DCHS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)4.90530848
2dendritic spine morphogenesis (GO:0060997)4.42903972
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41927127
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25592558
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08431773
6cilium or flagellum-dependent cell motility (GO:0001539)4.06173053
7regulation of synapse structural plasticity (GO:0051823)3.99900789
8locomotory exploration behavior (GO:0035641)3.91720493
9regulation of glutamate receptor signaling pathway (GO:1900449)3.87961468
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87653902
11retinal cone cell development (GO:0046549)3.84004944
12neuron cell-cell adhesion (GO:0007158)3.73062197
13layer formation in cerebral cortex (GO:0021819)3.60220088
14protein polyglutamylation (GO:0018095)3.59506620
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57931012
16serotonin metabolic process (GO:0042428)3.55132837
17protein localization to synapse (GO:0035418)3.49333664
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.48627734
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47306995
20neuronal action potential (GO:0019228)3.43331186
21postsynaptic membrane organization (GO:0001941)3.42657911
22regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.41530083
23DNA methylation involved in gamete generation (GO:0043046)3.41254035
24exploration behavior (GO:0035640)3.37902246
25positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.37616537
26gamma-aminobutyric acid signaling pathway (GO:0007214)3.37607832
27axonal fasciculation (GO:0007413)3.36188998
28startle response (GO:0001964)3.36162836
29establishment of nucleus localization (GO:0040023)3.34121182
30neuron recognition (GO:0008038)3.29399648
31regulation of dendritic spine morphogenesis (GO:0061001)3.27390048
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26440627
33regulation of axon extension involved in axon guidance (GO:0048841)3.25760968
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25054891
35neurotransmitter-gated ion channel clustering (GO:0072578)3.24494365
36dendrite morphogenesis (GO:0048813)3.23007233
37primary amino compound metabolic process (GO:1901160)3.22738147
38regulation of acrosome reaction (GO:0060046)3.16788109
39central nervous system projection neuron axonogenesis (GO:0021952)3.15758029
40regulation of neuronal synaptic plasticity (GO:0048168)3.14026664
41synaptic vesicle maturation (GO:0016188)3.13812225
42centriole replication (GO:0007099)3.12242503
43interkinetic nuclear migration (GO:0022027)3.11670162
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07692507
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06028893
46photoreceptor cell maintenance (GO:0045494)3.04186394
47neurotransmitter secretion (GO:0007269)3.03911504
48regulation of axon guidance (GO:1902667)3.03801046
49response to auditory stimulus (GO:0010996)3.03763763
50auditory behavior (GO:0031223)3.03377345
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01772680
52presynaptic membrane organization (GO:0097090)2.99399575
53proline transport (GO:0015824)2.99351200
54prepulse inhibition (GO:0060134)2.98722539
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97841554
56synaptic vesicle docking involved in exocytosis (GO:0016081)2.97399257
57synaptic vesicle exocytosis (GO:0016079)2.94262478
58tachykinin receptor signaling pathway (GO:0007217)2.91891255
59sensory perception of smell (GO:0007608)2.91630256
60regulation of synaptic vesicle exocytosis (GO:2000300)2.90924395
61glutamate receptor signaling pathway (GO:0007215)2.90825799
62nerve growth factor signaling pathway (GO:0038180)2.90420659
63monoubiquitinated protein deubiquitination (GO:0035520)2.89917667
64synaptic transmission, glutamatergic (GO:0035249)2.89464913
65regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88345003
66behavioral response to ethanol (GO:0048149)2.86434110
67cell migration in hindbrain (GO:0021535)2.86176485
68negative regulation of catenin import into nucleus (GO:0035414)2.84855982
69neuron-neuron synaptic transmission (GO:0007270)2.84843883
70response to pheromone (GO:0019236)2.83825025
71dendritic spine organization (GO:0097061)2.83581106
72pyrimidine nucleobase catabolic process (GO:0006208)2.81876504
73detection of mechanical stimulus involved in sensory perception (GO:0050974)2.81848736
74regulation of postsynaptic membrane potential (GO:0060078)2.81387994
75positive regulation of synapse maturation (GO:0090129)2.80769580
76regulation of respiratory system process (GO:0044065)2.80756661
77acrosome reaction (GO:0007340)2.80676917
78neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.79167686
79neuronal ion channel clustering (GO:0045161)2.78616543
80positive regulation of dendritic spine morphogenesis (GO:0061003)2.77879657
81regulation of female gonad development (GO:2000194)2.77741219
82axon ensheathment in central nervous system (GO:0032291)2.77386297
83central nervous system myelination (GO:0022010)2.77386297
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.74949453
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74572571
86detection of light stimulus involved in visual perception (GO:0050908)2.73685864
87detection of light stimulus involved in sensory perception (GO:0050962)2.73685864
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.73537874
89axon extension involved in axon guidance (GO:0048846)2.73537874
90synapse assembly (GO:0007416)2.73499730
91indole-containing compound metabolic process (GO:0042430)2.71832174
