04130354
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02182581
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01480073
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98594606
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98257476
93* MYB_26560356_Chip-Seq_TH1_Human0.97911674
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97816438
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97146557
96KDM2B_26808549_Chip-Seq_K562_Human0.96852664
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96497483
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96171335
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95915136
100AR_21572438_ChIP-Seq_LNCaP_Human0.95724047
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94857776
102HNF4A_19822575_ChIP-Seq_HepG2_Human0.94645540
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93876015
104GATA2_19941826_ChIP-Seq_K562_Human0.93776043
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92553108
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91783982
107CIITA_25753668_ChIP-Seq_RAJI_Human0.91399808
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90757668
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89736553
110MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88047472
111EZH2_27294783_Chip-Seq_ESCs_Mouse0.87072454
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84856619
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84850602
114KDM2B_26808549_Chip-Seq_DND41_Human0.83480213
115* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83420985
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.83290003
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.82891680
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82459799
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.81614542
120AHR_22903824_ChIP-Seq_MCF-7_Human0.81548421
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80910347
122STAT3_23295773_ChIP-Seq_U87_Human0.78862717
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78736465
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78604079
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78540804
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.77832781
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.77320228
128CTCF_27219007_Chip-Seq_Bcells_Human0.77199382
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76968964
130TCF7_22412390_ChIP-Seq_EML_Mouse0.76050494
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74968004
132LXR_22292898_ChIP-Seq_THP-1_Human0.74949097
133* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74750458
134AR_19668381_ChIP-Seq_PC3_Human0.74221280
135* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74207288
136* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74055953
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73971556
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73858757
139* TP63_22573176_ChIP-Seq_HFKS_Human0.73565438
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.73352632
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72814531
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72661073
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.72626048
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72609890
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72493629
146EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71443359
147RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71443359
148TBL1_22424771_ChIP-Seq_293T_Human0.70976285
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70838373
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.70682573
151SOX2_21211035_ChIP-Seq_LN229_Gbm0.70177293
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69520136
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69269545
