DCST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.71103286
2cilium or flagellum-dependent cell motility (GO:0001539)9.42285088
3binding of sperm to zona pellucida (GO:0007339)9.34493603
4cell-cell recognition (GO:0009988)9.13314400
5epithelial cilium movement (GO:0003351)9.10123462
6acrosome assembly (GO:0001675)9.02868354
7cell wall macromolecule catabolic process (GO:0016998)8.93442001
8cell wall macromolecule metabolic process (GO:0044036)8.93442001
9plasma membrane fusion (GO:0045026)8.89149455
10axonemal dynein complex assembly (GO:0070286)8.79776883
11spermatid development (GO:0007286)8.60593048
12reproduction (GO:0000003)8.29470757
13motile cilium assembly (GO:0044458)7.93200131
14regulation of cilium movement (GO:0003352)7.92877793
15piRNA metabolic process (GO:0034587)7.68376562
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.53251245
17cilium movement (GO:0003341)7.30629938
18negative regulation of inclusion body assembly (GO:0090084)7.17811984
19male meiosis (GO:0007140)6.88446375
20single fertilization (GO:0007338)6.83693163
21synaptonemal complex organization (GO:0070193)6.81447917
22synaptonemal complex assembly (GO:0007130)6.64202746
23sperm capacitation (GO:0048240)6.60916124
24fertilization (GO:0009566)5.98427342
25spermatogenesis (GO:0007283)5.82491540
26male gamete generation (GO:0048232)5.80526885
27regulation of inclusion body assembly (GO:0090083)5.74748130
28male meiosis I (GO:0007141)5.57116262
29microtubule depolymerization (GO:0007019)5.55589708
30gamete generation (GO:0007276)5.34093773
31organic cation transport (GO:0015695)5.28335613
32cellular process involved in reproduction in multicellular organism (GO:0022412)4.87305795
33germ cell development (GO:0007281)4.86778918
34DNA methylation involved in gamete generation (GO:0043046)4.85093619
35regulation of microtubule-based movement (GO:0060632)4.72733609
36DNA strand renaturation (GO:0000733)4.72011405
37calcium ion-dependent exocytosis (GO:0017156)4.64373119
38phosphatidylethanolamine biosynthetic process (GO:0006646)4.63700202
39chromosome organization involved in meiosis (GO:0070192)4.62665739
40meiosis I (GO:0007127)4.60947792
41chromosome condensation (GO:0030261)4.58726876
42base-excision repair, AP site formation (GO:0006285)4.55567036
43ventricular system development (GO:0021591)4.45216944
44amino-acid betaine transport (GO:0015838)4.40574431
45carnitine transport (GO:0015879)4.40574431
46centriole assembly (GO:0098534)4.40366550
47regulation of cytokine production involved in inflammatory response (GO:1900015)4.35297413
48cell recognition (GO:0008037)4.35264658
49meiotic nuclear division (GO:0007126)4.33993621
50carnitine transmembrane transport (GO:1902603)4.29815723
51DNA packaging (GO:0006323)4.23088150
52glycerol ether metabolic process (GO:0006662)4.20563615
53multicellular organismal reproductive process (GO:0048609)4.20299310
54phosphatidylethanolamine metabolic process (GO:0046337)4.13279899
55GDP-mannose metabolic process (GO:0019673)4.10020704
56positive regulation of protein kinase C signaling (GO:0090037)4.05968963
57regulation of ARF GTPase activity (GO:0032312)4.05304973
58alkaloid metabolic process (GO:0009820)4.04816516
59chaperone-mediated protein complex assembly (GO:0051131)4.04795566
60seminiferous tubule development (GO:0072520)4.04030141
61regulation of spindle checkpoint (GO:0090231)3.88875286
62ether metabolic process (GO:0018904)3.85741820
63semaphorin-plexin signaling pathway (GO:0071526)3.82677500
64histone H4 deacetylation (GO:0070933)3.81968471
65protein polyglutamylation (GO:0018095)3.80933400
66centriole replication (GO:0007099)3.74958866
67rRNA methylation (GO:0031167)3.72673692
68microtubule severing (GO:0051013)3.71266071
69left/right pattern formation (GO:0060972)3.71183939
70meiotic cell cycle (GO:0051321)3.69536579
71alditol metabolic process (GO:0019400)3.63873461
72protein refolding (GO:0042026)3.60740319
73transepithelial transport (GO:0070633)3.56375090
74positive regulation of histone deacetylation (GO:0031065)3.53723802
75phosphatidylcholine biosynthetic process (GO:0006656)3.48202283
76protein carboxylation (GO:0018214)3.47486321
77peptidyl-glutamic acid carboxylation (GO:0017187)3.47486321
78regulation of skeletal muscle contraction (GO:0014819)3.46744724
79purinergic nucleotide receptor signaling pathway (GO:0035590)3.46355709
80negative regulation of cell aging (GO:0090344)3.45457432
81histone H3-K9 demethylation (GO:0033169)3.42118095
82sulfur amino acid catabolic process (GO:0000098)3.37748509
83sensory perception of taste (GO:0050909)3.35578513
84cell-cell junction maintenance (GO:0045217)3.34224688
85sexual reproduction (GO:0019953)3.33756905
86mRNA cleavage (GO:0006379)3.31867939
87cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.31416139
88genitalia morphogenesis (GO:0035112)3.27222725
89fructose metabolic process (GO:0006000)3.23619944
90multicellular organismal development (GO:0007275)3.22627937
91microtubule polymerization or depolymerization (GO:0031109)3.22222201
92interferon-gamma secretion (GO:0072643)3.17414755
93positive regulation of Rab GTPase activity (GO:0032851)3.17155068
94regulation of Rab GTPase activity (GO:0032313)3.17155068
954-hydroxyproline metabolic process (GO:0019471)3.16877609
96histone H3 deacetylation (GO:0070932)3.16089202
97polyol catabolic process (GO:0046174)3.13921231
98meiotic cell cycle process (GO:1903046)3.13095189
99detection of light stimulus involved in sensory perception (GO:0050962)3.11971150
100detection of light stimulus involved in visual perception (GO:0050908)3.11971150
101establishment of apical/basal cell polarity (GO:0035089)3.11947078
102carnitine shuttle (GO:0006853)3.11926515
103negative regulation of Rho protein signal transduction (GO:0035024)3.10780151
104single strand break repair (GO:0000012)3.07829478
105positive regulation of glycolytic process (GO:0045821)3.07061017
106G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06285513
107quaternary ammonium group transport (GO:0015697)3.03451400
