DCN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)7.94786945
2protein heterotrimerization (GO:0070208)7.68483028
3negative regulation of complement activation (GO:0045916)6.22238533
4* peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.74204053
5type B pancreatic cell proliferation (GO:0044342)5.56916958
6opsonization (GO:0008228)5.50122887
7collagen fibril organization (GO:0030199)5.45305732
8cell migration involved in heart development (GO:0060973)5.37386684
9negative regulation of protein activation cascade (GO:2000258)5.30752083
10extracellular fibril organization (GO:0043206)5.23823076
11bone trabecula formation (GO:0060346)5.03528026
12mesenchymal-epithelial cell signaling (GO:0060638)5.01197465
13positive regulation of fatty acid oxidation (GO:0046321)4.56549867
14blood vessel maturation (GO:0001955)4.51948470
15lymph vessel development (GO:0001945)4.38915783
16fibril organization (GO:0097435)4.37058610
17glomerular basement membrane development (GO:0032836)4.25884960
18regulation of complement activation (GO:0030449)4.23799254
19glomerulus development (GO:0032835)4.22697284
20positive regulation of respiratory burst (GO:0060267)4.15526271
21sequestering of extracellular ligand from receptor (GO:0035581)4.14690379
22collagen metabolic process (GO:0032963)4.08632008
23mesenchymal cell differentiation involved in kidney development (GO:0072161)4.07390147
24mesenchymal cell differentiation involved in renal system development (GO:2001012)4.07390147
25collagen catabolic process (GO:0030574)4.05877449
26complement activation, alternative pathway (GO:0006957)4.05233249
27negative regulation of chondrocyte differentiation (GO:0032331)3.99586156
28regulation of protein activation cascade (GO:2000257)3.95658032
29negative regulation of humoral immune response (GO:0002921)3.95114885
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.92010547
31peripheral nervous system axon ensheathment (GO:0032292)3.91319945
32myelination in peripheral nervous system (GO:0022011)3.91319945
33multicellular organismal macromolecule metabolic process (GO:0044259)3.89534395
34basement membrane organization (GO:0071711)3.89336399
35positive regulation of glycogen biosynthetic process (GO:0045725)3.88857710
36cell differentiation involved in metanephros development (GO:0072202)3.86562580
37cellular response to cadmium ion (GO:0071276)3.83014899
38positive regulation of macrophage cytokine production (GO:0060907)3.81196296
39adhesion of symbiont to host cell (GO:0044650)3.79757574
40virion attachment to host cell (GO:0019062)3.79757574
41multicellular organismal catabolic process (GO:0044243)3.78292876
42multicellular organismal metabolic process (GO:0044236)3.73768509
43retina vasculature morphogenesis in camera-type eye (GO:0061299)3.67087492
44regulation of macrophage cytokine production (GO:0010935)3.66279511
45positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.55427297
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.51609960
47negative regulation of protein autophosphorylation (GO:0031953)3.51488868
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49796915
49endodermal cell differentiation (GO:0035987)3.46755164
50detection of molecule of bacterial origin (GO:0032490)3.40833399
51cell proliferation involved in metanephros development (GO:0072203)3.39549086
52negative regulation of cartilage development (GO:0061037)3.38433946
53positive regulation of endothelial cell apoptotic process (GO:2000353)3.35603511
54negative regulation of smooth muscle cell migration (GO:0014912)3.33192964
55positive regulation of glycogen metabolic process (GO:0070875)3.30795319
56* sulfur compound catabolic process (GO:0044273)3.29326374
57keratan sulfate biosynthetic process (GO:0018146)3.28072379
58pathway-restricted SMAD protein phosphorylation (GO:0060389)3.26069052
59face morphogenesis (GO:0060325)3.23790321
60middle ear morphogenesis (GO:0042474)3.23423184
61homocysteine metabolic process (GO:0050667)3.22663768
62adhesion of symbiont to host (GO:0044406)3.22061543
63* extracellular matrix disassembly (GO:0022617)3.21479751
64regulation of response to osmotic stress (GO:0047484)3.19845299
65venous blood vessel morphogenesis (GO:0048845)3.19738198
66protein localization to cell surface (GO:0034394)3.19098235
67regulation of integrin-mediated signaling pathway (GO:2001044)3.18363277
68trabecula formation (GO:0060343)3.17626278
69keratan sulfate metabolic process (GO:0042339)3.16743620
70respiratory tube development (GO:0030323)3.16246172
71negative regulation of cardiac muscle tissue growth (GO:0055022)3.16042622
72negative regulation of heart growth (GO:0061117)3.16042622
73* dermatan sulfate biosynthetic process (GO:0030208)3.14504566
74barbed-end actin filament capping (GO:0051016)3.14308472
75* extracellular matrix organization (GO:0030198)3.10656885
76* extracellular structure organization (GO:0043062)3.09293764
77protein retention in ER lumen (GO:0006621)3.08416989
