DCK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.10762856
2DNA strand elongation involved in DNA replication (GO:0006271)4.98420222
3positive regulation of granulocyte differentiation (GO:0030854)4.80830976
4DNA strand elongation (GO:0022616)4.76557353
5telomere maintenance via semi-conservative replication (GO:0032201)4.66009836
6DNA replication initiation (GO:0006270)4.27265355
7telomere maintenance via recombination (GO:0000722)4.24331315
8protein localization to kinetochore (GO:0034501)4.20788299
9mitotic recombination (GO:0006312)4.14139745
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00729635
11negative regulation of cell killing (GO:0031342)4.00729635
12DNA replication checkpoint (GO:0000076)3.88639035
13regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79009597
14nucleotide-excision repair, DNA gap filling (GO:0006297)3.77023676
15protein localization to chromosome, centromeric region (GO:0071459)3.76288724
16neutrophil activation involved in immune response (GO:0002283)3.67146027
17translesion synthesis (GO:0019985)3.64081183
18positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54076319
19T cell migration (GO:0072678)3.53679628
20positive regulation of gamma-delta T cell activation (GO:0046645)3.49236448
21mitotic chromosome condensation (GO:0007076)3.47074440
22telomere maintenance via telomere lengthening (GO:0010833)3.42924553
23V(D)J recombination (GO:0033151)3.37326162
24kinetochore organization (GO:0051383)3.23272340
25DNA replication-dependent nucleosome assembly (GO:0006335)3.22815908
26DNA replication-dependent nucleosome organization (GO:0034723)3.22815908
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20865062
28postreplication repair (GO:0006301)3.20495836
29regulation of B cell differentiation (GO:0045577)3.18317941
30sister chromatid segregation (GO:0000819)3.17423996
31mitotic sister chromatid segregation (GO:0000070)3.15023040
32regulation of alpha-beta T cell proliferation (GO:0046640)3.06994091
33positive regulation by symbiont of host defense response (GO:0052509)3.06370773
34modulation by symbiont of host defense response (GO:0052031)3.06370773
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06370773
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06370773
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.06370773
38modulation by symbiont of host immune response (GO:0052553)3.06370773
39CENP-A containing nucleosome assembly (GO:0034080)3.03996722
40DNA replication-independent nucleosome assembly (GO:0006336)3.03153157
41DNA replication-independent nucleosome organization (GO:0034724)3.03153157
42negative regulation of phagocytosis (GO:0050765)3.02764983
43mitotic nuclear envelope disassembly (GO:0007077)3.02561925
44megakaryocyte development (GO:0035855)3.02084069
45regulation of DNA endoreduplication (GO:0032875)3.01128103
46neutrophil activation (GO:0042119)2.99472056
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98892143
48chromatin remodeling at centromere (GO:0031055)2.97319613
49immunoglobulin mediated immune response (GO:0016064)2.96392337
50deoxyribose phosphate biosynthetic process (GO:0046385)2.94369262
512-deoxyribonucleotide biosynthetic process (GO:0009265)2.94369262
52mitotic metaphase plate congression (GO:0007080)2.94169725
53negative regulation of T cell apoptotic process (GO:0070233)2.91952828
54telomere organization (GO:0032200)2.91730947
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91300286
56telomere maintenance (GO:0000723)2.90805449
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89377622
58attachment of spindle microtubules to kinetochore (GO:0008608)2.89353502
59dosage compensation (GO:0007549)2.89056452
60positive thymic T cell selection (GO:0045059)2.88110343
61tolerance induction (GO:0002507)2.87333188
62negative regulation of RNA splicing (GO:0033119)2.86913097
63response to interleukin-15 (GO:0070672)2.86795053
64B cell mediated immunity (GO:0019724)2.86229569
65positive T cell selection (GO:0043368)2.85516116
66mitotic sister chromatid cohesion (GO:0007064)2.85494468
67regulation of granulocyte differentiation (GO:0030852)2.84298461
68DNA geometric change (GO:0032392)2.83998108
69DNA duplex unwinding (GO:0032508)2.83953119
70mast cell activation (GO:0045576)2.82178834
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82153954
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82153954
73cellular response to interleukin-15 (GO:0071350)2.81574932
74nuclear pore organization (GO:0006999)2.81011187
75membrane disassembly (GO:0030397)2.80517699
76nuclear envelope disassembly (GO:0051081)2.80517699
77antigen processing and presentation of endogenous antigen (GO:0019883)2.79179530
78protein localization to chromosome (GO:0034502)2.78055391
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77469915
80pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77334639
81negative regulation of T cell mediated immunity (GO:0002710)2.77129420
82nuclear pore complex assembly (GO:0051292)2.76988466
83mismatch repair (GO:0006298)2.75558192
