DCAKD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.62316864
2peptidyl-arginine omega-N-methylation (GO:0035247)4.43842782
3paraxial mesoderm development (GO:0048339)4.43299942
4pyrimidine nucleobase catabolic process (GO:0006208)4.39942116
5histone arginine methylation (GO:0034969)4.16895592
6presynaptic membrane assembly (GO:0097105)4.04251356
7peptidyl-arginine methylation (GO:0018216)3.95865076
8peptidyl-arginine N-methylation (GO:0035246)3.95865076
9DNA strand elongation involved in DNA replication (GO:0006271)3.95092186
10presynaptic membrane organization (GO:0097090)3.80141855
11protein localization to kinetochore (GO:0034501)3.79818529
12postsynaptic membrane organization (GO:0001941)3.74059324
13DNA strand elongation (GO:0022616)3.74041436
14mitotic metaphase plate congression (GO:0007080)3.70674534
15DNA replication-dependent nucleosome assembly (GO:0006335)3.69185715
16DNA replication-dependent nucleosome organization (GO:0034723)3.69185715
17DNA replication initiation (GO:0006270)3.69001681
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60716920
19nucleobase catabolic process (GO:0046113)3.53608912
20mitotic nuclear envelope disassembly (GO:0007077)3.50724167
21formation of translation preinitiation complex (GO:0001731)3.46383901
22protein polyglutamylation (GO:0018095)3.46140057
23pre-miRNA processing (GO:0031054)3.45033649
24protein complex biogenesis (GO:0070271)3.44234787
25regulation of gene silencing by RNA (GO:0060966)3.40956745
26regulation of posttranscriptional gene silencing (GO:0060147)3.40956745
27regulation of gene silencing by miRNA (GO:0060964)3.40956745
28spliceosomal snRNP assembly (GO:0000387)3.38976054
29DNA replication checkpoint (GO:0000076)3.37618778
30telomere maintenance via semi-conservative replication (GO:0032201)3.36054611
31protein-DNA complex disassembly (GO:0032986)3.31590404
32nucleosome disassembly (GO:0006337)3.31590404
33mitotic sister chromatid segregation (GO:0000070)3.29461915
34behavioral response to nicotine (GO:0035095)3.27658724
35positive regulation of mitochondrial fission (GO:0090141)3.26243776
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24192730
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.24192730
38NADH dehydrogenase complex assembly (GO:0010257)3.24192730
39membrane disassembly (GO:0030397)3.22674360
40nuclear envelope disassembly (GO:0051081)3.22674360
41neuron cell-cell adhesion (GO:0007158)3.21611585
42negative regulation of RNA splicing (GO:0033119)3.19872025
43epithelial cilium movement (GO:0003351)3.19457690
44nucleobase biosynthetic process (GO:0046112)3.18743040
45cullin deneddylation (GO:0010388)3.18599673
46metaphase plate congression (GO:0051310)3.17712413
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17525313
48gamma-aminobutyric acid transport (GO:0015812)3.14283538
49spliceosomal complex assembly (GO:0000245)3.13364000
50heterochromatin organization (GO:0070828)3.12519943
51negative regulation of chromosome segregation (GO:0051985)3.09143699
52nonmotile primary cilium assembly (GO:0035058)3.08921394
53establishment of integrated proviral latency (GO:0075713)3.08900328
54sister chromatid segregation (GO:0000819)3.08230899
55protein localization to chromosome, centromeric region (GO:0071459)3.07617588
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07587793
57mitochondrial respiratory chain complex assembly (GO:0033108)3.04862994
58folic acid-containing compound biosynthetic process (GO:0009396)3.04377330
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.03255894
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03255894
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03255894
62negative regulation of sister chromatid segregation (GO:0033046)3.03255894
63mitotic spindle assembly checkpoint (GO:0007094)3.02740344
64negative regulation of mRNA processing (GO:0050686)3.01927560
65kinetochore assembly (GO:0051382)3.01869440
66histone H2A acetylation (GO:0043968)3.01245543
67nuclear pore organization (GO:0006999)3.00629792
68RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99142879
69mRNA splicing, via spliceosome (GO:0000398)2.99142879
70regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98615433
71RNA splicing, via transesterification reactions (GO:0000375)2.98507775
72spindle assembly checkpoint (GO:0071173)2.97970497
73kinetochore organization (GO:0051383)2.96612749
74protein deneddylation (GO:0000338)2.96065771
75mitotic recombination (GO:0006312)2.95342648
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93063037
77telomere maintenance via recombination (GO:0000722)2.92967972
78water-soluble vitamin biosynthetic process (GO:0042364)2.92738087
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92124450
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90441082
81dosage compensation (GO:0007549)2.90352627
82DNA double-strand break processing (GO:0000729)2.90051356
83IMP biosynthetic process (GO:0006188)2.87470070
84notochord development (GO:0030903)2.87389946
85regulation of cilium movement (GO:0003352)2.87255219
86purine nucleobase biosynthetic process (GO:0009113)2.86006578
87mitotic spindle checkpoint (GO:0071174)2.84385733
88telomere maintenance via telomere lengthening (GO:0010833)2.83363139
89nodal signaling pathway (GO:0038092)2.81863995
90spindle checkpoint (GO:0031577)2.80661824
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.78698723
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77718344
93DNA duplex unwinding (GO:0032508)2.76334082
94DNA geometric change (GO:0032392)2.75992968
95ribosome biogenesis (GO:0042254)2.75878315
96protein neddylation (GO:0045116)2.75838134
97mitotic chromosome condensation (GO:0007076)2.74788840
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.73262252
99termination of RNA polymerase II transcription (GO:0006369)2.73086163
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72992131
101establishment of chromosome localization (GO:0051303)2.72920047
102viral mRNA export from host cell nucleus (GO:0046784)2.72280151
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72075114
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.72075114
105nuclear pore complex assembly (GO:0051292)2.71873993
106maturation of SSU-rRNA (GO:0030490)2.70517763
107regulation of chromosome segregation (GO:0051983)2.70318689
108cell proliferation in forebrain (GO:0021846)2.68541857
109DNA deamination (GO:0045006)2.67574883
110DNA replication-independent nucleosome organization (GO:0034724)2.67461412
111DNA replication-independent nucleosome assembly (GO:0006336)2.67461412
112cilium morphogenesis (GO:0060271)2.66635162
