DCANP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.69783722
2neutrophil activation involved in immune response (GO:0002283)6.66960292
3B cell mediated immunity (GO:0019724)6.09325119
4positive regulation of mast cell degranulation (GO:0043306)5.26563599
5positive regulation of mast cell activation involved in immune response (GO:0033008)5.26563599
6interferon-gamma-mediated signaling pathway (GO:0060333)5.20463565
7regulation of hypersensitivity (GO:0002883)5.18942660
8positive regulation of mast cell activation (GO:0033005)5.08766886
9positive regulation of antigen processing and presentation (GO:0002579)4.81682312
10positive regulation of gamma-delta T cell activation (GO:0046645)4.80794717
11regulation of antigen processing and presentation (GO:0002577)4.27094689
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.25835160
13response to peptidoglycan (GO:0032494)4.23056105
14regulation of mast cell activation (GO:0033003)4.17923275
15positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.07655362
16cellular response to interferon-gamma (GO:0071346)4.02739425
17mast cell activation (GO:0045576)3.94745678
18myeloid cell activation involved in immune response (GO:0002275)3.94306694
19detection of bacterium (GO:0016045)3.93578753
20positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.93422967
21regulation of B cell receptor signaling pathway (GO:0050855)3.93058105
22regulation of mast cell degranulation (GO:0043304)3.92700095
23positive regulation of type 2 immune response (GO:0002830)3.89604730
24T cell costimulation (GO:0031295)3.88513145
25positive regulation of B cell differentiation (GO:0045579)3.87978368
26mature B cell differentiation involved in immune response (GO:0002313)3.87820153
27cellular extravasation (GO:0045123)3.86561665
28chaperone mediated protein folding requiring cofactor (GO:0051085)3.83274136
29lymphocyte costimulation (GO:0031294)3.83016669
30regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81596679
31neutrophil activation (GO:0042119)3.81350406
32purine deoxyribonucleotide catabolic process (GO:0009155)3.77727312
33positive thymic T cell selection (GO:0045059)3.75173492
34detection of other organism (GO:0098543)3.73509824
35regulation of mast cell activation involved in immune response (GO:0033006)3.68492927
36negative regulation of B cell apoptotic process (GO:0002903)3.67365826
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.65232297
38regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.59372834
39response to interferon-gamma (GO:0034341)3.58407732
40macrophage activation involved in immune response (GO:0002281)3.54020421
41negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.53534352
42regulation of B cell differentiation (GO:0045577)3.52717908
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.51055189
44antigen processing and presentation of endogenous antigen (GO:0019883)3.47015734
45granulocyte activation (GO:0036230)3.45116204
46regulation of inflammatory response to antigenic stimulus (GO:0002861)3.43092828
47positive regulation of leukocyte degranulation (GO:0043302)3.42393621
48cell wall macromolecule catabolic process (GO:0016998)3.40843992
49negative regulation of interleukin-12 production (GO:0032695)3.37346939
50detection of external biotic stimulus (GO:0098581)3.34797525
51modulation of growth of symbiont involved in interaction with host (GO:0044144)3.31793337
52regulation of growth of symbiont in host (GO:0044126)3.31793337
53negative regulation of growth of symbiont in host (GO:0044130)3.31793337
54negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.31793337
55positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.31607151
56purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.29094161
57regulation of gamma-delta T cell activation (GO:0046643)3.28658486
58regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.28003576
59regulation of leukocyte degranulation (GO:0043300)3.26561103
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24657365
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24657365
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.24657365
63modulation by symbiont of host immune response (GO:0052553)3.24657365
