DCP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)6.38357516
2cilium or flagellum-dependent cell motility (GO:0001539)5.35860419
3axonemal dynein complex assembly (GO:0070286)5.30606201
4sperm motility (GO:0030317)5.13867983
5epithelial cilium movement (GO:0003351)4.98561403
6motile cilium assembly (GO:0044458)4.75935042
7cilium movement (GO:0003341)4.73578826
8acrosome reaction (GO:0007340)4.65841178
9rRNA modification (GO:0000154)4.64299915
10chaperone-mediated protein transport (GO:0072321)4.57830282
11acrosome assembly (GO:0001675)4.51836986
12respiratory chain complex IV assembly (GO:0008535)4.49071612
13fusion of sperm to egg plasma membrane (GO:0007342)4.43828719
14protein deneddylation (GO:0000338)4.43157140
15axon ensheathment in central nervous system (GO:0032291)4.34236836
16central nervous system myelination (GO:0022010)4.34236836
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.23693616
18cytochrome complex assembly (GO:0017004)4.13421881
19rRNA methylation (GO:0031167)4.13185991
20protein complex biogenesis (GO:0070271)4.07613362
21cell wall macromolecule metabolic process (GO:0044036)4.00060010
22cell wall macromolecule catabolic process (GO:0016998)4.00060010
23regulation of microtubule-based movement (GO:0060632)3.92823664
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88290971
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.88290971
26NADH dehydrogenase complex assembly (GO:0010257)3.88290971
27transcription from mitochondrial promoter (GO:0006390)3.83897708
28sperm-egg recognition (GO:0035036)3.83725281
29mitochondrial respiratory chain complex assembly (GO:0033108)3.81684034
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77689949
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77689949
32DNA double-strand break processing (GO:0000729)3.76737041
33cullin deneddylation (GO:0010388)3.76395110
34multicellular organism reproduction (GO:0032504)3.71954646
35proteasome assembly (GO:0043248)3.69764074
36ribosomal small subunit assembly (GO:0000028)3.66142471
37platelet dense granule organization (GO:0060155)3.64858426
38spermatid development (GO:0007286)3.64112026
39DNA damage response, detection of DNA damage (GO:0042769)3.63136454
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61800352
41ventricular system development (GO:0021591)3.60793716
42regulation of mitochondrial translation (GO:0070129)3.58472758
43cell-cell recognition (GO:0009988)3.52738851
44intraciliary transport (GO:0042073)3.50780502
45base-excision repair, AP site formation (GO:0006285)3.50370969
46plasma membrane fusion (GO:0045026)3.49511698
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46176410
48iron-sulfur cluster assembly (GO:0016226)3.45184450
49metallo-sulfur cluster assembly (GO:0031163)3.45184450
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40619645
51protein neddylation (GO:0045116)3.39994685
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39801336
53protein-DNA complex disassembly (GO:0032986)3.36879754
54nucleosome disassembly (GO:0006337)3.36879754
55pyrimidine dimer repair (GO:0006290)3.36728498
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34351863
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34351863
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34351863
59branched-chain amino acid catabolic process (GO:0009083)3.33478242
60nonmotile primary cilium assembly (GO:0035058)3.32146371
61dendritic spine morphogenesis (GO:0060997)3.31757511
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31630404
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31630404
64negative regulation of inclusion body assembly (GO:0090084)3.29878088
65negative regulation of ligase activity (GO:0051352)3.27585742
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27585742
67CENP-A containing nucleosome assembly (GO:0034080)3.27004056
68histone H3-K4 trimethylation (GO:0080182)3.25727400
69sperm capacitation (GO:0048240)3.24323926
70ribosome assembly (GO:0042255)3.22812170
71striatum development (GO:0021756)3.22550730
72mannosylation (GO:0097502)3.21968950
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.19247811
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19247811
75binding of sperm to zona pellucida (GO:0007339)3.19031670
76chromatin remodeling at centromere (GO:0031055)3.18953919
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.17970300
78IMP biosynthetic process (GO:0006188)3.16489258
79* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16156857
80ubiquinone biosynthetic process (GO:0006744)3.15104550
81ubiquinone metabolic process (GO:0006743)3.14895157
82nerve growth factor signaling pathway (GO:0038180)3.14825191
83* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14802315
84deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.13452468
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13257164
86microtubule severing (GO:0051013)3.13065411
87histone H2A acetylation (GO:0043968)3.12534227
88establishment of integrated proviral latency (GO:0075713)3.10515432
89negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.08952483
90water-soluble vitamin biosynthetic process (GO:0042364)3.08574645
91regulation of helicase activity (GO:0051095)3.07065544
92growth hormone secretion (GO:0030252)3.06745110
93protein localization to cilium (GO:0061512)3.05447522
94positive T cell selection (GO:0043368)3.05050599
95ribosomal large subunit biogenesis (GO:0042273)3.02872082
96DNA catabolic process, exonucleolytic (GO:0000738)3.02824014
97regulation of cellular amino acid metabolic process (GO:0006521)3.00301482
98peptidyl-arginine omega-N-methylation (GO:0035247)2.99488478
99DNA ligation (GO:0006266)2.98852078
100histone mRNA metabolic process (GO:0008334)2.97996613
101microtubule depolymerization (GO:0007019)2.97596235
102establishment of protein localization to mitochondrial membrane (GO:0090151)2.97513897
103substrate-independent telencephalic tangential migration (GO:0021826)2.96544805
104substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96544805
105reproduction (GO:0000003)2.92062219
106purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.91397668
107purine deoxyribonucleotide catabolic process (GO:0009155)2.91084733
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90559027
109spliceosomal snRNP assembly (GO:0000387)2.90326708
110piRNA metabolic process (GO:0034587)2.88606939
111pteridine-containing compound biosynthetic process (GO:0042559)2.88367123
112membrane depolarization during action potential (GO:0086010)2.88305015
113positive regulation of mitochondrial fission (GO:0090141)2.87998205