84establishment of chromosome localization (GO:0051303)2.72931058
85deoxyribonucleotide biosynthetic process (GO:0009263)2.72775666
86activated T cell proliferation (GO:0050798)2.72677053
87base-excision repair (GO:0006284)2.72588593
88DNA synthesis involved in DNA repair (GO:0000731)2.70682814
89T cell selection (GO:0045058)2.70516235
90DNA double-strand break processing (GO:0000729)2.70247454
91DNA topological change (GO:0006265)2.69323755
92regulation of regulatory T cell differentiation (GO:0045589)2.69163363
93mast cell degranulation (GO:0043303)2.69047349
94mast cell activation involved in immune response (GO:0002279)2.69047349
95antigen receptor-mediated signaling pathway (GO:0050851)2.69007980
96regulation of sister chromatid cohesion (GO:0007063)2.68979392
97kinetochore assembly (GO:0051382)2.66056267
98B cell proliferation (GO:0042100)2.64990932
99Peyers patch development (GO:0048541)2.64640837
100mucosal-associated lymphoid tissue development (GO:0048537)2.64640837
101somatic cell DNA recombination (GO:0016444)2.63921208
102somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.63921208
103positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.63744332
104hepatocyte apoptotic process (GO:0097284)2.63086403
105ATP-dependent chromatin remodeling (GO:0043044)2.62515951
106chromatin assembly or disassembly (GO:0006333)2.62393677
107somatic diversification of immune receptors (GO:0002200)2.61998559
108DNA ligation (GO:0006266)2.61825949
109regulation of gamma-delta T cell differentiation (GO:0045586)2.61508517
110regulation of gamma-delta T cell activation (GO:0046643)2.60211646
111positive regulation of chromosome segregation (GO:0051984)2.59947002
112intra-S DNA damage checkpoint (GO:0031573)2.59204633
113positive regulation of T cell cytokine production (GO:0002726)2.58695056
114T cell homeostasis (GO:0043029)2.58496563
115negative T cell selection (GO:0043383)2.58438331
116positive regulation of interferon-alpha production (GO:0032727)2.58263392
117chromosome segregation (GO:0007059)2.57792927
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57289571
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56894310
120dendritic cell migration (GO:0036336)2.56891640
121myeloid cell development (GO:0061515)2.56784025
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56681336
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.56681336
124negative regulation of thymocyte apoptotic process (GO:0070244)2.56456365
125positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.55087323
126meiotic chromosome segregation (GO:0045132)2.54895883
127granulocyte activation (GO:0036230)2.54732991
128regulation of histone H3-K9 methylation (GO:0051570)2.54478149
129leukocyte aggregation (GO:0070486)2.53968589
130regulation of B cell receptor signaling pathway (GO:0050855)2.52556457
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.52030500
1323-UTR-mediated mRNA stabilization (GO:0070935)2.51870239
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.51636063
134positive regulation of mast cell activation (GO:0033005)2.51600243
135positive regulation of alpha-beta T cell activation (GO:0046635)2.51567056
136regulation of isotype switching to IgG isotypes (GO:0048302)2.51501850
137dendritic cell chemotaxis (GO:0002407)2.51022570
138regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50345085
139metaphase plate congression (GO:0051310)2.50342010
140negative regulation of mRNA processing (GO:0050686)2.49222173
141leukocyte degranulation (GO:0043299)2.49099709
142B cell receptor signaling pathway (GO:0050853)2.48958645
143establishment of integrated proviral latency (GO:0075713)2.48856987
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48476781
145histone exchange (GO:0043486)2.48331280
146rRNA catabolic process (GO:0016075)2.45929480
147positive regulation of B cell differentiation (GO:0045579)2.45919822
148thymic T cell selection (GO:0045061)2.45396659
149regulation of interferon-alpha production (GO:0032647)2.45000961
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44809131
151negative thymic T cell selection (GO:0045060)2.44048075
152DNA conformation change (GO:0071103)2.42368775
153protoporphyrinogen IX metabolic process (GO:0046501)2.42349831
154negative regulation of T-helper cell differentiation (GO:0045623)2.42292270
155negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.42292270
156regulation of protein heterodimerization activity (GO:0043497)2.42268303
157mitochondrial calcium ion transport (GO:0006851)2.42060330
158B cell activation (GO:0042113)2.41465189
159natural killer cell mediated cytotoxicity (GO:0042267)2.41220160
160defense response to protozoan (GO:0042832)2.38757264
161myeloid cell activation involved in immune response (GO:0002275)2.37690478
162positive regulation of interleukin-2 production (GO:0032743)2.36141641
163lymphocyte proliferation (GO:0046651)2.35456392
164mitotic G2 DNA damage checkpoint (GO:0007095)2.35257512
165actin nucleation (GO:0045010)2.34584145
166regulation of fibroblast apoptotic process (GO:2000269)2.32772277
