DCLK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.94615225
2vocalization behavior (GO:0071625)5.66678732
3locomotory exploration behavior (GO:0035641)5.65443655
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.64553949
5synaptic vesicle maturation (GO:0016188)5.53117419
6synaptic vesicle exocytosis (GO:0016079)5.41092729
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39430648
8glutamate secretion (GO:0014047)5.28359638
9protein localization to synapse (GO:0035418)5.13078282
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09695212
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.98350934
12regulation of glutamate receptor signaling pathway (GO:1900449)4.97396034
13neuron cell-cell adhesion (GO:0007158)4.91359533
14regulation of synaptic vesicle exocytosis (GO:2000300)4.85607145
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.81408614
16exploration behavior (GO:0035640)4.59436989
17layer formation in cerebral cortex (GO:0021819)4.57507901
18glutamate receptor signaling pathway (GO:0007215)4.52359584
19neurotransmitter-gated ion channel clustering (GO:0072578)4.50412432
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.41302422
21synaptic transmission, glutamatergic (GO:0035249)4.40169171
22regulation of synaptic vesicle transport (GO:1902803)4.34802519
23regulation of synapse structural plasticity (GO:0051823)4.33160115
24regulation of neuronal synaptic plasticity (GO:0048168)4.31821940
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.26920298
26dendritic spine morphogenesis (GO:0060997)4.24114419
27positive regulation of synapse maturation (GO:0090129)4.21518094
28neurotransmitter secretion (GO:0007269)4.14132397
29neuron-neuron synaptic transmission (GO:0007270)4.10363315
30gamma-aminobutyric acid transport (GO:0015812)4.08573893
31neuronal action potential propagation (GO:0019227)4.03420899
32neuron recognition (GO:0008038)3.98768210
33proline transport (GO:0015824)3.93196137
34postsynaptic membrane organization (GO:0001941)3.90547651
35establishment of mitochondrion localization (GO:0051654)3.86853408
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86592972
37long-term memory (GO:0007616)3.86128153
38nucleobase catabolic process (GO:0046113)3.81520219
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.80803320
40axonal fasciculation (GO:0007413)3.79653664
41positive regulation of membrane potential (GO:0045838)3.72369260
42regulation of dendritic spine morphogenesis (GO:0061001)3.71657959
43regulation of postsynaptic membrane potential (GO:0060078)3.67743598
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62529507
45regulation of synaptic plasticity (GO:0048167)3.62409455
46neuronal ion channel clustering (GO:0045161)3.61179419
47presynaptic membrane assembly (GO:0097105)3.55529549
48* dendrite morphogenesis (GO:0048813)3.50772440
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.46846251
50transmission of nerve impulse (GO:0019226)3.46832779
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.46704907
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45488858
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42794248
54cellular potassium ion homeostasis (GO:0030007)3.42729957
55long-term synaptic potentiation (GO:0060291)3.42481777
56auditory behavior (GO:0031223)3.41454136
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.41406731
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.41286459
59regulation of neurotransmitter secretion (GO:0046928)3.38838546
60activation of protein kinase A activity (GO:0034199)3.38342472
61behavioral defense response (GO:0002209)3.35564245
62behavioral fear response (GO:0001662)3.35564245
63regulation of vesicle fusion (GO:0031338)3.33114800
64regulation of synapse maturation (GO:0090128)3.31433710
65neurotransmitter transport (GO:0006836)3.31071748
66mitochondrion transport along microtubule (GO:0047497)3.29460506
67establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.29460506
68synaptic vesicle endocytosis (GO:0048488)3.29099942
69neuromuscular process controlling balance (GO:0050885)3.27908629
70positive regulation of synapse assembly (GO:0051965)3.27357482
71cell migration in hindbrain (GO:0021535)3.27181819
72regulation of dendritic spine development (GO:0060998)3.26352881