108purine deoxyribonucleotide catabolic process (GO:0009155)3.01191095
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99294715
110glycerol metabolic process (GO:0006071)2.97446927
111rRNA catabolic process (GO:0016075)2.97081059
112urinary tract smooth muscle contraction (GO:0014848)2.95144820
113nucleoside diphosphate phosphorylation (GO:0006165)2.94684650
114mannose metabolic process (GO:0006013)2.94008637
115regulation of meiosis I (GO:0060631)2.93098959
116chromatin silencing (GO:0006342)2.92511649
117regulation of hydrogen peroxide metabolic process (GO:0010310)2.91546111
118spermatid nucleus differentiation (GO:0007289)2.90802173
119negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90256356
120CDP-diacylglycerol biosynthetic process (GO:0016024)2.89536773
121oxidative demethylation (GO:0070989)2.86304714
122synapsis (GO:0007129)2.85856769
123CDP-diacylglycerol metabolic process (GO:0046341)2.85170816
124nucleus organization (GO:0006997)2.84680400
125negative regulation of granulocyte differentiation (GO:0030853)2.84438750
126rRNA modification (GO:0000154)2.83408435
127protein complex localization (GO:0031503)2.82116744
128protein K11-linked deubiquitination (GO:0035871)2.81935138
129endothelial cell chemotaxis (GO:0035767)2.79619616
130phosphatidylglycerol biosynthetic process (GO:0006655)2.78106047
131monoubiquitinated protein deubiquitination (GO:0035520)2.78079551
132regulation of cilium assembly (GO:1902017)2.76881099
133nucleoside diphosphate catabolic process (GO:0009134)2.75546718
134protein localization to chromosome, centromeric region (GO:0071459)2.74592620
135protein localization to cilium (GO:0061512)2.72513615
136histone demethylation (GO:0016577)2.68917056
137fatty acid transmembrane transport (GO:1902001)2.67571344
138mitochondrion degradation (GO:0000422)2.66404207
139cellular response to arsenic-containing substance (GO:0071243)2.64458331
140lateral ventricle development (GO:0021670)2.63678572
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63486348
142nephron tubule morphogenesis (GO:0072078)2.62783479
143nephron epithelium morphogenesis (GO:0072088)2.62783479
144microtubule-based movement (GO:0007018)2.61965866
145regulation of chromatin binding (GO:0035561)2.61282307
146pentose metabolic process (GO:0019321)2.61270743
147establishment of skin barrier (GO:0061436)2.60452940
148peptidyl-glutamic acid modification (GO:0018200)2.58866918
149cellular response to ATP (GO:0071318)2.58335235
150negative regulation of fatty acid biosynthetic process (GO:0045717)2.57752222
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57687417
152UV protection (GO:0009650)2.56342433
153positive regulation of gastrulation (GO:2000543)2.56330843
154NAD biosynthetic process (GO:0009435)2.55698711
155poly(A)+ mRNA export from nucleus (GO:0016973)2.55676522
156retinoic acid receptor signaling pathway (GO:0048384)2.55387182
157retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55016248
158establishment of protein localization to Golgi (GO:0072600)2.54859948
159nucleosome disassembly (GO:0006337)2.53392473
160protein-DNA complex disassembly (GO:0032986)2.53392473
161axoneme assembly (GO:0035082)2.48454441
162polyamine biosynthetic process (GO:0006596)2.48270135
163mitotic sister chromatid cohesion (GO:0007064)2.47448008
164alditol phosphate metabolic process (GO:0052646)2.47240574
165RNA destabilization (GO:0050779)2.46885857
166phosphatidic acid metabolic process (GO:0046473)2.46859767
167phosphatidic acid biosynthetic process (GO:0006654)2.46859767
168sperm motility (GO:0030317)12.0454535
169fusion of sperm to egg plasma membrane (GO:0007342)11.7810057
170acrosome reaction (GO:0007340)10.6825410
171sperm-egg recognition (GO:0035036)10.0961045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.59885029
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.27240277
3EZH2_22144423_ChIP-Seq_EOC_Human3.95649748
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.57957452
5* LXR_22292898_ChIP-Seq_THP-1_Human3.03029099
6VDR_21846776_ChIP-Seq_THP-1_Human2.99108332
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.96942846
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.95367070
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92344486
10* P68_20966046_ChIP-Seq_HELA_Human2.86411287
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.68698197
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53756722
13RACK7_27058665_Chip-Seq_MCF-7_Human2.36918461
14SMC4_20622854_ChIP-Seq_HELA_Human2.35033173
15ELF1_20517297_ChIP-Seq_JURKAT_Human2.33293485
16* BCL6_27268052_Chip-Seq_Bcells_Human2.26648426
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.24108089
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22642100
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21495347
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20146473
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18453970
22VDR_22108803_ChIP-Seq_LS180_Human2.15783539
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11819440
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09190863
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.96036602
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.90912393
27* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89549245
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88687474
29CREB1_26743006_Chip-Seq_LNCaP_Human1.84263115
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83730077
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.83599583
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82056061
33ZNF274_21170338_ChIP-Seq_K562_Hela1.81878069
34MAF_26560356_Chip-Seq_TH2_Human1.80135106
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79735995
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79691546
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.79542878
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79225097
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77011790
40RARB_24833708_ChIP-Seq_LIVER_Mouse1.75094190
41STAT1_17558387_ChIP-Seq_HELA_Human1.72783023