92microtubule polymerization or depolymerization (GO:0031109)2.71714393
93neuromuscular process controlling posture (GO:0050884)2.70985279
94resolution of meiotic recombination intermediates (GO:0000712)2.70948531
95nucleus localization (GO:0051647)2.70517463
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70290749
97positive regulation of synapse assembly (GO:0051965)2.70051905
98indolalkylamine metabolic process (GO:0006586)2.69219007
99cochlea development (GO:0090102)2.69195204
100gamma-aminobutyric acid transport (GO:0015812)2.68800802
101axon extension (GO:0048675)2.68567534
102neuromuscular process controlling balance (GO:0050885)2.67936836
103regulation of dendritic spine development (GO:0060998)2.67742020
104regulation of meiosis I (GO:0060631)2.67444610
105behavioral response to nicotine (GO:0035095)2.67392555
106multicellular organism reproduction (GO:0032504)2.67266969
107membrane hyperpolarization (GO:0060081)2.65955621
108activation of protein kinase A activity (GO:0034199)2.65176744
109one-carbon compound transport (GO:0019755)2.64904189
110piRNA metabolic process (GO:0034587)2.64766434
111glycine transport (GO:0015816)2.64666677
112positive regulation of dendritic spine development (GO:0060999)2.64446680
113nonmotile primary cilium assembly (GO:0035058)2.63202779
114righting reflex (GO:0060013)2.63065661
115establishment of protein localization to Golgi (GO:0072600)2.62791376
116negative regulation of axon extension involved in axon guidance (GO:0048843)2.62726402
117cerebellar Purkinje cell layer development (GO:0021680)2.61518325
118presynaptic membrane assembly (GO:0097105)2.61030876
119microtubule anchoring (GO:0034453)2.59576340
120glutamate secretion (GO:0014047)2.58747461
121regulation of synaptic vesicle transport (GO:1902803)2.57725644
122regulation of synapse assembly (GO:0051963)2.57658751
123transmission of nerve impulse (GO:0019226)2.57039356
124positive regulation of membrane potential (GO:0045838)2.56747950
125synapse organization (GO:0050808)2.56408757
126protein K11-linked deubiquitination (GO:0035871)2.56332039
127protein heterotrimerization (GO:0070208)2.56050351
128striatum development (GO:0021756)2.53975473
129regulation of respiratory gaseous exchange (GO:0043576)2.53545358
130phosphorelay signal transduction system (GO:0000160)2.53366187
131long-term memory (GO:0007616)2.52806198
132positive regulation of fibroblast migration (GO:0010763)2.52729852
133regulation of protein kinase A signaling (GO:0010738)2.52644802
134neurotransmitter transport (GO:0006836)2.52202349
135innervation (GO:0060384)2.52070014
136mechanosensory behavior (GO:0007638)2.51944001
137neuronal action potential propagation (GO:0019227)2.51403648
138regulation of synaptic transmission, GABAergic (GO:0032228)2.51325798
139microtubule severing (GO:0051013)2.51231998
140regulation of hippo signaling (GO:0035330)2.50802077
141regulation of synapse organization (GO:0050807)2.50208368
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50185764
143reflex (GO:0060004)2.49496235
144membrane depolarization during action potential (GO:0086010)2.49222031
145membrane depolarization (GO:0051899)2.47474271
146inner ear receptor stereocilium organization (GO:0060122)2.47448046
147G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.45598370
148regulation of timing of cell differentiation (GO:0048505)2.45523196
149axoneme assembly (GO:0035082)2.44658078
150C4-dicarboxylate transport (GO:0015740)2.44636071
151regulation of membrane repolarization (GO:0060306)2.44006509
152epithelial cilium movement (GO:0003351)2.43905882
153neuromuscular process (GO:0050905)2.43213829
154calcium ion-dependent exocytosis (GO:0017156)2.42536410
155retinal ganglion cell axon guidance (GO:0031290)2.42387550
156* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.42326271
157cilium movement (GO:0003341)2.42017431
158nucleobase catabolic process (GO:0046113)2.41931333
159adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.41149759
160central nervous system neuron axonogenesis (GO:0021955)2.40846539
161neuron fate determination (GO:0048664)2.40507220
162tryptophan catabolic process (GO:0006569)2.40078117
163indole-containing compound catabolic process (GO:0042436)2.40078117
164indolalkylamine catabolic process (GO:0046218)2.40078117
165regulation of pigment cell differentiation (GO:0050932)2.36914365
166negative regulation of oligodendrocyte differentiation (GO:0048715)2.35543899
167neural tube formation (GO:0001841)2.35517320
168regulation of calcium ion-dependent exocytosis (GO:0017158)2.35344021
169cAMP catabolic process (GO:0006198)2.34745942
170smooth muscle contraction (GO:0006939)2.32580432
171detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.32550706
172cilium organization (GO:0044782)2.31791569
173multicellular organismal movement (GO:0050879)2.31327012
174musculoskeletal movement (GO:0050881)2.31327012
175dopamine biosynthetic process (GO:0042416)2.31175660
176cilium assembly (GO:0042384)2.30127792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83427303
2GBX2_23144817_ChIP-Seq_PC3_Human3.54689526
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.29508497
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95791553
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88809911
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86005719
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74524024
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74524024
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60594285
