DCDC2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.26096311
2multicellular organism reproduction (GO:0032504)8.36725290
3regulation of transcription from RNA polymerase I promoter (GO:0006356)8.28402811
4centriole replication (GO:0007099)8.22080291
5acrosome reaction (GO:0007340)8.07493328
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.78313706
7spermatid development (GO:0007286)7.41812986
8fusion of sperm to egg plasma membrane (GO:0007342)7.32870576
9mitotic metaphase plate congression (GO:0007080)7.30840727
10lens morphogenesis in camera-type eye (GO:0002089)7.25787139
11regulation of establishment of cell polarity (GO:2000114)6.99563265
12piRNA metabolic process (GO:0034587)6.75633713
13protein polyglutamylation (GO:0018095)6.73796755
14centriole assembly (GO:0098534)6.65057043
15sperm-egg recognition (GO:0035036)6.50917678
16reproduction (GO:0000003)6.43975201
17regulation of female gonad development (GO:2000194)6.32309099
18protein targeting to Golgi (GO:0000042)6.24123967
19sperm capacitation (GO:0048240)6.20515694
20chromosome condensation (GO:0030261)6.10140770
21regulation of retinoic acid receptor signaling pathway (GO:0048385)5.96091344
22retrograde transport, vesicle recycling within Golgi (GO:0000301)5.95449121
23establishment of protein localization to Golgi (GO:0072600)5.92948694
24binding of sperm to zona pellucida (GO:0007339)5.89767835
25DNA packaging (GO:0006323)5.74538570
26monoubiquitinated protein deubiquitination (GO:0035520)5.74520046
27DNA methylation involved in gamete generation (GO:0043046)5.74418470
28negative regulation of keratinocyte proliferation (GO:0010839)5.70934640
29regulation of establishment or maintenance of cell polarity (GO:0032878)5.68877089
30cell wall macromolecule catabolic process (GO:0016998)5.63931412
31metaphase plate congression (GO:0051310)5.56356215
32microtubule severing (GO:0051013)5.56014446
33spermatogenesis (GO:0007283)5.55734376
34male gamete generation (GO:0048232)5.54017022
35single fertilization (GO:0007338)5.50603001
36plasma membrane fusion (GO:0045026)5.43534669
37cell-cell recognition (GO:0009988)5.42463522
38meiotic cell cycle (GO:0051321)5.40674801
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.40261495
40DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.38781080
41microtubule depolymerization (GO:0007019)5.34859267
42fertilization (GO:0009566)5.30650740
43cell wall macromolecule metabolic process (GO:0044036)5.25790387
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.25355228
45gamete generation (GO:0007276)5.24535959
46regulation of exit from mitosis (GO:0007096)5.22475504
47DNA damage response, signal transduction resulting in transcription (GO:0042772)5.19594485
48regulation of spindle organization (GO:0090224)5.18754690
49regulation of meiosis I (GO:0060631)5.18046445
50calcium ion-dependent exocytosis (GO:0017156)5.17506128
51seminiferous tubule development (GO:0072520)5.11408748
52regulation of centriole replication (GO:0046599)5.11330301
53snRNA transcription (GO:0009301)5.10949870
54rRNA methylation (GO:0031167)5.09600508
55axonemal dynein complex assembly (GO:0070286)5.00622335
56meiotic chromosome segregation (GO:0045132)4.97898525
57spermatid nucleus differentiation (GO:0007289)4.89765240
58meiosis I (GO:0007127)4.89437577
59regulation of RNA export from nucleus (GO:0046831)4.86388078
60cilium or flagellum-dependent cell motility (GO:0001539)4.83903387
61negative regulation of DNA-dependent DNA replication (GO:2000104)4.82365184
62regulation of acrosome reaction (GO:0060046)4.81909864
63germ cell development (GO:0007281)4.75516915
64male meiosis I (GO:0007141)4.70548035
65regulation of DNA methylation (GO:0044030)4.58311533
66protein K6-linked ubiquitination (GO:0085020)4.53074888
67oocyte maturation (GO:0001556)4.52080454
68protein localization to Golgi apparatus (GO:0034067)4.50584874
69phosphatidylethanolamine biosynthetic process (GO:0006646)4.48566321
70epithelial cilium movement (GO:0003351)4.46521771
71establishment of chromosome localization (GO:0051303)4.46263213
72single strand break repair (GO:0000012)4.45855320
73mitotic chromosome condensation (GO:0007076)4.43476931
74protein localization to chromosome, centromeric region (GO:0071459)4.41479828
75inner cell mass cell proliferation (GO:0001833)4.39843997
76regulation of histone H3-K9 methylation (GO:0051570)4.39687883
77protein localization to kinetochore (GO:0034501)4.37139881
78DNA replication checkpoint (GO:0000076)4.37114176
79female gonad development (GO:0008585)4.36893674
80retinal cone cell development (GO:0046549)4.36145364
81cellular process involved in reproduction in multicellular organism (GO:0022412)4.35541012
82regulation of sister chromatid cohesion (GO:0007063)4.31422003
83regulation of cilium movement (GO:0003352)4.27447742
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.25439826
85positive regulation of chromosome segregation (GO:0051984)4.25338722
86rRNA modification (GO:0000154)4.25057450
87motile cilium assembly (GO:0044458)4.19466361
88negative regulation of hormone metabolic process (GO:0032351)4.19398575
89negative regulation of hormone biosynthetic process (GO:0032353)4.19398575
90negative regulation of histone methylation (GO:0031061)4.18281357
91pentose metabolic process (GO:0019321)4.17254712
92multicellular organismal reproductive process (GO:0048609)4.15126080
93phosphatidylethanolamine metabolic process (GO:0046337)4.13832052
94glucose catabolic process (GO:0006007)4.11983749
95pentose-phosphate shunt (GO:0006098)4.09372599
96sister chromatid cohesion (GO:0007062)4.06230058
97histone H2A monoubiquitination (GO:0035518)4.02258808
98synapsis (GO:0007129)4.01356452
99regulation of telomere maintenance via telomerase (GO:0032210)4.00845429
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.98416240
101protein localization to chromosome (GO:0034502)3.98189373
102resolution of meiotic recombination intermediates (GO:0000712)3.95565903
103regulation of nucleobase-containing compound transport (GO:0032239)3.93320720
104regulation of mitotic spindle organization (GO:0060236)3.92700727