78regulation of extracellular matrix disassembly (GO:0010715)3.08289281
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07954293
80diaphragm development (GO:0060539)3.04803982
81extracellular matrix assembly (GO:0085029)3.04771734
82endothelial cell proliferation (GO:0001935)3.02307287
83surfactant homeostasis (GO:0043129)3.01499225
84regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.00775673
85endocardial cushion development (GO:0003197)3.00725573
86extracellular regulation of signal transduction (GO:1900115)3.00219076
87extracellular negative regulation of signal transduction (GO:1900116)3.00219076
88positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.99926845
89atrioventricular valve morphogenesis (GO:0003181)2.98846253
90gonadal mesoderm development (GO:0007506)2.97669100
91protein trimerization (GO:0070206)2.95928163
92response to follicle-stimulating hormone (GO:0032354)2.95631024
93tooth mineralization (GO:0034505)2.95000928
94fibroblast migration (GO:0010761)2.94001494
95negative regulation of leukocyte chemotaxis (GO:0002689)2.91846226
96cell proliferation involved in kidney development (GO:0072111)2.91189641
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90024718
98ovulation from ovarian follicle (GO:0001542)2.87660715
99regulation of SMAD protein import into nucleus (GO:0060390)2.86626143
100* dermatan sulfate metabolic process (GO:0030205)2.83713713
101vasculature development (GO:0001944)2.83310328
102positive regulation of mesenchymal cell proliferation (GO:0002053)2.82614642
103positive regulation of fatty acid metabolic process (GO:0045923)2.82388994
104negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81141436
105* glycosaminoglycan catabolic process (GO:0006027)2.80213166
106endocardial cushion morphogenesis (GO:0003203)2.79542472
107regulation of fatty acid oxidation (GO:0046320)2.78566324
108lung vasculature development (GO:0060426)2.77885737
109positive regulation of smooth muscle cell migration (GO:0014911)2.75986629
110regulation of smooth muscle cell migration (GO:0014910)2.73780178
111regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.73631305
112cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.72584570
113negative regulation of androgen receptor signaling pathway (GO:0060766)2.71963472
114cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71370787
115chondrocyte proliferation (GO:0035988)2.70891077
116endothelial cell morphogenesis (GO:0001886)2.70828600
117glomerular filtration (GO:0003094)2.70417982
118skeletal muscle organ development (GO:0060538)2.69558286
119positive regulation of gastrulation (GO:2000543)2.68580571
120embryonic cranial skeleton morphogenesis (GO:0048701)2.66016143
121regulation of cardiac muscle hypertrophy (GO:0010611)2.65886816
122skin morphogenesis (GO:0043589)2.65139220
123iron ion import (GO:0097286)2.64718269
124organ induction (GO:0001759)2.62357010
125neuron projection extension involved in neuron projection guidance (GO:1902284)2.62284202
126axon extension involved in axon guidance (GO:0048846)2.62284202
127regulation of cardiac muscle cell differentiation (GO:2000725)2.62041245
128mesenchyme morphogenesis (GO:0072132)2.61416186
129regulation of mesenchymal cell proliferation (GO:0010464)2.61295530
130metanephric mesenchyme development (GO:0072075)2.59911179
131* aminoglycan catabolic process (GO:0006026)2.59125464
132cellular response to vitamin (GO:0071295)2.59087105
133kidney mesenchyme development (GO:0072074)2.58733782
134regulation of glycogen biosynthetic process (GO:0005979)2.58692281
135regulation of glucan biosynthetic process (GO:0010962)2.58692281
136cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.58505730
137regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.56967506
138outer ear morphogenesis (GO:0042473)2.55941190
139nucleoside diphosphate catabolic process (GO:0009134)2.55908648
140smooth muscle tissue development (GO:0048745)2.55833937
141regulation of muscle hypertrophy (GO:0014743)2.55520612
142regulation of plasminogen activation (GO:0010755)2.54620355
143negative regulation of osteoblast proliferation (GO:0033689)2.52209104
144apoptotic cell clearance (GO:0043277)2.51266999
145cellular response to amino acid stimulus (GO:0071230)2.51060164
146positive regulation of fibroblast migration (GO:0010763)2.49883749
147pericardium development (GO:0060039)2.49793163
148oxygen transport (GO:0015671)2.49703587
149positive regulation of glucose import (GO:0046326)2.49627655
150cardiac myofibril assembly (GO:0055003)2.48425382
151vascular endothelial growth factor signaling pathway (GO:0038084)2.47209029
152fibrinolysis (GO:0042730)2.46636420
153lung lobe morphogenesis (GO:0060463)2.46042772
154negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)2.43919811
155import into cell (GO:0098657)2.42122330
156negative regulation of BMP signaling pathway (GO:0030514)2.41646560