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60199182
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.56239245
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.56153830
13VDR_22108803_ChIP-Seq_LS180_Human2.55568826
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50977585
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49949114
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27247132
17DROSHA_22980978_ChIP-Seq_HELA_Human2.14327725
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13607223
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.12779967
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.12318440
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.10491705
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08278905
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91537049
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83522652
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82134584
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81340988
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80080593
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78896981
29AR_21572438_ChIP-Seq_LNCaP_Human1.70156690
30EWS_26573619_Chip-Seq_HEK293_Human1.69504397
31REST_21632747_ChIP-Seq_MESCs_Mouse1.67078433
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66914453
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66300363
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65928869
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.65675998
36ER_23166858_ChIP-Seq_MCF-7_Human1.64576900
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63295805
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62597347
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62491779
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62219141
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60823064
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.59086947
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.58451812
44SMAD4_21799915_ChIP-Seq_A2780_Human1.51862852
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.49449411
46BCAT_22108803_ChIP-Seq_LS180_Human1.48040753
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.46321784
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.42744043
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42190387
50* P300_19829295_ChIP-Seq_ESCs_Human1.40618752
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39911971
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38860936
53* CBP_20019798_ChIP-Seq_JUKART_Human1.37709111
54* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37709111
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36746504
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36460238
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36437873
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36320390
59* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36293067
60ZNF274_21170338_ChIP-Seq_K562_Hela1.36071103
61TAF15_26573619_Chip-Seq_HEK293_Human1.32805735
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.31200900
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30325006
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.26869083
65TP53_18474530_ChIP-ChIP_U2OS_Human1.26644042
66IGF1R_20145208_ChIP-Seq_DFB_Human1.26424516
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.25034399
68* STAT3_23295773_ChIP-Seq_U87_Human1.24705518
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.23400495
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.22409672
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21094629
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20765178
73AHR_22903824_ChIP-Seq_MCF-7_Human1.20444546
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19600576
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.19558539
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.18597275
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.18509487
78AR_19668381_ChIP-Seq_PC3_Human1.17102774
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16743148
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16648338
81* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16623646
82TCF4_22108803_ChIP-Seq_LS180_Human1.16459698
83AR_25329375_ChIP-Seq_VCAP_Human1.16274865
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15771994
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15760646
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15687851
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15145755
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14166286
89JUN_21703547_ChIP-Seq_K562_Human1.13548862
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13097881
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12787308
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.12669879
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12289071
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12033800
95P53_22387025_ChIP-Seq_ESCs_Mouse1.10997548
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09375661
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09317054
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09142211
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.08855710
100* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08714632
101TBL1_22424771_ChIP-Seq_293T_Human1.08610799
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.07411854
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07072713
104RNF2_27304074_Chip-Seq_NSC_Mouse1.06718545