105regulation of germinal center formation (GO:0002634)3.92126412
106cellular response to pH (GO:0071467)3.91224177
107response to acidic pH (GO:0010447)3.90879876
108cilium movement (GO:0003341)3.89199794
109nuclear pore complex assembly (GO:0051292)3.88136316
110RNA destabilization (GO:0050779)3.87462638
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.87299805
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.87299805
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.87299805
114negative regulation of telomere maintenance (GO:0032205)3.86992113
115regulation of keratinocyte proliferation (GO:0010837)3.86596075
116microtubule polymerization or depolymerization (GO:0031109)3.86567041
117chromosome organization involved in meiosis (GO:0070192)3.84601364
118sphingosine metabolic process (GO:0006670)3.83034502
119glomerular visceral epithelial cell development (GO:0072015)3.81447740
120histone H3-K9 demethylation (GO:0033169)3.78136498
121mitotic sister chromatid cohesion (GO:0007064)3.73507136
122synaptonemal complex assembly (GO:0007130)3.70777822
123regulation of double-strand break repair via homologous recombination (GO:0010569)3.66384646
124multicellular organismal movement (GO:0050879)3.60814163
125musculoskeletal movement (GO:0050881)3.60814163
126histone exchange (GO:0043486)3.59583251
127poly(A)+ mRNA export from nucleus (GO:0016973)3.59084457
128NADPH regeneration (GO:0006740)3.57783382
129positive regulation of Rab GTPase activity (GO:0032851)3.57568913
130regulation of Rab GTPase activity (GO:0032313)3.57568913
131diol metabolic process (GO:0034311)3.56176344
132histone demethylation (GO:0016577)3.55248391
133centrosome duplication (GO:0051298)3.52862654
134histone lysine demethylation (GO:0070076)3.50283312
135oocyte development (GO:0048599)3.49870427
136negative regulation of cell aging (GO:0090344)3.49708981
137negative regulation of meiosis (GO:0045835)3.49051547
138oogenesis (GO:0048477)3.48149548
139response to UV-C (GO:0010225)3.46601937
140glomerular epithelial cell development (GO:0072310)3.46293596
141meiotic cell cycle process (GO:1903046)3.42456093
142nuclear pore organization (GO:0006999)3.42265981
143regulation of meiosis (GO:0040020)3.41298041
144regulation of chromosome segregation (GO:0051983)3.38285350
145synaptonemal complex organization (GO:0070193)3.37851896
146glycine transport (GO:0015816)3.36892014
147male meiosis (GO:0007140)3.35607323
148meiotic nuclear division (GO:0007126)3.34530668
149regulation of phosphoprotein phosphatase activity (GO:0043666)3.30569817
150organic cation transport (GO:0015695)3.30197146
151negative regulation of inclusion body assembly (GO:0090084)3.29895819
152microtubule nucleation (GO:0007020)3.29465034
153histone H2A ubiquitination (GO:0033522)3.28609270
154DNA damage induced protein phosphorylation (GO:0006975)3.28259835
155purine nucleobase biosynthetic process (GO:0009113)3.27662096
156relaxation of smooth muscle (GO:0044557)3.26892247
157regulation of steroid hormone secretion (GO:2000831)3.26744797
158protein dealkylation (GO:0008214)3.25989039
159protein demethylation (GO:0006482)3.25989039
160negative regulation of DNA replication (GO:0008156)3.25123807
161kinetochore assembly (GO:0051382)3.24671373
162mitotic sister chromatid segregation (GO:0000070)3.24653681
163chromosome segregation (GO:0007059)3.22364452
164gene silencing by RNA (GO:0031047)3.19693862
165vitamin transmembrane transport (GO:0035461)3.10836535
166polyamine biosynthetic process (GO:0006596)3.10497744
167DNA synthesis involved in DNA repair (GO:0000731)3.09830427
168CENP-A containing nucleosome assembly (GO:0034080)3.09174353
169regulation of microtubule-based movement (GO:0060632)3.07178129
170positive regulation of histone H3-K4 methylation (GO:0051571)3.06212327
171transcription elongation from RNA polymerase II promoter (GO:0006368)3.05756988
172vesicle transport along microtubule (GO:0047496)3.05280879
173protein monoubiquitination (GO:0006513)3.02778094
174replication fork processing (GO:0031297)3.02547637
175reciprocal meiotic recombination (GO:0007131)3.00670596
176reciprocal DNA recombination (GO:0035825)3.00670596
177chromatin remodeling at centromere (GO:0031055)2.96797671
178sphingoid metabolic process (GO:0046519)2.96563739
179nucleus organization (GO:0006997)2.95253872
180spindle checkpoint (GO:0031577)2.94611211
181female gamete generation (GO:0007292)2.94525797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.23434920
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.47567285
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.62700033
4E2F7_22180533_ChIP-Seq_HELA_Human5.21303239
5FOXM1_23109430_ChIP-Seq_U2OS_Human5.09611557
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.14469049
7KAP1_22055183_ChIP-Seq_ESCs_Mouse4.03111498
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.65370564
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.30477407
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99134185
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.89666914
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78909084
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.72388049
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69654500
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.64588534
16IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.45746101
17CBP_20019798_ChIP-Seq_JUKART_Human2.45746101
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.44562691
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33437291
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31285670
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25512352
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24176427
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17715272
24AR_21909140_ChIP-Seq_LNCAP_Human2.05212690
25GBX2_23144817_ChIP-Seq_PC3_Human2.04251669
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99449828
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97825698
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94367177
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.93424862
