DCLRE1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.89749620
2nuclear pore complex assembly (GO:0051292)4.86048543
3mitotic sister chromatid segregation (GO:0000070)4.66979734
4sister chromatid segregation (GO:0000819)4.34188224
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89607074
6telomere maintenance via semi-conservative replication (GO:0032201)3.71166006
7pore complex assembly (GO:0046931)3.68838880
8regulation of centriole replication (GO:0046599)3.66207872
9DNA strand elongation involved in DNA replication (GO:0006271)3.63215619
10establishment of integrated proviral latency (GO:0075713)3.59493771
11regulation of spindle organization (GO:0090224)3.58197388
12chromosome condensation (GO:0030261)3.52212034
13* DNA strand elongation (GO:0022616)3.50837843
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49549943
15telomere maintenance via recombination (GO:0000722)3.48203245
16establishment of chromosome localization (GO:0051303)3.44805316
17regulation of centrosome cycle (GO:0046605)3.44162353
18DNA replication initiation (GO:0006270)3.42941676
19folic acid-containing compound biosynthetic process (GO:0009396)3.41537211
20nuclear envelope disassembly (GO:0051081)3.40548914
21membrane disassembly (GO:0030397)3.40548914
22positive regulation of chromosome segregation (GO:0051984)3.39699556
23ribosomal small subunit assembly (GO:0000028)3.39553026
24DNA replication checkpoint (GO:0000076)3.39207913
25definitive hemopoiesis (GO:0060216)3.36493155
26CENP-A containing nucleosome assembly (GO:0034080)3.35375172
27formation of translation preinitiation complex (GO:0001731)3.34706231
28positive regulation of gamma-delta T cell activation (GO:0046645)3.33619930
29maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29106623
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28653530
31DNA duplex unwinding (GO:0032508)3.25946738
32deoxyribonucleotide biosynthetic process (GO:0009263)3.22786360
33chromosome segregation (GO:0007059)3.22718975
34mitotic recombination (GO:0006312)3.22633813
35DNA packaging (GO:0006323)3.22621213
36regulation of double-strand break repair via homologous recombination (GO:0010569)3.19436051
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17717158
38regulation of mammary gland epithelial cell proliferation (GO:0033599)3.17463555
39chromatin assembly or disassembly (GO:0006333)3.17153383
40chromatin remodeling at centromere (GO:0031055)3.16874589
41peptidyl-arginine omega-N-methylation (GO:0035247)3.15345346
42DNA conformation change (GO:0071103)3.14737105
43nucleobase-containing small molecule interconversion (GO:0015949)3.14490500
44telomere maintenance via telomere lengthening (GO:0010833)3.13029471
45DNA replication-dependent nucleosome assembly (GO:0006335)3.12421720
46DNA replication-dependent nucleosome organization (GO:0034723)3.12421720
47DNA geometric change (GO:0032392)3.11065920
48kinetochore organization (GO:0051383)3.10900263
49replication fork processing (GO:0031297)3.09690561
50regulation of translational fidelity (GO:0006450)3.07505165
51DNA unwinding involved in DNA replication (GO:0006268)3.07226267
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.04837315
53DNA deamination (GO:0045006)3.02410230
54regulation of chromatin binding (GO:0035561)3.00523551
55viral mRNA export from host cell nucleus (GO:0046784)3.00461439
56regulation of DNA endoreduplication (GO:0032875)2.98171592
57regulation of mitotic spindle organization (GO:0060236)2.97237668
58base-excision repair (GO:0006284)2.96535740
59negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.96420072
60negative regulation of phagocytosis (GO:0050765)2.95841770
61* telomere organization (GO:0032200)2.95576252
62kinetochore assembly (GO:0051382)2.95456705
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95125589
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93095974
65* telomere maintenance (GO:0000723)2.92530349
66ribosome assembly (GO:0042255)2.91796119
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.91771573
68G1/S transition of mitotic cell cycle (GO:0000082)2.90776562
69cell cycle G1/S phase transition (GO:0044843)2.90776562
70regulation of sister chromatid cohesion (GO:0007063)2.90236922
71mitotic cell cycle (GO:0000278)2.88541409
72ribosome biogenesis (GO:0042254)2.87693553
73regulation of chromosome segregation (GO:0051983)2.87144428
74interferon-gamma production (GO:0032609)2.86751858
75termination of RNA polymerase II transcription (GO:0006369)2.84709607
76DNA replication-independent nucleosome organization (GO:0034724)2.84017658
77DNA replication-independent nucleosome assembly (GO:0006336)2.84017658
78meiotic chromosome segregation (GO:0045132)2.83738678
79IMP biosynthetic process (GO:0006188)2.81926247
80establishment of viral latency (GO:0019043)2.81639824
81cellular protein complex localization (GO:0034629)2.81632587
82ATP-dependent chromatin remodeling (GO:0043044)2.81457798
83protein localization to kinetochore (GO:0034501)2.80389871
84peptidyl-arginine N-methylation (GO:0035246)2.79670036
85peptidyl-arginine methylation (GO:0018216)2.79670036
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79152176
87transcription-coupled nucleotide-excision repair (GO:0006283)2.77484837
88regulation of centrosome duplication (GO:0010824)2.76488134
89regulation of retinoic acid receptor signaling pathway (GO:0048385)2.73943444
90nuclear envelope organization (GO:0006998)2.73788194
91protein localization to chromosome, centromeric region (GO:0071459)2.72846303
92regulation of RNA export from nucleus (GO:0046831)2.72533095
93intra-S DNA damage checkpoint (GO:0031573)2.72461904
94protein complex localization (GO:0031503)2.70977681
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.70124617