154RUNX_20019798_ChIP-Seq_JUKART_Human0.68114580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.82520188
2MP0005365_abnormal_bile_salt3.98398865
3MP0005360_urolithiasis3.91914425
4MP0005085_abnormal_gallbladder_physiolo3.70951114
5MP0003252_abnormal_bile_duct3.44565130
6MP0002837_dystrophic_cardiac_calcinosis3.20707993
7MP0005670_abnormal_white_adipose2.93919790
8MP0003656_abnormal_erythrocyte_physiolo2.79154475
9MP0000751_myopathy2.66020154
10MP0004130_abnormal_muscle_cell2.57089884
11MP0002009_preneoplasia2.54637625
12MP0005666_abnormal_adipose_tissue2.51150615
13MP0004145_abnormal_muscle_electrophysio2.39692202
14MP0008875_abnormal_xenobiotic_pharmacok2.37048687
15MP0005083_abnormal_biliary_tract2.36918114
16MP0010329_abnormal_lipoprotein_level2.23627571
17MP0008260_abnormal_autophagy2.20730286
18MP0004185_abnormal_adipocyte_glucose2.18912522
19MP0003646_muscle_fatigue2.16908461
20MP0003690_abnormal_glial_cell2.14553307
21MP0003172_abnormal_lysosome_physiology2.13507747
22MP0003195_calcinosis2.08056050
23MP0003763_abnormal_thymus_physiology2.02473319
24MP0002396_abnormal_hematopoietic_system2.01630487
25MP0004043_abnormal_pH_regulation1.98889024
26MP0005375_adipose_tissue_phenotype1.95837923
27MP0009278_abnormal_bone_marrow1.93281260
28MP0004036_abnormal_muscle_relaxation1.92391200
29MP0000749_muscle_degeneration1.86311524
30MP0003303_peritoneal_inflammation1.78084702
31MP0005076_abnormal_cell_differentiation1.77434687
32MP0005332_abnormal_amino_acid1.76672541
33MP0002118_abnormal_lipid_homeostasis1.75279727
34MP0000747_muscle_weakness1.74451636
35MP0001666_abnormal_nutrient_absorption1.72227509
36MP0005409_darkened_coat_color1.67139056
37MP0003436_decreased_susceptibility_to1.64674051
38MP0003329_amyloid_beta_deposits1.63092400
39MP0008961_abnormal_basal_metabolism1.61434455
40MP0002269_muscular_atrophy1.59850862
41MP0000003_abnormal_adipose_tissue1.58507336
42MP0004087_abnormal_muscle_fiber1.55829865
43MP0009780_abnormal_chondrocyte_physiolo1.54801189
44MP0003191_abnormal_cellular_cholesterol1.54406889
45MP0002971_abnormal_brown_adipose1.54117923
46MP0003091_abnormal_cell_migration1.52743585
47MP0010368_abnormal_lymphatic_system1.50035058
48MP0005451_abnormal_body_composition1.48746398
49MP0005330_cardiomyopathy1.47424809
50MP0003868_abnormal_feces_composition1.47253871
51MP0000609_abnormal_liver_physiology1.42984684
52MP0002138_abnormal_hepatobiliary_system1.42446339
53MP0004215_abnormal_myocardial_fiber1.41577608
54MP0002078_abnormal_glucose_homeostasis1.40728059
55MP0009643_abnormal_urine_homeostasis1.37894815
56MP0003566_abnormal_cell_adhesion1.37632054
57MP0005620_abnormal_muscle_contractility1.37231444
58MP0005220_abnormal_exocrine_pancreas1.36739034
59MP0003828_pulmonary_edema1.35710789
60MP0004084_abnormal_cardiac_muscle1.33557104
61MP0004381_abnormal_hair_follicle1.33120211
62MP0001545_abnormal_hematopoietic_system1.31814453
63MP0005397_hematopoietic_system_phenotyp1.31814453
64MP0003283_abnormal_digestive_organ1.31673212
65MP0002106_abnormal_muscle_physiology1.31608185
66MP0003300_gastrointestinal_ulcer1.27413325
67MP0004859_abnormal_synaptic_plasticity1.26141208
68MP0004019_abnormal_vitamin_homeostasis1.25249909
69MP0001765_abnormal_ion_homeostasis1.25048631
70MP0000759_abnormal_skeletal_muscle1.23804659
71MP0001661_extended_life_span1.22737192
72MP0002166_altered_tumor_susceptibility1.22566923
73MP0004808_abnormal_hematopoietic_stem1.22342334
74MP0009840_abnormal_foam_cell1.21071081
75MP0004947_skin_inflammation1.20790547
76MP0003045_fibrosis1.20304593
77MP0001851_eye_inflammation1.17265044
78MP0002928_abnormal_bile_duct1.17082616
79MP0000013_abnormal_adipose_tissue1.14357025
80MP0005369_muscle_phenotype1.14203419
81MP0001944_abnormal_pancreas_morphology1.10474465
82MP0004858_abnormal_nervous_system1.10218430
83MP0010630_abnormal_cardiac_muscle1.09529250
84MP0005334_abnormal_fat_pad1.05823599
85MP0008438_abnormal_cutaneous_collagen1.03989093