73positive regulation of neurotransmitter secretion (GO:0001956)3.26166838
74presynaptic membrane organization (GO:0097090)3.25475500
75dendritic spine organization (GO:0097061)3.23219050
76response to auditory stimulus (GO:0010996)3.22862729
77synapse assembly (GO:0007416)3.20489957
78L-amino acid import (GO:0043092)3.20301781
79neuromuscular synaptic transmission (GO:0007274)3.19868719
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.19223534
81response to histamine (GO:0034776)3.19168190
82positive regulation of dendritic spine development (GO:0060999)3.18400712
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17765786
84axon ensheathment in central nervous system (GO:0032291)3.16871180
85central nervous system myelination (GO:0022010)3.16871180
86cerebellar granule cell differentiation (GO:0021707)3.15901464
87learning (GO:0007612)3.15666848
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13533340
89fear response (GO:0042596)3.13352293
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13234586
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12448049
92regulation of neurotransmitter transport (GO:0051588)3.10542384
93cerebellar Purkinje cell differentiation (GO:0021702)3.09242393
94innervation (GO:0060384)3.09200555
95membrane depolarization (GO:0051899)3.08789608
96positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07748323
97regulation of neurotransmitter levels (GO:0001505)3.05241356
98* central nervous system projection neuron axonogenesis (GO:0021952)3.02701874
99cell communication by electrical coupling (GO:0010644)3.02484518
100membrane assembly (GO:0071709)3.01531026
101positive regulation of neurotransmitter transport (GO:0051590)3.00019550
102startle response (GO:0001964)2.98483211
103regulation of synaptic transmission (GO:0050804)2.97926421
104sodium ion export (GO:0071436)2.96263957
105pyrimidine nucleobase catabolic process (GO:0006208)2.95829066
106membrane depolarization during action potential (GO:0086010)2.95639880
107mechanosensory behavior (GO:0007638)2.94826831
108synaptic transmission (GO:0007268)2.91652503
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90991303
110positive regulation of synaptic transmission (GO:0050806)2.90600684
111intraspecies interaction between organisms (GO:0051703)2.90393622
112social behavior (GO:0035176)2.90393622
113synapse organization (GO:0050808)2.89370357
114amino acid import (GO:0043090)2.88187116
115neuromuscular process (GO:0050905)2.87540556
116adult walking behavior (GO:0007628)2.87218440
117regulation of synapse assembly (GO:0051963)2.86785636
118adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79637845
119potassium ion homeostasis (GO:0055075)2.79273405
120suckling behavior (GO:0001967)2.75744663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40864434
2GBX2_23144817_ChIP-Seq_PC3_Human3.74791697
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14118734
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07896428
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05097458
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71447967
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71447967
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63260973
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62845426
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58827511
11REST_21632747_ChIP-Seq_MESCs_Mouse2.58610590
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.56475547
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51049772
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43661795
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41436580
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.37118075
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.36382960
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.35673206
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23595547
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22567583
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.22127156
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20281983
23AR_21572438_ChIP-Seq_LNCaP_Human2.11101364
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06699057
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.03929799
