DCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ketone body metabolic process (GO:1902224)9.90678269
2* tyrosine metabolic process (GO:0006570)9.36154216
3melanocyte differentiation (GO:0030318)8.22884513
4* developmental pigmentation (GO:0048066)7.97970054
5pigment cell differentiation (GO:0050931)7.51592594
6* pigment biosynthetic process (GO:0046148)7.26853930
7melanosome organization (GO:0032438)7.12384606
8pigment granule organization (GO:0048753)6.75957397
9vitamin A metabolic process (GO:0006776)6.64647779
10endosome to pigment granule transport (GO:0043485)5.74565784
11endosome to melanosome transport (GO:0035646)5.74565784
12* pigment metabolic process (GO:0042440)5.60843195
13basement membrane organization (GO:0071711)5.59736234
14regulation of endothelial cell chemotaxis (GO:2001026)5.46889614
15neuroepithelial cell differentiation (GO:0060563)5.28229893
16enteric nervous system development (GO:0048484)5.06621594
17short-chain fatty acid metabolic process (GO:0046459)4.97112185
18myotube differentiation (GO:0014902)4.90104242
19negative regulation of macroautophagy (GO:0016242)4.87901016
20negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.57503842
21mesenchymal-epithelial cell signaling (GO:0060638)4.54892582
22negative regulation of response to reactive oxygen species (GO:1901032)4.18767593
23regulation of hydrogen peroxide-induced cell death (GO:1903205)4.10118694
24* melanin biosynthetic process (GO:0042438)33.4483133
25* melanin metabolic process (GO:0006582)30.0508951
26chondroitin sulfate catabolic process (GO:0030207)3.93345920
27cGMP-mediated signaling (GO:0019934)3.88546405
28COPI coating of Golgi vesicle (GO:0048205)3.88111401
29Golgi transport vesicle coating (GO:0048200)3.88111401
30endothelial cell morphogenesis (GO:0001886)3.77948454
31* phenol-containing compound metabolic process (GO:0018958)3.77900571
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.77610484
33semaphorin-plexin signaling pathway (GO:0071526)3.69129795
34peripheral nervous system development (GO:0007422)3.69040898
35nerve growth factor signaling pathway (GO:0038180)3.61684687
36positive regulation of DNA-dependent DNA replication (GO:2000105)3.59987423
37pore complex assembly (GO:0046931)3.49674293
38melanosome localization (GO:0032400)3.43705811
39long-chain fatty acid biosynthetic process (GO:0042759)3.29532154
40protein retention in ER lumen (GO:0006621)3.28947013
41mitotic G1 DNA damage checkpoint (GO:0031571)3.23988659
42regulation of protein sumoylation (GO:0033233)3.23987643
43pigment granule localization (GO:0051875)3.23426888
44melanosome transport (GO:0032402)3.19577455
45* pigmentation (GO:0043473)3.19417087
46columnar/cuboidal epithelial cell differentiation (GO:0002065)3.18555389
47peptidyl-proline hydroxylation (GO:0019511)3.17002402
48retinal rod cell development (GO:0046548)3.08627938
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08268419
50oligodendrocyte differentiation (GO:0048709)3.05170235
51establishment of melanosome localization (GO:0032401)3.05125998
52sodium ion export (GO:0071436)3.03398831
53regulation of somitogenesis (GO:0014807)3.02581946
54* secondary metabolite biosynthetic process (GO:0044550)27.3518109
55pigment granule transport (GO:0051904)2.97629967
56establishment of pigment granule localization (GO:0051905)2.84761073
57midgut development (GO:0007494)2.84114778
58mitotic G1/S transition checkpoint (GO:0044819)2.82789749
59* aromatic amino acid family metabolic process (GO:0009072)2.82292090
60G1 DNA damage checkpoint (GO:0044783)2.78651363
61epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77997153
62neural crest cell migration (GO:0001755)2.72800186
63desmosome organization (GO:0002934)2.70076768
64retinal metabolic process (GO:0042574)2.70015404
65muscle cell migration (GO:0014812)2.69821812
66body morphogenesis (GO:0010171)2.68172253
67negative regulation of response to nutrient levels (GO:0032108)2.67073795
68negative regulation of response to extracellular stimulus (GO:0032105)2.67073795
69negative regulation of fatty acid biosynthetic process (GO:0045717)2.65999150
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65721690
71layer formation in cerebral cortex (GO:0021819)2.62849647
72barbed-end actin filament capping (GO:0051016)2.58883924
73negative regulation of autophagy (GO:0010507)2.52661257
74fibroblast migration (GO:0010761)2.52551689
75histone H3-K9 demethylation (GO:0033169)2.49884737
76actin filament depolymerization (GO:0030042)2.49741439
77regulation of penile erection (GO:0060405)2.47750102
78negative regulation of transcription by competitive promoter binding (GO:0010944)2.47551124
79regulation of sister chromatid cohesion (GO:0007063)2.45246328
80cellular response to nitric oxide (GO:0071732)2.43833404
81regulation of mitotic spindle organization (GO:0060236)2.43543305
82negative regulation of catenin import into nucleus (GO:0035414)2.43128632
83cellular response to reactive nitrogen species (GO:1902170)2.42984575
84neuron remodeling (GO:0016322)2.42867838
85Rap protein signal transduction (GO:0032486)2.42487987
86cellular potassium ion homeostasis (GO:0030007)2.41338265
87antigen processing and presentation via MHC class Ib (GO:0002475)2.41004728
88bone remodeling (GO:0046849)2.40884408
89dermatan sulfate biosynthetic process (GO:0030208)2.40858388
90protein hydroxylation (GO:0018126)2.39393781