114pseudouridine synthesis (GO:0001522)2.87864146
115regulation of memory T cell differentiation (GO:0043380)2.86465945
116activated T cell proliferation (GO:0050798)2.85598786
117male meiosis (GO:0007140)2.84136693
118regulation of mitotic spindle checkpoint (GO:1903504)2.84126272
119regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84126272
120histone exchange (GO:0043486)2.84045108
121inner mitochondrial membrane organization (GO:0007007)2.83485197
122left/right axis specification (GO:0070986)2.82730457
123protein polyglutamylation (GO:0018095)2.82526090
124response to pheromone (GO:0019236)2.82375435
125DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82282160
126DNA integration (GO:0015074)2.82043633
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81699667
128negative regulation of cell killing (GO:0031342)2.81699667
129detection of calcium ion (GO:0005513)2.80556860
130phosphorelay signal transduction system (GO:0000160)2.80038055
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78514244
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.78514244
133intracellular protein transmembrane import (GO:0044743)2.78318885
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77473149
135negative regulation of gene expression, epigenetic (GO:0045814)2.76584118
136histone mRNA catabolic process (GO:0071044)2.76004915
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75792473
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75570348
139neuron cell-cell adhesion (GO:0007158)2.75492367
140cellular response to interleukin-15 (GO:0071350)2.74736717
141termination of RNA polymerase III transcription (GO:0006386)2.73445447
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.73445447
143regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.73234546
144venous blood vessel morphogenesis (GO:0048845)2.72473565
145positive regulation of ligase activity (GO:0051351)2.71727624
146cilium morphogenesis (GO:0060271)2.70683093
147protein K11-linked ubiquitination (GO:0070979)2.70620230
148deoxyribonucleotide catabolic process (GO:0009264)2.70449726
149negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.70022345
150axoneme assembly (GO:0035082)2.68873544
151mitochondrial RNA metabolic process (GO:0000959)2.67914950
152negative regulation by host of viral transcription (GO:0043922)2.67583857
153preassembly of GPI anchor in ER membrane (GO:0016254)2.66992814
154neuron recognition (GO:0008038)2.66229488
155spermatid nucleus differentiation (GO:0007289)2.65807577
156lactate metabolic process (GO:0006089)2.65762982
157cell recognition (GO:0008037)2.64834576
158calcium ion-dependent exocytosis (GO:0017156)2.64152057
159deoxyribose phosphate catabolic process (GO:0046386)2.64088002
160histone H3-K9 methylation (GO:0051567)2.63279199
161protein targeting to mitochondrion (GO:0006626)2.62521004
162single fertilization (GO:0007338)2.61648776
163cilium assembly (GO:0042384)2.58552879
164axonal fasciculation (GO:0007413)2.57869491
165spermatogenesis (GO:0007283)2.56695671
166cilium organization (GO:0044782)2.55958742
167male gamete generation (GO:0048232)2.55326693
168central nervous system projection neuron axonogenesis (GO:0021952)2.51529552
169calcium ion import (GO:0070509)2.49642402
170ionotropic glutamate receptor signaling pathway (GO:0035235)2.49137333
171RNA localization (GO:0006403)2.42235041
172negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38355645
173negative regulation of organelle assembly (GO:1902116)2.37898274
174forebrain neuron differentiation (GO:0021879)2.35897590
175positive regulation of synaptic transmission, GABAergic (GO:0032230)2.35723933
176left/right pattern formation (GO:0060972)2.35673919
177regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35343581
178synaptonemal complex organization (GO:0070193)2.35267442
179regulation of Rap GTPase activity (GO:0032317)2.34398073
180gamete generation (GO:0007276)2.33515770
181retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33450517
182lymphoid progenitor cell differentiation (GO:0002320)2.33227307
183germ cell development (GO:0007281)2.32166397
184single strand break repair (GO:0000012)2.31770322
185positive regulation of Rap GTPase activity (GO:0032854)2.29439087
186regulation of synapse assembly (GO:0051963)2.27421727
187cellular component assembly involved in morphogenesis (GO:0010927)2.27245113
188mRNA splice site selection (GO:0006376)2.26475409
189regulation of response to food (GO:0032095)2.25750670
190presynaptic membrane organization (GO:0097090)2.25363163
191positive regulation of synapse assembly (GO:0051965)2.24887639
192regulation of respiratory system process (GO:0044065)2.24863913
193fertilization (GO:0009566)2.24123524
194peptidyl-lysine trimethylation (GO:0018023)2.23576881
195histone H3-K9 modification (GO:0061647)2.23135576
196positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.22998084
197ribosomal small subunit biogenesis (GO:0042274)2.22840949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.76237614
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.15682995
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.10652806
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.97423823
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.85035025
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41563076
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.24622578
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.16215488
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16183567
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14026010
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10604575
12VDR_23849224_ChIP-Seq_CD4+_Human3.04092437
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.99794139
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94725753
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90917914
16FOXP3_21729870_ChIP-Seq_TREG_Human2.89233767
17ELK1_19687146_ChIP-ChIP_HELA_Human2.73485744
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70010120
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67956927
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59933054
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59134896
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.47713580
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.41516802
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40781713
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38262671
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35654692
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25157883
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25100564