113dendritic spine morphogenesis (GO:0060997)2.66286841
114cornea development in camera-type eye (GO:0061303)2.65930645
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65803645
116axoneme assembly (GO:0035082)2.65277819
117chromatin remodeling at centromere (GO:0031055)2.64347031
118preassembly of GPI anchor in ER membrane (GO:0016254)2.63320559
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63169342
120regulation of sister chromatid segregation (GO:0033045)2.62547682
121regulation of mitotic sister chromatid separation (GO:0010965)2.62547682
122regulation of mitotic sister chromatid segregation (GO:0033047)2.62547682
123CENP-A containing nucleosome assembly (GO:0034080)2.62258572
124regulation of sister chromatid cohesion (GO:0007063)2.62156648
125somite development (GO:0061053)2.61459956
126base-excision repair (GO:0006284)2.61209597
127cilium movement (GO:0003341)2.60430859
128ATP-dependent chromatin remodeling (GO:0043044)2.60090990
129regulation of neurotransmitter uptake (GO:0051580)2.59486487
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.58608316
131hindbrain development (GO:0030902)2.57701711
132intraciliary transport (GO:0042073)2.56423373
133regulation of mesoderm development (GO:2000380)2.56389114
134ATP synthesis coupled proton transport (GO:0015986)2.56058787
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56058787
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56026888
137nephron tubule morphogenesis (GO:0072078)2.55943447
138nephron epithelium morphogenesis (GO:0072088)2.55943447
139cellular ketone body metabolic process (GO:0046950)2.55719097
140spinal cord development (GO:0021510)2.55074085
141mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.54377632
142auditory behavior (GO:0031223)2.54097334
143establishment of apical/basal cell polarity (GO:0035089)2.54012852
144limb development (GO:0060173)2.53753827
145appendage development (GO:0048736)2.53753827
146mannosylation (GO:0097502)2.53639425
147regulation of DNA damage checkpoint (GO:2000001)2.53615167
148establishment of protein localization to mitochondrial membrane (GO:0090151)2.53549985
149negative regulation of telomere maintenance (GO:0032205)2.52638524
150protein localization to synapse (GO:0035418)2.50956559
151chaperone-mediated protein transport (GO:0072321)2.48510812
152regulation of female receptivity (GO:0045924)2.46783345
153replication fork processing (GO:0031297)2.44256428
154transmission of nerve impulse (GO:0019226)2.41018653
155cilium organization (GO:0044782)2.40954546
156limb bud formation (GO:0060174)2.39681205
157protein K6-linked ubiquitination (GO:0085020)2.39022778
158synapse assembly (GO:0007416)2.38543439
159response to nitrosative stress (GO:0051409)2.38200822
160retinal ganglion cell axon guidance (GO:0031290)2.37404742
161regulation of action potential (GO:0098900)2.36582367
162electron transport chain (GO:0022900)2.36343558
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36236716
164respiratory chain complex IV assembly (GO:0008535)2.36002443
165aggressive behavior (GO:0002118)2.35776108
166negative regulation of response to food (GO:0032096)2.35061677
167negative regulation of appetite (GO:0032099)2.35061677
168cilium assembly (GO:0042384)2.33644233
169mechanosensory behavior (GO:0007638)2.33321068
170negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32712441
171regulation of microtubule-based movement (GO:0060632)2.32632176
172respiratory electron transport chain (GO:0022904)2.32149185
173axonal fasciculation (GO:0007413)2.32101559
174negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.31131807
175positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31023604
176inner mitochondrial membrane organization (GO:0007007)2.29519037
177calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29061439
178hippocampus development (GO:0021766)2.27254049
179startle response (GO:0001964)2.27113767
180ketone body metabolic process (GO:1902224)2.25994675
181L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.25542859
182membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.25417546
183G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.24390135
184exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.23797536
185positive regulation of oligodendrocyte differentiation (GO:0048714)2.22290929
186regulation of development, heterochronic (GO:0040034)2.22200835
187cellular biogenic amine catabolic process (GO:0042402)2.21926929
188amine catabolic process (GO:0009310)2.21926929
189GPI anchor metabolic process (GO:0006505)2.21183366
190tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.20461425
191RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.20461425
192response to misfolded protein (GO:0051788)2.20410148
193indolalkylamine metabolic process (GO:0006586)2.20307252
194regulation of collateral sprouting (GO:0048670)2.19380116
195regulation of timing of cell differentiation (GO:0048505)2.18998114
196cell differentiation in spinal cord (GO:0021515)2.18758392
197sequestering of actin monomers (GO:0042989)2.18411958
198epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.18320606
199photoreceptor cell development (GO:0042461)2.17239586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.35543858
2EZH2_22144423_ChIP-Seq_EOC_Human4.66417921
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.17808683
4* MYC_18555785_ChIP-Seq_MESCs_Mouse4.12695220
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39290811
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22681142
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12674759
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07501520
9ZNF274_21170338_ChIP-Seq_K562_Hela3.03286718
10GBX2_23144817_ChIP-Seq_PC3_Human2.87324176
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.85265544
12IGF1R_20145208_ChIP-Seq_DFB_Human2.79751221
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77336957
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69141769
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63042130
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57383723
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53852221
18XRN2_22483619_ChIP-Seq_HELA_Human2.52455810
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47016226
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46147699
21* EST1_17652178_ChIP-ChIP_JURKAT_Human2.43851197
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.41730193
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29598880
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29370208
25* ETS1_20019798_ChIP-Seq_JURKAT_Human2.27022475
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.25852215