157positive regulation of p38MAPK cascade (GO:1900745)2.41350829
158negative regulation of glycogen biosynthetic process (GO:0045719)2.40260882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.15539781
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.68982782
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.36103864
4CLOCK_20551151_ChIP-Seq_293T_Human3.11043956
5* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.99938352
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.48613868
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.48261691
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.37654975
9* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.34581354
10CJUN_26792858_Chip-Seq_BT549_Human2.34219802
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.29934750
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.12640602
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10062105
14GATA1_22025678_ChIP-Seq_K562_Human2.05609471
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04003232
16* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.03195999
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92724909
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.89963848
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.89535405
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.82283778
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76902444
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73027275
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.71122968
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.70250061
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65504252
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.65272106
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64652403
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64652403
29* AR_21572438_ChIP-Seq_LNCaP_Human1.63404460
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.62858802
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60858186
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59996278
33* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56760472
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54895834
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54284438
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52931581
37* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52931581
38* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42660372
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39181938
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37975069
41SOX2_20726797_ChIP-Seq_SW620_Human1.36642749
42SA1_22415368_ChIP-Seq_MEFs_Mouse1.36482180
43TP53_16413492_ChIP-PET_HCT116_Human1.34020688
44TP53_18474530_ChIP-ChIP_U2OS_Human1.32175155
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31902209
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31713773
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.30998932
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30166486
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.28679872
50BRD4_25478319_ChIP-Seq_HGPS_Human1.27595796
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27370028
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25376856
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24905604
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22114632
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20993063
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20835977
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17639536
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17263718
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16428259
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.16151584
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15380369
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.14395813
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13462260
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.12097065
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.12097065
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.12013480
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10839579
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10778236
69DROSHA_22980978_ChIP-Seq_HELA_Human1.10690883
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07218229
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06740971
72AHR_22903824_ChIP-Seq_MCF-7_Human1.06534262
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05490487
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04380076
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.01534275
76* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00088758
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97588091
78WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96096129
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95624627
80HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95498224