167G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.32462255
168lymphocyte homeostasis (GO:0002260)2.32051596
169centriole replication (GO:0007099)2.31178039
170positive regulation of mast cell degranulation (GO:0043306)2.30763935
171positive regulation of mast cell activation involved in immune response (GO:0033008)2.30763935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.04775724
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88761385
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.57626543
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13816671
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10359374
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.82227276
7MYC_22102868_ChIP-Seq_BL_Human2.69133921
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.67486377
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.46711494
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45471732
11GATA1_22025678_ChIP-Seq_K562_Human2.30607359
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25577835
13RUNX_20019798_ChIP-Seq_JUKART_Human2.19462166
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08683077
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.07395394
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02559717
17E2F7_22180533_ChIP-Seq_HELA_Human11.0961654
18VDR_21846776_ChIP-Seq_THP-1_Human1.98782749
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94516041
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92715179
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88441584
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85632913
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.84564289
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80129107
25IGF1R_20145208_ChIP-Seq_DFB_Human1.79521500
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75159448
27XRN2_22483619_ChIP-Seq_HELA_Human1.74772869
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74720368
29GATA3_27048872_Chip-Seq_THYMUS_Human1.74110575
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73349209
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72954975
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71531097
33CIITA_25753668_ChIP-Seq_RAJI_Human1.71458941
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.66269868
35* AR_21909140_ChIP-Seq_LNCAP_Human1.66009516
36MYB_26560356_Chip-Seq_TH2_Human1.65112464
37VDR_23849224_ChIP-Seq_CD4+_Human1.64260063
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63096799
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.59466928
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.59413596
41SPI1_23547873_ChIP-Seq_NB4_Human1.59356711
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58494532
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58314925
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57984298
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56700199
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55511996
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55395993
48FOXP3_21729870_ChIP-Seq_TREG_Human1.55035689
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52885783
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52515579
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52109281
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.51882956
53MAF_26560356_Chip-Seq_TH1_Human1.50628155
54GATA3_26560356_Chip-Seq_TH2_Human1.50313738
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.50308453
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47235080
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47173668
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46027084
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45553820
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.45387437
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43458452
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41047349
63UTX_26944678_Chip-Seq_JUKART_Human1.39981351
64* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39634297
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38776245
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37820941
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35197876
68ELK1_19687146_ChIP-ChIP_HELA_Human1.33844573
69DCP1A_22483619_ChIP-Seq_HELA_Human1.33826298
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33310780
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32694981
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32106671
73MYB_26560356_Chip-Seq_TH1_Human1.32041209
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31611538
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30127194
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.29560020
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28636495
78IRF1_19129219_ChIP-ChIP_H3396_Human1.26763898
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26411238
80GABP_19822575_ChIP-Seq_HepG2_Human1.25913480
81SCL_19346495_ChIP-Seq_HPC-7_Human1.24938473
82* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24866159
83TTF2_22483619_ChIP-Seq_HELA_Human1.24849263
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24045709
85* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23493306
86VDR_24763502_ChIP-Seq_THP-1_Human1.23344445
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.22723679
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19049418
89* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17029728
90EWS_26573619_Chip-Seq_HEK293_Human1.16643176
91* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16485223
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15028309
93KDM5A_27292631_Chip-Seq_BREAST_Human1.14026030
94TFEB_21752829_ChIP-Seq_HELA_Human1.12963861
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12961013
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12662839
97TAF15_26573619_Chip-Seq_HEK293_Human1.10742719
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10640313
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09593284
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08316409
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07147863
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05610521
103TCF7_22412390_ChIP-Seq_EML_Mouse1.03485885
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03376243
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03040068
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01616882
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.00930567
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00547044
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00008811
110SALL4_22934838_ChIP-ChIP_CD34+_Human0.99685306
111MAF_26560356_Chip-Seq_TH2_Human0.99495609
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98035091
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96669129
114* GATA3_26560356_Chip-Seq_TH1_Human0.96193243
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95809988
116FUS_26573619_Chip-Seq_HEK293_Human0.95000181
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94679528
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93577440
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92740598
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92652365
121MYC_18940864_ChIP-ChIP_HL60_Human0.92377805
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92256051
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91142759
124BP1_19119308_ChIP-ChIP_Hs578T_Human0.90387616
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89868150
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89669739
127SPI1_23127762_ChIP-Seq_K562_Human0.89024569
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88777796
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88221773
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86983590
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83809986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.95233891
2MP0003693_abnormal_embryo_hatching3.28820364
3MP0008057_abnormal_DNA_replication3.23536753
4MP0001835_abnormal_antigen_presentation3.18025480
5MP0003111_abnormal_nucleus_morphology3.15897988
6MP0003077_abnormal_cell_cycle2.98498671
7MP0002009_preneoplasia2.83417206
8MP0004957_abnormal_blastocyst_morpholog2.57820644
9MP0005671_abnormal_response_to2.56171282
10MP0009785_altered_susceptibility_to2.51706287
11MP0000685_abnormal_immune_system2.48366250
12MP0001800_abnormal_humoral_immune2.48239368
13MP0002396_abnormal_hematopoietic_system2.41589145
14MP0003436_decreased_susceptibility_to2.37759432
15* MP0002398_abnormal_bone_marrow2.30879241
16MP0005075_abnormal_melanosome_morpholog2.27815552
17MP0008058_abnormal_DNA_repair2.26350473
18MP0002452_abnormal_antigen_presenting2.23506362
19MP0003303_peritoneal_inflammation2.18696716
20MP0005000_abnormal_immune_tolerance2.18533779
21MP0004147_increased_porphyrin_level2.18016884
22MP0009278_abnormal_bone_marrow2.13229728
23MP0004808_abnormal_hematopoietic_stem2.12371866
24MP0005076_abnormal_cell_differentiation2.10190373
25MP0010307_abnormal_tumor_latency2.08357724
26MP0002420_abnormal_adaptive_immunity2.05621147
27MP0001819_abnormal_immune_cell2.05570792
28MP0003763_abnormal_thymus_physiology2.04644085
29MP0001790_abnormal_immune_system2.04275035
30MP0005387_immune_system_phenotype2.04275035
31MP0008007_abnormal_cellular_replicative2.03360726
32MP0002723_abnormal_immune_serum2.01125957
33MP0005025_abnormal_response_to1.97926905
34* MP0000703_abnormal_thymus_morphology1.91206803
35MP0000490_abnormal_crypts_of1.90426272
36* MP0000716_abnormal_immune_system1.89325720
37* MP0002722_abnormal_immune_system1.87120065
38* MP0000689_abnormal_spleen_morphology1.85827630
39MP0010352_gastrointestinal_tract_polyps1.83916126
40MP0009333_abnormal_splenocyte_physiolog1.82990508
41MP0002148_abnormal_hypersensitivity_rea1.82972792
42MP0003787_abnormal_imprinting1.81417049
43MP0000350_abnormal_cell_proliferation1.80361263
44MP0002419_abnormal_innate_immunity1.76109073
45* MP0002429_abnormal_blood_cell1.73561804
46MP0001545_abnormal_hematopoietic_system1.73252971