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.91138472
31LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87520013
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74341043
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73644734
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72487389
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72487389
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72191871
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.70421103
38IGF1R_20145208_ChIP-Seq_DFB_Human1.68623566
39DROSHA_22980978_ChIP-Seq_HELA_Human1.65361663
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65242392
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.62626742
42NANOG_20526341_ChIP-Seq_ESCs_Human1.61305072
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61117771
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60654090
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58906257
46AR_25329375_ChIP-Seq_VCAP_Human1.56498487
47P300_19829295_ChIP-Seq_ESCs_Human1.55912986
48FUS_26573619_Chip-Seq_HEK293_Human1.55712817
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55187927
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54007629
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.53921751
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.52584770
53RUNX1_26923725_Chip-Seq_HPCs_Mouse1.51223437
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49831291
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49783491
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49740806
57STAT3_23295773_ChIP-Seq_U87_Human1.48355253
58SMAD4_21799915_ChIP-Seq_A2780_Human1.47951264
59ER_23166858_ChIP-Seq_MCF-7_Human1.47156773
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45239730
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44276072
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.41757169
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41176792
64RNF2_27304074_Chip-Seq_NSC_Mouse1.41014315
65AR_21572438_ChIP-Seq_LNCaP_Human1.40849349
66RUNX2_22187159_ChIP-Seq_PCA_Human1.40517706
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39704674
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.37557095
69TCF4_23295773_ChIP-Seq_U87_Human1.36620828
70MYC_19829295_ChIP-Seq_ESCs_Human1.34892894
71ZNF274_21170338_ChIP-Seq_K562_Hela1.32922769
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.31054265
73RAC3_21632823_ChIP-Seq_H3396_Human1.30119771
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28013109
75ERG_20517297_ChIP-Seq_VCAP_Human1.26952887
76NANOG_19829295_ChIP-Seq_ESCs_Human1.21638918
77SOX2_19829295_ChIP-Seq_ESCs_Human1.21638918
78TBL1_22424771_ChIP-Seq_293T_Human1.20377980
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19801419
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19686156
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17818498
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.17112316
83TP53_18474530_ChIP-ChIP_U2OS_Human1.16957341
84AHR_22903824_ChIP-Seq_MCF-7_Human1.16542590
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16388037
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.16153361
87ERA_21632823_ChIP-Seq_H3396_Human1.15313374
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15202852
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14343826
90TAF2_19829295_ChIP-Seq_ESCs_Human1.13817387
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12328626
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11583273
93OCT4_20526341_ChIP-Seq_ESCs_Human1.11052521
94IRF1_19129219_ChIP-ChIP_H3396_Human1.09963888
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.09617947
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08417381
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.08058310
98STAT3_18555785_ChIP-Seq_MESCs_Mouse1.07977637
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06741218
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.05790515
101CDX2_22108803_ChIP-Seq_LS180_Human1.05495289
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05251118
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05178668
104CBP_21632823_ChIP-Seq_H3396_Human1.04820659
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04384555
106OCT1_27270436_Chip-Seq_PROSTATE_Human1.03668536
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.03630071
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02656593
109SALL4_22934838_ChIP-ChIP_CD34+_Human1.02212806
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.01938060
111SMRT_27268052_Chip-Seq_Bcells_Human1.01489294
112CEBPB_22108803_ChIP-Seq_LS180_Human1.00771128
113MYC_18940864_ChIP-ChIP_HL60_Human1.00575418
114FOXH1_21741376_ChIP-Seq_EPCs_Human1.00269968
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.99693161
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.99528151
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97053640
118ETV1_20927104_ChIP-Seq_GIST48_Human0.97050598
119TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.96924902
120P53_22387025_ChIP-Seq_ESCs_Mouse0.96360370
121NFYA_21822215_ChIP-Seq_K562_Human0.96223669
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95379587
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94795222
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94386757
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94271822
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93838698
127NMYC_18555785_Chip-Seq_ESCs_Mouse0.93198000
128KDM2B_26808549_Chip-Seq_REH_Human0.92990808
129GATA3_26560356_Chip-Seq_TH1_Human0.92526674
130CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91812707
131ZFX_18555785_Chip-Seq_ESCs_Mouse0.91076479
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.90647642
133STAT1_17558387_ChIP-Seq_HELA_Human0.89712984
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89266543
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.88382093
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.88278419
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88127022
138KAP1_27257070_Chip-Seq_ESCs_Mouse0.87687127
