DCLK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.50548662
2presynaptic membrane assembly (GO:0097105)5.30221496
3locomotory exploration behavior (GO:0035641)5.11093770
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04853662
5synaptic vesicle maturation (GO:0016188)4.92750812
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85389330
7cell migration in hindbrain (GO:0021535)4.67673710
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67179724
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63764202
10neuron cell-cell adhesion (GO:0007158)4.50416973
11vocalization behavior (GO:0071625)4.48324530
12axon ensheathment in central nervous system (GO:0032291)4.47942581
13central nervous system myelination (GO:0022010)4.47942581
14regulation of glutamate receptor signaling pathway (GO:1900449)4.18243919
15protein localization to synapse (GO:0035418)4.17245020
16regulation of synapse structural plasticity (GO:0051823)4.07338083
17synaptic vesicle exocytosis (GO:0016079)4.06145835
18dendritic spine morphogenesis (GO:0060997)4.05820149
19glutamate secretion (GO:0014047)4.03789481
20neuron recognition (GO:0008038)4.02137734
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.01842067
22axonal fasciculation (GO:0007413)4.01744589
23positive regulation of synapse maturation (GO:0090129)4.00293238
24exploration behavior (GO:0035640)3.92284135
25regulation of synaptic vesicle exocytosis (GO:2000300)3.89450737
26dendrite morphogenesis (GO:0048813)3.83004322
27establishment of mitochondrion localization (GO:0051654)3.75878774
28nucleobase catabolic process (GO:0046113)3.74387320
29central nervous system projection neuron axonogenesis (GO:0021952)3.73558675
30regulation of neuronal synaptic plasticity (GO:0048168)3.67211212
31synaptic transmission, glutamatergic (GO:0035249)3.64417522
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.63839427
33glutamate receptor signaling pathway (GO:0007215)3.62710123
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.59861252
35proline transport (GO:0015824)3.56846590
36regulation of dendritic spine morphogenesis (GO:0061001)3.56054960
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53663487
38regulation of synaptic vesicle transport (GO:1902803)3.52412599
39neurotransmitter secretion (GO:0007269)3.48961084
40dermatan sulfate biosynthetic process (GO:0030208)3.46449819
41gamma-aminobutyric acid transport (GO:0015812)3.37915548
42establishment of nucleus localization (GO:0040023)3.36960343
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.36338432
44L-amino acid import (GO:0043092)3.35702522
45neuromuscular process controlling balance (GO:0050885)3.35591821
46mechanosensory behavior (GO:0007638)3.34756990
47cerebellar Purkinje cell differentiation (GO:0021702)3.34368333
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32101758
49neurotransmitter-gated ion channel clustering (GO:0072578)3.22736489
50glial cell proliferation (GO:0014009)3.22233370
51amino acid import (GO:0043090)3.21757716
52neuron-neuron synaptic transmission (GO:0007270)3.20219351
53innervation (GO:0060384)3.19575625
54dermatan sulfate metabolic process (GO:0030205)3.18120712
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17079071
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13802931
57startle response (GO:0001964)3.12951993
58astrocyte differentiation (GO:0048708)3.11260890
59auditory behavior (GO:0031223)3.11164178
60synaptic vesicle endocytosis (GO:0048488)3.11015022
61prepulse inhibition (GO:0060134)3.09215764
62pyrimidine nucleobase catabolic process (GO:0006208)3.08098098
63positive regulation of dendritic spine development (GO:0060999)3.06709161
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06270002
65hippocampus development (GO:0021766)3.06082340
66long-term memory (GO:0007616)3.05964494
67astrocyte development (GO:0014002)3.04440679
68positive regulation of membrane potential (GO:0045838)3.04171876
69neuronal ion channel clustering (GO:0045161)3.02898617
70negative regulation of oligodendrocyte differentiation (GO:0048715)2.97455487
71postsynaptic membrane organization (GO:0001941)2.97412086
72membrane assembly (GO:0071709)2.97257535
73axon extension (GO:0048675)2.96576712
74cerebellar granule cell differentiation (GO:0021707)2.95009008
75response to pheromone (GO:0019236)2.94649639
76positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93874784
77behavioral defense response (GO:0002209)2.92469202
78behavioral fear response (GO:0001662)2.92469202
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92129946
80regulation of synapse maturation (GO:0090128)2.92024644
81regulation of postsynaptic membrane potential (GO:0060078)2.91971338