47MP0005397_hematopoietic_system_phenotyp1.73252971
48MP0006082_CNS_inflammation1.69500760
49MP0002166_altered_tumor_susceptibility1.62242294
50MP0002405_respiratory_system_inflammati1.57436405
51MP0002019_abnormal_tumor_incidence1.56374802
52MP0002006_tumorigenesis1.52852554
53MP0004947_skin_inflammation1.48198192
54MP0008932_abnormal_embryonic_tissue1.47419964
55MP0001730_embryonic_growth_arrest1.45157091
56MP0001986_abnormal_taste_sensitivity1.45041168
57MP0010155_abnormal_intestine_physiology1.38808567
58MP0006054_spinal_hemorrhage1.35259217
59MP0002877_abnormal_melanocyte_morpholog1.34409810
60MP0000313_abnormal_cell_death1.34306913
61MP0005645_abnormal_hypothalamus_physiol1.30348056
62MP0000858_altered_metastatic_potential1.28634988
63MP0003448_altered_tumor_morphology1.25741522
64MP0002163_abnormal_gland_morphology1.21002907
65MP0005464_abnormal_platelet_physiology1.20040299
66MP0001853_heart_inflammation1.16738609
67MP0001845_abnormal_inflammatory_respons1.16608795
68MP0003866_abnormal_defecation1.13079680
69MP0008877_abnormal_DNA_methylation1.08277918
70MP0003656_abnormal_erythrocyte_physiolo1.06651071
71MP0001697_abnormal_embryo_size1.05021256
72MP0005084_abnormal_gallbladder_morpholo1.04518244
73MP0003121_genomic_imprinting1.04127173
74MP0005380_embryogenesis_phenotype0.98958607
75MP0001672_abnormal_embryogenesis/_devel0.98958607
76MP0002080_prenatal_lethality0.98694131
77MP0003984_embryonic_growth_retardation0.98608261
78MP0001533_abnormal_skeleton_physiology0.97130302
79MP0002088_abnormal_embryonic_growth/wei0.95728712
80MP0003123_paternal_imprinting0.95231944
81MP0003300_gastrointestinal_ulcer0.93666750
82MP0005174_abnormal_tail_pigmentation0.91451998
83MP0008995_early_reproductive_senescence0.89076366
84MP0009697_abnormal_copulation0.88317628
85MP0004197_abnormal_fetal_growth/weight/0.86571326
86MP0002102_abnormal_ear_morphology0.85623187
87MP0002085_abnormal_embryonic_tissue0.84831065
88MP0000569_abnormal_digit_pigmentation0.84764702
89MP0001915_intracranial_hemorrhage0.84705098
90MP0008260_abnormal_autophagy0.83690642
91MP0002095_abnormal_skin_pigmentation0.82753701
92MP0002086_abnormal_extraembryonic_tissu0.81912701
93MP0009763_increased_sensitivity_to0.81626016
94MP0001188_hyperpigmentation0.80576815
95MP0001851_eye_inflammation0.78095008
96MP0003183_abnormal_peptide_metabolism0.77163768
97MP0003172_abnormal_lysosome_physiology0.76343298
98MP0005621_abnormal_cell_physiology0.75664174
99MP0003724_increased_susceptibility_to0.75250294
100MP0002132_abnormal_respiratory_system0.74802106
101MP0002933_joint_inflammation0.73748205
102MP0008469_abnormal_protein_level0.73483292
103MP0000465_gastrointestinal_hemorrhage0.72674235
104MP0000015_abnormal_ear_pigmentation0.72256357
105MP0009053_abnormal_anal_canal0.71151782
106MP0002693_abnormal_pancreas_physiology0.70139685
107MP0004510_myositis0.70099769
108MP0002653_abnormal_ependyma_morphology0.70092827
109MP0006072_abnormal_retinal_apoptosis0.70021250
110MP0001529_abnormal_vocalization0.69466783
111MP0000372_irregular_coat_pigmentation0.69312594
112MP0003786_premature_aging0.67231028
113MP0005384_cellular_phenotype0.66987293
114MP0005379_endocrine/exocrine_gland_phen0.66447222
115MP0004381_abnormal_hair_follicle0.66039890
116MP0009765_abnormal_xenobiotic_induced0.66018913
117MP0002084_abnormal_developmental_patter0.65265777
118MP0001873_stomach_inflammation0.64297006
119MP0005310_abnormal_salivary_gland0.62914424
120MP0002083_premature_death0.62376365
121MP0001293_anophthalmia0.61803993
122MP0000343_altered_response_to0.61483440
123MP0001929_abnormal_gametogenesis0.61471937
124MP0009764_decreased_sensitivity_to0.58818413
125MP0006036_abnormal_mitochondrial_physio0.58647122
126MP0003221_abnormal_cardiomyocyte_apopto0.57859495
127MP0002277_abnormal_respiratory_mucosa0.56915235
128MP0006035_abnormal_mitochondrial_morpho0.56302345
129MP0003943_abnormal_hepatobiliary_system0.54659042

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.19875245
2Abnormality of B cell number (HP:0010975)4.19875245
3Recurrent viral infections (HP:0004429)4.06881174
4T lymphocytopenia (HP:0005403)3.75205910
5Thyroiditis (HP:0100646)3.74962850
6Severe combined immunodeficiency (HP:0004430)3.68403110
7Abnormality of T cell number (HP:0011839)3.66247477
8Recurrent abscess formation (HP:0002722)3.57997395
9Combined immunodeficiency (HP:0005387)3.57808273
10Cellulitis (HP:0100658)3.55592819
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.45240028
12Birth length less than 3rd percentile (HP:0003561)3.38717057
13Panhypogammaglobulinemia (HP:0003139)3.35395733
14Prolonged bleeding time (HP:0003010)3.29399941
15Recurrent fungal infections (HP:0002841)3.25192043
16Stomatitis (HP:0010280)3.23117958
17Autoimmune hemolytic anemia (HP:0001890)3.22612742
18Encephalitis (HP:0002383)3.16615816
19Agammaglobulinemia (HP:0004432)3.13589472
20Recurrent bacterial skin infections (HP:0005406)3.07679115
21Recurrent bronchitis (HP:0002837)3.04124204
22Elevated erythrocyte sedimentation rate (HP:0003565)3.01860904