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.70124617
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.70124617
98regulation of spindle checkpoint (GO:0090231)2.69893824
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69127156
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.69127156
101ribosomal small subunit biogenesis (GO:0042274)2.68336447
102megakaryocyte development (GO:0035855)2.67979049
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.67951321
104mitotic metaphase plate congression (GO:0007080)2.64763810
105centriole assembly (GO:0098534)2.63513781
106DNA synthesis involved in DNA repair (GO:0000731)2.62649937
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.62284053
108mitotic sister chromatid cohesion (GO:0007064)2.59627413
109nucleobase biosynthetic process (GO:0046112)2.58929235
110protein localization to chromosome (GO:0034502)2.58788762
111centriole replication (GO:0007099)2.58588384
112response to interferon-beta (GO:0035456)2.57415153
113defense response to protozoan (GO:0042832)2.55667656
114myeloid dendritic cell activation (GO:0001773)2.52807482
115regulation of mitotic spindle checkpoint (GO:1903504)2.51699769
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51699769
117regulation of activation of Janus kinase activity (GO:0010533)2.50834584
118DNA-dependent DNA replication (GO:0006261)2.50457778
119DNA topological change (GO:0006265)2.47888901
120response to protozoan (GO:0001562)2.47839366
121positive regulation of B cell differentiation (GO:0045579)2.46566724
122mismatch repair (GO:0006298)2.45326822
123leukocyte aggregation (GO:0070486)2.45192103
124regulation of B cell differentiation (GO:0045577)2.45029317
125negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.42731234
126negative regulation of DNA-templated transcription, elongation (GO:0032785)2.42731234
127purine nucleobase biosynthetic process (GO:0009113)2.42424102
128lymphoid progenitor cell differentiation (GO:0002320)2.42408538
129DNA damage response, signal transduction resulting in transcription (GO:0042772)2.41331705
130histone exchange (GO:0043486)2.41194669
131translesion synthesis (GO:0019985)2.40397846
132mitotic nuclear envelope disassembly (GO:0007077)2.39632363
133IMP metabolic process (GO:0046040)2.38469820
134DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.38158392
135positive regulation of DNA-dependent DNA replication (GO:2000105)2.36529343
136dendritic cell chemotaxis (GO:0002407)2.36517379
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.35694345
138metaphase plate congression (GO:0051310)2.32497595
139DNA strand renaturation (GO:0000733)2.32359041
140DNA ligation (GO:0006266)2.32273151
141daunorubicin metabolic process (GO:0044597)2.32172030
142polyketide metabolic process (GO:0030638)2.32172030
143doxorubicin metabolic process (GO:0044598)2.32172030
144snRNA processing (GO:0016180)2.31948272
145tRNA methylation (GO:0030488)2.30569175
146DNA recombination (GO:0006310)2.29383869
147nuclear pore organization (GO:0006999)2.29293069
148cellular response to interferon-beta (GO:0035458)2.29171996
149histone H2A acetylation (GO:0043968)2.28195687
150deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.28030799
151regulation of B cell receptor signaling pathway (GO:0050855)2.27943325
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26593391
153positive regulation of defense response to virus by host (GO:0002230)2.25746030
154maturation of SSU-rRNA (GO:0030490)2.25448967
155attachment of spindle microtubules to kinetochore (GO:0008608)2.24485648
156negative regulation by host of viral transcription (GO:0043922)2.23688673
157dosage compensation (GO:0007549)2.23458300
158production of molecular mediator involved in inflammatory response (GO:0002532)2.23118034
159dendritic cell migration (GO:0036336)2.22181497
160DNA replication (GO:0006260)2.22133128
161regulation of MHC class II biosynthetic process (GO:0045346)2.21318353
162V(D)J recombination (GO:0033151)2.21282889
163positive regulation of T cell mediated cytotoxicity (GO:0001916)2.21026154
164mitochondrial DNA replication (GO:0006264)2.20662765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31126413
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62835251
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.11529465
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97654747
5SCL_19346495_ChIP-Seq_HPC-7_Human2.77761902
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.74699082
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72813661
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72244293
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.58159203
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.56758703
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.52652548
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44487494
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.41223125
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33718912
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31393123
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.30404074
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.29546187
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17872398
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16980374
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16625177
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16083602
22* VDR_23849224_ChIP-Seq_CD4+_Human2.08929390
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.08174668
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.07266590
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.06282033
26HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02673705
