DCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)9.33828920
2desmosome organization (GO:0002934)9.02790597
3regulation of water loss via skin (GO:0033561)8.85610324
4intermediate filament cytoskeleton organization (GO:0045104)7.72939288
5intermediate filament-based process (GO:0045103)7.50616896
6hair follicle morphogenesis (GO:0031069)7.20069031
7linoleic acid metabolic process (GO:0043651)6.41414817
8epidermis development (GO:0008544)6.26673746
9keratinocyte differentiation (GO:0030216)6.19332683
10peptide cross-linking (GO:0018149)6.07872963
11keratinocyte proliferation (GO:0043616)5.82307590
12multicellular organismal water homeostasis (GO:0050891)5.82026165
13phosphatidylinositol acyl-chain remodeling (GO:0036149)5.20609838
14phosphatidylserine acyl-chain remodeling (GO:0036150)5.18464312
15long-chain fatty acid biosynthetic process (GO:0042759)5.02112111
16water homeostasis (GO:0030104)4.98451336
17epidermal cell differentiation (GO:0009913)4.90532093
18retinol metabolic process (GO:0042572)4.84377711
19very long-chain fatty acid metabolic process (GO:0000038)4.47869514
20hair cycle process (GO:0022405)4.42351359
21molting cycle process (GO:0022404)4.42351359
22long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.42228179
23long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.30183273
24phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.23720669
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.02565260
26lipoxygenase pathway (GO:0019372)3.96446995
27fatty-acyl-CoA biosynthetic process (GO:0046949)3.86720526
28phosphatidylcholine acyl-chain remodeling (GO:0036151)3.85528251
29primary alcohol metabolic process (GO:0034308)3.66986490
30regulation of sequestering of triglyceride (GO:0010889)3.56055151
31fatty-acyl-CoA metabolic process (GO:0035337)3.51302072
32positive regulation of chemokine secretion (GO:0090197)3.49876399
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.45383531
34hemidesmosome assembly (GO:0031581)3.20574565
35behavioral response to nicotine (GO:0035095)3.18238297
36acyl-CoA biosynthetic process (GO:0071616)3.13972702
37thioester biosynthetic process (GO:0035384)3.13972702
38viral transcription (GO:0019083)3.13281606
39epithelium development (GO:0060429)3.08523728
40keratinocyte development (GO:0003334)3.08171597
41regulation of chemokine secretion (GO:0090196)3.06754901
42molting cycle (GO:0042303)22.6078307
43hair cycle (GO:0042633)22.6078307
44lateral sprouting from an epithelium (GO:0060601)2.98462604
45translational termination (GO:0006415)2.95961788
46positive regulation of keratinocyte differentiation (GO:0045618)2.89550415
47phosphatidylserine metabolic process (GO:0006658)2.89480063
48response to phenylpropanoid (GO:0080184)2.88465182
49virion attachment to host cell (GO:0019062)2.87684518
50adhesion of symbiont to host cell (GO:0044650)2.87684518
51primary alcohol catabolic process (GO:0034310)2.86848384
52ribosomal small subunit biogenesis (GO:0042274)2.83321319
53one-carbon compound transport (GO:0019755)2.76566424
54phospholipid catabolic process (GO:0009395)2.69202698
55establishment of tissue polarity (GO:0007164)2.68533282
56establishment of planar polarity (GO:0001736)2.68533282
57ribosomal small subunit assembly (GO:0000028)2.66870190
58parturition (GO:0007567)2.57941660
59cell proliferation in forebrain (GO:0021846)2.57219866
60negative regulation of keratinocyte proliferation (GO:0010839)2.53222821
61positive regulation of epidermal cell differentiation (GO:0045606)2.52891464
62regulation of keratinocyte differentiation (GO:0045616)2.48790774
63regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.46546148
64unsaturated fatty acid biosynthetic process (GO:0006636)2.40515772
65translational elongation (GO:0006414)2.40335513
66phosphatidylglycerol metabolic process (GO:0046471)2.35007391
67triglyceride biosynthetic process (GO:0019432)2.34885062
68regulation of heart rate by cardiac conduction (GO:0086091)2.34714553
69axon ensheathment in central nervous system (GO:0032291)2.32417679
70central nervous system myelination (GO:0022010)2.32417679