82regulation of axon extension involved in axon guidance (GO:0048841)2.91436015
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90215799
84neuronal action potential propagation (GO:0019227)2.88923396
85transmission of nerve impulse (GO:0019226)2.88834078
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88159680
87dendritic spine organization (GO:0097061)2.87679559
88adult walking behavior (GO:0007628)2.85069852
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84836572
90regulation of axon guidance (GO:1902667)2.84288984
91potassium ion homeostasis (GO:0055075)2.84262263
92regulation of synapse assembly (GO:0051963)2.84246958
93substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.83910053
94substrate-independent telencephalic tangential migration (GO:0021826)2.83910053
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83500548
96regulation of synaptic plasticity (GO:0048167)2.82794974
97regulation of respiratory system process (GO:0044065)2.82290966
98response to auditory stimulus (GO:0010996)2.81547009
99sodium ion export (GO:0071436)2.80400493
100regulation of dendritic spine development (GO:0060998)2.80167548
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.79179154
102potassium ion import (GO:0010107)2.79010542
103cell communication by electrical coupling (GO:0010644)2.78959204
104negative regulation of microtubule polymerization (GO:0031115)2.78308021
105presynaptic membrane organization (GO:0097090)2.75337161
106neuron projection regeneration (GO:0031102)2.75305442
107central nervous system neuron axonogenesis (GO:0021955)2.74853050
108negative regulation of axonogenesis (GO:0050771)2.73205519
109cerebellum development (GO:0021549)2.71762389
110synapse organization (GO:0050808)2.70079368
111neurotransmitter transport (GO:0006836)2.70014640
112cerebral cortex radially oriented cell migration (GO:0021799)2.68358807
113cellular potassium ion homeostasis (GO:0030007)2.68056149
114membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67760004
115mitochondrion transport along microtubule (GO:0047497)2.66760609
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66760609
117positive regulation of synapse assembly (GO:0051965)2.65412861
118organelle transport along microtubule (GO:0072384)2.64675026
119glycine transport (GO:0015816)2.64349780
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64316710
121clathrin coat assembly (GO:0048268)2.64247175
122synapse assembly (GO:0007416)2.64087649
123neuromuscular process (GO:0050905)2.63949712
124cerebellar Purkinje cell layer development (GO:0021680)2.63233265
125cerebral cortex neuron differentiation (GO:0021895)2.63010385
126spinal cord development (GO:0021510)2.62032263
127fear response (GO:0042596)2.61773301
128dopamine receptor signaling pathway (GO:0007212)2.61539047
129regulation of synapse organization (GO:0050807)2.59274268
130regulation of synaptic transmission, GABAergic (GO:0032228)2.58820091
131negative regulation of axon extension (GO:0030517)2.58382024
132negative regulation of neurotransmitter transport (GO:0051589)2.57228457
133calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56114647
134camera-type eye morphogenesis (GO:0048593)2.55834234
135negative regulation of neurotransmitter secretion (GO:0046929)2.55209738
136suckling behavior (GO:0001967)2.53969524
137neuronal stem cell maintenance (GO:0097150)2.53102595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89968792
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.82115017
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81933252
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77415424
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64615859
6REST_21632747_ChIP-Seq_MESCs_Mouse2.64073855
7GBX2_23144817_ChIP-Seq_PC3_Human2.62605230
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.62423687
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51575358
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50768710
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50768710
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.47233408
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43190126
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32226762
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.27347456
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25035829
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.21243294
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.13672432
19DROSHA_22980978_ChIP-Seq_HELA_Human2.10805837
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09274700
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05171778
