ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.66797161
2	androgen biosynthetic process (GO:0006702)	8.43128072
3	positive regulation of catecholamine secretion (GO:0033605)	8.38527857
4	regulation of oxidative stress-induced neuron death (GO:1903203)	8.05885501
5	synapsis (GO:0007129)	7.86413470
6	regulation of phosphoprotein phosphatase activity (GO:0043666)	7.54058380
7	organic cation transport (GO:0015695)	7.37719011
8	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	7.08985310
9	spermatid development (GO:0007286)	6.87627012
10	binding of sperm to zona pellucida (GO:0007339)	6.61578554
11	chromosome organization involved in meiosis (GO:0070192)	6.50030026
12	acrosome reaction (GO:0007340)	6.47240085
13	glucocorticoid biosynthetic process (GO:0006704)	6.39148135
14	regulation of oxidative phosphorylation (GO:0002082)	6.36389951
15	relaxation of smooth muscle (GO:0044557)	5.92749788
16	sperm motility (GO:0030317)	5.81570981
17	multicellular organism reproduction (GO:0032504)	5.56860178
18	motile cilium assembly (GO:0044458)	5.50203155
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.39052636
20	meiotic nuclear division (GO:0007126)	5.24556351
21	piRNA metabolic process (GO:0034587)	5.20833537
22	synaptonemal complex assembly (GO:0007130)	5.10076176
23	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.06136484
24	sperm-egg recognition (GO:0035036)	5.02557385
25	potassium ion export (GO:0071435)	4.91191963
26	male sex determination (GO:0030238)	4.75983645
27	glucocorticoid metabolic process (GO:0008211)	4.67997825
28	synaptonemal complex organization (GO:0070193)	4.65883967
29	polyamine biosynthetic process (GO:0006596)	4.52700408
30	male meiosis I (GO:0007141)	4.49820988
31	DNA strand renaturation (GO:0000733)	4.35408355
32	cell-cell recognition (GO:0009988)	4.34499708
33	Leydig cell differentiation (GO:0033327)	4.34247348
34	androgen metabolic process (GO:0008209)	4.33248814
35	positive regulation of glycolytic process (GO:0045821)	4.33156793
36	amyloid precursor protein catabolic process (GO:0042987)	4.31161620
37	coenzyme catabolic process (GO:0009109)	4.23355039
38	cellular response to toxic substance (GO:0097237)	4.20961520
39	glycogen metabolic process (GO:0005977)	4.17075551
40	male genitalia development (GO:0030539)	4.17053834
41	regulation of hydrogen peroxide-induced cell death (GO:1903205)	4.16503930
42	hemoglobin metabolic process (GO:0020027)	4.15040807
43	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.14786608
44	aspartate family amino acid catabolic process (GO:0009068)	4.14532841
45	low-density lipoprotein particle clearance (GO:0034383)	4.13853240
46	glucan metabolic process (GO:0044042)	4.13579804
47	cellular glucan metabolic process (GO:0006073)	4.13579804
48	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	4.09650401
49	nucleosome disassembly (GO:0006337)	4.06096598
50	protein-DNA complex disassembly (GO:0032986)	4.06096598
51	cGMP-mediated signaling (GO:0019934)	4.05159619
52	cilium or flagellum-dependent cell motility (GO:0001539)	4.04853413
53	hormone biosynthetic process (GO:0042446)	4.03774748
54	germ cell development (GO:0007281)	4.03378224
55	membrane repolarization during action potential (GO:0086011)	4.01233578
56	negative regulation of macrophage differentiation (GO:0045650)	3.91960891
57	histone exchange (GO:0043486)	3.89679783
58	activation of protein kinase B activity (GO:0032148)	3.84113814
59	adhesion of symbiont to host (GO:0044406)	3.79843899
60	reproduction (GO:0000003)	3.77983893
61	oogenesis (GO:0048477)	3.76057593
62	reproductive system development (GO:0061458)	3.74106915
63	axonemal dynein complex assembly (GO:0070286)	3.71993758
64	negative regulation of response to reactive oxygen species (GO:1901032)	3.71080127
65	C21-steroid hormone biosynthetic process (GO:0006700)	3.70657622
66	positive regulation of male gonad development (GO:2000020)	3.69111326
67	regulation of dopamine secretion (GO:0014059)	3.67436401
68	meiotic chromosome segregation (GO:0045132)	3.67427375
69	indole-containing compound catabolic process (GO:0042436)	3.64654194
70	indolalkylamine catabolic process (GO:0046218)	3.64654194
71	tryptophan catabolic process (GO:0006569)	3.64654194
72	epithelial cilium movement (GO:0003351)	3.61134651
73	meiosis I (GO:0007127)	3.60707994