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95049500
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94370036
83SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93292575
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92108867
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91792274
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91489836
87TP53_23651856_ChIP-Seq_MEFs_Mouse0.91122095
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.90487691
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90446127
90* BCAT_22108803_ChIP-Seq_LS180_Human0.90136067
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89305456
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.88377494
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87536188
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87536188
95* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86521305
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85879047
97MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85795062
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.85198361
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84722263
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84695830
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84353969
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.83576718
103GBX2_23144817_ChIP-Seq_PC3_Human0.83330556
104TP63_23658742_ChIP-Seq_EP156T_Human0.83087726
105* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82721195
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82425457
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82376509
108SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82056022
109TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81928018
110TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81404675
111EZH2_27294783_Chip-Seq_ESCs_Mouse0.81093782
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.81037562
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80029030
114JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79963203
115FOXA2_19822575_ChIP-Seq_HepG2_Human0.78843035
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.78174483
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78046077
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78029181
119CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76737305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen8.63143881
2* MP0005503_abnormal_tendon_morphology7.35012446
3* MP0005275_abnormal_skin_tensile6.67898662
4MP0001958_emphysema3.60884636
5MP0004272_abnormal_basement_membrane3.25192542
6MP0003279_aneurysm2.47357800
7MP0006054_spinal_hemorrhage2.47070298
8MP0000751_myopathy2.44806299
9* MP0002108_abnormal_muscle_morphology2.37200188
10* MP0005508_abnormal_skeleton_morphology2.30258246
11MP0003705_abnormal_hypodermis_morpholog2.23470360
12MP0010368_abnormal_lymphatic_system2.21387429
13MP0003195_calcinosis2.10530367
14* MP0002060_abnormal_skin_morphology2.07059126
15MP0005023_abnormal_wound_healing1.86271355
16MP0001879_abnormal_lymphatic_vessel1.84582274
17MP0003252_abnormal_bile_duct1.68766495
18MP0002933_joint_inflammation1.66979884
19MP0000003_abnormal_adipose_tissue1.66441962
20MP0001542_abnormal_bone_strength1.55348657
21MP0001661_extended_life_span1.55037003
22MP0002295_abnormal_pulmonary_circulatio1.48312033
23MP0003566_abnormal_cell_adhesion1.43484030
24MP0005257_abnormal_intraocular_pressure1.37786468
25MP0000767_abnormal_smooth_muscle1.37621969
26MP0009780_abnormal_chondrocyte_physiolo1.35999555
27MP0001299_abnormal_eye_distance/1.35510872
28* MP0005390_skeleton_phenotype1.32933203
29MP0003115_abnormal_respiratory_system1.30198835
30MP0002998_abnormal_bone_remodeling1.30150292
31MP0002089_abnormal_postnatal_growth/wei1.24374683
32MP0002282_abnormal_trachea_morphology1.22344990
33MP0000534_abnormal_ureter_morphology1.20980865
34* MP0001243_abnormal_dermal_layer1.18940896
35MP0000163_abnormal_cartilage_morphology1.15796270
36MP0009250_abnormal_appendicular_skeleto1.14530803
37MP0010030_abnormal_orbit_morphology1.11010095
38MP0000749_muscle_degeneration1.10620458
39MP0002249_abnormal_larynx_morphology1.10104457
40MP0002896_abnormal_bone_mineralization1.09065213
41MP0002837_dystrophic_cardiac_calcinosis1.06768651
42MP0003941_abnormal_skin_development1.02528656
43MP0001533_abnormal_skeleton_physiology1.01712761
44MP0000013_abnormal_adipose_tissue1.00396525
45MP0005171_absent_coat_pigmentation0.99282802
46MP0002115_abnormal_skeleton_extremities0.99160633
47MP0000343_altered_response_to0.99004555
48MP0005375_adipose_tissue_phenotype0.97638988
49MP0004883_abnormal_blood_vessel0.96743369
50MP0000681_abnormal_thyroid_gland0.95589850
51MP0005164_abnormal_response_to0.95196648
52* MP0005369_muscle_phenotype0.92643885
53MP0003385_abnormal_body_wall0.91934085
54MP0005595_abnormal_vascular_smooth0.91207157
55MP0000750_abnormal_muscle_regeneration0.90522577