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06490873
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.06125332
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.05434527
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.05257412
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03885543
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03018592
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02397816
112* TCF4_23295773_ChIP-Seq_U87_Human1.01492413
113NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01486505
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01486505
115* NANOG_19829295_ChIP-Seq_ESCs_Human1.01050761
116* SOX2_19829295_ChIP-Seq_ESCs_Human1.01050761
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.00683827
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00295382
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99202530
120TP53_16413492_ChIP-PET_HCT116_Human0.99092453
121FUS_26573619_Chip-Seq_HEK293_Human0.97738494
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.97578125
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.97174876
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96941478
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96726535
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96726535
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95983863
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95876470
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95766369
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95247480
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94644700
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92951373
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92382580
134* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90202914
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89677200
136KDM2B_26808549_Chip-Seq_REH_Human0.89460049
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.88352035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.55887312
2MP0003880_abnormal_central_pattern3.60463493
3MP0002822_catalepsy3.58052653
4MP0003635_abnormal_synaptic_transmissio3.14924214
5MP0003283_abnormal_digestive_organ3.14150728
6MP0005503_abnormal_tendon_morphology3.08043649
7MP0003950_abnormal_plasma_membrane2.82635361
8MP0003136_yellow_coat_color2.64919077
9MP0009745_abnormal_behavioral_response2.64149446
10MP0008438_abnormal_cutaneous_collagen2.58135743
11MP0002063_abnormal_learning/memory/cond2.49061819
12MP0005423_abnormal_somatic_nervous2.47752450
13MP0001486_abnormal_startle_reflex2.44144432
14MP0004270_analgesia2.29746359
15MP0009046_muscle_twitch2.27994102
16MP0001188_hyperpigmentation2.20136087
17MP0002064_seizures2.15111628
18MP0002572_abnormal_emotion/affect_behav2.10139574
19MP0005275_abnormal_skin_tensile2.08278518
20MP0006276_abnormal_autonomic_nervous2.00319045
21MP0008877_abnormal_DNA_methylation1.99711023
22MP0005551_abnormal_eye_electrophysiolog1.96810277
23MP0003879_abnormal_hair_cell1.94146755
24MP0008057_abnormal_DNA_replication1.93845524
25MP0003122_maternal_imprinting1.90962974
26MP0001968_abnormal_touch/_nociception1.90302574
27MP0001984_abnormal_olfaction1.86807754
28MP0000778_abnormal_nervous_system1.84430839
29MP0002184_abnormal_innervation1.83056772
30MP0000569_abnormal_digit_pigmentation1.80557494
31MP0009780_abnormal_chondrocyte_physiolo1.76617516
32MP0000751_myopathy1.75625994
33MP0003718_maternal_effect1.68145128
34MP0002734_abnormal_mechanical_nocicepti1.66162812
35MP0002272_abnormal_nervous_system1.65342384
36MP0002108_abnormal_muscle_morphology1.62734289
37MP0001501_abnormal_sleep_pattern1.61794112
38MP0008995_early_reproductive_senescence1.59985258
39MP0005257_abnormal_intraocular_pressure1.59262945
40MP0004272_abnormal_basement_membrane1.56575960
41MP0002735_abnormal_chemical_nociception1.56451262
42MP0005623_abnormal_meninges_morphology1.55800771
43MP0002653_abnormal_ependyma_morphology1.55769523
44MP0003890_abnormal_embryonic-extraembry1.55286541
45MP0000427_abnormal_hair_cycle1.53826277
46MP0002557_abnormal_social/conspecific_i1.50377540
47MP0001958_emphysema1.48612841
48MP0001440_abnormal_grooming_behavior1.47937447
49MP0002067_abnormal_sensory_capabilities1.46044434
50MP0003385_abnormal_body_wall1.45408346
51MP0001177_atelectasis1.43163830
52MP0005171_absent_coat_pigmentation1.41426050
53MP0005410_abnormal_fertilization1.41390602
54MP0002928_abnormal_bile_duct1.39798746
55MP0005386_behavior/neurological_phenoty1.36042151
56MP0004924_abnormal_behavior1.36042151
57MP0001299_abnormal_eye_distance/1.34078321
58MP0000955_abnormal_spinal_cord1.32719368
59MP0002736_abnormal_nociception_after1.27461654
60MP0004147_increased_porphyrin_level1.27412174
61MP0002733_abnormal_thermal_nociception1.26560679
62MP0005253_abnormal_eye_physiology1.24665728
63MP0005645_abnormal_hypothalamus_physiol1.24174213
64MP0008789_abnormal_olfactory_epithelium1.20041427
65MP0001929_abnormal_gametogenesis1.19768504
66MP0003195_calcinosis1.19669054
67MP0003646_muscle_fatigue1.17832649
68MP0003045_fibrosis1.15460117
69MP0001970_abnormal_pain_threshold1.15288829
70MP0003698_abnormal_male_reproductive1.15275128
71MP0004811_abnormal_neuron_physiology1.14738042
72MP0004043_abnormal_pH_regulation1.14663696
73MP0008569_lethality_at_weaning1.13754717
74MP0004484_altered_response_of1.13689595
75MP0003633_abnormal_nervous_system1.12124532
76MP0002909_abnormal_adrenal_gland1.11502204
77MP0001529_abnormal_vocalization1.09441926
78MP0002882_abnormal_neuron_morphology1.09278084
