DCBLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)6.87957020
2desmosome organization (GO:0002934)6.10626879
3endodermal cell differentiation (GO:0035987)5.60725682
4cell-substrate junction assembly (GO:0007044)5.42023671
5bundle of His cell to Purkinje myocyte communication (GO:0086069)4.79699243
6mesodermal cell differentiation (GO:0048333)4.61331274
7skin morphogenesis (GO:0043589)4.60906928
8cellular response to vitamin D (GO:0071305)4.51630703
9regulation of development, heterochronic (GO:0040034)4.21948197
10regulation of timing of cell differentiation (GO:0048505)4.08910000
11negative regulation of axon extension involved in axon guidance (GO:0048843)4.05805267
12wound healing, spreading of epidermal cells (GO:0035313)4.02967309
13cellular response to vitamin (GO:0071295)4.01146902
14keratinocyte development (GO:0003334)4.00005304
15negative regulation of chondrocyte differentiation (GO:0032331)3.96183288
16substrate-dependent cell migration (GO:0006929)3.82685446
17dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.72308454
18chondrocyte proliferation (GO:0035988)3.69996509
19retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62299751
20microtubule depolymerization (GO:0007019)3.60424610
21keratinocyte proliferation (GO:0043616)3.56614637
22heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.52645477
23atrial cardiac muscle cell action potential (GO:0086014)3.52111529
24lymphangiogenesis (GO:0001946)3.51542894
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49939477
26negative regulation of keratinocyte proliferation (GO:0010839)3.49590070
27collagen fibril organization (GO:0030199)3.47349794
28sequestering of extracellular ligand from receptor (GO:0035581)3.47209245
29cell migration involved in sprouting angiogenesis (GO:0002042)3.46600405
30renal filtration (GO:0097205)3.45101954
31gap junction assembly (GO:0016264)3.40267224
32mitotic metaphase plate congression (GO:0007080)3.40051096
33DNA integration (GO:0015074)3.39969767
34basement membrane organization (GO:0071711)3.39495837
35regulation of transforming growth factor beta2 production (GO:0032909)3.35511880
36extracellular matrix disassembly (GO:0022617)3.33448921
37paraxial mesoderm development (GO:0048339)3.33239090
38neural crest cell development (GO:0014032)3.25642654
39kinetochore assembly (GO:0051382)3.22162034
40collagen metabolic process (GO:0032963)3.21278101
41negative regulation of axon guidance (GO:1902668)3.19163834
42collagen catabolic process (GO:0030574)3.16528029
43smooth muscle tissue development (GO:0048745)3.16450352
44regulation of metalloenzyme activity (GO:0048552)3.11725524
45regulation of axon extension involved in axon guidance (GO:0048841)3.10142782
46establishment of planar polarity (GO:0001736)3.06488548
47establishment of tissue polarity (GO:0007164)3.06488548
48protein localization to endosome (GO:0036010)3.04627364
49type B pancreatic cell proliferation (GO:0044342)3.03405151
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.03132314
51multicellular organismal macromolecule metabolic process (GO:0044259)3.02998413
52maturation of 5.8S rRNA (GO:0000460)3.01713287
53substrate adhesion-dependent cell spreading (GO:0034446)2.98718069
54wound healing, spreading of cells (GO:0044319)2.95165550
55DNA replication checkpoint (GO:0000076)2.92598149
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92342190
57cell junction assembly (GO:0034329)2.91290779
58regulation of plasminogen activation (GO:0010755)2.90103022
59multicellular organismal metabolic process (GO:0044236)2.90020570
60sprouting angiogenesis (GO:0002040)2.89480149
61lung-associated mesenchyme development (GO:0060484)2.89457798
62multicellular organismal catabolic process (GO:0044243)2.89370832
63rRNA modification (GO:0000154)2.89304278
64protein K6-linked ubiquitination (GO:0085020)2.86153795
65hypotonic response (GO:0006971)2.85934676
66mammary gland development (GO:0030879)2.82856489
67notochord development (GO:0030903)2.82286794
68lateral sprouting from an epithelium (GO:0060601)2.82118431
69negative regulation of cartilage development (GO:0061037)2.81226438
70regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.80247652
71kinetochore organization (GO:0051383)2.79165549
72proteasome assembly (GO:0043248)2.79152545
73L-serine transport (GO:0015825)2.78699973
74polarized epithelial cell differentiation (GO:0030859)2.78614726
75regulation of positive chemotaxis (GO:0050926)2.76482886
76positive regulation of positive chemotaxis (GO:0050927)2.76066004
77regulation of double-strand break repair via homologous recombination (GO:0010569)2.76049109
78negative chemotaxis (GO:0050919)2.75781968
79ganglion development (GO:0061548)2.74608468
80endocardial cushion development (GO:0003197)2.73864338
81extracellular matrix organization (GO:0030198)2.72483711
82endothelial cell morphogenesis (GO:0001886)2.71726456
83extracellular structure organization (GO:0043062)2.71531511
84artery development (GO:0060840)2.70086174
85regulation of transcription from RNA polymerase I promoter (GO:0006356)2.66238747
86metaphase plate congression (GO:0051310)2.66122250
87COPII vesicle coating (GO:0048208)2.65805839
88heparan sulfate proteoglycan metabolic process (GO:0030201)2.65380821
89microtubule polymerization or depolymerization (GO:0031109)2.65367576
90regulation of axon guidance (GO:1902667)2.65335088
91axon extension involved in axon guidance (GO:0048846)2.64436468
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.64436468
93glomerular basement membrane development (GO:0032836)2.63837046
94cell junction organization (GO:0034330)2.62964758
95termination of RNA polymerase III transcription (GO:0006386)2.62784973
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.62784973
97positive regulation of osteoblast proliferation (GO:0033690)2.62651843
98adult feeding behavior (GO:0008343)2.62188900
99negative regulation of stem cell proliferation (GO:2000647)2.61947503
100kidney mesenchyme development (GO:0072074)2.61503628
101regulation of keratinocyte proliferation (GO:0010837)2.61279042
102pericardium development (GO:0060039)2.60445345
103mesenchymal-epithelial cell signaling (GO:0060638)2.60256758
104CENP-A containing nucleosome assembly (GO:0034080)2.59890327
105vascular endothelial growth factor signaling pathway (GO:0038084)2.59803991
106rRNA methylation (GO:0031167)2.58608999
107regulation of hippo signaling (GO:0035330)2.58582862
108chromatin remodeling at centromere (GO:0031055)2.58406192
109negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.58186844
110facial nerve structural organization (GO:0021612)2.56679855
111wound healing (GO:0042060)2.56539127
112negative regulation of androgen receptor signaling pathway (GO:0060766)2.56270100