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93149083
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90399945
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88893651
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86650816
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85689870
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74979895
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73157385
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69066380
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67048793
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.63278457
36TAF15_26573619_Chip-Seq_HEK293_Human1.62080681
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52979143
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51670331
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.45827069
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43278442
41ZNF274_21170338_ChIP-Seq_K562_Hela1.42864410
42P300_19829295_ChIP-Seq_ESCs_Human1.42616327
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40236570
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39331950
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.39239611
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.39066508
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.38424271
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.36621943
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.32674156
50AR_25329375_ChIP-Seq_VCAP_Human1.31068764
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25792753
52* STAT3_23295773_ChIP-Seq_U87_Human1.24409080
53AR_19668381_ChIP-Seq_PC3_Human1.23561513
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23458148
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23204813
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.22852919
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21839133
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20766348
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20237362
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17793058
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.17695783
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17317047
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17284687
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16545724
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15822490
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14829796
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14453132
68LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13775230
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13728269
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.13641829
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13140716
72AHR_22903824_ChIP-Seq_MCF-7_Human1.12331674
73RNF2_27304074_Chip-Seq_NSC_Mouse1.10352599
74* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10292316
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10165383
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09859384
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09760380
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09734936
79* TCF4_23295773_ChIP-Seq_U87_Human1.09705708
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09304526
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09291785
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08596005
83TP53_16413492_ChIP-PET_HCT116_Human1.07951961
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07802273
85FUS_26573619_Chip-Seq_HEK293_Human1.07607958
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06912096
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05930302
88IGF1R_20145208_ChIP-Seq_DFB_Human1.05664256
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05337995
90SOX9_26525672_Chip-Seq_HEART_Mouse1.05242343
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05117659
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04865257
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04865257
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.02549509
95TP53_18474530_ChIP-ChIP_U2OS_Human1.01923891
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01574267
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.01251513
98* RUNX2_22187159_ChIP-Seq_PCA_Human0.99778159
