DCPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5' mRNA cap structure, which appear in the 3' -> 5' mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.85034237
2DNA strand elongation involved in DNA replication (GO:0006271)4.94742796
3DNA deamination (GO:0045006)4.93938852
4telomere maintenance via semi-conservative replication (GO:0032201)4.85901131
5viral transcription (GO:0019083)4.79201695
6DNA strand elongation (GO:0022616)4.68851942
7translational termination (GO:0006415)4.67283711
8ribosomal small subunit biogenesis (GO:0042274)4.48780905
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37454402
10cotranslational protein targeting to membrane (GO:0006613)4.31340410
11protein targeting to ER (GO:0045047)4.26804841
12translational elongation (GO:0006414)4.25229507
13maturation of SSU-rRNA (GO:0030490)4.23854481
14rRNA modification (GO:0000154)4.22813677
15telomere maintenance via recombination (GO:0000722)4.21815300
16DNA unwinding involved in DNA replication (GO:0006268)4.14196062
17DNA replication initiation (GO:0006270)4.06197330
18protein localization to endoplasmic reticulum (GO:0070972)4.04242086
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.04053089
20proteasome assembly (GO:0043248)3.91651794
21mitotic recombination (GO:0006312)3.89195432
22formation of translation preinitiation complex (GO:0001731)3.84439106
23establishment of integrated proviral latency (GO:0075713)3.79765158
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79521614
25translational initiation (GO:0006413)3.78978420
26telomere maintenance via telomere lengthening (GO:0010833)3.78899293
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78804034
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.74042747
29viral life cycle (GO:0019058)3.68018127
30valine metabolic process (GO:0006573)3.63757853
31cellular protein complex disassembly (GO:0043624)3.62625313
32ribosomal large subunit biogenesis (GO:0042273)3.62543935
33L-serine metabolic process (GO:0006563)3.58748587
34nucleobase biosynthetic process (GO:0046112)3.56874641
35CENP-A containing nucleosome assembly (GO:0034080)3.55149027
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54367019
37protein localization to kinetochore (GO:0034501)3.51863848
38folic acid-containing compound biosynthetic process (GO:0009396)3.51241474
39chromatin remodeling at centromere (GO:0031055)3.43597701
40rRNA methylation (GO:0031167)3.42717002
41DNA replication checkpoint (GO:0000076)3.42168673
42ribonucleoprotein complex biogenesis (GO:0022613)3.41915003
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.36769526
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35017355
45translation (GO:0006412)3.33945100
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31356066
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30752532
48ATP synthesis coupled proton transport (GO:0015986)3.30752532
49protein complex disassembly (GO:0043241)3.26365826
50establishment of viral latency (GO:0019043)3.22600853
51IMP biosynthetic process (GO:0006188)3.22371991
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21741617
53tRNA aminoacylation for protein translation (GO:0006418)3.17811167
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17293380
55spliceosomal snRNP assembly (GO:0000387)3.16950022
56negative regulation of ligase activity (GO:0051352)3.16679447
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16679447
58rRNA processing (GO:0006364)3.16057331
59mitotic sister chromatid segregation (GO:0000070)3.12985158
60DNA replication-independent nucleosome assembly (GO:0006336)3.12954045
61DNA replication-independent nucleosome organization (GO:0034724)3.12954045
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12871824
63transcription-coupled nucleotide-excision repair (GO:0006283)3.12840068
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12598758
65positive regulation of ligase activity (GO:0051351)3.12147471
66tRNA aminoacylation (GO:0043039)3.10784531
67amino acid activation (GO:0043038)3.10784531
68guanosine-containing compound biosynthetic process (GO:1901070)3.10635868
69DNA replication-dependent nucleosome assembly (GO:0006335)3.10107101
70DNA replication-dependent nucleosome organization (GO:0034723)3.10107101
71* nuclear-transcribed mRNA catabolic process (GO:0000956)3.09463312
72branched-chain amino acid catabolic process (GO:0009083)3.09388726
73macromolecular complex disassembly (GO:0032984)3.08589973
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.08546945
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06233483
76purine nucleobase biosynthetic process (GO:0009113)3.05026942