91response to thyroid hormone (GO:0097066)2.38300065
92proline transport (GO:0015824)2.35639893
934-hydroxyproline metabolic process (GO:0019471)2.35531712
94embryonic body morphogenesis (GO:0010172)2.35486544
95negative regulation of organelle assembly (GO:1902116)2.34441020
96regulation of response to reactive oxygen species (GO:1901031)2.33033357
97glucose 6-phosphate metabolic process (GO:0051156)2.32692355
98sialylation (GO:0097503)2.31511422
99negative regulation of oxidative stress-induced cell death (GO:1903202)2.27200862
100regulation of integrin-mediated signaling pathway (GO:2001044)2.25406840
101cellular response to epidermal growth factor stimulus (GO:0071364)2.25022018
102* regulation of neuroblast proliferation (GO:1902692)2.24942086
103regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.24732870
104dosage compensation (GO:0007549)2.22828775
105ectodermal placode formation (GO:0060788)2.22643271
106cranial nerve development (GO:0021545)2.21644565
107dermatan sulfate metabolic process (GO:0030205)2.21437858
108autophagic vacuole fusion (GO:0000046)2.20480624
109cellular response to thyroid hormone stimulus (GO:0097067)2.20315788
110protein complex localization (GO:0031503)2.19833595
111negative regulation of response to oxidative stress (GO:1902883)2.19670256
112negative regulation of cellular response to oxidative stress (GO:1900408)2.19670256
113negative regulation of fatty acid metabolic process (GO:0045922)2.19586128
114nuclear pore complex assembly (GO:0051292)2.17985109
115regulation of mammary gland epithelial cell proliferation (GO:0033599)2.17642363
116L-serine transport (GO:0015825)2.17339026
117muscle cell cellular homeostasis (GO:0046716)2.14866339
118gluconeogenesis (GO:0006094)2.13591364
119* organic hydroxy compound biosynthetic process (GO:1901617)2.13078329
120hyaluronan catabolic process (GO:0030214)2.11506706
121glycoprotein catabolic process (GO:0006516)2.09599449
122response to nerve growth factor (GO:1990089)2.08718313
123cellular response to nerve growth factor stimulus (GO:1990090)2.08718313
124positive regulation of osteoblast proliferation (GO:0033690)2.07513413
125response to nitric oxide (GO:0071731)2.06517177
126regulation of apoptotic cell clearance (GO:2000425)2.05811983
127establishment of nucleus localization (GO:0040023)2.04998672
128behavioral response to ethanol (GO:0048149)2.04368426
129Rac protein signal transduction (GO:0016601)2.02994259
130cellular glucuronidation (GO:0052695)2.02036383
131* phenol-containing compound biosynthetic process (GO:0046189)10.3584073
132* secondary metabolic process (GO:0019748)10.2354743
133retinol metabolic process (GO:0042572)1.92341489
134regulation of short-term neuronal synaptic plasticity (GO:0048172)1.92122176
135osteoclast differentiation (GO:0030316)1.90323329
136cellular response to electrical stimulus (GO:0071257)1.87836983
137positive regulation of glucose transport (GO:0010828)1.87771165
138regulation of early endosome to late endosome transport (GO:2000641)1.82103583
139protein-chromophore linkage (GO:0018298)1.81792019
140uronic acid metabolic process (GO:0006063)1.80346009
141glucuronate metabolic process (GO:0019585)1.80346009
142peptidyl-lysine dimethylation (GO:0018027)1.76970549
143myelin assembly (GO:0032288)1.75265056
144angiogenesis involved in wound healing (GO:0060055)1.73373360
145cellular ketone body metabolic process (GO:0046950)1.72724408
146folic acid-containing compound biosynthetic process (GO:0009396)1.69329169
147positive chemotaxis (GO:0050918)1.67163476
148regulation of centriole replication (GO:0046599)1.66502991
149centrosome duplication (GO:0051298)1.65078357
150positive regulation of Rap GTPase activity (GO:0032854)1.64135012
151specification of organ identity (GO:0010092)1.63584535
152organelle membrane fusion (GO:0090174)1.63035058
153* positive regulation of neuroblast proliferation (GO:0002052)1.62182363
154cerebellar Purkinje cell layer development (GO:0021680)1.61569992
155regulation of oxidative stress-induced cell death (GO:1903201)1.61377199
156glycolytic process (GO:0006096)1.60100600
157iron ion import (GO:0097286)1.56799655
158glycogen biosynthetic process (GO:0005978)1.56303273
159glucan biosynthetic process (GO:0009250)1.56303273
160establishment of mitotic spindle orientation (GO:0000132)1.56129144
161negative regulation of receptor-mediated endocytosis (GO:0048261)1.53699028
162cellular aldehyde metabolic process (GO:0006081)1.52958032
163spinal cord association neuron differentiation (GO:0021527)1.52374633
164regulation of translational fidelity (GO:0006450)1.52232540
165chondroitin sulfate biosynthetic process (GO:0030206)1.50991193
166pentose-phosphate shunt (GO:0006098)1.50617050
167pyruvate metabolic process (GO:0006090)1.46676694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat8.12129537
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.00983161
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.65009652
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.62341754
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.56367958
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.23732779
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09603194
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.05189319
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95194886
10GATA1_22025678_ChIP-Seq_K562_Human2.44267749
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.41131201