56MP0004484_altered_response_of0.89936088
57MP0000733_abnormal_muscle_development0.89448905
58MP0009384_cardiac_valve_regurgitation0.88758294
59MP0005330_cardiomyopathy0.88104492
60MP0001175_abnormal_lung_morphology0.87255395
61MP0002254_reproductive_system_inflammat0.86904965
62MP0008004_abnormal_stomach_pH0.85975714
63MP0002133_abnormal_respiratory_system0.85277154
64MP0005388_respiratory_system_phenotype0.85277154
65MP0002168_other_aberrant_phenotype0.83273795
66MP0003283_abnormal_digestive_organ0.81871206
67MP0003795_abnormal_bone_structure0.80888903
68MP0002113_abnormal_skeleton_development0.80409883
69MP0002009_preneoplasia0.79562659
70MP0005165_increased_susceptibility_to0.78351348
71MP0004036_abnormal_muscle_relaxation0.76051371
72MP0005670_abnormal_white_adipose0.75474000
73MP0004858_abnormal_nervous_system0.74966196
74MP0003075_altered_response_to0.74690608
75MP0003448_altered_tumor_morphology0.73612189
76MP0002166_altered_tumor_susceptibility0.72579866
77MP0000249_abnormal_blood_vessel0.71291812
78MP0002932_abnormal_joint_morphology0.70645663
79MP0003045_fibrosis0.69480618
80MP0002128_abnormal_blood_circulation0.68839075
81MP0001348_abnormal_lacrimal_gland0.68640349
82MP0003724_increased_susceptibility_to0.68618471
83MP0001544_abnormal_cardiovascular_syste0.68169945
84MP0005385_cardiovascular_system_phenoty0.68169945
85MP0005623_abnormal_meninges_morphology0.67959432
86MP0005620_abnormal_muscle_contractility0.67861042
87MP0000747_muscle_weakness0.67377299
88MP0003942_abnormal_urinary_system0.67281239
89MP0000762_abnormal_tongue_morphology0.66516677
90MP0000462_abnormal_digestive_system0.66500095
91MP0006138_congestive_heart_failure0.65239331
92MP0003011_delayed_dark_adaptation0.64643129
93MP0010386_abnormal_urinary_bladder0.63442384
94MP0000759_abnormal_skeletal_muscle0.63252556
95MP0000428_abnormal_craniofacial_morphol0.61850650
96MP0004087_abnormal_muscle_fiber0.61650887
97MP0004145_abnormal_muscle_electrophysio0.61022096
98MP0000049_abnormal_middle_ear0.60824914
99MP0003191_abnormal_cellular_cholesterol0.59975564
100MP0004134_abnormal_chest_morphology0.59671321
101MP0003300_gastrointestinal_ulcer0.59370004
102MP0000538_abnormal_urinary_bladder0.58940357
103MP0001849_ear_inflammation0.58033381
104MP0001614_abnormal_blood_vessel0.57667279
105MP0003950_abnormal_plasma_membrane0.57560119
106MP0001177_atelectasis0.57074945
107MP0000230_abnormal_systemic_arterial0.56295066
108MP0005197_abnormal_uvea_morphology0.55849410
109MP0003646_muscle_fatigue0.55684717
110MP0003091_abnormal_cell_migration0.55295712
111* MP0010771_integument_phenotype0.55139232
112MP0010352_gastrointestinal_tract_polyps0.54601781
113MP0005084_abnormal_gallbladder_morpholo0.54557105
114MP0002116_abnormal_craniofacial_bone0.54540766
115MP0002127_abnormal_cardiovascular_syste0.54230682
116MP0000604_amyloidosis0.54014683
117MP0004084_abnormal_cardiac_muscle0.53984869
118* MP0000432_abnormal_head_morphology0.53794808
119MP0008775_abnormal_heart_ventricle0.53619708
120MP0001270_distended_abdomen0.53578129
121MP0002114_abnormal_axial_skeleton0.51156089
122MP0002971_abnormal_brown_adipose0.51048400
123MP0003938_abnormal_ear_development0.50196080

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.06628691
2Broad metatarsal (HP:0001783)7.23425294
3Ankle contracture (HP:0006466)6.16196482
4Premature rupture of membranes (HP:0001788)5.85639056
5Wrist flexion contracture (HP:0001239)5.73328688
6Cervical subluxation (HP:0003308)5.44165354
7Aortic dissection (HP:0002647)5.02233653
8Aortic aneurysm (HP:0004942)4.23421016
9Follicular hyperkeratosis (HP:0007502)4.18279327
10Shallow orbits (HP:0000586)4.07144307
11Round ear (HP:0100830)3.99687060
12Mitral stenosis (HP:0001718)3.95951530
13Cerebral aneurysm (HP:0004944)3.89590842
14Type 1 muscle fiber predominance (HP:0003803)3.80400838
15Soft skin (HP:0000977)3.66828482
16Vertebral compression fractures (HP:0002953)3.54888925
17Systemic lupus erythematosus (HP:0002725)3.47642175
18Neonatal short-limb short stature (HP:0008921)3.33482919
19Spinal rigidity (HP:0003306)3.29158186
20Dilatation of the ascending aorta (HP:0005111)3.28875029
21Myocardial infarction (HP:0001658)3.21349295
22Mitral valve prolapse (HP:0001634)3.17744212
23Coronal craniosynostosis (HP:0004440)3.15924913
24Complement deficiency (HP:0004431)3.14732277
25Peritonitis (HP:0002586)3.03820539
26Spondylolisthesis (HP:0003302)3.01665619
27Overgrowth (HP:0001548)3.01618884
28Increased connective tissue (HP:0009025)2.99941483
29Pulmonary artery stenosis (HP:0004415)2.99728161
30Bladder diverticulum (HP:0000015)2.92310135
31Blue sclerae (HP:0000592)2.87697361
32Delayed closure of the anterior fontanelle (HP:0001476)2.80917367
33Hip contracture (HP:0003273)2.79179094
34Aortic regurgitation (HP:0001659)2.77690129
35Aortic valve stenosis (HP:0001650)2.76348729
36Thin bony cortex (HP:0002753)2.74185375
37Slender build (HP:0001533)2.73120434