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21504890
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15282078
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07331502
32DCP1A_22483619_ChIP-Seq_HELA_Human2.06631239
33GABP_19822575_ChIP-Seq_HepG2_Human2.05291679
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02662390
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02592153
36HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01115821
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00625567
38DROSHA_22980978_ChIP-Seq_HELA_Human1.95057071
39REST_21632747_ChIP-Seq_MESCs_Mouse1.94973962
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93311475
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86683919
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86246635
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84778826
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84007593
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80797561
46ZNF274_21170338_ChIP-Seq_K562_Hela1.80419396
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.78409877
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78279898
49XRN2_22483619_ChIP-Seq_HELA_Human1.77430876
50MYC_18940864_ChIP-ChIP_HL60_Human1.76218337
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.76176044
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75490105
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.74500565
54KDM5A_27292631_Chip-Seq_BREAST_Human1.72570940
55GBX2_23144817_ChIP-Seq_PC3_Human1.72353633
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71905408
57* TTF2_22483619_ChIP-Seq_HELA_Human1.69994283
58FUS_26573619_Chip-Seq_HEK293_Human1.65972112
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63363325
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.62196674
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.61907156
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55478954
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55267402
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.54953937
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54078209
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53973301
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52287065
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51806982
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50557052
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48937118
71SCL_19346495_ChIP-Seq_HPC-7_Human1.48350056
72RNF2_27304074_Chip-Seq_NSC_Mouse1.48315893
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48190007
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47602264
75EWS_26573619_Chip-Seq_HEK293_Human1.47099675
76* REST_18959480_ChIP-ChIP_MESCs_Mouse1.46133484
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46042221
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.45414144
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42259920
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40112843
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38268080
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38048843
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37230311
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.36797746
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36753382
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35540051
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34917600
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34689966
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34219467
90* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32916772
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32887325
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30654768
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30654768
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30402051
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26575315
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.26324469
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24550039
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23160707
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23160707
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22988845
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22444750
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22330399
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19081228
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18767049
105IGF1R_20145208_ChIP-Seq_DFB_Human1.16073155
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.15289760
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14966325
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14870502
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14845342
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14771479
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12368422
112* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12189370
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.11960684
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10397522
115* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10307456
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09560862
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09308463
118CIITA_25753668_ChIP-Seq_RAJI_Human1.08689565
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07691992
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05865432
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05322480
122E2F7_22180533_ChIP-Seq_HELA_Human1.05280124
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05107330
124CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03764234
125SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03416037
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03198807
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02963724
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02390326
129TFEB_21752829_ChIP-Seq_HELA_Human1.02179199
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.01987289
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01808094
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01298010
133TP53_22573176_ChIP-Seq_HFKS_Human1.01085562
134CBP_20019798_ChIP-Seq_JUKART_Human1.00978303
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00978303
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00964701
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00439858
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.98598688
139RUNX_20019798_ChIP-Seq_JUKART_Human0.98262061
140AR_21572438_ChIP-Seq_LNCaP_Human0.97548241