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.35408558
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.35103908
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.30862348
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28256183
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07007704
17EGR1_19032775_ChIP-ChIP_M12_Human2.06094836
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01218199
19RBPJ_22232070_ChIP-Seq_NCS_Mouse10.7079632
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99500781
21CLOCK_20551151_ChIP-Seq_293T_Human1.93790737
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90107913
23ZFX_18555785_ChIP-Seq_MESCs_Mouse1.89917316
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87008687
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82422705
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.81915269
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.81565396
28* MITF_21258399_ChIP-Seq_MELANOMA_Human1.78315168
29LXR_22292898_ChIP-Seq_THP-1_Human1.75248562
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69904648
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67416040
32TFEB_21752829_ChIP-Seq_HELA_Human1.66039946
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63600932
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62137191
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.60792189
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60210015
37XRN2_22483619_ChIP-Seq_HELA_Human1.60113237
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59271137
39ZNF263_19887448_ChIP-Seq_K562_Human1.57906995
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54902252
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54565864
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52914075
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52524408
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52319975
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50985937
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49835913
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.49384768
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.47652005
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47619825
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47193452
51KDM2B_26808549_Chip-Seq_K562_Human1.47100907
52RACK7_27058665_Chip-Seq_MCF-7_Human1.46875092
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46503897
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.46380225
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45294645
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43392819
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43293473
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41601855
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40178541
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40114794
61* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39625578
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38946186
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38450554
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37993502
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35750380
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32556089
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32309392
68E2F7_22180533_ChIP-Seq_HELA_Human1.29742284
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.26402993
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25749707
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25032019
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23468707
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23199227
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23137858
75VDR_21846776_ChIP-Seq_THP-1_Human1.22412535
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19787983
77CJUN_26792858_Chip-Seq_BT549_Human1.19660662
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19550699
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17268551
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15373829
81SMC4_20622854_ChIP-Seq_HELA_Human1.14819912
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14774533
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14672295
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14634699
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14336845
86* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13192457
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13073730
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13018207
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12846272
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12826936
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12560167
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11340756
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11200479
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09540320
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09534667
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09534667
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09007267
98MYC_22102868_ChIP-Seq_BL_Human1.08932089
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06665900
100KAP1_27257070_Chip-Seq_ESCs_Mouse1.06254908
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.06212530
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06206373