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04379244
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03690772
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00980330
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00015096
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96524482
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92755068
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91581137
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.88356787
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.75333679
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72363290
32* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68597768
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63084531
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62775701
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62246102
36RING1B_27294783_Chip-Seq_NPCs_Mouse1.61817982
37KDM2B_26808549_Chip-Seq_K562_Human1.60213191
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58021669
39AR_21572438_ChIP-Seq_LNCaP_Human1.57811573
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57438328
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56777379
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56736052
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.56695965
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.52054333
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49756780
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44926719
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44854838
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39713959
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38650714
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37796188
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33687444
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33595706
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32473857
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31887523
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.30690882
56* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30387426
57TAF15_26573619_Chip-Seq_HEK293_Human1.29260860
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.29046744
59OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28466273
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26197689
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25622451
62RNF2_27304074_Chip-Seq_NSC_Mouse1.24164147
63AR_19668381_ChIP-Seq_PC3_Human1.23811535
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23612621
65* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23229250
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22876769
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22638439
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22360490
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21406942
70ZNF274_21170338_ChIP-Seq_K562_Hela1.21038320
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.20620415
72* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18970146
73SMAD4_21799915_ChIP-Seq_A2780_Human1.16484544
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15175139
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.13111677
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12198390
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11342726
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.10506867
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10184205
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09692679
81* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08952759
82STAT3_23295773_ChIP-Seq_U87_Human1.08149327
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07292229
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06920061
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06901466
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06804608
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05817625
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05482490
89P300_19829295_ChIP-Seq_ESCs_Human1.05214499
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.04599333
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.03825396
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.03538373
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03210445
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02990782
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01313436
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.00416811
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00378079
98IGF1R_20145208_ChIP-Seq_DFB_Human0.99434122