77GDP-mannose metabolic process (GO:0019673)3.04295379
78protein localization to chromosome, centromeric region (GO:0071459)3.03663536
79IMP metabolic process (GO:0046040)3.03109071
80rRNA metabolic process (GO:0016072)3.02866469
81viral mRNA export from host cell nucleus (GO:0046784)3.02425556
82DNA ligation (GO:0006266)3.01679068
83pteridine-containing compound biosynthetic process (GO:0042559)3.01570706
84spliceosomal complex assembly (GO:0000245)3.01399733
85protein maturation by protein folding (GO:0022417)3.00765658
86termination of RNA polymerase III transcription (GO:0006386)2.96743424
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.96743424
88pseudouridine synthesis (GO:0001522)2.96313998
89nucleobase-containing small molecule interconversion (GO:0015949)2.96093677
90ribosome biogenesis (GO:0042254)2.94806399
91* mRNA catabolic process (GO:0006402)2.93758959
92regulation of ubiquitin-protein transferase activity (GO:0051438)2.93378732
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92581894
94* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92550753
95DNA catabolic process, exonucleolytic (GO:0000738)2.92373052
96kinetochore organization (GO:0051383)2.91413872
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90834088
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90834088
99* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89275604
100GTP biosynthetic process (GO:0006183)2.88654141
101establishment of chromosome localization (GO:0051303)2.88104425
102telomere organization (GO:0032200)2.87593387
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86796078
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86796078
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86796078
106metaphase plate congression (GO:0051310)2.86686644
107* RNA catabolic process (GO:0006401)2.86681624
108regulation of ligase activity (GO:0051340)2.86544592
109purine nucleotide salvage (GO:0032261)2.85661505
110serine family amino acid biosynthetic process (GO:0009070)2.85478170
111telomere maintenance (GO:0000723)2.84478294
112cellular component biogenesis (GO:0044085)2.82984997
113cellular response to interferon-beta (GO:0035458)2.82708177
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82197248
115UTP biosynthetic process (GO:0006228)2.82129427
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.82126544
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82126544
118regulation of mitochondrial translation (GO:0070129)2.81625687
119mitotic metaphase plate congression (GO:0007080)2.80147058
120G1/S transition of mitotic cell cycle (GO:0000082)2.78528416
121cell cycle G1/S phase transition (GO:0044843)2.78528416
122protein complex biogenesis (GO:0070271)2.77504134
123protein targeting to mitochondrion (GO:0006626)2.77192815
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77082492
125mitochondrial respiratory chain complex assembly (GO:0033108)2.76230945
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.76081913
127mitotic nuclear envelope disassembly (GO:0007077)2.75074852
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75071231
129protein targeting to membrane (GO:0006612)2.74721461
130base-excision repair (GO:0006284)2.74042138
131mismatch repair (GO:0006298)2.73400189
132cullin deneddylation (GO:0010388)2.70683092
133regulation of cellular amino acid metabolic process (GO:0006521)2.69605248
134protein deneddylation (GO:0000338)2.68904539
135histone exchange (GO:0043486)2.68131403
136somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66763157
137somatic hypermutation of immunoglobulin genes (GO:0016446)2.66763157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96988289
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.96195708
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87897880
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50538809
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.25442799
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16310741
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.15420070
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05717096
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99790517
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98105690
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.85684999
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.84967354
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83699882
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77630729
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75541120
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75278042
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74648721