103FOXA2_19822575_ChIP-Seq_HepG2_Human1.06163536
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04249579
105GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02643513
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02538936
107TP53_16413492_ChIP-PET_HCT116_Human1.02281515
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02237231
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01640799
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01358041
111E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01215588
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.99807872
113DCP1A_22483619_ChIP-Seq_HELA_Human0.99613073
114* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99592841
115* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99592841
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99174513
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99032723
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.98776452
119TTF2_22483619_ChIP-Seq_HELA_Human0.98744401
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98698910
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98233901
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97851248
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97435510
124* BRD4_25478319_ChIP-Seq_HGPS_Human0.96978707
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95798045
126ATF3_27146783_Chip-Seq_COLON_Human0.95794544
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.95791995
128* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95642336
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95432985
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95113438
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.94505381
132NCOR1_26117541_ChIP-Seq_K562_Human0.94324166
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94322536
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92368845
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91116323
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91094126
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90996183
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90760965
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90692871
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.90671297
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90023206
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89559333
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89493457
144AR_21909140_ChIP-Seq_LNCAP_Human0.89154248
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88513423
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87291082
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87178726
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85642093
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.85495029
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84731453
151VDR_24787735_ChIP-Seq_THP-1_Human0.83152819
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81862361
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81782030
154ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81055496
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79896111
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78853609
157RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78786825
158OCT1_27270436_Chip-Seq_PROSTATE_Human0.78077093
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77868846
160* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77369175
161HNF4A_19822575_ChIP-Seq_HepG2_Human0.76904434
162TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76192760
163FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75289694
164TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74693772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.24260216
2MP0005408_hypopigmentation5.77443575
3MP0003136_yellow_coat_color5.29078699
4MP0005257_abnormal_intraocular_pressure4.29607142
5MP0004381_abnormal_hair_follicle4.06739096
6* MP0000371_diluted_coat_color3.79179438
7MP0002095_abnormal_skin_pigmentation3.29559113
8MP0000015_abnormal_ear_pigmentation3.21410509
9MP0002877_abnormal_melanocyte_morpholog3.19175078
10MP0005377_hearing/vestibular/ear_phenot3.09889691
11MP0003878_abnormal_ear_physiology3.09889691
12MP0005075_abnormal_melanosome_morpholog2.55346248
13MP0002102_abnormal_ear_morphology2.48738542
14* MP0001324_abnormal_eye_pigmentation2.45184922
15* MP0002075_abnormal_coat/hair_pigmentati2.19814845
16MP0003011_delayed_dark_adaptation2.10130322
17MP0000569_abnormal_digit_pigmentation2.06402115
18MP0000372_irregular_coat_pigmentation11.2050598
19MP0005174_abnormal_tail_pigmentation1.93727460
20* MP0001186_pigmentation_phenotype1.75656795
21MP0004885_abnormal_endolymph1.70204740
22MP0002938_white_spotting1.69128547
23MP0005248_abnormal_Harderian_gland1.64252452
24MP0002090_abnormal_vision1.33198767
25MP0003705_abnormal_hypodermis_morpholog1.23793866
26MP0002638_abnormal_pupillary_reflex1.14476019
27MP0008260_abnormal_autophagy1.12619931
28MP0005409_darkened_coat_color1.12414783
29MP0005253_abnormal_eye_physiology0.91532479
30* MP0005197_abnormal_uvea_morphology0.90438560
31MP0010234_abnormal_vibrissa_follicle0.78348980
32MP0003453_abnormal_keratinocyte_physiol0.68718088
33MP0008932_abnormal_embryonic_tissue0.66306034
34MP0002089_abnormal_postnatal_growth/wei0.65211500
35MP0005058_abnormal_lysosome_morphology0.64369730