23Abnormality of T cells (HP:0002843)3.00333972
24Eczematoid dermatitis (HP:0000976)3.00020676
25IgG deficiency (HP:0004315)2.91070621
26Meningitis (HP:0001287)2.90306340
27Mediastinal lymphadenopathy (HP:0100721)2.89834673
28Agnosia (HP:0010524)2.86869637
29Eosinophilia (HP:0001880)2.84475990
30Volvulus (HP:0002580)2.82365637
31IgM deficiency (HP:0002850)2.76579762
32Chronic otitis media (HP:0000389)2.74151702
33Chromsome breakage (HP:0040012)2.72026000
34Lymphoma (HP:0002665)2.71909380
35Abnormality of chromosome stability (HP:0003220)2.67903229
36Hypoplasia of the thymus (HP:0000778)2.64987787
37Papilloma (HP:0012740)2.62771352
38Verrucae (HP:0200043)2.62771352
39Autoimmune thrombocytopenia (HP:0001973)2.59228134
40Granulocytopenia (HP:0001913)2.55677283
41Abnormality of the prostate (HP:0008775)2.54173812
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53597172
43Patellar aplasia (HP:0006443)2.52855410
44Constricted visual fields (HP:0001133)2.52392673
45Abnormality of the anterior horn cell (HP:0006802)2.51128723
46Degeneration of anterior horn cells (HP:0002398)2.51128723
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.50256625
48Abnormal number of incisors (HP:0011064)2.49124756
49Abnormality of eosinophils (HP:0001879)2.47110552
50Papilledema (HP:0001085)2.43937893
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.43203759
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.39859625
53Chronic obstructive pulmonary disease (HP:0006510)2.37674266
54Obstructive lung disease (HP:0006536)2.37674266
55Myositis (HP:0100614)2.35594587
56Lymphopenia (HP:0001888)2.34163459
57Leukocytosis (HP:0001974)2.33380395
58Increased nuchal translucency (HP:0010880)2.32971350
59Aplasia/Hypoplasia of the patella (HP:0006498)2.32954083
60Microcytic anemia (HP:0001935)2.32508512
61Recurrent pneumonia (HP:0006532)2.30459930
62Epistaxis (HP:0000421)2.28361100
63Hypochromic microcytic anemia (HP:0004840)2.26825846
64Abnormal platelet volume (HP:0011876)2.25485067
65Abnormality of the ileum (HP:0001549)2.24073144
66Recurrent gram-negative bacterial infections (HP:0005420)2.21974105
67Gingival bleeding (HP:0000225)2.19499072
68Stomach cancer (HP:0012126)2.18885481
69Osteomyelitis (HP:0002754)2.18590375
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18557843
71Short 4th metacarpal (HP:0010044)2.18557843
72Poikilocytosis (HP:0004447)2.18365398
73Aplasia/Hypoplasia of the thymus (HP:0010515)2.16496531
74Meckel diverticulum (HP:0002245)2.15397075
75Spontaneous hematomas (HP:0007420)2.14697866
76Vasculitis (HP:0002633)2.14574108
77Abnormality of T cell physiology (HP:0011840)2.14476066
78Duodenal stenosis (HP:0100867)2.12563054
79Small intestinal stenosis (HP:0012848)2.12563054
80Reticulocytopenia (HP:0001896)2.12380967
81Recurrent lower respiratory tract infections (HP:0002783)2.12325913
82Abnormality of the fingertips (HP:0001211)2.10094528
83Abnormality of macrophages (HP:0004311)2.09821812
84Sepsis (HP:0100806)2.09157540
85Inflammation of the large intestine (HP:0002037)2.08557733
86Medulloblastoma (HP:0002885)2.08377441
87Ectopic kidney (HP:0000086)2.07217293
88Chronic mucocutaneous candidiasis (HP:0002728)2.04621095
89Recurrent cutaneous fungal infections (HP:0011370)2.04621095
90Myelodysplasia (HP:0002863)2.04343486
91Papillary thyroid carcinoma (HP:0002895)2.03835880
92Acute hepatic failure (HP:0006554)2.03077198
93Proximal placement of thumb (HP:0009623)2.02363005
94Amyotrophic lateral sclerosis (HP:0007354)2.02238097
95Gastrointestinal inflammation (HP:0004386)2.02018177
96Increased mean platelet volume (HP:0011877)2.01931762
97Cutis marmorata (HP:0000965)2.01329972
98Neutropenia (HP:0001875)2.01129594
99Bone marrow hypocellularity (HP:0005528)2.00236451
100Cellular immunodeficiency (HP:0005374)1.99978049
101Cleft eyelid (HP:0000625)1.99808464
102Recurrent skin infections (HP:0001581)1.99745367
103Abnormality of the preputium (HP:0100587)1.98149844
104Hypoproteinemia (HP:0003075)1.98108448
105Petechiae (HP:0000967)1.96193262
106Poor head control (HP:0002421)1.95960141
107Thyroid carcinoma (HP:0002890)1.95255322
108Cutaneous melanoma (HP:0012056)1.94693400
109Basal cell carcinoma (HP:0002671)1.94664637
110Abnormality of the intervertebral disk (HP:0005108)1.94600340
111Retrobulbar optic neuritis (HP:0100654)1.94166646
112Optic neuritis (HP:0100653)1.94166646
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.91848785
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91848785
115Acute lymphatic leukemia (HP:0006721)1.90326380
116Amaurosis fugax (HP:0100576)1.89747382
117Clubbing of toes (HP:0100760)1.89340297
118Deviation of the thumb (HP:0009603)1.88739225
119Small epiphyses (HP:0010585)1.87271326
120Leukopenia (HP:0001882)1.87042444
121Basal ganglia calcification (HP:0002135)1.86368831
122Keratoconjunctivitis sicca (HP:0001097)1.85002273
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.83059747
124Increased IgM level (HP:0003496)1.82534886
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82427982
126Absent epiphyses (HP:0010577)1.82427982