79MP0000372_irregular_coat_pigmentation1.07898658
80MP0004858_abnormal_nervous_system1.05997573
81MP0005395_other_phenotype1.05010815
82MP0002752_abnormal_somatic_nervous1.04363705
83MP0005646_abnormal_pituitary_gland1.03957239
84MP0002066_abnormal_motor_capabilities/c1.03246309
85MP0000383_abnormal_hair_follicle1.02466325
86MP0004085_abnormal_heartbeat1.02421974
87MP0003941_abnormal_skin_development0.99500851
88MP0001963_abnormal_hearing_physiology0.98791478
89MP0004742_abnormal_vestibular_system0.97146500
90MP0002234_abnormal_pharynx_morphology0.97073405
91MP0005174_abnormal_tail_pigmentation0.96845569
92MP0002210_abnormal_sex_determination0.95441691
93MP0003631_nervous_system_phenotype0.95301739
94MP0005394_taste/olfaction_phenotype0.92920602
95MP0005499_abnormal_olfactory_system0.92920602
96MP0000534_abnormal_ureter_morphology0.92878866
97MP0003137_abnormal_impulse_conducting0.92826271
98MP0002152_abnormal_brain_morphology0.92408999
99MP0002102_abnormal_ear_morphology0.92389556
100MP0002229_neurodegeneration0.91017628
101MP0003937_abnormal_limbs/digits/tail_de0.90942970
102MP0004215_abnormal_myocardial_fiber0.90820262
103MP0004145_abnormal_muscle_electrophysio0.89708971
104MP0009250_abnormal_appendicular_skeleto0.89457424
105MP0000013_abnormal_adipose_tissue0.89066492
106MP0005508_abnormal_skeleton_morphology0.86905270
107MP0004885_abnormal_endolymph0.86529167
108MP0004142_abnormal_muscle_tone0.86263180
109MP0003632_abnormal_nervous_system0.83657613
110MP0008961_abnormal_basal_metabolism0.82867635
111MP0000631_abnormal_neuroendocrine_gland0.81073008
112MP0010386_abnormal_urinary_bladder0.80948109
113MP0005187_abnormal_penis_morphology0.79977513
114MP0000647_abnormal_sebaceous_gland0.79263363
115MP0002638_abnormal_pupillary_reflex0.79204980
116MP0001485_abnormal_pinna_reflex0.78977059
117MP0002168_other_aberrant_phenotype0.78749222
118MP0005195_abnormal_posterior_eye0.78746234
119MP0000462_abnormal_digestive_system0.78047016
120MP0002837_dystrophic_cardiac_calcinosis0.73495086
121MP0005620_abnormal_muscle_contractility0.72083209
122MP0003942_abnormal_urinary_system0.72075697
123MP0001502_abnormal_circadian_rhythm0.72026747
124MP0004134_abnormal_chest_morphology0.71666496
125MP0002116_abnormal_craniofacial_bone0.70628771
126MP0003861_abnormal_nervous_system0.69379103
127MP0001943_abnormal_respiration0.68658572
128MP0003119_abnormal_digestive_system0.65705037
129MP0000579_abnormal_nail_morphology0.64099530
130MP0000537_abnormal_urethra_morphology0.63770508
131MP0003121_genomic_imprinting0.63643816
132MP0002069_abnormal_eating/drinking_beha0.62724817
133MP0002133_abnormal_respiratory_system0.61322953
134MP0005388_respiratory_system_phenotype0.61322953
135MP0002089_abnormal_postnatal_growth/wei0.61257932
136MP0002751_abnormal_autonomic_nervous0.61084600
137MP0005369_muscle_phenotype0.60916230
138MP0002896_abnormal_bone_mineralization0.60788694
139MP0004133_heterotaxia0.60685922
140MP0005248_abnormal_Harderian_gland0.60637249
141MP0000026_abnormal_inner_ear0.60484534

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.17892855
2Focal seizures (HP:0007359)4.60838565
3Myokymia (HP:0002411)3.91439310
4Pancreatic cysts (HP:0001737)3.81712523
5Pancreatic fibrosis (HP:0100732)3.54897247
6Visual hallucinations (HP:0002367)3.54861434
7Chronic hepatic failure (HP:0100626)3.44328333
8Neoplasm of the heart (HP:0100544)3.17708549
9True hermaphroditism (HP:0010459)3.17348412
10Absence seizures (HP:0002121)3.07353714
11Febrile seizures (HP:0002373)3.06456289
12Medial flaring of the eyebrow (HP:0010747)3.05723882
13Gait imbalance (HP:0002141)2.93327205
14Type 1 muscle fiber predominance (HP:0003803)2.89128791
15Generalized tonic-clonic seizures (HP:0002069)2.84182548
16Lower limb amyotrophy (HP:0007210)2.83438090
17Broad metatarsal (HP:0001783)2.80510374
18Abnormality of midbrain morphology (HP:0002418)2.78012403
19Molar tooth sign on MRI (HP:0002419)2.78012403
20Torticollis (HP:0000473)2.75094794
21Dialeptic seizures (HP:0011146)2.74962965
22Genital tract atresia (HP:0001827)2.71884233
23Congenital primary aphakia (HP:0007707)2.71805781
24Protrusio acetabuli (HP:0003179)2.70854947
25Shallow orbits (HP:0000586)2.66194626
26Prolonged QT interval (HP:0001657)2.66150283
27Premature rupture of membranes (HP:0001788)2.65796567
28Congenital sensorineural hearing impairment (HP:0008527)2.65178568
29Tubulointerstitial nephritis (HP:0001970)2.64936370
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.64590032
31Attenuation of retinal blood vessels (HP:0007843)2.64460894
32Abnormality of the renal cortex (HP:0011035)2.57442055
33Abnormality of the renal medulla (HP:0100957)2.55550634
34Nephronophthisis (HP:0000090)2.54724140
35Broad-based gait (HP:0002136)2.54697043
36Protruding tongue (HP:0010808)2.53987220
37Bronchomalacia (HP:0002780)2.52764954
38Vaginal atresia (HP:0000148)2.51276894
39Hypoventilation (HP:0002791)2.50419986
40Follicular hyperkeratosis (HP:0007502)2.47918278
41Central scotoma (HP:0000603)2.47494780
42Absent/shortened dynein arms (HP:0200106)2.47424040
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.47424040
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.46814610
45Cerebral aneurysm (HP:0004944)2.45954455
46Flat cornea (HP:0007720)2.43402550
47Cystic liver disease (HP:0006706)2.43107212
48Nephrogenic diabetes insipidus (HP:0009806)2.37878798
49Tubulointerstitial abnormality (HP:0001969)2.37557669
50Increased corneal curvature (HP:0100692)2.36333389
51Keratoconus (HP:0000563)2.36333389
52Poor coordination (HP:0002370)2.35160438
53Fair hair (HP:0002286)2.34547415