71neutral lipid biosynthetic process (GO:0046460)2.28010559
72acylglycerol biosynthetic process (GO:0046463)2.28010559
73hair follicle development (GO:0001942)2.27400968
74adhesion of symbiont to host (GO:0044406)2.27136452
75icosanoid secretion (GO:0032309)2.26772718
76arachidonic acid secretion (GO:0050482)2.26772718
77glandular epithelial cell differentiation (GO:0002067)2.26286159
78fatty acid biosynthetic process (GO:0006633)2.26265019
79viral life cycle (GO:0019058)2.26185443
80ethanol metabolic process (GO:0006067)2.23906914
81carnitine metabolic process (GO:0009437)2.21578545
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.18936601
83substrate-independent telencephalic tangential migration (GO:0021826)2.16016665
84substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.16016665
85cotranslational protein targeting to membrane (GO:0006613)2.15875424
86protein targeting to ER (GO:0045047)2.15328532
87epithelial cell fate commitment (GO:0072148)2.14250165
88alditol phosphate metabolic process (GO:0052646)2.13530323
89ectoderm development (GO:0007398)2.12249897
90positive regulation of epidermis development (GO:0045684)2.10421853
91regulation of phospholipase A2 activity (GO:0032429)2.10161480
92acyl-CoA metabolic process (GO:0006637)2.10028686
93thioester metabolic process (GO:0035383)2.10028686
94alpha-linolenic acid metabolic process (GO:0036109)2.07266831
95establishment of protein localization to endoplasmic reticulum (GO:0072599)2.07185006
96phosphatidic acid metabolic process (GO:0046473)2.07020588
97phosphatidic acid biosynthetic process (GO:0006654)2.07020588
98keratinization (GO:0031424)12.7366045
99intermediate filament organization (GO:0045109)12.0980715
100establishment of skin barrier (GO:0061436)10.7453568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.02895503
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.39986017
3EZH2_22144423_ChIP-Seq_EOC_Human3.41765582
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.08470496
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.55781670
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32936498
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19275975
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.16616865
9SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07176288
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.02422338
11RNF2_27304074_Chip-Seq_ESCs_Mouse2.01123845
12BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93143546
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83704883
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.70226330
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66639495
16BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.66113198
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66112575
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65390328
19TP53_20018659_ChIP-ChIP_R1E_Mouse1.60722651
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55346966
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55346966
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52678621
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52578849
24CTCF_20526341_ChIP-Seq_ESCs_Human1.51581691
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.51444374
26CTCF_27219007_Chip-Seq_Bcells_Human1.50742964
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47672119
28* TAF2_19829295_ChIP-Seq_ESCs_Human1.45131851
29RXR_22108803_ChIP-Seq_LS180_Human1.43944275
30RNF2_27304074_Chip-Seq_NSC_Mouse1.41436312
31TP63_22573176_ChIP-Seq_HFKS_Human1.41113636
32RING1B_27294783_Chip-Seq_ESCs_Mouse1.36272602
33REST_21632747_ChIP-Seq_MESCs_Mouse1.32629555
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31413929
35TP63_23658742_ChIP-Seq_EP156T_Human1.30716390
36NCOR_22424771_ChIP-Seq_293T_Human1.30270282
37* ERG_20517297_ChIP-Seq_VCAP_Human1.29795885
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29476093
39VDR_22108803_ChIP-Seq_LS180_Human1.28025675
40* FOXH1_21741376_ChIP-Seq_ESCs_Human1.27861717
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26781150