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63226804
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55490067
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44031540
21XRN2_22483619_ChIP-Seq_HELA_Human2.42198041
22* VDR_23849224_ChIP-Seq_CD4+_Human2.30659876
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18322477
24FOXP3_21729870_ChIP-Seq_TREG_Human2.14565325
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12215346
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10266000
27DCP1A_22483619_ChIP-Seq_HELA_Human2.08621883
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02688150
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00791879
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95483296
31GABP_19822575_ChIP-Seq_HepG2_Human1.89970578
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.80356719
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78748074
34CIITA_25753668_ChIP-Seq_RAJI_Human1.74835589
35* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73900156
36TTF2_22483619_ChIP-Seq_HELA_Human1.72138894
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70411878
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70379925
39* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69185638
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69070622
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.66000831
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64084514
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63612783
44AR_21909140_ChIP-Seq_LNCAP_Human1.60996421
45ELK1_19687146_ChIP-ChIP_HELA_Human1.59811818
46* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59438570
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54140895
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.51781593
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51687475
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49180831
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49103683
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48445875
53MYC_22102868_ChIP-Seq_BL_Human1.47825268
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46415969
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45762955
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42213974
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37880272
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37724306
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36744067
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32224385
61KDM5A_27292631_Chip-Seq_BREAST_Human1.31712554
62VDR_21846776_ChIP-Seq_THP-1_Human1.31619055
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21014261
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16454989
65* SPI1_23547873_ChIP-Seq_NB4_Human1.16193565
66* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15640822
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14472941
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09512096
69TFEB_21752829_ChIP-Seq_HELA_Human1.08114129
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06359271
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05644244
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05408611
73MYC_18940864_ChIP-ChIP_HL60_Human1.04277276
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03708180
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02347177
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01649644
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01349354
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99028428
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98700150
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.97680412
81SCL_19346495_ChIP-Seq_HPC-7_Human0.97675126
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97404022
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96792151
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96396518
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96332232
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95592528
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95523331
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95002438
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93757382
90FOXP1_21924763_ChIP-Seq_HESCs_Human0.92353945
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92243783
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91427537
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90940635
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90882482
95* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90505107
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89632940