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97843636
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95847433
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95647491
102* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95293934
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95248946
104KDM2B_26808549_Chip-Seq_REH_Human0.95182445
105KDM2B_26808549_Chip-Seq_K562_Human0.94901000
106JUN_21703547_ChIP-Seq_K562_Human0.94448747
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94106124
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.94011070
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92521220
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.92137238
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.91753375
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91736325
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91572289
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90659510
115* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90637825
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89087070
117RXR_22108803_ChIP-Seq_LS180_Human0.88192365
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88142667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.73169106
2MP0003880_abnormal_central_pattern4.70931528
3MP0003635_abnormal_synaptic_transmissio4.25453163
4MP0004270_analgesia4.01473311
5MP0002063_abnormal_learning/memory/cond3.51112160
6MP0009745_abnormal_behavioral_response3.45230066
7MP0002064_seizures3.03947984
8MP0001968_abnormal_touch/_nociception3.02591093
9MP0009046_muscle_twitch2.91099362
10MP0002572_abnormal_emotion/affect_behav2.88216626
11MP0005423_abnormal_somatic_nervous2.84101974
12MP0002734_abnormal_mechanical_nocicepti2.70537722
13MP0001486_abnormal_startle_reflex2.55950287
14MP0002735_abnormal_chemical_nociception2.37642256
15MP0002736_abnormal_nociception_after2.35495756
16MP0002272_abnormal_nervous_system2.32317809
17MP0001440_abnormal_grooming_behavior2.29647633
18MP0009780_abnormal_chondrocyte_physiolo2.28327979
19MP0002822_catalepsy2.27811321
20* MP0000778_abnormal_nervous_system2.12220980
21MP0001501_abnormal_sleep_pattern2.08774374
22MP0002733_abnormal_thermal_nociception2.06417123
23MP0004858_abnormal_nervous_system1.99038299
24MP0002067_abnormal_sensory_capabilities1.96337655
25MP0002184_abnormal_innervation1.93684127
26MP0001970_abnormal_pain_threshold1.92867982
27MP0003329_amyloid_beta_deposits1.88370997
28MP0002557_abnormal_social/conspecific_i1.87759134
29MP0008569_lethality_at_weaning1.84104112
30MP0004811_abnormal_neuron_physiology1.79545829
31MP0004924_abnormal_behavior1.74603038
32MP0005386_behavior/neurological_phenoty1.74603038
33MP0003879_abnormal_hair_cell1.63497871
34MP0005646_abnormal_pituitary_gland1.61365087
35MP0000955_abnormal_spinal_cord1.58912442
36MP0004885_abnormal_endolymph1.57998699
37MP0001984_abnormal_olfaction1.53312109
38MP0003787_abnormal_imprinting1.53021860
39MP0002909_abnormal_adrenal_gland1.52420504
40MP0006276_abnormal_autonomic_nervous1.52055621
41* MP0002882_abnormal_neuron_morphology1.44780310
42MP0003121_genomic_imprinting1.44147095
43MP0000569_abnormal_digit_pigmentation1.40142585
44MP0002066_abnormal_motor_capabilities/c1.39493365
45MP0001188_hyperpigmentation1.28513185
46MP0001502_abnormal_circadian_rhythm1.26744935
47MP0003633_abnormal_nervous_system1.26524244
48MP0005645_abnormal_hypothalamus_physiol1.22073428
49MP0001905_abnormal_dopamine_level1.20386719
50* MP0002152_abnormal_brain_morphology1.20168862
51MP0003123_paternal_imprinting1.16985768
52MP0004142_abnormal_muscle_tone1.16315656
53MP0001529_abnormal_vocalization1.12620207
54MP0003631_nervous_system_phenotype1.10277617
55MP0000751_myopathy1.08775316
56MP0001177_atelectasis0.96657966
57MP0002069_abnormal_eating/drinking_beha0.90900151
58MP0003122_maternal_imprinting0.89345332
59MP0005499_abnormal_olfactory_system0.88943101
60MP0005394_taste/olfaction_phenotype0.88943101
61MP0003136_yellow_coat_color0.88657030
62MP0008961_abnormal_basal_metabolism0.85680313
63MP0000631_abnormal_neuroendocrine_gland0.85245612
64MP0004133_heterotaxia0.84990542
65MP0001963_abnormal_hearing_physiology0.84133305
66MP0004145_abnormal_muscle_electrophysio0.83514354
67MP0004085_abnormal_heartbeat0.81367771