64positive regulation by symbiont of host defense response (GO:0052509)3.24657365
65modulation by symbiont of host defense response (GO:0052031)3.24657365
66defense response to protozoan (GO:0042832)3.23464393
67regulation of T cell tolerance induction (GO:0002664)3.21365159
68microglial cell activation (GO:0001774)3.18807471
69regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.17581692
70positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.16884662
71NAD biosynthetic process (GO:0009435)3.16575914
72mature B cell differentiation (GO:0002335)3.16092831
73regulation of tolerance induction (GO:0002643)3.15062331
74respiratory burst (GO:0045730)3.14499805
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13013485
76response to protozoan (GO:0001562)3.07740973
77production of molecular mediator of immune response (GO:0002440)3.05453551
78detection of biotic stimulus (GO:0009595)3.04977960
79leukocyte degranulation (GO:0043299)3.04132302
80positive regulation of macrophage cytokine production (GO:0060907)3.03971623
81T cell activation involved in immune response (GO:0002286)3.01383427
82G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.00290361
83regulation of T-helper 2 cell differentiation (GO:0045628)2.99212481
84mast cell activation involved in immune response (GO:0002279)2.98429058
85mast cell degranulation (GO:0043303)2.98429058
86B cell receptor signaling pathway (GO:0050853)2.97462382
87cellular response to exogenous dsRNA (GO:0071360)2.97279247
88T-helper 1 type immune response (GO:0042088)2.97042103
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95871995
90response to hydroperoxide (GO:0033194)2.95642436
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93637308
92regulation of type 2 immune response (GO:0002828)2.92605778
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92327951
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91569944
95response to host immune response (GO:0052572)2.91569944
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91364983
97myeloid dendritic cell activation (GO:0001773)2.89801068
98antigen receptor-mediated signaling pathway (GO:0050851)2.88265919
99peptide catabolic process (GO:0043171)2.85875890
100positive regulation of interferon-gamma production (GO:0032729)2.85807460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.56509833
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.78443739
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.53482037
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.22055674
5VDR_21846776_ChIP-Seq_THP-1_Human3.42127781
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.41893589
7SCL_19346495_ChIP-Seq_HPC-7_Human3.35145737
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28743619
9SPI1_23547873_ChIP-Seq_NB4_Human3.13989889
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06953828
11VDR_24763502_ChIP-Seq_THP-1_Human3.05590961
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93080346
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.82142553
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62116050
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55005038
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48689320
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35543521
18MYB_26560356_Chip-Seq_TH2_Human2.32613618
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32272380
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27294407
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24249434
22SPI1_23127762_ChIP-Seq_K562_Human2.23823680
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15068444
24CIITA_25753668_ChIP-Seq_RAJI_Human2.14219289
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08014987
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.04914724
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01362562
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98023860
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96080956
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94356190
31VDR_24787735_ChIP-Seq_THP-1_Human1.93523524
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.90674431
