ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fatty acid elongation (GO:0030497)	9.33828920
2	desmosome organization (GO:0002934)	9.02790597
3	regulation of water loss via skin (GO:0033561)	8.85610324
4	intermediate filament cytoskeleton organization (GO:0045104)	7.72939288
5	intermediate filament-based process (GO:0045103)	7.50616896
6	hair follicle morphogenesis (GO:0031069)	7.20069031
7	linoleic acid metabolic process (GO:0043651)	6.41414817
8	epidermis development (GO:0008544)	6.26673746
9	keratinocyte differentiation (GO:0030216)	6.19332683
10	peptide cross-linking (GO:0018149)	6.07872963
11	keratinocyte proliferation (GO:0043616)	5.82307590
12	multicellular organismal water homeostasis (GO:0050891)	5.82026165
13	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.20609838
14	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.18464312
15	long-chain fatty acid biosynthetic process (GO:0042759)	5.02112111
16	water homeostasis (GO:0030104)	4.98451336
17	epidermal cell differentiation (GO:0009913)	4.90532093
18	retinol metabolic process (GO:0042572)	4.84377711
19	very long-chain fatty acid metabolic process (GO:0000038)	4.47869514
20	molting cycle process (GO:0022404)	4.42351359
21	hair cycle process (GO:0022405)	4.42351359
22	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	4.42228179
23	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	4.30183273
24	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.23720669
25	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	4.02565260
26	lipoxygenase pathway (GO:0019372)	3.96446995
27	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.86720526
28	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.85528251
29	primary alcohol metabolic process (GO:0034308)	3.66986490
30	regulation of sequestering of triglyceride (GO:0010889)	3.56055151
31	fatty-acyl-CoA metabolic process (GO:0035337)	3.51302072
32	positive regulation of chemokine secretion (GO:0090197)	3.49876399
33	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.45383531
34	hemidesmosome assembly (GO:0031581)	3.20574565
35	behavioral response to nicotine (GO:0035095)	3.18238297
36	thioester biosynthetic process (GO:0035384)	3.13972702
37	acyl-CoA biosynthetic process (GO:0071616)	3.13972702
38	viral transcription (GO:0019083)	3.13281606
39	epithelium development (GO:0060429)	3.08523728
40	keratinocyte development (GO:0003334)	3.08171597
41	regulation of chemokine secretion (GO:0090196)	3.06754901
42	molting cycle (GO:0042303)	22.6078307
43	hair cycle (GO:0042633)	22.6078307
44	lateral sprouting from an epithelium (GO:0060601)	2.98462604
45	translational termination (GO:0006415)	2.95961788
46	positive regulation of keratinocyte differentiation (GO:0045618)	2.89550415
47	phosphatidylserine metabolic process (GO:0006658)	2.89480063
48	response to phenylpropanoid (GO:0080184)	2.88465182
49	adhesion of symbiont to host cell (GO:0044650)	2.87684518
50	virion attachment to host cell (GO:0019062)	2.87684518
51	primary alcohol catabolic process (GO:0034310)	2.86848384
52	ribosomal small subunit biogenesis (GO:0042274)	2.83321319
53	one-carbon compound transport (GO:0019755)	2.76566424
54	phospholipid catabolic process (GO:0009395)	2.69202698
55	establishment of planar polarity (GO:0001736)	2.68533282
56	establishment of tissue polarity (GO:0007164)	2.68533282
57	ribosomal small subunit assembly (GO:0000028)	2.66870190
58	parturition (GO:0007567)	2.57941660
59	cell proliferation in forebrain (GO:0021846)	2.57219866
60	negative regulation of keratinocyte proliferation (GO:0010839)	2.53222821
61	positive regulation of epidermal cell differentiation (GO:0045606)	2.52891464
62	regulation of keratinocyte differentiation (GO:0045616)	2.48790774
63	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.46546148
64	unsaturated fatty acid biosynthetic process (GO:0006636)	2.40515772
65	translational elongation (GO:0006414)	2.40335513
66	phosphatidylglycerol metabolic process (GO:0046471)	2.35007391
67	triglyceride biosynthetic process (GO:0019432)	2.34885062
68	regulation of heart rate by cardiac conduction (GO:0086091)	2.34714553
69	central nervous system myelination (GO:0022010)	2.32417679
70	axon ensheathment in central nervous system (GO:0032291)	2.32417679
71	acylglycerol biosynthetic process (GO:0046463)	2.28010559
72	neutral lipid biosynthetic process (GO:0046460)	2.28010559
73	hair follicle development (GO:0001942)	2.27400968
74	adhesion of symbiont to host (GO:0044406)	2.27136452
75	icosanoid secretion (GO:0032309)	2.26772718
76	arachidonic acid secretion (GO:0050482)	2.26772718
77	glandular epithelial cell differentiation (GO:0002067)	2.26286159
78	fatty acid biosynthetic process (GO:0006633)	2.26265019
79	viral life cycle (GO:0019058)	2.26185443
80	ethanol metabolic process (GO:0006067)	2.23906914
81	carnitine metabolic process (GO:0009437)	2.21578545
82	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.18936601
83	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.16016665
84	substrate-independent telencephalic tangential migration (GO:0021826)	2.16016665
85	cotranslational protein targeting to membrane (GO:0006613)	2.15875424
86	protein targeting to ER (GO:0045047)	2.15328532
87	epithelial cell fate commitment (GO:0072148)	2.14250165
88	alditol phosphate metabolic process (GO:0052646)	2.13530323
89	ectoderm development (GO:0007398)	2.12249897
90	positive regulation of epidermis development (GO:0045684)	2.10421853
91	regulation of phospholipase A2 activity (GO:0032429)	2.10161480
92	acyl-CoA metabolic process (GO:0006637)	2.10028686
93	thioester metabolic process (GO:0035383)	2.10028686
94	alpha-linolenic acid metabolic process (GO:0036109)	2.07266831
95	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.07185006
96	phosphatidic acid biosynthetic process (GO:0006654)	2.07020588
97	phosphatidic acid metabolic process (GO:0046473)	2.07020588
98	keratinization (GO:0031424)	12.7366045
99	intermediate filament organization (GO:0045109)	12.0980715
100	establishment of skin barrier (GO:0061436)	10.7453568

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	8.02895503
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	7.39986017
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.41765582
4	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.08470496
5	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.55781670
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.32936498
7	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.19275975
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.16616865
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.07176288
10	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.02422338
11	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.01123845
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93143546
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.83704883
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70226330
15	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.66639495
16	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.66113198
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66112575
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65390328
19	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.60722651
20	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.55346966
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.55346966
22	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.52678621
23	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.52578849
24	CTCF_20526341_ChIP-Seq_ESCs_Human	1.51581691
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51444374
26	CTCF_27219007_Chip-Seq_Bcells_Human	1.50742964
27	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.47672119
28	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.45131851
29	RXR_22108803_ChIP-Seq_LS180_Human	1.43944275
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41436312
31	TP63_22573176_ChIP-Seq_HFKS_Human	1.41113636
32	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.36272602
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32629555
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.31413929
35	TP63_23658742_ChIP-Seq_EP156T_Human	1.30716390
36	NCOR_22424771_ChIP-Seq_293T_Human	1.30270282
37	* ERG_20517297_ChIP-Seq_VCAP_Human	1.29795885
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.29476093
39	VDR_22108803_ChIP-Seq_LS180_Human	1.28025675
40	* FOXH1_21741376_ChIP-Seq_ESCs_Human	1.27861717
41	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.26781150
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.26524880
43	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.24961042
44	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.24375121
45	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23097520
46	P53_21459846_ChIP-Seq_SAOS-2_Human	1.22534766
47	* E2F1_20622854_ChIP-Seq_HELA_Human	1.20944923
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.20591038
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19182284
50	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17998340
51	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17998340
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15829686
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15829686
54	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.15714681
55	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.14966089
56	* BCL6_27268052_Chip-Seq_Bcells_Human	1.14826132
57	ZNF274_21170338_ChIP-Seq_K562_Hela	1.11056747
58	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10946146
59	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.10487545
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.07045360
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06329173
62	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.05642647
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05359921
64	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.04213667
65	ERA_21632823_ChIP-Seq_H3396_Human	1.03113546
66	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01627316
67	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99597074
68	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98369713
69	CBP_20019798_ChIP-Seq_JUKART_Human	0.97788356
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97788356
71	AR_25329375_ChIP-Seq_VCAP_Human	0.97266960
72	P68_20966046_ChIP-Seq_HELA_Human	0.97069977
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96990652
74	* YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96327898
75	MYC_19829295_ChIP-Seq_ESCs_Human	0.96204059
76	* BCOR_27268052_Chip-Seq_Bcells_Human	0.94188356
77	GBX2_23144817_ChIP-Seq_PC3_Human	0.94146203
78	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92490528
79	* FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90526368
80	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.90026309
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89906743
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.89283293
83	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89149498
84	PHF8_20622853_ChIP-Seq_HELA_Human	0.89113362
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.88905103
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.88016319
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87558034
88	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.86868052
89	FUS_26573619_Chip-Seq_HEK293_Human	0.85159704
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.83957258
91	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.82179893
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.82009312
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.81800969
94	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81643735
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.80591279
96	* OCT4_20526341_ChIP-Seq_ESCs_Human	0.80484995
97	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.78814425
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.77447301
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77310230
100	TP53_18474530_ChIP-ChIP_U2OS_Human	0.77103663

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.04938974
2	MP0002796_impaired_skin_barrier	6.12476811
3	MP0005275_abnormal_skin_tensile	5.90419584
4	MP0000647_abnormal_sebaceous_gland	5.65590260
5	MP0004381_abnormal_hair_follicle	4.66659355
6	MP0000579_abnormal_nail_morphology	4.54533457
7	MP0002098_abnormal_vibrissa_morphology	4.54491147
8	MP0010234_abnormal_vibrissa_follicle	3.56519895
9	MP0001188_hyperpigmentation	3.53749929
10	MP0005501_abnormal_skin_physiology	3.39851928
11	MP0000377_abnormal_hair_follicle	3.03505579
12	MP0000383_abnormal_hair_follicle	2.65386195
13	MP0002095_abnormal_skin_pigmentation	2.57946731
14	MP0005075_abnormal_melanosome_morpholog	2.43559469
15	MP0010678_abnormal_skin_adnexa	2.41977123
16	MP0004885_abnormal_endolymph	2.41763096
17	MP0001216_abnormal_epidermal_layer	2.31449207