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89290199
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88021861
99MAF_26560356_Chip-Seq_TH2_Human0.87593851
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.86920161
101BCL6_27268052_Chip-Seq_Bcells_Human0.85753786
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85712664
103EGR1_19374776_ChIP-ChIP_THP-1_Human0.85673874
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85608638
105PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85316213
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85152428
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84493721
108MAF_26560356_Chip-Seq_TH1_Human0.84249922
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83427920
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.82046805
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80559481
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75904023
113IRF1_19129219_ChIP-ChIP_H3396_Human0.74654085
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74571365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66816404
2MP0010094_abnormal_chromosome_stability4.09889275
3MP0004957_abnormal_blastocyst_morpholog3.85789028
4MP0008057_abnormal_DNA_replication3.84615670
5MP0003077_abnormal_cell_cycle3.59490772
6MP0003806_abnormal_nucleotide_metabolis3.50049805
7MP0003111_abnormal_nucleus_morphology3.41862357
8MP0008058_abnormal_DNA_repair3.20416132
9MP0002396_abnormal_hematopoietic_system2.90286704
10MP0008932_abnormal_embryonic_tissue2.47622378
11MP0008007_abnormal_cellular_replicative2.46584377
12MP0005171_absent_coat_pigmentation2.45114257
13MP0003763_abnormal_thymus_physiology2.04802057
14MP0009379_abnormal_foot_pigmentation2.04278597
15MP0000015_abnormal_ear_pigmentation2.01128537
16MP0003186_abnormal_redox_activity1.98812865
17MP0001730_embryonic_growth_arrest1.93252630
18MP0000490_abnormal_crypts_of1.91312452
19MP0002132_abnormal_respiratory_system1.79261391
20MP0006036_abnormal_mitochondrial_physio1.72681309
21MP0009333_abnormal_splenocyte_physiolog1.72581019
22MP0004381_abnormal_hair_follicle1.64913696
23MP0002398_abnormal_bone_marrow1.63990022
24MP0003786_premature_aging1.63653196
25MP0000350_abnormal_cell_proliferation1.60693041
26MP0003656_abnormal_erythrocyte_physiolo1.59685638
27MP0006054_spinal_hemorrhage1.55566707
28MP0002019_abnormal_tumor_incidence1.52553733
29MP0005075_abnormal_melanosome_morpholog1.52399047
30MP0000313_abnormal_cell_death1.48413031
31MP0002722_abnormal_immune_system1.48135494
32MP0000689_abnormal_spleen_morphology1.48125450
33MP0005671_abnormal_response_to1.47837486
34MP0004147_increased_porphyrin_level1.47208166
35MP0005397_hematopoietic_system_phenotyp1.42654557
36MP0001545_abnormal_hematopoietic_system1.42654557
37MP0000685_abnormal_immune_system1.41227221
38MP0000703_abnormal_thymus_morphology1.38902476
39MP0001835_abnormal_antigen_presentation1.36671669
40MP0002429_abnormal_blood_cell1.36601136
41MP0008877_abnormal_DNA_methylation1.32210531
42MP0005360_urolithiasis1.32208205
43MP0000716_abnormal_immune_system1.29768576
44MP0002080_prenatal_lethality1.29279252
45MP0009785_altered_susceptibility_to1.28508457
46MP0001697_abnormal_embryo_size1.26211444
47MP0001800_abnormal_humoral_immune1.26084958
48MP0008875_abnormal_xenobiotic_pharmacok1.23200812
49MP0008260_abnormal_autophagy1.22957172
50MP0003136_yellow_coat_color1.22022404
51MP0004808_abnormal_hematopoietic_stem1.21671507
52MP0002420_abnormal_adaptive_immunity1.20517974
53MP0005332_abnormal_amino_acid1.19459734
54MP0003718_maternal_effect1.17999321
55MP0001819_abnormal_immune_cell1.17709881
56MP0003123_paternal_imprinting1.15276417
57MP0002723_abnormal_immune_serum1.12001935
58MP0005025_abnormal_response_to1.11779455
59MP0001672_abnormal_embryogenesis/_devel1.11170901
60MP0005380_embryogenesis_phenotype1.11170901
61MP0006035_abnormal_mitochondrial_morpho1.05906829
62MP0002452_abnormal_antigen_presenting1.05673079
63MP0002139_abnormal_hepatobiliary_system1.03966160
64MP0003984_embryonic_growth_retardation1.03275010
65MP0005174_abnormal_tail_pigmentation1.00908840
66MP0003567_abnormal_fetal_cardiomyocyte1.00858858
67MP0004133_heterotaxia0.99975798
68MP0001853_heart_inflammation0.99895977
69MP0001873_stomach_inflammation0.98690318
70MP0002088_abnormal_embryonic_growth/wei0.97941020
71MP0010352_gastrointestinal_tract_polyps0.97003682
72MP0002405_respiratory_system_inflammati0.95323746
73MP0005000_abnormal_immune_tolerance0.94505523
74MP0000358_abnormal_cell_content/0.94364047
75MP0002085_abnormal_embryonic_tissue0.91913627
76MP0005330_cardiomyopathy0.91735973
77MP0001293_anophthalmia0.90739570