68MP0005187_abnormal_penis_morphology0.80954146
69MP0003632_abnormal_nervous_system0.79983106
70MP0003634_abnormal_glial_cell0.79598339
71MP0004742_abnormal_vestibular_system0.79519593
72MP0008872_abnormal_physiological_respon0.78527694
73MP0002229_neurodegeneration0.78349496
74MP0008874_decreased_physiological_sensi0.78288808
75MP0002752_abnormal_somatic_nervous0.77483018
76MP0005171_absent_coat_pigmentation0.77468930
77MP0000604_amyloidosis0.76832128
78MP0000534_abnormal_ureter_morphology0.76245104
79MP0003690_abnormal_glial_cell0.75759568
80MP0001485_abnormal_pinna_reflex0.75451538
81MP0005551_abnormal_eye_electrophysiolog0.75135248
82* MP0003861_abnormal_nervous_system0.72884700
83MP0002751_abnormal_autonomic_nervous0.72768396
84MP0003938_abnormal_ear_development0.72021027
85MP0004215_abnormal_myocardial_fiber0.71847672
86MP0003075_altered_response_to0.71193903
87MP0002081_perinatal_lethality0.71179399
88MP0008877_abnormal_DNA_methylation0.70965674
89MP0002653_abnormal_ependyma_morphology0.70408900
90MP0003137_abnormal_impulse_conducting0.69030551
91MP0002876_abnormal_thyroid_physiology0.68786005
92MP0003119_abnormal_digestive_system0.68295842
93MP0001299_abnormal_eye_distance/0.67308190
94MP0010386_abnormal_urinary_bladder0.66999354
95MP0003890_abnormal_embryonic-extraembry0.64712208
96MP0004233_abnormal_muscle_weight0.64398102
97MP0000566_synostosis0.64133275
98MP0005535_abnormal_body_temperature0.63738366
99* MP0010768_mortality/aging0.63562611
100MP0000579_abnormal_nail_morphology0.63428571
101MP0002090_abnormal_vision0.63019455
102MP0004484_altered_response_of0.62675323
103MP0002234_abnormal_pharynx_morphology0.61985453
104MP0000537_abnormal_urethra_morphology0.61571443
105MP0005409_darkened_coat_color0.61271364
106MP0005253_abnormal_eye_physiology0.61076167
107MP0000026_abnormal_inner_ear0.58844280
108MP0005623_abnormal_meninges_morphology0.58100274
109MP0001664_abnormal_digestion0.57700702
110MP0001943_abnormal_respiration0.56939579
111MP0002837_dystrophic_cardiac_calcinosis0.56240639
112MP0003283_abnormal_digestive_organ0.56114391
113MP0002638_abnormal_pupillary_reflex0.55925611
114MP0000013_abnormal_adipose_tissue0.54445612
115* MP0010769_abnormal_survival0.54002324
116MP0000920_abnormal_myelination0.53105241
117* MP0010770_preweaning_lethality0.52151456
118* MP0002082_postnatal_lethality0.52151456

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.46554882
2Myokymia (HP:0002411)6.19024446
3Focal seizures (HP:0007359)5.59889976
4Epileptic encephalopathy (HP:0200134)5.17357885
5Visual hallucinations (HP:0002367)4.86419960
6Progressive cerebellar ataxia (HP:0002073)4.40277092
7Atonic seizures (HP:0010819)4.13858015
8Febrile seizures (HP:0002373)4.12057478
9Broad-based gait (HP:0002136)3.92239086
10Hyperventilation (HP:0002883)3.82402212
11Absence seizures (HP:0002121)3.78703705
12Generalized tonic-clonic seizures (HP:0002069)3.61130428
13Dialeptic seizures (HP:0011146)3.54826568
14Poor eye contact (HP:0000817)3.48265358
15Supranuclear gaze palsy (HP:0000605)3.47866725
16Action tremor (HP:0002345)3.39814649
17Genetic anticipation (HP:0003743)3.25374895
18Gaze-evoked nystagmus (HP:0000640)3.23176957
19Mutism (HP:0002300)3.18076083
20Drooling (HP:0002307)3.13732378
21Excessive salivation (HP:0003781)3.13732378
22Impaired vibration sensation in the lower limbs (HP:0002166)3.11852763
23Ankle clonus (HP:0011448)3.10226250
24Amblyopia (HP:0000646)3.08184577
25Abnormal social behavior (HP:0012433)3.04649642
26Impaired social interactions (HP:0000735)3.04649642
27Papilledema (HP:0001085)3.01611296
28Urinary bladder sphincter dysfunction (HP:0002839)2.99313079
29Dysdiadochokinesis (HP:0002075)2.99022368
30Truncal ataxia (HP:0002078)2.82946912
31Abnormal eating behavior (HP:0100738)2.82537243
32Depression (HP:0000716)2.82354997
33Abnormality of binocular vision (HP:0011514)2.81797117
34Diplopia (HP:0000651)2.81797117
35Epileptiform EEG discharges (HP:0011182)2.78590393
36Dysmetria (HP:0001310)2.76683440
37Abnormality of the lower motor neuron (HP:0002366)2.73823251
38Fetal akinesia sequence (HP:0001989)2.71627831
39Hemiparesis (HP:0001269)2.70180663
40Cerebral inclusion bodies (HP:0100314)2.67001099
41Stereotypic behavior (HP:0000733)2.66841638
42Megalencephaly (HP:0001355)2.65282409
43Neurofibrillary tangles (HP:0002185)2.63412657