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.00293613
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97129933
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93446727
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.92936312
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.92020270
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90188637
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89858951
34* SPI1_23547873_ChIP-Seq_NB4_Human1.84873648
35* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84734423
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84630144
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.83653895
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83353967
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81745468
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81527521
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80635873
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78828894
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78578707
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78434728
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76735350
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76481215
47* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74096169
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67695951
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67146823
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62407836
51ZNF263_19887448_ChIP-Seq_K562_Human1.62370137
52GATA1_22025678_ChIP-Seq_K562_Human1.59986198
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58768287
54MYC_22102868_ChIP-Seq_BL_Human1.58202516
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56246452
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.55984435
57ELK1_19687146_ChIP-ChIP_HELA_Human1.54950689
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54159790
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.52672524
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.49637837
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46791616
62* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46682052
63XRN2_22483619_ChIP-Seq_HELA_Human1.46308120
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45423331
65MYB_26560356_Chip-Seq_TH2_Human1.43985970
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42098631
67CIITA_25753668_ChIP-Seq_RAJI_Human1.41732883
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41537637
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40828963
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40457630
71* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40080360
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38718103
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38197961
74MYB_26560356_Chip-Seq_TH1_Human1.38093221
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.37590872
76AR_21909140_ChIP-Seq_LNCAP_Human1.35723849
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.34865096
78VDR_21846776_ChIP-Seq_THP-1_Human1.34703487
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34117600
80TFEB_21752829_ChIP-Seq_HELA_Human1.33677845
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32982116
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32342276
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30452973
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27769448
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26761022
86DCP1A_22483619_ChIP-Seq_HELA_Human1.26601935
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26481511
88* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24971361
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24359439
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22990064
91TTF2_22483619_ChIP-Seq_HELA_Human1.19115650
92GABP_19822575_ChIP-Seq_HepG2_Human1.18474817
93RUNX_20019798_ChIP-Seq_JUKART_Human1.18326195
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15456438
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14301935
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14052651
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13090009
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12944131
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12267437
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11865213
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11435748
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09702397
103UTX_26944678_Chip-Seq_JUKART_Human1.07844103
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06870199
105VDR_24763502_ChIP-Seq_THP-1_Human1.06778765
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06315321
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06048793
108IRF1_19129219_ChIP-ChIP_H3396_Human1.05769052
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04987327
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03727611
111KDM5A_27292631_Chip-Seq_BREAST_Human1.03322030
112MAF_26560356_Chip-Seq_TH1_Human1.03278775
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.00447484
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00059626
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99838747
116* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98483535
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97088026
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95712968
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94883138
120CHD1_26751641_Chip-Seq_LNCaP_Human0.94294008
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93251439
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92293215
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89676973
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89540570