38Vascular tortuosity (HP:0004948)2.71832131
39Atrophic scars (HP:0001075)2.69165873
40Cardiovascular calcification (HP:0011915)2.68742075
41Bowel diverticulosis (HP:0005222)2.68248590
42Osteolytic defects of the hand bones (HP:0009699)2.66656217
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.66656217
44Fragile skin (HP:0001030)2.60390690
45Persistence of primary teeth (HP:0006335)2.56366331
46Wormian bones (HP:0002645)2.53171786
47Abnormal delivery (HP:0001787)2.50852857
48Abnormality of complement system (HP:0005339)2.47727598
49Striae distensae (HP:0001065)2.45309884
50J-shaped sella turcica (HP:0002680)2.44811962
51Arterial tortuosity (HP:0005116)2.43402915
52Increased variability in muscle fiber diameter (HP:0003557)2.43213892
53Alopecia of scalp (HP:0002293)2.42013611
54Disproportionate tall stature (HP:0001519)2.40716601
55Right ventricular cardiomyopathy (HP:0011663)2.39586802
56Glomerulonephritis (HP:0000099)2.39516608
57Abnormality of the acetabulum (HP:0003170)2.37099931
58Camptodactyly of toe (HP:0001836)2.36704850
59Hyperextensible skin (HP:0000974)2.35295927
60Amyloidosis (HP:0011034)2.34832410
61Emphysema (HP:0002097)2.33818575
62Biconcave vertebral bodies (HP:0004586)2.33124785
63Narrow nasal bridge (HP:0000446)2.31161008
64Ovoid vertebral bodies (HP:0003300)2.30246409
65Tarsal synostosis (HP:0008368)2.28510590
66Limited hip movement (HP:0008800)2.28079877
67Joint stiffness (HP:0001387)2.26081787
68Joint laxity (HP:0001388)2.24837608
69Abnormality of molar morphology (HP:0011070)2.23647853
70Abnormality of molar (HP:0011077)2.23647853
71Bell-shaped thorax (HP:0001591)2.23585996
72Skin nodule (HP:0200036)2.22978680
73Wide anterior fontanel (HP:0000260)2.22167660
74Rectal prolapse (HP:0002035)2.20919719
75Aneurysm (HP:0002617)2.19314567
76Mildly elevated creatine phosphokinase (HP:0008180)2.16500388
77Generalized amyotrophy (HP:0003700)2.16074058
78Breech presentation (HP:0001623)2.15230961
79Short hallux (HP:0010109)2.13825024
80Abnormality of skeletal muscle fiber size (HP:0012084)2.09943656
81Hypoventilation (HP:0002791)2.09376205
82Mesomelia (HP:0003027)2.06961031
83Hypophosphatemic rickets (HP:0004912)2.06191717
84Flat cornea (HP:0007720)2.04262130
85Mild short stature (HP:0003502)2.00459332
86Synostosis involving bones of the feet (HP:0009140)2.00108363
87Synostosis involving bones of the lower limbs (HP:0009138)2.00108363
88Nephritis (HP:0000123)1.97977058
89Genu recurvatum (HP:0002816)1.97416980
90Hypoplasia of the iris (HP:0007676)1.97303296
91Redundant skin (HP:0001582)1.96935182
92Osteoarthritis (HP:0002758)1.93415727
93Muscle fiber splitting (HP:0003555)1.92749820
94Protruding ear (HP:0000411)1.92650702
95Osteopenia (HP:0000938)1.91937910
96Flared iliac wings (HP:0002869)1.91209633
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90330186
98Lipoatrophy (HP:0100578)1.90300343
99Coxa vara (HP:0002812)1.89462992
100Asymmetric septal hypertrophy (HP:0001670)1.89107780
101Beaking of vertebral bodies (HP:0004568)1.88231916
102Long toe (HP:0010511)1.88147212
103Increased corneal curvature (HP:0100692)1.87085546
104Keratoconus (HP:0000563)1.87085546
105Gingival overgrowth (HP:0000212)1.86908050
106Joint contractures involving the joints of the feet (HP:0100492)1.86784169
107Flexion contracture of toe (HP:0005830)1.86784169
108Aplasia/Hypoplasia of the hallux (HP:0008362)1.86607870
109Mitral regurgitation (HP:0001653)1.86317859
110Turricephaly (HP:0000262)1.85580062
111Absent frontal sinuses (HP:0002688)1.84999131
112Ectopia lentis (HP:0001083)1.83507967
113Delayed cranial suture closure (HP:0000270)1.83173329
114Broad ribs (HP:0000885)1.83094105
115Deformed sella turcica (HP:0002681)1.82332308
116Abnormality of dentin (HP:0010299)1.80512742
117Subacute progressive viral hepatitis (HP:0006572)1.79928378
118Venous abnormality (HP:0002624)1.79684314
119Bulbar palsy (HP:0001283)1.77444922
120Abnormality of the calf musculature (HP:0001430)1.76784124
121Abnormality of skull ossification (HP:0002703)1.75254174
122Natal tooth (HP:0000695)1.75056052
123Inguinal hernia (HP:0000023)1.74871115
124* Corneal dystrophy (HP:0001131)1.74763109
125Vascular calcification (HP:0004934)1.74722215
126Calf muscle hypertrophy (HP:0008981)1.73175822
127Elbow flexion contracture (HP:0002987)1.73148212
128Nonimmune hydrops fetalis (HP:0001790)1.70277397
129Venous insufficiency (HP:0005293)1.68832933
130Thoracolumbar scoliosis (HP:0002944)1.67775303
131Infantile muscular hypotonia (HP:0008947)1.65536198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.34901860
2PDGFRA3.73354358
3MYLK3.43038893
4GRK53.41493088
5INSRR3.33437797
6TTN3.09302933
7GRK13.04065603
8DDR22.86006513
9ADRBK22.59740808
10FER2.36812514
11EPHB22.32521805
12ERBB32.27196024
13TRPM72.25135418
14LATS12.20219891
15STK38L2.16778867
16AKT32.02818744
17KIT1.99650520
18TNK21.99434497
19GRK61.97852980
20EPHA31.88500632
21SIK11.78919607
22MST1R1.76573630
23ADRBK11.76177263
24ERN11.73601396