36MP0000733_abnormal_muscle_development0.64256124
37MP0001188_hyperpigmentation0.62075320
38MP0001293_anophthalmia0.61539656
39MP0005551_abnormal_eye_electrophysiolog0.60593879
40MP0008569_lethality_at_weaning0.59844010
41MP0010094_abnormal_chromosome_stability0.54457469
42MP0009379_abnormal_foot_pigmentation0.54298804
43MP0006054_spinal_hemorrhage0.53777246
44* MP0000367_abnormal_coat/_hair0.53283812
45MP0005391_vision/eye_phenotype0.52730831
46MP0002092_abnormal_eye_morphology0.51629001
47MP0002060_abnormal_skin_morphology0.47720913
48MP0008438_abnormal_cutaneous_collagen0.45513715
49MP0000377_abnormal_hair_follicle0.44559711
50MP0001851_eye_inflammation0.42860804
51MP0000762_abnormal_tongue_morphology0.42348818
52MP0009840_abnormal_foam_cell0.42068438
53MP0003123_paternal_imprinting0.41122319
54MP0006138_congestive_heart_failure0.40985359
55MP0009697_abnormal_copulation0.40979101
56MP0002139_abnormal_hepatobiliary_system0.40483190
57MP0003634_abnormal_glial_cell0.40068739
58MP0001485_abnormal_pinna_reflex0.38409479
59MP0003077_abnormal_cell_cycle0.37996799
60MP0002177_abnormal_outer_ear0.37079708
61MP0005023_abnormal_wound_healing0.35274870
62MP0005623_abnormal_meninges_morphology0.35081019
63MP0001849_ear_inflammation0.33696002
64MP0005670_abnormal_white_adipose0.32744662
65MP0010307_abnormal_tumor_latency0.32108630
66MP0003566_abnormal_cell_adhesion0.31031409
67MP0002751_abnormal_autonomic_nervous0.30556804
68MP0003191_abnormal_cellular_cholesterol0.28731142
69MP0004859_abnormal_synaptic_plasticity0.27756237
70MP0010030_abnormal_orbit_morphology0.27515438
71MP0004084_abnormal_cardiac_muscle0.26332242
72MP0003943_abnormal_hepatobiliary_system0.26151313
73* MP0005193_abnormal_anterior_eye0.26129442
74MP0000639_abnormal_adrenal_gland0.24889233
75MP0003950_abnormal_plasma_membrane0.23241268
76MP0003091_abnormal_cell_migration0.22353158
77MP0008770_decreased_survivor_rate0.22314783
78MP0008007_abnormal_cellular_replicative0.20504435
79MP0002396_abnormal_hematopoietic_system0.20213610
80MP0001270_distended_abdomen0.20090094
81MP0000350_abnormal_cell_proliferation0.19936149
82MP0000358_abnormal_cell_content/0.19513267
83MP0004233_abnormal_muscle_weight0.19003463
84MP0005423_abnormal_somatic_nervous0.18579095
85MP0005187_abnormal_penis_morphology0.18433669
86MP0005384_cellular_phenotype0.18060227
87MP0003172_abnormal_lysosome_physiology0.17927646
88MP0001958_emphysema0.17334721
89MP0004147_increased_porphyrin_level0.17166554
90MP0005621_abnormal_cell_physiology0.16818159
91MP0003567_abnormal_fetal_cardiomyocyte0.16661123
92MP0001915_intracranial_hemorrhage0.16394307
93MP0002998_abnormal_bone_remodeling0.16105610
94MP0005386_behavior/neurological_phenoty0.16079975
95MP0004924_abnormal_behavior0.16079975
96MP0009046_muscle_twitch0.15794677
97MP0001348_abnormal_lacrimal_gland0.15607302
98MP0004272_abnormal_basement_membrane0.14473564
99MP0000462_abnormal_digestive_system0.14154136
100MP0004019_abnormal_vitamin_homeostasis0.13817486
101MP0000749_muscle_degeneration0.13814637
102MP0004957_abnormal_blastocyst_morpholog0.13439260
103MP0003385_abnormal_body_wall0.13120702
104MP0004197_abnormal_fetal_growth/weight/0.11781258
105MP0003690_abnormal_glial_cell0.11097296
106MP0000534_abnormal_ureter_morphology0.11074764
107MP0002697_abnormal_eye_size0.11020728
108MP0001502_abnormal_circadian_rhythm0.10869303
109MP0005195_abnormal_posterior_eye0.10831102
110MP0010352_gastrointestinal_tract_polyps0.10609851
111MP0002796_impaired_skin_barrier0.10378351
112MP0000432_abnormal_head_morphology0.08860706
113MP0010329_abnormal_lipoprotein_level0.08762850
114MP0003329_amyloid_beta_deposits0.08666630
115MP0000647_abnormal_sebaceous_gland0.08459758
116MP0001299_abnormal_eye_distance/0.07637767
117MP0002229_neurodegeneration0.07543484
118MP0003938_abnormal_ear_development0.07275313
119MP0005508_abnormal_skeleton_morphology0.07223460
120MP0005275_abnormal_skin_tensile0.06205478
121MP0000747_muscle_weakness0.05699543
122MP0000920_abnormal_myelination0.04767298
123MP0004808_abnormal_hematopoietic_stem0.04236745
124MP0005503_abnormal_tendon_morphology0.03131432
125MP0000955_abnormal_spinal_cord0.02734085
126MP0005164_abnormal_response_to0.02678962
127MP0003937_abnormal_limbs/digits/tail_de0.02500597
128MP0005360_urolithiasis0.02262625
129MP0000609_abnormal_liver_physiology0.02201610
130MP0009703_decreased_birth_body0.02170448
131MP0004036_abnormal_muscle_relaxation0.02116470
132MP0005083_abnormal_biliary_tract0.01957611
133MP0000537_abnormal_urethra_morphology0.01829214
134MP0003632_abnormal_nervous_system0.01792139
135MP0001963_abnormal_hearing_physiology0.01771404
136MP0002269_muscular_atrophy0.01415577
137MP0003111_abnormal_nucleus_morphology0.01086907
138MP0009384_cardiac_valve_regurgitation0.01050045

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)9.40273949
2Hypopigmentation of the fundus (HP:0007894)8.57145357
3Iris hypopigmentation (HP:0007730)8.24470521
4Generalized hypopigmentation (HP:0007513)6.64208585
5White forelock (HP:0002211)6.18112893
6Congenital sensorineural hearing impairment (HP:0008527)5.81370231
7Subacute progressive viral hepatitis (HP:0006572)5.57659027
8Patchy hypopigmentation of hair (HP:0011365)5.51677933
9Hypoplasia of the iris (HP:0007676)4.90814366
10Freckling (HP:0001480)4.56378305
11Peripheral hypomyelination (HP:0007182)4.44604678
12Generalized hypopigmentation of hair (HP:0011358)4.39986554