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97413105
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.96953876
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96892995
144SOX9_26525672_Chip-Seq_HEART_Mouse0.96542427
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.95539166
146ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95117118
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95014913
148EED_16625203_ChIP-ChIP_MESCs_Mouse0.94438044
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94418509
150* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94376298
151LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93136084
152IRF1_19129219_ChIP-ChIP_H3396_Human0.92979954
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92812364
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92724918
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92606678
156TCF4_23295773_ChIP-Seq_U87_Human0.91760084
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91427410
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90337783
159RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89567930
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89218619
161P300_19829295_ChIP-Seq_ESCs_Human0.89166952
162* E2F1_21310950_ChIP-Seq_MCF-7_Human0.88514346
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.87379009
164KDM2B_26808549_Chip-Seq_REH_Human0.86396490
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86305329
166TP63_19390658_ChIP-ChIP_HaCaT_Human0.86189906
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85958998
168* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85161063
169* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83794438
170GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83486497
171TAF15_26573619_Chip-Seq_HEK293_Human0.83399516
172GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83107147
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82517567
174P53_22387025_ChIP-Seq_ESCs_Mouse0.81141712
175SALL1_21062744_ChIP-ChIP_HESCs_Human0.81127887
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.81087601
177TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80897598
178* STAT3_23295773_ChIP-Seq_U87_Human0.80761293
179FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80748852
180SMAD3_21741376_ChIP-Seq_EPCs_Human0.80711957
181RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79979920
182* ELK1_22589737_ChIP-Seq_MCF10A_Human0.79602495
183POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79598209
184* SMAD4_21799915_ChIP-Seq_A2780_Human0.79307613
185FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78953332
186GF1_26923725_Chip-Seq_HPCs_Mouse0.78713731
187VDR_21846776_ChIP-Seq_THP-1_Human0.78685868
188SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78512581
189HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76047226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.64296249
2MP0003880_abnormal_central_pattern3.90154674
3MP0005423_abnormal_somatic_nervous3.19551228
4MP0003693_abnormal_embryo_hatching2.99920925
5MP0001529_abnormal_vocalization2.62455280
6MP0008877_abnormal_DNA_methylation2.57695342
7MP0008932_abnormal_embryonic_tissue2.50092562
8MP0003122_maternal_imprinting2.47460521
9MP0008007_abnormal_cellular_replicative2.37788887
10MP0003941_abnormal_skin_development2.36418647
11MP0003787_abnormal_imprinting2.35521293
12MP0003111_abnormal_nucleus_morphology2.28540853
13MP0001984_abnormal_olfaction2.23757153
14MP0005645_abnormal_hypothalamus_physiol2.23589423
15MP0003698_abnormal_male_reproductive2.22013283
16MP0004859_abnormal_synaptic_plasticity2.21868313
17MP0004957_abnormal_blastocyst_morpholog2.17516970
18MP0003567_abnormal_fetal_cardiomyocyte2.11348270
19MP0009697_abnormal_copulation2.07635879
20MP0003786_premature_aging2.07063959
21MP0010094_abnormal_chromosome_stability1.97364037
22MP0003077_abnormal_cell_cycle1.93844046
23MP0005646_abnormal_pituitary_gland1.93743945
24MP0005084_abnormal_gallbladder_morpholo1.93428237
25MP0004270_analgesia1.87718811
26MP0003635_abnormal_synaptic_transmissio1.86793536
27MP0001486_abnormal_startle_reflex1.83880707
28MP0003121_genomic_imprinting1.82867217
29MP0001293_anophthalmia1.80829183
30MP0000372_irregular_coat_pigmentation1.79822426
31MP0001929_abnormal_gametogenesis1.72622320
32MP0003718_maternal_effect1.72223734
33MP0003186_abnormal_redox_activity1.68688769
34MP0000631_abnormal_neuroendocrine_gland1.67047897
35MP0000778_abnormal_nervous_system1.63039730
36MP0005174_abnormal_tail_pigmentation1.62895829
37MP0002572_abnormal_emotion/affect_behav1.61926003
38MP0006035_abnormal_mitochondrial_morpho1.59878208
39MP0001485_abnormal_pinna_reflex1.57564438
40MP0002064_seizures1.57479527
41MP0005409_darkened_coat_color1.53909968
42MP0004510_myositis1.53634577
43MP0005075_abnormal_melanosome_morpholog1.53309175
44MP0009046_muscle_twitch1.52736332
45MP0002063_abnormal_learning/memory/cond1.50815428
46MP0005220_abnormal_exocrine_pancreas1.49688106
47MP0009745_abnormal_behavioral_response1.48444936
48MP0002938_white_spotting1.46554075
49MP0002653_abnormal_ependyma_morphology1.45253244
50MP0002272_abnormal_nervous_system1.44382500
51MP0009379_abnormal_foot_pigmentation1.43469898
52MP0001661_extended_life_span1.42572143
53MP0001727_abnormal_embryo_implantation1.42531669
54MP0008995_early_reproductive_senescence1.42201125
55MP0001188_hyperpigmentation1.42102608
56MP0001986_abnormal_taste_sensitivity1.41328323
57MP0004147_increased_porphyrin_level1.40510928
58MP0003123_paternal_imprinting1.39806723
59MP0000015_abnormal_ear_pigmentation1.39791983
60MP0008569_lethality_at_weaning1.38974744
61MP0006072_abnormal_retinal_apoptosis1.38705057
62MP0003763_abnormal_thymus_physiology1.38177218
63MP0002557_abnormal_social/conspecific_i1.37920604
64MP0002132_abnormal_respiratory_system1.37097965
65MP0000013_abnormal_adipose_tissue1.36857377
66MP0006276_abnormal_autonomic_nervous1.36557384
67MP0001502_abnormal_circadian_rhythm1.29548095
68MP0002638_abnormal_pupillary_reflex1.28350936
69MP0005551_abnormal_eye_electrophysiolog1.24527338
70MP0002254_reproductive_system_inflammat1.24173620
71MP0004145_abnormal_muscle_electrophysio1.23954826
72MP0008057_abnormal_DNA_replication1.22578328
73MP0005367_renal/urinary_system_phenotyp1.22244359
74MP0000516_abnormal_urinary_system1.22244359
75MP0004742_abnormal_vestibular_system1.21040903
76MP0005499_abnormal_olfactory_system1.20286890
77MP0005394_taste/olfaction_phenotype1.20286890
78MP0002233_abnormal_nose_morphology1.19695230
79MP0001968_abnormal_touch/_nociception1.19589844
80MP0002734_abnormal_mechanical_nocicepti1.19363787