25DMPK1.72774240
26MET1.62759548
27MAP2K71.59789201
28GRK71.56276786
29BCKDK1.55611875
30LATS21.53655792
31TRIB31.53009287
32PRKD21.51498480
33TIE11.42110540
34ABL21.39912808
35ZAK1.35352224
36PAK21.33238712
37STK241.32287531
38CAMK1G1.27656555
39CSK1.24142002
40CAMK1D1.23327745
41LIMK11.22863891
42RIPK11.22766164
43STK31.19653536
44PTK61.19256544
45EPHB11.13771784
46PDGFRB1.12808563
47PRKCH1.08364840
48LMTK21.07402061
49PINK11.06568073
50JAK11.04610196
51NTRK11.03197305
52BMPR21.03063812
53FRK1.02046980
54FGFR41.01367106
55FLT30.97736734
56JAK30.93765498
57NEK90.92858091
58NLK0.91372654
59ROCK10.88785549
60PDK20.86091171
61OBSCN0.84515226
62MAP2K20.83189669
63PIK3CA0.82595698
64ILK0.82244651
65MAPKAPK30.80813750
66GSK3A0.80726051
67MAP3K70.80510600
68RPS6KA20.79996956
69NEK60.77222750
70PIK3CG0.76638998
71BMX0.76591567
72MAPK150.71531755
73PTK20.70130097
74EEF2K0.69457753
75ZAP700.67755189
76PHKG10.67092006
77PHKG20.67092006
78WNK10.65235275
79PAK40.64852967
80PTK2B0.63193045
81FGFR30.62225938
82MAP3K30.61121819
83PRKD10.60217491
84ROCK20.58981224
85STK380.58464869
86TESK10.55638658
87PLK20.55063198
88PRKCE0.54101692
89PRKD30.51988040
90MARK20.51655253
91MTOR0.51054629
92PIM20.51000054
93SGK30.50536131
94RPS6KC10.50276164
95RPS6KL10.50276164
96MAP3K60.47919026
97MAP2K10.47333088
98PRKAA20.47111073
99MOS0.46861514
100TGFBR10.46791555
101MELK0.46772678
102CAMK2G0.46313429
103TYK20.45111137
104TBK10.44297478
105DAPK20.43046093
106IGF1R0.42736492
107MAPK70.42230437
108DAPK30.41630710
109HIPK20.41615711
110FGFR20.41149751
111PAK30.40929967
112CLK10.39660437
113ERBB40.39348947
114MAPK120.39187623
115MAPKAPK20.39109225
116RPS6KA60.38428769
117PRKG10.37946690
118NUAK10.37686009
119PDK30.37340901
120PDK40.37340901
121SGK20.37165870
122ABL10.37000494
123CDC42BPA0.36755746
124JAK20.36612019
125IRAK10.35522428
126CAMK40.35242780
127FGFR10.35068977
128MAPK40.34776229
129MAPK30.33942255
130CAMK10.32419519
131PRKG20.32206167
132PRKCD0.29954309
133INSR0.29239146
134PKN20.29051516
135KSR20.28387391
136RET0.27560217
137PDPK10.27092155
138PRPF4B0.26924461

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.63711053
2Complement and coagulation cascades_Homo sapiens_hsa046102.36081740
3Focal adhesion_Homo sapiens_hsa045102.33487212
4Protein digestion and absorption_Homo sapiens_hsa049742.23202707
5Amoebiasis_Homo sapiens_hsa051462.06712470
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.04178041
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.94780096
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90445334
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.80600176
10Staphylococcus aureus infection_Homo sapiens_hsa051501.78330488
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77435629
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75877993
13Starch and sucrose metabolism_Homo sapiens_hsa005001.74310923
14Dilated cardiomyopathy_Homo sapiens_hsa054141.72593188
15PPAR signaling pathway_Homo sapiens_hsa033201.65993146
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62728105
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62009343
18Malaria_Homo sapiens_hsa051441.58715955
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51541917
20Fatty acid degradation_Homo sapiens_hsa000711.41361921
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35530100
22* TGF-beta signaling pathway_Homo sapiens_hsa043501.29773331
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.28750991
24Nitrogen metabolism_Homo sapiens_hsa009101.28222000
25Viral myocarditis_Homo sapiens_hsa054161.24757515
26Arachidonic acid metabolism_Homo sapiens_hsa005901.23624195
27* Proteoglycans in cancer_Homo sapiens_hsa052051.23455521
28Fatty acid metabolism_Homo sapiens_hsa012121.21190559
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14587948
30Propanoate metabolism_Homo sapiens_hsa006401.11719037
31Adherens junction_Homo sapiens_hsa045201.11190728
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10603558
33Caffeine metabolism_Homo sapiens_hsa002321.10569245
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08414697
35Mineral absorption_Homo sapiens_hsa049781.07272791
36Prion diseases_Homo sapiens_hsa050201.06781966
37Small cell lung cancer_Homo sapiens_hsa052221.05919776
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03881405
39Chemical carcinogenesis_Homo sapiens_hsa052041.00429539
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.00255043
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98211723
42Tryptophan metabolism_Homo sapiens_hsa003800.96457480
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95504215
44Renin-angiotensin system_Homo sapiens_hsa046140.94895620
45Gap junction_Homo sapiens_hsa045400.94672955
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93447866
47beta-Alanine metabolism_Homo sapiens_hsa004100.93089872
48Melanogenesis_Homo sapiens_hsa049160.92125548
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89302227