113limb bud formation (GO:0060174)2.54683372
114intestinal epithelial cell development (GO:0060576)2.54046304
115regulation of cardioblast differentiation (GO:0051890)2.53754551
116lung vasculature development (GO:0060426)2.52477082
117kidney morphogenesis (GO:0060993)2.51122859
118regulation of helicase activity (GO:0051095)2.49699209
119protein localization to cell surface (GO:0034394)2.49625477
120regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49160547
121COPI coating of Golgi vesicle (GO:0048205)2.48895385
122Golgi transport vesicle coating (GO:0048200)2.48895385
123UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48124469
124regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.46996114
125termination of RNA polymerase I transcription (GO:0006363)2.46881109
126male sex determination (GO:0030238)2.46701863
127female gonad development (GO:0008585)2.46489767
128mesenchymal cell development (GO:0014031)2.46010736
129positive regulation of cardiac muscle cell proliferation (GO:0060045)2.45936313
130DNA damage response, detection of DNA damage (GO:0042769)2.45412660
131surfactant homeostasis (GO:0043129)2.45014970
132cell-matrix adhesion (GO:0007160)2.43312353
133purine nucleobase biosynthetic process (GO:0009113)2.43276358
134regulation of type B pancreatic cell apoptotic process (GO:2000674)2.43249536
135glomerular filtration (GO:0003094)2.43233088
136plasma membrane repair (GO:0001778)2.42874232
137blood vessel endothelial cell migration (GO:0043534)2.42002556
138centriole assembly (GO:0098534)2.39669165
139positive regulation of cardiac muscle tissue growth (GO:0055023)2.38040981
140proteoglycan biosynthetic process (GO:0030166)2.37630471
141single strand break repair (GO:0000012)2.37295533
142protein hydroxylation (GO:0018126)2.37232756
143chondroitin sulfate biosynthetic process (GO:0030206)2.36857324
144transcription elongation from RNA polymerase I promoter (GO:0006362)2.35760898
145nonmotile primary cilium assembly (GO:0035058)2.34296353
146forebrain neuron differentiation (GO:0021879)2.33377536
147ventricular trabecula myocardium morphogenesis (GO:0003222)2.32949961
148tRNA methylation (GO:0030488)2.31104713
149negative regulation of homotypic cell-cell adhesion (GO:0034111)2.29772381
150negative regulation of DNA-dependent DNA replication (GO:2000104)2.29696799
151regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.29045551
152regulation of mitotic spindle checkpoint (GO:1903504)2.29045551
153regulation of centrosome cycle (GO:0046605)2.28339905
154reciprocal meiotic recombination (GO:0007131)2.27968964
155reciprocal DNA recombination (GO:0035825)2.27968964
156poly(A)+ mRNA export from nucleus (GO:0016973)2.27961417
157detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26497253
158DNA ligation (GO:0006266)2.26317958
159spliceosomal snRNP assembly (GO:0000387)2.24563631
160regulation of telomere maintenance via telomerase (GO:0032210)2.23653882
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.23371428
162spindle checkpoint (GO:0031577)2.22654085
163meiotic chromosome segregation (GO:0045132)2.22546719
164somite rostral/caudal axis specification (GO:0032525)2.22348979
165negative regulation of chromosome segregation (GO:0051985)2.21009522
166regulation of gene expression by genetic imprinting (GO:0006349)2.20926575
167viral mRNA export from host cell nucleus (GO:0046784)2.20807478
168negative regulation of mitotic sister chromatid separation (GO:2000816)2.20730379
169negative regulation of mitotic sister chromatid segregation (GO:0033048)2.20730379
170negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.20730379
171negative regulation of sister chromatid segregation (GO:0033046)2.20730379
172cell proliferation in forebrain (GO:0021846)2.19570170
173negative regulation of transcription by competitive promoter binding (GO:0010944)2.19487821
174regulation of mitotic metaphase/anaphase transition (GO:0030071)2.19446189
175regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.18937777
176transcription from RNA polymerase I promoter (GO:0006360)2.18877954
177negative regulation of mitosis (GO:0045839)2.17475200
178otic vesicle formation (GO:0030916)2.17425750
179DNA methylation involved in gamete generation (GO:0043046)2.17261538
180negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.16558897
181interferon-gamma secretion (GO:0072643)2.16253307
182regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.16251957
183establishment of chromosome localization (GO:0051303)2.15031192
184regulation of mesoderm development (GO:2000380)2.14234859
185axoneme assembly (GO:0035082)2.14014819
186positive regulation of cardiac muscle tissue development (GO:0055025)2.13714599
187positive regulation of heart growth (GO:0060421)2.13651487
188mitotic spindle checkpoint (GO:0071174)2.13230303
1897-methylguanosine RNA capping (GO:0009452)2.12747266
190RNA capping (GO:0036260)2.12747266
191regulation of mitotic sister chromatid separation (GO:0010965)2.11699765
192regulation of mitotic sister chromatid segregation (GO:0033047)2.11699765
193regulation of sister chromatid segregation (GO:0033045)2.11699765
194righting reflex (GO:0060013)2.11464792
1957-methylguanosine mRNA capping (GO:0006370)2.11328294
196negative regulation of myoblast differentiation (GO:0045662)2.10859996
197retinal ganglion cell axon guidance (GO:0031290)2.09418064
198hemidesmosome assembly (GO:0031581)12.2018798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.04608807
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.03040643
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.57265072
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89791655
5CJUN_26792858_Chip-Seq_BT549_Human2.89652813
6GBX2_23144817_ChIP-Seq_PC3_Human2.73623739
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.56132072
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.56132072
9EZH2_22144423_ChIP-Seq_EOC_Human2.53914846
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.46376479
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.44371654
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42022596
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.41466160
14* BRD4_25478319_ChIP-Seq_HGPS_Human2.40213390
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.36851596
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32374480
17TP53_18474530_ChIP-ChIP_U2OS_Human2.26855815
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.25112598
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.19117291
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12649599
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12649599
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12649599