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98957984
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98957984
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.98311896
102NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98212857
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98039442
104POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97278212
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97107300
106SMAD3_21741376_ChIP-Seq_EPCs_Human0.94621793
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93411325
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93230737
109KDM2B_26808549_Chip-Seq_DND41_Human0.93052444
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.92624909
111* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92464734
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.91874626
113WDR5_24793694_ChIP-Seq_LNCAP_Human0.91029352
114SOX9_26525672_Chip-Seq_HEART_Mouse0.90608598
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90547653
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.90319663
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90095479
118TP53_16413492_ChIP-PET_HCT116_Human0.89731965
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89710165
120CTCF_27219007_Chip-Seq_Bcells_Human0.89001495
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88923130
122ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87667220
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86758926
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85386876
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84983706
126TCF4_23295773_ChIP-Seq_U87_Human0.84453094
127AR_25329375_ChIP-Seq_VCAP_Human0.84099122
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.84064824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.73633109
2MP0003880_abnormal_central_pattern3.74789967
3* MP0003635_abnormal_synaptic_transmissio3.45460044
4MP0004270_analgesia3.25782065
5MP0005423_abnormal_somatic_nervous3.13499531
6MP0002063_abnormal_learning/memory/cond2.96541914
7MP0000778_abnormal_nervous_system2.75318265
8MP0009745_abnormal_behavioral_response2.56884735
9MP0000569_abnormal_digit_pigmentation2.34710196
10MP0002572_abnormal_emotion/affect_behav2.32605966
11MP0002653_abnormal_ependyma_morphology2.32006432
12* MP0002064_seizures2.29502513
13MP0009046_muscle_twitch2.27846540
14MP0001486_abnormal_startle_reflex2.20322401
15MP0002734_abnormal_mechanical_nocicepti2.16962935
16MP0003787_abnormal_imprinting2.14470902
17MP0004858_abnormal_nervous_system2.12610518
18MP0001968_abnormal_touch/_nociception2.10436659
19MP0003136_yellow_coat_color2.07927523
20MP0002184_abnormal_innervation2.02432705
21MP0004885_abnormal_endolymph1.99600059
22MP0004811_abnormal_neuron_physiology1.89288079
23MP0000955_abnormal_spinal_cord1.88029778
24MP0002733_abnormal_thermal_nociception1.84665160
25MP0002272_abnormal_nervous_system1.82530822
26MP0002557_abnormal_social/conspecific_i1.73077524
27MP0003690_abnormal_glial_cell1.68939707
28MP0002736_abnormal_nociception_after1.64028299
29MP0002067_abnormal_sensory_capabilities1.61400621
30MP0005394_taste/olfaction_phenotype1.59678728
31MP0005499_abnormal_olfactory_system1.59678728
32MP0001970_abnormal_pain_threshold1.57577641
33MP0002822_catalepsy1.56993018
34MP0006292_abnormal_olfactory_placode1.54917687
35* MP0002882_abnormal_neuron_morphology1.54044164
36* MP0002152_abnormal_brain_morphology1.50946487
37MP0001440_abnormal_grooming_behavior1.50100097
38MP0006276_abnormal_autonomic_nervous1.48199004
39MP0004924_abnormal_behavior1.47898986
40MP0005386_behavior/neurological_phenoty1.47898986
41MP0003861_abnormal_nervous_system1.47184011
42MP0008569_lethality_at_weaning1.45840580
43MP0002735_abnormal_chemical_nociception1.44340854
44MP0009780_abnormal_chondrocyte_physiolo1.39598131
45MP0003879_abnormal_hair_cell1.38376485
46MP0005646_abnormal_pituitary_gland1.33587314
47MP0000631_abnormal_neuroendocrine_gland1.32728490
48MP0001984_abnormal_olfaction1.30084250
49MP0002066_abnormal_motor_capabilities/c1.27921966
50MP0003119_abnormal_digestive_system1.23973513
51MP0003329_amyloid_beta_deposits1.23018244
52MP0002909_abnormal_adrenal_gland1.19730845
53MP0001529_abnormal_vocalization1.17023387
54MP0003121_genomic_imprinting1.16823562
55MP0001188_hyperpigmentation1.16459625
56MP0008789_abnormal_olfactory_epithelium1.15122201
57MP0003283_abnormal_digestive_organ1.14784209
58MP0005187_abnormal_penis_morphology1.14078374
59MP0001502_abnormal_circadian_rhythm1.13693666
60MP0002102_abnormal_ear_morphology1.09767499
61MP0001485_abnormal_pinna_reflex1.08989270
62MP0001501_abnormal_sleep_pattern1.08504793