139TCF4_22108803_ChIP-Seq_LS180_Human0.87588287
140KLF4_19829295_ChIP-Seq_ESCs_Human0.87428852
141HOXB7_26014856_ChIP-Seq_BT474_Human0.86880261
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86431309
143KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86394482
144E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86385840
145P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86327126
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.86117755
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86108574
148EOMES_21245162_ChIP-Seq_HESCs_Human0.84525991
149RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84314739
150EWS_26573619_Chip-Seq_HEK293_Human0.83340090
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.83163470
152PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81132299
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80780908
154PHF8_20622853_ChIP-Seq_HELA_Human0.80076310
155CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80054846
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79888424
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78419461
158GATA6_21074721_ChIP-Seq_CACO-2_Human0.77314859
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77056092
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.76733857
161NFYB_21822215_ChIP-Seq_K562_Human0.76659761
162TAF15_26573619_Chip-Seq_HEK293_Human0.76278320
163VDR_22108803_ChIP-Seq_LS180_Human0.74737185
164GF1_26923725_Chip-Seq_HPCs_Mouse0.73673740
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.73045544
166RBPJ_21746931_ChIP-Seq_IB4_Human0.72540987
167CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.72340888
168TCF3_18692474_ChIP-Seq_MESCs_Mouse0.71838533
169GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71568558
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.70934259
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70868777
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.70794150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.13211337
2MP0006292_abnormal_olfactory_placode5.49362280
3MP0008057_abnormal_DNA_replication3.95765206
4MP0008007_abnormal_cellular_replicative3.95133022
5MP0000566_synostosis3.93421205
6MP0003693_abnormal_embryo_hatching3.67732399
7MP0005377_hearing/vestibular/ear_phenot3.56717879
8MP0003878_abnormal_ear_physiology3.56717879
9MP0005451_abnormal_body_composition3.39620646
10MP0003111_abnormal_nucleus_morphology3.27584804
11MP0008877_abnormal_DNA_methylation3.24371949
12MP0005670_abnormal_white_adipose3.23150268
13MP0002102_abnormal_ear_morphology3.12123666
14MP0003077_abnormal_cell_cycle3.04713074
15MP0005408_hypopigmentation2.76880240
16MP0010094_abnormal_chromosome_stability2.63557895
17MP0003718_maternal_effect2.61032284
18MP0008058_abnormal_DNA_repair2.52822485
19MP0003879_abnormal_hair_cell2.45877530
20MP0002653_abnormal_ependyma_morphology2.40350160
21MP0001984_abnormal_olfaction2.33401727
22MP0010307_abnormal_tumor_latency2.26421802
23MP0005360_urolithiasis2.17689026
24MP0002138_abnormal_hepatobiliary_system2.15860030
25MP0003937_abnormal_limbs/digits/tail_de2.14506631
26MP0004957_abnormal_blastocyst_morpholog2.08631767
27MP0002234_abnormal_pharynx_morphology2.05361672
28MP0001529_abnormal_vocalization1.98927536
29MP0001730_embryonic_growth_arrest1.85869309
30MP0003787_abnormal_imprinting1.83960453
31MP0005647_abnormal_sex_gland1.77595237
32MP0001929_abnormal_gametogenesis1.75017384
33MP0002396_abnormal_hematopoietic_system1.74335932
34MP0002210_abnormal_sex_determination1.70857962
35MP0000350_abnormal_cell_proliferation1.66309822
36MP0004185_abnormal_adipocyte_glucose1.65671240
37MP0005551_abnormal_eye_electrophysiolog1.63655539
38MP0008004_abnormal_stomach_pH1.62297606
39MP0003136_yellow_coat_color1.55898629
40MP0002139_abnormal_hepatobiliary_system1.55107591
41MP0003938_abnormal_ear_development1.50431877
42MP0000653_abnormal_sex_gland1.49937877
43MP0001672_abnormal_embryogenesis/_devel1.46990317
44MP0005380_embryogenesis_phenotype1.46990317
45MP0005197_abnormal_uvea_morphology1.44811324
46MP0002277_abnormal_respiratory_mucosa1.40684576
47MP0001145_abnormal_male_reproductive1.39914423
48MP0002085_abnormal_embryonic_tissue1.39232001
49MP0001119_abnormal_female_reproductive1.39216457
50MP0000579_abnormal_nail_morphology1.37841363
51MP0001485_abnormal_pinna_reflex1.37447889
52MP0002084_abnormal_developmental_patter1.36299808
53MP0003646_muscle_fatigue1.33472460
54MP0009333_abnormal_splenocyte_physiolog1.32227105
55MP0001486_abnormal_startle_reflex1.29277996
56MP0003699_abnormal_female_reproductive1.28813221
57MP0008789_abnormal_olfactory_epithelium1.28607363
58MP0003123_paternal_imprinting1.28285239
59MP0005395_other_phenotype1.27036583
60MP0003755_abnormal_palate_morphology1.23267345
61MP0008995_early_reproductive_senescence1.21592879
62MP0010368_abnormal_lymphatic_system1.21203396
63MP0002163_abnormal_gland_morphology1.21036222
64MP0005248_abnormal_Harderian_gland1.19896828
65MP0003984_embryonic_growth_retardation1.19339501
66MP0001963_abnormal_hearing_physiology1.18250113
67MP0001697_abnormal_embryo_size1.11750725
68MP0008932_abnormal_embryonic_tissue1.11594023
69MP0000678_abnormal_parathyroid_gland1.11440581
70MP0002088_abnormal_embryonic_growth/wei1.10247684
71MP0001188_hyperpigmentation1.09261599
72MP0009697_abnormal_copulation1.07912530
73MP0003698_abnormal_male_reproductive1.07486891
74MP0009672_abnormal_birth_weight1.06567168
75MP0002638_abnormal_pupillary_reflex1.05924312
76MP0005646_abnormal_pituitary_gland1.03560196
77MP0002127_abnormal_cardiovascular_syste1.02784286
78MP0005499_abnormal_olfactory_system1.02350793
79MP0005394_taste/olfaction_phenotype1.02350793
80MP0002233_abnormal_nose_morphology1.01565846
81MP0003183_abnormal_peptide_metabolism1.01496516
82MP0002272_abnormal_nervous_system1.01385242
83MP0005423_abnormal_somatic_nervous1.01304732
84MP0003828_pulmonary_edema1.00108030
85MP0000026_abnormal_inner_ear0.98731188
86MP0001661_extended_life_span0.98730971
87MP0002938_white_spotting0.97279343
88MP0004084_abnormal_cardiac_muscle0.95547810
89MP0000639_abnormal_adrenal_gland0.94144393