13Heterochromia iridis (HP:0001100)4.35995280
14Cutaneous melanoma (HP:0012056)4.26818867
15Bilateral sensorineural hearing impairment (HP:0008619)3.70225993
16Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.64983068
17Premature graying of hair (HP:0002216)3.56772557
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.21511627
19Asymmetric septal hypertrophy (HP:0001670)3.20149194
20Viral hepatitis (HP:0006562)3.11100696
21Micronodular cirrhosis (HP:0001413)3.01261587
22Cerebral hypomyelination (HP:0006808)2.98531472
23Albinism (HP:0001022)2.97048139
24Protrusio acetabuli (HP:0003179)2.93995386
25Alacrima (HP:0000522)2.93555495
26Morphological abnormality of the inner ear (HP:0011390)2.92348668
27J-shaped sella turcica (HP:0002680)2.89943977
28Vertebral compression fractures (HP:0002953)2.76878762
29Hepatocellular carcinoma (HP:0001402)2.72605448
30Urinary glycosaminoglycan excretion (HP:0003541)2.59860780
31Mucopolysacchariduria (HP:0008155)2.59860780
32Cerebral aneurysm (HP:0004944)2.44059782
33Abnormal autonomic nervous system physiology (HP:0012332)2.36299704
34Melanoma (HP:0002861)2.36267957
35Abnormality of polysaccharide metabolism (HP:0011012)2.35306789
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35306789
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35306789
38Dysostosis multiplex (HP:0000943)2.18366944
39Abnormality of vision evoked potentials (HP:0000649)2.17939098
40Decreased lacrimation (HP:0000633)2.12499010
41Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08335451
42Absent epiphyses (HP:0010577)2.08335451
43Abnormality of liposaccharide metabolism (HP:0010968)2.04936162
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.04936162
45Abnormality of glycolipid metabolism (HP:0010969)2.04936162
46Abnormality of the salivary glands (HP:0010286)2.01774973
47Cholecystitis (HP:0001082)2.00409095
48Abnormal gallbladder physiology (HP:0012438)2.00409095
49Aplasia/Hypoplasia of the macula (HP:0008059)12.0833208
50Aplasia/Hypoplasia affecting the retina (HP:0008061)11.3236935
51Hypoplasia of the fovea (HP:0007750)11.2551263
52Aplasia/Hypoplasia of the fovea (HP:0008060)11.2551263
53Blue irides (HP:0000635)11.1742070
54Abnormality of the fovea (HP:0000493)10.0341102
55Spastic diplegia (HP:0001264)1.98303775
56Termporal pattern (HP:0011008)1.95521523
57Insidious onset (HP:0003587)1.95521523
58Scapular winging (HP:0003691)1.89929943
59Abnormal auditory evoked potentials (HP:0006958)1.89426178
60Upper limb muscle weakness (HP:0003484)1.89094071
61Decreased central vision (HP:0007663)1.87433680
62Ulnar claw (HP:0001178)1.87171714
63Synophrys (HP:0000664)1.81887603
64Action tremor (HP:0002345)1.79596781
65Attenuation of retinal blood vessels (HP:0007843)1.77725501
66Rhabdomyosarcoma (HP:0002859)1.69003669
67Cerebral inclusion bodies (HP:0100314)1.68177407
68Neoplasm of the oral cavity (HP:0100649)1.67873416
69Renal cell carcinoma (HP:0005584)1.66854720
70Postural tremor (HP:0002174)1.62190438
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62114664
72Melanocytic nevus (HP:0000995)1.61208023
73Deformed sella turcica (HP:0002681)1.60424187
74Impaired proprioception (HP:0010831)1.60162339
75Neurofibrillary tangles (HP:0002185)1.58210121
76Exercise-induced muscle cramps (HP:0003710)1.57615013
77Segmental peripheral demyelination/remyelination (HP:0003481)1.56787175
78Underdeveloped nasal alae (HP:0000430)1.56212749
79Shallow orbits (HP:0000586)1.55957027
80Akinesia (HP:0002304)1.53879487
81Hypermelanotic macule (HP:0001034)1.48668159
82Conjunctival hamartoma (HP:0100780)1.45902879
83Ovoid vertebral bodies (HP:0003300)1.45636276
84Photophobia (HP:0000613)1.43755430
85Large for gestational age (HP:0001520)1.42666754
86Lip pit (HP:0100267)1.40225812
87Decreased motor nerve conduction velocity (HP:0003431)1.40027575
88CNS hypomyelination (HP:0003429)1.38943925
89Nuclear cataract (HP:0100018)1.38329938
90Loss of speech (HP:0002371)1.37597300
91Abnormality of glycolysis (HP:0004366)1.37363158
92Hepatitis (HP:0012115)1.37176435
93Hyperacusis (HP:0010780)1.36481833
94Supernumerary nipples (HP:0002558)1.35899886
95Tented upper lip vermilion (HP:0010804)1.35834791
96Hamartoma of the eye (HP:0010568)1.35210894
97Peripheral demyelination (HP:0011096)1.35193452
98Coarse hair (HP:0002208)1.34905724
99Foot dorsiflexor weakness (HP:0009027)1.34266608
100Narrow nasal bridge (HP:0000446)1.31758032
101Increased corneal curvature (HP:0100692)1.31573119
102Keratoconus (HP:0000563)1.31573119
103Germ cell neoplasia (HP:0100728)1.29730217
104Reticulocytosis (HP:0001923)1.28650926
105Morphological abnormality of the middle ear (HP:0008609)1.28552927
106Elbow flexion contracture (HP:0002987)1.27984472
107Long toe (HP:0010511)1.26957718
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.25589959
109Osteolytic defects of the hand bones (HP:0009699)1.25589959
110Supernumerary ribs (HP:0005815)1.25569408
111Hand muscle atrophy (HP:0009130)1.25246185
112Wormian bones (HP:0002645)1.24078866
113Deep venous thrombosis (HP:0002625)1.23459234
114Leiomyosarcoma (HP:0100243)1.20443183
115Uterine leiomyosarcoma (HP:0002891)1.20443183
116Joint stiffness (HP:0001387)1.20383998
117Cholelithiasis (HP:0001081)1.20255371
118Bell-shaped thorax (HP:0001591)1.19645046
119Deep philtrum (HP:0002002)1.19309179
120Hypopigmented skin patches (HP:0001053)1.18820569
121Abnormality of the anterior chamber (HP:0000593)1.18292374