78MP0002148_abnormal_hypersensitivity_rea0.88696568
79MP0001764_abnormal_homeostasis0.88458385
80MP0000465_gastrointestinal_hemorrhage0.88076938
81MP0001661_extended_life_span0.86344180
82MP0002138_abnormal_hepatobiliary_system0.86028369
83MP0005395_other_phenotype0.85773081
84MP0004233_abnormal_muscle_weight0.85424695
85MP0005451_abnormal_body_composition0.84444349
86MP0006292_abnormal_olfactory_placode0.84155457
87MP0005464_abnormal_platelet_physiology0.83768602
88MP0002938_white_spotting0.83294381
89MP0000566_synostosis0.82565618
90MP0002210_abnormal_sex_determination0.82534045
91MP0002006_tumorigenesis0.82463571
92MP0005083_abnormal_biliary_tract0.82254557
93MP0005266_abnormal_metabolism0.82195313
94MP0002877_abnormal_melanocyte_morpholog0.82183095
95MP0002086_abnormal_extraembryonic_tissu0.81609763
96MP0002095_abnormal_skin_pigmentation0.80830872
97MP0009840_abnormal_foam_cell0.79704397
98MP0005319_abnormal_enzyme/_coenzyme0.79696335
99MP0000858_altered_metastatic_potential0.79118432
100MP0001145_abnormal_male_reproductive0.78821556
101MP0003221_abnormal_cardiomyocyte_apopto0.77356111
102MP0010030_abnormal_orbit_morphology0.77339492
103MP0004197_abnormal_fetal_growth/weight/0.76023431
104MP0010155_abnormal_intestine_physiology0.75452008
105MP0000372_irregular_coat_pigmentation0.75146194
106MP0001929_abnormal_gametogenesis0.74654501
107MP0004185_abnormal_adipocyte_glucose0.74360109
108MP0002166_altered_tumor_susceptibility0.73510873
109MP0002163_abnormal_gland_morphology0.72878937
110MP0009697_abnormal_copulation0.72792195
111MP0002084_abnormal_developmental_patter0.72662122
112MP0005408_hypopigmentation0.71606733
113MP0001529_abnormal_vocalization0.70298181
114MP0002254_reproductive_system_inflammat0.70200780
115MP0008469_abnormal_protein_level0.69873514
116MP0001790_abnormal_immune_system0.69207778
117MP0005387_immune_system_phenotype0.69207778
118MP0002419_abnormal_innate_immunity0.69167354
119MP0002933_joint_inflammation0.68496034
120MP0000598_abnormal_liver_morphology0.68319254
121MP0000678_abnormal_parathyroid_gland0.68229840
122MP0003195_calcinosis0.68085980
123MP0003436_decreased_susceptibility_to0.67442217
124MP0001845_abnormal_inflammatory_respons0.65486983
125MP0002837_dystrophic_cardiac_calcinosis0.65089124
126MP0003252_abnormal_bile_duct0.64828512
127MP0000653_abnormal_sex_gland0.64767895
128MP0005501_abnormal_skin_physiology0.64113320
129MP0000609_abnormal_liver_physiology0.63911785

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.09910711
2Reticulocytopenia (HP:0001896)5.03041458
3Abnormal number of erythroid precursors (HP:0012131)4.89528313
4Aplastic anemia (HP:0001915)4.00822137
5Testicular atrophy (HP:0000029)3.94878808
6Cerebral hypomyelination (HP:0006808)3.72544083
7Birth length less than 3rd percentile (HP:0003561)3.39790593
8Thrombocytosis (HP:0001894)3.39761040
9Macrocytic anemia (HP:0001972)3.33667176
10Abnormality of glycolysis (HP:0004366)3.27188854
11Increased serum pyruvate (HP:0003542)3.27188854
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26596536
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26596536
14Oral leukoplakia (HP:0002745)3.23414605
15Pallor (HP:0000980)3.21365766
16Hepatocellular necrosis (HP:0001404)3.11026552
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.10855690
18IgM deficiency (HP:0002850)3.09817959
19Hepatic necrosis (HP:0002605)3.09125079
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06484354
21Pendular nystagmus (HP:0012043)3.02422184
22Cerebral edema (HP:0002181)2.99197678
23Type I transferrin isoform profile (HP:0003642)2.93011169
24Progressive macrocephaly (HP:0004481)2.90554249
25Increased serum lactate (HP:0002151)2.87711879
26Colon cancer (HP:0003003)2.81102211
27Acute hepatic failure (HP:0006554)2.76100110
28Agammaglobulinemia (HP:0004432)2.72640422
29Mitochondrial inheritance (HP:0001427)2.70815126
3011 pairs of ribs (HP:0000878)2.70663181
31Pancytopenia (HP:0001876)2.69846299
32Cutaneous melanoma (HP:0012056)2.68960708
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68881385
34Lipid accumulation in hepatocytes (HP:0006561)2.67644193
35Increased hepatocellular lipid droplets (HP:0006565)2.64375822
36Increased CSF lactate (HP:0002490)2.61382448
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59897332
38Cholecystitis (HP:0001082)2.59372854
39Abnormal gallbladder physiology (HP:0012438)2.59372854
40Acute necrotizing encephalopathy (HP:0006965)2.53066579
41Asplenia (HP:0001746)2.52896861
42Chromsome breakage (HP:0040012)2.52048499
43Squamous cell carcinoma (HP:0002860)2.51502138
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48619319
45Exertional dyspnea (HP:0002875)2.46831958
46Abnormal mitochondria in muscle tissue (HP:0008316)2.46366934
47Microvesicular hepatic steatosis (HP:0001414)2.43993639
48Selective tooth agenesis (HP:0001592)2.42573122
49Microretrognathia (HP:0000308)2.41995690
50Renal Fanconi syndrome (HP:0001994)2.41315161
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36661270
52Degeneration of anterior horn cells (HP:0002398)2.34915699
53Abnormality of the anterior horn cell (HP:0006802)2.34915699
543-Methylglutaconic aciduria (HP:0003535)2.34821204
55Poikiloderma (HP:0001029)2.33326580
56Breast hypoplasia (HP:0003187)2.32897183
57Progressive muscle weakness (HP:0003323)2.31659763
58Prolonged partial thromboplastin time (HP:0003645)2.31657591
59Reduced antithrombin III activity (HP:0001976)2.31600771
60Abnormal lung lobation (HP:0002101)2.30603811
61Myelodysplasia (HP:0002863)2.29929475
62Abnormality of the preputium (HP:0100587)2.28944342
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28024479
64Premature ovarian failure (HP:0008209)2.26023326
65Panhypogammaglobulinemia (HP:0003139)2.25225920
66Bone marrow hypocellularity (HP:0005528)2.25198750
67Acute encephalopathy (HP:0006846)2.25108235
68Hyperglycinemia (HP:0002154)2.24187696
69Entropion (HP:0000621)2.23840277
70Spastic paraparesis (HP:0002313)2.23793236
71Duplicated collecting system (HP:0000081)2.22218849
72Aplasia/Hypoplasia of the spleen (HP:0010451)2.21981014
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21633104
74Abnormal protein N-linked glycosylation (HP:0012347)2.21633104
75Abnormal protein glycosylation (HP:0012346)2.21633104
76Abnormal glycosylation (HP:0012345)2.21633104
77Increased intramyocellular lipid droplets (HP:0012240)2.20869376
78Abnormality of methionine metabolism (HP:0010901)2.19437360
79Multiple enchondromatosis (HP:0005701)2.17813071
80Abnormality of chromosome stability (HP:0003220)2.17636409
81Petechiae (HP:0000967)2.15036439
82Absent thumb (HP:0009777)2.14171319
83Cleft eyelid (HP:0000625)2.13416352
84Premature graying of hair (HP:0002216)2.13315739
85Abnormality of the ileum (HP:0001549)2.10798570
86Meckel diverticulum (HP:0002245)2.10463231
87Rough bone trabeculation (HP:0100670)2.09428445
88Abnormality of reticulocytes (HP:0004312)2.09053156
89Progressive external ophthalmoplegia (HP:0000590)2.08497903
90Abnormality of pyrimidine metabolism (HP:0004353)2.06235861
91Elevated erythrocyte sedimentation rate (HP:0003565)2.06161713
92Increased muscle lipid content (HP:0009058)2.05901988
93CNS hypomyelination (HP:0003429)2.05598559
94Lactic acidosis (HP:0003128)2.03940875
95Lymphoma (HP:0002665)2.03468810
96Neutropenia (HP:0001875)2.03464511
97Respiratory difficulties (HP:0002880)2.00807939
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00459796
99Dicarboxylic aciduria (HP:0003215)2.00459796
100Abnormal trabecular bone morphology (HP:0100671)1.99968992
101Lethargy (HP:0001254)1.99560872
102Abnormality of T cell physiology (HP:0011840)1.99540108
103Recurrent viral infections (HP:0004429)1.99349440
104Abnormality of the renal collecting system (HP:0004742)1.99192391
105Leukodystrophy (HP:0002415)1.99023702
106Amniotic constriction ring (HP:0009775)1.98392754
107Abnormality of placental membranes (HP:0011409)1.98392754
108Optic disc pallor (HP:0000543)1.97479607
109Generalized aminoaciduria (HP:0002909)1.96013658
110Cellular immunodeficiency (HP:0005374)1.93787341
111Ragged-red muscle fibers (HP:0003200)1.92276233
112Exercise intolerance (HP:0003546)1.91115993
113Abnormality of T cells (HP:0002843)1.90196927
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89557279
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88148859
116Medulloblastoma (HP:0002885)1.86679110
117Prolonged neonatal jaundice (HP:0006579)1.86549074
118Sloping forehead (HP:0000340)1.86096373
119Duodenal stenosis (HP:0100867)1.85538048
120Small intestinal stenosis (HP:0012848)1.85538048
121IgG deficiency (HP:0004315)1.85406591
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84815454
123Abnormality of serum amino acid levels (HP:0003112)1.82989383
124Self-mutilation (HP:0000742)1.82771150
125Hepatosplenomegaly (HP:0001433)1.82287052
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.82182456
127Carpal bone hypoplasia (HP:0001498)1.81666220
128Stenosis of the external auditory canal (HP:0000402)1.81479690
129Aplasia/Hypoplasia of the thymus (HP:0010515)1.81134087
130Trismus (HP:0000211)1.81046154
131Abnormality of renal resorption (HP:0011038)1.80543948
132Prostate neoplasm (HP:0100787)1.79590023
133Abnormal rod and cone electroretinograms (HP:0008323)1.78778721
134Secondary amenorrhea (HP:0000869)1.77961564
135Respiratory failure (HP:0002878)1.77273818
136Sparse eyelashes (HP:0000653)1.76590341
137Abnormal number of incisors (HP:0011064)1.76137396
138Abnormality of DNA repair (HP:0003254)1.75954138
139Agnosia (HP:0010524)1.75906297
140Poor head control (HP:0002421)1.75887029
141Gout (HP:0001997)1.75516347
142Patellar aplasia (HP:0006443)1.75216116
143Severe visual impairment (HP:0001141)1.75152986
144Chronic otitis media (HP:0000389)1.74828274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.02646881
2VRK24.67157775
3WEE13.44356941
4STK163.27207709
5TESK23.01206898
6EIF2AK13.00664941
7CDC72.93280570
8NME22.58458006
9MAP4K12.34070010
10VRK12.26374164
11PASK2.12784334
12EIF2AK32.02687480
13SMG11.99429078
14NME11.99137329
15TLK11.93464715
16ACVR1B1.93102906
17BRSK21.85188241
18NEK21.69683161
19SRPK11.65827473
20DYRK31.63005152
21PDK21.58759384
22MKNK11.57175816
23TGFBR11.55153254
24RPS6KB21.51887804
25MST41.49745166
26TSSK61.46775067
27BCKDK1.45650566
28KDR1.45596047
29CDK71.45175592
30PBK1.39982795
31AURKB1.39668830
32BTK1.37450729
33FLT31.37007276
34ATR1.33693244
35PLK11.31054460
36TTK1.29405334
37TAF11.28392958
38STK101.23560346
39PLK41.13321075
40BRSK11.12089122
41TEC1.08916215
42LRRK21.08300169
43STK41.08276252
44PIM21.06412782
45ZAP701.05977884
46DAPK11.05869675
47CDK191.05754340
48KIT1.02562546
49MAP3K81.00240914
50TESK10.99793850
51CDK40.99646883
52CCNB10.99429264
53AURKA0.96485039
54TRIM280.96370257
55TXK0.95919737
56PAK40.94497893
57CLK10.94019337
58MAP3K100.92838653
59NEK10.92698802
60CSF1R0.89134946
61EEF2K0.86753379
62LIMK10.85549486
63ILK0.85469622
64RPS6KA50.82427078
65RPS6KA40.82048934
66MAP2K30.80857888
67CHEK10.80533853
68NUAK10.80070530
69CHEK20.76971660
70SIK30.75322643
71MARK30.74599371
72ITK0.73192806
73UHMK10.72994945
74IRAK40.72495447
75PAK10.71720417
76PRKD30.71532656
77PIM10.69988040
78SCYL20.69628960
79CSNK2A20.65616409
80RIPK40.64838254
81CSNK2A10.64608471
82PRKCI0.63118586
83MAPKAPK50.60766618
84CDK80.60731305
85ALK0.59659523
86DYRK20.59500249
87EPHB10.57561539
88IRAK30.57532604
89PLK30.56638696
90LYN0.56122544
91CSNK1G30.55796752
92SYK0.54505877
93MAP3K30.53651055
94MAP3K110.53269494
95BLK0.51548686
96ATM0.50345932
97MST1R0.49888077
98ABL20.49590816
99TYK20.49278785
100GRK60.48968224
101CDK20.48853241
102LCK0.48035609
103JAK30.47245846
104TBK10.44769583
105MAPK110.44592267
106BRAF0.44165346
107EPHA20.44015022
108PIK3CG0.42650482
109STK390.41105300
110MAPKAPK30.40975710
111MYLK0.40898441
112DAPK30.40511495
113EIF2AK20.40346502
114IKBKB0.40073717
115ZAK0.39936615
116TAOK20.37438404
117CDK10.33654759
118MKNK20.33193466
119FGFR40.32480437
120AKT20.31865051
121IKBKE0.31576271
122MAPKAPK20.29555367
123ERN10.28641686
124RPS6KA60.28558400
125ADRBK20.25175156
126CSNK1G10.24901561
127CDK90.24516214
128MOS0.20522177

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76477659
2Ribosome_Homo sapiens_hsa030104.08106004
3Mismatch repair_Homo sapiens_hsa034303.91065134
4Proteasome_Homo sapiens_hsa030503.34596432
5Base excision repair_Homo sapiens_hsa034103.13288729
6RNA polymerase_Homo sapiens_hsa030202.93214079
7Spliceosome_Homo sapiens_hsa030402.90681007
8Homologous recombination_Homo sapiens_hsa034402.79402926
9Nucleotide excision repair_Homo sapiens_hsa034202.61625385
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57172839
11Pyrimidine metabolism_Homo sapiens_hsa002402.45656385
12Protein export_Homo sapiens_hsa030602.28979069
13Non-homologous end-joining_Homo sapiens_hsa034502.25732270
14One carbon pool by folate_Homo sapiens_hsa006702.18417501
15RNA transport_Homo sapiens_hsa030132.15076982
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95991656
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91775201
18Cell cycle_Homo sapiens_hsa041101.90943450
19Fanconi anemia pathway_Homo sapiens_hsa034601.71642018
20Basal transcription factors_Homo sapiens_hsa030221.51962459
21* RNA degradation_Homo sapiens_hsa030181.50681712
22Folate biosynthesis_Homo sapiens_hsa007901.48936783
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34726666
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32038836
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31301736
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31042220
27Parkinsons disease_Homo sapiens_hsa050121.25526530
28Purine metabolism_Homo sapiens_hsa002301.23423787
29Selenocompound metabolism_Homo sapiens_hsa004501.16715020
30Primary immunodeficiency_Homo sapiens_hsa053401.16291306
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.12901517
32Oxidative phosphorylation_Homo sapiens_hsa001901.08799294
33Sulfur relay system_Homo sapiens_hsa041221.06405387
34Systemic lupus erythematosus_Homo sapiens_hsa053221.05739793
35Fatty acid elongation_Homo sapiens_hsa000621.01404493
36Steroid biosynthesis_Homo sapiens_hsa001001.01077275
37Pentose phosphate pathway_Homo sapiens_hsa000301.00431500
38mRNA surveillance pathway_Homo sapiens_hsa030150.98491912
39p53 signaling pathway_Homo sapiens_hsa041150.96659008
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96646891
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.96471755
42Huntingtons disease_Homo sapiens_hsa050160.92496362
43Biosynthesis of amino acids_Homo sapiens_hsa012300.91632733
44Glutathione metabolism_Homo sapiens_hsa004800.89745367
45Epstein-Barr virus infection_Homo sapiens_hsa051690.84258121
46Antigen processing and presentation_Homo sapiens_hsa046120.77820698
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76816012
48Herpes simplex infection_Homo sapiens_hsa051680.75831749
49Fructose and mannose metabolism_Homo sapiens_hsa000510.75112869
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.73058658
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70732373
52Carbon metabolism_Homo sapiens_hsa012000.70635736
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70278210
54N-Glycan biosynthesis_Homo sapiens_hsa005100.66921252
55Phenylalanine metabolism_Homo sapiens_hsa003600.66229057
56Viral carcinogenesis_Homo sapiens_hsa052030.60667283
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57071938
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56505071
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55452930
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54922374
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54875719
62Metabolic pathways_Homo sapiens_hsa011000.54171010
63Alzheimers disease_Homo sapiens_hsa050100.52802546
64Pyruvate metabolism_Homo sapiens_hsa006200.52075642
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51414617
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49893606
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47469752
68Legionellosis_Homo sapiens_hsa051340.47029153
69Vitamin B6 metabolism_Homo sapiens_hsa007500.45968201
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45713346
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.44639210
72Graft-versus-host disease_Homo sapiens_hsa053320.43373618
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42131787
74Caffeine metabolism_Homo sapiens_hsa002320.39806913
75Peroxisome_Homo sapiens_hsa041460.38582636
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37953494
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.37174780
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36983808
79HTLV-I infection_Homo sapiens_hsa051660.36819691
80Arginine and proline metabolism_Homo sapiens_hsa003300.36206605
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36048635
82Measles_Homo sapiens_hsa051620.35833888
83Autoimmune thyroid disease_Homo sapiens_hsa053200.35277723
84Histidine metabolism_Homo sapiens_hsa003400.34571690
85Propanoate metabolism_Homo sapiens_hsa006400.34351869
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33019157
87Chemical carcinogenesis_Homo sapiens_hsa052040.31313928
88Arachidonic acid metabolism_Homo sapiens_hsa005900.30846559
89Hematopoietic cell lineage_Homo sapiens_hsa046400.29315409
90Sulfur metabolism_Homo sapiens_hsa009200.28804958
91Arginine biosynthesis_Homo sapiens_hsa002200.28411650
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.26936747
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26396515
94Viral myocarditis_Homo sapiens_hsa054160.25645463
95Linoleic acid metabolism_Homo sapiens_hsa005910.25083073
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24713905
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24235110
98Shigellosis_Homo sapiens_hsa051310.24234131
99Fatty acid metabolism_Homo sapiens_hsa012120.24119453
100Tyrosine metabolism_Homo sapiens_hsa003500.23124150
101Apoptosis_Homo sapiens_hsa042100.23082213
102Asthma_Homo sapiens_hsa053100.22063369
103Fatty acid degradation_Homo sapiens_hsa000710.21319563
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.21257879
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21134801
106beta-Alanine metabolism_Homo sapiens_hsa004100.20756935
107Retinol metabolism_Homo sapiens_hsa008300.20082829
108Notch signaling pathway_Homo sapiens_hsa043300.19907098
109Allograft rejection_Homo sapiens_hsa053300.19790070
110Alcoholism_Homo sapiens_hsa050340.19670024
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19579808
112Galactose metabolism_Homo sapiens_hsa000520.18009962
113Cardiac muscle contraction_Homo sapiens_hsa042600.17557059

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