63MP0008877_abnormal_DNA_methylation1.04400655
64MP0004142_abnormal_muscle_tone1.04319087
65MP0000534_abnormal_ureter_morphology1.03087515
66MP0001177_atelectasis1.03020694
67MP0000920_abnormal_myelination1.02935158
68MP0005171_absent_coat_pigmentation1.01943190
69MP0002752_abnormal_somatic_nervous1.00548947
70MP0004233_abnormal_muscle_weight1.00305148
71MP0003122_maternal_imprinting1.00230977
72MP0002249_abnormal_larynx_morphology0.97451213
73MP0000049_abnormal_middle_ear0.95980081
74MP0003890_abnormal_embryonic-extraembry0.95921689
75MP0005503_abnormal_tendon_morphology0.93328658
76MP0005645_abnormal_hypothalamus_physiol0.93173141
77MP0005551_abnormal_eye_electrophysiolog0.90988762
78MP0008961_abnormal_basal_metabolism0.90307051
79MP0004133_heterotaxia0.87400078
80MP0010030_abnormal_orbit_morphology0.87215035
81MP0002234_abnormal_pharynx_morphology0.84960890
82MP0002069_abnormal_eating/drinking_beha0.84239560
83MP0001963_abnormal_hearing_physiology0.84206251
84MP0001348_abnormal_lacrimal_gland0.82598969
85MP0009379_abnormal_foot_pigmentation0.82358349
86MP0001958_emphysema0.81599329
87MP0002081_perinatal_lethality0.81098006
88MP0003634_abnormal_glial_cell0.81047817
89MP0006072_abnormal_retinal_apoptosis0.80749616
90MP0003938_abnormal_ear_development0.80652739
91MP0000537_abnormal_urethra_morphology0.80617782
92MP0005409_darkened_coat_color0.78097744
93MP0003632_abnormal_nervous_system0.77372111
94MP0002751_abnormal_autonomic_nervous0.76649912
95MP0005623_abnormal_meninges_morphology0.76540956
96MP0000026_abnormal_inner_ear0.76325827
97MP0003942_abnormal_urinary_system0.75935730
98MP0003755_abnormal_palate_morphology0.74762744
99MP0003631_nervous_system_phenotype0.74565672
100MP0005248_abnormal_Harderian_gland0.74524920
101MP0002116_abnormal_craniofacial_bone0.73948888
102MP0003633_abnormal_nervous_system0.73435917
103MP0003137_abnormal_impulse_conducting0.72892998
104MP0002638_abnormal_pupillary_reflex0.72496328
105MP0005253_abnormal_eye_physiology0.72434343
106MP0000751_myopathy0.72231596
107MP0001905_abnormal_dopamine_level0.71151265
108MP0005167_abnormal_blood-brain_barrier0.70600178
109MP0005257_abnormal_intraocular_pressure0.69791649
110MP0001299_abnormal_eye_distance/0.69045752
111MP0002229_neurodegeneration0.68635131
112MP0004742_abnormal_vestibular_system0.68596481
113MP0001943_abnormal_respiration0.68582662
114* MP0010769_abnormal_survival0.67800949
115MP0005076_abnormal_cell_differentiation0.66364027
116* MP0010770_preweaning_lethality0.65790748
117* MP0002082_postnatal_lethality0.65790748

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.84472622
2Focal motor seizures (HP:0011153)4.02756088
3Neurofibrillary tangles (HP:0002185)3.79976499
4Focal seizures (HP:0007359)3.63710350
5Epileptic encephalopathy (HP:0200134)3.14256060
6Abnormality of the lower motor neuron (HP:0002366)3.13420265
7Progressive cerebellar ataxia (HP:0002073)3.11929755
8Visual hallucinations (HP:0002367)2.97458407
9Ankle clonus (HP:0011448)2.95759705
10Insomnia (HP:0100785)2.86175280
11Febrile seizures (HP:0002373)2.85533961
12Action tremor (HP:0002345)2.83995034
13Supranuclear gaze palsy (HP:0000605)2.82828338
14Split foot (HP:0001839)2.75876947
15Hyperacusis (HP:0010780)2.75846325
16Cerebral inclusion bodies (HP:0100314)2.71823082
17Megalencephaly (HP:0001355)2.70661371
18Atonic seizures (HP:0010819)2.68813686
19Polyphagia (HP:0002591)2.62692973
20Urinary bladder sphincter dysfunction (HP:0002839)2.61599440
21Neonatal short-limb short stature (HP:0008921)2.61229679
22Impaired vibration sensation in the lower limbs (HP:0002166)2.60099730
23Genetic anticipation (HP:0003743)2.59379744
24Abnormality of the astrocytes (HP:0100707)2.55190542
25Astrocytoma (HP:0009592)2.55190542
26Excessive salivation (HP:0003781)2.52807894
27Drooling (HP:0002307)2.52807894
28Pointed chin (HP:0000307)2.52678871
29Oligodactyly (hands) (HP:0001180)2.52145741
30Hemiparesis (HP:0001269)2.49429748
31Amyotrophic lateral sclerosis (HP:0007354)2.48250362
32Hyperventilation (HP:0002883)2.44115472
33Termporal pattern (HP:0011008)2.43791441
34Insidious onset (HP:0003587)2.43791441
35Diplopia (HP:0000651)2.42626337
36Abnormality of binocular vision (HP:0011514)2.42626337
37Morphological abnormality of the middle ear (HP:0008609)2.42567111
38Abnormality of the corticospinal tract (HP:0002492)2.42499355
39Urinary urgency (HP:0000012)2.37925352
40Absence seizures (HP:0002121)2.36891771
41Broad-based gait (HP:0002136)2.36862397
42Turricephaly (HP:0000262)2.34691122
43Limb dystonia (HP:0002451)2.33168337
44Abnormality of the labia minora (HP:0012880)2.32571203
45Peripheral hypomyelination (HP:0007182)2.30014940