86MP0003705_abnormal_hypodermis_morpholog1.02743069
87MP0005319_abnormal_enzyme/_coenzyme1.01878229
88MP0008569_lethality_at_weaning1.01103521
89MP0005464_abnormal_platelet_physiology1.00837371
90MP0000604_amyloidosis1.00198500
91MP0009384_cardiac_valve_regurgitation0.99883342
92MP0009115_abnormal_fat_cell0.99271882
93MP0003806_abnormal_nucleotide_metabolis0.97172236
94MP0000462_abnormal_digestive_system0.97026869
95MP0005647_abnormal_sex_gland0.95734372
96MP0001849_ear_inflammation0.95602505
97MP0003279_aneurysm0.95300148
98MP0002108_abnormal_muscle_morphology0.95119944
99MP0000383_abnormal_hair_follicle0.93434373
100MP0000703_abnormal_thymus_morphology0.93227275
101MP0004264_abnormal_extraembryonic_tissu0.92981043
102MP0004510_myositis0.92627979
103MP0002132_abnormal_respiratory_system0.92169358
104MP0000685_abnormal_immune_system0.91236345
105MP0002168_other_aberrant_phenotype0.89756897
106MP0002398_abnormal_bone_marrow0.89476744
107MP0010678_abnormal_skin_adnexa0.89382975
108MP0000569_abnormal_digit_pigmentation0.89231634
109MP0004233_abnormal_muscle_weight0.87800639
110MP0001915_intracranial_hemorrhage0.87406882
111MP0001270_distended_abdomen0.86904868
112MP0005584_abnormal_enzyme/coenzyme_acti0.86305985
113MP0003453_abnormal_keratinocyte_physiol0.85777488
114MP0002933_joint_inflammation0.83808737
115MP0000920_abnormal_myelination0.83247292
116MP0002419_abnormal_innate_immunity0.83232526
117MP0006138_congestive_heart_failure0.82259256
118MP0002693_abnormal_pancreas_physiology0.82213192
119MP0002972_abnormal_cardiac_muscle0.82170974
120MP0003137_abnormal_impulse_conducting0.81456927
121MP0005058_abnormal_lysosome_morphology0.81252068
122MP0000579_abnormal_nail_morphology0.81129454
123MP0006054_spinal_hemorrhage0.80656764
124MP0003221_abnormal_cardiomyocyte_apopto0.80538954
125MP0001873_stomach_inflammation0.79329153
126MP0003959_abnormal_lean_body0.79055057
127MP0002332_abnormal_exercise_endurance0.78952501
128MP0002234_abnormal_pharynx_morphology0.78317149
129MP0003950_abnormal_plasma_membrane0.77052156
130MP0005621_abnormal_cell_physiology0.76773813
131MP0008775_abnormal_heart_ventricle0.76592912
132MP0001544_abnormal_cardiovascular_syste0.76235854
133MP0005385_cardiovascular_system_phenoty0.76235854
134MP0002998_abnormal_bone_remodeling0.72971364
135MP0004085_abnormal_heartbeat0.72555987
136MP0002405_respiratory_system_inflammati0.72317095
137MP0001835_abnormal_antigen_presentation0.72060643
138MP0009672_abnormal_birth_weight0.71911805
139MP0005025_abnormal_response_to0.71111229
140MP0002722_abnormal_immune_system0.70515971
141MP0002970_abnormal_white_adipose0.70230292
142MP0004484_altered_response_of0.69945607
143MP0000230_abnormal_systemic_arterial0.69811539
144MP0003953_abnormal_hormone_level0.69119997
145MP0005636_abnormal_mineral_homeostasis0.68871906
146MP0000733_abnormal_muscle_development0.68427541
147MP0003011_delayed_dark_adaptation0.68252677
148MP0001756_abnormal_urination0.68180949
149MP0002896_abnormal_bone_mineralization0.67218441
150MP0005535_abnormal_body_temperature0.65517156
151MP0001958_emphysema0.63925570
152MP0000750_abnormal_muscle_regeneration0.63754562
153MP0009642_abnormal_blood_homeostasis0.63418376

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.77963588
2Exercise-induced myalgia (HP:0003738)4.38814755
3Ketosis (HP:0001946)4.26319998
4Ketoacidosis (HP:0001993)4.19053318
5Deep venous thrombosis (HP:0002625)4.15471827
6Intrahepatic cholestasis (HP:0001406)3.92375888
7Myoglobinuria (HP:0002913)3.86779914
8Hyperinsulinemic hypoglycemia (HP:0000825)3.79743040
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.73364601
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48382820
11Hyporeflexia of lower limbs (HP:0002600)3.30026137
12Difficulty running (HP:0009046)3.26001777
13Type 1 muscle fiber predominance (HP:0003803)3.23748180