54Dysmetric saccades (HP:0000641)2.33016871
55Drooling (HP:0002307)2.31918626
56Excessive salivation (HP:0003781)2.31918626
57Action tremor (HP:0002345)2.30426195
58Abnormality of macular pigmentation (HP:0008002)2.30391959
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28484344
60Short 4th metacarpal (HP:0010044)2.28484344
61Bladder diverticulum (HP:0000015)2.27561535
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.26345306
63Hypoplastic labia majora (HP:0000059)2.22952095
64Bony spicule pigmentary retinopathy (HP:0007737)2.22445717
65Slender build (HP:0001533)2.21845785
66Turricephaly (HP:0000262)2.20551782
67Fragile skin (HP:0001030)2.20395773
68Progressive cerebellar ataxia (HP:0002073)2.20373601
69Atonic seizures (HP:0010819)2.20266736
70Abnormality of the labia minora (HP:0012880)2.19208817
71Small hand (HP:0200055)2.18925180
72Abnormal EKG (HP:0003115)2.17537914
73Abnormal ciliary motility (HP:0012262)2.16036780
74Fetal akinesia sequence (HP:0001989)2.15972766
75Ankle contracture (HP:0006466)2.15412660
76Increased variability in muscle fiber diameter (HP:0003557)2.14152560
77Elfin facies (HP:0004428)2.13901586
78Atrophic scars (HP:0001075)2.13608580
79Focal dystonia (HP:0004373)2.11713329
80Distal lower limb amyotrophy (HP:0008944)2.11092310
81Abnormality of the ischium (HP:0003174)2.10541778
82Supernumerary spleens (HP:0009799)2.10032155
83Short foot (HP:0001773)2.08965368
84Abnormality of the labia majora (HP:0012881)2.07612896
85Ankle clonus (HP:0011448)2.06742687
86Abnormality of the right ventricle (HP:0001707)2.05421593
87Volvulus (HP:0002580)2.03548479
88Craniofacial dystonia (HP:0012179)2.03230300
89Papillary thyroid carcinoma (HP:0002895)2.02809500
90Epileptic encephalopathy (HP:0200134)2.00581047
91Striae distensae (HP:0001065)2.00379060
92Abnormality of the 4th metacarpal (HP:0010012)1.99978481
93Aortic dissection (HP:0002647)1.99585464
94Cutaneous finger syndactyly (HP:0010554)1.98693529
95Truncal obesity (HP:0001956)1.98164722
96Hypoplastic ischia (HP:0003175)1.98038250
97Spinal rigidity (HP:0003306)1.97642807
98Aplasia involving bones of the upper limbs (HP:0009823)1.97475298
99Aplasia of the phalanges of the hand (HP:0009802)1.97475298
100Aplasia involving bones of the extremities (HP:0009825)1.97475298
101Intestinal atresia (HP:0011100)1.96685431
102Ankyloglossia (HP:0010296)1.96452359
103Congenital stationary night blindness (HP:0007642)1.95432512
104Sclerocornea (HP:0000647)1.95367221
105Renovascular hypertension (HP:0100817)1.94607733
106Ulnar claw (HP:0001178)1.94414793
107Truncal ataxia (HP:0002078)1.94032236
108Hyperventilation (HP:0002883)1.93221571
109Gonadotropin excess (HP:0000837)1.93111116
110Absent speech (HP:0001344)1.92847496
111Glioma (HP:0009733)1.92343422
112Cutaneous syndactyly (HP:0012725)1.90612415
113Midline defect of the nose (HP:0004122)1.90002494
114Poor eye contact (HP:0000817)1.89833089
115Astrocytoma (HP:0009592)1.88367952
116Abnormality of the astrocytes (HP:0100707)1.88367952
117Blue irides (HP:0000635)1.88006043
118Limb dystonia (HP:0002451)1.87485053
119Coronal craniosynostosis (HP:0004440)1.87370408
120Optic nerve hypoplasia (HP:0000609)1.87310772
121Bradycardia (HP:0001662)1.86929138
122Pheochromocytoma (HP:0002666)1.86678667
123Type II lissencephaly (HP:0007260)1.86615294
124Tubulointerstitial fibrosis (HP:0005576)1.85922347
125Mesomelia (HP:0003027)1.85185106
126Mutism (HP:0002300)1.84850233
127Facial hemangioma (HP:0000329)1.84299556
128Aplasia/Hypoplasia of the lens (HP:0008063)1.84138935
129Specific learning disability (HP:0001328)1.83150819
130Overgrowth (HP:0001548)1.83089860
131Renal duplication (HP:0000075)1.82828085
132Tubular atrophy (HP:0000092)1.82499071
133Generalized hypopigmentation of hair (HP:0011358)1.82032965
134Anencephaly (HP:0002323)1.81639878
135Impaired vibration sensation in the lower limbs (HP:0002166)1.81626571
136Aqueductal stenosis (HP:0002410)1.80862585
137Abnormality of skeletal muscle fiber size (HP:0012084)1.80700871
138Congenital hepatic fibrosis (HP:0002612)1.79116017
139Pointed chin (HP:0000307)1.78921886
140Morphological abnormality of the middle ear (HP:0008609)1.78211859
141Oligodactyly (hands) (HP:0001180)1.77778710
142Postaxial hand polydactyly (HP:0001162)1.77615467
143Dilatation of the ascending aorta (HP:0005111)1.77224499
144Enlarged penis (HP:0000040)1.77035854
145Bicornuate uterus (HP:0000813)1.76785207
146Inability to walk (HP:0002540)1.76481177
147Trigonocephaly (HP:0000243)1.75857683
148Increased connective tissue (HP:0009025)1.75181242
149Narrow nasal bridge (HP:0000446)1.74538884
150Mitral valve prolapse (HP:0001634)1.74535486
151Gaze-evoked nystagmus (HP:0000640)1.73647317
152Bifid tongue (HP:0010297)1.73602190
153Wrist flexion contracture (HP:0001239)1.73525930
154Mildly elevated creatine phosphokinase (HP:0008180)1.73068555
155Dysdiadochokinesis (HP:0002075)1.72990835
156Exotropia (HP:0000577)1.72608934
157Broad foot (HP:0001769)1.72563782
158Birth length less than 3rd percentile (HP:0003561)1.72018368
159Highly arched eyebrow (HP:0002553)1.71852676
160Short tibia (HP:0005736)1.71665085
161Protruding ear (HP:0000411)1.70693803
162Postaxial foot polydactyly (HP:0001830)1.70460526
163Epileptiform EEG discharges (HP:0011182)1.70047713
164Genu recurvatum (HP:0002816)1.70037951
165Urinary bladder sphincter dysfunction (HP:0002839)1.68489800
166Astigmatism (HP:0000483)1.68466583
167Bowel diverticulosis (HP:0005222)1.67266937
168Prominent nasal bridge (HP:0000426)1.66770208
169Hypoplasia of the iris (HP:0007676)1.66128931
170Abnormality of the parietal bone (HP:0002696)1.65763778
171Anxiety (HP:0000739)1.65603152
172Impaired social interactions (HP:0000735)1.65047782
173Abnormal social behavior (HP:0012433)1.65047782
174Upper limb muscle weakness (HP:0003484)1.64515926
175Stereotypic behavior (HP:0000733)1.60874800
176Soft skin (HP:0000977)1.60622073
177Hemiparesis (HP:0001269)1.58396308
178Genetic anticipation (HP:0003743)1.57658091
179Palpebral edema (HP:0100540)1.57544363
180Hyperextensible skin (HP:0000974)1.57311454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.94474380
2EPHA43.85936897
3MARK13.57098806
4MAP3K92.56348777
5NTRK22.41401231
6TNIK2.28285714
7CASK2.22135798
8MAP3K42.16392748
9ACVR1B2.12816926
10TRIM282.08555832
11DDR22.04312079
12SIK22.01800704
13SIK11.94043612
14INSRR1.89515882
15PAK61.86651875
16SIK31.86406645
17MINK11.82213616
18MAP3K121.73734831
19KSR11.72715794
20NTRK11.59259729
21PDGFRA1.55532177
22MAPK131.53451894
23LATS21.53427460
24MAP2K71.50462721
25DAPK21.50051767
26ZAK1.48141535
27ADRBK21.46602895
28TYRO31.42664572
29PIK3CG1.40473691
30FGFR21.39995255
31LATS11.36316658
32EPHB21.35567462
33TAOK31.35067010
34STK38L1.34571194
35CAMKK11.32247529
36MAP2K41.31864867
37CDK51.27458958
38STK391.21249729
39PRKD31.20234362
40PAK31.16783029
41RIPK11.16302009
42CAMK1G1.15851598
43MKNK21.15849860
44KSR21.11954105
45FER1.11697430
46PINK11.11431590
47NUAK11.06466863
48BRSK21.06227642
49MAP4K21.05445085
50MARK21.05178775
51SGK4941.01263965
52SGK2231.01263965
53OXSR11.01157575
54SGK21.00274828
55EPHA30.97352201
56PRKCH0.96218548
57STK110.95705682
58PRPF4B0.93779773
59PRKCG0.93226021
60PHKG10.91880861
61PHKG20.91880861
62CSNK1G20.90891595
63CAMK2A0.90165995
64EIF2AK30.88386871
65PLK20.87002095
66STK30.86102061
67AKT30.85348899
68PLK40.84560100
69ALK0.82948855
70PRKCE0.79892894
71LMTK20.78197882
72CCNB10.77486183
73TRPM70.77394202
74MUSK0.77300445
75FES0.77099015
76CAMK1D0.76075447
77RET0.75629674
78EPHB10.75509412
79WNK40.74953046
80SGK10.73506963
81NEK60.73343234
82SGK30.73236528
83RAF10.71073470
84CAMK10.70973669
85ERBB30.70256622
86FGFR10.68329782
87STK380.66049116
88TAOK10.65864973
89CDK180.63280515
90CSNK1A1L0.62999641
91FGR0.62679150
92PKN10.62572193
93MAP3K70.61159623
94DMPK0.60722519
95BRD40.60684644
96PTK2B0.59771302
97UHMK10.59600826
98IRAK10.59052163
99CDK150.59027330
100MAP3K20.59013755
101RPS6KA20.58775799
102CDK30.58205725
103PIK3CA0.57346144
104CSNK1G10.56705529
105ROCK10.56600662
106DAPK10.56351439
107CDK140.56248824
108NLK0.55955337
109CAMK40.55903452
110BMPR1B0.53311545
111WNK10.52869412
112MAP2K10.52606063
113PDGFRB0.51994536
114PRKG10.51659259
115PNCK0.51342391
116CSNK1G30.51209279
117MAPK100.51183608
118ADRBK10.50293335
119TTK0.50253119
120PRKAA10.50087778
121WNK30.49946910
122FYN0.49905787
123PRKAA20.49259277
124OBSCN0.48848239
125GRK50.48736036
126GRK10.48117845
127CDC42BPA0.47644963
128ERBB20.47136283
129RPS6KA30.46648325
130BCR0.46517412
131EIF2AK20.46483946
132TEC0.44961530
133PTK20.44930115
134DYRK1A0.44558843
135FRK0.43955067
136PRKACB0.43733212
137DYRK20.43496496
138CSNK1D0.43327724
139CAMKK20.42871179
140CHEK20.42775895
141CDK11A0.42741652
142JAK10.42517963
143PRKCZ0.42375274
144CAMK2B0.42239945
145PRKACA0.40119366
146BMPR20.39624133
147TGFBR10.39445524
148MELK0.36923299
149ATM0.36898581

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.96003855
2Olfactory transduction_Homo sapiens_hsa047402.35492729
3Morphine addiction_Homo sapiens_hsa050322.27635103
4Circadian entrainment_Homo sapiens_hsa047132.25442114
5GABAergic synapse_Homo sapiens_hsa047272.23709912
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11114900
7Glutamatergic synapse_Homo sapiens_hsa047242.10334084
8Amphetamine addiction_Homo sapiens_hsa050312.01080399
9Synaptic vesicle cycle_Homo sapiens_hsa047211.98909614
10Butanoate metabolism_Homo sapiens_hsa006501.97427439
11Cocaine addiction_Homo sapiens_hsa050301.93695303
12Axon guidance_Homo sapiens_hsa043601.93376052
13Cholinergic synapse_Homo sapiens_hsa047251.78297233
14Dopaminergic synapse_Homo sapiens_hsa047281.78287623
15Salivary secretion_Homo sapiens_hsa049701.77923519
16ABC transporters_Homo sapiens_hsa020101.77775098
17Long-term potentiation_Homo sapiens_hsa047201.76484508
18Renin secretion_Homo sapiens_hsa049241.75092666
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71229723
20Insulin secretion_Homo sapiens_hsa049111.61841753
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60326551
22Serotonergic synapse_Homo sapiens_hsa047261.60155566
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59352212
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57808518
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54593134
26Gastric acid secretion_Homo sapiens_hsa049711.51827505
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.50033644
28Ether lipid metabolism_Homo sapiens_hsa005651.49375111
29Dilated cardiomyopathy_Homo sapiens_hsa054141.45958501
30Calcium signaling pathway_Homo sapiens_hsa040201.44070291
31Oxytocin signaling pathway_Homo sapiens_hsa049211.43307192
32Taste transduction_Homo sapiens_hsa047421.41251910
33Fanconi anemia pathway_Homo sapiens_hsa034601.40793661
34GnRH signaling pathway_Homo sapiens_hsa049121.38249793
35cAMP signaling pathway_Homo sapiens_hsa040241.34612015
36Gap junction_Homo sapiens_hsa045401.33615392
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32147365
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30378163
39Type II diabetes mellitus_Homo sapiens_hsa049301.29387640
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27487313