46Tented upper lip vermilion (HP:0010804)2.27293987
47Renal duplication (HP:0000075)2.25982316
48Abnormality of the 4th metacarpal (HP:0010012)2.25549342
49Sleep apnea (HP:0010535)2.24985046
50Poor eye contact (HP:0000817)2.23537571
51Elfin facies (HP:0004428)2.21715878
52Depression (HP:0000716)2.19745965
53Overriding aorta (HP:0002623)2.17330074
54Ankyloglossia (HP:0010296)2.16695844
55Aplasia of the phalanges of the hand (HP:0009802)2.16217773
56Aplasia involving bones of the extremities (HP:0009825)2.16217773
57Aplasia involving bones of the upper limbs (HP:0009823)2.16217773
58Amblyopia (HP:0000646)2.15957730
59Dialeptic seizures (HP:0011146)2.14018846
60Cutaneous finger syndactyly (HP:0010554)2.12066348
61Spastic gait (HP:0002064)2.11358520
62Dysdiadochokinesis (HP:0002075)2.11086071
63Mutism (HP:0002300)2.10389019
64Cortical dysplasia (HP:0002539)2.09518864
65Truncal ataxia (HP:0002078)2.07240408
66Shallow orbits (HP:0000586)2.06413892
67Abnormal social behavior (HP:0012433)2.04063612
68Impaired social interactions (HP:0000735)2.04063612
69Heterotopia (HP:0002282)2.03635560
70Septo-optic dysplasia (HP:0100842)2.03399343
71Apathy (HP:0000741)2.03395857
72Generalized tonic-clonic seizures (HP:0002069)2.00666332
73Annular pancreas (HP:0001734)2.00472716
74Abnormality of the diencephalon (HP:0010662)1.96342440
75Oligodactyly (HP:0012165)1.95541306
76Stereotypic behavior (HP:0000733)1.95332961
77Renovascular hypertension (HP:0100817)1.94046772
78Abnormal eating behavior (HP:0100738)1.93947635
79Sacral dimple (HP:0000960)1.92622804
80Abnormality of the ischium (HP:0003174)1.91996814
81Shoulder girdle muscle weakness (HP:0003547)1.91737157
82Gaze-evoked nystagmus (HP:0000640)1.91721701
83Gait imbalance (HP:0002141)1.91611179
84Obstructive sleep apnea (HP:0002870)1.91101948
85Aqueductal stenosis (HP:0002410)1.91024435
86Ependymoma (HP:0002888)1.90377734
87EEG with generalized epileptiform discharges (HP:0011198)1.90100099
88Impaired smooth pursuit (HP:0007772)1.89546863
89Hypsarrhythmia (HP:0002521)1.89225393
90Pheochromocytoma (HP:0002666)1.88322728
91Dysmetria (HP:0001310)1.88095861
92Glioma (HP:0009733)1.88028575
93Abnormality of chromosome segregation (HP:0002916)1.87955476
94Anomalous pulmonary venous return (HP:0010772)1.87696045
95Lower limb muscle weakness (HP:0007340)1.87619037
96Epileptiform EEG discharges (HP:0011182)1.87421969
97Vertebral arch anomaly (HP:0008438)1.87162340
98Rib fusion (HP:0000902)1.86170487
99Papilledema (HP:0001085)1.86118474
100Lissencephaly (HP:0001339)1.86102050
101Papillary thyroid carcinoma (HP:0002895)1.86018373
102Inappropriate behavior (HP:0000719)1.85166003
103Cutaneous syndactyly (HP:0012725)1.84291813
104Torticollis (HP:0000473)1.84088240
105Pachygyria (HP:0001302)1.82412057
106Hypoplasia of the corpus callosum (HP:0002079)1.82391005
107Neoplasm of the heart (HP:0100544)1.82115193
108Abnormality of ocular smooth pursuit (HP:0000617)1.81828050
109Mild short stature (HP:0003502)1.81797898
110Short 4th metacarpal (HP:0010044)1.81673262
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81673262
112Intention tremor (HP:0002080)1.81640823
113Obsessive-compulsive behavior (HP:0000722)1.81506656
114Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81074199
115Hypoplasia of the brainstem (HP:0002365)1.81074199
116Focal dystonia (HP:0004373)1.79389540
117Diminished motivation (HP:0000745)1.78913884
118Hepatoblastoma (HP:0002884)1.77860566
119Absent speech (HP:0001344)1.75943552
120Autism (HP:0000717)1.75681039
121Bowel diverticulosis (HP:0005222)1.75678539
122Facial hemangioma (HP:0000329)1.74651325
123Broad alveolar ridges (HP:0000187)1.74570022
124Hypoventilation (HP:0002791)1.74326938
125Megalocornea (HP:0000485)1.73256307
126Increased nuchal translucency (HP:0010880)1.72970302
127Wide anterior fontanel (HP:0000260)1.72458109
128Bronchomalacia (HP:0002780)1.71086334
129Vitreoretinal degeneration (HP:0000655)1.69641320
130Fetal akinesia sequence (HP:0001989)1.68853083
131Specific learning disability (HP:0001328)1.68685218
132Generalized hypotonia (HP:0001290)1.68221297
133Hemiplegia (HP:0002301)1.68141831
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.67311812
135Akinesia (HP:0002304)1.67096907
136Flat cornea (HP:0007720)1.66719516
137Hammertoe (HP:0001765)1.64615645
138Abnormality of the pulmonary veins (HP:0011718)1.63703999
139Mitral regurgitation (HP:0001653)1.63632550
140Failure to thrive in infancy (HP:0001531)1.63251386
141Spastic tetraplegia (HP:0002510)1.62577067
142Anxiety (HP:0000739)1.61867488
143Increased circulating renin level (HP:0000848)1.60105960
144Shawl scrotum (HP:0000049)1.58786556