74	chaperone-mediated protein transport (GO:0072321)	3.60489362
75	tryptophan metabolic process (GO:0006568)	3.56884317
76	TOR signaling (GO:0031929)	3.54136586
77	glutathione derivative biosynthetic process (GO:1901687)	3.51519764
78	glutathione derivative metabolic process (GO:1901685)	3.51519764
79	DNA double-strand break processing (GO:0000729)	3.45014278
80	estrogen biosynthetic process (GO:0006703)	3.43236623
81	mitochondrion degradation (GO:0000422)	3.40630324
82	protein polymerization (GO:0051258)	3.37493148
83	single fertilization (GO:0007338)	3.35298620
84	inner mitochondrial membrane organization (GO:0007007)	3.34988232
85	histone H3-K36 demethylation (GO:0070544)	3.33011881
86	response to acidic pH (GO:0010447)	3.29651491
87	ventricular system development (GO:0021591)	3.24288672
88	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.22026459
89	acrosome assembly (GO:0001675)	3.21279787
90	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.20820342
91	DNA methylation involved in gamete generation (GO:0043046)	3.20585949
92	response to muscle activity (GO:0014850)	3.20036962
93	sex determination (GO:0007530)	3.19126071
94	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.18772611
95	regulation of cellular respiration (GO:0043457)	3.18139124
96	resolution of meiotic recombination intermediates (GO:0000712)	3.17459918
97	cofactor catabolic process (GO:0051187)	3.16303634
98	glutamine family amino acid catabolic process (GO:0009065)	3.14854612
99	amine biosynthetic process (GO:0009309)	3.13961067
100	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.12856148

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	8.21691784
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.86750442
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	4.44076219
4	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.33657715
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.83804950
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.48336005
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.48256008
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.36930863
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32574994
10	VDR_22108803_ChIP-Seq_LS180_Human	2.25166502
11	FUS_26573619_Chip-Seq_HEK293_Human	2.00951634
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	11.6362940
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.94672562
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94672562
15	GATA1_22025678_ChIP-Seq_K562_Human	1.92988279
16	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.87731444
17	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.86020912
18	AR_21909140_ChIP-Seq_LNCAP_Human	1.84586165
19	AHR_22903824_ChIP-Seq_MCF-7_Human	1.73682381
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.67751960
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.67532670
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.66629809
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66443464
24	RAC3_21632823_ChIP-Seq_H3396_Human	1.64523768
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.62647249
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.58640259
27	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.54123311
28	ERA_21632823_ChIP-Seq_H3396_Human	1.50634431
29	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.47406704
30	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.45572152
31	TBL1_22424771_ChIP-Seq_293T_Human	1.40354322
32	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.35375767
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34026900
34	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.29767317
35	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29093092
36	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.28649847
37	OCT4_20526341_ChIP-Seq_ESCs_Human	1.28269675
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25752834
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22399055
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20486539
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.19698369
42	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.19271509
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19193164
44	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.18972417
45	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18611821