14Xanthomatosis (HP:0000991)3.21585957
15Hypoglycemic seizures (HP:0002173)3.18656602
16Exercise-induced muscle cramps (HP:0003710)3.05026846
17Hyperkalemia (HP:0002153)3.02754419
18Hyperglycinuria (HP:0003108)3.01961935
19Abnormality of skeletal muscle fiber size (HP:0012084)3.01080344
20Hyperammonemia (HP:0001987)2.99118405
21Calf muscle hypertrophy (HP:0008981)2.97358107
22Muscle hypertrophy of the lower extremities (HP:0008968)2.96935044
23Renal cortical cysts (HP:0000803)2.96876651
24Abnormality of serine family amino acid metabolism (HP:0010894)2.95263185
25Abnormality of glycine metabolism (HP:0010895)2.95263185
26Broad metatarsal (HP:0001783)2.92951217
27Obstructive sleep apnea (HP:0002870)2.91969957
28Muscle fiber splitting (HP:0003555)2.90007549
29Myopathic facies (HP:0002058)2.84349350
30Hypoalphalipoproteinemia (HP:0003233)2.78936357
31Gout (HP:0001997)2.78521616
32Hyperglycemia (HP:0003074)2.78509831
33Prolonged partial thromboplastin time (HP:0003645)2.76556465
34Generalized aminoaciduria (HP:0002909)2.66673797
35Insulin-resistant diabetes mellitus (HP:0000831)2.65892571
36Sudden death (HP:0001699)2.65141941
37Abnormality of fatty-acid metabolism (HP:0004359)2.64941242
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59787251
39Colitis (HP:0002583)2.59570282
40Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.59207003
41Complement deficiency (HP:0004431)2.56398186
42Hyperlipoproteinemia (HP:0010980)2.55955161
43Asymmetric septal hypertrophy (HP:0001670)2.54553831
44Eczematoid dermatitis (HP:0000976)2.53949294
45Muscle fiber inclusion bodies (HP:0100299)2.52884345
46Bundle branch block (HP:0011710)2.52018769
47Abnormality of the left ventricular outflow tract (HP:0011103)2.51680552
48Subaortic stenosis (HP:0001682)2.51680552
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48116501
50Dicarboxylic aciduria (HP:0003215)2.48116501
51Abnormality of purine metabolism (HP:0004352)2.45906302
52Cerebral aneurysm (HP:0004944)2.45531409
53Pancreatic islet-cell hyperplasia (HP:0004510)2.43186916
54Rhabdomyolysis (HP:0003201)2.41533387
55Ventricular tachycardia (HP:0004756)2.40059693
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37607068
57Dysmetric saccades (HP:0000641)2.37228479
58Polycythemia (HP:0001901)2.37033439
59Distal lower limb amyotrophy (HP:0008944)2.36943938
60Symptomatic seizures (HP:0011145)2.36555954
61Abnormality of endocrine pancreas physiology (HP:0012093)2.34734885
62Abnormality of the pancreatic islet cells (HP:0006476)2.34734885
63Hypoplastic ischia (HP:0003175)2.33275979
64Reticulocytosis (HP:0001923)2.33207284
65Late onset (HP:0003584)2.32162169
66Epidermoid cyst (HP:0200040)2.29961383
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27362988
68Hyperglycinemia (HP:0002154)2.25736073
69Distal lower limb muscle weakness (HP:0009053)2.24584143
70Abnormality of the calf musculature (HP:0001430)2.23885421
71Increased connective tissue (HP:0009025)2.23852863
72Abnormality of complement system (HP:0005339)2.23576518
73Abnormality of the common coagulation pathway (HP:0010990)2.19722554
74Hyperuricemia (HP:0002149)2.19094196
75Increased purine levels (HP:0004368)2.19094196
76Abnormality of the ischium (HP:0003174)2.18781268
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.18062190
78Round ear (HP:0100830)2.16352685
79Large for gestational age (HP:0001520)2.14427496
80Joint hemorrhage (HP:0005261)2.14093035
81Right ventricular cardiomyopathy (HP:0011663)2.11251238
82Metabolic acidosis (HP:0001942)2.09602464
83Conjugated hyperbilirubinemia (HP:0002908)2.07404138
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07307646
85Cellulitis (HP:0100658)2.07189176
86Abnormality of potassium homeostasis (HP:0011042)2.06224965
87Bowel incontinence (HP:0002607)2.05809737
88Elfin facies (HP:0004428)2.05764176
89Fatigue (HP:0012378)2.05084628
90Enlarged kidneys (HP:0000105)2.03472107