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71407756
43* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.70118739
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69058798
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67550988
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.67273432
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64511849
48* FOXP1_21924763_ChIP-Seq_HESCs_Human1.63753472
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63372738
50ERA_21632823_ChIP-Seq_H3396_Human1.61110737
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60884669
52TCF7_22412390_ChIP-Seq_EML_Mouse1.59948336
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59818814
54SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57925362
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.57421883
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56767237
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.56022051
58KDM2B_26808549_Chip-Seq_DND41_Human1.56011758
59XRN2_22483619_ChIP-Seq_HELA_Human1.54903540
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.54391256
61SA1_27219007_Chip-Seq_Bcells_Human1.52816733
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.50558568
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.50512582
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.48311379
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46260623
66P300_27268052_Chip-Seq_Bcells_Human1.45333737
67P53_21459846_ChIP-Seq_SAOS-2_Human1.44802232
68WDR5_24793694_ChIP-Seq_LNCAP_Human1.44595020
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43725269
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.43378214
71VDR_24763502_ChIP-Seq_THP-1_Human1.43266875
72DROSHA_22980978_ChIP-Seq_HELA_Human1.41816838
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41022594
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.40371602
75MYC_22102868_ChIP-Seq_BL_Human1.40242969
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38313179
77CTCF_21964334_ChIP-Seq_BJAB-B_Human1.37290791
78CTCF_21964334_Chip-Seq_Bcells_Human1.36313383
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35731925
80FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34675645
81RAC3_21632823_ChIP-Seq_H3396_Human1.32001525
82GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.30752969
83CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29404311
84MAF_26560356_Chip-Seq_TH1_Human1.28761041
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28003376
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27395816
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.27333180
88KDM2B_26808549_Chip-Seq_K562_Human1.26788748
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26468521
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25329162
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23794304
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22593149
93ATF3_27146783_Chip-Seq_COLON_Human1.21339227
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.20885084
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20813308
96UTX_26944678_Chip-Seq_JUKART_Human1.19157055
97NCOR1_26117541_ChIP-Seq_K562_Human1.18713861
98* NANOG_20526341_ChIP-Seq_ESCs_Human1.17624549
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17204658
100CBP_20019798_ChIP-Seq_JUKART_Human1.16692473
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16692473
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16317308
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15891646
104FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15709690
105CTCF_20526341_ChIP-Seq_ESCs_Human1.14782349
106LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.14136824
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14016728
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.13148968
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12431729
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12335418
111CIITA_25753668_ChIP-Seq_RAJI_Human1.11279012
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11273611
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.11253847
114EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10710934
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10585879
116JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09996556
117ETV1_20927104_ChIP-Seq_GIST48_Human1.09042912
118ETS1_21867929_ChIP-Seq_TH2_Mouse1.09015647
119* TP53_22127205_ChIP-Seq_IMR90_Human1.08641894
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07447439
121GATA3_21867929_ChIP-Seq_TH1_Mouse1.06857233
122GF1_26923725_Chip-Seq_HPCs_Mouse1.06535680
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06159521
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.05751511
125E2F1_17053090_ChIP-ChIP_MCF-7_Human1.05674547
126TAF15_26573619_Chip-Seq_HEK293_Human1.05608016
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05265622
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05164913
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05162378
130P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04732018
131TAF2_19829295_ChIP-Seq_ESCs_Human1.04305053
132TET1_21451524_ChIP-Seq_MESCs_Mouse1.03894206
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03373767
134ESET_19884257_ChIP-Seq_ESCs_Mouse1.02866237
135RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02641649
136CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02304141
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02039992
138* MYC_19829295_ChIP-Seq_ESCs_Human1.01763170
139FLI1_21867929_ChIP-Seq_CD8_Mouse1.01402002
140PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01047387
141ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00751341
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00526218
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00003936
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.99973624
145NFYB_21822215_ChIP-Seq_K562_Human0.99923134
146SPI1_26923725_Chip-Seq_HPCs_Mouse0.99103982
147PHF8_20622853_ChIP-Seq_HELA_Human0.97949081
148CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97769876
149REST_21632747_ChIP-Seq_MESCs_Mouse0.97746148
150* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97306148
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97027267
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.97001999
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96895925
154TBL1_22424771_ChIP-Seq_293T_Human0.96835980
155ZNF263_19887448_ChIP-Seq_K562_Human0.96472418
156RBPJ_21746931_ChIP-Seq_IB4_Human0.96359264
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96196005
158BCOR_27268052_Chip-Seq_Bcells_Human0.95969497
159TP63_22573176_ChIP-Seq_HFKS_Human0.95381842
160RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94057071
161KDM2B_26808549_Chip-Seq_REH_Human0.93070927
162ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92752970
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92697762
164KLF4_19829295_ChIP-Seq_ESCs_Human0.90724490
165ERG_20517297_ChIP-Seq_VCAP_Human0.90258511
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.90087192
167SMAD4_21741376_ChIP-Seq_EPCs_Human0.89814484
168* PHF8_20622854_ChIP-Seq_HELA_Human0.89778301
169SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89176342
170* E2F1_20622854_ChIP-Seq_HELA_Human0.88949504
171CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88391498
172OCT4_19829295_ChIP-Seq_ESCs_Human0.88289785
173OCT4_18555785_Chip-Seq_ESCs_Mouse0.88053292
174* CTCF_27219007_Chip-Seq_Bcells_Human0.87983156
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87940897
176TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87756314
177CRX_20693478_ChIP-Seq_RETINA_Mouse0.87628370
178NANOG_18555785_Chip-Seq_ESCs_Mouse0.87542941
179LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87313573
180SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86931149
181OCT4_20526341_ChIP-Seq_ESCs_Human0.85875319
182PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85453543
183SOX11_22085726_ChIP-Seq_ESNs_Mouse0.85256198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.58338892
2MP0003698_abnormal_male_reproductive5.39857042
3MP0005409_darkened_coat_color4.83805049
4MP0001929_abnormal_gametogenesis4.78990178
5MP0005670_abnormal_white_adipose4.25924104
6MP0008877_abnormal_DNA_methylation4.12680538
7MP0005171_absent_coat_pigmentation3.21914659
8MP0002210_abnormal_sex_determination3.19249341
9MP0005174_abnormal_tail_pigmentation3.11312106
10MP0002161_abnormal_fertility/fecundity3.05420710
11MP0001986_abnormal_taste_sensitivity2.86472493
12MP0001145_abnormal_male_reproductive2.67843420
13MP0010030_abnormal_orbit_morphology2.55770761
14MP0003136_yellow_coat_color2.52862176
15MP0002249_abnormal_larynx_morphology2.47680825
16MP0001661_extended_life_span2.31725421
17MP0000653_abnormal_sex_gland2.30142717
18MP0004381_abnormal_hair_follicle2.28663792
19MP0008875_abnormal_xenobiotic_pharmacok2.27028423
20MP0005083_abnormal_biliary_tract2.22317907
21MP0000678_abnormal_parathyroid_gland2.16033967
22MP0003950_abnormal_plasma_membrane2.11923365
23MP0000579_abnormal_nail_morphology2.02320294
24MP0005410_abnormal_fertilization14.0500903
25MP0003453_abnormal_keratinocyte_physiol1.98287762
26MP0003705_abnormal_hypodermis_morpholog1.96073793
27MP0005423_abnormal_somatic_nervous1.92618603
28MP0000383_abnormal_hair_follicle1.80266311
29MP0005623_abnormal_meninges_morphology1.75392686
30MP0002160_abnormal_reproductive_system1.74077246
31MP0002132_abnormal_respiratory_system1.69189899
32MP0001873_stomach_inflammation1.58290494
33MP0002653_abnormal_ependyma_morphology1.58128338
34MP0003646_muscle_fatigue1.51950053
35MP0004130_abnormal_muscle_cell1.51438470
36MP0005666_abnormal_adipose_tissue1.50943691
37MP0003718_maternal_effect1.48275521
38MP0003878_abnormal_ear_physiology1.47552295
39MP0005377_hearing/vestibular/ear_phenot1.47552295
40MP0009053_abnormal_anal_canal1.42779648
41MP0005501_abnormal_skin_physiology1.38939038
42MP0001346_abnormal_lacrimal_gland1.38847598
43MP0002098_abnormal_vibrissa_morphology1.38587174
44MP0003172_abnormal_lysosome_physiology1.31777678
45MP0000462_abnormal_digestive_system1.30985465
46MP0003111_abnormal_nucleus_morphology1.30500969
47MP0000751_myopathy1.21361602
48MP0002933_joint_inflammation1.20777987
49MP0001849_ear_inflammation1.19738765
50MP0003693_abnormal_embryo_hatching1.19658561
51MP0005058_abnormal_lysosome_morphology1.17687971
52MP0005365_abnormal_bile_salt1.16033325
53MP0004264_abnormal_extraembryonic_tissu1.13685290
54MP0005330_cardiomyopathy1.12667483
55MP0004233_abnormal_muscle_weight1.10548786
56MP0005394_taste/olfaction_phenotype1.10456934
57MP0005499_abnormal_olfactory_system1.10456934
58MP0000467_abnormal_esophagus_morphology1.06080693
59MP0005248_abnormal_Harderian_gland1.06004391
60MP0006292_abnormal_olfactory_placode1.05255608
61MP0008789_abnormal_olfactory_epithelium1.04149078
62MP0001502_abnormal_circadian_rhythm1.03661108
63MP0005375_adipose_tissue_phenotype1.03457487
64MP0002102_abnormal_ear_morphology1.02859071
65MP0001727_abnormal_embryo_implantation1.02649775
66MP0001765_abnormal_ion_homeostasis1.01187224
67MP0000015_abnormal_ear_pigmentation1.00675257
68MP0009115_abnormal_fat_cell0.99135350
69MP0001348_abnormal_lacrimal_gland0.96907746
70MP0005389_reproductive_system_phenotype0.96131090
71MP0000920_abnormal_myelination0.95642480
72MP0000569_abnormal_digit_pigmentation0.94187742
73MP0000377_abnormal_hair_follicle0.93825586
74MP0003315_abnormal_perineum_morphology0.92923088
75MP0005076_abnormal_cell_differentiation0.91791148
76MP0002269_muscular_atrophy0.90428477
77MP0000367_abnormal_coat/_hair0.89456505
78MP0001324_abnormal_eye_pigmentation0.88714211
79MP0010678_abnormal_skin_adnexa0.85690789
80MP0009931_abnormal_skin_appearance0.85669675
81MP0003329_amyloid_beta_deposits0.84892893
82MP0002075_abnormal_coat/hair_pigmentati0.82913589
83MP0004270_analgesia0.81809144
84MP0002282_abnormal_trachea_morphology0.80941414
85MP0008995_early_reproductive_senescence0.79446900
86MP0010094_abnormal_chromosome_stability0.79250943
87MP0002822_catalepsy0.78599841