46	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17848380
47	MYC_19829295_ChIP-Seq_ESCs_Human	1.12285570
48	ERG_20517297_ChIP-Seq_VCAP_Human	1.10045678
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08518929
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.08518929
51	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08310910
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06990598
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06990598
54	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.06052844
55	TP53_18474530_ChIP-ChIP_U2OS_Human	1.05081973
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02904835
57	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.01301729
58	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00556836
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00053288
60	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.99593191
61	SMAD4_21799915_ChIP-Seq_A2780_Human	0.98989317
62	MYC_18940864_ChIP-ChIP_HL60_Human	0.98153229
63	RXR_22108803_ChIP-Seq_LS180_Human	0.97270591
64	AR_25329375_ChIP-Seq_VCAP_Human	0.95622414
65	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94648714
66	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.94565136
67	ELF5_23300383_ChIP-Seq_T47D_Human	0.92457749
68	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91082264
69	P300_19829295_ChIP-Seq_ESCs_Human	0.90614523
70	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.90525281
71	CTCF_27219007_Chip-Seq_Bcells_Human	0.89492406
72	PHF8_20622854_ChIP-Seq_HELA_Human	0.89290142
73	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.88982908
74	STAT3_23295773_ChIP-Seq_U87_Human	0.88663173
75	NFYB_21822215_ChIP-Seq_K562_Human	0.84644263
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84442134
77	SPI1_20517297_ChIP-Seq_HL60_Human	0.84345656
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.84245871
79	P300_27268052_Chip-Seq_Bcells_Human	0.83722526
80	SMC4_20622854_ChIP-Seq_HELA_Human	0.83045916
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82825153
82	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.82364111
83	STAT1_20625510_ChIP-Seq_HELA_Human	0.80902113
84	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.80151052
85	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.80030033
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.79728722
87	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.79487566
88	STAT1_17558387_ChIP-Seq_HELA_Human	0.79117294
89	PHF8_20622853_ChIP-Seq_HELA_Human	0.78068266
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.77225795
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.76887422
92	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.76804098
93	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.75629409
94	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.75603061
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.75498574
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.73900338
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.73855053
98	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.73085936
99	NCOR_22424771_ChIP-Seq_293T_Human	0.72914659
100	GATA3_26560356_Chip-Seq_TH1_Human	0.72008860

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008004_abnormal_stomach_pH	9.14089242
2	MP0005410_abnormal_fertilization	6.53863807
3	MP0003315_abnormal_perineum_morphology	5.51311196
4	MP0002160_abnormal_reproductive_system	4.01765571
5	MP0003698_abnormal_male_reproductive	3.01042959
6	MP0001929_abnormal_gametogenesis	2.89878645
7	MP0005389_reproductive_system_phenotype	2.61205589
8	MP0005647_abnormal_sex_gland	2.56279772
9	MP0001661_extended_life_span	2.52798700
10	MP0003136_yellow_coat_color	2.47592658
11	MP0002210_abnormal_sex_determination	2.45107576
12	MP0009697_abnormal_copulation	2.17655590
13	MP0005360_urolithiasis	2.16643560
14	MP0010386_abnormal_urinary_bladder	2.13099879
15	MP0001145_abnormal_male_reproductive	2.12727638
16	MP0001919_abnormal_reproductive_system	2.06882941
17	MP0008995_early_reproductive_senescence	2.01535420
18	MP0000653_abnormal_sex_gland	1.96088723
19	MP0000537_abnormal_urethra_morphology	1.85901829
20	MP0003045_fibrosis	1.85737018
21	MP0002638_abnormal_pupillary_reflex	1.84254895
22	MP0005058_abnormal_lysosome_morphology	1.80136993