127Toxemia of pregnancy (HP:0100603)1.81597523
128Long eyelashes (HP:0000527)1.81133521
129High pitched voice (HP:0001620)1.80775780
130Chronic diarrhea (HP:0002028)1.79407156
131Keratoconjunctivitis (HP:0001096)1.78283679
132Abnormality of the carotid arteries (HP:0005344)1.77478466
133Porencephaly (HP:0002132)1.76295143
134Thrombocytosis (HP:0001894)1.76248882
135IgA deficiency (HP:0002720)1.75897931
136Urticaria (HP:0001025)1.75491724
137Chest pain (HP:0100749)1.74540303
138Viral hepatitis (HP:0006562)1.73997478
139Renal cortical cysts (HP:0000803)1.67713299
140Cutaneous photosensitivity (HP:0000992)1.64916484
141Prostate neoplasm (HP:0100787)1.62178574
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60329239
143Abnormality of the thymus (HP:0000777)1.59987238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.92500225
2MAP3K103.66049512
3FES2.87697893
4MAP4K12.85532977
5WEE12.78474880
6BUB12.50701131
7PASK2.39144742
8NEK22.39021294
9SIK32.19764573
10TAOK32.16741371
11TESK22.09112138
12STK102.03367935
13RPS6KA41.90388911
14BLK1.86553069
15TRIM281.85813513
16CDK121.84763873
17CAMKK21.84287973
18ACVR1B1.82142145
19EIF2AK11.76969973
20ERBB31.74266621
21ERN11.71845547
22BCR1.69462332
23TYK21.67144884
24BMPR21.66982800
25STK41.65234070
26BRSK11.61943813
27CCNB11.60658434
28ATR1.58381252
29BRSK21.55278623
30IRAK41.54435585
31TLK11.50287083
32CDK191.44811008
33PRPF4B1.40838063
34GRK61.40739064
35CLK11.37804638
36TBK11.35598349
37SYK1.33594362
38NEK11.32209263
39SRPK11.31077732
40MAP2K71.30972039
41EEF2K1.30912305
42CDK41.30394325
43MAP3K41.29591348
44DYRK31.28954868
45MAP4K21.22809565
46BTK1.21911941
47JAK31.21804275
48PBK1.19911424
49ZAP701.19792950
50PLK11.17712192
51TXK1.17020886
52VRK11.16074643
53AURKB1.12491272
54PIM11.11324148
55KSR11.10851666
56NME21.07508709
57MAP3K81.06798742
58CSF1R1.04783051
59CDK71.04046746
60NLK1.03455458
61ZAK1.03247458
62PKN21.02629868
63SCYL20.99279937
64KIT0.97312297
65PLK40.96131715
66EIF2AK30.95995022
67LRRK20.95180607
68TTK0.95040215
69IKBKE0.92827223
70MAP3K130.91370202
71TESK10.89437624
72CHEK20.89184997
73LYN0.88485732
74CDK30.87525505
75YES10.85761601
76CHEK10.85651568
77FGR0.85171962
78MKNK10.84899639
79MAP3K140.83739420
80PLK30.82441967
81CDK60.82429318
82JAK10.82074253
83TGFBR10.81126855
84BRD40.77005826
85JAK20.75902147
86ITK0.74882667
87PAK40.74870509
88HCK0.72569681
89RIPK40.72558488
90MELK0.70801812
91RPS6KB20.70189104
92UHMK10.68512802
93PRKCQ0.68349797
94FGFR30.68084089
95LCK0.67445815
96TAOK20.67162947
97IKBKB0.65768304
98FGFR40.65359118
99TSSK60.62999391
100CDK20.60689454
101NUAK10.59653879
102MAP3K50.59523020
103TNK20.59116612
104MAPK110.58515234
105ATM0.56723711
106CSK0.56549148
107FLT30.55936420
108RPS6KA50.55410900
109PIK3CG0.55321327
110MAPK130.55161283
111MARK30.54063567
112CAMKK10.54036815
113AURKA0.53860451
114MAP3K110.53286543
115TRIB30.52069329
116DYRK1B0.51931905
117CHUK0.50867261
118EIF2AK20.49060770
119PIM20.48544759
120NEK90.48463757
121STK30.48053984
122MINK10.47789173
123CDK140.46808014
124MATK0.46648612
125TEC0.46243125
126EGFR0.45381036
127SIK20.43175481
128ALK0.43057693
129MST40.42141431
130PLK20.41468314
131MAP2K40.41227181
132CDK10.40891408
133FYN0.39444399
134CSNK1G30.38741373
135MAP2K30.38345454
136RAF10.37151018
137FRK0.36888313

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70289411
2Mismatch repair_Homo sapiens_hsa034303.49472982
3Base excision repair_Homo sapiens_hsa034102.93644634
4Primary immunodeficiency_Homo sapiens_hsa053402.76399042
5Cell cycle_Homo sapiens_hsa041102.59756014
6Spliceosome_Homo sapiens_hsa030402.44523554
7Homologous recombination_Homo sapiens_hsa034402.41572346
8Non-homologous end-joining_Homo sapiens_hsa034502.35349602
9Nucleotide excision repair_Homo sapiens_hsa034201.97964658
10Proteasome_Homo sapiens_hsa030501.79365827
11Leishmaniasis_Homo sapiens_hsa051401.79215320
12RNA transport_Homo sapiens_hsa030131.78142354
13Herpes simplex infection_Homo sapiens_hsa051681.72434085
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.65903285
15Measles_Homo sapiens_hsa051621.64954022
16Fanconi anemia pathway_Homo sapiens_hsa034601.64290848
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62809452
18Antigen processing and presentation_Homo sapiens_hsa046121.62796470
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.57213063
20p53 signaling pathway_Homo sapiens_hsa041151.54962422
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51474217
22B cell receptor signaling pathway_Homo sapiens_hsa046621.48712247
23One carbon pool by folate_Homo sapiens_hsa006701.41580725
24* Pyrimidine metabolism_Homo sapiens_hsa002401.40702094
25Legionellosis_Homo sapiens_hsa051341.39251341
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37635771
27Epstein-Barr virus infection_Homo sapiens_hsa051691.32333330
28mRNA surveillance pathway_Homo sapiens_hsa030151.29970132
29Systemic lupus erythematosus_Homo sapiens_hsa053221.27824996
30Hepatitis B_Homo sapiens_hsa051611.27731683
31Viral carcinogenesis_Homo sapiens_hsa052031.27663913
32Regulation of autophagy_Homo sapiens_hsa041401.26681905