44Impaired smooth pursuit (HP:0007772)2.61567996
45Postural instability (HP:0002172)2.60326722
46Urinary urgency (HP:0000012)2.58900671
47Anxiety (HP:0000739)2.58633419
48Absent speech (HP:0001344)2.56101894
49EEG with generalized epileptiform discharges (HP:0011198)2.54717694
50Torticollis (HP:0000473)2.53953240
51Limb dystonia (HP:0002451)2.48856770
52Amyotrophic lateral sclerosis (HP:0007354)2.45363654
53Hypsarrhythmia (HP:0002521)2.44008467
54Polyphagia (HP:0002591)2.43268019
55Progressive inability to walk (HP:0002505)2.42183524
56Scanning speech (HP:0002168)2.40795454
57Obstructive sleep apnea (HP:0002870)2.38552377
58Termporal pattern (HP:0011008)2.38320301
59Insidious onset (HP:0003587)2.38320301
60Abnormality of the corticospinal tract (HP:0002492)2.37662726
61Inappropriate behavior (HP:0000719)2.37425470
62Focal dystonia (HP:0004373)2.33613692
63Spastic gait (HP:0002064)2.31996741
64Inability to walk (HP:0002540)2.27331696
65Protruding tongue (HP:0010808)2.27259704
66Akinesia (HP:0002304)2.26939020
67Hemiplegia (HP:0002301)2.21747522
68Bradykinesia (HP:0002067)2.21282563
69Blue irides (HP:0000635)2.21011123
70Abnormality of ocular smooth pursuit (HP:0000617)2.20741164
71Aplasia involving bones of the upper limbs (HP:0009823)2.15260757
72Aplasia of the phalanges of the hand (HP:0009802)2.15260757
73Aplasia involving bones of the extremities (HP:0009825)2.15260757
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.14903550
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14903550
76Lower limb muscle weakness (HP:0007340)2.14061157
77Lower limb amyotrophy (HP:0007210)2.11031627
78Split foot (HP:0001839)2.10255283
79Morphological abnormality of the middle ear (HP:0008609)2.08138706
80Generalized myoclonic seizures (HP:0002123)2.07322886
81Abnormality of salivation (HP:0100755)2.06995914
82Status epilepticus (HP:0002133)2.06969928
83Impaired vibratory sensation (HP:0002495)2.06664987
84Morphological abnormality of the pyramidal tract (HP:0002062)2.06637608
85Dysmetric saccades (HP:0000641)2.06507289
86Intention tremor (HP:0002080)2.06085512
87Cutaneous finger syndactyly (HP:0010554)2.04532748
88Agitation (HP:0000713)2.04390805
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03711304
90Craniofacial dystonia (HP:0012179)2.03356957
91Hammertoe (HP:0001765)1.95555329
92Aqueductal stenosis (HP:0002410)1.93217461
93Mild short stature (HP:0003502)1.92374498
94Cutaneous syndactyly (HP:0012725)1.91512505
95Spastic tetraplegia (HP:0002510)1.90309179
96Incomplete penetrance (HP:0003829)1.87141168
97Pointed chin (HP:0000307)1.86637588
98Lissencephaly (HP:0001339)1.84047263
99Hypoplasia of the corpus callosum (HP:0002079)1.82377865
100Hepatoblastoma (HP:0002884)1.82075503
101Neuroendocrine neoplasm (HP:0100634)1.80339948
102Peripheral hypomyelination (HP:0007182)1.79401991
103Pheochromocytoma (HP:0002666)1.78813401
104Gait imbalance (HP:0002141)1.78688967
105Hypoplasia of the brainstem (HP:0002365)1.77888034
106Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77888034
107Gait ataxia (HP:0002066)1.75389281
108Abnormality of the labia minora (HP:0012880)1.75126082
109Neonatal short-limb short stature (HP:0008921)1.74772464
110Sleep apnea (HP:0010535)1.74392840
111Apathy (HP:0000741)1.73039479
112Lower limb asymmetry (HP:0100559)1.72173886
113Bronchomalacia (HP:0002780)1.71920830
114Specific learning disability (HP:0001328)1.70508832
115Failure to thrive in infancy (HP:0001531)1.70014659
116Heterochromia iridis (HP:0001100)1.69437038
117Ulnar claw (HP:0001178)1.68202372
118Cortical dysplasia (HP:0002539)1.67006766
119Generalized hypopigmentation of hair (HP:0011358)1.66780785
120Insomnia (HP:0100785)1.64326729
121Narrow nasal bridge (HP:0000446)1.63440923
122Annular pancreas (HP:0001734)1.62587054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.61196852
2EPHA44.46411805
3NTRK34.41633860
4MAP3K93.59823870
5MAP3K42.96235059
6MAP2K72.77949367
7DAPK22.59413099
8MINK12.58061787
9CASK2.42946611
10NTRK22.38517249
11TNIK2.11290916
12PAK62.01500301
13MAPK131.88042977
14MAP2K41.79667504
15KSR11.75681900
16PLK21.72639164
17KSR21.68297722
18CAMKK11.67064145
19DAPK11.63102339
20MAP3K121.59116795
21PRKD31.58245671
22NTRK11.53890219
23CDK51.53173245
24SIK21.47675608
25RIPK41.47137481