23	MP0003718_maternal_effect	1.79553489
24	MP0010368_abnormal_lymphatic_system	1.78865964
25	MP0005187_abnormal_penis_morphology	1.78080996
26	MP0001664_abnormal_digestion	1.75761299
27	MP0002161_abnormal_fertility/fecundity	1.74180787
28	MP0000538_abnormal_urinary_bladder	1.65822895
29	MP0002132_abnormal_respiratory_system	1.43351498
30	MP0003011_delayed_dark_adaptation	1.41374813
31	MP0000465_gastrointestinal_hemorrhage	1.35758265
32	MP0001984_abnormal_olfaction	1.29236860
33	MP0008877_abnormal_DNA_methylation	1.25274100
34	MP0002127_abnormal_cardiovascular_syste	1.24279006
35	MP0004145_abnormal_muscle_electrophysio	1.19922796
36	MP0003936_abnormal_reproductive_system	1.18503529
37	MP0000678_abnormal_parathyroid_gland	1.17720603
38	MP0005394_taste/olfaction_phenotype	1.14223843
39	MP0005499_abnormal_olfactory_system	1.14223843
40	MP0004215_abnormal_myocardial_fiber	1.12157354
41	MP0003699_abnormal_female_reproductive	1.10287126
42	MP0000747_muscle_weakness	1.06160810
43	MP0008875_abnormal_xenobiotic_pharmacok	1.04457411
44	MP0001501_abnormal_sleep_pattern	1.01992158
45	MP0005171_absent_coat_pigmentation	0.99431934
46	MP0000470_abnormal_stomach_morphology	0.98937201
47	MP0003632_abnormal_nervous_system	0.98755288
48	MP0005334_abnormal_fat_pad	0.96429795
49	MP0003806_abnormal_nucleotide_metabolis	0.95484758
50	MP0001119_abnormal_female_reproductive	0.94632473
51	MP0008775_abnormal_heart_ventricle	0.93058215
52	MP0006036_abnormal_mitochondrial_physio	0.90769478
53	MP0002269_muscular_atrophy	0.89065508
54	MP0003693_abnormal_embryo_hatching	0.87533123
55	MP0009840_abnormal_foam_cell	0.86320438
56	MP0002332_abnormal_exercise_endurance	0.85427684
57	MP0000462_abnormal_digestive_system	0.84348650
58	MP0001849_ear_inflammation	0.83229844
59	MP0008058_abnormal_DNA_repair	0.82149049
60	MP0004084_abnormal_cardiac_muscle	0.81406107
61	MP0004036_abnormal_muscle_relaxation	0.80393214
62	MP0000627_abnormal_mammary_gland	0.79734422
63	MP0005551_abnormal_eye_electrophysiolog	0.79615592
64	MP0005253_abnormal_eye_physiology	0.78917599
65	MP0001968_abnormal_touch/_nociception	0.76416847
66	MP0006276_abnormal_autonomic_nervous	0.75999074
67	MP0003786_premature_aging	0.75864379
68	MP0006072_abnormal_retinal_apoptosis	0.74277292
69	MP0005395_other_phenotype	0.73768043
70	MP0002736_abnormal_nociception_after	0.72527774
71	MP0002876_abnormal_thyroid_physiology	0.70987419
72	MP0003300_gastrointestinal_ulcer	0.70146780
73	MP0001873_stomach_inflammation	0.69124478
74	MP0001502_abnormal_circadian_rhythm	0.68096247
75	MP0009250_abnormal_appendicular_skeleto	0.66772869
76	MP0000639_abnormal_adrenal_gland	0.64601450
77	MP0001905_abnormal_dopamine_level	0.64582334
78	MP0004233_abnormal_muscle_weight	0.64435935
79	MP0000049_abnormal_middle_ear	0.62496903
80	MP0004085_abnormal_heartbeat	0.60804998
81	MP0010329_abnormal_lipoprotein_level	0.60055803
82	MP0003953_abnormal_hormone_level	0.59050582
83	MP0005620_abnormal_muscle_contractility	0.57536146
84	MP0000372_irregular_coat_pigmentation	0.57485645
85	MP0005409_darkened_coat_color	0.57180145
86	MP0000343_altered_response_to	0.56598300
87	MP0002090_abnormal_vision	0.52935958
88	MP0004019_abnormal_vitamin_homeostasis	0.52128847
89	MP0008872_abnormal_physiological_respon	0.50795308
90	MP0002272_abnormal_nervous_system	0.49871041
91	MP0005595_abnormal_vascular_smooth	0.49832118
92	MP0005508_abnormal_skeleton_morphology	0.48996246
93	MP0004272_abnormal_basement_membrane	0.48456932
94	MP0003631_nervous_system_phenotype	0.46781687
95	MP0002837_dystrophic_cardiac_calcinosis	0.46490583
96	MP0004381_abnormal_hair_follicle	0.45704703
97	MP0008789_abnormal_olfactory_epithelium	0.45082356
98	MP0001963_abnormal_hearing_physiology	0.44893692
99	MP0005085_abnormal_gallbladder_physiolo	0.44850728
100	MP0008007_abnormal_cellular_replicative	0.44670018

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sex reversal (HP:0012245)	6.75421769
2	Abnormal sex determination (HP:0012244)	6.75421769
3	Hypoplasia of the uterus (HP:0000013)	6.43162932
4	Anomalous pulmonary venous return (HP:0010772)	5.43350803
5	Resting tremor (HP:0002322)	5.23512612
6	Male pseudohermaphroditism (HP:0000037)	5.12201745
7	Partial agenesis of the corpus callosum (HP:0001338)	4.73849700
8	Abnormality of the pulmonary veins (HP:0011718)	4.67247029