88MP0008057_abnormal_DNA_replication0.77694959
89MP0004197_abnormal_fetal_growth/weight/0.77047054
90MP0009840_abnormal_foam_cell0.76843244
91MP0009384_cardiac_valve_regurgitation0.76547369
92MP0005451_abnormal_body_composition0.75034804
93MP0001216_abnormal_epidermal_layer0.74018061
94MP0004742_abnormal_vestibular_system0.73865421
95MP0004019_abnormal_vitamin_homeostasis0.72898462
96MP0003045_fibrosis0.70908957
97MP0000470_abnormal_stomach_morphology0.70409258
98MP0000026_abnormal_inner_ear0.70046912
99MP0005395_other_phenotype0.69282414
100MP0002118_abnormal_lipid_homeostasis0.68779677
101MP0004147_increased_porphyrin_level0.68722838
102MP0004947_skin_inflammation0.68353595
103MP0000537_abnormal_urethra_morphology0.68170267
104MP0003699_abnormal_female_reproductive0.67988289
105MP0009046_muscle_twitch0.67679836
106MP0003656_abnormal_erythrocyte_physiolo0.67214410
107MP0000750_abnormal_muscle_regeneration0.67196963
108MP0005332_abnormal_amino_acid0.67192186
109MP0009278_abnormal_bone_marrow0.67088307
110MP0009643_abnormal_urine_homeostasis0.66567328
111MP0010771_integument_phenotype0.66567109
112MP0003283_abnormal_digestive_organ0.66029988
113MP0005253_abnormal_eye_physiology0.63959186
114MP0002932_abnormal_joint_morphology0.63472992
115MP0008058_abnormal_DNA_repair0.63372603
116MP0003011_delayed_dark_adaptation0.63234329
117MP0000358_abnormal_cell_content/0.62899179
118MP0002971_abnormal_brown_adipose0.62490488
119MP0002796_impaired_skin_barrier0.62150062
120MP0001730_embryonic_growth_arrest0.58852823
121MP0000013_abnormal_adipose_tissue0.57592940
122MP0004185_abnormal_adipocyte_glucose0.57174042
123MP0008961_abnormal_basal_metabolism0.56956724
124MP0000003_abnormal_adipose_tissue0.56773664
125MP0003936_abnormal_reproductive_system0.54649495
126MP0001764_abnormal_homeostasis0.54505565
127MP0002909_abnormal_adrenal_gland0.54434559
128MP0010329_abnormal_lipoprotein_level0.54432768
129MP0005391_vision/eye_phenotype0.53511361
130MP0005334_abnormal_fat_pad0.53414312
131MP0008260_abnormal_autophagy0.52954055
132MP0002970_abnormal_white_adipose0.52931418
133MP0005360_urolithiasis0.52071105
134MP0005257_abnormal_intraocular_pressure0.50689718
135MP0000604_amyloidosis0.50096738
136MP0001486_abnormal_startle_reflex0.47343951
137MP0003690_abnormal_glial_cell0.47071040
138MP0005636_abnormal_mineral_homeostasis0.47011601
139MP0006036_abnormal_mitochondrial_physio0.46747745
140MP0003879_abnormal_hair_cell0.46501480
141MP0003567_abnormal_fetal_cardiomyocyte0.46232709
142MP0000647_abnormal_sebaceous_gland0.45519052
143MP0004885_abnormal_endolymph0.43472120
144MP0004957_abnormal_blastocyst_morpholog0.43075583
145MP0003806_abnormal_nucleotide_metabolis0.42689195
146MP0001293_anophthalmia0.41928432
147MP0008438_abnormal_cutaneous_collagen0.41060514
148MP0002295_abnormal_pulmonary_circulatio0.40899766
149MP0001672_abnormal_embryogenesis/_devel0.40377997
150MP0005380_embryogenesis_phenotype0.40377997
151MP0003115_abnormal_respiratory_system0.39846415
152MP0002876_abnormal_thyroid_physiology0.39547331
153MP0001440_abnormal_grooming_behavior0.38567668
154MP0001485_abnormal_pinna_reflex0.37699703
155MP0005448_abnormal_energy_balance0.37669974
156MP0001851_eye_inflammation0.37394216
157MP0002229_neurodegeneration0.35680282
158MP0003221_abnormal_cardiomyocyte_apopto0.35580166
159MP0001756_abnormal_urination0.34795599
160MP0002234_abnormal_pharynx_morphology0.33030732
161MP0001963_abnormal_hearing_physiology0.32865498
162MP0005551_abnormal_eye_electrophysiolog0.32319288
163MP0005310_abnormal_salivary_gland0.31314189
164MP0000432_abnormal_head_morphology0.31067587
165MP0003634_abnormal_glial_cell0.30819202
166MP0009672_abnormal_birth_weight0.30002978
167MP0003984_embryonic_growth_retardation0.29564347

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)7.95472880
2Abnormal respiratory motile cilium morphology (HP:0005938)7.95472880
3Abnormal respiratory motile cilium physiology (HP:0012261)7.95398307
4Infertility (HP:0000789)6.52167598
5Rhinitis (HP:0012384)6.41338085
6Chronic bronchitis (HP:0004469)6.14798569
7Abnormal ciliary motility (HP:0012262)6.06345571
8Nasal polyposis (HP:0100582)5.22348885
9Male infertility (HP:0003251)5.02921985
10Testicular atrophy (HP:0000029)4.37498451
11Abnormality of the nasal mucosa (HP:0000433)4.12571441
12Impulsivity (HP:0100710)4.01910428
13Abnormal spermatogenesis (HP:0008669)4.01238082
14Facial hemangioma (HP:0000329)4.01063723
15Severe visual impairment (HP:0001141)3.82279607
16Rib fusion (HP:0000902)3.77263791
17Cervical subluxation (HP:0003308)3.72012695
18Bronchitis (HP:0012387)3.70013222
19Bronchiectasis (HP:0002110)3.64425266
20Attenuation of retinal blood vessels (HP:0007843)3.62436002
21Nephronophthisis (HP:0000090)3.59703827
22Anteriorly placed anus (HP:0001545)3.59006961
23Thin bony cortex (HP:0002753)3.58841262
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.38510988
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.38510988
26Abnormality of the aortic arch (HP:0012303)3.36114658
27Delayed epiphyseal ossification (HP:0002663)3.29907583
28Bony spicule pigmentary retinopathy (HP:0007737)3.24888578
29Chronic hepatic failure (HP:0100626)3.21601195
30Spastic tetraparesis (HP:0001285)3.15301793
31Atelectasis (HP:0100750)3.10693836
32Enlarged epiphyses (HP:0010580)2.97425483
33Abnormality of the renal medulla (HP:0100957)2.84749768
34Recurrent otitis media (HP:0000403)2.84693724
35Mesangial abnormality (HP:0001966)2.80056811
36Choroideremia (HP:0001139)2.78417619
37Tubular atrophy (HP:0000092)2.73443399
38Turricephaly (HP:0000262)2.68383054
39Abnormality of the corticospinal tract (HP:0002492)2.67819850
40Absent thumb (HP:0009777)2.65245902
41Neurofibrillary tangles (HP:0002185)2.64558682
42Vitreoretinal degeneration (HP:0000655)2.64437056
43Azoospermia (HP:0000027)2.62672735
44Nasolacrimal duct obstruction (HP:0000579)2.62181173
45Abnormality of midbrain morphology (HP:0002418)2.56927119
46Molar tooth sign on MRI (HP:0002419)2.56927119
47Poikiloderma (HP:0001029)2.52655875
48Ulnar bowing (HP:0003031)2.51052979