122Nasal speech (HP:0001611)1.18167879
123Biconcave vertebral bodies (HP:0004586)1.17712008
124Increased cerebral lipofuscin (HP:0011813)1.17132986
125Ulnar deviation of finger (HP:0009465)1.16926249
126Supranuclear gaze palsy (HP:0000605)1.16263958
127Abnormality of the foot musculature (HP:0001436)1.16206632
128Neoplasm of striated muscle (HP:0009728)1.14970623
129Myelomeningocele (HP:0002475)1.14956691
130Skin nodule (HP:0200036)1.14065730
131Premature rupture of membranes (HP:0001788)1.14007301
132Hypermetropia (HP:0000540)1.13610580
133Spastic paraplegia (HP:0001258)1.13262017
134Aortic aneurysm (HP:0004942)1.11104306
135Neoplasm of the liver (HP:0002896)1.08631456
136Asymmetry of the thorax (HP:0001555)1.06411922
137Distal upper limb amyotrophy (HP:0007149)1.06212202
138Upper limb amyotrophy (HP:0009129)1.06212202
139Paraparesis (HP:0002385)1.06009889
140Supernumerary bones of the axial skeleton (HP:0009144)1.04262787
141Tracheomalacia (HP:0002779)1.03814014
142Synostosis of carpal bones (HP:0005048)1.03725318
143Overlapping toe (HP:0001845)1.03193939
144Spastic paraparesis (HP:0002313)1.01434476
145Bladder diverticulum (HP:0000015)1.00283968
146Paraplegia (HP:0010550)1.00210158
147Vascular tortuosity (HP:0004948)0.98172543
148Xanthomatosis (HP:0000991)0.96186624
149Parkinsonism with favorable response to dopaminergic medication (HP:0002548)0.94698486
150Atelectasis (HP:0100750)0.92825350
151Abnormality of the shoulder girdle musculature (HP:0001435)0.92598678
152Carpal synostosis (HP:0009702)0.91168642
153Visceral angiomatosis (HP:0100761)0.91036357
154Exostoses (HP:0100777)0.90513372
155Ulnar deviation of the hand or of fingers of the hand (HP:0001193)0.90278118
156Hemangiomatosis (HP:0007461)0.88005120
157Cutaneous finger syndactyly (HP:0010554)0.87812020
158Distal sensory impairment (HP:0002936)0.87596321
159Macroorchidism (HP:0000053)0.87494772
160Spontaneous hematomas (HP:0007420)0.85506431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.58822099
2PKN24.16454002
3MARK33.90358335
4BMX3.85647053
5PDK23.33945447
6WEE13.09734924
7ICK3.09579214
8TRIB32.96956866
9PRKD32.49044421
10EPHA32.31412781
11MAP3K32.09275621
12MST1R12.7279971
13MAPKAPK31.75564046
14SCYL21.61987364
15DDR21.42396575
16CDK31.39057541
17EIF2AK11.20998214
18CDK121.19715252
19LATS11.16780839
20FLT31.10986059
21PTK61.06152014
22NME21.05513378
23CDK181.02768365
24CDK151.02516354
25NEK61.02402762
26CDK11A1.02156237
27SMG10.96508312
28LRRK20.93084444
29BRSK10.91009322
30MAPKAPK50.89438699
31TTN0.88489932
32NEK10.87726413
33CDK140.85104573
34MATK0.81424090
35GSK3A0.80904149
36CAMKK10.79228804
37CSNK1G10.77911732
38CSNK1A1L0.77296302
39MAP3K60.75964397
40CSNK1G30.74163291
41NTRK20.73846674
42PDPK10.71527649
43TTK0.69271805
44KSR20.66935988
45NEK20.65584770
46RET0.65276116
47MTOR0.63867788
48CLK10.60410045
49PAK40.60250603
50SIK20.58734274
51CSNK1G20.57600968
52UHMK10.55674000
53KSR10.54538605
54EEF2K0.54314477
55PDGFRA0.53400495
56SIK30.53051384
57BUB10.51951013
58FER0.49875119
59CAMKK20.47774108
60NTRK30.46403609
61ILK0.45102791
62PRKD20.44339940
63FGFR40.43710095
64TSSK60.43574010
65MAPK100.42924110
66BRD40.41656786
67PAK60.41600868
68TBK10.41496104
69AKT20.37947360
70RPS6KB20.37624028
71MAP3K130.36541665
72CDK60.36147936
73PRKG20.35186510
74MAPK70.35094601
75RIPK10.34258134
76FRK0.34209668
77BRAF0.33112273
78MAP3K90.32501254
79KIT0.31437729
80MAP2K10.31138709
81ERBB40.30299553
82PAK10.29365000
83INSR0.28606129
84DYRK1B0.28571557
85AKT10.28453433
86FGFR20.28291846
87NTRK10.27005674
88CAMK1D0.26792620
89ATR0.26595113
90CDK70.24459585
91PRKCZ0.23853010
92PRKCE0.23783735
93TYRO30.23424664
94PTK20.22405445
95MAP3K110.22091367
96EPHB10.21150051
97MAP3K80.20837039
98DMPK0.20206562
99FGR0.19959587
100PDGFRB0.18884816
101FGFR30.18167321
102PAK30.15960712
103LMTK20.15757248
104MAP3K20.15661321
105PAK20.15247876
106FGFR10.15004984
107RAF10.14645478
108STK30.14058787
109SIK10.13509219
110SGK30.13367305
111SRC0.12761495
112CSNK1D0.12199605
113STK40.12052227
114ABL10.11836792
115ALK0.11659210
116IGF1R0.11608982
117WNK40.11536603
118RPS6KA10.11029927
119BRSK20.10275853
120LATS20.09250673
121NEK90.09215556
122SGK20.08873735
123MAPK30.08806414
124ARAF0.08684299
125OBSCN0.08124501
126TRPM70.07806595
127PDK10.07589189
128TGFBR20.07329759
129MOS0.07159596
130PRKAA20.07076079
131CAMK1G0.06772045
132MAPK120.06098820
133PRKD10.05742818
134ERBB20.05427545
135PLK20.04989297
136PRKACB0.04857771
137MAPK110.04818039
138MAP3K10.04653520
139CHEK20.04264157
140MAP2K60.04139058
141PRKCQ0.03764926
142PRKCH0.03191613

Predicted pathways (KEGG)

RankGene SetZ-score
1* Tyrosine metabolism_Homo sapiens_hsa003507.89921769
2Glycosaminoglycan degradation_Homo sapiens_hsa005315.39228490
3Other glycan degradation_Homo sapiens_hsa005112.97478041
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.92584506
5* Melanogenesis_Homo sapiens_hsa049162.92012691
6Central carbon metabolism in cancer_Homo sapiens_hsa052302.65397205
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41346175
8Thyroid cancer_Homo sapiens_hsa052162.39502235
9Galactose metabolism_Homo sapiens_hsa000522.17724059
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.06474079
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.02795201
12Renal cell carcinoma_Homo sapiens_hsa052112.00738875
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.98702541
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85297387