91Hemorrhage of the eye (HP:0011885)2.03053761
92Hypolipoproteinemia (HP:0010981)2.02830932
93Abnormality of methionine metabolism (HP:0010901)2.00428734
94Heart block (HP:0012722)1.99773652
95Increased IgE level (HP:0003212)1.99731079
96Ulnar deviation of the wrist (HP:0003049)1.96507023
97Germ cell neoplasia (HP:0100728)1.96291829
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96265874
99Abnormality of the intrinsic pathway (HP:0010989)1.96245410
100Ankle clonus (HP:0011448)1.96096010
101Foot dorsiflexor weakness (HP:0009027)1.96063299
102Prolonged QT interval (HP:0001657)1.95571274
103Aneurysm (HP:0002617)1.95305833
104Muscle stiffness (HP:0003552)1.93135503
105Papilledema (HP:0001085)1.92946874
106Metaphyseal cupping (HP:0003021)1.92421892
107Abnormal gallbladder morphology (HP:0012437)1.92419684
108Spontaneous hematomas (HP:0007420)1.92267920
109Dilated cardiomyopathy (HP:0001644)1.92182677
110Abnormality of the fingertips (HP:0001211)1.92017625
111Abnormality of nucleobase metabolism (HP:0010932)1.91841115
112Cholelithiasis (HP:0001081)1.91535084
113Hyperbilirubinemia (HP:0002904)1.91360415
114Hyperacusis (HP:0010780)1.91304093
115Abnormality of the foot musculature (HP:0001436)1.89492558
116Renovascular hypertension (HP:0100817)1.88858455
117Insulin resistance (HP:0000855)1.88355466
118Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87963716
119Interstitial pulmonary disease (HP:0006530)1.85566174
120Increased variability in muscle fiber diameter (HP:0003557)1.84670039
121Neck muscle weakness (HP:0000467)1.83866407
122Skin nodule (HP:0200036)1.83774471
123Turricephaly (HP:0000262)1.82895531
124Hypokalemia (HP:0002900)1.82594912
125Distal arthrogryposis (HP:0005684)1.82565677
126Nemaline bodies (HP:0003798)1.82393542
127Flat acetabular roof (HP:0003180)1.81903568
128Cerebral inclusion bodies (HP:0100314)1.81424152
129Abnormal large intestine physiology (HP:0012700)1.80378557
130EMG: myopathic abnormalities (HP:0003458)1.79731313
131Gastrointestinal inflammation (HP:0004386)1.78833794
132Back pain (HP:0003418)1.78356967
133Ankyloglossia (HP:0010296)1.78007288
134Proximal tubulopathy (HP:0000114)1.76776686
135Slow saccadic eye movements (HP:0000514)1.76375660
136Atrial fibrillation (HP:0005110)1.75772600
137Atrioventricular block (HP:0001678)1.75413755
138Protrusio acetabuli (HP:0003179)1.74374767
139Seborrheic dermatitis (HP:0001051)1.73995052
140Abnormality of the calcaneus (HP:0008364)1.73744862
141Neonatal hypoglycemia (HP:0001998)1.73723373
142* EMG: neuropathic changes (HP:0003445)1.72610383
143Mildly elevated creatine phosphokinase (HP:0008180)1.72409265
144Lower limb amyotrophy (HP:0007210)1.72268026
145Vertebral compression fractures (HP:0002953)1.71939396
146Broad face (HP:0000283)1.69205881
147Inflammation of the large intestine (HP:0002037)1.67973707
148Vertebral arch anomaly (HP:0008438)1.67791042
149Systemic lupus erythematosus (HP:0002725)1.66610555
150Neurofibrillary tangles (HP:0002185)1.64728999
151Abnormal gallbladder physiology (HP:0012438)1.63824038
152Cholecystitis (HP:0001082)1.63824038
153Recurrent gram-negative bacterial infections (HP:0005420)1.61990663
154Abnormality of the thoracic spine (HP:0100711)1.60898544
155Arterial tortuosity (HP:0005116)1.58570926
156Prolonged bleeding time (HP:0003010)1.57904008
157Gingivitis (HP:0000230)1.57874647
158Macroorchidism (HP:0000053)1.57577356
159Stridor (HP:0010307)1.57038827
160Glomerulonephritis (HP:0000099)1.56717078
161Visceral angiomatosis (HP:0100761)1.55750376
162Aortic aneurysm (HP:0004942)1.55040078
163Heterotopia (HP:0002282)1.54858934
164Peripheral hypomyelination (HP:0007182)1.54848831
165Gingival bleeding (HP:0000225)1.54385378
166Poikilocytosis (HP:0004447)1.53702814
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53292163
168Frequent falls (HP:0002359)1.53273654