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26524880
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24961042
44GATA6_21074721_ChIP-Seq_CACO-2_Human1.24375121
45CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23097520
46P53_21459846_ChIP-Seq_SAOS-2_Human1.22534766
47* E2F1_20622854_ChIP-Seq_HELA_Human1.20944923
48AR_21572438_ChIP-Seq_LNCaP_Human1.20591038
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19182284
50* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17998340
51* FOXA1_25329375_ChIP-Seq_VCAP_Human1.17998340
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15829686
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15829686
54P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15714681
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14966089
56* BCL6_27268052_Chip-Seq_Bcells_Human1.14826132
57ZNF274_21170338_ChIP-Seq_K562_Hela1.11056747
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.10946146
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10487545
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.07045360
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06329173
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05642647
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05359921
64* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04213667
65ERA_21632823_ChIP-Seq_H3396_Human1.03113546
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01627316
67NANOG_20526341_ChIP-Seq_ESCs_Human0.99597074
68HTT_18923047_ChIP-ChIP_STHdh_Human0.98369713
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97788356
70CBP_20019798_ChIP-Seq_JUKART_Human0.97788356
71AR_25329375_ChIP-Seq_VCAP_Human0.97266960
72P68_20966046_ChIP-Seq_HELA_Human0.97069977
73SMAD3_21741376_ChIP-Seq_EPCs_Human0.96990652
74* YY1_22570637_ChIP-Seq_MALME-3M_Human0.96327898
75MYC_19829295_ChIP-Seq_ESCs_Human0.96204059
76* BCOR_27268052_Chip-Seq_Bcells_Human0.94188356
77GBX2_23144817_ChIP-Seq_PC3_Human0.94146203
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92490528
79* FOXH1_21741376_ChIP-Seq_EPCs_Human0.90526368
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90026309
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.89906743
82HNFA_21074721_ChIP-Seq_CACO-2_Human0.89283293
83* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89149498
84PHF8_20622853_ChIP-Seq_HELA_Human0.89113362
85TCF4_22108803_ChIP-Seq_LS180_Human0.88905103
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88016319
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87558034
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86868052
89FUS_26573619_Chip-Seq_HEK293_Human0.85159704
90RBPJ_21746931_ChIP-Seq_IB4_Human0.83957258
91ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82179893
92OCT1_27270436_Chip-Seq_PROSTATE_Human0.82009312
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.81800969
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81643735
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80591279
96* OCT4_20526341_ChIP-Seq_ESCs_Human0.80484995
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78814425
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77447301
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77310230
100TP53_18474530_ChIP-ChIP_U2OS_Human0.77103663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.04938974
2MP0002796_impaired_skin_barrier6.12476811
3MP0005275_abnormal_skin_tensile5.90419584
4MP0000647_abnormal_sebaceous_gland5.65590260
5MP0004381_abnormal_hair_follicle4.66659355
6MP0000579_abnormal_nail_morphology4.54533457
7MP0002098_abnormal_vibrissa_morphology4.54491147
8MP0010234_abnormal_vibrissa_follicle3.56519895
9MP0001188_hyperpigmentation3.53749929
10MP0005501_abnormal_skin_physiology3.39851928
11MP0000377_abnormal_hair_follicle3.03505579
12MP0000383_abnormal_hair_follicle2.65386195
13MP0002095_abnormal_skin_pigmentation2.57946731
14MP0005075_abnormal_melanosome_morpholog2.43559469
15MP0010678_abnormal_skin_adnexa2.41977123
16MP0004885_abnormal_endolymph2.41763096
17MP0001216_abnormal_epidermal_layer2.31449207
18MP0003011_delayed_dark_adaptation2.28663830
19MP0004947_skin_inflammation2.17120475
20MP0000566_synostosis2.11603324
21MP0003453_abnormal_keratinocyte_physiol2.10583559
22MP0010771_integument_phenotype2.10167936
23MP0000427_abnormal_hair_cycle2.03839086
24MP0003878_abnormal_ear_physiology2.03053153
25MP0005377_hearing/vestibular/ear_phenot2.03053153
26MP0005409_darkened_coat_color1.96293562
27MP0000367_abnormal_coat/_hair1.83603229
28MP0002060_abnormal_skin_morphology1.81512588
29MP0005174_abnormal_tail_pigmentation1.66690090
30MP0000015_abnormal_ear_pigmentation1.61511661
31MP0003705_abnormal_hypodermis_morpholog1.35811135
32MP0006292_abnormal_olfactory_placode1.31993188
33MP0009931_abnormal_skin_appearance1.29979094
34MP0000467_abnormal_esophagus_morphology1.24830918
35MP0001243_abnormal_dermal_layer1.19370116
36MP0005646_abnormal_pituitary_gland1.07620056
37MP0005647_abnormal_sex_gland1.02562736
38MP0001984_abnormal_olfaction0.94907541
39MP0003646_muscle_fatigue0.94843683
40MP0008789_abnormal_olfactory_epithelium0.89889407
41MP0001191_abnormal_skin_condition0.89002662
42MP0001485_abnormal_pinna_reflex0.84250932
43MP0002163_abnormal_gland_morphology0.82272443
44MP0010030_abnormal_orbit_morphology0.76757007
45MP0002282_abnormal_trachea_morphology0.74543511
46MP0009053_abnormal_anal_canal0.71779837
47MP0000762_abnormal_tongue_morphology0.69812114
48MP0002177_abnormal_outer_ear0.68967001
49MP0005499_abnormal_olfactory_system0.68414722
50MP0005394_taste/olfaction_phenotype0.68414722
51MP0002837_dystrophic_cardiac_calcinosis0.64800884
52MP0005551_abnormal_eye_electrophysiolog0.64596585
53MP0003941_abnormal_skin_development0.63194498
54MP0002653_abnormal_ependyma_morphology0.61521525
55MP0004742_abnormal_vestibular_system0.60317130
56MP0004782_abnormal_surfactant_physiolog0.59705721
57MP0002234_abnormal_pharynx_morphology0.58996982
58MP0000049_abnormal_middle_ear0.56784579
59MP0005389_reproductive_system_phenotype0.56182261
60MP0002249_abnormal_larynx_morphology0.56175311
61MP0001919_abnormal_reproductive_system0.53376201
62MP0002638_abnormal_pupillary_reflex0.50789228
63MP0009780_abnormal_chondrocyte_physiolo0.49233001
64MP0003638_abnormal_response/metabolism_0.48381129
65MP0005379_endocrine/exocrine_gland_phen0.48113736
66MP0002160_abnormal_reproductive_system0.48031067
67MP0000778_abnormal_nervous_system0.44708588
68MP0001784_abnormal_fluid_regulation0.44543771
69MP0000678_abnormal_parathyroid_gland0.42944405
70MP0004019_abnormal_vitamin_homeostasis0.42598409
71MP0003787_abnormal_imprinting0.41679231
72MP0006035_abnormal_mitochondrial_morpho0.41580555
73MP0005423_abnormal_somatic_nervous0.40955743
74MP0000026_abnormal_inner_ear0.40250548
75MP0003880_abnormal_central_pattern0.38528656
76MP0001905_abnormal_dopamine_level0.37649322
77MP0001340_abnormal_eyelid_morphology0.35308511
78MP0003755_abnormal_palate_morphology0.34186155
79MP0006276_abnormal_autonomic_nervous0.32492762
80MP0006072_abnormal_retinal_apoptosis0.32460276
81MP0003123_paternal_imprinting0.30785613
82MP0004142_abnormal_muscle_tone0.28429420
83MP0004858_abnormal_nervous_system0.27856080
84MP0003938_abnormal_ear_development0.27680341
85MP0002272_abnormal_nervous_system0.26422037
86MP0002233_abnormal_nose_morphology0.26403517
87MP0005195_abnormal_posterior_eye0.25964291
88MP0001440_abnormal_grooming_behavior0.24844403
89MP0001851_eye_inflammation0.24710482
90MP0000631_abnormal_neuroendocrine_gland0.23994612
91MP0004130_abnormal_muscle_cell0.23933249
92MP0003763_abnormal_thymus_physiology0.23838262
93MP0002184_abnormal_innervation0.22965687
94MP0002822_catalepsy0.22931720
95MP0002138_abnormal_hepatobiliary_system0.22504482
96MP0002876_abnormal_thyroid_physiology0.21888026
97MP0002752_abnormal_somatic_nervous0.21853560
98MP0005535_abnormal_body_temperature0.21840426
99MP0001186_pigmentation_phenotype0.21643673
100MP0001756_abnormal_urination0.20429639

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.30610170
2Woolly hair (HP:0002224)9.04545137
3Hypotrichosis (HP:0001006)8.42967341
4Onycholysis (HP:0001806)8.23494066
5Increased IgE level (HP:0003212)8.19665996