49Intellectual disability, moderate (HP:0002342)2.48426709
50Recurrent sinusitis (HP:0011108)2.43999290
51Fetal akinesia sequence (HP:0001989)2.43600485
52Popliteal pterygium (HP:0009756)2.42464085
53Tubulointerstitial abnormality (HP:0001969)2.41439833
54Tubulointerstitial fibrosis (HP:0005576)2.40921499
55Insidious onset (HP:0003587)2.38901162
56Termporal pattern (HP:0011008)2.38901162
57Annular pancreas (HP:0001734)2.38279819
58Hemorrhage of the eye (HP:0011885)2.37203949
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34358844
60Occipital encephalocele (HP:0002085)2.33102074
61Abnormality of the costochondral junction (HP:0000919)2.32779926
62Broad face (HP:0000283)2.31777750
63Joint stiffness (HP:0001387)2.31272647
64Macular degeneration (HP:0000608)2.31042386
65Joint hemorrhage (HP:0005261)2.28589324
66Bell-shaped thorax (HP:0001591)2.28249670
67Widely patent fontanelles and sutures (HP:0004492)2.25982876
68Malnutrition (HP:0004395)2.24678695
69Capillary hemangiomas (HP:0005306)2.24423663
70Flattened epiphyses (HP:0003071)2.22386266
71Flat capital femoral epiphysis (HP:0003370)2.15080413
72Renal Fanconi syndrome (HP:0001994)2.14956115
73Intestinal fistula (HP:0100819)2.14494835
74Prolonged partial thromboplastin time (HP:0003645)2.12790216
75Gonadotropin excess (HP:0000837)2.10136473
76Coronal craniosynostosis (HP:0004440)2.09819777
77Aplasia of the musculature (HP:0100854)2.09223533
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08281649
79Absent epiphyses (HP:0010577)2.08281649
80Tubulointerstitial nephritis (HP:0001970)2.06966730
81Recurrent bronchitis (HP:0002837)2.06822992
82J-shaped sella turcica (HP:0002680)2.06463826
83Cystic liver disease (HP:0006706)2.06218439
84Cerebral inclusion bodies (HP:0100314)2.05619911
85Metaphyseal cupping (HP:0003021)2.04722410
86Abnormality of the lacrimal duct (HP:0011481)2.03577237
87Rectovaginal fistula (HP:0000143)2.03093974
88Rectal fistula (HP:0100590)2.03093974
89Retrobulbar optic neuritis (HP:0100654)2.02897830
90Optic neuritis (HP:0100653)2.02897830
91Hypoplastic ischia (HP:0003175)2.01437416
92Absent/shortened dynein arms (HP:0200106)12.2204512
93Dynein arm defect of respiratory motile cilia (HP:0012255)12.2204512
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8847462
95Abnormal rod and cone electroretinograms (HP:0008323)1.98401544
96Vaginal fistula (HP:0004320)1.97460110
97Abnormality of the renal cortex (HP:0011035)1.96230150
98Cholecystitis (HP:0001082)1.92262597
99Abnormal gallbladder physiology (HP:0012438)1.92262597
100Obstructive sleep apnea (HP:0002870)1.89371910
101Thin ribs (HP:0000883)1.89265403
102Flat acetabular roof (HP:0003180)1.89085611
103Zonular cataract (HP:0010920)1.88503824
104Abnormality of the hepatic vasculature (HP:0006707)1.87705122
105Dyschromatopsia (HP:0007641)1.87052146
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86411423
107Abnormal drinking behavior (HP:0030082)1.84014307
108Polydipsia (HP:0001959)1.84014307
109Lip pit (HP:0100267)1.82102491
110High anterior hairline (HP:0009890)1.81242957
111Difficulty climbing stairs (HP:0003551)1.80397476
112Absent radius (HP:0003974)1.79623854
113Hypophosphatemic rickets (HP:0004912)1.79565620
114Abnormality of renal excretion (HP:0011036)1.78035455
115Pancreatic fibrosis (HP:0100732)1.77354259
116Abnormality of lateral ventricle (HP:0030047)1.76959393
117Short ribs (HP:0000773)1.76703482
118Abnormality of incisor morphology (HP:0011063)1.76259476
119Urinary bladder sphincter dysfunction (HP:0002839)1.75823482
120Choanal stenosis (HP:0000452)1.72974912
121Broad distal phalanx of finger (HP:0009836)1.71190932
122Abnormality of permanent molar morphology (HP:0011071)1.70567822
123Abnormality of the dental root (HP:0006486)1.70567822
124Taurodontia (HP:0000679)1.70567822
125Abnormality of molar (HP:0011077)1.67883858
126Abnormality of molar morphology (HP:0011070)1.67883858
127Insulin-resistant diabetes mellitus (HP:0000831)1.67760632
128Asymmetric septal hypertrophy (HP:0001670)1.67678758
129Abnormality of the fingertips (HP:0001211)1.67474492
130Congenital stationary night blindness (HP:0007642)1.67241683
131Orchitis (HP:0100796)1.65696655
132Abnormal biliary tract physiology (HP:0012439)1.65554741
133Bile duct proliferation (HP:0001408)1.65554741
134Bundle branch block (HP:0011710)1.65346276
135Pigmentary retinal degeneration (HP:0001146)1.65278918
136Villous atrophy (HP:0011473)1.64838886
137Abnormality of small intestinal villus morphology (HP:0011472)1.64838886
138Alacrima (HP:0000522)1.64680377
139Breast hypoplasia (HP:0003187)1.64408725
140Renal dysplasia (HP:0000110)1.63317373
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63127847
142Patellar aplasia (HP:0006443)1.62941986
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.62206325
144Neoplasm of the heart (HP:0100544)1.61863470
145Spastic gait (HP:0002064)1.59514025
146Impaired vibration sensation in the lower limbs (HP:0002166)1.56635640
147Decreased central vision (HP:0007663)1.55798484
148Abnormality of the dental pulp (HP:0006479)1.50809372
149Abnormality of the lower motor neuron (HP:0002366)1.46622660
150Facial shape deformation (HP:0011334)1.44800693
151Potter facies (HP:0002009)1.44800693
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.43828397
153Abnormal urine output (HP:0012590)1.43674234
154Nephropathy (HP:0000112)1.42606556
155Hyporeflexia of lower limbs (HP:0002600)1.41899475
156Ureteral duplication (HP:0000073)1.41722297
157Vascular calcification (HP:0004934)1.41652305
158Prolonged neonatal jaundice (HP:0006579)1.40193055
159Stage 5 chronic kidney disease (HP:0003774)1.38642253
160Sensory axonal neuropathy (HP:0003390)1.37153145
161Congenital hepatic fibrosis (HP:0002612)1.37136199
162Urinary urgency (HP:0000012)1.34096079
163Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.33931585
164Fibular hypoplasia (HP:0003038)1.33930603
165Microglossia (HP:0000171)1.32628221
166Personality changes (HP:0000751)1.32374005
167Deformed sella turcica (HP:0002681)1.31368517