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87898645
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87088508
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86408902
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86132347
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85852101
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83328353
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82721624
132* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80933173
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79085434
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.77149191
135* RACK7_27058665_Chip-Seq_MCF-7_Human0.75852863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.47277481
2MP0010094_abnormal_chromosome_stability3.30775090
3MP0008057_abnormal_DNA_replication3.23511728
4MP0008058_abnormal_DNA_repair2.93016939
5MP0003693_abnormal_embryo_hatching2.91948953
6MP0001835_abnormal_antigen_presentation2.87405678
7MP0005671_abnormal_response_to2.83138121
8MP0003111_abnormal_nucleus_morphology2.63055766
9MP0008007_abnormal_cellular_replicative2.40810006
10MP0009785_altered_susceptibility_to2.38534430
11MP0005076_abnormal_cell_differentiation2.34431167
12MP0003077_abnormal_cell_cycle2.28967245
13MP0004808_abnormal_hematopoietic_stem2.24970941
14MP0003763_abnormal_thymus_physiology2.21596910
15MP0002877_abnormal_melanocyte_morpholog2.21504777
16MP0001800_abnormal_humoral_immune2.19175645
17MP0003705_abnormal_hypodermis_morpholog2.18327059
18MP0001730_embryonic_growth_arrest2.15593835
19MP0002148_abnormal_hypersensitivity_rea2.14299838
20MP0002398_abnormal_bone_marrow2.13588902
21MP0004147_increased_porphyrin_level2.06544182
22MP0000490_abnormal_crypts_of2.01848451
23MP0001545_abnormal_hematopoietic_system1.99173143
24MP0005397_hematopoietic_system_phenotyp1.99173143
25MP0002452_abnormal_antigen_presenting1.98375676
26MP0002420_abnormal_adaptive_immunity1.96691759
27MP0005000_abnormal_immune_tolerance1.94954574
28MP0001819_abnormal_immune_cell1.94066989
29MP0002723_abnormal_immune_serum1.93227130
30MP0003436_decreased_susceptibility_to1.91104994
31MP0005025_abnormal_response_to1.90624852
32MP0000685_abnormal_immune_system1.85688958
33MP0005464_abnormal_platelet_physiology1.85113152
34MP0002419_abnormal_innate_immunity1.84923423
35MP0003724_increased_susceptibility_to1.83961456
36MP0009278_abnormal_bone_marrow1.83521034
37MP0006292_abnormal_olfactory_placode1.81126269
38MP0005174_abnormal_tail_pigmentation1.78528204
39MP0000689_abnormal_spleen_morphology1.78062999
40MP0001672_abnormal_embryogenesis/_devel1.77828888
41MP0005380_embryogenesis_phenotype1.77828888
42MP0004233_abnormal_muscle_weight1.76128954
43MP0000716_abnormal_immune_system1.75900580
44MP0004957_abnormal_blastocyst_morpholog1.75668347
45* MP0001697_abnormal_embryo_size1.75082538
46MP0002722_abnormal_immune_system1.71678684
47MP0009333_abnormal_splenocyte_physiolog1.71563335
48MP0010030_abnormal_orbit_morphology1.67723877
49MP0002429_abnormal_blood_cell1.65751792
50MP0002405_respiratory_system_inflammati1.62665182
51MP0005387_immune_system_phenotype1.61031213
52MP0001790_abnormal_immune_system1.61031213
53MP0003806_abnormal_nucleotide_metabolis1.60020716
54MP0002080_prenatal_lethality1.59948122
55MP0000465_gastrointestinal_hemorrhage1.57687568
56MP0004185_abnormal_adipocyte_glucose1.57627728
57MP0003984_embryonic_growth_retardation1.55815019
58MP0002132_abnormal_respiratory_system1.54767010
59MP0000703_abnormal_thymus_morphology1.52722704
60MP0002006_tumorigenesis1.51485907
61MP0005451_abnormal_body_composition1.49827121
62MP0002088_abnormal_embryonic_growth/wei1.48291058
63MP0009053_abnormal_anal_canal1.47370077
64MP0010155_abnormal_intestine_physiology1.46635363
65MP0005501_abnormal_skin_physiology1.41385210
66MP0004264_abnormal_extraembryonic_tissu1.40292773
67MP0002009_preneoplasia1.39854528
68MP0001873_stomach_inflammation1.38787739
69MP0009672_abnormal_birth_weight1.38631015
70MP0002085_abnormal_embryonic_tissue1.38274588
71MP0005075_abnormal_melanosome_morpholog1.34178879
72MP0000015_abnormal_ear_pigmentation1.32411649
73MP0002277_abnormal_respiratory_mucosa1.32277284
74MP0002095_abnormal_skin_pigmentation1.27784059
75MP0008877_abnormal_DNA_methylation1.26956389
76MP0002166_altered_tumor_susceptibility1.26748922
77MP0002249_abnormal_larynx_morphology1.24695657
78MP0006082_CNS_inflammation1.23913120
79MP0002019_abnormal_tumor_incidence1.22372882
80MP0008260_abnormal_autophagy1.21378811
81MP0001188_hyperpigmentation1.19892644
82MP0003943_abnormal_hepatobiliary_system1.19383949
83MP0003656_abnormal_erythrocyte_physiolo1.18107923
84MP0003221_abnormal_cardiomyocyte_apopto1.18068277
85MP0003828_pulmonary_edema1.16852301
86MP0000358_abnormal_cell_content/1.15989823
87MP0004197_abnormal_fetal_growth/weight/1.15847303
88MP0001853_heart_inflammation1.15679151
89MP0002086_abnormal_extraembryonic_tissu1.14850950
90MP0002098_abnormal_vibrissa_morphology1.12907213
91MP0003786_premature_aging1.12850472
92MP0001845_abnormal_inflammatory_respons1.12787861
93MP0002084_abnormal_developmental_patter1.12546286
94MP0000858_altered_metastatic_potential1.11520257
95MP0006054_spinal_hemorrhage1.10894827
96MP0001346_abnormal_lacrimal_gland1.10834999
97MP0000313_abnormal_cell_death1.10095125
98MP0002092_abnormal_eye_morphology1.08897117
99MP0001293_anophthalmia1.04930932
100MP0002796_impaired_skin_barrier1.04810246
101MP0003121_genomic_imprinting1.04701043
102MP0005621_abnormal_cell_physiology1.04007668
103MP0009697_abnormal_copulation1.03594272
104MP0000350_abnormal_cell_proliferation1.03371905
105MP0001881_abnormal_mammary_gland1.01847979
106MP0000678_abnormal_parathyroid_gland1.01358964
107MP0001727_abnormal_embryo_implantation1.00288706
108MP0000627_abnormal_mammary_gland0.99107437