145Postural instability (HP:0002172)1.58765837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.73422022
2MAP3K93.73973097
3EPHA43.26033481
4NTRK32.97666930
5MAP3K42.62818593
6NTRK22.57389380
7PAK62.54670357
8ICK2.41466436
9KSR22.36722121
10KSR12.30514672
11TYRO32.19953115
12MINK12.07611374
13SIK22.03477017
14LATS21.99857809
15MAPK131.87663524
16TAOK11.86714739
17PRKD31.82522097
18MAP2K71.59024039
19CAMKK11.52699768
20DAPK21.50763443
21PKN11.47508367
22UHMK11.35270501
23MARK21.25681541
24PNCK1.23551010
25DYRK21.22946369
26MAPK151.22684263
27ARAF1.22257489
28CDK51.21621207
29CAMK2B1.19037020
30RAF11.18336476
31PINK11.17557785
32MAP2K41.16421994
33NTRK11.14540859
34PHKG11.12954930
35PHKG21.12954930
36MAP3K61.10748278
37STK381.07955968
38BCR1.07661277
39ROCK21.07489171
40CSNK1G21.04991066
41EEF2K1.01116803
42PLK20.99146772
43CDC70.99103816
44CDK150.98803268
45RET0.97593627
46CDK180.97462676
47PRPF4B0.89261918
48DAPK10.88755065
49DDR20.88171837
50CDK140.87984330
51CDK11A0.87967400
52CAMK1G0.86912438
53NEK60.86895697
54ALK0.86163912
55CAMK2G0.84820014
56SGK2230.82067073
57SGK4940.82067073
58EPHA30.81473963
59TRIB30.79821771
60DYRK1A0.78064029
61EPHB20.75852364
62ERBB30.74788761
63CAMK2D0.74188767
64WNK30.74012093
65ROCK10.73922171
66MOS0.72244759
67PRKCG0.70699592
68TNIK0.70111713
69STK110.69611095
70CSNK1A1L0.69394356
71CSNK1G30.69324585
72MAP3K130.67193348
73NEK10.66652164
74SGK20.65348201
75MAP3K20.62792138
76AKT30.62015422
77PDGFRA0.61773323
78PAK30.61398226
79ERBB40.61263827
80SGK30.59957531
81CAMK10.56199786
82PRKCH0.55888780
83BRAF0.55032863
84BMPR20.54703185
85CDC42BPA0.54348658
86PDGFRB0.54271649
87RIPK10.53306301
88BRSK10.53282488
89PRKCZ0.51935096
90SGK10.51620326
91DYRK1B0.48736396
92LMTK20.48714601
93LIMK10.48595313
94CSNK1G10.48212730
95PRKCE0.47906956
96RPS6KA30.47768606
97PRKAA10.47567079
98FES0.47304272
99ERBB20.47253705
100WNK40.47219877
101GRK50.47199933
102CASK0.46941950
103CAMK2A0.46743189
104MAPK100.45962126
105CHEK20.45446825
106PRKD20.45226251
107PTK20.44884306
108FGR0.44777456
109WNK10.43912767
110STK390.43242082
111DMPK0.43021070
112FGFR20.42259748
113LATS10.42124935
114EPHB10.42094876
115PRKG10.41407454
116RPS6KA20.40806448
117SCYL20.40557204
118TAOK20.39589229
119CDK190.38492861
120GSK3B0.38249597
121BRD40.37839134
122CSNK1D0.37837771
123PAK20.36971850
124CDK30.36307612
125MAPK90.35839560
126CSNK1E0.35802357
127NEK20.35508021
128CAMKK20.35396063
129FYN0.35387755
130CAMK40.34386174
131MKNK20.31412184
132PRKD10.31053345

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.04123776
2Glutamatergic synapse_Homo sapiens_hsa047242.38784859
3Synaptic vesicle cycle_Homo sapiens_hsa047212.37076508
4Long-term potentiation_Homo sapiens_hsa047202.33284643
5GABAergic synapse_Homo sapiens_hsa047272.25890028
6Circadian entrainment_Homo sapiens_hsa047132.24994285
7Olfactory transduction_Homo sapiens_hsa047402.23102400
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09112403
9Dopaminergic synapse_Homo sapiens_hsa047281.99227039
10Morphine addiction_Homo sapiens_hsa050321.94993275
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87489655
12Amphetamine addiction_Homo sapiens_hsa050311.87255570
13Axon guidance_Homo sapiens_hsa043601.74087219
14Cholinergic synapse_Homo sapiens_hsa047251.70079476
15Long-term depression_Homo sapiens_hsa047301.67605684
16Oocyte meiosis_Homo sapiens_hsa041141.63845288
17Gap junction_Homo sapiens_hsa045401.61564094
18Salivary secretion_Homo sapiens_hsa049701.57312545
19GnRH signaling pathway_Homo sapiens_hsa049121.55792405
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52050388
21Cocaine addiction_Homo sapiens_hsa050301.51866518
22Oxytocin signaling pathway_Homo sapiens_hsa049211.51355748
23Insulin secretion_Homo sapiens_hsa049111.48118992
24Glioma_Homo sapiens_hsa052141.47787085
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45985018
26Gastric acid secretion_Homo sapiens_hsa049711.42889282
27Endometrial cancer_Homo sapiens_hsa052131.39366137
28ErbB signaling pathway_Homo sapiens_hsa040121.39145463
29mTOR signaling pathway_Homo sapiens_hsa041501.35356009
30Colorectal cancer_Homo sapiens_hsa052101.34854665
31Serotonergic synapse_Homo sapiens_hsa047261.30817933
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29577158
33Taste transduction_Homo sapiens_hsa047421.29262304
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26901719
35Melanogenesis_Homo sapiens_hsa049161.26719295
36Estrogen signaling pathway_Homo sapiens_hsa049151.25722288
37Dorso-ventral axis formation_Homo sapiens_hsa043201.25675998
38Renin secretion_Homo sapiens_hsa049241.24609482
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24503604
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24073338