168Hypoplasia of the uterus (HP:0000013)1.31068653
169Hypercholesterolemia (HP:0003124)1.29676912
170Amyloidosis (HP:0011034)1.29540574
171Glucose intolerance (HP:0000833)1.29233702
172Short phalanx of the thumb (HP:0009660)1.26523409
173Heterotopia (HP:0002282)1.26082337
174Thyroid-stimulating hormone excess (HP:0002925)1.25766567
175Hypertriglyceridemia (HP:0002155)1.25283389
176Pachygyria (HP:0001302)1.24418376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.84648755
2PDK36.84648755
3MAP4K25.21063500
4TESK15.17196158
5PNCK4.81007201
6PRKD34.59430872
7PDK24.37743159
8ICK3.84351297
9STK392.98992528
10MAP3K62.80596562
11SMG12.42080754
12TRIB32.26574720
13ERN12.05444875
14WNK41.90443170
15CAMK1G1.86978968
16SIK11.82626471
17PTK2B1.81704289
18WEE11.77057111
19EPHB11.67457109
20NEK21.65802106
21MARK21.60185040
22PKN21.52255148
23TTK1.49760788
24VRK21.49236217
25TNK21.47904218
26STK161.41009677
27ACVR1B1.35742645
28INSRR1.32809860
29MAP3K71.32278576
30STK381.31950063
31BUB11.24061312
32MUSK1.21087831
33PDK11.17323737
34IRAK11.16116927
35PRKD21.08921793
36TNIK1.07721926
37DYRK1B1.05840090
38OXSR11.01567944
39PAK61.00420868
40MAP2K30.99916470
41MST1R0.98777762
42PDPK10.98536080
43DYRK30.95065700
44ARAF0.92856358
45TAF10.92173836
46PTK60.85320646
47MAP2K60.84321232
48ZAK0.83513997
49BMX0.83349605
50BRSK20.80310377
51CAMK1D0.77827181
52MAP3K30.77460117
53MAP2K40.77307777
54CAMKK10.76702537
55PAK10.75827188
56GRK60.73375140
57MELK0.72832852
58MAP4K10.69934733
59BLK0.67797906
60CAMKK20.67132898
61WNK10.66067562
62LRRK20.62932177
63CDK70.62881992
64RPS6KL10.62860495
65RPS6KC10.62860495
66EEF2K0.62115277
67STK110.61879267
68RPS6KA20.61508748
69TAOK10.61214726
70EPHA20.61056668
71CDK120.60705269
72NEK60.60274349
73MET0.59718569
74PRKAA10.58902525
75RPS6KA60.57881835
76EPHB20.56190331
77MAP3K20.55962475
78STK100.55906101
79STK30.55823160
80HIPK20.55447910
81TYRO30.54857438
82CHEK20.54552274
83BRAF0.54348862
84TBK10.53850473
85ZAP700.52417181
86PLK40.51856464
87RIPK10.51446123
88EPHA30.50347861
89CCNB10.49495749
90TYK20.49343822
91RET0.46565122
92CDK80.46069556
93PASK0.45848179
94DDR20.45777503
95CHUK0.45620616
96MAPK150.44696210
97MTOR0.44493146
98TESK20.43669218
99ERBB20.42616826
100CHEK10.40501875
101CAMK10.39824626
102SIK30.39082562
103PRKAA20.37217369
104EPHA40.37194097
105CDK40.36867811
106CDC42BPA0.35842738
107NUAK10.35030765
108PLK10.33938447
109BRSK10.33664837
110CDK90.32872119
111CDK190.31955731
112PRKG20.31880694
113DYRK1A0.31576889
114LMTK20.31432603
115MARK10.31429564
116KSR20.31322310
117FER0.30698275
118CDK150.30582887
119IRAK40.30075660
120RPS6KA10.29615175
121SGK30.29397998
122PRKD10.28445700
123MAPK10.28340077
124PKN10.28275694
125BTK0.27945895
126WNK30.27854196
127JAK30.26567723
128CDK180.26107676
129MAP3K80.25925401
130NTRK10.24510519
131CDK11A0.24137885
132CDK140.23635629
133AURKA0.23135519
134IRAK20.22007856
135STK38L0.21693034
136FGFR40.21666327
137AKT30.20457926
138PAK20.20457021
139PAK40.20405220
140PRKCG0.20091845
141FGFR20.19284355
142DYRK20.17754607
143CDK10.17226232
144PAK30.15288354
145MAP3K40.15024031
146CSNK1E0.12050412
147ATM0.11869730
148NME10.11623139
149GSK3B0.10695986
150MAPK80.10167355
151ATR0.10053123
152CDK30.09076911
153CDK60.08966254
154PRKCZ0.08502084
155CAMK2B0.07868721
156PRKCI0.06653670
157CSNK2A10.06333349
158PRKACG0.06086438
159CSK0.06041318
160CSNK1D0.05107474
161TSSK60.04545550

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.00040265
2Vitamin B6 metabolism_Homo sapiens_hsa007504.20626795
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.11437446
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.90228949
5Fatty acid biosynthesis_Homo sapiens_hsa000613.73892760
6Propanoate metabolism_Homo sapiens_hsa006403.27158097
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26285462
8Linoleic acid metabolism_Homo sapiens_hsa005913.24942237
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.99314451
10Notch signaling pathway_Homo sapiens_hsa043302.70398182
11Pyruvate metabolism_Homo sapiens_hsa006202.59276261
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.39845765
13Glycerophospholipid metabolism_Homo sapiens_hsa005642.32455632
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32082502
15Phenylalanine metabolism_Homo sapiens_hsa003602.29648821
16Fat digestion and absorption_Homo sapiens_hsa049752.29306941
17PPAR signaling pathway_Homo sapiens_hsa033202.19307566
18Pentose phosphate pathway_Homo sapiens_hsa000302.19224478
19Fructose and mannose metabolism_Homo sapiens_hsa000512.18260920
20Lysine degradation_Homo sapiens_hsa003102.17795160
21Glycerolipid metabolism_Homo sapiens_hsa005612.16431824
22Ether lipid metabolism_Homo sapiens_hsa005652.15393584
23Other glycan degradation_Homo sapiens_hsa005112.07249397
24Fatty acid metabolism_Homo sapiens_hsa012121.96522981
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.94019285
26Glucagon signaling pathway_Homo sapiens_hsa049221.93132775
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91370491
28Base excision repair_Homo sapiens_hsa034101.83521205
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78389998
30Mineral absorption_Homo sapiens_hsa049781.71579008
31Carbon metabolism_Homo sapiens_hsa012001.63136131
32Oocyte meiosis_Homo sapiens_hsa041141.59159489
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58325806
34Fatty acid degradation_Homo sapiens_hsa000711.54578129
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.51381992
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44661028
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.42062317
38Arginine biosynthesis_Homo sapiens_hsa002201.40634114
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.39568491
40Proteasome_Homo sapiens_hsa030501.37867255
41Basal transcription factors_Homo sapiens_hsa030221.35175914
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33755397
43Regulation of autophagy_Homo sapiens_hsa041401.33019862
44RNA transport_Homo sapiens_hsa030131.32260043
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30979932
46Basal cell carcinoma_Homo sapiens_hsa052171.21520319