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79975923
34RUNX_20019798_ChIP-Seq_JUKART_Human1.79744019
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78703464
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77046559
37MYB_26560356_Chip-Seq_TH1_Human1.73002245
38MAF_26560356_Chip-Seq_TH1_Human1.71423140
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70765481
40UTX_26944678_Chip-Seq_JUKART_Human1.68637805
41GATA3_27048872_Chip-Seq_THYMUS_Human1.64614778
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61283359
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56090441
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51192013
45MYC_22102868_ChIP-Seq_BL_Human1.46422407
46GATA3_26560356_Chip-Seq_TH2_Human1.44987727
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42748166
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34447007
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33905014
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32418928
51SPI1_20517297_ChIP-Seq_HL60_Human1.29862673
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27268836
53MAF_26560356_Chip-Seq_TH2_Human1.23649954
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22659712
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21272085
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18686112
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18070781
58BCL6_27268052_Chip-Seq_Bcells_Human1.17813998
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15909889
60FOXP3_21729870_ChIP-Seq_TREG_Human1.13982524
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11735649
62PU_27001747_Chip-Seq_BMDM_Mouse1.11430379
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09887572
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09740097
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.08566876
66VDR_23849224_ChIP-Seq_CD4+_Human1.08283424
67GATA1_22025678_ChIP-Seq_K562_Human1.07335339
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05758397
69TFEB_21752829_ChIP-Seq_HELA_Human1.05517052
70STAT1_20625510_ChIP-Seq_HELA_Human1.03296894
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02113918
72SMRT_27268052_Chip-Seq_Bcells_Human1.00065238
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00010519
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99775705
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99096960
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98967715
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97265530
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95305416
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94612731
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94021316
81PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93260599
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92887665
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92342069
84EGR1_19032775_ChIP-ChIP_M12_Human0.91835953
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.90824610
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90162408
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89942753
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88127000
89P300_27268052_Chip-Seq_Bcells_Human0.87596324
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87395535
91TAF2_19829295_ChIP-Seq_ESCs_Human0.86413907
92GATA3_26560356_Chip-Seq_TH1_Human0.85367969
93E2F1_20622854_ChIP-Seq_HELA_Human0.84697708
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81432895
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81151436
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78987631
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77939367
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77895341
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76898993
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74030164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.12785733
2MP0002396_abnormal_hematopoietic_system3.25557083
3MP0005451_abnormal_body_composition3.17799087
4MP0005671_abnormal_response_to3.15449744
5MP0001800_abnormal_humoral_immune3.07400168
6MP0002419_abnormal_innate_immunity3.02556535
7MP0002148_abnormal_hypersensitivity_rea2.91587838
8MP0009785_altered_susceptibility_to2.82749402
9MP0005000_abnormal_immune_tolerance2.82666902
10MP0005025_abnormal_response_to2.76169197
11MP0003436_decreased_susceptibility_to2.75802709
12MP0002452_abnormal_antigen_presenting2.66057899
13MP0002723_abnormal_immune_serum2.65232776
14MP0001790_abnormal_immune_system2.42990367
15MP0005387_immune_system_phenotype2.42990367
16MP0002420_abnormal_adaptive_immunity2.42018207
17MP0001819_abnormal_immune_cell2.40125379
18MP0005464_abnormal_platelet_physiology2.35334616
19MP0006082_CNS_inflammation2.28077140
20MP0003724_increased_susceptibility_to2.20712439
21MP0009764_decreased_sensitivity_to2.08223292
22MP0003172_abnormal_lysosome_physiology2.00582284
23MP0005397_hematopoietic_system_phenotyp1.91929831
24MP0001545_abnormal_hematopoietic_system1.91929831
25MP0002398_abnormal_bone_marrow1.91328499
26MP0005058_abnormal_lysosome_morphology1.91213242
27MP0002166_altered_tumor_susceptibility1.88791621
28MP0000716_abnormal_immune_system1.85465439
29MP0003075_altered_response_to1.78426852
30MP0010155_abnormal_intestine_physiology1.77401261
31MP0009278_abnormal_bone_marrow1.77275225
32MP0005075_abnormal_melanosome_morpholog1.75560314
33MP0000685_abnormal_immune_system1.75388625
34MP0003806_abnormal_nucleotide_metabolis1.71359463
35MP0003303_peritoneal_inflammation1.64226312
36MP0003866_abnormal_defecation1.61554736
37MP0001845_abnormal_inflammatory_respons1.61374358
38MP0008469_abnormal_protein_level1.60624556
39MP0001853_heart_inflammation1.59574039
40MP0000689_abnormal_spleen_morphology1.58122037
41MP0002405_respiratory_system_inflammati1.55914008
42MP0002429_abnormal_blood_cell1.53777816
43MP0003300_gastrointestinal_ulcer1.48164783
44MP0000858_altered_metastatic_potential1.46825607
45MP0005166_decreased_susceptibility_to1.45018355
46MP0002722_abnormal_immune_system1.34953471
47MP0000343_altered_response_to1.30418108
48MP0003828_pulmonary_edema1.29433314
49MP0001986_abnormal_taste_sensitivity1.28151191
50MP0003763_abnormal_thymus_physiology1.26897075
51MP0009333_abnormal_splenocyte_physiolog1.25855787
52MP0001533_abnormal_skeleton_physiology1.23741279
53MP0002006_tumorigenesis1.21248311
54MP0001542_abnormal_bone_strength1.19705949
55MP0002998_abnormal_bone_remodeling1.15605277
56MP0005165_increased_susceptibility_to1.08572449
57MP0000015_abnormal_ear_pigmentation1.07595806
58MP0004883_abnormal_blood_vessel1.06527706
59MP0005174_abnormal_tail_pigmentation1.00017080
60MP0008057_abnormal_DNA_replication0.98839857
61MP0009763_increased_sensitivity_to0.97728731
62MP0000703_abnormal_thymus_morphology0.97144310
63MP0002009_preneoplasia0.97074820
64MP0009115_abnormal_fat_cell0.96999337
65MP0004808_abnormal_hematopoietic_stem0.93206318
66MP0002822_catalepsy0.91200292
67MP0003656_abnormal_erythrocyte_physiolo0.89240045
68MP0004084_abnormal_cardiac_muscle0.89006418
69MP0003183_abnormal_peptide_metabolism0.87454422
70MP0000465_gastrointestinal_hemorrhage0.86968038
71MP0006036_abnormal_mitochondrial_physio0.86737980
72MP0002019_abnormal_tumor_incidence0.83055115
73MP0004947_skin_inflammation0.82229432
74MP0000249_abnormal_blood_vessel0.78807138
75MP0000371_diluted_coat_color0.78111378
76MP0001873_stomach_inflammation0.77671947
77MP0005535_abnormal_body_temperature0.72830609
78MP0005319_abnormal_enzyme/_coenzyme0.71379002
79MP0003186_abnormal_redox_activity0.70360329
80MP0005164_abnormal_response_to0.68521027
81MP0008007_abnormal_cellular_replicative0.68126726
82MP0009379_abnormal_foot_pigmentation0.67150381
83MP0002876_abnormal_thyroid_physiology0.66822506
84MP0003448_altered_tumor_morphology0.66361961
85MP0004381_abnormal_hair_follicle0.65063126
86MP0005645_abnormal_hypothalamus_physiol0.64982291
87MP0008875_abnormal_xenobiotic_pharmacok0.64267198
88MP0001663_abnormal_digestive_system0.63759411
89MP0000490_abnormal_crypts_of0.62895781
90MP0000569_abnormal_digit_pigmentation0.62373961
91MP0002837_dystrophic_cardiac_calcinosis0.62103227
92MP0005584_abnormal_enzyme/coenzyme_acti0.59819126
93MP0002877_abnormal_melanocyte_morpholog0.56872183
94MP0008873_increased_physiological_sensi0.56779632
95MP0005647_abnormal_sex_gland0.56685520
96MP0002132_abnormal_respiratory_system0.56387363
97MP0003045_fibrosis0.56119992
98MP0006072_abnormal_retinal_apoptosis0.55876346
99MP0000920_abnormal_myelination0.52577643
100MP0005334_abnormal_fat_pad0.51060296

Predicted human phenotypes

RankGene SetZ-score
1Chronic obstructive pulmonary disease (HP:0006510)5.18562342
2Obstructive lung disease (HP:0006536)5.18562342
3Recurrent gram-negative bacterial infections (HP:0005420)4.70058591
4Recurrent abscess formation (HP:0002722)4.65988488
5Amyloidosis (HP:0011034)4.42309724
6Abnormality of the prostate (HP:0008775)4.33787759
7Panhypogammaglobulinemia (HP:0003139)4.31676636
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.20728660
9Meningitis (HP:0001287)4.07371087
10Recurrent bacterial skin infections (HP:0005406)4.04525117
11Chronic mucocutaneous candidiasis (HP:0002728)4.00912916
12Recurrent cutaneous fungal infections (HP:0011370)4.00912916
13Chest pain (HP:0100749)3.93414758
14Increased cerebral lipofuscin (HP:0011813)3.89856133
15Recurrent fungal infections (HP:0002841)3.78997391
16Mediastinal lymphadenopathy (HP:0100721)3.65355442
17Hemoptysis (HP:0002105)3.62686278
18Pulmonary infiltrates (HP:0002113)3.60527662
19Elevated erythrocyte sedimentation rate (HP:0003565)3.57010177
20Ureteral stenosis (HP:0000071)3.52356104
21Ureteral obstruction (HP:0006000)3.41403981
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.32366571
23Eczematoid dermatitis (HP:0000976)3.30327575
24Recurrent skin infections (HP:0001581)3.29512271
25Abnormality of macrophages (HP:0004311)3.25369885
26Vasculitis (HP:0002633)3.21293377
27Urticaria (HP:0001025)3.06289527
28Agammaglobulinemia (HP:0004432)3.01087219
29Stomatitis (HP:0010280)3.01037283
30Abnormality of the pleura (HP:0002103)2.95627287
31Colitis (HP:0002583)2.95259491
32Epistaxis (HP:0000421)2.93745258
33Pulmonary embolism (HP:0002204)2.89150589
34Acute lymphatic leukemia (HP:0006721)2.84439851
35Macular degeneration (HP:0000608)2.82179851
36Recurrent viral infections (HP:0004429)2.78743298
37Basal ganglia calcification (HP:0002135)2.75514944
38Polygenic inheritance (HP:0010982)2.75113558
39Chronic sinusitis (HP:0011109)2.74827185
40B lymphocytopenia (HP:0010976)2.71479561
41Vacuolated lymphocytes (HP:0001922)2.67742434
42Abnormality of male internal genitalia (HP:0000022)2.66240459
43Fatigue (HP:0012378)2.62815192
44Gangrene (HP:0100758)2.62360544
45Thrombocytosis (HP:0001894)2.62325503
46Spondylolisthesis (HP:0003302)2.61427251
47Inflammation of the large intestine (HP:0002037)2.61005115
48Granulocytopenia (HP:0001913)2.59130461
49Abnormality of B cell number (HP:0010975)2.57435686
50Spontaneous hematomas (HP:0007420)2.53458478
51Gastrointestinal infarctions (HP:0005244)2.49815871
52Pulmonary fibrosis (HP:0002206)2.48670531
53Exertional dyspnea (HP:0002875)2.45015875
54Skin rash (HP:0000988)2.41394746
55Gastrointestinal inflammation (HP:0004386)2.39972843
56Encephalitis (HP:0002383)2.39883109
57Abolished electroretinogram (ERG) (HP:0000550)2.38224359
58Petechiae (HP:0000967)2.37780791
59Gingival bleeding (HP:0000225)2.37732078
60Porencephaly (HP:0002132)2.34001043
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32992745
62Thrombophlebitis (HP:0004418)2.32471942
63Hepatocellular necrosis (HP:0001404)2.30962825
64Hypoplasia of the thymus (HP:0000778)2.29447515
65Acute myeloid leukemia (HP:0004808)2.23043031
66Xerostomia (HP:0000217)2.22910701
67Myositis (HP:0100614)2.22101694
68Severe combined immunodeficiency (HP:0004430)2.22073058
69Cone-rod dystrophy (HP:0000548)2.19866812
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.19148175
71Absent/shortened dynein arms (HP:0200106)2.19148175
72Gingivitis (HP:0000230)2.18607479
73Recurrent bronchitis (HP:0002837)2.17296636
74Purpura (HP:0000979)2.16217610
75Progressive visual loss (HP:0000529)2.13628843
76Polyneuropathy (HP:0001271)2.13270168
77Mutism (HP:0002300)2.12544592
78Abnormality of glycolipid metabolism (HP:0010969)2.12252362
79Abnormality of liposaccharide metabolism (HP:0010968)2.12252362
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.12252362
81Restrictive lung disease (HP:0002091)2.11718997
82Metaphyseal dysplasia (HP:0100255)2.05808715
83Leukocytosis (HP:0001974)2.02968841
84Alveolar cell carcinoma (HP:0006519)2.02326557
85Systemic lupus erythematosus (HP:0002725)2.00285349
86Neoplasm of the tracheobronchial system (HP:0100552)1.98546707
87Abnormality of T cells (HP:0002843)1.98539955
88Cerebral ischemia (HP:0002637)1.97153727
89Abnormality of the pericardium (HP:0001697)1.96577295
90Abnormality of T cell physiology (HP:0011840)1.95987845
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95386406
92Hypertensive crisis (HP:0100735)1.93458935
93Glomerulopathy (HP:0100820)1.93320945
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.92985184
95Cerebral hemorrhage (HP:0001342)1.89488906
96Arterial thrombosis (HP:0004420)1.89108580
97Mitochondrial inheritance (HP:0001427)1.88925180
98Dysostosis multiplex (HP:0000943)1.88776621
99T lymphocytopenia (HP:0005403)1.87261680
100Osteomyelitis (HP:0002754)1.85711132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR25.07312489
2RIPK44.55777180
3MAP4K14.08330272
4KIT4.03642984
5CSF1R3.79037893
6CDK193.55085458
7FLT33.29510417
8PIK3CG2.93966942
9TYK22.48425200
10BLK2.37159835
11TEC2.04347583
12SYK2.03876750
13TXK1.89617979
14FES1.81177639
15JAK31.73149661
16IRAK41.65407163
17ZAP701.64380575
18LYN1.58709981
19BTK1.58593241
20IKBKB1.56494791
21NME21.46834227
22MAP3K121.45323088
23TLK11.44653742
24KDR1.42298951
25HCK1.33676619
26RPS6KA41.29234187
27TNK21.28005367
28MAP2K31.24436102
29MAP3K111.21258736
30MAP3K61.19284311
31LCK1.16703505
32ITK1.15476684
33GRK71.12294965
34CDK41.11468609
35TRPM71.10873087
36TESK21.00461647
37ERN10.98583369
38TBK10.97015887
39JAK10.94597323
40MATK0.89636736
41GRK60.83918504
42CSK0.82608690
43CDK60.80814622
44BRD40.79824230
45JAK20.77853251
46OXSR10.76634145
47ILK0.76002275
48IKBKE0.73576014
49CDK120.73444258
50ABL10.69462664
51CDC42BPA0.65741277
52MAP3K140.65682973
53MOS0.60820053
54MAP3K50.60523393
55MAP3K130.59024483
56PDK10.56692587
57PIM20.56595684
58ABL20.55860158
59MAP2K40.55720842
60PKN10.55375792
61MAPK70.51849482
62ERBB30.48096301
63EGFR0.47899710
64DAPK10.46585744
65PRKCD0.45715941
66ATR0.45714499
67IGF1R0.42912802
68TAOK30.42572500
69MAPK120.41976637
70CDK30.41778313
71MARK30.41350048
72MAP3K10.40159413
73PIM10.39894017
74DAPK30.39365233
75PDPK10.39054664
76MAP3K70.37345687
77CSNK1G30.37138397
78ADRBK20.36906797
79PTK2B0.36752954
80CDK90.35969265
81PRKD10.34953153
82PRKCQ0.33973782
83MARK20.33959148
84GRK10.32655333
85INSRR0.32561649
86NEK20.31687789
87VRK20.31598929
88CSNK1A1L0.31593750
89MST40.31237014
90MAPK40.31236996
91PRKG10.31149715
92TGFBR20.31069482
93CAMK10.29782620
94MAP3K30.29376041
95DYRK1B0.29371230
96MAP2K20.28795453
97STK240.28528599
98EIF2AK30.28239934
99RPS6KA50.27805730
100FYN0.27326866

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.33574286
2Allograft rejection_Homo sapiens_hsa053305.05251207
3Graft-versus-host disease_Homo sapiens_hsa053324.84392042
4Autoimmune thyroid disease_Homo sapiens_hsa053204.75915387
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.21315585
6Type I diabetes mellitus_Homo sapiens_hsa049404.14240720
7Staphylococcus aureus infection_Homo sapiens_hsa051503.54030785
8Leishmaniasis_Homo sapiens_hsa051403.25678638
9Viral myocarditis_Homo sapiens_hsa054163.12074684
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.86117829
11Antigen processing and presentation_Homo sapiens_hsa046122.82069334
12Rheumatoid arthritis_Homo sapiens_hsa053232.43570454
13Hematopoietic cell lineage_Homo sapiens_hsa046402.24509588
14Tuberculosis_Homo sapiens_hsa051521.91779612
15Toxoplasmosis_Homo sapiens_hsa051451.71582862
16Influenza A_Homo sapiens_hsa051641.55818987
17Herpes simplex infection_Homo sapiens_hsa051681.46677201
18Phagosome_Homo sapiens_hsa041451.33070582
19Primary immunodeficiency_Homo sapiens_hsa053401.32606508
20Osteoclast differentiation_Homo sapiens_hsa043801.18895795
21Systemic lupus erythematosus_Homo sapiens_hsa053221.17411065
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10859319
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98378507
24B cell receptor signaling pathway_Homo sapiens_hsa046620.97090543
25Pertussis_Homo sapiens_hsa051330.93627685
26NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87406541
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82403995
28Oxidative phosphorylation_Homo sapiens_hsa001900.82312182
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81690679
30Epstein-Barr virus infection_Homo sapiens_hsa051690.77367345
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74164891
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68734700
33NF-kappa B signaling pathway_Homo sapiens_hsa040640.67733103
34SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65362861
35Lysosome_Homo sapiens_hsa041420.61532162
36Other glycan degradation_Homo sapiens_hsa005110.58033617
37Legionellosis_Homo sapiens_hsa051340.57594779
38Platelet activation_Homo sapiens_hsa046110.54877205
39Ribosome_Homo sapiens_hsa030100.52829261
40Homologous recombination_Homo sapiens_hsa034400.51107848
41Measles_Homo sapiens_hsa051620.49758296
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49663019
43Salmonella infection_Homo sapiens_hsa051320.49302150
44Non-homologous end-joining_Homo sapiens_hsa034500.47573910
45DNA replication_Homo sapiens_hsa030300.44961273
46Parkinsons disease_Homo sapiens_hsa050120.43331941
47Acute myeloid leukemia_Homo sapiens_hsa052210.43012807
48HTLV-I infection_Homo sapiens_hsa051660.39518936
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38441530
50Chemokine signaling pathway_Homo sapiens_hsa040620.36978003
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.35313765
52Shigellosis_Homo sapiens_hsa051310.34552796
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33700288
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.33513375
55T cell receptor signaling pathway_Homo sapiens_hsa046600.33169049
56Malaria_Homo sapiens_hsa051440.31800730
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.31332348
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27412332
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.27136485
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26954929
61Arachidonic acid metabolism_Homo sapiens_hsa005900.26157442
62Huntingtons disease_Homo sapiens_hsa050160.26118005
63Alzheimers disease_Homo sapiens_hsa050100.24547450
64Sulfur metabolism_Homo sapiens_hsa009200.23632637
65Collecting duct acid secretion_Homo sapiens_hsa049660.22766719
66TNF signaling pathway_Homo sapiens_hsa046680.22260651
67Phototransduction_Homo sapiens_hsa047440.21896208
68African trypanosomiasis_Homo sapiens_hsa051430.21721272
69Proteasome_Homo sapiens_hsa030500.20748710
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20148587
71Renin-angiotensin system_Homo sapiens_hsa046140.17236576
72Salivary secretion_Homo sapiens_hsa049700.15511390
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13827085
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13524018
75Cardiac muscle contraction_Homo sapiens_hsa042600.13326915
76Hepatitis B_Homo sapiens_hsa051610.12860682
77Ether lipid metabolism_Homo sapiens_hsa005650.12068876
78Non-small cell lung cancer_Homo sapiens_hsa052230.11785430
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10886839
80Linoleic acid metabolism_Homo sapiens_hsa005910.10490995
81Hepatitis C_Homo sapiens_hsa051600.10166378
82Tryptophan metabolism_Homo sapiens_hsa003800.09667002
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09610592
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.09209589
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.08052851
86Sphingolipid metabolism_Homo sapiens_hsa006000.06775254
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06014419
88Fanconi anemia pathway_Homo sapiens_hsa034600.04816316
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.03315361
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02670594
91Base excision repair_Homo sapiens_hsa034100.02482695
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.01959990
93Regulation of autophagy_Homo sapiens_hsa041400.01083729
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0274089
95Purine metabolism_Homo sapiens_hsa00230-0.0233023
96Bladder cancer_Homo sapiens_hsa05219-0.0196772
97Endocytosis_Homo sapiens_hsa04144-0.0171756
98Amoebiasis_Homo sapiens_hsa05146-0.0132484
99Apoptosis_Homo sapiens_hsa04210-0.0123181
100RNA degradation_Homo sapiens_hsa03018-0.0088927

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