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22984346
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19288704
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.12510575
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11798588
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07762732
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06301097
33CBX2_27304074_Chip-Seq_ESCs_Mouse2.06113562
34RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05048306
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03807959
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00988087
37VDR_22108803_ChIP-Seq_LS180_Human1.99123908
38REST_21632747_ChIP-Seq_MESCs_Mouse1.97284178
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96008629
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94493254
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94251936
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.92535018
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92290805
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89216638
45AR_21909140_ChIP-Seq_LNCAP_Human1.88182558
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.86548550
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.85820406
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84301224
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83484870
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83370619
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81937840
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81477201
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80739294
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.79281863
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79141840
56FUS_26573619_Chip-Seq_HEK293_Human1.78044423
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77976057
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77741541
59TTF2_22483619_ChIP-Seq_HELA_Human1.77625387
60EWS_26573619_Chip-Seq_HEK293_Human1.76983504
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.76820016
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73436696
63RNF2_27304074_Chip-Seq_NSC_Mouse1.73390904
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.71997585
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71843749
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71567275
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.68468555
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68196898
69* GABP_19822575_ChIP-Seq_HepG2_Human1.67157072
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65929975
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63420751
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.63380532
73CIITA_25753668_ChIP-Seq_RAJI_Human1.63202914
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63173065
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63173065
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63173065
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62968144
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62359308
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61813656
80TAF15_26573619_Chip-Seq_HEK293_Human1.61619790
81DCP1A_22483619_ChIP-Seq_HELA_Human1.60061108
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58438059
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58353269
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53952107
85P300_19829295_ChIP-Seq_ESCs_Human1.51108434
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50798484
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47484124
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47158718
89* MYC_22102868_ChIP-Seq_BL_Human1.46884285
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.42520094
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41636880
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40548273
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40251108
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38255269
95FOXP3_21729870_ChIP-Seq_TREG_Human1.36355680
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36112272
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36078206
98VDR_23849224_ChIP-Seq_CD4+_Human1.35882342
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35736694
100IRF1_19129219_ChIP-ChIP_H3396_Human1.35436943
101TP53_22573176_ChIP-Seq_HFKS_Human1.34610319
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34013007
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32767194
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31656496
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30679390
106SMAD4_21799915_ChIP-Seq_A2780_Human1.30463071
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28981760
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28871460
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27166710
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.26764299
111KDM5A_27292631_Chip-Seq_BREAST_Human1.25234391
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21962279
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21856666
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21438704
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20888916
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20725322
117* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20463328
118SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20326310
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19831238
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19187060
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19169926
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19028737
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18228466
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17781627
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17131524
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16688383
127BCAT_22108803_ChIP-Seq_LS180_Human1.14773684
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13372946
129POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12799337
130SOX2_16153702_ChIP-ChIP_HESCs_Human1.12275030
131ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11936065
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10910428
133RNF2_27304074_Chip-Seq_ESCs_Mouse1.10519329
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10427961
135FLI1_27457419_Chip-Seq_LIVER_Mouse1.09331643
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09081445
137NANOG_16153702_ChIP-ChIP_HESCs_Human1.08979020
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08409755
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08126905
140EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07507322
141RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07507322
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07132803
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06940440
144SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06901250
145ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06089085
146PIAS1_25552417_ChIP-Seq_VCAP_Human1.05540911
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04652187
148STAT3_23295773_ChIP-Seq_U87_Human1.04235734
149AR_25329375_ChIP-Seq_VCAP_Human1.04172207
150ER_23166858_ChIP-Seq_MCF-7_Human1.03768362
151* TCF4_23295773_ChIP-Seq_U87_Human1.02695255
152CBP_20019798_ChIP-Seq_JUKART_Human1.02588609
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02588609
154KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02526944
155NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02374232
156CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01715742
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01372506
158SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00004730
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99098414
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.99051096
161POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97678165
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96967431
163CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96415689
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96070237
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95788753
166SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94231575
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93970544
168HTT_18923047_ChIP-ChIP_STHdh_Human0.93736382
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93735503
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93735503
171E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93708697
172ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93212156
173ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92996927
174NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92872785
175FOXA1_25329375_ChIP-Seq_VCAP_Human0.92780276
176FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92780276
177HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92717852
178CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92280520
179RUNX2_22187159_ChIP-Seq_PCA_Human0.92105765
180HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92003653
181MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90807686
182MYC_18940864_ChIP-ChIP_HL60_Human0.88724840
183SRF_21415370_ChIP-Seq_HL-1_Mouse0.87532045
184ELK1_19687146_ChIP-ChIP_HELA_Human0.85566361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.87469597
2MP0004957_abnormal_blastocyst_morpholog3.01610985
3MP0003123_paternal_imprinting2.94615323
4MP0003693_abnormal_embryo_hatching2.93107062
5MP0003111_abnormal_nucleus_morphology2.83083286
6MP0010094_abnormal_chromosome_stability2.82865886
7MP0002653_abnormal_ependyma_morphology2.77597772
8MP0003077_abnormal_cell_cycle2.71813295
9MP0009053_abnormal_anal_canal2.60107499
10MP0003880_abnormal_central_pattern2.53417285
11MP0003787_abnormal_imprinting2.49816813
12MP0001968_abnormal_touch/_nociception2.48198566
13MP0005646_abnormal_pituitary_gland2.46869254
14MP0003122_maternal_imprinting2.43305412
15MP0003890_abnormal_embryonic-extraembry2.40750900
16MP0008932_abnormal_embryonic_tissue2.36429785
17MP0000537_abnormal_urethra_morphology2.33686118
18MP0002736_abnormal_nociception_after2.30800451
19MP0003119_abnormal_digestive_system2.29394963
20MP0003121_genomic_imprinting2.26810154
21MP0005645_abnormal_hypothalamus_physiol2.26006261
22MP0004133_heterotaxia2.22207378
23MP0001529_abnormal_vocalization2.19361658
24MP0002638_abnormal_pupillary_reflex2.16807176
25MP0002249_abnormal_larynx_morphology2.08053792
26MP0000049_abnormal_middle_ear2.06022957
27MP0001984_abnormal_olfaction2.01821362
28MP0008057_abnormal_DNA_replication1.98670205
29MP0008007_abnormal_cellular_replicative1.98266769
30MP0004859_abnormal_synaptic_plasticity1.97911919
31MP0000631_abnormal_neuroendocrine_gland1.97072526
32MP0001730_embryonic_growth_arrest1.95007962
33MP0006292_abnormal_olfactory_placode1.94916207
34MP0006276_abnormal_autonomic_nervous1.93261301
35MP0009046_muscle_twitch1.91605041
36MP0002085_abnormal_embryonic_tissue1.90721912
37MP0008058_abnormal_DNA_repair1.89542544
38MP0005423_abnormal_somatic_nervous1.87041494
39MP0002735_abnormal_chemical_nociception1.86429736
40MP0009745_abnormal_behavioral_response1.84974582
41MP0003942_abnormal_urinary_system1.84626711
42MP0004885_abnormal_endolymph1.82118279
43MP0002084_abnormal_developmental_patter1.82000293
44MP0006072_abnormal_retinal_apoptosis1.80928441
45MP0000350_abnormal_cell_proliferation1.79693655
46MP0001672_abnormal_embryogenesis/_devel1.79410398
47MP0005380_embryogenesis_phenotype1.79410398
48MP0002272_abnormal_nervous_system1.78981826
49MP0000566_synostosis1.77214224
50MP0004142_abnormal_muscle_tone1.76558915
51MP0000778_abnormal_nervous_system1.76125921
52MP0002876_abnormal_thyroid_physiology1.74476810
53MP0001697_abnormal_embryo_size1.73005589
54MP0002572_abnormal_emotion/affect_behav1.70307653
55MP0001905_abnormal_dopamine_level1.70305346
56MP0003385_abnormal_body_wall1.69879901
57MP0003635_abnormal_synaptic_transmissio1.68920611
58MP0005551_abnormal_eye_electrophysiolog1.67137229
59MP0002822_catalepsy1.66943034
60MP0001293_anophthalmia1.66074760
61MP0003315_abnormal_perineum_morphology1.66064217
62MP0003937_abnormal_limbs/digits/tail_de1.64817713
63MP0004233_abnormal_muscle_weight1.64455536
64MP0004270_analgesia1.63539222
65MP0003984_embryonic_growth_retardation1.63510533
66MP0008872_abnormal_physiological_respon1.62857686
67MP0002088_abnormal_embryonic_growth/wei1.61021948
68MP0004197_abnormal_fetal_growth/weight/1.59034542
69MP0002064_seizures1.58092199
70MP0002063_abnormal_learning/memory/cond1.56714763
71MP0005253_abnormal_eye_physiology1.54212044
72MP0005076_abnormal_cell_differentiation1.53826508
73MP0008877_abnormal_DNA_methylation1.52983510
74MP0002932_abnormal_joint_morphology1.51500425
75MP0002557_abnormal_social/conspecific_i1.50159108
76MP0001486_abnormal_startle_reflex1.49834792
77MP0002837_dystrophic_cardiac_calcinosis1.49043871
78MP0003115_abnormal_respiratory_system1.48629508
79MP0002733_abnormal_thermal_nociception1.45797943
80MP0003705_abnormal_hypodermis_morpholog1.45679762
81MP0003567_abnormal_fetal_cardiomyocyte1.44142985
82MP0002909_abnormal_adrenal_gland1.43190400
83MP0001970_abnormal_pain_threshold1.42587599
84MP0003283_abnormal_digestive_organ1.41740384
85MP0008789_abnormal_olfactory_epithelium1.41375413
86MP0000534_abnormal_ureter_morphology1.41213638
87MP0000428_abnormal_craniofacial_morphol1.41078626
88MP0003755_abnormal_palate_morphology1.39833379
89MP0002734_abnormal_mechanical_nocicepti1.38970731
90MP0000678_abnormal_parathyroid_gland1.37684957
91MP0002080_prenatal_lethality1.37563590
92MP0002282_abnormal_trachea_morphology1.37502335
93MP0003935_abnormal_craniofacial_develop1.34870649
94MP0002111_abnormal_tail_morphology1.34612441
95MP0005084_abnormal_gallbladder_morpholo1.34079703
96MP0002938_white_spotting1.31926164
97MP0002086_abnormal_extraembryonic_tissu1.29177947
98MP0001485_abnormal_pinna_reflex1.28815051
99MP0000372_irregular_coat_pigmentation1.28647400
100MP0002234_abnormal_pharynx_morphology1.25102574
101MP0003861_abnormal_nervous_system1.24262793
102MP0002116_abnormal_craniofacial_bone1.20880094
103MP0001286_abnormal_eye_development1.20374910
104MP0003136_yellow_coat_color1.18670656
105MP0010352_gastrointestinal_tract_polyps1.18167912
106MP0002184_abnormal_innervation1.17794142
107MP0002067_abnormal_sensory_capabilities1.17613414
108MP0002751_abnormal_autonomic_nervous1.14168324
109MP0000955_abnormal_spinal_cord1.13478957
110MP0002233_abnormal_nose_morphology1.13043558
111MP0001986_abnormal_taste_sensitivity1.12402709
112MP0000026_abnormal_inner_ear1.11738100
113MP0005394_taste/olfaction_phenotype1.11152089
114MP0005499_abnormal_olfactory_system1.11152089
115MP0003941_abnormal_skin_development1.10745018
116MP0002697_abnormal_eye_size1.09984470
117MP0003938_abnormal_ear_development1.09799170
118MP0009250_abnormal_appendicular_skeleto1.08541967
119MP0004742_abnormal_vestibular_system1.08156749
120MP0002882_abnormal_neuron_morphology1.07485230
121MP0009672_abnormal_birth_weight1.07380749
122MP0000432_abnormal_head_morphology1.07005158
123MP0005386_behavior/neurological_phenoty1.06209329
124MP0004924_abnormal_behavior1.06209329
125MP0005171_absent_coat_pigmentation1.03925249
126MP0001502_abnormal_circadian_rhythm1.03584002
127MP0002752_abnormal_somatic_nervous1.01748862
128MP0005248_abnormal_Harderian_gland1.00329355
129MP0009780_abnormal_chondrocyte_physiolo0.99769925
130MP0003011_delayed_dark_adaptation0.99761517
131MP0002092_abnormal_eye_morphology0.97687187
132MP0002114_abnormal_axial_skeleton0.96987634
133MP0008995_early_reproductive_senescence0.95680371
134MP0001963_abnormal_hearing_physiology0.95183836
135MP0001849_ear_inflammation0.93325953
136MP0002152_abnormal_brain_morphology0.91033739
137MP0004811_abnormal_neuron_physiology0.90920598
138MP0002127_abnormal_cardiovascular_syste0.90645400
139MP0002928_abnormal_bile_duct0.89634794
140MP0000750_abnormal_muscle_regeneration0.89250019
141MP0005195_abnormal_posterior_eye0.89229005
142MP0000013_abnormal_adipose_tissue0.88807632
143MP0000313_abnormal_cell_death0.87832177
144MP0003137_abnormal_impulse_conducting0.87395295
145MP0009703_decreased_birth_body0.86461126
146MP0005367_renal/urinary_system_phenotyp0.84270038
147MP0000516_abnormal_urinary_system0.84270038
148MP0002925_abnormal_cardiovascular_devel0.83034009
149MP0001944_abnormal_pancreas_morphology0.82735068
150MP0005379_endocrine/exocrine_gland_phen0.82617549
151MP0005187_abnormal_penis_morphology0.82193084
152MP0005503_abnormal_tendon_morphology0.81885726
153MP0002210_abnormal_sex_determination0.81361132
154MP0002081_perinatal_lethality0.80695657
155MP0004145_abnormal_muscle_electrophysio0.80574394
156MP0002066_abnormal_motor_capabilities/c0.80010463
157MP0002102_abnormal_ear_morphology0.79972075
158MP0002160_abnormal_reproductive_system0.79864583
159MP0005508_abnormal_skeleton_morphology0.79595249
160MP0000762_abnormal_tongue_morphology0.78723893
161MP0003718_maternal_effect0.78081096
162MP0000266_abnormal_heart_morphology0.76334795
163MP0002069_abnormal_eating/drinking_beha0.75339475
164MP0000733_abnormal_muscle_development0.75243354
165MP0001915_intracranial_hemorrhage0.73991521
166MP0002163_abnormal_gland_morphology0.73746818
167MP0003786_premature_aging0.72156511
168MP0004084_abnormal_cardiac_muscle0.72060283
169MP0005083_abnormal_biliary_tract0.71723545
170MP0005257_abnormal_intraocular_pressure0.71475171
171MP0002109_abnormal_limb_morphology0.71441310
172MP0005391_vision/eye_phenotype0.70886407
173MP0001145_abnormal_male_reproductive0.70006236
174MP0004147_increased_porphyrin_level0.69960339

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.58961968
2Short 4th metacarpal (HP:0010044)3.58961968
3Renal duplication (HP:0000075)3.47354581
4Pancreatic fibrosis (HP:0100732)3.39560271
5Patellar aplasia (HP:0006443)3.39219211
6Acute necrotizing encephalopathy (HP:0006965)3.37891425
7True hermaphroditism (HP:0010459)3.31555924
8Pancreatic cysts (HP:0001737)3.29301890
9Ependymoma (HP:0002888)3.27641482
10Aplasia/Hypoplasia of the patella (HP:0006498)3.25362954
11Nephronophthisis (HP:0000090)3.21259661
12Medulloblastoma (HP:0002885)3.17631340
13Selective tooth agenesis (HP:0001592)3.08587077
14Medial flaring of the eyebrow (HP:0010747)3.06962123
15Abnormal mitochondria in muscle tissue (HP:0008316)3.05943238
16Progressive macrocephaly (HP:0004481)3.01362223
17Abnormal number of incisors (HP:0011064)3.00759370
18Colon cancer (HP:0003003)2.98289546
19Mitochondrial inheritance (HP:0001427)2.95905018
20Acute encephalopathy (HP:0006846)2.95253082
21Abnormality of midbrain morphology (HP:0002418)2.94951652
22Molar tooth sign on MRI (HP:0002419)2.94951652
23Abnormality of the 4th metacarpal (HP:0010012)2.90690176
24Pendular nystagmus (HP:0012043)2.77672151
25Abnormality of the labia minora (HP:0012880)2.76930843
26Rib fusion (HP:0000902)2.75446185
27Hepatocellular necrosis (HP:0001404)2.65691944
28Gait imbalance (HP:0002141)2.64943309
29Increased circulating renin level (HP:0000848)2.63073389
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.61966427
31Polyphagia (HP:0002591)2.61122557
32Increased nuchal translucency (HP:0010880)2.58637929
33Increased CSF lactate (HP:0002490)2.58561173
34Abnormality of the aortic arch (HP:0012303)2.57759473
35Hepatic necrosis (HP:0002605)2.57632837
36Intestinal atresia (HP:0011100)2.56523643
37Abnormality of abdominal situs (HP:0011620)2.53633006
38Abdominal situs inversus (HP:0003363)2.53633006
39Atresia of the external auditory canal (HP:0000413)2.50030911
40Limb dystonia (HP:0002451)2.49902044
41Abnormality of the renal medulla (HP:0100957)2.49032749
42Congenital stationary night blindness (HP:0007642)2.45151910
43High anterior hairline (HP:0009890)2.44467001
44Decreased circulating renin level (HP:0003351)2.43752724
45Type II lissencephaly (HP:0007260)2.43618863
46Abolished electroretinogram (ERG) (HP:0000550)2.43337038
47Abnormal lung lobation (HP:0002101)2.43000388
48Congenital primary aphakia (HP:0007707)2.42424350
49Supernumerary spleens (HP:0009799)2.40204756
50Retinal dysplasia (HP:0007973)2.37542354
51Astrocytoma (HP:0009592)2.37501810
52Abnormality of the astrocytes (HP:0100707)2.37501810
53Degeneration of anterior horn cells (HP:0002398)2.36674558
54Abnormality of the anterior horn cell (HP:0006802)2.36674558
55Bilateral microphthalmos (HP:0007633)2.33580721
56Oligodactyly (hands) (HP:0001180)2.33388713
57Abnormality of the ileum (HP:0001549)2.32960478
58Meckel diverticulum (HP:0002245)2.32823788
59Trismus (HP:0000211)2.29612519
60Breast hypoplasia (HP:0003187)2.28414485
61Nephrogenic diabetes insipidus (HP:0009806)2.27357742
62Hyperacusis (HP:0010780)2.20902933
63Hemiparesis (HP:0001269)2.20403184
64Trigonocephaly (HP:0000243)2.17770653
65Lissencephaly (HP:0001339)2.17218028
66Absent radius (HP:0003974)2.16313484
67Proximal placement of thumb (HP:0009623)2.15233533
68Oral leukoplakia (HP:0002745)2.14895628
69Optic nerve hypoplasia (HP:0000609)2.13053841
70Sclerocornea (HP:0000647)2.12797561
71Shawl scrotum (HP:0000049)2.12792233
72Genital tract atresia (HP:0001827)2.12340555
73Cystic liver disease (HP:0006706)2.11501522
74Pachygyria (HP:0001302)2.11342988
75Birth length less than 3rd percentile (HP:0003561)2.10966650
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09678605
77Shallow orbits (HP:0000586)2.09044592
78Short 5th finger (HP:0009237)2.07982997
79Aplasia involving forearm bones (HP:0009822)2.07912311
80Absent forearm bone (HP:0003953)2.07912311
81Broad toe (HP:0001837)2.06609926
82Deviation of the thumb (HP:0009603)2.06461836
83Neoplasm of striated muscle (HP:0009728)2.06016678
84Myokymia (HP:0002411)2.04925287
85Focal motor seizures (HP:0011153)2.03772759
86Increased corneal curvature (HP:0100692)2.03767980
87Keratoconus (HP:0000563)2.03767980
88Hepatoblastoma (HP:0002884)2.03674986
89Preauricular skin tag (HP:0000384)2.03047514
90Broad thumb (HP:0011304)2.01457405
91Vaginal atresia (HP:0000148)2.00239171
92Anophthalmia (HP:0000528)2.00086316
93Hyperglycinemia (HP:0002154)2.00069915
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.98766107
953-Methylglutaconic aciduria (HP:0003535)1.97774823
96Anencephaly (HP:0002323)1.97528171
97Glioma (HP:0009733)1.97251570
98Missing ribs (HP:0000921)1.96921278
99Aplasia/hypoplasia of the humerus (HP:0006507)1.96674886
100Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96216643
101Thyroid-stimulating hormone excess (HP:0002925)1.94682249
102Cerebral edema (HP:0002181)1.94599450
103Agitation (HP:0000713)1.94124170
104Broad alveolar ridges (HP:0000187)1.93427992
105Abnormality of the parathyroid morphology (HP:0011766)1.93331907
106Nephroblastoma (Wilms tumor) (HP:0002667)1.93244330
107Embryonal renal neoplasm (HP:0011794)1.92385909
108Abnormal respiratory motile cilium morphology (HP:0005938)1.91819523
109Abnormal respiratory epithelium morphology (HP:0012253)1.91819523
110Skin tags (HP:0010609)1.90977640
111Bifid tongue (HP:0010297)1.90193864
112Methylmalonic aciduria (HP:0012120)1.89958939
113Spina bifida occulta (HP:0003298)1.89703204
114Cerebellar dysplasia (HP:0007033)1.89519499
115Postaxial hand polydactyly (HP:0001162)1.89426805
116Rhabdomyosarcoma (HP:0002859)1.89014438
117Hypothermia (HP:0002045)1.88665552
118Methylmalonic acidemia (HP:0002912)1.88651874
119Ectopic kidney (HP:0000086)1.88629232
120Lipid accumulation in hepatocytes (HP:0006561)1.87408993
121Optic disc pallor (HP:0000543)1.86898125
122Tracheoesophageal fistula (HP:0002575)1.86632182
123Oligodactyly (HP:0012165)1.86607890
124Hyperglycinuria (HP:0003108)1.85878631
125Preaxial hand polydactyly (HP:0001177)1.85870605
126Failure to thrive in infancy (HP:0001531)1.85622071
127Chromsome breakage (HP:0040012)1.85111562
128Diastasis recti (HP:0001540)1.84539366
129Neoplasm of the pancreas (HP:0002894)1.84399823
130Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83270155
131Hemivertebrae (HP:0002937)1.82355560
132Supernumerary bones of the axial skeleton (HP:0009144)1.82219616
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.82045969
134Abnormality of the intervertebral disk (HP:0005108)1.81794973
135Specific learning disability (HP:0001328)1.81707139
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80978173
137Abnormal ciliary motility (HP:0012262)1.80465940
138Poor suck (HP:0002033)1.80463152
139Supernumerary ribs (HP:0005815)1.80455392
140Chronic hepatic failure (HP:0100626)1.80364210
141Small intestinal stenosis (HP:0012848)1.80181484
142Duodenal stenosis (HP:0100867)1.80181484
143Increased hepatocellular lipid droplets (HP:0006565)1.80094338
144Abnormality of the renal cortex (HP:0011035)1.80078743
145Optic nerve coloboma (HP:0000588)1.80049909
146Ketoacidosis (HP:0001993)1.78886565
147Carpal bone hypoplasia (HP:0001498)1.78676348
148Broad phalanges of the hand (HP:0009768)1.77977098
149Decreased central vision (HP:0007663)1.77173480
150Facial hemangioma (HP:0000329)1.76407886
151Abnormality of serine family amino acid metabolism (HP:0010894)1.75942502
152Abnormality of glycine metabolism (HP:0010895)1.75942502
153Abnormality of the lower motor neuron (HP:0002366)1.75134600
154Congenital diaphragmatic hernia (HP:0000776)1.75032432
155Postaxial foot polydactyly (HP:0001830)1.74928202
156Severe muscular hypotonia (HP:0006829)1.74566858
157Atrophy/Degeneration involving motor neurons (HP:0007373)1.74383994
158Male pseudohermaphroditism (HP:0000037)1.73820264
159Vertebral fusion (HP:0002948)1.73579593
160Facial cleft (HP:0002006)1.73456890
161Bicornuate uterus (HP:0000813)1.73062463
162Dynein arm defect of respiratory motile cilia (HP:0012255)1.72127263
163Absent/shortened dynein arms (HP:0200106)1.72127263
164Long eyelashes (HP:0000527)1.71650816
165Protrusio acetabuli (HP:0003179)1.71558238
166Congenital hepatic fibrosis (HP:0002612)1.70920022
167Triphalangeal thumb (HP:0001199)1.70397332
168Attenuation of retinal blood vessels (HP:0007843)1.69999916
169Focal seizures (HP:0007359)1.69631597
170Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69305710
171Short 1st metacarpal (HP:0010034)1.69305710
172Multiple enchondromatosis (HP:0005701)1.69165764
173Reticulocytopenia (HP:0001896)1.67778311
174Hypsarrhythmia (HP:0002521)1.66875701
175Broad finger (HP:0001500)1.66751966
176Abnormality of the duodenum (HP:0002246)1.66719495
177Poor coordination (HP:0002370)1.66516814
178Gastrointestinal atresia (HP:0002589)1.66165374
179Aganglionic megacolon (HP:0002251)1.65902196
180Renal hypoplasia (HP:0000089)1.65830314
181Absent thumb (HP:0009777)1.65078329
182Wide cranial sutures (HP:0010537)1.64332734
183Hyperventilation (HP:0002883)1.63759307
184Renovascular hypertension (HP:0100817)1.63459591
185Esotropia (HP:0000565)1.63357192
186Rectal fistula (HP:0100590)1.63078921
187Rectovaginal fistula (HP:0000143)1.63078921
188Short humerus (HP:0005792)1.62760905
189Preaxial foot polydactyly (HP:0001841)1.62270569
190Benign neoplasm of the central nervous system (HP:0100835)1.62188372
191Epileptiform EEG discharges (HP:0011182)1.62143218
192Horseshoe kidney (HP:0000085)1.61997294
193Esophageal atresia (HP:0002032)1.61329713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.79534833
2CDC73.58892729
3CASK3.36055803
4FRK3.00604719
5CDK122.86706783
6LATS22.77294063
7MAP3K42.67777033
8NEK12.67132589
9WEE12.59854580
10WNK32.50495864
11MAP4K22.49932541
12VRK22.44324408
13MAP2K72.43472283
14BMPR1B2.37407035
15MAPK132.29310359
16MAP3K102.29055898
17TTK2.16623178
18TESK22.12484330
19EPHB22.10497961
20GRK12.06415231
21CSNK1G32.06014820
22SRPK12.03405839
23NEK21.97259971
24MKNK11.95507856
25CSNK1G21.92805654
26TRIM281.89928648
27PINK11.88981025
28CDK71.88524218
29ZAK1.86121287
30PLK11.86047209
31TSSK61.85719201
32CSNK1A1L1.83894362
33PLK41.81003990
34CSNK1G11.78790436
35PAK41.76875886
36PASK1.76669274
37EIF2AK11.74385748
38ADRBK21.72013134
39TNIK1.56566531
40PLK31.56069725
41NUAK11.54024676
42CHEK21.53662448
43ACVR1B1.49919867
44PHKG21.46499403
45PHKG11.46499403
46TAOK31.45588204
47LIMK11.45239450
48TGFBR11.45040339
49BRSK11.44641952
50AURKA1.43270840
51ATR1.43072034
52ICK1.42177784
53STK38L1.38358681
54DYRK21.37964218
55PAK31.36336217
56RPS6KB21.35994061
57TLK11.33814639
58DYRK31.32967550
59AURKB1.30530343
60TESK11.28139478
61LATS11.27163108
62PRKCG1.25602192
63BRSK21.25497791
64CHEK11.22481970
65CCNB11.21391632
66EEF2K1.20465993
67KSR11.19689213
68MKNK21.18606082
69BRD41.18534060
70FGFR21.17132126
71PAK61.15618306
72EPHA41.11906972
73NTRK21.11454814
74NTRK31.03997927
75NME11.03285280
76DAPK21.02266348
77SIK31.00037598
78VRK10.99059719
79STK160.97874252
80WNK40.97844754
81TAF10.97252240
82MTOR0.95743826
83PRKCE0.92740051
84CDK40.92671672
85PKN10.92621180
86INSRR0.92539440
87CDK20.92522628
88FGFR10.92310177
89PNCK0.91314791
90MAP3K80.91066891
91UHMK10.88714449
92MAPKAPK50.87687754
93EIF2AK30.86992292
94MAP2K60.86990744
95TAOK20.85361108
96CDK80.81319689
97MINK10.79804916
98EPHA20.79358487
99PAK10.79321812
100PKN20.78145429
101PDGFRA0.77742051
102TYRO30.77627173
103TRIB30.77417136
104BCR0.76130514
105RPS6KA40.75449306
106CDK10.75215786
107CSNK1A10.74837531
108ERBB30.74402793
109ATM0.73087998
110ALK0.71745022
111MAP3K110.71093819
112ERBB20.70940519
113AKT20.70374944
114DYRK1A0.69283522
115ILK0.68097668
116GRK50.66521939
117DDR20.65986047
118BCKDK0.65469479
119EPHA30.64987352
120MAP2K40.61811574
121MARK10.61492222
122PTK2B0.60889838
123CSNK1D0.60825042
124BRAF0.60818323
125RPS6KA50.60765204
126STK100.59439847
127LMTK20.59418152
128MELK0.59186986
129CDK50.57994549
130CDK180.56385176
131MAPKAPK30.56311036
132TIE10.55693551
133CSNK1E0.55163444
134PRKCI0.54620236
135CAMK2A0.54355366
136CAMK10.54288945
137MAPK150.53741735
138CSNK2A10.52426623
139PRKCZ0.51685741
140PRKD30.51417611
141CDK90.50593267
142CDK140.50298871
143STK390.50262281
144CDK11A0.49936084
145CDK150.49121095
146OXSR10.48675783
147TNK20.48554688
148PRKACA0.48466999
149CDK60.48388048
150DYRK1B0.47944189
151ADRBK10.47929765
152CSNK2A20.47665144
153TTN0.47018689
154CDC42BPA0.46883583
155PRKAA10.45931968
156PTK20.45503689
157CAMK1G0.43452041
158STK40.43444725
159SCYL20.42756414
160PIM20.42464889
161SGK2230.41748630
162SGK4940.41748630
163RPS6KA10.40550353
164DAPK10.39584031
165AKT30.39364352
166STK110.37023075
167EIF2AK20.36823045
168FER0.36627903
169AKT10.35863482
170PLK20.35426481
171MAPK90.34468772
172PRKDC0.31090168

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51101589
2Mismatch repair_Homo sapiens_hsa034304.03079211
3Spliceosome_Homo sapiens_hsa030403.76345198
4RNA transport_Homo sapiens_hsa030133.24457934
5Base excision repair_Homo sapiens_hsa034103.12151168
6Cell cycle_Homo sapiens_hsa041103.03207244
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98786234
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69491089
9Homologous recombination_Homo sapiens_hsa034402.63145995
10One carbon pool by folate_Homo sapiens_hsa006702.62381351
11RNA polymerase_Homo sapiens_hsa030202.60403211
12Proteasome_Homo sapiens_hsa030502.56048198
13Ribosome_Homo sapiens_hsa030102.55918834
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47742813
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47584023
16Basal cell carcinoma_Homo sapiens_hsa052172.46534340
17Nicotine addiction_Homo sapiens_hsa050332.45483060
18Nucleotide excision repair_Homo sapiens_hsa034202.39755633
19mRNA surveillance pathway_Homo sapiens_hsa030152.27436683
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.25301541
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23489394
22Butanoate metabolism_Homo sapiens_hsa006502.13637841
23Phototransduction_Homo sapiens_hsa047442.13613134
24Protein export_Homo sapiens_hsa030602.00550707
25Pyrimidine metabolism_Homo sapiens_hsa002402.00535434
26Fanconi anemia pathway_Homo sapiens_hsa034601.91234496
27Hedgehog signaling pathway_Homo sapiens_hsa043401.88489971
28Hippo signaling pathway_Homo sapiens_hsa043901.79052518
29RNA degradation_Homo sapiens_hsa030181.78120303
30Alzheimers disease_Homo sapiens_hsa050101.69940921
31GABAergic synapse_Homo sapiens_hsa047271.58362729
32Steroid biosynthesis_Homo sapiens_hsa001001.55871349
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55035416
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54671512
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51608000
36Morphine addiction_Homo sapiens_hsa050321.49443309
37Collecting duct acid secretion_Homo sapiens_hsa049661.48803494
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47027890
39Basal transcription factors_Homo sapiens_hsa030221.45398410
40Fatty acid elongation_Homo sapiens_hsa000621.41298233
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39474477
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39201780
43p53 signaling pathway_Homo sapiens_hsa041151.39058974
44Biosynthesis of amino acids_Homo sapiens_hsa012301.38430357
45Nitrogen metabolism_Homo sapiens_hsa009101.37910661
46Insulin secretion_Homo sapiens_hsa049111.37064103
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35318561
48Notch signaling pathway_Homo sapiens_hsa043301.34259703
49Oocyte meiosis_Homo sapiens_hsa041141.33226714
50Propanoate metabolism_Homo sapiens_hsa006401.31934128
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28638262
52Peroxisome_Homo sapiens_hsa041461.25780947
53Non-homologous end-joining_Homo sapiens_hsa034501.22857591
54Circadian entrainment_Homo sapiens_hsa047131.22012930
55Synaptic vesicle cycle_Homo sapiens_hsa047211.20654264
56Tryptophan metabolism_Homo sapiens_hsa003801.18899967
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15402517
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14925731
59Cocaine addiction_Homo sapiens_hsa050301.13923064
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13844452
61Sulfur metabolism_Homo sapiens_hsa009201.12443747
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12431421
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12002850
64Taste transduction_Homo sapiens_hsa047421.10823431
65MicroRNAs in cancer_Homo sapiens_hsa052061.08635036
66Dopaminergic synapse_Homo sapiens_hsa047281.05422078
67Wnt signaling pathway_Homo sapiens_hsa043101.05279200
68Epstein-Barr virus infection_Homo sapiens_hsa051691.05152620
69TGF-beta signaling pathway_Homo sapiens_hsa043501.05119420
70Glutamatergic synapse_Homo sapiens_hsa047241.04644057
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04552670
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03798755
73beta-Alanine metabolism_Homo sapiens_hsa004101.02766419
74Adherens junction_Homo sapiens_hsa045201.02541465
75Linoleic acid metabolism_Homo sapiens_hsa005910.98234964
76HTLV-I infection_Homo sapiens_hsa051660.98146439
77Serotonergic synapse_Homo sapiens_hsa047260.97192989
78Olfactory transduction_Homo sapiens_hsa047400.94787964
79Purine metabolism_Homo sapiens_hsa002300.93597042
80Thyroid cancer_Homo sapiens_hsa052160.93438655
81Carbon metabolism_Homo sapiens_hsa012000.90811577
82Colorectal cancer_Homo sapiens_hsa052100.89991795
83Ether lipid metabolism_Homo sapiens_hsa005650.89419306
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.89408724
85Bladder cancer_Homo sapiens_hsa052190.86853158
86Amphetamine addiction_Homo sapiens_hsa050310.86659840
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.85725134
88Lysine degradation_Homo sapiens_hsa003100.81844947
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79683956
90Viral carcinogenesis_Homo sapiens_hsa052030.74249077
91Huntingtons disease_Homo sapiens_hsa050160.73873321
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.73418478
93Metabolic pathways_Homo sapiens_hsa011000.72887015
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71470365
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.70539479
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69636280
97Fatty acid metabolism_Homo sapiens_hsa012120.65621319
98Pathways in cancer_Homo sapiens_hsa052000.65020545
99Tight junction_Homo sapiens_hsa045300.64880192
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63959353
101Vitamin B6 metabolism_Homo sapiens_hsa007500.62696266
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59876510
103Salivary secretion_Homo sapiens_hsa049700.59732959
104Endometrial cancer_Homo sapiens_hsa052130.58719840
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58617860
106Sulfur relay system_Homo sapiens_hsa041220.56899665
107Systemic lupus erythematosus_Homo sapiens_hsa053220.56812470
108Viral myocarditis_Homo sapiens_hsa054160.56272636
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55299588
110Melanogenesis_Homo sapiens_hsa049160.54959779
111Proteoglycans in cancer_Homo sapiens_hsa052050.54626653
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54538376
113Small cell lung cancer_Homo sapiens_hsa052220.54016536
114Parkinsons disease_Homo sapiens_hsa050120.53893816
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53719922
116Chemical carcinogenesis_Homo sapiens_hsa052040.52664967
117Calcium signaling pathway_Homo sapiens_hsa040200.51297036
118Regulation of autophagy_Homo sapiens_hsa041400.50336324
119Selenocompound metabolism_Homo sapiens_hsa004500.50331901
120Caffeine metabolism_Homo sapiens_hsa002320.49340325
121Herpes simplex infection_Homo sapiens_hsa051680.44775624
122mTOR signaling pathway_Homo sapiens_hsa041500.44740911
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43570299
124Chronic myeloid leukemia_Homo sapiens_hsa052200.43493283
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42967979
126Ovarian steroidogenesis_Homo sapiens_hsa049130.41762428
127Long-term depression_Homo sapiens_hsa047300.41736186
128Melanoma_Homo sapiens_hsa052180.41504534
129Fructose and mannose metabolism_Homo sapiens_hsa000510.40780117
130Axon guidance_Homo sapiens_hsa043600.40662649
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.40647502
132Cholinergic synapse_Homo sapiens_hsa047250.40299032
133ABC transporters_Homo sapiens_hsa020100.39857279
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39113658
135HIF-1 signaling pathway_Homo sapiens_hsa040660.39092559
136Renin secretion_Homo sapiens_hsa049240.37239542
137Alcoholism_Homo sapiens_hsa050340.37197347
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35335609
139Pentose phosphate pathway_Homo sapiens_hsa000300.34525532
140Pyruvate metabolism_Homo sapiens_hsa006200.34016742
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32669244
142Galactose metabolism_Homo sapiens_hsa000520.31876024
143N-Glycan biosynthesis_Homo sapiens_hsa005100.30602889
144Folate biosynthesis_Homo sapiens_hsa007900.30379060
145Arginine and proline metabolism_Homo sapiens_hsa003300.30189789
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29308721
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27990926
148Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27463826
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.26212534
150Cardiac muscle contraction_Homo sapiens_hsa042600.26159087
151Prostate cancer_Homo sapiens_hsa052150.25942260
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25216166
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24549685
154Glutathione metabolism_Homo sapiens_hsa004800.23760165
155Dilated cardiomyopathy_Homo sapiens_hsa054140.22198903
156Non-small cell lung cancer_Homo sapiens_hsa052230.22028756
157Gap junction_Homo sapiens_hsa045400.20791123
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20519221
159Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19098442
160Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18980466
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17198410
162Renal cell carcinoma_Homo sapiens_hsa052110.15918123
163Neurotrophin signaling pathway_Homo sapiens_hsa047220.15684813
164Oxidative phosphorylation_Homo sapiens_hsa001900.15426022

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