26BCR1.41796936
27PHKG11.37680267
28PHKG21.37680267
29PRPF4B1.33594970
30CDK191.27313863
31PRKCG1.25982887
32LATS21.22258005
33MARK21.11631313
34CAMKK21.10618840
35PNCK1.05918471
36GRK51.04402092
37EPHB20.99850222
38WNK30.99058483
39CAMK2A0.98703976
40MAP3K20.98393975
41TYRO30.97683639
42FES0.97538683
43STK380.97148519
44CDK180.94814097
45CDK150.92754237
46UHMK10.89342364
47TAOK10.88325516
48CDK140.87717908
49SGK4940.85272792
50SGK2230.85272792
51SGK20.84826861
52CAMK2B0.84475366
53DYRK1A0.84410900
54STK110.82117456
55CDK11A0.80758412
56ERBB30.80248241
57CAMK10.79477376
58ROCK20.76819195
59RET0.76394466
60CCNB10.75853870
61PAK30.74544281
62SGK10.73068623
63EPHA30.70699699
64BMPR20.69512466
65ARAF0.66217248
66SGK30.66155446
67RAF10.65923668
68PTK2B0.65183896
69MAP3K130.64768356
70PRKCH0.63776655
71MOS0.61929041
72MAP3K60.61618677
73SCYL20.61365372
74PRKCE0.59892063
75DYRK20.58839467
76OXSR10.57806127
77MAPK120.57062905
78CSNK1G30.57039737
79* CSNK1G20.55897226
80CSNK1A1L0.55319918
81PRKCZ0.55223060
82RIPK10.50543559
83MAPK150.50058974
84ALK0.49412357
85CSNK1G10.49351938
86LMTK20.49299280
87MKNK20.48214369
88PDK10.46731532
89FYN0.46052573
90AKT30.45963773
91CAMK1G0.45833326
92DMPK0.45778853
93ROCK10.45239264
94STK390.44670089
95CSNK1D0.43998693
96ERBB20.43875421
97CSNK1E0.43874350
98PDPK10.42995643
99FGR0.42861057
100FER0.41712958
101* RPS6KA30.41712378
102MUSK0.41171863
103TRIM280.40409579
104CAMK40.39781878
105PKN10.39350251
106PINK10.38572662
107PRKG10.38123546
108CDC42BPA0.38062057
109FGFR20.37508475
110MAP2K10.36968828
111CDK30.35548407
112PDGFRA0.34653251
113WNK10.34617668
114CAMK2G0.33943915
115CAMK2D0.33243090
116RPS6KA20.33126705
117DDR20.33110469
118MAPK100.32928406
119MAP3K70.32331482
120LIMK10.31489269
121DYRK1B0.31454406
122NEK60.31357898
123MAP2K60.30820002
124PRKCB0.30321072
125DAPK30.29869977
126PRKDC0.29695603
127PRKACA0.28597410
128* GSK3B0.27742536

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77057498
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04258434
3Circadian entrainment_Homo sapiens_hsa047132.83942026
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70164051
5Long-term potentiation_Homo sapiens_hsa047202.69930611
6Glutamatergic synapse_Homo sapiens_hsa047242.68585880
7Olfactory transduction_Homo sapiens_hsa047402.66984052
8GABAergic synapse_Homo sapiens_hsa047272.63648983
9Morphine addiction_Homo sapiens_hsa050322.53021517
10Amphetamine addiction_Homo sapiens_hsa050312.45322179
11Dopaminergic synapse_Homo sapiens_hsa047282.19853570
12Salivary secretion_Homo sapiens_hsa049702.12602048
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08799248
14Cholinergic synapse_Homo sapiens_hsa047251.94601668
15Insulin secretion_Homo sapiens_hsa049111.90748796
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80279431
17Gastric acid secretion_Homo sapiens_hsa049711.80118920
18Long-term depression_Homo sapiens_hsa047301.72592623
19Taste transduction_Homo sapiens_hsa047421.70790868
20Oxytocin signaling pathway_Homo sapiens_hsa049211.68982537
21Cocaine addiction_Homo sapiens_hsa050301.68307618
22Renin secretion_Homo sapiens_hsa049241.67957576
23Serotonergic synapse_Homo sapiens_hsa047261.67763242
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62525490
25Calcium signaling pathway_Homo sapiens_hsa040201.56862401
26GnRH signaling pathway_Homo sapiens_hsa049121.43972989
27Axon guidance_Homo sapiens_hsa043601.42380072
28Gap junction_Homo sapiens_hsa045401.41710827
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39235062
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36596385
31cAMP signaling pathway_Homo sapiens_hsa040241.29515115
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27394465
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26282649
34Glioma_Homo sapiens_hsa052141.19434142
35Estrogen signaling pathway_Homo sapiens_hsa049151.18958318
36Type II diabetes mellitus_Homo sapiens_hsa049301.16929270
37Collecting duct acid secretion_Homo sapiens_hsa049661.16684664
38ErbB signaling pathway_Homo sapiens_hsa040121.14729132
39Melanogenesis_Homo sapiens_hsa049161.11379172
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05386348
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04884035
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02327029