90MP0003935_abnormal_craniofacial_develop0.93672373
91MP0002229_neurodegeneration0.92320412
92MP0000462_abnormal_digestive_system0.91553177
93MP0005409_darkened_coat_color0.91298716
94MP0000627_abnormal_mammary_gland0.90634882
95MP0001851_eye_inflammation0.90303780
96MP0003315_abnormal_perineum_morphology0.89999307
97MP0002086_abnormal_extraembryonic_tissu0.89913673
98MP0006276_abnormal_autonomic_nervous0.88689407
99MP0002161_abnormal_fertility/fecundity0.86971406
100MP0002877_abnormal_melanocyte_morpholog0.86702027
101MP0004264_abnormal_extraembryonic_tissu0.86414356
102MP0010030_abnormal_orbit_morphology0.86331694
103MP0002249_abnormal_larynx_morphology0.83385009
104MP0000428_abnormal_craniofacial_morphol0.82869865
105MP0003861_abnormal_nervous_system0.81410711
106MP0005076_abnormal_cell_differentiation0.78116208
107MP0002080_prenatal_lethality0.77612711
108MP0003121_genomic_imprinting0.77332283
109MP0010234_abnormal_vibrissa_follicle0.76000337
110MP0005379_endocrine/exocrine_gland_phen0.75246538
111MP0003890_abnormal_embryonic-extraembry0.75130652
112MP0000569_abnormal_digit_pigmentation0.74095730
113MP0004085_abnormal_heartbeat0.73886554
114MP0005621_abnormal_cell_physiology0.73449487
115MP0001664_abnormal_digestion0.72778892
116MP0005389_reproductive_system_phenotype0.72475627
117MP0005187_abnormal_penis_morphology0.71747709
118MP0000631_abnormal_neuroendocrine_gland0.71664826
119MP0003880_abnormal_central_pattern0.71592917
120MP0001545_abnormal_hematopoietic_system0.71166186
121MP0005397_hematopoietic_system_phenotyp0.71166186
122MP0002067_abnormal_sensory_capabilities0.71111394
123MP0001666_abnormal_nutrient_absorption0.71036201
124MP0002735_abnormal_chemical_nociception0.70957588
125MP0001905_abnormal_dopamine_level0.70707559
126MP0002160_abnormal_reproductive_system0.70492066
127MP0004742_abnormal_vestibular_system0.69994323
128MP0001293_anophthalmia0.69582811
129MP0000647_abnormal_sebaceous_gland0.69149213
130MP0005253_abnormal_eye_physiology0.68175094
131MP0003936_abnormal_reproductive_system0.68066594
132MP0001765_abnormal_ion_homeostasis0.67854026
133MP0009250_abnormal_appendicular_skeleto0.66840692
134MP0003868_abnormal_feces_composition0.66816771
135MP0000432_abnormal_head_morphology0.66442864
136MP0009115_abnormal_fat_cell0.65857865
137MP0001348_abnormal_lacrimal_gland0.65507939
138MP0000383_abnormal_hair_follicle0.64594382
139MP0004859_abnormal_synaptic_plasticity0.64521616
140MP0003950_abnormal_plasma_membrane0.64334247
141MP0000049_abnormal_middle_ear0.64119294
142MP0002697_abnormal_eye_size0.60462358
143MP0004215_abnormal_myocardial_fiber0.60109728
144MP0005310_abnormal_salivary_gland0.59634200
145MP0002132_abnormal_respiratory_system0.58927941
146MP0003385_abnormal_body_wall0.58648637
147MP0000778_abnormal_nervous_system0.58318390
148MP0002572_abnormal_emotion/affect_behav0.57923514
149MP0003137_abnormal_impulse_conducting0.57633729
150MP0000230_abnormal_systemic_arterial0.55848667
151MP0000470_abnormal_stomach_morphology0.53300530
152MP0002269_muscular_atrophy0.51235626
153MP0003252_abnormal_bile_duct0.51117025
154MP0002557_abnormal_social/conspecific_i0.49305024
155MP0001501_abnormal_sleep_pattern0.47810174
156MP0003119_abnormal_digestive_system0.47664055
157MP0002928_abnormal_bile_duct0.47101859
158MP0002822_catalepsy0.46716767
159MP0003631_nervous_system_phenotype0.46509361
160MP0009745_abnormal_behavioral_response0.44306256
161MP0004036_abnormal_muscle_relaxation0.42657173
162MP0000762_abnormal_tongue_morphology0.42486230
163MP0003632_abnormal_nervous_system0.41498795
164MP0002734_abnormal_mechanical_nocicepti0.41493600

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)6.97108907
2Prostate neoplasm (HP:0100787)6.62331239
3Chromosomal breakage induced by crosslinking agents (HP:0003221)6.61621126
4Chromsome breakage (HP:0040012)6.02904822
5Capillary hemangiomas (HP:0005306)5.88781735
6Tubulointerstitial nephritis (HP:0001970)5.67581302
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.34555549
8Absent/shortened dynein arms (HP:0200106)5.34555549
9Papillary thyroid carcinoma (HP:0002895)5.02934736
10Chronic hepatic failure (HP:0100626)4.99809949
11Birth length less than 3rd percentile (HP:0003561)4.87729515
12Severe visual impairment (HP:0001141)4.80223365
13Infertility (HP:0000789)4.78965449
14Abnormal ciliary motility (HP:0012262)4.67906288
15Sensorimotor neuropathy (HP:0007141)4.57609480
16Abnormal respiratory motile cilium physiology (HP:0012261)4.55907497
17Abnormality of the labia minora (HP:0012880)4.46701026
18Cone-rod dystrophy (HP:0000548)4.17253607
19Microglossia (HP:0000171)4.16897901
20Asymmetric septal hypertrophy (HP:0001670)3.92478420
21Meckel diverticulum (HP:0002245)3.90053925
22Osteomalacia (HP:0002749)3.87191671
23Patellar aplasia (HP:0006443)3.84576067
24Anterior segment dysgenesis (HP:0007700)3.84471282
25Abnormality of the preputium (HP:0100587)3.75845576
26Breast hypoplasia (HP:0003187)3.73030943
27Aplasia/Hypoplasia of the uvula (HP:0010293)3.72324880
28Renovascular hypertension (HP:0100817)3.70147273
29Hypophosphatemic rickets (HP:0004912)3.68523903
30Attenuation of retinal blood vessels (HP:0007843)3.65570571
31Abnormality of the ileum (HP:0001549)3.63225004
32Abnormality of macular pigmentation (HP:0008002)3.58211677
33Azoospermia (HP:0000027)3.57206781
34Resting tremor (HP:0002322)3.52564936
35Aplasia/Hypoplasia of the patella (HP:0006498)3.52155388
36Oligodactyly (HP:0012165)3.50962981
37Acute myeloid leukemia (HP:0004808)3.44915051
38Abnormality of the prostate (HP:0008775)3.43493561
39Aplasia/Hypoplasia of the earlobes (HP:0009906)3.41178833
40Shawl scrotum (HP:0000049)3.40953489
41Abnormality of chromosome stability (HP:0003220)3.39440128
42Truncal obesity (HP:0001956)3.39350457
43Abnormal respiratory motile cilium morphology (HP:0005938)3.35074288
44Abnormal respiratory epithelium morphology (HP:0012253)3.35074288
45Abdominal situs inversus (HP:0003363)3.29775580
46Abnormality of abdominal situs (HP:0011620)3.29775580
47Oligodactyly (hands) (HP:0001180)3.25002530
48Acute lymphatic leukemia (HP:0006721)3.24868016
49Breast aplasia (HP:0100783)3.18593517