81MP0006036_abnormal_mitochondrial_physio1.18529439
82MP0002160_abnormal_reproductive_system1.16802995
83MP0002210_abnormal_sex_determination1.15880466
84MP0008058_abnormal_DNA_repair1.14618444
85MP0002095_abnormal_skin_pigmentation1.14615117
86MP0000537_abnormal_urethra_morphology1.14476560
87MP0002184_abnormal_innervation1.13754632
88MP0002882_abnormal_neuron_morphology1.10800682
89MP0001119_abnormal_female_reproductive1.10539932
90MP0004142_abnormal_muscle_tone1.10242023
91MP0004811_abnormal_neuron_physiology1.09655004
92MP0002067_abnormal_sensory_capabilities1.09372383
93MP0010368_abnormal_lymphatic_system1.09158685
94MP0005389_reproductive_system_phenotype1.08237502
95MP0000358_abnormal_cell_content/1.05357695
96MP0002161_abnormal_fertility/fecundity1.04738722
97MP0000653_abnormal_sex_gland1.04656530
98MP0005253_abnormal_eye_physiology1.04643298
99MP0002736_abnormal_nociception_after1.04546258
100MP0008789_abnormal_olfactory_epithelium1.03865765
101MP0004381_abnormal_hair_follicle1.02939474
102MP0001905_abnormal_dopamine_level1.01415867
103MP0002152_abnormal_brain_morphology1.00365041
104MP0000313_abnormal_cell_death1.00161340
105MP0002127_abnormal_cardiovascular_syste0.97822644
106MP0003137_abnormal_impulse_conducting0.97779707
107MP0006292_abnormal_olfactory_placode0.97163277
108MP0002139_abnormal_hepatobiliary_system0.96970258
109MP0000751_myopathy0.96955406
110MP0002822_catalepsy0.94687420
111MP0003861_abnormal_nervous_system0.93196469
112MP0010030_abnormal_orbit_morphology0.92380845
113MP0004134_abnormal_chest_morphology0.91071467
114MP0000920_abnormal_myelination0.90512816
115MP0005397_hematopoietic_system_phenotyp0.90105676
116MP0001545_abnormal_hematopoietic_system0.90105676
117MP0005671_abnormal_response_to0.89694502
118MP0004885_abnormal_endolymph0.88687911
119MP0002084_abnormal_developmental_patter0.87079964
120MP0001730_embryonic_growth_arrest0.86814457
121MP0001145_abnormal_male_reproductive0.86301535
122MP0002234_abnormal_pharynx_morphology0.85772991
123MP0005670_abnormal_white_adipose0.85589594
124MP0004133_heterotaxia0.85281275
125MP0002752_abnormal_somatic_nervous0.85095195
126MP0005386_behavior/neurological_phenoty0.84476665
127MP0004924_abnormal_behavior0.84476665
128MP0003806_abnormal_nucleotide_metabolis0.84074486
129MP0002396_abnormal_hematopoietic_system0.83233723
130MP0002282_abnormal_trachea_morphology0.82966629
131MP0001970_abnormal_pain_threshold0.82755900
132MP0002066_abnormal_motor_capabilities/c0.82652028
133MP0000955_abnormal_spinal_cord0.82521473
134MP0000639_abnormal_adrenal_gland0.81612558
135MP0002102_abnormal_ear_morphology0.80767836
136MP0000703_abnormal_thymus_morphology0.80440715
137MP0005083_abnormal_biliary_tract0.80285820
138MP0003890_abnormal_embryonic-extraembry0.78516982
139MP0000049_abnormal_middle_ear0.75760077
140MP0001324_abnormal_eye_pigmentation0.74429414
141MP0002229_neurodegeneration0.72776366
142MP0002733_abnormal_thermal_nociception0.72374301
143MP0002019_abnormal_tumor_incidence0.72098372
144MP0001286_abnormal_eye_development0.71667357
145MP0002751_abnormal_autonomic_nervous0.71383345
146MP0001963_abnormal_hearing_physiology0.71213810
147MP0001270_distended_abdomen0.70827246
148MP0002085_abnormal_embryonic_tissue0.70749233
149MP0001919_abnormal_reproductive_system0.70227183
150MP0002735_abnormal_chemical_nociception0.69993024
151MP0001764_abnormal_homeostasis0.69021858
152MP0009765_abnormal_xenobiotic_induced0.68913219
153MP0003878_abnormal_ear_physiology0.68883925
154MP0005377_hearing/vestibular/ear_phenot0.68883925
155MP0003172_abnormal_lysosome_physiology0.68849340
156MP0009278_abnormal_bone_marrow0.68587769
157MP0000350_abnormal_cell_proliferation0.68278689
158MP0001697_abnormal_embryo_size0.67938063
159MP0004215_abnormal_myocardial_fiber0.67829078
160MP0002277_abnormal_respiratory_mucosa0.66506926
161MP0002089_abnormal_postnatal_growth/wei0.66342542
162MP0009333_abnormal_splenocyte_physiolog0.65463600
163MP0008873_increased_physiological_sensi0.64466170
164MP0005391_vision/eye_phenotype0.64060792
165MP0005380_embryogenesis_phenotype0.61646660
166MP0001672_abnormal_embryogenesis/_devel0.61646660
167MP0003937_abnormal_limbs/digits/tail_de0.59543293
168MP0008875_abnormal_xenobiotic_pharmacok0.59415578

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.82884734
2Absent/shortened dynein arms (HP:0200106)6.82884734
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.70809492
4Abnormal respiratory motile cilium morphology (HP:0005938)5.48495007
5Abnormal respiratory epithelium morphology (HP:0012253)5.48495007
6Abnormal respiratory motile cilium physiology (HP:0012261)4.87492012
7Abnormal ciliary motility (HP:0012262)4.66222427
8Methylmalonic acidemia (HP:0002912)3.99907552
9Hyperglycinemia (HP:0002154)3.87244998
10Medial flaring of the eyebrow (HP:0010747)3.65504366
11Rhinitis (HP:0012384)3.63194220
12Nasal polyposis (HP:0100582)3.62075437
13Carpal bone hypoplasia (HP:0001498)3.56264442
14Acute necrotizing encephalopathy (HP:0006965)3.47718263
15Gait imbalance (HP:0002141)3.40245931
16Mitochondrial inheritance (HP:0001427)3.38328576
17Colon cancer (HP:0003003)3.33695025
18Microvesicular hepatic steatosis (HP:0001414)3.32785912
19Methylmalonic aciduria (HP:0012120)3.31079878
20Retinal dysplasia (HP:0007973)3.29733148
21Increased hepatocellular lipid droplets (HP:0006565)3.28432698
22Abnormal mitochondria in muscle tissue (HP:0008316)3.20860508
23Renal cortical cysts (HP:0000803)3.19116443
24Increased CSF lactate (HP:0002490)3.17195259
25Congenital primary aphakia (HP:0007707)3.13373500
26Acute encephalopathy (HP:0006846)3.12119921
27Hepatocellular necrosis (HP:0001404)3.11173258
28Abnormality of the nasal mucosa (HP:0000433)3.10398660
29Abnormal hair whorl (HP:0010721)3.04926524
30Renal Fanconi syndrome (HP:0001994)3.02724633
31Infertility (HP:0000789)3.02612532
32Tubulointerstitial nephritis (HP:0001970)3.02290840
33Nephronophthisis (HP:0000090)2.99378486
34True hermaphroditism (HP:0010459)2.97231283
35Progressive macrocephaly (HP:0004481)2.96733861
36Nephrogenic diabetes insipidus (HP:0009806)2.96352625
37Lipid accumulation in hepatocytes (HP:0006561)2.87827964
38Abnormal protein glycosylation (HP:0012346)2.85376823
39Abnormal glycosylation (HP:0012345)2.85376823
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.85376823
41Abnormal protein N-linked glycosylation (HP:0012347)2.85376823
42Abnormality of the anterior horn cell (HP:0006802)2.83681357
43Degeneration of anterior horn cells (HP:0002398)2.83681357
44Increased intramyocellular lipid droplets (HP:0012240)2.79900754
45Bronchiectasis (HP:0002110)2.79674275
46Type I transferrin isoform profile (HP:0003642)2.79178844
47Increased serum pyruvate (HP:0003542)2.74841835
48Abnormality of the fingertips (HP:0001211)2.69351324
493-Methylglutaconic aciduria (HP:0003535)2.65165477
50Focal motor seizures (HP:0011153)2.63832038
51Focal seizures (HP:0007359)2.61489216
52Vaginal atresia (HP:0000148)2.53887582
53Broad distal phalanx of finger (HP:0009836)2.48659616
54Hepatic necrosis (HP:0002605)2.48211757
55Genital tract atresia (HP:0001827)2.46919104
56Abnormality of the labia minora (HP:0012880)2.45307712
57Abnormality of midbrain morphology (HP:0002418)2.44303399
58Molar tooth sign on MRI (HP:0002419)2.44303399
59Recurrent sinusitis (HP:0011108)2.39534878
60Cerebral edema (HP:0002181)2.36601208
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36096766
62Neoplasm of the heart (HP:0100544)2.33802635
63Aplasia/Hypoplasia of the lens (HP:0008063)2.32567821
64Specific learning disability (HP:0001328)2.32008361
65Poor coordination (HP:0002370)2.31285542
66Anhidrosis (HP:0000970)2.31267080
67Type II lissencephaly (HP:0007260)2.28303894
68Dry hair (HP:0011359)2.26103428
69Chronic bronchitis (HP:0004469)2.24828734
70Abnormality of glycolysis (HP:0004366)2.24297396
71Bronchitis (HP:0012387)2.24192620
72Abolished electroretinogram (ERG) (HP:0000550)2.23912857
73Recurrent bronchitis (HP:0002837)2.23768544
74Aplasia/hypoplasia of the uterus (HP:0008684)2.23535546
75Hemiparesis (HP:0001269)2.23454610
76Postaxial foot polydactyly (HP:0001830)2.23335509
77Hypoplasia of the uterus (HP:0000013)2.22130914
78Respiratory failure (HP:0002878)2.19143698
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18242841
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18242841
81Visual hallucinations (HP:0002367)2.17933045
82Abnormality of vitamin B metabolism (HP:0004340)2.17839384
83Decreased testicular size (HP:0008734)2.17408483
84Lactic acidosis (HP:0003128)2.15345513
85Pancreatic fibrosis (HP:0100732)2.15075316
86Increased serum lactate (HP:0002151)2.14390255
87Increased muscle lipid content (HP:0009058)2.14334441
88Dicarboxylic aciduria (HP:0003215)2.12647774
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12647774
90Abnormal biliary tract physiology (HP:0012439)2.11515417
91Bile duct proliferation (HP:0001408)2.11515417
92Chronic sinusitis (HP:0011109)2.11415083
93Entropion (HP:0000621)2.11128563
94Abnormality of the renal medulla (HP:0100957)2.10891155
95Enlarged kidneys (HP:0000105)2.09453809
96Limb dystonia (HP:0002451)2.08423770
97Exertional dyspnea (HP:0002875)2.08391539
98Lissencephaly (HP:0001339)2.08012611
99Acute lymphatic leukemia (HP:0006721)2.06495940
100Recurrent otitis media (HP:0000403)2.05864490
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05526293
102Pancreatic islet-cell hyperplasia (HP:0004510)2.05370008
103Abnormality of the vitamin B12 metabolism (HP:0004341)2.04615939
104Abnormality of the renal cortex (HP:0011035)2.03757035
105Abnormality of glycine metabolism (HP:0010895)2.03393890
106Abnormality of serine family amino acid metabolism (HP:0010894)2.03393890
107Severe visual impairment (HP:0001141)2.02069931
108Exercise intolerance (HP:0003546)2.01663149
109Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00913589
110Hypoplasia of the brainstem (HP:0002365)2.00913589
111Male pseudohermaphroditism (HP:0000037)2.00326494
112Abnormality of cells of the erythroid lineage (HP:0012130)2.00222631
113Gonadotropin excess (HP:0000837)1.96326678
114Reduced antithrombin III activity (HP:0001976)1.91468691
115Abnormality of renal resorption (HP:0011038)1.86809757
116Abnormality of methionine metabolism (HP:0010901)1.85622777
117Anencephaly (HP:0002323)1.83361797
118Hip dysplasia (HP:0001385)1.81418867
119Multicystic kidney dysplasia (HP:0000003)1.81081015
120Sclerocornea (HP:0000647)1.80904950
121Preaxial hand polydactyly (HP:0001177)1.80799292
122Tubulointerstitial abnormality (HP:0001969)1.79072465
123Asplenia (HP:0001746)1.78507271
124Disproportionate short-trunk short stature (HP:0003521)1.78450092
125Median cleft lip (HP:0000161)1.78255382
126Abnormal lung lobation (HP:0002101)1.77680625
127Metabolic acidosis (HP:0001942)1.76907712
128Lethargy (HP:0001254)1.76257622
129Midline defect of the nose (HP:0004122)1.76247193
130Left ventricular hypertrophy (HP:0001712)1.75845370
131Broad-based gait (HP:0002136)1.74833509
132Esotropia (HP:0000565)1.73968133
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73455472
134Hyperalaninemia (HP:0003348)1.73455472
135Anteriorly placed anus (HP:0001545)1.71698531
136Peripheral hypomyelination (HP:0007182)1.71410857
137Supranuclear gaze palsy (HP:0000605)1.67700505
138Bifid tongue (HP:0010297)1.66077987
139Postaxial hand polydactyly (HP:0001162)1.65954862
140Thickened helices (HP:0000391)1.65177869
141Poor speech (HP:0002465)1.62745044
142Narrow forehead (HP:0000341)1.62609797
143Slow-growing hair (HP:0002217)1.60539579
144Abnormality of hair growth rate (HP:0011363)1.60539579
145Reticulocytopenia (HP:0001896)1.58856863
146Septate vagina (HP:0001153)1.58762538
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.56967810
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.56967810
149Alacrima (HP:0000522)1.54489590
150Cystic liver disease (HP:0006706)1.54292819
151Generalized hypotonia (HP:0001290)1.53389477
152Retinitis pigmentosa (HP:0000510)1.52393087
153Partial duplication of thumb phalanx (HP:0009944)1.51686919
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.50997745
155Prolonged QT interval (HP:0001657)1.48779172
156Abnormal EKG (HP:0003115)1.48477892
157Decreased lacrimation (HP:0000633)1.48411892
158Abnormal rod and cone electroretinograms (HP:0008323)1.48314026
159Pancreatic cysts (HP:0001737)1.46843425
160Highly arched eyebrow (HP:0002553)1.46833120
161Broad foot (HP:0001769)1.46644165
162Impaired smooth pursuit (HP:0007772)1.46593904
163Polyphagia (HP:0002591)1.44695973
164Spastic gait (HP:0002064)1.44503633
165Failure to thrive in infancy (HP:0001531)1.44215413
166Tented upper lip vermilion (HP:0010804)1.43980004
167Amyotrophic lateral sclerosis (HP:0007354)1.43328123
168Psychosis (HP:0000709)1.43156189
169Supernumerary spleens (HP:0009799)1.42937888
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.42098932
171Meningocele (HP:0002435)1.42094178
172Congenital hepatic fibrosis (HP:0002612)1.41176862
173Abnormality of binocular vision (HP:0011514)1.40949582
174Diplopia (HP:0000651)1.40949582
175Widely spaced teeth (HP:0000687)1.40758295
176Abnormal number of erythroid precursors (HP:0012131)1.38871636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.36367505
2PRKD33.39106844
3MAP4K23.32523707
4BUB12.98626263
5NUAK12.84718411
6EIF2AK32.77994491