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98496850
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.89954832
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.85329857
46Oocyte meiosis_Homo sapiens_hsa041140.83006981
47Hippo signaling pathway_Homo sapiens_hsa043900.81024882
48Dorso-ventral axis formation_Homo sapiens_hsa043200.79635558
49Dilated cardiomyopathy_Homo sapiens_hsa054140.77957837
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77227315
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77021145
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76715241
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76217019
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75869365
55Choline metabolism in cancer_Homo sapiens_hsa052310.75807159
56MAPK signaling pathway_Homo sapiens_hsa040100.74711173
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74694779
58Vibrio cholerae infection_Homo sapiens_hsa051100.74213638
59Phototransduction_Homo sapiens_hsa047440.73591733
60Pancreatic secretion_Homo sapiens_hsa049720.73531567
61Cardiac muscle contraction_Homo sapiens_hsa042600.72967682
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.70421974
63Thyroid hormone synthesis_Homo sapiens_hsa049180.69875244
64Hedgehog signaling pathway_Homo sapiens_hsa043400.67027902
65Tight junction_Homo sapiens_hsa045300.66803765
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66767399
67Ras signaling pathway_Homo sapiens_hsa040140.66565757
68Circadian rhythm_Homo sapiens_hsa047100.66162203
69Vitamin B6 metabolism_Homo sapiens_hsa007500.64470057
70VEGF signaling pathway_Homo sapiens_hsa043700.64229940
71Rap1 signaling pathway_Homo sapiens_hsa040150.64130795
72Nitrogen metabolism_Homo sapiens_hsa009100.63862083
73Endometrial cancer_Homo sapiens_hsa052130.62643982
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60796810
75Wnt signaling pathway_Homo sapiens_hsa043100.57254442
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57200976
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.56951803
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56643334
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55514049
80Alcoholism_Homo sapiens_hsa050340.53053539
81Glucagon signaling pathway_Homo sapiens_hsa049220.52920383
82Basal cell carcinoma_Homo sapiens_hsa052170.52174048
83mTOR signaling pathway_Homo sapiens_hsa041500.49629911
84Renal cell carcinoma_Homo sapiens_hsa052110.49334178
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49228019
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48111625
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46615667
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44892041
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44807057
90Colorectal cancer_Homo sapiens_hsa052100.44672792
91Non-small cell lung cancer_Homo sapiens_hsa052230.43344422
92Inositol phosphate metabolism_Homo sapiens_hsa005620.42601113
93Endocytosis_Homo sapiens_hsa041440.42339756
94Bile secretion_Homo sapiens_hsa049760.41767725
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41731599
96Insulin signaling pathway_Homo sapiens_hsa049100.41671022
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40412545
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39939128
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39399236
100Protein digestion and absorption_Homo sapiens_hsa049740.39025473
101Adherens junction_Homo sapiens_hsa045200.38321293
102Prion diseases_Homo sapiens_hsa050200.37825740
103African trypanosomiasis_Homo sapiens_hsa051430.37261063
104Ovarian steroidogenesis_Homo sapiens_hsa049130.36646159
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36376650
106Alzheimers disease_Homo sapiens_hsa050100.35703612
107Type I diabetes mellitus_Homo sapiens_hsa049400.34160081
108Fatty acid biosynthesis_Homo sapiens_hsa000610.34055451
109AMPK signaling pathway_Homo sapiens_hsa041520.33148561
110Chemokine signaling pathway_Homo sapiens_hsa040620.33102842
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32125506
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29385513
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28839583
114Melanoma_Homo sapiens_hsa052180.28534245

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