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27399635
42Long-term depression_Homo sapiens_hsa047301.25513521
43Selenocompound metabolism_Homo sapiens_hsa004501.25248115
44Basal transcription factors_Homo sapiens_hsa030221.24529705
45Melanogenesis_Homo sapiens_hsa049161.23679697
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23342239
47Glioma_Homo sapiens_hsa052141.16741596
48Circadian rhythm_Homo sapiens_hsa047101.15529998
49Tryptophan metabolism_Homo sapiens_hsa003801.14215653
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13855510
51ECM-receptor interaction_Homo sapiens_hsa045121.13403611
52Basal cell carcinoma_Homo sapiens_hsa052171.08567668
53ErbB signaling pathway_Homo sapiens_hsa040121.08560576
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06740829
55Estrogen signaling pathway_Homo sapiens_hsa049151.06086722
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04994576
57Propanoate metabolism_Homo sapiens_hsa006401.03480059
58Linoleic acid metabolism_Homo sapiens_hsa005911.02546559
59Hedgehog signaling pathway_Homo sapiens_hsa043400.99378908
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98253692
61Dorso-ventral axis formation_Homo sapiens_hsa043200.97276056
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.96579219
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96453063
64Protein digestion and absorption_Homo sapiens_hsa049740.94286860
65Focal adhesion_Homo sapiens_hsa045100.93799314
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91600865
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91147286
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91007926
69Wnt signaling pathway_Homo sapiens_hsa043100.90758013
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.89270663
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88667655
72Rap1 signaling pathway_Homo sapiens_hsa040150.88614391
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86346521
74Ovarian steroidogenesis_Homo sapiens_hsa049130.83711726
75Choline metabolism in cancer_Homo sapiens_hsa052310.80646320
76Homologous recombination_Homo sapiens_hsa034400.80224685
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.76361528
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76031137
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75552596
80Adherens junction_Homo sapiens_hsa045200.75464634
81Hippo signaling pathway_Homo sapiens_hsa043900.75340812
82Endometrial cancer_Homo sapiens_hsa052130.75152583
83Ras signaling pathway_Homo sapiens_hsa040140.74678940
84MAPK signaling pathway_Homo sapiens_hsa040100.72649792
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71072208
86Cardiac muscle contraction_Homo sapiens_hsa042600.70245575
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69757858
88Lysine degradation_Homo sapiens_hsa003100.69396340
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68461672
90Proteoglycans in cancer_Homo sapiens_hsa052050.66922360
91Colorectal cancer_Homo sapiens_hsa052100.66129607
92Thyroid hormone synthesis_Homo sapiens_hsa049180.65480889
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.64824808
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64185415
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63702742
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63221529
97Phototransduction_Homo sapiens_hsa047440.63155206
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61439387
99mTOR signaling pathway_Homo sapiens_hsa041500.61416516
100Pancreatic secretion_Homo sapiens_hsa049720.61223772
101beta-Alanine metabolism_Homo sapiens_hsa004100.60282582
102Amoebiasis_Homo sapiens_hsa051460.59622656
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59256992
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57745105
105Glycerolipid metabolism_Homo sapiens_hsa005610.57195461
106Inositol phosphate metabolism_Homo sapiens_hsa005620.56647147
107Melanoma_Homo sapiens_hsa052180.55534880
108Caffeine metabolism_Homo sapiens_hsa002320.53222526
109TGF-beta signaling pathway_Homo sapiens_hsa043500.52679130
110Alcoholism_Homo sapiens_hsa050340.51999608
111Non-small cell lung cancer_Homo sapiens_hsa052230.51976204
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.50545684
113Glucagon signaling pathway_Homo sapiens_hsa049220.50304048
114Renal cell carcinoma_Homo sapiens_hsa052110.50062500
115Tight junction_Homo sapiens_hsa045300.50014935
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.49678963
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49405506
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49190823
119Oocyte meiosis_Homo sapiens_hsa041140.49019725
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48968306
121Retinol metabolism_Homo sapiens_hsa008300.48394408
122Mineral absorption_Homo sapiens_hsa049780.47652583
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47470453
124One carbon pool by folate_Homo sapiens_hsa006700.47072494
125Bile secretion_Homo sapiens_hsa049760.46950242
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.45852131
127Insulin signaling pathway_Homo sapiens_hsa049100.45587799
128Nitrogen metabolism_Homo sapiens_hsa009100.45500715
129Pathways in cancer_Homo sapiens_hsa052000.44822182
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44405709
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44145437
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43744021
133Fatty acid biosynthesis_Homo sapiens_hsa000610.43063249
134Histidine metabolism_Homo sapiens_hsa003400.42835827

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