47Arachidonic acid metabolism_Homo sapiens_hsa005901.19031173
48Fatty acid elongation_Homo sapiens_hsa000621.16567313
49Histidine metabolism_Homo sapiens_hsa003401.14415758
50Glutathione metabolism_Homo sapiens_hsa004801.13892495
51Fanconi anemia pathway_Homo sapiens_hsa034601.12683391
52Acute myeloid leukemia_Homo sapiens_hsa052211.12584785
53Arginine and proline metabolism_Homo sapiens_hsa003301.09674808
54Sphingolipid metabolism_Homo sapiens_hsa006001.08822616
55Ovarian steroidogenesis_Homo sapiens_hsa049131.08667553
56Purine metabolism_Homo sapiens_hsa002301.07043697
57Choline metabolism in cancer_Homo sapiens_hsa052311.07033646
58Tyrosine metabolism_Homo sapiens_hsa003501.06987614
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06131204
60Dorso-ventral axis formation_Homo sapiens_hsa043201.05967921
61Adipocytokine signaling pathway_Homo sapiens_hsa049201.05418897
62Selenocompound metabolism_Homo sapiens_hsa004501.01475744
63AMPK signaling pathway_Homo sapiens_hsa041520.98478139
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97533077
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96525213
66Inositol phosphate metabolism_Homo sapiens_hsa005620.92072712
67Huntingtons disease_Homo sapiens_hsa050160.89432047
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86000946
69Taste transduction_Homo sapiens_hsa047420.85806237
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84717996
71Antigen processing and presentation_Homo sapiens_hsa046120.84353339
72Protein digestion and absorption_Homo sapiens_hsa049740.84165528
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83862512
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80305523
75mTOR signaling pathway_Homo sapiens_hsa041500.80103277
76ABC transporters_Homo sapiens_hsa020100.79074637
77VEGF signaling pathway_Homo sapiens_hsa043700.79073789
78Phototransduction_Homo sapiens_hsa047440.78779079
79Lysosome_Homo sapiens_hsa041420.74928952
80Steroid biosynthesis_Homo sapiens_hsa001000.73825845
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73469642
82Renin-angiotensin system_Homo sapiens_hsa046140.73064351
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72462839
84Biosynthesis of amino acids_Homo sapiens_hsa012300.71486921
85Pyrimidine metabolism_Homo sapiens_hsa002400.70826836
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69524879
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69497558
88Metabolic pathways_Homo sapiens_hsa011000.66139923
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63981857
90Olfactory transduction_Homo sapiens_hsa047400.63043446
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61617099
92Sulfur metabolism_Homo sapiens_hsa009200.61426629
93Vitamin digestion and absorption_Homo sapiens_hsa049770.61224246
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59969037
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59013776
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58974669
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58558117
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57939382
99Autoimmune thyroid disease_Homo sapiens_hsa053200.57432807
100Thyroid hormone synthesis_Homo sapiens_hsa049180.56229874
101Pancreatic secretion_Homo sapiens_hsa049720.53578307
102RNA polymerase_Homo sapiens_hsa030200.52893424
103Hedgehog signaling pathway_Homo sapiens_hsa043400.52378211
104Peroxisome_Homo sapiens_hsa041460.52217842
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50083143
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50022316
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.49813846
108Amphetamine addiction_Homo sapiens_hsa050310.49810416
109Axon guidance_Homo sapiens_hsa043600.49391936
110Retinol metabolism_Homo sapiens_hsa008300.48828837
111Renin secretion_Homo sapiens_hsa049240.48814119
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48086672
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47553663
114Cardiac muscle contraction_Homo sapiens_hsa042600.46860553
115Mismatch repair_Homo sapiens_hsa034300.45840511
116mRNA surveillance pathway_Homo sapiens_hsa030150.44858681
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.44834663
118Hepatitis C_Homo sapiens_hsa051600.43937483
119Collecting duct acid secretion_Homo sapiens_hsa049660.42708799
120Non-small cell lung cancer_Homo sapiens_hsa052230.42254899
121Bile secretion_Homo sapiens_hsa049760.42226023
122Endocytosis_Homo sapiens_hsa041440.41833904
123beta-Alanine metabolism_Homo sapiens_hsa004100.40262364
124Endometrial cancer_Homo sapiens_hsa052130.39214315
125Melanogenesis_Homo sapiens_hsa049160.38203308
126Galactose metabolism_Homo sapiens_hsa000520.37348976
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37273521
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36817651
129GnRH signaling pathway_Homo sapiens_hsa049120.34424233
130Tight junction_Homo sapiens_hsa045300.33427102
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.32038191
132Butanoate metabolism_Homo sapiens_hsa006500.31655008
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31619388
134Insulin signaling pathway_Homo sapiens_hsa049100.31599365
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31078734
136Chemical carcinogenesis_Homo sapiens_hsa052040.30162364
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30102231
138Circadian rhythm_Homo sapiens_hsa047100.29921385
139Complement and coagulation cascades_Homo sapiens_hsa046100.29680250
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.28320311
141Cell cycle_Homo sapiens_hsa041100.27894169
142Salivary secretion_Homo sapiens_hsa049700.27491859
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26870565
144Homologous recombination_Homo sapiens_hsa034400.26807107
145Staphylococcus aureus infection_Homo sapiens_hsa051500.26410207
146Estrogen signaling pathway_Homo sapiens_hsa049150.23643975
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.19442056
148Insulin resistance_Homo sapiens_hsa049310.18954444

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »