DCDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.08868402
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.22842806
3axonemal dynein complex assembly (GO:0070286)7.80452093
4cilium movement (GO:0003341)7.74586973
5epithelial cilium movement (GO:0003351)7.16282277
6axoneme assembly (GO:0035082)6.08544142
7motile cilium assembly (GO:0044458)5.60781031
8regulation of cilium movement (GO:0003352)5.13649461
9cilium organization (GO:0044782)4.51244640
10behavioral response to nicotine (GO:0035095)4.49199592
11intraciliary transport (GO:0042073)4.45039924
12cilium assembly (GO:0042384)4.34447007
13retinal cone cell development (GO:0046549)4.19463100
14cilium morphogenesis (GO:0060271)4.05711641
15photoreceptor cell maintenance (GO:0045494)3.90039373
16protein localization to cilium (GO:0061512)3.89112394
17left/right axis specification (GO:0070986)3.87938872
18fucose catabolic process (GO:0019317)3.77141606
19L-fucose metabolic process (GO:0042354)3.77141606
20L-fucose catabolic process (GO:0042355)3.77141606
21nonmotile primary cilium assembly (GO:0035058)3.71234440
22protein polyglutamylation (GO:0018095)3.70142201
23cellular ketone body metabolic process (GO:0046950)3.65599399
24indole-containing compound catabolic process (GO:0042436)3.61844441
25indolalkylamine catabolic process (GO:0046218)3.61844441
26tryptophan catabolic process (GO:0006569)3.61844441
27retinal rod cell development (GO:0046548)3.54768815
28response to pheromone (GO:0019236)3.51159431
29sperm motility (GO:0030317)3.50115932
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.47446021
31ventricular system development (GO:0021591)3.46664720
32cellular component assembly involved in morphogenesis (GO:0010927)3.46574744
33detection of light stimulus involved in sensory perception (GO:0050962)3.46532964
34detection of light stimulus involved in visual perception (GO:0050908)3.46532964
35kynurenine metabolic process (GO:0070189)3.38138758
36regulation of microtubule-based movement (GO:0060632)3.36177399
37indolalkylamine metabolic process (GO:0006586)3.34141675
38ketone body metabolic process (GO:1902224)3.27638602
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26150782
40microtubule bundle formation (GO:0001578)3.24266900
41piRNA metabolic process (GO:0034587)3.16076473
42photoreceptor cell development (GO:0042461)3.15841162
43neural tube formation (GO:0001841)3.09392741
44smoothened signaling pathway (GO:0007224)3.06975440
45cornea development in camera-type eye (GO:0061303)3.04945987
46tryptophan metabolic process (GO:0006568)3.01268537
47spinal cord motor neuron differentiation (GO:0021522)2.94443477
48neuronal action potential (GO:0019228)2.89054009
49eye photoreceptor cell development (GO:0042462)2.86278943
50determination of left/right symmetry (GO:0007368)2.85057174
51male meiosis I (GO:0007141)2.84984670
52multicellular organism reproduction (GO:0032504)2.79347996
53gamma-aminobutyric acid transport (GO:0015812)2.78398886
54left/right pattern formation (GO:0060972)2.77299303
55platelet dense granule organization (GO:0060155)2.74729129
56water-soluble vitamin biosynthetic process (GO:0042364)2.73385016
57indole-containing compound metabolic process (GO:0042430)2.70953348
58DNA methylation involved in gamete generation (GO:0043046)2.70412728
59cell projection assembly (GO:0030031)2.70050205
60determination of bilateral symmetry (GO:0009855)2.68602697
61transmission of nerve impulse (GO:0019226)2.68265007
62cellular biogenic amine catabolic process (GO:0042402)2.61654915
63amine catabolic process (GO:0009310)2.61654915
64appendage development (GO:0048736)2.61460152
65limb development (GO:0060173)2.61460152
66specification of symmetry (GO:0009799)2.60539735
67synapsis (GO:0007129)2.59792871
68kidney morphogenesis (GO:0060993)2.57727178
69exogenous drug catabolic process (GO:0042738)2.56283933
70nephron epithelium morphogenesis (GO:0072088)2.55029718
71nephron tubule morphogenesis (GO:0072078)2.55029718
72primary amino compound metabolic process (GO:1901160)2.53657333
73pyrimidine nucleobase catabolic process (GO:0006208)2.53650488
74drug catabolic process (GO:0042737)2.52790018
75regulation of action potential (GO:0098900)2.52065783
76microtubule-based movement (GO:0007018)2.51745575
77inner ear receptor stereocilium organization (GO:0060122)2.51450650
78reciprocal DNA recombination (GO:0035825)2.49190305
79reciprocal meiotic recombination (GO:0007131)2.49190305
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47513511
81behavioral response to ethanol (GO:0048149)2.46717199
82establishment of protein localization to Golgi (GO:0072600)2.46072886
83regulation of glucokinase activity (GO:0033131)2.42204946
84regulation of hexokinase activity (GO:1903299)2.42204946
85male meiosis (GO:0007140)2.40904946
86nucleobase catabolic process (GO:0046113)2.39304672
87benzene-containing compound metabolic process (GO:0042537)2.39060268
88reflex (GO:0060004)2.37946906
89membrane depolarization during action potential (GO:0086010)2.36953030
90centriole replication (GO:0007099)2.35207690
91organic cation transport (GO:0015695)2.34557600
92glycerophospholipid catabolic process (GO:0046475)2.32996116
93auditory receptor cell stereocilium organization (GO:0060088)2.32614775
94spermatid development (GO:0007286)2.31772808
95preassembly of GPI anchor in ER membrane (GO:0016254)2.31184723
96synaptic transmission, cholinergic (GO:0007271)2.30529567
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.30307396
98serotonin metabolic process (GO:0042428)2.30240363
99dopamine transport (GO:0015872)2.29805028
100cell differentiation in spinal cord (GO:0021515)2.29449748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.19009695
2EZH2_22144423_ChIP-Seq_EOC_Human3.18828124
3ZNF274_21170338_ChIP-Seq_K562_Hela3.11163217
4VDR_22108803_ChIP-Seq_LS180_Human2.99934479
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55664364
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54951997
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50185874
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47749009
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45213377
10IGF1R_20145208_ChIP-Seq_DFB_Human2.45067665
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38410252
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17176957
13FUS_26573619_Chip-Seq_HEK293_Human2.16425614
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07055906
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.05633587
16TAF15_26573619_Chip-Seq_HEK293_Human2.05266706
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02707953
18* P300_19829295_ChIP-Seq_ESCs_Human2.02399915
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97805841
20EWS_26573619_Chip-Seq_HEK293_Human1.90338309
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84663967
22ER_23166858_ChIP-Seq_MCF-7_Human1.84241303
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.83283110
24SMAD4_21799915_ChIP-Seq_A2780_Human1.80290674
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74397577
26* STAT3_23295773_ChIP-Seq_U87_Human1.74192294
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69620806
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67369964
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66025718
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.65539953
31BCAT_22108803_ChIP-Seq_LS180_Human1.62563310
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60745901
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59414670
34* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58245458
35CBP_20019798_ChIP-Seq_JUKART_Human1.57182993
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57182993
37TCF4_23295773_ChIP-Seq_U87_Human1.56847932
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56443847
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56423446
40AR_21572438_ChIP-Seq_LNCaP_Human1.54156357
41AR_25329375_ChIP-Seq_VCAP_Human1.53096625
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.51093010
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50584945
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47823705
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44626199
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44626199
47REST_21632747_ChIP-Seq_MESCs_Mouse1.43258533
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.41640022
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40137082
50RUNX2_22187159_ChIP-Seq_PCA_Human1.38333595
51TCF4_22108803_ChIP-Seq_LS180_Human1.38062848
52* TP53_22573176_ChIP-Seq_HFKS_Human1.31658492
53RNF2_27304074_Chip-Seq_NSC_Mouse1.31294632
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28926266
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28476391
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.27815275
57NANOG_19829295_ChIP-Seq_ESCs_Human1.27152081
58SOX2_19829295_ChIP-Seq_ESCs_Human1.27152081
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24435724
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23895171
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22894147
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22803659
63IRF1_19129219_ChIP-ChIP_H3396_Human1.21890714
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.20450523
65DROSHA_22980978_ChIP-Seq_HELA_Human1.19819800
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.18847592
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18454023
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18024061
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.17551589
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17551589
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16857257
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.16263178
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.15533059
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15171567
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14645298
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13833858
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13309720
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.11256911
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10896341
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.07266196
81AR_20517297_ChIP-Seq_VCAP_Human1.06546501
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.05436327
83NCOR_22424771_ChIP-Seq_293T_Human1.05204216
84P53_22387025_ChIP-Seq_ESCs_Mouse1.03788294
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.03687323
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01238813
87CDX2_22108803_ChIP-Seq_LS180_Human1.01223743
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01134885
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00814030
90AHR_22903824_ChIP-Seq_MCF-7_Human1.00359747
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.99239382
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.99197999
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99022924
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98493062
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97766487
96TBL1_22424771_ChIP-Seq_293T_Human0.96987598
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.96859266
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.96445735
99JUN_21703547_ChIP-Seq_K562_Human0.95923784
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94976704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.75104213
2MP0008877_abnormal_DNA_methylation2.63940382
3MP0005551_abnormal_eye_electrophysiolog2.60998498
4MP0003195_calcinosis2.58943422
5MP0009046_muscle_twitch2.28856310
6MP0000569_abnormal_digit_pigmentation2.14556224
7MP0003787_abnormal_imprinting2.05986852
8MP0005253_abnormal_eye_physiology2.01235160
9MP0003136_yellow_coat_color2.00063161
10MP0001984_abnormal_olfaction1.99993614
11MP0002638_abnormal_pupillary_reflex1.99642420
12MP0002102_abnormal_ear_morphology1.98965001
13MP0001968_abnormal_touch/_nociception1.97644268
14MP0005645_abnormal_hypothalamus_physiol1.97034516
15MP0004043_abnormal_pH_regulation1.93959516
16MP0004133_heterotaxia1.93469767
17MP0005646_abnormal_pituitary_gland1.91356477
18MP0001485_abnormal_pinna_reflex1.90116121
19MP0006292_abnormal_olfactory_placode1.88712271
20MP0008875_abnormal_xenobiotic_pharmacok1.84437727
21MP0009745_abnormal_behavioral_response1.77347759
22MP0000427_abnormal_hair_cycle1.72431326
23MP0000383_abnormal_hair_follicle1.71657463
24MP0006072_abnormal_retinal_apoptosis1.71512365
25MP0004885_abnormal_endolymph1.69443943
26MP0004142_abnormal_muscle_tone1.69337455
27MP0002837_dystrophic_cardiac_calcinosis1.68427583
28MP0002272_abnormal_nervous_system1.67941033
29MP0001486_abnormal_startle_reflex1.64465881
30MP0002160_abnormal_reproductive_system1.63524722
31MP0003878_abnormal_ear_physiology1.61520574
32MP0005377_hearing/vestibular/ear_phenot1.61520574
33MP0002736_abnormal_nociception_after1.60001627
34MP0003646_muscle_fatigue1.59697139
35MP0006276_abnormal_autonomic_nervous1.59219373
36MP0002876_abnormal_thyroid_physiology1.56859262
37MP0003880_abnormal_central_pattern1.56736894
38MP0002928_abnormal_bile_duct1.55259045
39MP0000631_abnormal_neuroendocrine_gland1.52834078
40MP0002938_white_spotting1.46019944
41MP0001986_abnormal_taste_sensitivity1.43433973
42MP0008789_abnormal_olfactory_epithelium1.41418532
43MP0001501_abnormal_sleep_pattern1.41393425
44MP0002572_abnormal_emotion/affect_behav1.40166890
45MP0005410_abnormal_fertilization1.38245659
46MP0008872_abnormal_physiological_respon1.36941130
47MP0002557_abnormal_social/conspecific_i1.36750986
48MP0005389_reproductive_system_phenotype1.32082455
49MP0002064_seizures1.26423042
50MP0005195_abnormal_posterior_eye1.22173849
51MP0001970_abnormal_pain_threshold1.22060829
52MP0000372_irregular_coat_pigmentation1.21975103
53MP0003011_delayed_dark_adaptation1.20455617
54MP0002909_abnormal_adrenal_gland1.19303825
55MP0002734_abnormal_mechanical_nocicepti1.18154893
56MP0001529_abnormal_vocalization1.17846455
57MP0004742_abnormal_vestibular_system1.17230243
58MP0003698_abnormal_male_reproductive1.16662054
59MP0004147_increased_porphyrin_level1.15134715
60MP0002822_catalepsy1.12424975
61MP0002735_abnormal_chemical_nociception1.12055541
62MP0000026_abnormal_inner_ear1.11089175
63MP0003635_abnormal_synaptic_transmissio1.11023200
64MP0000778_abnormal_nervous_system1.10858543
65MP0002063_abnormal_learning/memory/cond1.09828452
66MP0002067_abnormal_sensory_capabilities1.09216980
67MP0002733_abnormal_thermal_nociception1.09010291
68MP0003122_maternal_imprinting1.08152028
69MP0005084_abnormal_gallbladder_morpholo1.08035154
70MP0002163_abnormal_gland_morphology1.05476044
71MP0002282_abnormal_trachea_morphology1.04922575
72MP0001963_abnormal_hearing_physiology1.03665471
73MP0005379_endocrine/exocrine_gland_phen1.03540449
74MP0002229_neurodegeneration1.01468583
75MP0001929_abnormal_gametogenesis1.01425781
76MP0005394_taste/olfaction_phenotype1.00795032
77MP0005499_abnormal_olfactory_system1.00795032
78MP0003890_abnormal_embryonic-extraembry1.00520677
79MP0010386_abnormal_urinary_bladder0.98050308
80MP0002752_abnormal_somatic_nervous0.96471895
81MP0005085_abnormal_gallbladder_physiolo0.96408663
82MP0001324_abnormal_eye_pigmentation0.96198294
83MP0004924_abnormal_behavior0.95910233
84MP0005386_behavior/neurological_phenoty0.95910233
85MP0010678_abnormal_skin_adnexa0.95052374
86MP0004145_abnormal_muscle_electrophysio0.93391131
87MP0005391_vision/eye_phenotype0.92788755
88MP0008995_early_reproductive_senescence0.91942067
89MP0003879_abnormal_hair_cell0.90992616
90MP0002184_abnormal_innervation0.90704352
91MP0002234_abnormal_pharynx_morphology0.89987947
92MP0002210_abnormal_sex_determination0.88615737
93MP0003121_genomic_imprinting0.88012270
94MP0003252_abnormal_bile_duct0.87770841
95MP0005423_abnormal_somatic_nervous0.87669721
96MP0001293_anophthalmia0.87295094
97MP0001944_abnormal_pancreas_morphology0.86320915
98MP0000647_abnormal_sebaceous_gland0.86230501
99MP0001919_abnormal_reproductive_system0.83687733
100MP0005174_abnormal_tail_pigmentation0.82913978

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.69202912
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.69202912
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.41181868
4Abnormal ciliary motility (HP:0012262)6.11042380
5Abnormal respiratory motile cilium physiology (HP:0012261)5.78104852
6Abnormal respiratory motile cilium morphology (HP:0005938)5.73979421
7Abnormal respiratory epithelium morphology (HP:0012253)5.73979421
8Pancreatic fibrosis (HP:0100732)4.93148115
9Pancreatic cysts (HP:0001737)4.85138834
10True hermaphroditism (HP:0010459)4.81968617
11Rhinitis (HP:0012384)4.67654180
12Chronic hepatic failure (HP:0100626)4.60195916
13Abnormality of midbrain morphology (HP:0002418)4.45871835
14Molar tooth sign on MRI (HP:0002419)4.45871835
15Nephronophthisis (HP:0000090)4.43628963
16Abnormality of the renal medulla (HP:0100957)3.80330972
17Cystic liver disease (HP:0006706)3.55051012
18Medial flaring of the eyebrow (HP:0010747)3.54880174
19Tubular atrophy (HP:0000092)3.52218075
20Chronic bronchitis (HP:0004469)3.47005157
21Abnormality of the renal cortex (HP:0011035)3.40989331
22Bronchiectasis (HP:0002110)3.36125552
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21497398
24Occipital encephalocele (HP:0002085)3.16362126
25Gait imbalance (HP:0002141)3.04140425
26Abnormal rod and cone electroretinograms (HP:0008323)3.00315979
27Congenital primary aphakia (HP:0007707)2.97944918
28Abnormal drinking behavior (HP:0030082)2.94804347
29Polydipsia (HP:0001959)2.94804347
30Congenital stationary night blindness (HP:0007642)2.89885233
31Type II lissencephaly (HP:0007260)2.80498602
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.76574695
33Nephrogenic diabetes insipidus (HP:0009806)2.76116239
34Sclerocornea (HP:0000647)2.70489436
35Congenital hepatic fibrosis (HP:0002612)2.70345529
36Postaxial foot polydactyly (HP:0001830)2.67344845
37Bony spicule pigmentary retinopathy (HP:0007737)2.61135039
38Hyperventilation (HP:0002883)2.60211273
39Anencephaly (HP:0002323)2.52684199
40Male pseudohermaphroditism (HP:0000037)2.44262620
41Genital tract atresia (HP:0001827)2.43665465
42Bile duct proliferation (HP:0001408)2.42787779
43Abnormal biliary tract physiology (HP:0012439)2.42787779
44Attenuation of retinal blood vessels (HP:0007843)2.42215403
45Tubulointerstitial nephritis (HP:0001970)2.39714210
46Furrowed tongue (HP:0000221)2.39001761
47Vaginal atresia (HP:0000148)2.36968686
48Abolished electroretinogram (ERG) (HP:0000550)2.32843477
49Progressive cerebellar ataxia (HP:0002073)2.30696670
50Poor coordination (HP:0002370)2.25595464
51Polyuria (HP:0000103)2.19693838
52Decreased central vision (HP:0007663)2.18329126
53Nasal polyposis (HP:0100582)2.17980710
54Decreased circulating renin level (HP:0003351)2.15163197
55Postaxial hand polydactyly (HP:0001162)2.14882703
56Recurrent sinusitis (HP:0011108)2.13325211
57Genetic anticipation (HP:0003743)2.09002391
58Tubulointerstitial abnormality (HP:0001969)2.07390896
59Keratoconus (HP:0000563)1.99610362
60Increased corneal curvature (HP:0100692)1.99610362
61Gaze-evoked nystagmus (HP:0000640)1.97813526
62Chronic sinusitis (HP:0011109)1.97530446
63Large for gestational age (HP:0001520)1.94998949
64Bronchitis (HP:0012387)1.91796404
65Preaxial hand polydactyly (HP:0001177)1.90634561
66Lissencephaly (HP:0001339)1.89345822
67Pendular nystagmus (HP:0012043)1.88997000
68Supernumerary spleens (HP:0009799)1.88272473
69Constricted visual fields (HP:0001133)1.86902574
70Retinitis pigmentosa (HP:0000510)1.86649233
71Renal cortical cysts (HP:0000803)1.84432621
72Cerebellar dysplasia (HP:0007033)1.81609504
73Oculomotor apraxia (HP:0000657)1.81176169
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.78526217
75Abnormal urine output (HP:0012590)1.76139191
76Tubulointerstitial fibrosis (HP:0005576)1.73714136
77Narrow forehead (HP:0000341)1.73408334
78Protruding tongue (HP:0010808)1.73301805
79Inability to walk (HP:0002540)1.73142643
80Stage 5 chronic kidney disease (HP:0003774)1.71370585
81Anophthalmia (HP:0000528)1.70455307
82Broad-based gait (HP:0002136)1.70065398
83Infertility (HP:0000789)1.69365554
84Febrile seizures (HP:0002373)1.67294938
85Abnormality of renal excretion (HP:0011036)1.66918645
86Absent speech (HP:0001344)1.66267873
87Abnormality of macular pigmentation (HP:0008002)1.65008620
88Aganglionic megacolon (HP:0002251)1.64031587
89Focal motor seizures (HP:0011153)1.62663900
90Hemiparesis (HP:0001269)1.61850564
91Optic nerve hypoplasia (HP:0000609)1.60442287
92Aplasia/Hypoplasia of the lens (HP:0008063)1.59461194
93Dandy-Walker malformation (HP:0001305)1.59327950
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.58574549
95Hypoplasia of the fovea (HP:0007750)1.58574549
96Prominent nasal bridge (HP:0000426)1.58380484
97Oligodactyly (hands) (HP:0001180)1.57776226
98Abnormality of alanine metabolism (HP:0010916)1.57373597
99Hyperalaninemia (HP:0003348)1.57373597
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57373597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.32769942
2MAPK153.09785752
3ADRBK22.88379052
4BMPR1B2.84252980
5MAP4K22.62253098
6PINK12.57896432
7WNK32.53876478
8CASK2.46420174
9MAP3K42.36245525
10GRK12.31298720
11ZAK2.26037032
12WNK42.22789743
13TLK12.04832934
14INSRR1.96448110
15PNCK1.96421214
16MAPK131.92357425
17ACVR1B1.85818208
18OXSR11.49982178
19PTK2B1.42490354
20NUAK11.36039814
21STK38L1.32596134
22STK391.32207259
23TAOK31.28164148
24MKNK21.24962040
25NTRK31.23857127
26MAP2K71.18277931
27PAK31.09238311
28DAPK21.08348572
29DYRK21.06154103
30BCR1.02465121
31ADRBK11.01391495
32MST41.00648891
33FGFR21.00632416
34PRKCG0.97742589
35TXK0.97670775
36PRKCE0.95762588
37PLK20.95330645
38MARK10.93490709
39TRIM280.91917861
40CAMKK20.88042144
41TNIK0.87385794
42TIE10.82863904
43STK160.81208646
44TGFBR10.78833900
45MAPKAPK30.78256241
46STK30.72825874
47PHKG10.71266575
48PHKG20.71266575
49NTRK20.71204349
50CSNK1G20.70550868
51BRSK20.69676823
52STK110.67060590
53VRK10.66799216
54CSNK1G10.66463848
55ERBB30.66276952
56PLK40.65279068
57MUSK0.62831520
58CDK190.61212265
59PKN10.60553776
60IRAK10.59820220
61SGK20.58041692
62WEE10.57639403
63PRKCQ0.57556988
64CSNK1A1L0.57010149
65EPHA30.56309187
66BCKDK0.56237545
67CAMK2A0.56230101
68PIK3CA0.56125743
69ERBB20.55222692
70RPS6KA50.54765697
71NME10.54684187
72CSNK1G30.54229550
73CAMK10.51167096
74MKNK10.49261551
75SGK2230.48989238
76SGK4940.48989238
77MAP3K70.48299196
78EPHA40.48106334
79PRKACA0.47088601
80FER0.45749673
81MAP2K60.45150510
82PRKAA20.44167107
83CAMK1G0.43972716
84MAPKAPK50.43509715
85TEC0.43008321
86CDK30.42796791
87PRKCI0.42730991
88CSNK1A10.42703276
89PRKCZ0.42601663
90TRPM70.41105818
91NLK0.40687670
92PRKAA10.37159665
93STK380.36670220
94PLK10.34941129
95PRKCA0.34738775
96MAP2K40.34210274
97DYRK30.33486547
98PRKG10.33428515
99AKT30.33394427
100GRK70.32761764

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.87253443
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79780976
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.65347098
4Butanoate metabolism_Homo sapiens_hsa006502.61875810
5Linoleic acid metabolism_Homo sapiens_hsa005912.44048904
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28329143
7Nicotine addiction_Homo sapiens_hsa050332.26904323
8Nitrogen metabolism_Homo sapiens_hsa009102.23764551
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14112268
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08635855
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01863275
12Tryptophan metabolism_Homo sapiens_hsa003801.90582919
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.90205765
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90113850
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86531393
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81489356
17ABC transporters_Homo sapiens_hsa020101.80096339
18Olfactory transduction_Homo sapiens_hsa047401.71097432
19Chemical carcinogenesis_Homo sapiens_hsa052041.69264628
20Caffeine metabolism_Homo sapiens_hsa002321.64664557
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63472575
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.60289384
23Selenocompound metabolism_Homo sapiens_hsa004501.57504933
24Retinol metabolism_Homo sapiens_hsa008301.57049955
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54054148
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51087115
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50673392
28Propanoate metabolism_Homo sapiens_hsa006401.50642515
29Oxidative phosphorylation_Homo sapiens_hsa001901.49283621
30Protein export_Homo sapiens_hsa030601.47521197
31Taste transduction_Homo sapiens_hsa047421.44490223
32beta-Alanine metabolism_Homo sapiens_hsa004101.41361001
33Ether lipid metabolism_Homo sapiens_hsa005651.40601988
34Fanconi anemia pathway_Homo sapiens_hsa034601.38462748
35Morphine addiction_Homo sapiens_hsa050321.37087369
36Huntingtons disease_Homo sapiens_hsa050161.33170735
37Peroxisome_Homo sapiens_hsa041461.32836182
38Insulin secretion_Homo sapiens_hsa049111.29455511
39Homologous recombination_Homo sapiens_hsa034401.27799952
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26577404
41Histidine metabolism_Homo sapiens_hsa003401.19826541
42GABAergic synapse_Homo sapiens_hsa047271.15568545
43Circadian entrainment_Homo sapiens_hsa047131.14908632
44Basal transcription factors_Homo sapiens_hsa030221.11111851
45Glutamatergic synapse_Homo sapiens_hsa047241.06614451
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03549852
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01412817
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01062364
49Regulation of autophagy_Homo sapiens_hsa041401.00194314
50Arachidonic acid metabolism_Homo sapiens_hsa005900.99000135
51Serotonergic synapse_Homo sapiens_hsa047260.97139667
52Salivary secretion_Homo sapiens_hsa049700.91852774
53Parkinsons disease_Homo sapiens_hsa050120.89322284
54Dorso-ventral axis formation_Homo sapiens_hsa043200.86387998
55Cardiac muscle contraction_Homo sapiens_hsa042600.86007585
56Ovarian steroidogenesis_Homo sapiens_hsa049130.82570606
57Collecting duct acid secretion_Homo sapiens_hsa049660.82019763
58One carbon pool by folate_Homo sapiens_hsa006700.81092951
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79339257
60Hedgehog signaling pathway_Homo sapiens_hsa043400.78907543
61Glycerolipid metabolism_Homo sapiens_hsa005610.77524620
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74082377
63Calcium signaling pathway_Homo sapiens_hsa040200.73066007
64RNA polymerase_Homo sapiens_hsa030200.70928638
65Sphingolipid metabolism_Homo sapiens_hsa006000.69022430
66Fatty acid degradation_Homo sapiens_hsa000710.65966829
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.63982626
68Dopaminergic synapse_Homo sapiens_hsa047280.63813245
69Metabolic pathways_Homo sapiens_hsa011000.59162624
70RNA degradation_Homo sapiens_hsa030180.58495129
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57780888
72Alzheimers disease_Homo sapiens_hsa050100.56563218
73Circadian rhythm_Homo sapiens_hsa047100.56370325
74Steroid biosynthesis_Homo sapiens_hsa001000.55473705
75Tyrosine metabolism_Homo sapiens_hsa003500.54627163
76Cocaine addiction_Homo sapiens_hsa050300.53220575
77cAMP signaling pathway_Homo sapiens_hsa040240.51938941
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51825494
79Fatty acid biosynthesis_Homo sapiens_hsa000610.50371403
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47140810
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47140478
82Purine metabolism_Homo sapiens_hsa002300.47117297
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45590067
84Mineral absorption_Homo sapiens_hsa049780.45220935
85Basal cell carcinoma_Homo sapiens_hsa052170.44841320
86Amphetamine addiction_Homo sapiens_hsa050310.44622490
87Gastric acid secretion_Homo sapiens_hsa049710.42733141
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41398776
89Vitamin digestion and absorption_Homo sapiens_hsa049770.39684638
90Fat digestion and absorption_Homo sapiens_hsa049750.38328890
91Type I diabetes mellitus_Homo sapiens_hsa049400.38134495
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.37317674
93Fatty acid metabolism_Homo sapiens_hsa012120.36968030
94Phenylalanine metabolism_Homo sapiens_hsa003600.34813384
95Asthma_Homo sapiens_hsa053100.34660906
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34096705
97Sulfur metabolism_Homo sapiens_hsa009200.33910896
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.33892315
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33439066
100Oxytocin signaling pathway_Homo sapiens_hsa049210.33161602

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