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20775220
42Calcium signaling pathway_Homo sapiens_hsa040201.13714346
43Type II diabetes mellitus_Homo sapiens_hsa049301.13014308
44cAMP signaling pathway_Homo sapiens_hsa040241.11043948
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10035954
46VEGF signaling pathway_Homo sapiens_hsa043701.08791753
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08635351
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07332223
49Non-small cell lung cancer_Homo sapiens_hsa052231.04465360
50Prion diseases_Homo sapiens_hsa050201.04162469
51Choline metabolism in cancer_Homo sapiens_hsa052311.03683054
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03429471
53Wnt signaling pathway_Homo sapiens_hsa043101.03096312
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.01872784
55Cardiac muscle contraction_Homo sapiens_hsa042601.01369830
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.01314731
57Bile secretion_Homo sapiens_hsa049760.99444228
58Hippo signaling pathway_Homo sapiens_hsa043900.92640123
59Hedgehog signaling pathway_Homo sapiens_hsa043400.92540875
60mRNA surveillance pathway_Homo sapiens_hsa030150.91724413
61Renal cell carcinoma_Homo sapiens_hsa052110.91277146
62Circadian rhythm_Homo sapiens_hsa047100.88944667
63MAPK signaling pathway_Homo sapiens_hsa040100.88783474
64Basal cell carcinoma_Homo sapiens_hsa052170.87943495
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85098958
66Alcoholism_Homo sapiens_hsa050340.84896886
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82294101
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81807556
69Phototransduction_Homo sapiens_hsa047440.79657459
70Rap1 signaling pathway_Homo sapiens_hsa040150.77955617
71MicroRNAs in cancer_Homo sapiens_hsa052060.77749333
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77199076
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74431050
74Pancreatic secretion_Homo sapiens_hsa049720.72713846
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72627509
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72393499
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71707980
78Ras signaling pathway_Homo sapiens_hsa040140.71140847
79Pancreatic cancer_Homo sapiens_hsa052120.70966913
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70178499
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70128260
82Insulin signaling pathway_Homo sapiens_hsa049100.68656618
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68259776
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68004763
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66797793
86Chronic myeloid leukemia_Homo sapiens_hsa052200.65786459
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63801867
88Notch signaling pathway_Homo sapiens_hsa043300.63385856
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.63248782
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.61244814
91Ovarian steroidogenesis_Homo sapiens_hsa049130.60672190
92Adherens junction_Homo sapiens_hsa045200.58868346
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57807585
94Protein digestion and absorption_Homo sapiens_hsa049740.57642461
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57485522
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57203161
97Prolactin signaling pathway_Homo sapiens_hsa049170.56951205
98Glucagon signaling pathway_Homo sapiens_hsa049220.56812017
99ECM-receptor interaction_Homo sapiens_hsa045120.55592664
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54865391
101Endocytosis_Homo sapiens_hsa041440.54854179
102Dilated cardiomyopathy_Homo sapiens_hsa054140.54298847
103Tight junction_Homo sapiens_hsa045300.52554714
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.51879740
105Focal adhesion_Homo sapiens_hsa045100.51782016
106Melanoma_Homo sapiens_hsa052180.51188305
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50823153
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50687050
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47366416
110Bladder cancer_Homo sapiens_hsa052190.47019842
111AMPK signaling pathway_Homo sapiens_hsa041520.47015100
112Cell cycle_Homo sapiens_hsa041100.45279352
113FoxO signaling pathway_Homo sapiens_hsa040680.44323845
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43859220
115Thyroid hormone synthesis_Homo sapiens_hsa049180.43115044
116Vibrio cholerae infection_Homo sapiens_hsa051100.43092359
117Inositol phosphate metabolism_Homo sapiens_hsa005620.42963646
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42945106

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