9	Aplasia/hypoplasia of the uterus (HP:0008684)	4.62487141
10	Abnormality of the columella (HP:0009929)	4.54035666
11	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.53204135
12	Gonadal dysgenesis (HP:0000133)	4.47595105
13	Reduced antithrombin III activity (HP:0001976)	4.34175448
14	Abnormality of the fovea (HP:0000493)	4.25967800
15	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.93258207
16	Hypoplasia of the fovea (HP:0007750)	3.93258207
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.92071028
18	Relative macrocephaly (HP:0004482)	3.91729420
19	Thoracic kyphosis (HP:0002942)	3.62741911
20	Facial hemangioma (HP:0000329)	3.54846389
21	Ventricular fibrillation (HP:0001663)	3.52529795
22	Ureteral duplication (HP:0000073)	3.49379237
23	Infertility (HP:0000789)	3.41551900
24	Cerebellar dysplasia (HP:0007033)	3.40316258
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.22360991
26	Absent/shortened dynein arms (HP:0200106)	3.22360991
27	Abnormal respiratory motile cilium physiology (HP:0012261)	3.17186466
28	Large earlobe (HP:0009748)	3.14398580
29	Retinal atrophy (HP:0001105)	3.08341467
30	Abnormal ciliary motility (HP:0012262)	2.98106865
31	Colitis (HP:0002583)	2.94144965
32	Postural instability (HP:0002172)	2.88371154
33	Flattened epiphyses (HP:0003071)	2.87006013
34	Capillary hemangiomas (HP:0005306)	2.85562376
35	Germ cell neoplasia (HP:0100728)	2.78802994
36	Self-mutilation (HP:0000742)	2.76716843
37	Thoracolumbar scoliosis (HP:0002944)	2.75496044
38	Cupped ear (HP:0000378)	2.70128631
39	Abnormal hemoglobin (HP:0011902)	2.65571797
40	Urinary urgency (HP:0000012)	2.49961410
41	Small epiphyses (HP:0010585)	2.48365551
42	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.44955583
43	Aplasia/Hypoplasia of the macula (HP:0008059)	2.37839521
44	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.36766020
45	Abnormality of the alveolar ridges (HP:0006477)	2.34476623
46	High pitched voice (HP:0001620)	2.30615561
47	Rhizomelia (HP:0008905)	2.29854034
48	Abnormality of the thoracic spine (HP:0100711)	2.28445335
49	Absent thumb (HP:0009777)	2.24563374
50	Inability to walk (HP:0002540)	2.22460388
51	Abnormality of the intrinsic pathway (HP:0010989)	2.20923319
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.20484384
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.20484384
54	Abnormal protein glycosylation (HP:0012346)	2.20484384
55	Abnormal glycosylation (HP:0012345)	2.20484384
56	Diastasis recti (HP:0001540)	2.19835801
57	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.15918937
58	Clubbing of toes (HP:0100760)	2.13081051
59	Abnormal rod and cone electroretinograms (HP:0008323)	2.11158015
60	Occipital encephalocele (HP:0002085)	2.09925460
61	Type II lissencephaly (HP:0007260)	2.09745687
62	Unsteady gait (HP:0002317)	2.08946957
63	Abnormality of the lumbar spine (HP:0100712)	2.07937037
64	Sensory axonal neuropathy (HP:0003390)	2.07098118
65	Aplasia cutis congenita (HP:0001057)	2.06209948
66	Rhinitis (HP:0012384)	2.05834415
67	Oligodactyly (hands) (HP:0001180)	2.03247210
68	Gonadotropin excess (HP:0000837)	2.02933463
69	Abnormality of the frontal sinuses (HP:0002687)	2.02455306
70	Abnormal respiratory epithelium morphology (HP:0012253)	2.00742217
71	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00742217
72	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.99999213
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.99035786
74	Azoospermia (HP:0000027)	1.98098598
75	Mixed hearing impairment (HP:0000410)	1.97715081
76	Atonic seizures (HP:0010819)	1.95742616
77	Abnormality of the pons (HP:0007361)	1.93123289
78	Cerebral palsy (HP:0100021)	1.87470524
79	Anteriorly placed anus (HP:0001545)	1.85692443
80	Inflammation of the large intestine (HP:0002037)	1.85485722
81	Premature ovarian failure (HP:0008209)	1.83635108
82	Syncope (HP:0001279)	1.81924412
83	Coxa valga (HP:0002673)	1.81868753
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80952259
85	Short nail (HP:0001799)	1.79821852
86	Mitral stenosis (HP:0001718)	1.79736474
87	Abnormality of male internal genitalia (HP:0000022)	1.78903453
88	Duodenal stenosis (HP:0100867)	1.76851568
89	Small intestinal stenosis (HP:0012848)	1.76851568
90	Absent epiphyses (HP:0010577)	1.76361584
91	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.76361584
92	Protruding tongue (HP:0010808)	1.74960274
93	Abnormal pancreas size (HP:0012094)	1.74166585
94	Hypothermia (HP:0002045)	1.74045815
95	Hypergonadotropic hypogonadism (HP:0000815)	1.72110906
96	Prolonged QT interval (HP:0001657)	1.70768756
97	Exercise-induced myalgia (HP:0003738)	1.70393377
98	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.70133046
99	Hypoplasia of the pons (HP:0012110)	1.69874467
100	Congenital sensorineural hearing impairment (HP:0008527)	1.69257332

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	5.90953762
2	TLK1	4.88313078
3	ZAK	3.83802206
4	PDK2	3.08740593
5	RPS6KA5	3.01784098
6	NEK2	2.75935009
7	MYLK	2.62355993
8	PINK1	10.7516685
9	VRK1	1.87768798
10	PRPF4B	1.82348101
11	CCNB1	1.40707293
12	CDK3	1.27889061
13	EIF2AK3	1.24537210
14	STK38	1.21950221
15	LATS1	1.12755037
16	STK38L	1.06484676
17	TAOK2	1.02081666
18	DYRK3	0.93980825
19	MAP2K7	0.93363913
20	MELK	0.90975240
21	SGK494	0.86299890
22	SGK223	0.86299890
23	CDC7	0.77719790
24	TIE1	0.75851025
25	MAP3K2	0.75605499
26	MAPK12	0.74228122
27	CAMK4	0.74177806
28	MAP3K5	0.71848731
29	CAMK1D	0.71144515
30	OBSCN	0.69658245
31	BMPR2	0.68304531
32	CDK12	0.63712092
33	MAP3K9	0.63010997
34	DYRK2	0.62561566
35	PDPK1	0.61887377
36	CAMK1	0.61621954
37	PDK1	0.60402308
38	ICK	0.58631154
39	FGR	0.54464293
40	JAK2	0.54314575
41	TYRO3	0.53652590
42	MAP3K1	0.52156899
43	AURKA	0.51527572
44	PKN1	0.50370305
45	PBK	0.49234729
46	PRKG2	0.48761998
47	BRAF	0.48761459
48	AKT2	0.47891209
49	CDK8	0.47117805
50	CDC42BPA	0.44750854
51	LATS2	0.44647610
52	PLK4	0.44326030
53	AKT3	0.43760865
54	TAOK3	0.43123006
55	FRK	0.42072438
56	MST1R	0.41952517
57	CDK4	0.41498255
58	PRKCQ	0.41435935
59	MAPK15	0.41336619
60	CDK14	0.40671528
61	MAP3K13	0.39400702
62	DAPK3	0.39318456
63	ATM	0.37552365
64	CDK5	0.36891844
65	WNK1	0.35849584
66	PAK1	0.35174147
67	SGK2	0.34065776
68	PTK2B	0.33648518
69	RPS6KB1	0.33539672
70	TTK	0.32861901
71	NEK6	0.32623405
72	PIM1	0.30543020
73	ADRBK2	0.29518076
74	JAK3	0.29503123
75	MAP3K11	0.28365369
76	BLK	0.28214996
77	CHEK2	0.26679913
78	SIK2	0.25690338
79	MET	0.25543935
80	BMPR1B	0.25019014
81	PAK2	0.24375322
82	MAP4K1	0.23434590
83	STK11	0.22080420
84	PLK1	0.21090218
85	MAPK1	0.20666474
86	AURKB	0.19301717
87	MAP2K2	0.18739200
88	MAP2K1	0.17252353
89	EGFR	0.16666508
90	CAMK1G	0.16379850
91	IRAK2	0.16160505
92	GRK1	0.15876016
93	ATR	0.15358848
94	CSNK1A1	0.14954832
95	IRAK4	0.14557160
96	MST4	0.14334804
97	RET	0.13864102
98	RPS6KA4	0.13756545
99	PRKG1	0.13699135
100	ROCK1	0.13288153

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	5.78560872
2	Gap junction_Homo sapiens_hsa04540	4.03251960
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.12374818
4	Olfactory transduction_Homo sapiens_hsa04740	2.68986373
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.64040056
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.63589051
7	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.46536905
8	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.44951986
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.38857319
10	Apoptosis_Homo sapiens_hsa04210	2.28961174
11	Pyruvate metabolism_Homo sapiens_hsa00620	2.24758161
12	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.13518604
13	Phagosome_Homo sapiens_hsa04145	2.12918025
14	Propanoate metabolism_Homo sapiens_hsa00640	2.06769598
15	Alcoholism_Homo sapiens_hsa05034	2.04635380
16	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.00347333
17	Glutathione metabolism_Homo sapiens_hsa00480	1.93576535
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.76077168
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.75517512
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.65861843
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.59822488
22	Butanoate metabolism_Homo sapiens_hsa00650	1.58960673
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.58122271
24	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.52425986
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.47076272
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38472024
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.32507658
28	Basal transcription factors_Homo sapiens_hsa03022	1.29577706
29	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.17773199
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.10797097
31	Ribosome_Homo sapiens_hsa03010	1.08975141
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08279011
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.03260739
34	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.02727299
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02167985
36	Circadian rhythm_Homo sapiens_hsa04710	1.01562592
37	Oocyte meiosis_Homo sapiens_hsa04114	0.98513539
38	Parkinsons disease_Homo sapiens_hsa05012	0.94323178
39	Pentose phosphate pathway_Homo sapiens_hsa00030	0.92726070
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91748701
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89684534
42	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.88549300
43	mRNA surveillance pathway_Homo sapiens_hsa03015	0.87352528
44	RNA degradation_Homo sapiens_hsa03018	0.87305035
45	Fatty acid degradation_Homo sapiens_hsa00071	0.85689973
46	Taste transduction_Homo sapiens_hsa04742	0.85537262
47	Histidine metabolism_Homo sapiens_hsa00340	0.85311705
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.84107894
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83979500
50	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.82315847
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.81748889
52	Glucagon signaling pathway_Homo sapiens_hsa04922	0.79026121
53	One carbon pool by folate_Homo sapiens_hsa00670	0.78729684
54	DNA replication_Homo sapiens_hsa03030	0.77981554
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.71062239
56	Gastric acid secretion_Homo sapiens_hsa04971	0.67552715
57	Sulfur relay system_Homo sapiens_hsa04122	0.66352908
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65305949
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63210540
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62380627
61	Purine metabolism_Homo sapiens_hsa00230	0.58959512
62	RNA transport_Homo sapiens_hsa03013	0.56271503
63	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.53858121
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52248658
65	Metabolic pathways_Homo sapiens_hsa01100	0.50012123
66	Choline metabolism in cancer_Homo sapiens_hsa05231	0.49573912
67	ABC transporters_Homo sapiens_hsa02010	0.48931825
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48561062
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.48046131
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.47583802
71	PPAR signaling pathway_Homo sapiens_hsa03320	0.47274589
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.45993692
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44017322
74	Bile secretion_Homo sapiens_hsa04976	0.43867378
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43796299
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43326879
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42552009
78	Peroxisome_Homo sapiens_hsa04146	0.41628912
79	Huntingtons disease_Homo sapiens_hsa05016	0.40670304
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.39547353
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.39291033
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37994436
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36852359
84	Spliceosome_Homo sapiens_hsa03040	0.36215520
85	Regulation of autophagy_Homo sapiens_hsa04140	0.34126550
86	Retinol metabolism_Homo sapiens_hsa00830	0.33785706
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33321271
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31340528
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.28699444
90	Alzheimers disease_Homo sapiens_hsa05010	0.28093303
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26936588
92	Lysine degradation_Homo sapiens_hsa00310	0.26494495
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.25691787
94	ECM-receptor interaction_Homo sapiens_hsa04512	0.25208608
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.24931791
96	Oxidative phosphorylation_Homo sapiens_hsa00190	0.24229648
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.23908836
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.22163421
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.21527755
100	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.17579959

DCAF8L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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