169Epistaxis (HP:0000421)1.51884958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.48291793
2SIK13.24602129
3INSRR3.22606333
4TRIB33.20113499
5EEF2K2.80742556
6TTN2.61356036
7BCKDK2.52951136
8PKN22.42041878
9TAOK32.36277589
10LATS12.30849348
11EPHB12.15375588
12CAMK1D2.14335227
13OBSCN2.04397833
14CAMK1G2.01264112
15FLT31.83824326
16FGFR41.81542748
17PHKG11.78975142
18PHKG21.78975142
19PTK61.68968117
20MAP3K71.64199262
21RIPK11.63883745
22RIPK41.63553488
23PIK3CG1.57595933
24DMPK1.56575032
25KSR21.45816598
26SMG11.45174090
27TYK21.43364608
28LMTK21.39470689
29MAPK151.34778169
30PRKAA21.33690434
31ERN11.32909791
32WNK41.31987868
33HIPK21.31644458
34MAP4K11.30019503
35ZAP701.29329803
36TIE11.28457836
37PDGFRA1.27986131
38MAP3K101.22273997
39PRKD21.14818579
40PRKD31.13907086
41PINK11.12480253
42FGFR21.10976800
43MAP2K31.09717611
44MAPK111.09381778
45WNK11.08979396
46EPHA31.05514165
47PRKCH1.05208973
48MAP3K61.04155145
49RET1.01133434
50PRKAA10.98945384
51TNK20.98472960
52FES0.97627140
53TGFBR20.95537395
54PRKD10.95529717
55SGK30.91434538
56MAPK70.90983408
57MARK20.85100869
58MAP3K140.84782164
59ICK0.80982178
60JAK10.79722595
61BLK0.79640313
62CDC42BPA0.77895321
63BTK0.77668770
64UHMK10.75304305
65PASK0.74696577
66CAMKK10.74386024
67MAP2K40.72853190
68STK390.71783712
69MAPKAPK30.71268151
70NLK0.70749841
71BRD40.70441156
72MAP2K20.70343955
73CDK60.70252520
74HCK0.69942396
75MTOR0.69851258
76MAP3K130.69352501
77NTRK10.68631077
78MAPK120.68509131
79TYRO30.68026810
80AKT30.67618125
81PIK3CA0.67152783
82SIK20.65217184
83TBK10.65040082
84MAPK100.65011419
85SGK20.64764329
86GRK10.64606542
87SGK4940.64537451
88SGK2230.64537451
89MAP3K20.63611750
90JAK20.62378022
91PTK20.61811138
92BMX0.60774346
93STK30.59363597
94GRK60.59038388
95RPS6KC10.58688989
96RPS6KL10.58688989
97NEK60.57792351
98NTRK30.57025399
99PAK30.56830331
100PDGFRB0.56244375
101TRPM70.55628266
102PAK60.54706443
103MAPKAPK50.54644997
104NEK90.54496283
105CDK90.54052823
106PKN10.53549361
107CDK40.52734758
108CAMK40.52349075
109STK380.52154137
110KIT0.52069436
111PDPK10.51880856
112SYK0.51696304
113MUSK0.50651836
114OXSR10.49906992
115SIK30.49789204
116MAP3K10.48988183
117FGFR30.46264245
118PDK10.45700206
119DYRK1B0.45628498
120MAPK30.44833789
121CSK0.43970639
122LRRK20.43074021
123SGK10.42247653
124MET0.41935144
125DAPK20.41802302
126ERBB20.39233924
127PAK20.39058418
128IRAK20.38861631
129CDK120.37059878
130ERBB40.36919018
131RPS6KA20.36740660
132ITK0.35044627
133NUAK10.34444438
134JAK30.34215150
135GSK3A0.33776490
136ROCK10.31827140
137TAOK10.31826449
138DYRK30.31399626

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.18488133
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.02621613
3Fatty acid degradation_Homo sapiens_hsa000713.00236135
4Propanoate metabolism_Homo sapiens_hsa006402.82042425
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.69067837
6Tryptophan metabolism_Homo sapiens_hsa003802.49775095
7Fatty acid metabolism_Homo sapiens_hsa012122.39208277
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.33049953
9Butanoate metabolism_Homo sapiens_hsa006502.32149458
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13721843
11Lysine degradation_Homo sapiens_hsa003102.13092368
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01236136
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96393320
14PPAR signaling pathway_Homo sapiens_hsa033201.96287854
15Acute myeloid leukemia_Homo sapiens_hsa052211.84117588
16Arginine biosynthesis_Homo sapiens_hsa002201.80990025
17beta-Alanine metabolism_Homo sapiens_hsa004101.74186981
18ABC transporters_Homo sapiens_hsa020101.72739099
19Chronic myeloid leukemia_Homo sapiens_hsa052201.67377979
20Peroxisome_Homo sapiens_hsa041461.60887487
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58836768
22Caffeine metabolism_Homo sapiens_hsa002321.58573771
23B cell receptor signaling pathway_Homo sapiens_hsa046621.55790090
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53666441
25Complement and coagulation cascades_Homo sapiens_hsa046101.52634902
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51321973
27Fatty acid elongation_Homo sapiens_hsa000621.51111363
28VEGF signaling pathway_Homo sapiens_hsa043701.41585958
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40647981
30Bile secretion_Homo sapiens_hsa049761.40598680
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39292655
32mTOR signaling pathway_Homo sapiens_hsa041501.38408934
33Pyruvate metabolism_Homo sapiens_hsa006201.37812742
34Endometrial cancer_Homo sapiens_hsa052131.36411762
35Starch and sucrose metabolism_Homo sapiens_hsa005001.34740905
36Pancreatic cancer_Homo sapiens_hsa052121.32747344
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31556575
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26716746
39Choline metabolism in cancer_Homo sapiens_hsa052311.25969056
40Insulin resistance_Homo sapiens_hsa049311.24923496
41Long-term potentiation_Homo sapiens_hsa047201.23707791
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23097067
43Renal cell carcinoma_Homo sapiens_hsa052111.22239226
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20513835
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.19676705
46Histidine metabolism_Homo sapiens_hsa003401.17704552
47Glioma_Homo sapiens_hsa052141.15847706
48Fatty acid biosynthesis_Homo sapiens_hsa000611.15128722
49GnRH signaling pathway_Homo sapiens_hsa049121.11925421
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.11531058
51Selenocompound metabolism_Homo sapiens_hsa004501.10416170
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09147436
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06426271
54ErbB signaling pathway_Homo sapiens_hsa040121.04462187
55Osteoclast differentiation_Homo sapiens_hsa043801.03685587
56Glucagon signaling pathway_Homo sapiens_hsa049221.02940983
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02242182
58Prion diseases_Homo sapiens_hsa050201.00286761
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98747923
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96650492
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.95979660
62Circadian rhythm_Homo sapiens_hsa047100.95979612
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.95585765
64AMPK signaling pathway_Homo sapiens_hsa041520.93921755
65Glycerolipid metabolism_Homo sapiens_hsa005610.93876959
66T cell receptor signaling pathway_Homo sapiens_hsa046600.93589473
67Sulfur metabolism_Homo sapiens_hsa009200.92917490
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.92571065
69Thyroid cancer_Homo sapiens_hsa052160.92437503
70Estrogen signaling pathway_Homo sapiens_hsa049150.92162671
71Type II diabetes mellitus_Homo sapiens_hsa049300.90660430
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.90023629
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88651666
74Ovarian steroidogenesis_Homo sapiens_hsa049130.88040361
75Colorectal cancer_Homo sapiens_hsa052100.87430779
76Carbon metabolism_Homo sapiens_hsa012000.86885576
77Dilated cardiomyopathy_Homo sapiens_hsa054140.85049188
78Hepatitis C_Homo sapiens_hsa051600.84387494
79Prostate cancer_Homo sapiens_hsa052150.83978874
80Platelet activation_Homo sapiens_hsa046110.83206658
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80376412
82Phenylalanine metabolism_Homo sapiens_hsa003600.80162215
83Fructose and mannose metabolism_Homo sapiens_hsa000510.75923136
84HIF-1 signaling pathway_Homo sapiens_hsa040660.74708184
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74528056
86Arginine and proline metabolism_Homo sapiens_hsa003300.73778709
87Chemical carcinogenesis_Homo sapiens_hsa052040.73191032
88Retinol metabolism_Homo sapiens_hsa008300.73172175
89Amoebiasis_Homo sapiens_hsa051460.73144096