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24335080
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23719224
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22463837
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21912501
37Influenza A_Homo sapiens_hsa051641.20722847
38Allograft rejection_Homo sapiens_hsa053301.19210055
39Ribosome_Homo sapiens_hsa030101.17780235
40Graft-versus-host disease_Homo sapiens_hsa053321.17642409
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17292978
42Osteoclast differentiation_Homo sapiens_hsa043801.16952983
43Shigellosis_Homo sapiens_hsa051311.16246248
44Platelet activation_Homo sapiens_hsa046111.14801868
45RNA polymerase_Homo sapiens_hsa030201.14313829
46HTLV-I infection_Homo sapiens_hsa051661.12971747
47Apoptosis_Homo sapiens_hsa042101.12266110
48Chronic myeloid leukemia_Homo sapiens_hsa052201.11215745
49Viral myocarditis_Homo sapiens_hsa054161.07842804
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05483919
51RNA degradation_Homo sapiens_hsa030181.04966951
52Hematopoietic cell lineage_Homo sapiens_hsa046401.04159362
53T cell receptor signaling pathway_Homo sapiens_hsa046601.03875558
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03343537
55MicroRNAs in cancer_Homo sapiens_hsa052060.94183185
56Pertussis_Homo sapiens_hsa051330.93789388
57Colorectal cancer_Homo sapiens_hsa052100.93164526
58Tuberculosis_Homo sapiens_hsa051520.92292174
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91651759
60Pancreatic cancer_Homo sapiens_hsa052120.87572248
61TNF signaling pathway_Homo sapiens_hsa046680.85045256
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84789605
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84121854
64Toxoplasmosis_Homo sapiens_hsa051450.83447510
65Asthma_Homo sapiens_hsa053100.82427551
66Rheumatoid arthritis_Homo sapiens_hsa053230.82343997
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81949444
68Basal transcription factors_Homo sapiens_hsa030220.81552729
69Small cell lung cancer_Homo sapiens_hsa052220.80345046
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78839550
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77183324
72Notch signaling pathway_Homo sapiens_hsa043300.75310137
73Protein export_Homo sapiens_hsa030600.75232042
74Non-small cell lung cancer_Homo sapiens_hsa052230.74049285
75Chemokine signaling pathway_Homo sapiens_hsa040620.73717545
76Malaria_Homo sapiens_hsa051440.71447581
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70055902
78Acute myeloid leukemia_Homo sapiens_hsa052210.69943837
79Salmonella infection_Homo sapiens_hsa051320.68876209
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.68200098
81Oocyte meiosis_Homo sapiens_hsa041140.67655013
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.64267226
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63769499
84Type I diabetes mellitus_Homo sapiens_hsa049400.63359956
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.59847216
86Phototransduction_Homo sapiens_hsa047440.56040517
87Staphylococcus aureus infection_Homo sapiens_hsa051500.55202138
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54312414
89Renal cell carcinoma_Homo sapiens_hsa052110.53103972
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52586033
91Alcoholism_Homo sapiens_hsa050340.50850911
92* Purine metabolism_Homo sapiens_hsa002300.49369195
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47556719
94African trypanosomiasis_Homo sapiens_hsa051430.47139285
95Hepatitis C_Homo sapiens_hsa051600.45664817
96Thyroid cancer_Homo sapiens_hsa052160.43566501
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.43007126
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42933143
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42841239
100Basal cell carcinoma_Homo sapiens_hsa052170.42218225
101Autoimmune thyroid disease_Homo sapiens_hsa053200.41720124
102HIF-1 signaling pathway_Homo sapiens_hsa040660.41626009
103Pentose phosphate pathway_Homo sapiens_hsa000300.40512516
104FoxO signaling pathway_Homo sapiens_hsa040680.39968354
105Long-term depression_Homo sapiens_hsa047300.39597443
106Prostate cancer_Homo sapiens_hsa052150.39542326
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38632273
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38178347
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36425870
110Pathways in cancer_Homo sapiens_hsa052000.36358874
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36302387
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35625085
113Phagosome_Homo sapiens_hsa041450.34535708
114VEGF signaling pathway_Homo sapiens_hsa043700.34409583
115Endometrial cancer_Homo sapiens_hsa052130.34248860
116Bladder cancer_Homo sapiens_hsa052190.34094452
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32428014
118Olfactory transduction_Homo sapiens_hsa047400.31902928
119Prolactin signaling pathway_Homo sapiens_hsa049170.28514475
120Endocytosis_Homo sapiens_hsa041440.24111542

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