50Hyperkalemia (HP:0002153)3.14101489
51Myokymia (HP:0002411)3.13226526
52Bony spicule pigmentary retinopathy (HP:0007737)3.11869374
53Thyroid carcinoma (HP:0002890)3.08283371
54Spontaneous abortion (HP:0005268)3.07852887
55Abnormal spermatogenesis (HP:0008669)3.05140288
56Subcapsular cataract (HP:0000523)3.02791931
57Aplasia/Hypoplasia of the breasts (HP:0010311)3.00688006
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91629219
59Median cleft lip (HP:0000161)2.88512503
60Congenital sensorineural hearing impairment (HP:0008527)2.83553568
61Rhinitis (HP:0012384)2.81252124
62Adrenal hypoplasia (HP:0000835)2.78209178
63Nasal polyposis (HP:0100582)2.78006590
64Male infertility (HP:0003251)2.77512831
65Tubulointerstitial abnormality (HP:0001969)2.77271854
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.76509317
67Postural instability (HP:0002172)2.76303294
68Abnormality of male internal genitalia (HP:0000022)2.74668963
69Hypoalphalipoproteinemia (HP:0003233)2.72252463
70Clubbing of toes (HP:0100760)2.69128612
71Ectopic kidney (HP:0000086)2.68682293
72Impulsivity (HP:0100710)2.66610014
73Menstrual irregularities (HP:0000858)2.65732073
74Short thumb (HP:0009778)2.63998936
75Abnormality of the phalanges of the hallux (HP:0010057)2.62663309
76Abnormality of the hepatic vasculature (HP:0006707)2.58580742
77Abnormality of lateral ventricle (HP:0030047)2.56097992
78Progressive sensorineural hearing impairment (HP:0000408)2.55242255
79Lip pit (HP:0100267)2.53163431
80Nephroblastoma (Wilms tumor) (HP:0002667)2.52559424
81Abnormality of the carotid arteries (HP:0005344)2.51475818
82Generalized aminoaciduria (HP:0002909)2.49799684
83Duodenal stenosis (HP:0100867)2.47798082
84Small intestinal stenosis (HP:0012848)2.47798082
85Nephronophthisis (HP:0000090)2.47555410
86Myelodysplasia (HP:0002863)2.47107052
87Carpal bone hypoplasia (HP:0001498)2.47020211
88Progressive cerebellar ataxia (HP:0002073)2.43817677
89Pancreatic fibrosis (HP:0100732)2.40805838
90Type II lissencephaly (HP:0007260)2.40552740
91Flat capital femoral epiphysis (HP:0003370)2.37849282
92Optic nerve hypoplasia (HP:0000609)2.37284703
93Insulin-resistant diabetes mellitus (HP:0000831)2.37259661
94Abnormality of dental color (HP:0011073)2.35358126
95Chronic bronchitis (HP:0004469)2.34154114
96Enlarged epiphyses (HP:0010580)2.32741413
97Portal hypertension (HP:0001409)2.32697443
98Abnormality of the nasal mucosa (HP:0000433)2.31598748
99Embryonal renal neoplasm (HP:0011794)2.31168224
100Bundle branch block (HP:0011710)2.30826897
101Absent radius (HP:0003974)2.30166432
102Rib fusion (HP:0000902)2.29548967
103Short tibia (HP:0005736)2.29031774
104Abnormal gallbladder physiology (HP:0012438)2.28828377
105Cholecystitis (HP:0001082)2.28828377
106Abnormality of the fingertips (HP:0001211)2.28742529
107Cerebellar dysplasia (HP:0007033)2.26765519
108Overlapping toe (HP:0001845)2.23619319
109Bell-shaped thorax (HP:0001591)2.22485633
110Focal motor seizures (HP:0011153)2.22414204
111Arteriovenous malformation (HP:0100026)2.22357888
112Abnormality of the fovea (HP:0000493)2.21547908
113Abnormality of chromosome segregation (HP:0002916)2.21428667
114Amelogenesis imperfecta (HP:0000705)2.19321902
115Aplasia involving forearm bones (HP:0009822)2.19115518
116Absent forearm bone (HP:0003953)2.19115518
117Septo-optic dysplasia (HP:0100842)2.18693505
118Supernumerary spleens (HP:0009799)2.15165390
119Hypoplasia of the thymus (HP:0000778)2.14798288
120Abnormality of the septum pellucidum (HP:0007375)2.12758179
121Horseshoe kidney (HP:0000085)2.10559581
122Abnormality of the aortic arch (HP:0012303)2.09380468
123Tracheoesophageal fistula (HP:0002575)2.08893210
124Aplasia/Hypoplasia of the tibia (HP:0005772)2.07961725
125Abnormality of the renal medulla (HP:0100957)2.07844044
126Hypokinesia (HP:0002375)2.05993547
127Photophobia (HP:0000613)2.05293952
128Triphalangeal thumb (HP:0001199)2.04425772
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03751811
130Bone marrow hypocellularity (HP:0005528)2.03537567
131Potter facies (HP:0002009)2.03479092
132Facial shape deformation (HP:0011334)2.03479092
133Wrist flexion contracture (HP:0001239)2.02868249
134Enlarged penis (HP:0000040)2.01875223
135Intellectual disability, moderate (HP:0002342)2.00751474
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.97507467
137Growth hormone deficiency (HP:0000824)1.97389087
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96876871
139Abnormality of the duodenum (HP:0002246)1.96829481
140Abnormality of DNA repair (HP:0003254)1.96737090
141Absent septum pellucidum (HP:0001331)1.96444179
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.93961181
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92056955
144Abnormality of midbrain morphology (HP:0002418)1.89712253
145Molar tooth sign on MRI (HP:0002419)1.89712253
146Self-mutilation (HP:0000742)1.88235241
147Stage 5 chronic kidney disease (HP:0003774)1.86542412
148Anal atresia (HP:0002023)1.86507082
149Pancreatic cysts (HP:0001737)1.85927747
150Long eyelashes (HP:0000527)1.85004583
151Hypoplasia of the fovea (HP:0007750)1.83364967
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.83364967
153Hypergonadotropic hypogonadism (HP:0000815)1.81296067
154Cystic hygroma (HP:0000476)1.80447994
155Complete atrioventricular canal defect (HP:0001674)1.80346681
156Atrial fibrillation (HP:0005110)1.80253758
157Syncope (HP:0001279)1.79887453
158Increased purine levels (HP:0004368)1.78273738
159Hyperuricemia (HP:0002149)1.78273738
160Embryonal neoplasm (HP:0002898)1.78194799
161Absent eyebrow (HP:0002223)1.77883412
162Oral leukoplakia (HP:0002745)1.76786790
163Microtia (HP:0008551)1.74065312
164Abnormal lung lobation (HP:0002101)1.73798636
165Aplasia/Hypoplasia of the sternum (HP:0006714)1.72597378
166Abnormal hair whorl (HP:0010721)1.72383125
167Intellectual disability, mild (HP:0001256)1.70866325
168Breech presentation (HP:0001623)1.69914206
169Febrile seizures (HP:0002373)1.68172852
170Abnormal delivery (HP:0001787)1.66599426
171Cafe-au-lait spot (HP:0000957)1.65432333
172Short 4th metacarpal (HP:0010044)1.62896060
173Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62896060
174Myocardial infarction (HP:0001658)1.62354548
175Fair hair (HP:0002286)1.62181210
176Polycythemia (HP:0001901)1.61860014
177Bicornuate uterus (HP:0000813)1.61267922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS26.82463020
2LATS15.15222871
3STK38L4.71725888
4MAP3K93.79425470
5BRD43.72127038
6MAP3K133.48543017
7ARAF3.44704838
8INSRR3.19736370
9BRSK22.96490044
10CDC72.92561141
11SRPK12.86525293
12DYRK22.56698465
13WEE12.54086146
14STK32.42213244
15PINK12.31477546
16TESK12.25798013
17DYRK32.11708248
18MAP3K62.01191528
19BRAF1.99048905
20PNCK1.95772495
21CDK121.94694205
22DDR21.87123472
23NEK21.86401130
24PLK11.76674858
25ERBB41.74491497
26PLK41.74137738
27CDK31.71040080
28FRK1.68388131
29ACVR1B1.66517820
30MKNK21.65783223
31MOS1.58079668
32CHEK21.55963616
33ABL21.50471467
34PLK31.47641459
35BRSK11.45528178
36BUB11.43481020
37PIK3CG1.39982097
38TTK1.39326383
39PRKD31.38482189
40STK381.35411075
41MAPK151.31933656
42EPHA31.27762537
43TYRO31.25355934
44AURKB1.23864233
45VRK11.21370439
46PDPK11.18799441
47MUSK1.17489369
48PDK11.17100764
49MAP4K21.14788138
50KSR21.13487016
51MET1.12783281
52PAK61.12001154
53MARK31.06115831
54CHEK10.98261197
55DYRK1A0.94329650
56TIE10.94092785
57WNK10.92160124
58CAMK1D0.89253997
59CDK90.88919528
60CSNK1G10.87504761
61NEK60.86455119
62PRKAA20.86158246
63CDK70.85693017
64MKNK10.85651718
65IRAK30.85187211
66NLK0.84644306
67RAF10.83315553
68MAPK130.82941990
69EIF2AK20.81210246
70CDK40.80615725
71ATM0.80126532
72TAOK30.79592740
73KSR10.75330884
74PRKG10.74623365
75STK240.74357441
76MAP2K70.73178787
77PRKAA10.73007719
78SGK20.72287309
79MAP3K40.72216586
80MELK0.72044512
81MYLK0.71955745
82MAPK100.71799650
83BMPR1B0.70491824
84EPHA40.69393621
85JAK30.68153533
86HIPK20.66989495
87CDK20.65102523
88MST1R0.64896712
89CDK80.61320992
90CDK10.57955307
91CAMK10.57335876
92PTK2B0.53854607
93TNIK0.53238796
94MAP3K80.53154929
95AKT30.51502467
96TLK10.50865068
97PDGFRB0.49997241
98STK390.49342009
99CSNK1G20.48511206
100DYRK1B0.47839247
101OBSCN0.46636624
102AURKA0.46321281
103ABL10.46272140
104PRKG20.45740706
105PRKCI0.45280908
106ATR0.44156735
107BLK0.43176847
108SGK2230.42463914
109SGK4940.42463914
110MTOR0.40670099
111NTRK30.38150750
112CAMK1G0.37301313
113CDK190.36148441
114MAP2K40.34228380
115NTRK20.31408787
116PRKACA0.30202163
117MAP3K50.29974654
118MAPK140.29198080
119CSNK1D0.29182179
120ZAK0.28837469
121CSNK1G30.28649591
122RPS6KA10.28644389
123GSK3B0.28586595
124PRKCZ0.28013323
125PKN10.26771272
126TAOK10.26479517
127CAMK2A0.26138496
128NUAK10.26125222
129SGK10.25826195
130RPS6KA40.25423238
131ROCK10.24616406
132KDR0.24210432
133TRPM70.23991917
134PRKACB0.23166769
135JAK20.22067044
136EEF2K0.21692444
137CSNK1A1L0.21548195
138DMPK0.21453487
139SGK30.20617191
140ERBB20.19769867
141MAP3K10.19238192
142PAK10.18697233
143MAPK10.14702192
144OXSR10.13558698
145CSNK1E0.13029947
146CDK60.12050153
147EIF2AK30.11780281
148ALK0.11103094
149PLK20.10938812
150PIM10.10090865

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.53239915
2Olfactory transduction_Homo sapiens_hsa047404.37246574
3RNA polymerase_Homo sapiens_hsa030204.22245274
4Cell cycle_Homo sapiens_hsa041104.10739161
5Pentose phosphate pathway_Homo sapiens_hsa000303.93216834
6Vitamin B6 metabolism_Homo sapiens_hsa007503.87743154
7Basal transcription factors_Homo sapiens_hsa030223.73842005
8Fanconi anemia pathway_Homo sapiens_hsa034603.35581746
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20331600
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19630291
11Homologous recombination_Homo sapiens_hsa034402.77625593
12Circadian rhythm_Homo sapiens_hsa047102.32266685
13RNA transport_Homo sapiens_hsa030132.30232373
14p53 signaling pathway_Homo sapiens_hsa041152.17483036
15Gap junction_Homo sapiens_hsa045402.07662956
16RNA degradation_Homo sapiens_hsa030182.01121689
17Oocyte meiosis_Homo sapiens_hsa041141.99546110
18Taste transduction_Homo sapiens_hsa047421.98676693
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92726913
20mRNA surveillance pathway_Homo sapiens_hsa030151.88950442
21TGF-beta signaling pathway_Homo sapiens_hsa043501.66156560
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58803471
23Caffeine metabolism_Homo sapiens_hsa002321.50559061
24Morphine addiction_Homo sapiens_hsa050321.47310514
25Base excision repair_Homo sapiens_hsa034101.43997523
26MicroRNAs in cancer_Homo sapiens_hsa052061.42624612
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37671258
28Sphingolipid metabolism_Homo sapiens_hsa006001.37417390
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36113626
30Biosynthesis of amino acids_Homo sapiens_hsa012301.30032430
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25964926
32Herpes simplex infection_Homo sapiens_hsa051681.24239345
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23292487
34Pancreatic cancer_Homo sapiens_hsa052121.21313082
35Spliceosome_Homo sapiens_hsa030401.21306048
36Purine metabolism_Homo sapiens_hsa002301.20698909
37Selenocompound metabolism_Homo sapiens_hsa004501.20674702
38ABC transporters_Homo sapiens_hsa020101.15844338
39Choline metabolism in cancer_Homo sapiens_hsa052311.15750829
40Renal cell carcinoma_Homo sapiens_hsa052111.15295649
41Serotonergic synapse_Homo sapiens_hsa047261.14159100
42Pyrimidine metabolism_Homo sapiens_hsa002401.13510476
43Circadian entrainment_Homo sapiens_hsa047131.12155035
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11886295
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.10912979
46Butanoate metabolism_Homo sapiens_hsa006501.10818390
47Synaptic vesicle cycle_Homo sapiens_hsa047211.09917996
48GABAergic synapse_Homo sapiens_hsa047271.04994087
49Propanoate metabolism_Homo sapiens_hsa006401.04596046
50Bile secretion_Homo sapiens_hsa049760.99891832
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99811805
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99476572
53Calcium signaling pathway_Homo sapiens_hsa040200.98874909
54Dorso-ventral axis formation_Homo sapiens_hsa043200.98827608
55Prostate cancer_Homo sapiens_hsa052150.98728824