18	MP0003011_delayed_dark_adaptation	2.28663830
19	MP0004947_skin_inflammation	2.17120475
20	MP0000566_synostosis	2.11603324
21	MP0003453_abnormal_keratinocyte_physiol	2.10583559
22	MP0010771_integument_phenotype	2.10167936
23	MP0000427_abnormal_hair_cycle	2.03839086
24	MP0005377_hearing/vestibular/ear_phenot	2.03053153
25	MP0003878_abnormal_ear_physiology	2.03053153
26	MP0005409_darkened_coat_color	1.96293562
27	MP0000367_abnormal_coat/_hair	1.83603229
28	MP0002060_abnormal_skin_morphology	1.81512588
29	MP0005174_abnormal_tail_pigmentation	1.66690090
30	MP0000015_abnormal_ear_pigmentation	1.61511661
31	MP0003705_abnormal_hypodermis_morpholog	1.35811135
32	MP0006292_abnormal_olfactory_placode	1.31993188
33	MP0009931_abnormal_skin_appearance	1.29979094
34	MP0000467_abnormal_esophagus_morphology	1.24830918
35	MP0001243_abnormal_dermal_layer	1.19370116
36	MP0005646_abnormal_pituitary_gland	1.07620056
37	MP0005647_abnormal_sex_gland	1.02562736
38	MP0001984_abnormal_olfaction	0.94907541
39	MP0003646_muscle_fatigue	0.94843683
40	MP0008789_abnormal_olfactory_epithelium	0.89889407
41	MP0001191_abnormal_skin_condition	0.89002662
42	MP0001485_abnormal_pinna_reflex	0.84250932
43	MP0002163_abnormal_gland_morphology	0.82272443
44	MP0010030_abnormal_orbit_morphology	0.76757007
45	MP0002282_abnormal_trachea_morphology	0.74543511
46	MP0009053_abnormal_anal_canal	0.71779837
47	MP0000762_abnormal_tongue_morphology	0.69812114
48	MP0002177_abnormal_outer_ear	0.68967001
49	MP0005394_taste/olfaction_phenotype	0.68414722
50	MP0005499_abnormal_olfactory_system	0.68414722
51	MP0002837_dystrophic_cardiac_calcinosis	0.64800884
52	MP0005551_abnormal_eye_electrophysiolog	0.64596585
53	MP0003941_abnormal_skin_development	0.63194498
54	MP0002653_abnormal_ependyma_morphology	0.61521525
55	MP0004742_abnormal_vestibular_system	0.60317130
56	MP0004782_abnormal_surfactant_physiolog	0.59705721
57	MP0002234_abnormal_pharynx_morphology	0.58996982
58	MP0000049_abnormal_middle_ear	0.56784579
59	MP0005389_reproductive_system_phenotype	0.56182261
60	MP0002249_abnormal_larynx_morphology	0.56175311
61	MP0001919_abnormal_reproductive_system	0.53376201
62	MP0002638_abnormal_pupillary_reflex	0.50789228
63	MP0009780_abnormal_chondrocyte_physiolo	0.49233001
64	MP0003638_abnormal_response/metabolism_	0.48381129
65	MP0005379_endocrine/exocrine_gland_phen	0.48113736
66	MP0002160_abnormal_reproductive_system	0.48031067
67	MP0000778_abnormal_nervous_system	0.44708588
68	MP0001784_abnormal_fluid_regulation	0.44543771
69	MP0000678_abnormal_parathyroid_gland	0.42944405
70	MP0004019_abnormal_vitamin_homeostasis	0.42598409
71	MP0003787_abnormal_imprinting	0.41679231
72	MP0006035_abnormal_mitochondrial_morpho	0.41580555
73	MP0005423_abnormal_somatic_nervous	0.40955743
74	MP0000026_abnormal_inner_ear	0.40250548
75	MP0003880_abnormal_central_pattern	0.38528656
76	MP0001905_abnormal_dopamine_level	0.37649322
77	MP0001340_abnormal_eyelid_morphology	0.35308511
78	MP0003755_abnormal_palate_morphology	0.34186155
79	MP0006276_abnormal_autonomic_nervous	0.32492762
80	MP0006072_abnormal_retinal_apoptosis	0.32460276
81	MP0003123_paternal_imprinting	0.30785613
82	MP0004142_abnormal_muscle_tone	0.28429420
83	MP0004858_abnormal_nervous_system	0.27856080
84	MP0003938_abnormal_ear_development	0.27680341
85	MP0002272_abnormal_nervous_system	0.26422037
86	MP0002233_abnormal_nose_morphology	0.26403517
87	MP0005195_abnormal_posterior_eye	0.25964291
88	MP0001440_abnormal_grooming_behavior	0.24844403
89	MP0001851_eye_inflammation	0.24710482
90	MP0000631_abnormal_neuroendocrine_gland	0.23994612
91	MP0004130_abnormal_muscle_cell	0.23933249
92	MP0003763_abnormal_thymus_physiology	0.23838262
93	MP0002184_abnormal_innervation	0.22965687
94	MP0002822_catalepsy	0.22931720
95	MP0002138_abnormal_hepatobiliary_system	0.22504482
96	MP0002876_abnormal_thyroid_physiology	0.21888026
97	MP0002752_abnormal_somatic_nervous	0.21853560
98	MP0005535_abnormal_body_temperature	0.21840426
99	MP0001186_pigmentation_phenotype	0.21643673
100	MP0001756_abnormal_urination	0.20429639

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.30610170
2	Woolly hair (HP:0002224)	9.04545137
3	Hypotrichosis (HP:0001006)	8.42967341
4	Onycholysis (HP:0001806)	8.23494066
5	Increased IgE level (HP:0003212)	8.19665996
6	Erythroderma (HP:0001019)	7.08040125
7	Palmoplantar hyperkeratosis (HP:0000972)	7.00571034
8	Slow-growing hair (HP:0002217)	6.85023273
9	Abnormality of hair growth rate (HP:0011363)	6.85023273
10	Palmar hyperkeratosis (HP:0010765)	6.64124713
11	Abnormal hair laboratory examination (HP:0003328)	6.28808309
12	Brittle hair (HP:0002299)	6.13382925
13	Conjunctival hamartoma (HP:0100780)	6.10753288
14	Erythema (HP:0010783)	5.93325955
15	Abnormality of nail color (HP:0100643)	5.84404622
16	Plantar hyperkeratosis (HP:0007556)	5.64753065
17	Congenital ichthyosiform erythroderma (HP:0007431)	5.39474895
18	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.84283815
19	Abnormality of the axillary hair (HP:0100134)	4.84002781
20	Abnormality of secondary sexual hair (HP:0009888)	4.84002781
21	Absent eyelashes (HP:0000561)	4.77676157
22	Alopecia of scalp (HP:0002293)	4.56021012
23	Thick nail (HP:0001805)	4.44033318
24	Hamartoma of the eye (HP:0010568)	4.18917953
25	Absent hair (HP:0002298)	3.95619343
26	Dry hair (HP:0011359)	3.91071706
27	Parakeratosis (HP:0001036)	3.86809717
28	Nail dystrophy (HP:0008404)	3.67246129
29	Absent eyebrow (HP:0002223)	3.57989789
30	Fragile nails (HP:0001808)	3.56157097
31	Fine hair (HP:0002213)	3.43880476
32	Sparse eyelashes (HP:0000653)	3.34647719
33	Corneal erosion (HP:0200020)	3.13985967
34	Palmoplantar keratoderma (HP:0000982)	3.11457498
35	Abnormal blistering of the skin (HP:0008066)	2.99259845
36	Follicular hyperkeratosis (HP:0007502)	2.90971117
37	Congenital, generalized hypertrichosis (HP:0004540)	2.89045157
38	Hypohidrosis (HP:0000966)	2.73088766
39	Gangrene (HP:0100758)	2.40692275
40	Right ventricular cardiomyopathy (HP:0011663)	2.32163398
41	Sparse scalp hair (HP:0002209)	2.19675871
42	Furrowed tongue (HP:0000221)	2.16935560
43	Abnormality of the renal collecting system (HP:0004742)	2.14943035
44	Pruritus (HP:0000989)	2.14400836
45	Ridged nail (HP:0001807)	2.13537915
46	Oral leukoplakia (HP:0002745)	2.10603911
47	Hamartoma (HP:0010566)	2.09297725
48	Abnormality of the pupil (HP:0000615)	2.07124930
49	Lip pit (HP:0100267)	1.98080662
50	Milia (HP:0001056)	1.94701159
51	Hypergammaglobulinemia (HP:0010702)	1.93406184
52	Abnormality of the neuromuscular junction (HP:0003398)	1.91608486
53	Fatigable weakness (HP:0003473)	1.91608486
54	Blepharitis (HP:0000498)	1.89060901
55	Melanocytic nevus (HP:0000995)	1.85273346
56	Duplicated collecting system (HP:0000081)	1.63909874
57	Nasolacrimal duct obstruction (HP:0000579)	1.63637683
58	Congenital stationary night blindness (HP:0007642)	1.62622433
59	Conical tooth (HP:0000698)	1.61280827
60	Abnormality of the dental root (HP:0006486)	1.55537075
61	Taurodontia (HP:0000679)	1.55537075
62	Abnormality of permanent molar morphology (HP:0011071)	1.55537075
63	Oligodontia (HP:0000677)	1.53749518
64	Myokymia (HP:0002411)	1.53370112
65	Ectropion (HP:0000656)	1.47211934
66	Abnormality of the salivary glands (HP:0010286)	1.43997747
67	Stenosis of the external auditory canal (HP:0000402)	1.43746562
68	Abnormality of molar (HP:0011077)	1.41528187
69	Abnormality of molar morphology (HP:0011070)	1.41528187
70	Hypoplastic labia majora (HP:0000059)	1.39161816
71	Reticulocytopenia (HP:0001896)	1.36580532
72	Abnormality of the dental pulp (HP:0006479)	1.36522648
73	Acanthosis nigricans (HP:0000956)	1.34794315
74	Pendular nystagmus (HP:0012043)	1.34366157
75	Aplasia involving bones of the extremities (HP:0009825)	1.32611907
76	Aplasia involving bones of the upper limbs (HP:0009823)	1.32611907
77	Aplasia of the phalanges of the hand (HP:0009802)	1.32611907
78	Hyperhidrosis (HP:0000975)	1.31610446
79	Abnormality of the lacrimal duct (HP:0011481)	1.31025742
80	Abnormality of the costochondral junction (HP:0000919)	1.30897351
81	Abnormality of the labia majora (HP:0012881)	1.29233167
82	Abnormality of the middle phalanges of the toes (HP:0010183)	1.25751034
83	Dry skin (HP:0000958)	1.25203484
84	Coarse hair (HP:0002208)	1.23585281
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.21738603
86	Recurrent corneal erosions (HP:0000495)	1.21198066
87	Concave nail (HP:0001598)	1.20648408
88	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.20229341
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.19904067
90	Adrenal hypoplasia (HP:0000835)	1.18710017
91	Neonatal onset (HP:0003623)	1.18647394
92	Ventricular fibrillation (HP:0001663)	1.15606927
93	Advanced eruption of teeth (HP:0006288)	1.15515380
94	Natal tooth (HP:0000695)	1.13910408
95	Hyperglycinemia (HP:0002154)	1.13540403
96	Renal dysplasia (HP:0000110)	1.12756774
97	Dehydration (HP:0001944)	1.12675738
98	Ventricular tachycardia (HP:0004756)	1.11234111
99	Abnormality of cells of the erythroid lineage (HP:0012130)	1.10759696
100	Septate vagina (HP:0001153)	1.08747496

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TGFBR1	3.46982902
2	MAPKAPK3	3.25385154
3	MAP3K6	2.99551516
4	BCKDK	2.66587939
5	EPHB2	2.59688032
6	FRK	2.58599030
7	PINK1	2.46940383
8	STK39	2.38833172
9	STK24	2.36873426
10	ADRBK2	2.19896433
11	CASK	2.17263431
12	GRK1	2.03134544
13	WNK4	2.02095266
14	EEF2K	1.97403362
15	CDK19	1.97141169
16	SGK223	1.79307352
17	SGK494	1.79307352
18	MAPK13	1.75971553
19	MAPKAPK5	1.69031627
20	DYRK2	1.65928284
21	FER	1.63880734
22	NTRK2	1.61005318
23	RPS6KB2	1.56089997
24	TYRO3	1.49169600
25	TIE1	1.43477495
26	OXSR1	1.43277420
27	PIK3CA	1.42372993
28	KIT	1.41530963
29	FGFR1	1.40695700
30	SGK2	1.37444256
31	MAP2K6	1.31696493
32	BMPR1B	1.29459526
33	ADRBK1	1.28134486
34	MARK1	1.27840315
35	FGFR3	1.23403683
36	EPHA4	1.21571608
37	PIK3CG	1.17575111
38	MAP3K9	1.11656214
39	RPS6KB1	1.08693434
40	MINK1	1.08602882
41	FGFR2	1.06854178
42	NTRK3	1.06434390
43	INSRR	1.06392928
44	MAPK12	1.02509167
45	MAP4K2	1.02148429
46	PRKCG	1.00574771
47	MAP2K4	0.99448636
48	SGK1	0.93648660
49	MAPK7	0.93373383
50	WNK3	0.89464750
51	IKBKB	0.88789675
52	TAOK3	0.86182303
53	NUAK1	0.81028265
54	STK11	0.80418763
55	PRKD2	0.78676527
56	PRKCE	0.77701692
57	DYRK1B	0.77530571
58	MAP3K4	0.77111502
59	RPS6KA2	0.76500257
60	PRKACA	0.75138727
61	ABL2	0.74046580
62	NLK	0.73860446
63	STK16	0.72700414
64	SGK3	0.72482560
65	MARK2	0.68171480
66	LRRK2	0.67590161
67	STK3	0.66435221
68	MAP3K7	0.63806281
69	CAMK1	0.62664388
70	RPS6KA6	0.57047510
71	CSNK1A1	0.56195170
72	PRKCZ	0.49722828
73	CDK3	0.49434610
74	TRPM7	0.48250086
75	PRKCH	0.47463678
76	CSNK1E	0.46930151
77	PRKCD	0.46623177
78	DYRK1A	0.46430435
79	FES	0.46423413
80	PRKD3	0.46224996
81	PRKCQ	0.44733435
82	ILK	0.44677675
83	PHKG1	0.44224367
84	PHKG2	0.44224367
85	ACVR1B	0.44009740
86	DMPK	0.43742284
87	MAP2K7	0.43172060
88	PRKAA2	0.42384369
89	ERBB2	0.40494725
90	MAP2K2	0.40466740
91	PRKCA	0.39824010
92	TEC	0.39373193
93	RPS6KC1	0.39217093
94	RPS6KL1	0.39217093
95	PRKCI	0.38067679
96	TXK	0.36700875
97	PAK3	0.35669997
98	CDK5	0.35212532
99	MAPKAPK2	0.34713163
100	HIPK2	0.33819189

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	5.75183312
2	Fatty acid elongation_Homo sapiens_hsa00062	4.77541930
3	Linoleic acid metabolism_Homo sapiens_hsa00591	4.12164873
4	Phototransduction_Homo sapiens_hsa04744	3.43538008
5	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.75949820
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.70884557
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.58440477
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.27240313
9	Ribosome_Homo sapiens_hsa03010	2.25953584
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.23245678
11	Retinol metabolism_Homo sapiens_hsa00830	2.20457249
12	Histidine metabolism_Homo sapiens_hsa00340	1.90138669
13	Fatty acid metabolism_Homo sapiens_hsa01212	1.55613753
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.53833737
15	beta-Alanine metabolism_Homo sapiens_hsa00410	1.53326512
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52900230
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51033858
18	Olfactory transduction_Homo sapiens_hsa04740	1.44398840
19	Fat digestion and absorption_Homo sapiens_hsa04975	1.43439878
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.40934455
21	Serotonergic synapse_Homo sapiens_hsa04726	1.36963102
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36040853
23	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.35235513
24	Glycerolipid metabolism_Homo sapiens_hsa00561	1.27721659
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.22647931
26	Fatty acid degradation_Homo sapiens_hsa00071	1.20401897
27	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.18306957
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.12175973
29	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.12143224
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09424201
31	Sphingolipid metabolism_Homo sapiens_hsa00600	1.08390974
32	Renin secretion_Homo sapiens_hsa04924	1.07166403
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06086434
34	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.04643145
35	Peroxisome_Homo sapiens_hsa04146	1.02677850
36	Butanoate metabolism_Homo sapiens_hsa00650	1.02105257
37	Glutamatergic synapse_Homo sapiens_hsa04724	0.98126093
38	Circadian entrainment_Homo sapiens_hsa04713	0.96927969
39	GnRH signaling pathway_Homo sapiens_hsa04912	0.95850861
40	Salivary secretion_Homo sapiens_hsa04970	0.95822869
41	Long-term depression_Homo sapiens_hsa04730	0.94112380
42	PPAR signaling pathway_Homo sapiens_hsa03320	0.93292232
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93042932
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92569168
45	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92496964
46	Nicotine addiction_Homo sapiens_hsa05033	0.91581021
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.90802418
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86495546
49	Alzheimers disease_Homo sapiens_hsa05010	0.85688963
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85239622
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82488863
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78206224
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77752749
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.77441265
55	Axon guidance_Homo sapiens_hsa04360	0.76920095
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76603530
57	Parkinsons disease_Homo sapiens_hsa05012	0.75297961
58	Sulfur relay system_Homo sapiens_hsa04122	0.74095663
59	Ras signaling pathway_Homo sapiens_hsa04014	0.73232601
60	Gastric acid secretion_Homo sapiens_hsa04971	0.72766189
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.71050648
62	Dopaminergic synapse_Homo sapiens_hsa04728	0.70554909
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69859989
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68363594
65	Taste transduction_Homo sapiens_hsa04742	0.67322925
66	Amphetamine addiction_Homo sapiens_hsa05031	0.64628475
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58575885
68	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.57647927
69	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56940359
70	Propanoate metabolism_Homo sapiens_hsa00640	0.55712124
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54811325
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.53394999
73	Long-term potentiation_Homo sapiens_hsa04720	0.52713536
74	Pancreatic secretion_Homo sapiens_hsa04972	0.51744280
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50287934
76	VEGF signaling pathway_Homo sapiens_hsa04370	0.49654510
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46757802
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46431425
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46076477
80	Morphine addiction_Homo sapiens_hsa05032	0.44122220
81	Melanogenesis_Homo sapiens_hsa04916	0.41393882
82	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39483261
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.39472399
84	Insulin secretion_Homo sapiens_hsa04911	0.38760913
85	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.38640641
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37413201
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.32305494
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.31017699
89	Huntingtons disease_Homo sapiens_hsa05016	0.29853132
90	Metabolic pathways_Homo sapiens_hsa01100	0.28846447
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28481200
92	Protein digestion and absorption_Homo sapiens_hsa04974	0.27152611
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25101893
94	GABAergic synapse_Homo sapiens_hsa04727	0.24695572
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23300742
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.22596832
97	ECM-receptor interaction_Homo sapiens_hsa04512	0.18444456
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.17367133
99	Mineral absorption_Homo sapiens_hsa04978	0.17088741
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.16570911

DCD

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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