6Erythroderma (HP:0001019)7.08040125
7Palmoplantar hyperkeratosis (HP:0000972)7.00571034
8Slow-growing hair (HP:0002217)6.85023273
9Abnormality of hair growth rate (HP:0011363)6.85023273
10Palmar hyperkeratosis (HP:0010765)6.64124713
11Abnormal hair laboratory examination (HP:0003328)6.28808309
12Brittle hair (HP:0002299)6.13382925
13Conjunctival hamartoma (HP:0100780)6.10753288
14Erythema (HP:0010783)5.93325955
15Abnormality of nail color (HP:0100643)5.84404622
16Plantar hyperkeratosis (HP:0007556)5.64753065
17Congenital ichthyosiform erythroderma (HP:0007431)5.39474895
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.84283815
19Abnormality of the axillary hair (HP:0100134)4.84002781
20Abnormality of secondary sexual hair (HP:0009888)4.84002781
21Absent eyelashes (HP:0000561)4.77676157
22Alopecia of scalp (HP:0002293)4.56021012
23Thick nail (HP:0001805)4.44033318
24Hamartoma of the eye (HP:0010568)4.18917953
25Absent hair (HP:0002298)3.95619343
26Dry hair (HP:0011359)3.91071706
27Parakeratosis (HP:0001036)3.86809717
28Nail dystrophy (HP:0008404)3.67246129
29Absent eyebrow (HP:0002223)3.57989789
30Fragile nails (HP:0001808)3.56157097
31Fine hair (HP:0002213)3.43880476
32Sparse eyelashes (HP:0000653)3.34647719
33Corneal erosion (HP:0200020)3.13985967
34Palmoplantar keratoderma (HP:0000982)3.11457498
35Abnormal blistering of the skin (HP:0008066)2.99259845
36Follicular hyperkeratosis (HP:0007502)2.90971117
37Congenital, generalized hypertrichosis (HP:0004540)2.89045157
38Hypohidrosis (HP:0000966)2.73088766
39Gangrene (HP:0100758)2.40692275
40Right ventricular cardiomyopathy (HP:0011663)2.32163398
41Sparse scalp hair (HP:0002209)2.19675871
42Furrowed tongue (HP:0000221)2.16935560
43Abnormality of the renal collecting system (HP:0004742)2.14943035
44Pruritus (HP:0000989)2.14400836
45Ridged nail (HP:0001807)2.13537915
46Oral leukoplakia (HP:0002745)2.10603911
47Hamartoma (HP:0010566)2.09297725
48Abnormality of the pupil (HP:0000615)2.07124930
49Lip pit (HP:0100267)1.98080662
50Milia (HP:0001056)1.94701159
51Hypergammaglobulinemia (HP:0010702)1.93406184
52Abnormality of the neuromuscular junction (HP:0003398)1.91608486
53Fatigable weakness (HP:0003473)1.91608486
54Blepharitis (HP:0000498)1.89060901
55Melanocytic nevus (HP:0000995)1.85273346
56Duplicated collecting system (HP:0000081)1.63909874
57Nasolacrimal duct obstruction (HP:0000579)1.63637683
58Congenital stationary night blindness (HP:0007642)1.62622433
59Conical tooth (HP:0000698)1.61280827
60Abnormality of permanent molar morphology (HP:0011071)1.55537075
61Abnormality of the dental root (HP:0006486)1.55537075
62Taurodontia (HP:0000679)1.55537075
63Oligodontia (HP:0000677)1.53749518
64Myokymia (HP:0002411)1.53370112
65Ectropion (HP:0000656)1.47211934
66Abnormality of the salivary glands (HP:0010286)1.43997747
67Stenosis of the external auditory canal (HP:0000402)1.43746562
68Abnormality of molar (HP:0011077)1.41528187
69Abnormality of molar morphology (HP:0011070)1.41528187
70Hypoplastic labia majora (HP:0000059)1.39161816
71Reticulocytopenia (HP:0001896)1.36580532
72Abnormality of the dental pulp (HP:0006479)1.36522648
73Acanthosis nigricans (HP:0000956)1.34794315
74Pendular nystagmus (HP:0012043)1.34366157
75Aplasia involving bones of the extremities (HP:0009825)1.32611907
76Aplasia involving bones of the upper limbs (HP:0009823)1.32611907
77Aplasia of the phalanges of the hand (HP:0009802)1.32611907
78Hyperhidrosis (HP:0000975)1.31610446
79Abnormality of the lacrimal duct (HP:0011481)1.31025742
80Abnormality of the costochondral junction (HP:0000919)1.30897351
81Abnormality of the labia majora (HP:0012881)1.29233167
82Abnormality of the middle phalanges of the toes (HP:0010183)1.25751034
83Dry skin (HP:0000958)1.25203484
84Coarse hair (HP:0002208)1.23585281
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.21738603
86Recurrent corneal erosions (HP:0000495)1.21198066
87Concave nail (HP:0001598)1.20648408
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.20229341
89Abnormal rod and cone electroretinograms (HP:0008323)1.19904067
90Adrenal hypoplasia (HP:0000835)1.18710017
91Neonatal onset (HP:0003623)1.18647394
92Ventricular fibrillation (HP:0001663)1.15606927
93Advanced eruption of teeth (HP:0006288)1.15515380
94Natal tooth (HP:0000695)1.13910408
95Hyperglycinemia (HP:0002154)1.13540403
96Renal dysplasia (HP:0000110)1.12756774
97Dehydration (HP:0001944)1.12675738
98Ventricular tachycardia (HP:0004756)1.11234111
99Abnormality of cells of the erythroid lineage (HP:0012130)1.10759696
100Septate vagina (HP:0001153)1.08747496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR13.46982902
2MAPKAPK33.25385154
3MAP3K62.99551516
4BCKDK2.66587939
5EPHB22.59688032
6FRK2.58599030
7PINK12.46940383
8STK392.38833172
9STK242.36873426
10ADRBK22.19896433
11CASK2.17263431
12GRK12.03134544
13WNK42.02095266
14EEF2K1.97403362
15CDK191.97141169
16SGK2231.79307352
17SGK4941.79307352
18MAPK131.75971553
19MAPKAPK51.69031627
20DYRK21.65928284
21FER1.63880734
22NTRK21.61005318
23RPS6KB21.56089997
24TYRO31.49169600
25TIE11.43477495
26OXSR11.43277420
27PIK3CA1.42372993
28KIT1.41530963
29FGFR11.40695700
30SGK21.37444256
31MAP2K61.31696493
32BMPR1B1.29459526
33ADRBK11.28134486
34MARK11.27840315
35FGFR31.23403683
36EPHA41.21571608
37PIK3CG1.17575111
38MAP3K91.11656214
39RPS6KB11.08693434
40MINK11.08602882
41FGFR21.06854178
42NTRK31.06434390
43INSRR1.06392928
44MAPK121.02509167
45MAP4K21.02148429
46PRKCG1.00574771
47MAP2K40.99448636
48SGK10.93648660
49MAPK70.93373383
50WNK30.89464750
51IKBKB0.88789675
52TAOK30.86182303
53NUAK10.81028265
54STK110.80418763
55PRKD20.78676527
56PRKCE0.77701692
57DYRK1B0.77530571
58MAP3K40.77111502
59RPS6KA20.76500257
60PRKACA0.75138727
61ABL20.74046580
62NLK0.73860446
63STK160.72700414
64SGK30.72482560
65MARK20.68171480
66LRRK20.67590161
67STK30.66435221
68MAP3K70.63806281
69CAMK10.62664388
70RPS6KA60.57047510
71CSNK1A10.56195170
72PRKCZ0.49722828
73CDK30.49434610
74TRPM70.48250086
75PRKCH0.47463678
76CSNK1E0.46930151
77PRKCD0.46623177
78DYRK1A0.46430435
79FES0.46423413
80PRKD30.46224996
81PRKCQ0.44733435
82ILK0.44677675
83PHKG20.44224367
84PHKG10.44224367
85ACVR1B0.44009740
86DMPK0.43742284
87MAP2K70.43172060
88PRKAA20.42384369
89ERBB20.40494725
90MAP2K20.40466740
91PRKCA0.39824010
92TEC0.39373193
93RPS6KC10.39217093
94RPS6KL10.39217093
95PRKCI0.38067679
96TXK0.36700875
97PAK30.35669997
98CDK50.35212532
99MAPKAPK20.34713163
100HIPK20.33819189

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.75183312
2Fatty acid elongation_Homo sapiens_hsa000624.77541930
3Linoleic acid metabolism_Homo sapiens_hsa005914.12164873
4Phototransduction_Homo sapiens_hsa047443.43538008
5Vitamin digestion and absorption_Homo sapiens_hsa049772.75949820
6Ether lipid metabolism_Homo sapiens_hsa005652.70884557
7Arachidonic acid metabolism_Homo sapiens_hsa005902.58440477
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27240313
9Ribosome_Homo sapiens_hsa030102.25953584
10Fatty acid biosynthesis_Homo sapiens_hsa000612.23245678
11Retinol metabolism_Homo sapiens_hsa008302.20457249
12Histidine metabolism_Homo sapiens_hsa003401.90138669
13Fatty acid metabolism_Homo sapiens_hsa012121.55613753
14Steroid biosynthesis_Homo sapiens_hsa001001.53833737
15beta-Alanine metabolism_Homo sapiens_hsa004101.53326512
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52900230
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51033858
18Olfactory transduction_Homo sapiens_hsa047401.44398840
19Fat digestion and absorption_Homo sapiens_hsa049751.43439878
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40934455
21Serotonergic synapse_Homo sapiens_hsa047261.36963102
22Oxidative phosphorylation_Homo sapiens_hsa001901.36040853
23Ovarian steroidogenesis_Homo sapiens_hsa049131.35235513
24Glycerolipid metabolism_Homo sapiens_hsa005611.27721659
25Phenylalanine metabolism_Homo sapiens_hsa003601.22647931
26Fatty acid degradation_Homo sapiens_hsa000711.20401897
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.18306957
28Nitrogen metabolism_Homo sapiens_hsa009101.12175973
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.12143224
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09424201
31Sphingolipid metabolism_Homo sapiens_hsa006001.08390974
32Renin secretion_Homo sapiens_hsa049241.07166403
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06086434
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04643145
35Peroxisome_Homo sapiens_hsa041461.02677850
36Butanoate metabolism_Homo sapiens_hsa006501.02105257
37Glutamatergic synapse_Homo sapiens_hsa047240.98126093
38Circadian entrainment_Homo sapiens_hsa047130.96927969
39GnRH signaling pathway_Homo sapiens_hsa049120.95850861
40Salivary secretion_Homo sapiens_hsa049700.95822869
41Long-term depression_Homo sapiens_hsa047300.94112380
42PPAR signaling pathway_Homo sapiens_hsa033200.93292232
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.93042932
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92569168
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.92496964
46Nicotine addiction_Homo sapiens_hsa050330.91581021
47Tryptophan metabolism_Homo sapiens_hsa003800.90802418
48Cardiac muscle contraction_Homo sapiens_hsa042600.86495546
49Alzheimers disease_Homo sapiens_hsa050100.85688963
50Collecting duct acid secretion_Homo sapiens_hsa049660.85239622
51Chemical carcinogenesis_Homo sapiens_hsa052040.82488863
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78206224
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77752749
54Tyrosine metabolism_Homo sapiens_hsa003500.77441265
55Axon guidance_Homo sapiens_hsa043600.76920095
56Dorso-ventral axis formation_Homo sapiens_hsa043200.76603530
57Parkinsons disease_Homo sapiens_hsa050120.75297961
58Sulfur relay system_Homo sapiens_hsa041220.74095663
59Ras signaling pathway_Homo sapiens_hsa040140.73232601
60Gastric acid secretion_Homo sapiens_hsa049710.72766189
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71050648
62Dopaminergic synapse_Homo sapiens_hsa047280.70554909
63Oxytocin signaling pathway_Homo sapiens_hsa049210.69859989
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68363594
65Taste transduction_Homo sapiens_hsa047420.67322925
66Amphetamine addiction_Homo sapiens_hsa050310.64628475
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.58575885
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57647927
69Staphylococcus aureus infection_Homo sapiens_hsa051500.56940359
70Propanoate metabolism_Homo sapiens_hsa006400.55712124
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54811325
72Calcium signaling pathway_Homo sapiens_hsa040200.53394999
73Long-term potentiation_Homo sapiens_hsa047200.52713536
74Pancreatic secretion_Homo sapiens_hsa049720.51744280
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50287934
76VEGF signaling pathway_Homo sapiens_hsa043700.49654510
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.46757802
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46431425
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46076477
80Morphine addiction_Homo sapiens_hsa050320.44122220
81Melanogenesis_Homo sapiens_hsa049160.41393882
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39483261
83Basal cell carcinoma_Homo sapiens_hsa052170.39472399
84Insulin secretion_Homo sapiens_hsa049110.38760913
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38640641
86Hedgehog signaling pathway_Homo sapiens_hsa043400.37413201
87cAMP signaling pathway_Homo sapiens_hsa040240.32305494
88Pyruvate metabolism_Homo sapiens_hsa006200.31017699
89Huntingtons disease_Homo sapiens_hsa050160.29853132
90Metabolic pathways_Homo sapiens_hsa011000.28846447
91Synaptic vesicle cycle_Homo sapiens_hsa047210.28481200
92Protein digestion and absorption_Homo sapiens_hsa049740.27152611
93Arginine and proline metabolism_Homo sapiens_hsa003300.25101893
94GABAergic synapse_Homo sapiens_hsa047270.24695572
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23300742
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22596832
97ECM-receptor interaction_Homo sapiens_hsa045120.18444456
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17367133
99Mineral absorption_Homo sapiens_hsa049780.17088741
100MAPK signaling pathway_Homo sapiens_hsa040100.16570911

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