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12222136
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09745648
25TP63_17297297_ChIP-ChIP_HaCaT_Human10.4019336
26* GATA2_21666600_ChIP-Seq_HMVEC_Human1.93059716
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90670170
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90194494
29E2F7_22180533_ChIP-Seq_HELA_Human1.90045455
30VDR_22108803_ChIP-Seq_LS180_Human1.89877569
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88254010
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88129884
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87686697
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.85514081
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84357569
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.84264357
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82341472
38* SALL1_21062744_ChIP-ChIP_HESCs_Human1.80108365
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79723698
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79723698
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78624484
42RNF2_27304074_Chip-Seq_NSC_Mouse1.78261217
43JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75539515
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.73677990
45* TP63_23658742_ChIP-Seq_EP156T_Human1.72747426
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.72005868
47TP53_16413492_ChIP-PET_HCT116_Human1.69910776
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69862040
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68681506
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67395874
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65332355
52FUS_26573619_Chip-Seq_HEK293_Human1.64639712
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64191542
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64141330
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60762963
56SOX2_20726797_ChIP-Seq_SW620_Human1.60107144
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.57306027
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56499424
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.56036864
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.54236125
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53500636
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53069938
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51757177
64NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.51075559
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.48780740
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47396036
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.47323031
68* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47232772
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.46328366
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43408415
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42751709
72AHR_22903824_ChIP-Seq_MCF-7_Human1.38883109
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.38791081
74EWS_26573619_Chip-Seq_HEK293_Human1.38619328
75TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37821820
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37799972
77IRF1_19129219_ChIP-ChIP_H3396_Human1.37485032
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.37023531
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35244241
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34643554
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34601311
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33528231
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33182535
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.31344177
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31007663
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30449492
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29623162
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.28931399
89CLOCK_20551151_ChIP-Seq_293T_Human1.27787648
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27634961
91P300_19829295_ChIP-Seq_ESCs_Human1.26881264
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.26823475
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25767426
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25556184
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24860137
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24616428
97IGF1R_20145208_ChIP-Seq_DFB_Human1.23946903
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23284567
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.23004083
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.22306930
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21743650
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.21491397
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21122989
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20951572
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19876848
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.19433892
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18876477
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.18316648
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17900027
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16489493
111MYC_18555785_ChIP-Seq_MESCs_Mouse1.16349510
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.15887912
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13367490
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13152238
115TAF15_26573619_Chip-Seq_HEK293_Human1.12057818
116TP53_22127205_ChIP-Seq_IMR90_Human1.11224729
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10309315
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09869471
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09443305
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09288669
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07062202
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.06463303
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06249146
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05996910
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.05184479
126P53_22387025_ChIP-Seq_ESCs_Mouse1.04608359
127* EZH2_27294783_Chip-Seq_NPCs_Mouse1.04368538
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04140813
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04064030
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03731284
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03571037
132GATA4_25053715_ChIP-Seq_YYC3_Human1.03465746
133SMAD4_21799915_ChIP-Seq_A2780_Human1.03210909
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03004119
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02944373
136* CDX2_22108803_ChIP-Seq_LS180_Human1.02735305
137* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02616900
138FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02031393
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01515762
140NMYC_18555785_Chip-Seq_ESCs_Mouse1.01286562
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00062398
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99935237
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.99878804
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99754719
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99188693
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.99021987
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98930393
148TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98382653
149P300_18555785_Chip-Seq_ESCs_Mouse0.98356575
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.98179174
151EST1_17652178_ChIP-ChIP_JURKAT_Human0.98130945
152TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97745723
153MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97316926
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96985545
155* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96834537
156* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96834537
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96450222
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96007260
159* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95387764
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.94572201
161ZFX_18555785_Chip-Seq_ESCs_Mouse0.93842791
162JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93814895
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91096433
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90817885
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88160516
166SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87814204
167SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86102787
168* FOXA2_19822575_ChIP-Seq_HepG2_Human0.85961984
169EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84787517
170CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84442907
171ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82732215
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82429685
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82391600
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81908238
175SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80686092
176* TP53_23651856_ChIP-Seq_MEFs_Mouse0.78591738
177SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78407988
178ATF3_27146783_Chip-Seq_COLON_Human0.78128372
179KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77303910
180AR_21909140_ChIP-Seq_LNCAP_Human0.75795583
181SMAD4_21741376_ChIP-Seq_HESCs_Human0.75750420
182RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75322479
183RXR_22108803_ChIP-Seq_LS180_Human0.74773269
184GATA3_24758297_ChIP-Seq_MCF-7_Human0.74655993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane5.07298188
2MP0008438_abnormal_cutaneous_collagen4.93028828
3MP0000579_abnormal_nail_morphology4.47321869
4MP0006054_spinal_hemorrhage4.32246675
5MP0005275_abnormal_skin_tensile3.62377339
6MP0000566_synostosis3.47525971
7MP0003566_abnormal_cell_adhesion3.43707349
8MP0006292_abnormal_olfactory_placode3.21774552
9MP0010368_abnormal_lymphatic_system3.08076177
10MP0003705_abnormal_hypodermis_morpholog2.87695884
11MP0003136_yellow_coat_color2.84330211
12MP0003941_abnormal_skin_development2.81248550
13MP0001188_hyperpigmentation2.71064676
14MP0002102_abnormal_ear_morphology2.68703756
15MP0005623_abnormal_meninges_morphology2.66931869
16MP0005257_abnormal_intraocular_pressure2.63488542
17MP0002060_abnormal_skin_morphology2.47721389
18MP0003279_aneurysm2.37503949
19MP0003693_abnormal_embryo_hatching2.31460956
20MP0005023_abnormal_wound_healing2.25911038
21MP0005377_hearing/vestibular/ear_phenot2.24339817
22MP0003878_abnormal_ear_physiology2.24339817
23MP0003787_abnormal_imprinting2.23762118
24MP0003315_abnormal_perineum_morphology2.23197916
25MP0008260_abnormal_autophagy2.19852933
26MP0000467_abnormal_esophagus_morphology2.19180913
27MP0003718_maternal_effect2.15645511
28MP0003283_abnormal_digestive_organ2.10013063
29MP0009053_abnormal_anal_canal2.04411207
30MP0005645_abnormal_hypothalamus_physiol2.02384301
31MP0009780_abnormal_chondrocyte_physiolo1.92567062
32MP0009384_cardiac_valve_regurgitation1.92110058
33MP0005171_absent_coat_pigmentation1.90598246
34MP0001485_abnormal_pinna_reflex1.88941665
35MP0009697_abnormal_copulation1.84285781
36MP0008789_abnormal_olfactory_epithelium1.81765360
37MP0003111_abnormal_nucleus_morphology1.80670001
38MP0001958_emphysema1.77477732
39MP0001849_ear_inflammation1.76935382
40MP0008058_abnormal_DNA_repair1.75752546
41MP0003938_abnormal_ear_development1.75618162
42MP0005360_urolithiasis1.75452316
43MP0008995_early_reproductive_senescence1.73809086
44MP0010234_abnormal_vibrissa_follicle1.70907373
45MP0000013_abnormal_adipose_tissue1.68654452
46MP0005503_abnormal_tendon_morphology1.68620817
47MP0000049_abnormal_middle_ear1.67140972
48MP0010678_abnormal_skin_adnexa1.66973832
49MP0003121_genomic_imprinting1.62924705
50MP0001879_abnormal_lymphatic_vessel1.61118179
51MP0008057_abnormal_DNA_replication1.58705221
52MP0003890_abnormal_embryonic-extraembry1.58146720
53MP0010352_gastrointestinal_tract_polyps1.57021504
54MP0008877_abnormal_DNA_methylation1.54103859
55MP0003786_premature_aging1.53309944
56MP0002160_abnormal_reproductive_system1.53088408
57MP0000026_abnormal_inner_ear1.52988262
58MP0000767_abnormal_smooth_muscle1.52286843
59MP0003937_abnormal_limbs/digits/tail_de1.49748449
60MP0001216_abnormal_epidermal_layer1.49644301
61MP0002938_white_spotting1.48316767
62MP0010030_abnormal_orbit_morphology1.47485178
63MP0006276_abnormal_autonomic_nervous1.46018937
64MP0002277_abnormal_respiratory_mucosa1.44215691
65MP0003091_abnormal_cell_migration1.44021255
66MP0002896_abnormal_bone_mineralization1.43715447
67MP0005394_taste/olfaction_phenotype1.43489058
68MP0005499_abnormal_olfactory_system1.43489058
69MP0010094_abnormal_chromosome_stability1.42821381
70MP0001299_abnormal_eye_distance/1.41685302
71MP0000538_abnormal_urinary_bladder1.40890711
72MP0002249_abnormal_larynx_morphology1.40087362
73MP0002295_abnormal_pulmonary_circulatio1.38387744
74MP0008932_abnormal_embryonic_tissue1.37785204
75MP0004133_heterotaxia1.36572453
76MP0004742_abnormal_vestibular_system1.36515207
77MP0002163_abnormal_gland_morphology1.32550419
78MP0002234_abnormal_pharynx_morphology1.32436885
79MP0001486_abnormal_startle_reflex1.31021283
80MP0001986_abnormal_taste_sensitivity1.30694177
81MP0003119_abnormal_digestive_system1.29448983
82MP0003950_abnormal_plasma_membrane1.28860853
83MP0003880_abnormal_central_pattern1.28826197
84MP0001286_abnormal_eye_development1.28755517
85MP0000462_abnormal_digestive_system1.27790048
86MP0004957_abnormal_blastocyst_morpholog1.25202175
87MP0000762_abnormal_tongue_morphology1.23796027
88MP0001346_abnormal_lacrimal_gland1.23515845
89MP0005084_abnormal_gallbladder_morpholo1.22382150
90MP0005646_abnormal_pituitary_gland1.22078659
91MP0002876_abnormal_thyroid_physiology1.20568495
92MP0003755_abnormal_palate_morphology1.20083436
93MP0002233_abnormal_nose_morphology1.17488630
94MP0010771_integument_phenotype1.16373358
95MP0003122_maternal_imprinting1.14407360
96MP0000778_abnormal_nervous_system1.13717010
97MP0001963_abnormal_hearing_physiology1.12957457
98MP0005389_reproductive_system_phenotype1.10473361
99MP0001915_intracranial_hemorrhage1.08204545
100MP0005595_abnormal_vascular_smooth1.07746868
101MP0000372_irregular_coat_pigmentation1.07380597
102MP0005197_abnormal_uvea_morphology1.06973040
103MP0004134_abnormal_chest_morphology1.06605392
104MP0008004_abnormal_stomach_pH1.06113618
105MP0001984_abnormal_olfaction1.05200298
106MP0003385_abnormal_body_wall1.05159845
107MP0002735_abnormal_chemical_nociception1.04853330
108MP0000427_abnormal_hair_cycle1.03712624
109MP0000537_abnormal_urethra_morphology1.02809470
110MP0002751_abnormal_autonomic_nervous1.02679591
111MP0003077_abnormal_cell_cycle1.02301492
112MP0003453_abnormal_keratinocyte_physiol1.00754697
113MP0000631_abnormal_neuroendocrine_gland1.00693582
114MP0005508_abnormal_skeleton_morphology1.00667564
115MP0002653_abnormal_ependyma_morphology1.00439053
116MP0002638_abnormal_pupillary_reflex0.99642496
117MP0002127_abnormal_cardiovascular_syste0.99505932
118MP0005409_darkened_coat_color0.97928739
119MP0002098_abnormal_vibrissa_morphology0.97738708
120MP0002168_other_aberrant_phenotype0.96875752
121MP0001243_abnormal_dermal_layer0.96854282
122MP0003861_abnormal_nervous_system0.96176633
123MP0001293_anophthalmia0.95299928
124MP0003123_paternal_imprinting0.95176695
125MP0009379_abnormal_foot_pigmentation0.93709853
126MP0003936_abnormal_reproductive_system0.92606375
127MP0004264_abnormal_extraembryonic_tissu0.92565178
128MP0002116_abnormal_craniofacial_bone0.91848210
129MP0000383_abnormal_hair_follicle0.91088906
130MP0002282_abnormal_trachea_morphology0.90691886
131MP0000432_abnormal_head_morphology0.90285124
132MP0010386_abnormal_urinary_bladder0.89329010
133MP0002796_impaired_skin_barrier0.89132883
134MP0005379_endocrine/exocrine_gland_phen0.87911111
135MP0000534_abnormal_ureter_morphology0.87549983
136MP0005164_abnormal_response_to0.87483079
137MP0002877_abnormal_melanocyte_morpholog0.87180275
138MP0001529_abnormal_vocalization0.87093894
139MP0005248_abnormal_Harderian_gland0.87066085
140MP0003195_calcinosis0.86938164
141MP0000377_abnormal_hair_follicle0.86863297
142MP0005501_abnormal_skin_physiology0.86673694
143MP0000003_abnormal_adipose_tissue0.86455888
144MP0009250_abnormal_appendicular_skeleto0.85917969
145MP0000627_abnormal_mammary_gland0.85757425
146MP0002210_abnormal_sex_determination0.84414974
147MP0002184_abnormal_innervation0.84039201
148MP0002752_abnormal_somatic_nervous0.83775364
149MP0005165_increased_susceptibility_to0.83174622
150MP0002089_abnormal_postnatal_growth/wei0.82463144
151MP0003935_abnormal_craniofacial_develop0.82195212
152MP0008775_abnormal_heart_ventricle0.82147007
153MP0002177_abnormal_outer_ear0.81117482
154MP0001542_abnormal_bone_strength0.80226651
155MP0002085_abnormal_embryonic_tissue0.77937228
156MP0001119_abnormal_female_reproductive0.77664545
157MP0001440_abnormal_grooming_behavior0.76970300
158MP0002557_abnormal_social/conspecific_i0.76746176
159MP0003252_abnormal_bile_duct0.76227252
160MP0001614_abnormal_blood_vessel0.75472007
161MP0002734_abnormal_mechanical_nocicepti0.73298011
162MP0002925_abnormal_cardiovascular_devel0.72283188
163MP0003045_fibrosis0.72186083
164MP0000569_abnormal_digit_pigmentation0.71441728
165MP0000163_abnormal_cartilage_morphology0.70646844
166MP0001661_extended_life_span0.69101307
167MP0001191_abnormal_skin_condition0.68808150
168MP0000428_abnormal_craniofacial_morphol0.68725559
169MP0005193_abnormal_anterior_eye0.68035429
170MP0002128_abnormal_blood_circulation0.66996824
171MP0006138_congestive_heart_failure0.65439742
172MP0000733_abnormal_muscle_development0.64077148
173MP0000647_abnormal_sebaceous_gland0.64052897
174MP0003300_gastrointestinal_ulcer0.63005609
175MP0001348_abnormal_lacrimal_gland0.62929558
176MP0009931_abnormal_skin_appearance0.62015423
177MP0009840_abnormal_foam_cell0.59454358
178MP0005395_other_phenotype0.58491872
179MP0002254_reproductive_system_inflammat0.56980562
180MP0002139_abnormal_hepatobiliary_system0.56216815
181MP0000516_abnormal_urinary_system0.55602966

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)8.05170034
2Milia (HP:0001056)6.49140152
3Onycholysis (HP:0001806)5.93435217
4Fragile nails (HP:0001808)5.91997237
5Premature rupture of membranes (HP:0001788)5.74377962
6Plantar hyperkeratosis (HP:0007556)4.90294821
7Protrusio acetabuli (HP:0003179)4.42249494
8Fragile skin (HP:0001030)4.23698791
9Follicular hyperkeratosis (HP:0007502)4.11355383
10Arterial tortuosity (HP:0005116)4.04858244
11Vascular tortuosity (HP:0004948)3.96335812
12Thick nail (HP:0001805)3.79216513
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71109978
14Alopecia of scalp (HP:0002293)3.70303505
15Aortic dissection (HP:0002647)3.70028261
16Abnormality of nail color (HP:0100643)3.63048509
17Cardiovascular calcification (HP:0011915)3.45074406
18Nail dystrophy (HP:0008404)3.42369564
19Birth length less than 3rd percentile (HP:0003561)3.32591515
20Chromsome breakage (HP:0040012)3.31987151
21Breast hypoplasia (HP:0003187)3.21005220
22Right ventricular cardiomyopathy (HP:0011663)3.11432878
23Septo-optic dysplasia (HP:0100842)3.10306987
24Vascular calcification (HP:0004934)3.10030341
25Pterygium (HP:0001059)3.05468794
26Cervical subluxation (HP:0003308)3.01207763
27Abnormality of dentin (HP:0010299)2.94171123
28Absent radius (HP:0003974)2.91088533
29Soft skin (HP:0000977)2.90977707
30Palmoplantar hyperkeratosis (HP:0000972)2.88891816
31Absent forearm bone (HP:0003953)2.87834704
32Aplasia involving forearm bones (HP:0009822)2.87834704
33Natal tooth (HP:0000695)2.84296521
34Ankle contracture (HP:0006466)2.83756143
35Adrenal hypoplasia (HP:0000835)2.82155748
36Mitral stenosis (HP:0001718)2.75406105
37Supernumerary spleens (HP:0009799)2.73000286
38Wormian bones (HP:0002645)2.72953827
39Palmar hyperkeratosis (HP:0010765)2.72710638
40Abnormality of the labia minora (HP:0012880)2.72036628
41Bladder diverticulum (HP:0000015)2.71274319
42Abnormality of the preputium (HP:0100587)2.67826540
43Hypoplasia of dental enamel (HP:0006297)2.67355331
44Ridged nail (HP:0001807)2.62917181
45Meckel diverticulum (HP:0002245)2.61305920
46Aortic aneurysm (HP:0004942)2.58182994
47Patellar aplasia (HP:0006443)2.56230765
48Pancreatic fibrosis (HP:0100732)2.54584104
49Median cleft lip (HP:0000161)2.53127200
50Congenital sensorineural hearing impairment (HP:0008527)2.52393061
51Abnormal sex determination (HP:0012244)2.51218892
52Sex reversal (HP:0012245)2.51218892
53Fibular aplasia (HP:0002990)2.50995696
54Abnormality of the ileum (HP:0001549)2.45919339
55Aplasia/Hypoplasia of the patella (HP:0006498)2.43996368
56Tibial bowing (HP:0002982)2.35509515
57Short nail (HP:0001799)2.34354860
58Blue sclerae (HP:0000592)2.33634275
59Genu recurvatum (HP:0002816)2.29149102
60Facial cleft (HP:0002006)2.29004883
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.28582753
62Absent septum pellucidum (HP:0001331)2.26235037
63True hermaphroditism (HP:0010459)2.25157760
64Aplasia cutis congenita (HP:0001057)2.24836780
65Duplicated collecting system (HP:0000081)2.22575333
66Pili torti (HP:0003777)2.21855255
67Abnormality of carpal bone ossification (HP:0006257)2.20098448
68Ulnar bowing (HP:0003031)2.20082361
69Aplasia/hypoplasia of the uterus (HP:0008684)2.19332597
70Abnormal blistering of the skin (HP:0008066)2.19331046
71Abnormality of the septum pellucidum (HP:0007375)2.19112895
72Preaxial hand polydactyly (HP:0001177)2.18918639
73Shallow orbits (HP:0000586)2.18438254
74Hypoplasia of the fovea (HP:0007750)2.15621343
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.15621343
76Delayed gross motor development (HP:0002194)2.14040958
77Neonatal short-limb short stature (HP:0008921)2.12939600
78Spondylolisthesis (HP:0003302)2.12014867
79Absent hand (HP:0004050)2.11420767
80Spinal rigidity (HP:0003306)2.09967519
81Hyperalaninemia (HP:0003348)2.09139814
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09139814
83Abnormality of alanine metabolism (HP:0010916)2.09139814
84Ankyloglossia (HP:0010296)2.08786936
85Selective tooth agenesis (HP:0001592)2.08424261
86Aplasia involving bones of the upper limbs (HP:0009823)2.07388575
87Aplasia of the phalanges of the hand (HP:0009802)2.07388575
88Aplasia involving bones of the extremities (HP:0009825)2.07388575
89Abnormality of oral frenula (HP:0000190)2.07268157
90Duplication of thumb phalanx (HP:0009942)2.05886812
91Aplasia of the musculature (HP:0100854)2.05005725
92Pancreatic cysts (HP:0001737)2.04416399
93Broad metatarsal (HP:0001783)2.03036643
94Woolly hair (HP:0002224)2.01732250
95Osteomalacia (HP:0002749)2.01352637
96Abnormality of the renal collecting system (HP:0004742)2.00860487
97Triphalangeal thumb (HP:0001199)2.00597089
98Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00375825
99Abnormal hair laboratory examination (HP:0003328)1.98901306
100Optic nerve hypoplasia (HP:0000609)1.96807175
101Hydroxyprolinuria (HP:0003080)1.93611159
102Abnormality of proline metabolism (HP:0010907)1.93611159
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93333680
104Peritonitis (HP:0002586)1.91174962
105Split foot (HP:0001839)1.90444199
106Abnormal ossification of hand bones (HP:0005921)1.90394181
107Ectopic kidney (HP:0000086)1.90263965
108Absent eyebrow (HP:0002223)1.89769679
109Vertebral compression fractures (HP:0002953)1.89300026
110Short middle phalanx of the 5th finger (HP:0004220)1.89022583
111Shawl scrotum (HP:0000049)1.88771693
112Advanced eruption of teeth (HP:0006288)1.88478512
113Aortic regurgitation (HP:0001659)1.88113152
114Nasolacrimal duct obstruction (HP:0000579)1.86759312
115Conical tooth (HP:0000698)1.86162229
116Elbow flexion contracture (HP:0002987)1.85504993
117Vertebral arch anomaly (HP:0008438)1.84251593
118Small intestinal stenosis (HP:0012848)1.83623265
119Duodenal stenosis (HP:0100867)1.83623265
120Wrist flexion contracture (HP:0001239)1.83536527
121Occipital encephalocele (HP:0002085)1.83027918
122Osteolytic defects of the hand bones (HP:0009699)1.82180624
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.82180624
124Sparse eyelashes (HP:0000653)1.82148624
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81622726
126Hypodontia (HP:0000668)1.81554187
127Dry hair (HP:0011359)1.81391876
128Cerebral aneurysm (HP:0004944)1.80938286
129Aortic valve stenosis (HP:0001650)1.80690890
130Knee flexion contracture (HP:0006380)1.80546667
131Ectopic anus (HP:0004397)1.80311902
132Breast aplasia (HP:0100783)1.79899949
133Abnormality of the acetabulum (HP:0003170)1.79130241
134Impulsivity (HP:0100710)1.79006358
135Parakeratosis (HP:0001036)1.78842249
136Hypoplasia of the uterus (HP:0000013)1.78272334
137Mitral valve prolapse (HP:0001634)1.77548237
138Medial flaring of the eyebrow (HP:0010747)1.76623046
139Coxa vara (HP:0002812)1.75865083
140Cutaneous syndactyly (HP:0012725)1.75488582
141Aplasia/Hypoplasia of the breasts (HP:0010311)1.75467470
142Protruding ear (HP:0000411)1.75030199
143Abnormality of chromosome stability (HP:0003220)1.74242545
144Abnormality of the axillary hair (HP:0100134)1.74185632
145Abnormality of secondary sexual hair (HP:0009888)1.74185632
146Bowing of the arm (HP:0006488)1.74017129
147Bowed forearm bones (HP:0003956)1.74017129
148Hypoplastic labia majora (HP:0000059)1.71559457
149Hypotrichosis (HP:0001006)1.71097326
150Abnormal hand bone ossification (HP:0010660)1.70426279
151Abnormality of incisor morphology (HP:0011063)1.69761210
152Febrile seizures (HP:0002373)1.69061469
153Abnormality of the lacrimal duct (HP:0011481)1.68993845
154Corneal dystrophy (HP:0001131)1.68497640
155Popliteal pterygium (HP:0009756)1.68389511
156Cutaneous finger syndactyly (HP:0010554)1.67711789
157Rough bone trabeculation (HP:0100670)1.67434891
158Limited hip movement (HP:0008800)1.66561243
159Absent thumb (HP:0009777)1.65729023
160Male pseudohermaphroditism (HP:0000037)1.65707607
161Abnormality of the fetal cardiovascular system (HP:0010948)1.65274207
162Abnormal umbilical cord blood vessels (HP:0011403)1.65274207
163Single umbilical artery (HP:0001195)1.65274207
164Abnormal delivery (HP:0001787)1.64839540
165Aplasia/hypoplasia of the humerus (HP:0006507)1.64809161
166Hyperextensible skin (HP:0000974)1.62729779
167Joint laxity (HP:0001388)1.62716206
168Ovoid vertebral bodies (HP:0003300)1.61795336
169Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61675253
170Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61269270
171Gait imbalance (HP:0002141)1.61145736
172Nephroblastoma (Wilms tumor) (HP:0002667)1.61141754
173Ureteral duplication (HP:0000073)1.60683372
174Abnormal ciliary motility (HP:0012262)1.60472373
175Poor coordination (HP:0002370)1.60294285
176Tetraparesis (HP:0002273)1.60254130
177Cerebral hypomyelination (HP:0006808)1.59408979
178Oligodactyly (hands) (HP:0001180)1.59393425
179Rectovaginal fistula (HP:0000143)1.58163357
180Rectal fistula (HP:0100590)1.58163357
181Carious teeth (HP:0000670)1.57815816
182Abnormality of placental membranes (HP:0011409)1.57790296
183Amniotic constriction ring (HP:0009775)1.57790296
184Aplasia/Hypoplasia of the ulna (HP:0006495)1.57660303
185Anonychia (HP:0001798)1.57456380
186Abnormality of DNA repair (HP:0003254)1.57109602
187Abnormality of the nasal septum (HP:0000419)1.56979829
188Overgrowth (HP:0001548)1.56859816
189Abnormality of the nasolacrimal system (HP:0000614)1.56689547
190Horseshoe kidney (HP:0000085)1.56470031
191Small epiphyses (HP:0010585)1.56207324
192Mesomelia (HP:0003027)1.53964014
193Dilatation of the ascending aorta (HP:0005111)1.52346112
194Coronal craniosynostosis (HP:0004440)1.52326611
195Sparse scalp hair (HP:0002209)1.50323308
196Radial bowing (HP:0002986)1.49495350
197Hydroureter (HP:0000072)1.49439884
198Hoarse voice (HP:0001609)1.49407703
199Increased corneal curvature (HP:0100692)1.49185989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.55973156
2MST1R3.47422617
3MET3.44358289
4SRPK13.26678035
5CASK3.21571515
6AKT33.17844794
7MKNK23.06325486
8NTRK12.85492472
9PDGFRA2.83580174
10PTK22.69912424
11MYLK2.58582651
12BUB12.52988038
13PLK42.51820298
14STK162.35889977
15MKNK12.33274029
16STK38L2.26264955
17FLT32.19366070
18ARAF2.15390211
19ZAK2.04943813
20TGFBR22.00346618
21PIM21.96190072
22TTK1.92287809
23BCR1.90995036
24WEE11.89149169
25TTN1.83297615
26PAK41.83044393
27DDR21.77224647
28LMTK21.71054207
29BMPR1B1.69699479
30MAP3K21.69174010
31EIF2AK11.68132256
32PBK1.61076948
33GRK11.48271105
34CHEK21.46872065
35LIMK11.45193898
36DYRK21.44594837
37TRPM71.43070335
38EPHB21.42097560
39RIPK11.41638418
40PAK21.38900787
41SIK11.37236089
42TGFBR11.34599164
43WNK31.34147208
44NEK91.32848291
45PLK11.32402260
46NEK61.31638775
47BRAF1.30017710
48PNCK1.29898628
49SIK31.27686065
50LATS21.25260800
51MAP2K71.25105851
52MAP3K121.25048585
53BMPR21.23624344
54EIF2AK21.23035614
55INSRR1.22157311
56TNIK1.17872897
57EPHA41.17691113
58ADRBK11.13153025
59EIF2AK31.11638708
60PLK31.11005307
61BLK1.10919609
62NUAK11.10663801
63ERBB31.10071784
64CDK81.09733228
65TIE11.08589303
66MAPK131.05887020
67AURKA1.04776511
68PTK2B1.03741280
69PDGFRB1.03682995
70ROCK21.03113454
71MELK1.02605077
72ROCK11.00881582
73CDK70.99728939
74WNK40.99140601
75STK380.98029259
76CDC70.96554873
77STK30.96324501
78PRKG20.93675539
79DYRK1A0.93102410
80PIK3CG0.89914102
81NEK20.89585196
82YES10.89552187
83KSR10.87280039
84CDK30.86930456
85ADRBK20.86449404
86ERBB40.86208730
87TSSK60.85752944
88IRAK20.84839099
89ILK0.84300311
90PRKD20.83602191
91MARK10.83130242
92VRK10.82947390
93LATS10.82669406
94STK240.81836978
95DYRK30.81235294
96MAP2K60.80523503
97ERN10.80414872
98PLK20.80065698
99MAPKAPK30.78014474
100PRKCI0.74373342
101MAP3K30.74120551
102ABL20.73793159
103OXSR10.73170862
104BRSK20.72954267
105MAPKAPK50.72670159
106GSK3A0.72241320
107ACVR1B0.71486865
108MUSK0.71036948
109NLK0.69922644
110RAF10.67935394
111AURKB0.67303456
112MAP2K20.65615756
113PIK3CA0.64560885
114CDK120.64460865
115TLK10.63097574
116TESK10.62721732
117NME10.61104819
118IRAK30.60576811
119STK390.59212463
120FRK0.57520144
121RPS6KA20.56813428
122CHEK10.56477805
123ATR0.56382588
124PRKCE0.55366585
125WNK10.54539907
126CDC42BPA0.53629112
127TAOK20.53144784
128FER0.51415069
129CAMK1G0.50935398
130PAK30.50602435
131MOS0.47754168
132KSR20.47193083
133NTRK30.47066070
134STK100.46726019
135MAP2K10.45355921
136MAP3K90.44054146
137ATM0.43375080
138FGFR10.42854097
139BRD40.42287909
140CSNK1A1L0.41789327
141CDK90.41105179
142PRKCG0.40844776
143CDK10.39892763
144MST40.39850660
145CSNK2A10.39726007
146EPHB10.39564305
147PHKG10.39146196
148PHKG20.39146196
149MAP3K40.38896736
150CSNK1E0.38505360
151PAK60.38497180
152IRAK10.38017096
153ERBB20.37203947
154PINK10.37177901
155CAMK2G0.35422420
156CSNK1A10.34992130
157CDK20.34358477
158SGK20.33848676
159KDR0.32665485
160INSR0.32521427
161SGK2230.32464871
162IGF1R0.32218041
163MTOR0.29968261
164PKN20.29791114
165MAP4K20.27485632
166MAP3K80.26252442

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.96333324
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.91239267
3RNA polymerase_Homo sapiens_hsa030203.50062760
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00355543
5Focal adhesion_Homo sapiens_hsa045102.94642959
6Fanconi anemia pathway_Homo sapiens_hsa034602.93935910
7Proteasome_Homo sapiens_hsa030502.76421533
8Basal transcription factors_Homo sapiens_hsa030222.59170891
9Small cell lung cancer_Homo sapiens_hsa052222.57838680
10Mismatch repair_Homo sapiens_hsa034302.54866136
11Homologous recombination_Homo sapiens_hsa034402.46621733
12Vitamin B6 metabolism_Homo sapiens_hsa007502.28472055
13RNA transport_Homo sapiens_hsa030132.26035850
14Spliceosome_Homo sapiens_hsa030402.22739319
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09046772
16Cell cycle_Homo sapiens_hsa041102.05934550
17Nicotine addiction_Homo sapiens_hsa050332.03495233
18Nucleotide excision repair_Homo sapiens_hsa034201.94531622
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88774574
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.88271878
21Proteoglycans in cancer_Homo sapiens_hsa052051.87217880
22Amoebiasis_Homo sapiens_hsa051461.81292726
23DNA replication_Homo sapiens_hsa030301.76934977
24Sphingolipid metabolism_Homo sapiens_hsa006001.75174435
25Pyrimidine metabolism_Homo sapiens_hsa002401.74965941
26Non-homologous end-joining_Homo sapiens_hsa034501.74564472
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70127893
28Dilated cardiomyopathy_Homo sapiens_hsa054141.64131734
29Vitamin digestion and absorption_Homo sapiens_hsa049771.64075047
30N-Glycan biosynthesis_Homo sapiens_hsa005101.63051772
31Sulfur metabolism_Homo sapiens_hsa009201.61287012
32RNA degradation_Homo sapiens_hsa030181.58874871
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57046703
34mRNA surveillance pathway_Homo sapiens_hsa030151.51167658
35Complement and coagulation cascades_Homo sapiens_hsa046101.50532888
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.49533810
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47055664
38Base excision repair_Homo sapiens_hsa034101.46522368
39Basal cell carcinoma_Homo sapiens_hsa052171.45981708
40Arachidonic acid metabolism_Homo sapiens_hsa005901.45572753
41Purine metabolism_Homo sapiens_hsa002301.44768177
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44210801
43Regulation of autophagy_Homo sapiens_hsa041401.42205282
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39479192
45Hippo signaling pathway_Homo sapiens_hsa043901.34852412
46Bladder cancer_Homo sapiens_hsa052191.34028645
47Hedgehog signaling pathway_Homo sapiens_hsa043401.33733074
48p53 signaling pathway_Homo sapiens_hsa041151.32593759
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31668137
50Mineral absorption_Homo sapiens_hsa049781.27018899
51Taste transduction_Homo sapiens_hsa047421.24970684
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23503036
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20516922
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19087009
55Dorso-ventral axis formation_Homo sapiens_hsa043201.18842047
56Ether lipid metabolism_Homo sapiens_hsa005651.12274710
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12223041
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08735819
59Huntingtons disease_Homo sapiens_hsa050161.05365639
60Phototransduction_Homo sapiens_hsa047441.04210719
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03763189
62One carbon pool by folate_Homo sapiens_hsa006701.01296745
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00164784
64Selenocompound metabolism_Homo sapiens_hsa004500.98615932
65Folate biosynthesis_Homo sapiens_hsa007900.97316514
66Arginine and proline metabolism_Homo sapiens_hsa003300.96522650
67Axon guidance_Homo sapiens_hsa043600.96323252
68Wnt signaling pathway_Homo sapiens_hsa043100.96248176
69Serotonergic synapse_Homo sapiens_hsa047260.95604843
70Linoleic acid metabolism_Homo sapiens_hsa005910.94719369
71Oxidative phosphorylation_Homo sapiens_hsa001900.94471003
72Tight junction_Homo sapiens_hsa045300.94415106
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.94253617
74Other glycan degradation_Homo sapiens_hsa005110.92411948
75Ribosome_Homo sapiens_hsa030100.92242779
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90595766
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90306933
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90093726
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89149815
80Protein export_Homo sapiens_hsa030600.88642957
81Melanoma_Homo sapiens_hsa052180.87220832
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87139525
83Adherens junction_Homo sapiens_hsa045200.80873624
84Lysosome_Homo sapiens_hsa041420.80011129
85TGF-beta signaling pathway_Homo sapiens_hsa043500.79732361
86Notch signaling pathway_Homo sapiens_hsa043300.74346803
87Vibrio cholerae infection_Homo sapiens_hsa051100.73981185
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71832315
89Circadian rhythm_Homo sapiens_hsa047100.71564388
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.71316969
91ABC transporters_Homo sapiens_hsa020100.69194590
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67718470
93Steroid biosynthesis_Homo sapiens_hsa001000.67270383
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66952781
95Protein digestion and absorption_Homo sapiens_hsa049740.66785247
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.65055697
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63165827
98Parkinsons disease_Homo sapiens_hsa050120.60810110
99Galactose metabolism_Homo sapiens_hsa000520.60780027
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59270849
101Bile secretion_Homo sapiens_hsa049760.57477608
102Thyroid cancer_Homo sapiens_hsa052160.55017409
103Shigellosis_Homo sapiens_hsa051310.54048105
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52276063
105Prostate cancer_Homo sapiens_hsa052150.52152183
106Oocyte meiosis_Homo sapiens_hsa041140.51311755
107Metabolic pathways_Homo sapiens_hsa011000.51133585
108Epstein-Barr virus infection_Homo sapiens_hsa051690.50427674
109Prion diseases_Homo sapiens_hsa050200.50286968
110Toxoplasmosis_Homo sapiens_hsa051450.49922329
111Thyroid hormone synthesis_Homo sapiens_hsa049180.49878240
112Collecting duct acid secretion_Homo sapiens_hsa049660.48777906
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47532137
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47051689
115Glycerolipid metabolism_Homo sapiens_hsa005610.46631515
116Glutamatergic synapse_Homo sapiens_hsa047240.46162151
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45069658
118Autoimmune thyroid disease_Homo sapiens_hsa053200.43287251
119Pathways in cancer_Homo sapiens_hsa052000.42820761
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42620498
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.42589795
122Malaria_Homo sapiens_hsa051440.42360143
123Alzheimers disease_Homo sapiens_hsa050100.41904025
124Glutathione metabolism_Homo sapiens_hsa004800.41588747
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41553707
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40718369
127MicroRNAs in cancer_Homo sapiens_hsa052060.40267000
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40254512
129Starch and sucrose metabolism_Homo sapiens_hsa005000.39529398
130GABAergic synapse_Homo sapiens_hsa047270.39175734
131Morphine addiction_Homo sapiens_hsa050320.39126455
132Renin secretion_Homo sapiens_hsa049240.38340286
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37604576
134Calcium signaling pathway_Homo sapiens_hsa040200.35928895
135Fatty acid biosynthesis_Homo sapiens_hsa000610.35542032
136Renin-angiotensin system_Homo sapiens_hsa046140.34836874
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33934370
138Glioma_Homo sapiens_hsa052140.33312563
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33266742
140Rap1 signaling pathway_Homo sapiens_hsa040150.33140749
141Ras signaling pathway_Homo sapiens_hsa040140.32795135
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.32284462
143Nitrogen metabolism_Homo sapiens_hsa009100.31981044
144ErbB signaling pathway_Homo sapiens_hsa040120.31412750
145Gap junction_Homo sapiens_hsa045400.31338163
146Choline metabolism in cancer_Homo sapiens_hsa052310.31212862
147Ovarian steroidogenesis_Homo sapiens_hsa049130.30526115
148Melanogenesis_Homo sapiens_hsa049160.30008341
149TNF signaling pathway_Homo sapiens_hsa046680.29531723
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28725408
151African trypanosomiasis_Homo sapiens_hsa051430.28459779
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28101911
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27965974
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27877940
155Butanoate metabolism_Homo sapiens_hsa006500.27686294
156Fructose and mannose metabolism_Homo sapiens_hsa000510.27604419
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27379681
158PPAR signaling pathway_Homo sapiens_hsa033200.26343054
159Retinol metabolism_Homo sapiens_hsa008300.26093676
160Pancreatic secretion_Homo sapiens_hsa049720.25834669
161Pancreatic cancer_Homo sapiens_hsa052120.23528675

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