56Nucleotide excision repair_Homo sapiens_hsa034200.93856161
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93171916
58FoxO signaling pathway_Homo sapiens_hsa040680.91524535
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.90670694
60Ether lipid metabolism_Homo sapiens_hsa005650.89089339
61Fatty acid degradation_Homo sapiens_hsa000710.86822032
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86173501
63Salivary secretion_Homo sapiens_hsa049700.85361688
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83677780
65Prolactin signaling pathway_Homo sapiens_hsa049170.83081335
66Protein digestion and absorption_Homo sapiens_hsa049740.82965596
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.82324819
68Renin secretion_Homo sapiens_hsa049240.81873806
69Phenylalanine metabolism_Homo sapiens_hsa003600.80479398
70Gastric acid secretion_Homo sapiens_hsa049710.79884860
71Epstein-Barr virus infection_Homo sapiens_hsa051690.79411845
72Oxytocin signaling pathway_Homo sapiens_hsa049210.78662751
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.77306593
74Hepatitis B_Homo sapiens_hsa051610.75895264
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.75800863
76Cocaine addiction_Homo sapiens_hsa050300.75310172
77Amphetamine addiction_Homo sapiens_hsa050310.73368142
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72502222
79Cholinergic synapse_Homo sapiens_hsa047250.71794409
80Nitrogen metabolism_Homo sapiens_hsa009100.71552634
81Adherens junction_Homo sapiens_hsa045200.71524296
82Vitamin digestion and absorption_Homo sapiens_hsa049770.70768123
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70349287
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.69595595
85Arginine and proline metabolism_Homo sapiens_hsa003300.69025082
86Nicotine addiction_Homo sapiens_hsa050330.67604912
87Cardiac muscle contraction_Homo sapiens_hsa042600.67217286
88Mismatch repair_Homo sapiens_hsa034300.65235500
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65205494
90Thyroid cancer_Homo sapiens_hsa052160.65028413
91Lysine degradation_Homo sapiens_hsa003100.63543364
92Insulin secretion_Homo sapiens_hsa049110.63219486
93Steroid biosynthesis_Homo sapiens_hsa001000.62950087
94Small cell lung cancer_Homo sapiens_hsa052220.62702115
95PPAR signaling pathway_Homo sapiens_hsa033200.62549951
96Glucagon signaling pathway_Homo sapiens_hsa049220.60545913
97Ovarian steroidogenesis_Homo sapiens_hsa049130.60149929
98Linoleic acid metabolism_Homo sapiens_hsa005910.59236660
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55185495
100cAMP signaling pathway_Homo sapiens_hsa040240.53430775
101Influenza A_Homo sapiens_hsa051640.52794613
102Fatty acid metabolism_Homo sapiens_hsa012120.52706589
103Colorectal cancer_Homo sapiens_hsa052100.52562391
104Viral carcinogenesis_Homo sapiens_hsa052030.51557663
105Endometrial cancer_Homo sapiens_hsa052130.51256555
106mTOR signaling pathway_Homo sapiens_hsa041500.50242682
107GnRH signaling pathway_Homo sapiens_hsa049120.49719522
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48794344
109Inositol phosphate metabolism_Homo sapiens_hsa005620.48234097
110Pancreatic secretion_Homo sapiens_hsa049720.47389792
111Arginine biosynthesis_Homo sapiens_hsa002200.46379819
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45362843
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44004479
114Wnt signaling pathway_Homo sapiens_hsa043100.43353359
115Long-term potentiation_Homo sapiens_hsa047200.42896217
116Pathways in cancer_Homo sapiens_hsa052000.42542586
117MAPK signaling pathway_Homo sapiens_hsa040100.41954923
118ErbB signaling pathway_Homo sapiens_hsa040120.41756672
119Long-term depression_Homo sapiens_hsa047300.41524676
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39872469
121Type II diabetes mellitus_Homo sapiens_hsa049300.39623904
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38048474
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38015406
124Phagosome_Homo sapiens_hsa041450.37670907
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37509419
126AMPK signaling pathway_Homo sapiens_hsa041520.37424444
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36998381
128Hippo signaling pathway_Homo sapiens_hsa043900.36198627
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.35067634
130Basal cell carcinoma_Homo sapiens_hsa052170.34249602
131Chemical carcinogenesis_Homo sapiens_hsa052040.33522313
132Tryptophan metabolism_Homo sapiens_hsa003800.33403734
133Arachidonic acid metabolism_Homo sapiens_hsa005900.32533289
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31919196
135Regulation of autophagy_Homo sapiens_hsa041400.31145224
136DNA replication_Homo sapiens_hsa030300.30784054
137Glutamatergic synapse_Homo sapiens_hsa047240.29835767
138Rheumatoid arthritis_Homo sapiens_hsa053230.29503465
139ECM-receptor interaction_Homo sapiens_hsa045120.28973600
140Thyroid hormone synthesis_Homo sapiens_hsa049180.28020773
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.28004789
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27815580
143Ras signaling pathway_Homo sapiens_hsa040140.27066156
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.26575695
145Phototransduction_Homo sapiens_hsa047440.25796751
146Insulin resistance_Homo sapiens_hsa049310.25596474
147Estrogen signaling pathway_Homo sapiens_hsa049150.24856969
148Chemokine signaling pathway_Homo sapiens_hsa040620.24740715
149Glycerolipid metabolism_Homo sapiens_hsa005610.24297776
150Dilated cardiomyopathy_Homo sapiens_hsa054140.24029580
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23982663
152Jak-STAT signaling pathway_Homo sapiens_hsa046300.23855403
153Huntingtons disease_Homo sapiens_hsa050160.23673913
154HTLV-I infection_Homo sapiens_hsa051660.23035941
155Measles_Homo sapiens_hsa051620.22197194
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22167818
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.22125341
158Hedgehog signaling pathway_Homo sapiens_hsa043400.21998005
159Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21614579

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