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88282913
51Bladder cancer_Homo sapiens_hsa052190.88118086
52Rap1 signaling pathway_Homo sapiens_hsa040150.86799406
53Insulin resistance_Homo sapiens_hsa049310.86374917
54Lysine degradation_Homo sapiens_hsa003100.85236000
55Ovarian steroidogenesis_Homo sapiens_hsa049130.84878887
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84776425
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.84174027
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83839521
59Pathways in cancer_Homo sapiens_hsa052000.83581219
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82926847
61mTOR signaling pathway_Homo sapiens_hsa041500.82745699
62Toxoplasmosis_Homo sapiens_hsa051450.82335848
63Glutathione metabolism_Homo sapiens_hsa004800.82096809
64Prostate cancer_Homo sapiens_hsa052150.80998017
65Thyroid hormone synthesis_Homo sapiens_hsa049180.80179206
66Histidine metabolism_Homo sapiens_hsa003400.77745528
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.77511741
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76803777
69Pertussis_Homo sapiens_hsa051330.72082888
70Galactose metabolism_Homo sapiens_hsa000520.71711005
71Chronic myeloid leukemia_Homo sapiens_hsa052200.71515840
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.70881824
73TNF signaling pathway_Homo sapiens_hsa046680.70295785
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.69859162
75Calcium signaling pathway_Homo sapiens_hsa040200.68276344
76Fatty acid elongation_Homo sapiens_hsa000620.67999018
77Retinol metabolism_Homo sapiens_hsa008300.67131668
78Fatty acid biosynthesis_Homo sapiens_hsa000610.66955914
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66195277
80Axon guidance_Homo sapiens_hsa043600.65747750
81AMPK signaling pathway_Homo sapiens_hsa041520.65529505
82Phenylalanine metabolism_Homo sapiens_hsa003600.65271488
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64373350
84ABC transporters_Homo sapiens_hsa020100.61249232
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61107755
86Hippo signaling pathway_Homo sapiens_hsa043900.60260677
87Basal cell carcinoma_Homo sapiens_hsa052170.59953679
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59760657
89Wnt signaling pathway_Homo sapiens_hsa043100.58471380
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58330261
91Phagosome_Homo sapiens_hsa041450.58019399
92Arginine and proline metabolism_Homo sapiens_hsa003300.57524400
93Other glycan degradation_Homo sapiens_hsa005110.57044862
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56703812
95Tight junction_Homo sapiens_hsa045300.54937115
96MAPK signaling pathway_Homo sapiens_hsa040100.54885280
97Estrogen signaling pathway_Homo sapiens_hsa049150.54586946
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54550601
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53323472
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52883842
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52843944
102Endocytosis_Homo sapiens_hsa041440.50860025
103Glioma_Homo sapiens_hsa052140.50337863
104Lysosome_Homo sapiens_hsa041420.49217212
105Renal cell carcinoma_Homo sapiens_hsa052110.47785196
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47522360
107Circadian rhythm_Homo sapiens_hsa047100.47328379
108Melanoma_Homo sapiens_hsa052180.47014121
109Cocaine addiction_Homo sapiens_hsa050300.46864359
110Tyrosine metabolism_Homo sapiens_hsa003500.46347264
111Sulfur metabolism_Homo sapiens_hsa009200.45931299
112Ras signaling pathway_Homo sapiens_hsa040140.45758268
113GnRH signaling pathway_Homo sapiens_hsa049120.45566515
114Choline metabolism in cancer_Homo sapiens_hsa052310.45447237
115Fat digestion and absorption_Homo sapiens_hsa049750.45342586
116Osteoclast differentiation_Homo sapiens_hsa043800.45258550
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.45035279
118Hedgehog signaling pathway_Homo sapiens_hsa043400.44796747
119Oxytocin signaling pathway_Homo sapiens_hsa049210.44031024
120FoxO signaling pathway_Homo sapiens_hsa040680.43021852
121Arginine biosynthesis_Homo sapiens_hsa002200.42961140
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42838028
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42613974
124MicroRNAs in cancer_Homo sapiens_hsa052060.42108989
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40785095
126Bile secretion_Homo sapiens_hsa049760.40358824
127Pancreatic cancer_Homo sapiens_hsa052120.40203702
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40081036
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.39298239
130Renin secretion_Homo sapiens_hsa049240.38151182
131Vitamin digestion and absorption_Homo sapiens_hsa049770.37753854
132Butanoate metabolism_Homo sapiens_hsa006500.36024517
133Platelet activation_Homo sapiens_hsa046110.35724472
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34352101

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