109MP0008932_abnormal_embryonic_tissue0.98924035
110MP0003315_abnormal_perineum_morphology0.98718010
111MP0005058_abnormal_lysosome_morphology0.98668011
112MP0000537_abnormal_urethra_morphology0.98241197
113MP0005384_cellular_phenotype0.97340119
114MP0001986_abnormal_taste_sensitivity0.94655360
115MP0002234_abnormal_pharynx_morphology0.94254468
116MP0003866_abnormal_defecation0.93190989
117MP0003890_abnormal_embryonic-extraembry0.91448566
118MP0006035_abnormal_mitochondrial_morpho0.90565604
119MP0001929_abnormal_gametogenesis0.88974853
120MP0002697_abnormal_eye_size0.88100402
121MP0001286_abnormal_eye_development0.87870304
122MP0005394_taste/olfaction_phenotype0.82722388
123MP0005499_abnormal_olfactory_system0.82722388
124MP0002160_abnormal_reproductive_system0.82459976
125MP0003787_abnormal_imprinting0.81693355
126MP0003699_abnormal_female_reproductive0.80696290
127MP0009764_decreased_sensitivity_to0.80375270
128MP0010307_abnormal_tumor_latency0.80010085
129MP0001533_abnormal_skeleton_physiology0.79637348
130MP0001119_abnormal_female_reproductive0.78700409
131MP0008469_abnormal_protein_level0.78115047
132MP0003448_altered_tumor_morphology0.77783636
133MP0005408_hypopigmentation0.76727813
134MP0005623_abnormal_meninges_morphology0.76221677
135MP0005310_abnormal_salivary_gland0.75618207
136MP0000428_abnormal_craniofacial_morphol0.75211215
137MP0003942_abnormal_urinary_system0.74530788
138MP0003186_abnormal_redox_activity0.73828690
139MP0009703_decreased_birth_body0.73655477
140MP0002177_abnormal_outer_ear0.72716790
141MP0005083_abnormal_biliary_tract0.72337889
142MP0002111_abnormal_tail_morphology0.72129687
143MP0001145_abnormal_male_reproductive0.71215160
144MP0000049_abnormal_middle_ear0.71058142
145MP0002163_abnormal_gland_morphology0.70287796
146MP0008789_abnormal_olfactory_epithelium0.69168415
147MP0005367_renal/urinary_system_phenotyp0.69060380
148MP0000516_abnormal_urinary_system0.69060380
149MP0002933_joint_inflammation0.67494776
150MP0002970_abnormal_white_adipose0.67223599
151MP0002210_abnormal_sex_determination0.65330383
152MP0000569_abnormal_digit_pigmentation0.63542271
153MP0003172_abnormal_lysosome_physiology0.62695919
154MP0009765_abnormal_xenobiotic_induced0.57715692
155MP0003941_abnormal_skin_development0.57584643
156MP0003718_maternal_effect0.56685503
157MP0002075_abnormal_coat/hair_pigmentati0.56545508
158MP0004947_skin_inflammation0.56326181
159MP0003183_abnormal_peptide_metabolism0.56317321
160MP0000371_diluted_coat_color0.56113348
161MP0010352_gastrointestinal_tract_polyps0.55928524
162MP0002938_white_spotting0.55521800
163MP0008995_early_reproductive_senescence0.55253148
164MP0000343_altered_response_to0.55153052
165MP0003303_peritoneal_inflammation0.54373631
166MP0009763_increased_sensitivity_to0.50884468

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.79016934
2Chromsome breakage (HP:0040012)4.72945675
3Microglossia (HP:0000171)4.02654613
4Birth length less than 3rd percentile (HP:0003561)3.54396188
5Myositis (HP:0100614)3.53414136
6Petechiae (HP:0000967)3.52383127
7Recurrent abscess formation (HP:0002722)3.35374588
8IgM deficiency (HP:0002850)3.26228396
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21020746
10Optic neuritis (HP:0100653)3.16034918
11Retrobulbar optic neuritis (HP:0100654)3.16034918
12Abnormality of chromosome stability (HP:0003220)3.03680846
13Prolonged bleeding time (HP:0003010)2.95537112
14Abnormality of the preputium (HP:0100587)2.95128396
15Septate vagina (HP:0001153)2.92597701
16Increased nuchal translucency (HP:0010880)2.92218608
17Meckel diverticulum (HP:0002245)2.86875056
18Orchitis (HP:0100796)2.86824789
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.82234180
20Abnormality of the ileum (HP:0001549)2.81919697
21Reticulocytopenia (HP:0001896)2.80466567
22Bone marrow hypocellularity (HP:0005528)2.78275506
23Cortical dysplasia (HP:0002539)2.78138036
24Abnormality of the fetal cardiovascular system (HP:0010948)2.77674662
25Abnormal umbilical cord blood vessels (HP:0011403)2.77674662
26Single umbilical artery (HP:0001195)2.77674662
27Abnormality of B cell number (HP:0010975)2.76739412
28B lymphocytopenia (HP:0010976)2.76739412
29Recurrent bacterial skin infections (HP:0005406)2.76732270
30Chronic otitis media (HP:0000389)2.76481754
31Reduced antithrombin III activity (HP:0001976)2.75544803
32Myelodysplasia (HP:0002863)2.71565408
33Hyperacusis (HP:0010780)2.71215015
34Type I transferrin isoform profile (HP:0003642)2.69997754
35Abnormality of the umbilical cord (HP:0010881)2.68398250
36Facial hemangioma (HP:0000329)2.67565157
37Recurrent fungal infections (HP:0002841)2.65048539
38Abnormality of the phalanges of the hallux (HP:0010057)2.63399316
39Abnormality of the prostate (HP:0008775)2.62941699
40Abnormality of the columella (HP:0009929)2.62334292
41Clubbing of toes (HP:0100760)2.61392533
42Volvulus (HP:0002580)2.60294571
43Progressive muscle weakness (HP:0003323)2.58624973
44Abnormal gallbladder physiology (HP:0012438)2.56310999
45Cholecystitis (HP:0001082)2.56310999
46Type 2 muscle fiber atrophy (HP:0003554)2.56237879
47Proximal placement of thumb (HP:0009623)2.56117945
48Recurrent viral infections (HP:0004429)2.56089540
49Panhypogammaglobulinemia (HP:0003139)2.54743737
50Duplicated collecting system (HP:0000081)2.54313477
51Reticulocytosis (HP:0001923)2.51556396
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.50193911
53Asymmetry of the thorax (HP:0001555)2.48236548
54Ectopic kidney (HP:0000086)2.48056723
55Eczematoid dermatitis (HP:0000976)2.46454091
56Aplastic anemia (HP:0001915)2.45600186
57Abnormality of the renal collecting system (HP:0004742)2.44628756
58Abnormality of reticulocytes (HP:0004312)2.44322336
59Chronic obstructive pulmonary disease (HP:0006510)2.43299456