7PBK2.68570111
8UHMK12.65876690
9MST42.44890671
10VRK12.42661326
11MAPK152.40767441
12SRPK12.36656528
13ICK2.34209120
14TAF12.30900279
15BCKDK2.30856212
16MAPK132.11435116
17OBSCN2.11126504
18ZAK2.09050175
19PNCK2.08630688
20MAP4K11.98548749
21MAP3K101.90887949
22MUSK1.81666583
23MARK11.79646462
24NTRK21.76016100
25CDC71.72867018
26TTK1.72288683
27NTRK31.70127676
28PLK31.66650132
29SCYL21.66252873
30TNIK1.60313452
31SIK21.56677823
32TXK1.55963887
33MKNK11.52306797
34TYRO31.52003345
35BRSK21.51646266
36BRAF1.51549987
37BRD41.49799201
38ARAF1.47485288
39BCR1.45422057
40PIM21.43725039
41NEK11.38344348
42FES1.38018771
43RIPK11.37268282
44PLK41.36539048
45STK41.35361972
46MARK21.34231892
47CAMK1G1.33484531
48KDR1.32614418
49CCNB11.31375561
50INSRR1.31202897
51PAK61.30394151
52CAMK11.29020673
53DYRK31.28696853
54IRAK21.28175984
55KSR11.25171238
56FLT31.24270755
57WNK41.21018231
58FRK1.20493727
59STK391.17925429
60PLK11.17894872
61PRKD21.11347324
62STK161.09987662
63SGK2231.07914627
64SGK4941.07914627
65EIF2AK21.07370927
66PTK2B1.04214385
67SIK31.03076379
68STK31.02583424
69MAP3K110.97862212
70CDK30.97045458
71CDK190.96502037
72RPS6KA20.96399938
73CSNK1G30.94581557
74EPHB20.94348775
75MAPKAPK50.92942441
76CDK50.92038464
77NLK0.91532207
78PKN10.90259695
79IKBKE0.90031405
80SGK20.88802489
81CLK10.88584991
82CDC42BPA0.88316587
83DYRK1A0.88172277
84AKT30.87144265
85HIPK20.86825407
86TRIM280.85908148
87RPS6KA40.84449862
88ATM0.84240606
89CSNK1A1L0.84040476
90CSNK1G20.84004422
91YES10.83469098
92MAP3K40.82969763
93MKNK20.81499190
94TGFBR10.81496261
95CASK0.80490682
96EPHB10.78303976
97EPHA40.77922755
98ACVR1B0.77174657
99MAP2K70.77165322
100KIT0.76607862
101DYRK1B0.76197222
102MAP3K50.75099572
103AURKB0.74086731
104BTK0.73957114
105ADRBK20.72589037
106BMPR1B0.71813807
107ATR0.71775995
108PRKCQ0.70704191
109PINK10.69084221
110SYK0.68447033
111TAOK30.67869436
112CSNK1G10.66377211
113CDK60.64781086
114NEK20.63214985
115IKBKB0.62908703
116GRK10.62511358
117GRK70.62500036
118RPS6KC10.61800035
119RPS6KL10.61800035
120IRAK10.60977847
121RPS6KA50.60348897
122MAP3K130.59429188
123NEK90.59407279
124TGFBR20.58844055
125RAF10.58729168
126CDK150.58637176
127PASK0.58299663
128CDK180.58232611
129TESK10.57545657
130CDK11A0.56641523
131MAP2K60.56505152
132TSSK60.56401402
133DYRK20.55950041
134CSNK2A20.55399197
135PLK20.54996372
136RIPK40.54376823
137FGFR20.54122134
138EIF2AK10.52155168
139RPS6KA60.51912136
140PDK30.51578995
141PDK40.51578995
142CAMK2B0.51308740
143MAP3K70.51194824
144FYN0.50493323
145TBK10.50449131
146FGFR10.50124179
147CDK70.50082098
148PRKG10.49709065
149PHKG20.48692885
150PHKG10.48692885
151PAK30.48203607
152FGR0.47968871
153BRSK10.47892826
154CSF1R0.47549307
155CSNK2A10.47516974
156TESK20.47031206
157CHUK0.47010459
158AURKA0.46465639
159LRRK20.46330609
160CHEK20.45979482
161ERBB20.45921096
162NME10.45670709
163CDK90.43657316
164OXSR10.43404138
165WNK30.43182262
166MAP3K120.39358928
167LCK0.39180767
168CSNK1A10.37261619
169PRKCE0.37034601
170CHEK10.36652140
171CSNK1E0.34359890

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.11009966
2Non-homologous end-joining_Homo sapiens_hsa034502.71231140
3RNA polymerase_Homo sapiens_hsa030202.62315200
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50862318
5Protein export_Homo sapiens_hsa030602.50694618
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35074515
7Propanoate metabolism_Homo sapiens_hsa006402.33852740
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26582419
9Circadian entrainment_Homo sapiens_hsa047132.17984875
10Fatty acid elongation_Homo sapiens_hsa000622.17716779
11DNA replication_Homo sapiens_hsa030302.07130975
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04778428
13Olfactory transduction_Homo sapiens_hsa047402.04588830
14One carbon pool by folate_Homo sapiens_hsa006702.02353190
15Glutamatergic synapse_Homo sapiens_hsa047241.96885318
16Nicotine addiction_Homo sapiens_hsa050331.95388226
17Morphine addiction_Homo sapiens_hsa050321.89156593
18Insulin secretion_Homo sapiens_hsa049111.88833036
19Steroid biosynthesis_Homo sapiens_hsa001001.82947841
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.80996316
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80903301
22Amphetamine addiction_Homo sapiens_hsa050311.75607356
23Pyrimidine metabolism_Homo sapiens_hsa002401.75440811
24Long-term potentiation_Homo sapiens_hsa047201.74374304
25Nucleotide excision repair_Homo sapiens_hsa034201.73223205
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71346902
27Peroxisome_Homo sapiens_hsa041461.70507023
28Cardiac muscle contraction_Homo sapiens_hsa042601.69866425
29GABAergic synapse_Homo sapiens_hsa047271.65279675
30Cocaine addiction_Homo sapiens_hsa050301.60813405
31RNA transport_Homo sapiens_hsa030131.55526176
32Dopaminergic synapse_Homo sapiens_hsa047281.53640597
33p53 signaling pathway_Homo sapiens_hsa041151.51771319
34Ribosome_Homo sapiens_hsa030101.47767378
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47754855
36Primary immunodeficiency_Homo sapiens_hsa053401.46606124
37Serotonergic synapse_Homo sapiens_hsa047261.46259088
38Cholinergic synapse_Homo sapiens_hsa047251.42045959
39Renin secretion_Homo sapiens_hsa049241.40355839
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38873667
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38295760
42Taste transduction_Homo sapiens_hsa047421.36948604
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34625586
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31096833
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30661313
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28942922
47Axon guidance_Homo sapiens_hsa043601.27158157
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26163762
49T cell receptor signaling pathway_Homo sapiens_hsa046601.25965353
50Calcium signaling pathway_Homo sapiens_hsa040201.25445151
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.22493942
52Huntingtons disease_Homo sapiens_hsa050161.19200172
53Gastric acid secretion_Homo sapiens_hsa049711.17696867
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14497216
55Phototransduction_Homo sapiens_hsa047441.12972463
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12090549
57mRNA surveillance pathway_Homo sapiens_hsa030151.11554593
58Alcoholism_Homo sapiens_hsa050341.10989063
59Alzheimers disease_Homo sapiens_hsa050101.07889499
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07652742
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07388228
62Pyruvate metabolism_Homo sapiens_hsa006201.06795881
63cAMP signaling pathway_Homo sapiens_hsa040241.05596266
64Parkinsons disease_Homo sapiens_hsa050121.05443451
65Basal transcription factors_Homo sapiens_hsa030221.04535917
66Glutathione metabolism_Homo sapiens_hsa004801.02969746
67B cell receptor signaling pathway_Homo sapiens_hsa046621.01773730
68Butanoate metabolism_Homo sapiens_hsa006501.01435949
69Cell cycle_Homo sapiens_hsa041101.00445512
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00091033
71Oxytocin signaling pathway_Homo sapiens_hsa049211.00062612
72N-Glycan biosynthesis_Homo sapiens_hsa005101.00058612
73Selenocompound metabolism_Homo sapiens_hsa004500.99440955
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98214809
75Long-term depression_Homo sapiens_hsa047300.98210970
76Spliceosome_Homo sapiens_hsa030400.97769648
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.97254983
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93567891
79Wnt signaling pathway_Homo sapiens_hsa043100.93513397
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92951489
81Colorectal cancer_Homo sapiens_hsa052100.92755430
82Salivary secretion_Homo sapiens_hsa049700.92351079
83Fanconi anemia pathway_Homo sapiens_hsa034600.92270187
84Melanogenesis_Homo sapiens_hsa049160.91098178
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89998482
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89986728
87Dorso-ventral axis formation_Homo sapiens_hsa043200.85591728
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84890987
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84418456
90VEGF signaling pathway_Homo sapiens_hsa043700.84018919
91GnRH signaling pathway_Homo sapiens_hsa049120.83794620
92Gap junction_Homo sapiens_hsa045400.83682570
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83597046
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83195645
95Metabolic pathways_Homo sapiens_hsa011000.83185174
96Homologous recombination_Homo sapiens_hsa034400.82967848
97Regulation of autophagy_Homo sapiens_hsa041400.82018701
98Sulfur metabolism_Homo sapiens_hsa009200.81899846
99Non-small cell lung cancer_Homo sapiens_hsa052230.81728437
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81611558
101Carbon metabolism_Homo sapiens_hsa012000.81399130
102Ether lipid metabolism_Homo sapiens_hsa005650.79225052
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77701130
104Basal cell carcinoma_Homo sapiens_hsa052170.76446197
105* RNA degradation_Homo sapiens_hsa030180.76312830
106Arginine and proline metabolism_Homo sapiens_hsa003300.75413325
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74519119
108Oxidative phosphorylation_Homo sapiens_hsa001900.74188739
109Glucagon signaling pathway_Homo sapiens_hsa049220.73354352
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72857574
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69420829
112Base excision repair_Homo sapiens_hsa034100.68091502
113MAPK signaling pathway_Homo sapiens_hsa040100.68090693
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67465400
115Lysine degradation_Homo sapiens_hsa003100.65862539
116Dilated cardiomyopathy_Homo sapiens_hsa054140.65616598
117Mismatch repair_Homo sapiens_hsa034300.65599556
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.64704730
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64113146
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.63792365
121Chemokine signaling pathway_Homo sapiens_hsa040620.63489446
122Type II diabetes mellitus_Homo sapiens_hsa049300.62946843
123Hedgehog signaling pathway_Homo sapiens_hsa043400.62888626
124Oocyte meiosis_Homo sapiens_hsa041140.62885959
125Endometrial cancer_Homo sapiens_hsa052130.61876914
126Pancreatic secretion_Homo sapiens_hsa049720.61480554
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61430335
128Ras signaling pathway_Homo sapiens_hsa040140.60475564
129Choline metabolism in cancer_Homo sapiens_hsa052310.60201782
130ErbB signaling pathway_Homo sapiens_hsa040120.60117310
131Purine metabolism_Homo sapiens_hsa002300.59653970
132Acute myeloid leukemia_Homo sapiens_hsa052210.59244773
133beta-Alanine metabolism_Homo sapiens_hsa004100.59054221
134Caffeine metabolism_Homo sapiens_hsa002320.58249693
135Estrogen signaling pathway_Homo sapiens_hsa049150.58062369
136Fatty acid metabolism_Homo sapiens_hsa012120.56929411
137Notch signaling pathway_Homo sapiens_hsa043300.56015618
138Sulfur relay system_Homo sapiens_hsa041220.55746361
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54312019
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53587429
141Herpes simplex infection_Homo sapiens_hsa051680.52921931
142Pancreatic cancer_Homo sapiens_hsa052120.52905170
143Renal cell carcinoma_Homo sapiens_hsa052110.52143810
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52101302
145Synaptic vesicle cycle_Homo sapiens_hsa047210.51894780
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51550844
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.50863855
148Folate biosynthesis_Homo sapiens_hsa007900.50732779
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50521382
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49581850
151Circadian rhythm_Homo sapiens_hsa047100.49172246
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.47141376
153Rap1 signaling pathway_Homo sapiens_hsa040150.47024585
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46943912
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46932656
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46763907
157Antigen processing and presentation_Homo sapiens_hsa046120.45721909
158Tryptophan metabolism_Homo sapiens_hsa003800.43859613
159Epstein-Barr virus infection_Homo sapiens_hsa051690.39499154
160Type I diabetes mellitus_Homo sapiens_hsa049400.39016781
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36366144
162Primary bile acid biosynthesis_Homo sapiens_hsa001200.36105413
163Biosynthesis of amino acids_Homo sapiens_hsa012300.33334725
164Tyrosine metabolism_Homo sapiens_hsa003500.32663475
165Retinol metabolism_Homo sapiens_hsa008300.32087902
166Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30143430
167Chemical carcinogenesis_Homo sapiens_hsa052040.27572045
168Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27325175
169Arachidonic acid metabolism_Homo sapiens_hsa005900.26097377
170Nitrogen metabolism_Homo sapiens_hsa009100.26083207
171TGF-beta signaling pathway_Homo sapiens_hsa043500.24138762
172Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24089902
173Fatty acid degradation_Homo sapiens_hsa000710.23882900
174Autoimmune thyroid disease_Homo sapiens_hsa053200.22993794
175Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21841230

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