90Insulin secretion_Homo sapiens_hsa049110.72075313
91Tyrosine metabolism_Homo sapiens_hsa003500.72029401
92Fat digestion and absorption_Homo sapiens_hsa049750.70458738
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69828132
94Hepatitis B_Homo sapiens_hsa051610.68830098
95Toxoplasmosis_Homo sapiens_hsa051450.68463905
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68445804
97Insulin signaling pathway_Homo sapiens_hsa049100.68125002
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65921947
99Leishmaniasis_Homo sapiens_hsa051400.65869437
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64387864
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.63910003
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61925845
103Pentose phosphate pathway_Homo sapiens_hsa000300.60208574
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59807845
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59123869
106Oxytocin signaling pathway_Homo sapiens_hsa049210.58556667
107Renin secretion_Homo sapiens_hsa049240.58506877
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57746898
109Adherens junction_Homo sapiens_hsa045200.57275817
110Influenza A_Homo sapiens_hsa051640.56915408
111Small cell lung cancer_Homo sapiens_hsa052220.55735794
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.55573446
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54681637
114Protein digestion and absorption_Homo sapiens_hsa049740.54516905
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53699564
116Biosynthesis of amino acids_Homo sapiens_hsa012300.52972691
117Staphylococcus aureus infection_Homo sapiens_hsa051500.52458503
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52032524
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52015226
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50272998
121MAPK signaling pathway_Homo sapiens_hsa040100.50242782
122Endocytosis_Homo sapiens_hsa041440.48610494
123TNF signaling pathway_Homo sapiens_hsa046680.48085030
124Proteoglycans in cancer_Homo sapiens_hsa052050.47934627
125Dorso-ventral axis formation_Homo sapiens_hsa043200.47010958
126Vitamin B6 metabolism_Homo sapiens_hsa007500.45276962
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45261288
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43618844
129Vitamin digestion and absorption_Homo sapiens_hsa049770.40976459
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38341079
131Notch signaling pathway_Homo sapiens_hsa043300.37711322
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35123575
133Focal adhesion_Homo sapiens_hsa045100.35005631
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.34254730
135Pancreatic secretion_Homo sapiens_hsa049720.34097972
136Linoleic acid metabolism_Homo sapiens_hsa005910.32566972
137Inositol phosphate metabolism_Homo sapiens_hsa005620.32153047
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.32118638
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.32110764
140cAMP signaling pathway_Homo sapiens_hsa040240.31821254
141ECM-receptor interaction_Homo sapiens_hsa045120.31487649
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28762035
143Thyroid hormone synthesis_Homo sapiens_hsa049180.28446856
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26967789
145Other glycan degradation_Homo sapiens_hsa005110.26624247
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.25916163
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.25639652
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25348481
149Non-small cell lung cancer_Homo sapiens_hsa052230.22558270
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22444614
151FoxO signaling pathway_Homo sapiens_hsa040680.22389803
152Prolactin signaling pathway_Homo sapiens_hsa049170.21198650
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.18721974

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