60Obstructive lung disease (HP:0006536)2.43299456
61Premature graying of hair (HP:0002216)2.43098523
62Elevated erythrocyte sedimentation rate (HP:0003565)2.43082392
63Lymphoma (HP:0002665)2.42671903
64Abnormality of DNA repair (HP:0003254)2.42368029
65IgG deficiency (HP:0004315)2.41752256
66Meningitis (HP:0001287)2.39436394
67Deep philtrum (HP:0002002)2.38985551
68Deviation of the thumb (HP:0009603)2.38677171
69Abnormal protein glycosylation (HP:0012346)2.38274597
70Abnormal glycosylation (HP:0012345)2.38274597
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38274597
72Abnormal protein N-linked glycosylation (HP:0012347)2.38274597
73Thyroiditis (HP:0100646)2.38274074
74Medulloblastoma (HP:0002885)2.37052168
75Muscle fiber atrophy (HP:0100295)2.35786306
76Cutaneous melanoma (HP:0012056)2.35598020
77Thrombocytosis (HP:0001894)2.34511995
78Microvesicular hepatic steatosis (HP:0001414)2.32524329
79Nephroblastoma (Wilms tumor) (HP:0002667)2.31992129
80Syringomyelia (HP:0003396)2.30646289
81Spinal cord lesions (HP:0100561)2.30646289
82Duodenal stenosis (HP:0100867)2.29533323
83Small intestinal stenosis (HP:0012848)2.29533323
84Cafe-au-lait spot (HP:0000957)2.27685190
85Insomnia (HP:0100785)2.25627814
86Mediastinal lymphadenopathy (HP:0100721)2.22810631
87Abnormality of T cells (HP:0002843)2.22030654
88Acute myeloid leukemia (HP:0004808)2.21945228
89Arteriovenous malformation (HP:0100026)2.21483402
90Short thumb (HP:0009778)2.20686559
91Multiple enchondromatosis (HP:0005701)2.20315576
92Breast hypoplasia (HP:0003187)2.20138483
93Granulocytopenia (HP:0001913)2.19682262
94Abnormality of the fingertips (HP:0001211)2.14018003
95Abnormality of T cell physiology (HP:0011840)2.13959262
96Embryonal renal neoplasm (HP:0011794)2.12268572
97Severe combined immunodeficiency (HP:0004430)2.12128136
98Abnormality of glycolysis (HP:0004366)2.11959664
9911 pairs of ribs (HP:0000878)2.11517932
1003-Methylglutaconic aciduria (HP:0003535)2.11092252
101Recurrent pneumonia (HP:0006532)2.10991372
102Recurrent bronchitis (HP:0002837)2.09083829
103Keratoconjunctivitis sicca (HP:0001097)2.08847942
104Triphalangeal thumb (HP:0001199)2.08169385
105Patellar aplasia (HP:0006443)2.06141556
106Abnormal lung lobation (HP:0002101)2.05322119
107Overlapping toe (HP:0001845)2.05180367
108Abnormality of the carotid arteries (HP:0005344)2.03478141
109Choanal atresia (HP:0000453)2.02601142
110Abnormality of the distal phalanges of the toes (HP:0010182)2.01912115
111Prostate neoplasm (HP:0100787)2.00556457
112Acute lymphatic leukemia (HP:0006721)2.00484755
113Agammaglobulinemia (HP:0004432)1.99828811
114Entropion (HP:0000621)1.99178957
115Absent radius (HP:0003974)1.97206738
116Rough bone trabeculation (HP:0100670)1.97129956
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97086498
118Abnormality of the anterior horn cell (HP:0006802)1.97047771
119Degeneration of anterior horn cells (HP:0002398)1.97047771
120Ragged-red muscle fibers (HP:0003200)1.96869931
121Encephalitis (HP:0002383)1.96137718
122Selective tooth agenesis (HP:0001592)1.95502455
123Recurrent cutaneous fungal infections (HP:0011370)1.94713442
124Chronic mucocutaneous candidiasis (HP:0002728)1.94713442
125Eosinophilia (HP:0001880)1.94038200
126Secondary amenorrhea (HP:0000869)1.93777588
127Capillary hemangiomas (HP:0005306)1.92793563
128Facial cleft (HP:0002006)1.92520885
129Pancytopenia (HP:0001876)1.91726795
130Poikiloderma (HP:0001029)1.91712677
131Abnormal delayed hypersensitivity skin test (HP:0002963)1.91617041
132Hypoplasia of the thymus (HP:0000778)1.90962654
133Atresia of the external auditory canal (HP:0000413)1.90813344
134Increased serum pyruvate (HP:0003542)1.90796531
135Recurrent skin infections (HP:0001581)1.90707718
136T lymphocytopenia (HP:0005403)1.90036774
137Oral leukoplakia (HP:0002745)1.90005089
138Abnormalities of placenta or umbilical cord (HP:0001194)1.89347234
139Keratoconjunctivitis (HP:0001096)1.89229586
140Epistaxis (HP:0000421)1.89118890
141Orthostatic hypotension (HP:0001278)1.87593769
142Overriding aorta (HP:0002623)1.86797254
143Aplasia/Hypoplasia of the patella (HP:0006498)1.86199944
144Cellulitis (HP:0100658)1.85971821
145Short middle phalanx of the 5th finger (HP:0004220)1.85711143
146Abnormality of chromosome segregation (HP:0002916)1.85374526
147Abnormality of T cell number (HP:0011839)1.85292648
148Abnormality of eosinophils (HP:0001879)1.84787488
149Squamous cell carcinoma (HP:0002860)1.84650618
150Aseptic necrosis (HP:0010885)1.84564495
151Cleft eyelid (HP:0000625)1.83950165
152Leukocytosis (HP:0001974)1.82760635
153Abnormality of the duodenum (HP:0002246)1.81986094
154Chronic diarrhea (HP:0002028)1.81732945
155Hypoparathyroidism (HP:0000829)1.81472263
156Aplasia involving forearm bones (HP:0009822)1.81083559
157Absent forearm bone (HP:0003953)1.81083559
158Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80888933
159Leiomyosarcoma (HP:0100243)1.80793573
160Uterine leiomyosarcoma (HP:0002891)1.80793573
161Neutropenia (HP:0001875)1.80211468
162Leukopenia (HP:0001882)1.80203011
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.79223648
164High pitched voice (HP:0001620)1.75410083
165Patellar dislocation (HP:0002999)1.75248067
166High anterior hairline (HP:0009890)1.74992710
167Termporal pattern (HP:0011008)1.74446849
168Insidious onset (HP:0003587)1.74446849
169Absent thumb (HP:0009777)1.74205685
170Trismus (HP:0000211)1.73523906
171Premature ovarian failure (HP:0008209)1.73028144
172Abnormality of lateral ventricle (HP:0030047)1.71078300
173Abnormality of cells of the erythroid lineage (HP:0012130)1.70923657
174Abnormal number of incisors (HP:0011064)1.69405470
175Ependymoma (HP:0002888)1.69199053
176Cholelithiasis (HP:0001081)1.66726927
177Breast carcinoma (HP:0003002)1.65029428
178J-shaped sella turcica (HP:0002680)1.64623880
179Abnormal number of erythroid precursors (HP:0012131)1.64320036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK43.29779796
2IRAK42.76627182
3SCYL22.72533254
4SMG12.62338477
5STK162.54074146
6VRK22.50047060
7PBK2.38284602
8TXK2.37478315
9CDC72.35737509
10MAP4K12.34968611
11TRIB32.34220331
12SRPK12.32857977
13TEC2.18540960
14VRK12.10593012
15BLK2.06029761
16KIT1.95830801
17MKNK11.95371240
18IRAK31.87310332
19WEE11.85056465
20MKNK21.79855995
21ZAK1.76674495
22NME21.75685150
23BUB11.75282197
24BRD41.69609666
25TRIM281.65165688
26BTK1.64134729
27NEK11.60289809
28ATR1.56604549
29TAF11.51713059
30RPS6KA41.51351050
31EIF2AK11.49403996
32ERBB31.48167316
33BMPR21.43506657
34DYRK31.43005380
35MAP3K101.41296176
36ZAP701.38620903
37FLT31.37307292
38CLK11.36373714
39AURKA1.34440812
40JAK31.31328439
41STK41.30511167
42PIM11.28504469
43IKBKB1.26332061
44MAP3K141.23327404
45ICK1.18576698
46CSF1R1.17415173
47TLK11.17281443
48EIF2AK21.16984260
49IKBKE1.16841777
50MAP3K81.16805698
51SIK11.16640942
52CCNB11.16118767
53NEK21.14878066
54GRK11.13613511
55TESK21.13099370
56MAP2K31.13022303
57INSRR1.12896064
58SYK1.11717251
59STK101.10639702
60YES11.09506974
61CDK71.08998539
62BRSK21.08071124
63PASK1.05860213
64PRPF4B1.05685868
65MAP3K91.01914352
66EIF2AK31.01900427
67PIM21.01234485
68AURKB0.98934819
69CDK120.98257727
70ACVR1B0.98137250
71TGFBR20.96598049
72PLK10.94511172
73TSSK60.94415416
74CDK190.93466721
75LYN0.93383712
76SIK30.93302758
77KSR10.92247612
78ADRBK20.91542576
79TAOK20.89647337
80CHUK0.85836365
81TIE10.85692058
82CDK80.85569139
83RAF10.84790480
84ARAF0.84747671
85CDK40.84295857
86PKN20.84089034
87TBK10.83044003
88MAP3K120.82214725
89TYK20.80371094
90NLK0.78480114
91EPHA20.78175204
92EEF2K0.78163100
93CHEK20.75682048
94RPS6KB20.74642215
95TTK0.74616935
96PLK30.72964131
97ITK0.72800337
98LCK0.71143089
99BRAF0.69854986
100CDK90.68844169
101MELK0.68326810
102TAOK30.68273939
103MTOR0.66350205
104CDK20.65686876
105CDK10.63213969
106KSR20.62834844
107DMPK0.61815920
108KDR0.59866715
109NUAK10.59790292
110TRPM70.59714408
111NEK90.59338455
112MAPKAPK50.59218848
113CHEK10.58307425
114MUSK0.58274954
115MAP3K60.57369648
116ATM0.57107872
117TNK20.56950426
118HCK0.56303909
119PRKCI0.54856047
120PRKD30.53301962
121CDK180.53205225
122TESK10.53166797
123ILK0.53098436
124STK30.51834047
125RPS6KA50.51771984
126NME10.50950976
127BRSK10.49235820
128CDK60.49216699
129CDK150.48808314
130IRAK20.47648267
131CDK11A0.47002652
132CSNK2A10.45783088
133CDK140.45548368
134STK240.45141661
135CAMK1D0.45006964
136AKT20.44088762
137TGFBR10.43279643
138CDK30.42525904
139MAP2K60.41850276
140PAK40.39411250
141CSNK2A20.39128547
142MAPKAPK20.39061546
143NEK60.39025540
144CSNK1G30.38497385
145PAK10.37867252
146LRRK20.37089862
147DAPK10.36900294
148RPS6KB10.36294158
149MAP2K20.35353450
150CAMK1G0.34610674
151MAPKAPK30.32382787

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.93958918
2Homologous recombination_Homo sapiens_hsa034403.10748494
3Mismatch repair_Homo sapiens_hsa034302.78488988
4Base excision repair_Homo sapiens_hsa034102.64158203
5Non-homologous end-joining_Homo sapiens_hsa034502.61718745
6Fanconi anemia pathway_Homo sapiens_hsa034602.46443686
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.43831382
8RNA polymerase_Homo sapiens_hsa030202.39075148
9Cell cycle_Homo sapiens_hsa041102.17736455
10Primary immunodeficiency_Homo sapiens_hsa053402.10728446
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03433649
12Spliceosome_Homo sapiens_hsa030401.96027309
13Pyrimidine metabolism_Homo sapiens_hsa002401.91936455
14Nucleotide excision repair_Homo sapiens_hsa034201.86741008
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.84071668
16One carbon pool by folate_Homo sapiens_hsa006701.83841786
17Ribosome_Homo sapiens_hsa030101.82860408
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74164801
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.70357237
20Leishmaniasis_Homo sapiens_hsa051401.70166071
21Measles_Homo sapiens_hsa051621.67573320
22RNA transport_Homo sapiens_hsa030131.64918615
23Herpes simplex infection_Homo sapiens_hsa051681.63755485
24Hematopoietic cell lineage_Homo sapiens_hsa046401.63419442
25RNA degradation_Homo sapiens_hsa030181.63386386
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58650416
27Allograft rejection_Homo sapiens_hsa053301.47962896
28Bladder cancer_Homo sapiens_hsa052191.43884687
29Basal transcription factors_Homo sapiens_hsa030221.43569447
30Thyroid cancer_Homo sapiens_hsa052161.39331262
31p53 signaling pathway_Homo sapiens_hsa041151.36555963
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36417268
33Graft-versus-host disease_Homo sapiens_hsa053321.30695615
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29622002
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28669022
36Proteasome_Homo sapiens_hsa030501.28427561
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26162325
38Biosynthesis of amino acids_Homo sapiens_hsa012301.22991222
39Legionellosis_Homo sapiens_hsa051341.19447708
40Purine metabolism_Homo sapiens_hsa002301.17103412
41Antigen processing and presentation_Homo sapiens_hsa046121.14120179
42Epstein-Barr virus infection_Homo sapiens_hsa051691.12478792
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.11439368
44Sulfur relay system_Homo sapiens_hsa041221.06765847
45Non-small cell lung cancer_Homo sapiens_hsa052231.05512983
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05256418
47Systemic lupus erythematosus_Homo sapiens_hsa053221.03575751
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.00931137
49Influenza A_Homo sapiens_hsa051641.00543635
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99705342
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98068855
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97658352
53Osteoclast differentiation_Homo sapiens_hsa043800.97246356
54Oocyte meiosis_Homo sapiens_hsa041140.97014979
55Malaria_Homo sapiens_hsa051440.96832130
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.95034625
57B cell receptor signaling pathway_Homo sapiens_hsa046620.94846628
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92221596
59Hepatitis B_Homo sapiens_hsa051610.91378598
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88895258
61Apoptosis_Homo sapiens_hsa042100.86152462
62Folate biosynthesis_Homo sapiens_hsa007900.85282052
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84726716
64mRNA surveillance pathway_Homo sapiens_hsa030150.84552365
65Pertussis_Homo sapiens_hsa051330.83899303
66Viral carcinogenesis_Homo sapiens_hsa052030.83304395
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83133939
68Asthma_Homo sapiens_hsa053100.82422587
69Carbon metabolism_Homo sapiens_hsa012000.81918767
70Other glycan degradation_Homo sapiens_hsa005110.80654985
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79788042
72Steroid biosynthesis_Homo sapiens_hsa001000.77938073
73HTLV-I infection_Homo sapiens_hsa051660.77262521
74TNF signaling pathway_Homo sapiens_hsa046680.77045440
75Autoimmune thyroid disease_Homo sapiens_hsa053200.77025299
76Protein export_Homo sapiens_hsa030600.76175108
77Prostate cancer_Homo sapiens_hsa052150.74456288
78T cell receptor signaling pathway_Homo sapiens_hsa046600.74305985
79N-Glycan biosynthesis_Homo sapiens_hsa005100.74074123
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.72496823
81Acute myeloid leukemia_Homo sapiens_hsa052210.72428772
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70552900
83Fatty acid elongation_Homo sapiens_hsa000620.70325435
84Type I diabetes mellitus_Homo sapiens_hsa049400.68960324
85Shigellosis_Homo sapiens_hsa051310.68420635
86Endometrial cancer_Homo sapiens_hsa052130.67084112
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65343741
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64035815
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63218165
90Renal cell carcinoma_Homo sapiens_hsa052110.62009310
91Tuberculosis_Homo sapiens_hsa051520.61472626
92Chronic myeloid leukemia_Homo sapiens_hsa052200.61168535
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60607989
94Pyruvate metabolism_Homo sapiens_hsa006200.60563622
95Vitamin B6 metabolism_Homo sapiens_hsa007500.60213579
96Glioma_Homo sapiens_hsa052140.60033171
97Toxoplasmosis_Homo sapiens_hsa051450.57775420
98Small cell lung cancer_Homo sapiens_hsa052220.57105137
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56686497
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56456452
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55167233
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54660977
103Melanoma_Homo sapiens_hsa052180.54513611
104Fructose and mannose metabolism_Homo sapiens_hsa000510.53705267
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52807122
106Rheumatoid arthritis_Homo sapiens_hsa053230.51146325
107Chemokine signaling pathway_Homo sapiens_hsa040620.51091443
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50521375
109mTOR signaling pathway_Homo sapiens_hsa041500.50490701
110TGF-beta signaling pathway_Homo sapiens_hsa043500.49914606
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49775767
112MicroRNAs in cancer_Homo sapiens_hsa052060.49652722
113Salmonella infection_Homo sapiens_hsa051320.48482950
114Platelet activation_Homo sapiens_hsa046110.48412132
115Pentose phosphate pathway_Homo sapiens_hsa000300.47607106
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47514924
117Glutathione metabolism_Homo sapiens_hsa004800.47025031
118Hepatitis C_Homo sapiens_hsa051600.46775071
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.45580888
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45217824
121Pancreatic cancer_Homo sapiens_hsa052120.45213290
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44569120
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43454784
124ErbB signaling pathway_Homo sapiens_hsa040120.42156175
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41464767
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40442800
127Notch signaling pathway_Homo sapiens_hsa043300.39305240
128Viral myocarditis_Homo sapiens_hsa054160.39152903
129Alcoholism_Homo sapiens_hsa050340.38971450
130Vibrio cholerae infection_Homo sapiens_hsa051100.38039614
131Galactose metabolism_Homo sapiens_hsa000520.36510356
132Lysine degradation_Homo sapiens_hsa003100.35947677
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35572857
134Selenocompound metabolism_Homo sapiens_hsa004500.34356297
135FoxO signaling pathway_Homo sapiens_hsa040680.34337309
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33841276
137Arachidonic acid metabolism_Homo sapiens_hsa005900.33753931
138Staphylococcus aureus infection_Homo sapiens_hsa051500.33381096
139Huntingtons disease_Homo sapiens_hsa050160.33246612
140African trypanosomiasis_Homo sapiens_hsa051430.30460265
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.29760804
142Colorectal cancer_Homo sapiens_hsa052100.29229195
143Proteoglycans in cancer_Homo sapiens_hsa052050.28229507
144Insulin signaling pathway_Homo sapiens_hsa049100.27801240
145HIF-1 signaling pathway_Homo sapiens_hsa040660.27676906
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.27547574
147Wnt signaling pathway_Homo sapiens_hsa043100.24694181
148AMPK signaling pathway_Homo sapiens_hsa041520.23166110
149Adherens junction_Homo sapiens_hsa045200.22883016

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