15Melanoma_Homo sapiens_hsa052181.83849646
16Cell cycle_Homo sapiens_hsa041101.62539408
17Biosynthesis of amino acids_Homo sapiens_hsa012301.59916247
18Retinol metabolism_Homo sapiens_hsa008301.59483324
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.56784744
20Starch and sucrose metabolism_Homo sapiens_hsa005001.52487383
21Synaptic vesicle cycle_Homo sapiens_hsa047211.42764336
22Fructose and mannose metabolism_Homo sapiens_hsa000511.35005993
23Adherens junction_Homo sapiens_hsa045201.32747269
24Oocyte meiosis_Homo sapiens_hsa041141.29941338
25DNA replication_Homo sapiens_hsa030301.25565764
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21647255
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20874717
28Lysosome_Homo sapiens_hsa041421.20765141
29Carbon metabolism_Homo sapiens_hsa012001.20504198
30Phenylalanine metabolism_Homo sapiens_hsa003601.15635498
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14316621
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11791900
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10867701
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02072643
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01873798
36Pentose phosphate pathway_Homo sapiens_hsa000301.01305708
37Vibrio cholerae infection_Homo sapiens_hsa051101.01290348
38One carbon pool by folate_Homo sapiens_hsa006701.00262413
39Glioma_Homo sapiens_hsa052140.99711628
40HIF-1 signaling pathway_Homo sapiens_hsa040660.98845925
41Acute myeloid leukemia_Homo sapiens_hsa052210.96636179
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96128838
43Fat digestion and absorption_Homo sapiens_hsa049750.95922219
44ECM-receptor interaction_Homo sapiens_hsa045120.95407523
45Prion diseases_Homo sapiens_hsa050200.94330257
46N-Glycan biosynthesis_Homo sapiens_hsa005100.94193586
47Bile secretion_Homo sapiens_hsa049760.93827371
48Butanoate metabolism_Homo sapiens_hsa006500.92384241
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91621799
50Systemic lupus erythematosus_Homo sapiens_hsa053220.90679008
51Linoleic acid metabolism_Homo sapiens_hsa005910.88750922
52Proteoglycans in cancer_Homo sapiens_hsa052050.88708912
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87515531
54Malaria_Homo sapiens_hsa051440.87150714
55Non-homologous end-joining_Homo sapiens_hsa034500.85671101
56Focal adhesion_Homo sapiens_hsa045100.85274164
57Collecting duct acid secretion_Homo sapiens_hsa049660.80600421
58mTOR signaling pathway_Homo sapiens_hsa041500.77982002
59Small cell lung cancer_Homo sapiens_hsa052220.77391675
60Chronic myeloid leukemia_Homo sapiens_hsa052200.77328160
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76938614
62Mismatch repair_Homo sapiens_hsa034300.76872014
63Vitamin B6 metabolism_Homo sapiens_hsa007500.73950092
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73710168
65Axon guidance_Homo sapiens_hsa043600.72522774
66Arginine biosynthesis_Homo sapiens_hsa002200.71653122
67MicroRNAs in cancer_Homo sapiens_hsa052060.71007746
68Ribosome_Homo sapiens_hsa030100.70270389
69mRNA surveillance pathway_Homo sapiens_hsa030150.69874889
70Sphingolipid metabolism_Homo sapiens_hsa006000.67814718
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67442880
72Nitrogen metabolism_Homo sapiens_hsa009100.66525553
73Steroid biosynthesis_Homo sapiens_hsa001000.63992021
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63706107
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63497310
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.63073596
77Estrogen signaling pathway_Homo sapiens_hsa049150.62940567
78Base excision repair_Homo sapiens_hsa034100.62862013
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.62697781
80Bladder cancer_Homo sapiens_hsa052190.62533738
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61702136
82Fatty acid metabolism_Homo sapiens_hsa012120.58988074
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58819906
84Prostate cancer_Homo sapiens_hsa052150.56762057
85Endocytosis_Homo sapiens_hsa041440.55166921
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.54422300
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53966349
88VEGF signaling pathway_Homo sapiens_hsa043700.53677635
89Hepatitis B_Homo sapiens_hsa051610.53411908
90Alcoholism_Homo sapiens_hsa050340.52827042
91Glucagon signaling pathway_Homo sapiens_hsa049220.52629436
92Fatty acid degradation_Homo sapiens_hsa000710.52032875
93Endometrial cancer_Homo sapiens_hsa052130.51362585
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.51174621
95Vitamin digestion and absorption_Homo sapiens_hsa049770.50893294
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50879909
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50604626
98p53 signaling pathway_Homo sapiens_hsa041150.50287871
99Insulin signaling pathway_Homo sapiens_hsa049100.50265952
100Sulfur metabolism_Homo sapiens_hsa009200.49726388
101Long-term potentiation_Homo sapiens_hsa047200.48293878
102RNA transport_Homo sapiens_hsa030130.47789755
103GnRH signaling pathway_Homo sapiens_hsa049120.47698924
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46081107
105Pathways in cancer_Homo sapiens_hsa052000.45942798
106Prolactin signaling pathway_Homo sapiens_hsa049170.45495026
107Thyroid hormone synthesis_Homo sapiens_hsa049180.44491883
108Tight junction_Homo sapiens_hsa045300.44354810
109Propanoate metabolism_Homo sapiens_hsa006400.44205628
110ErbB signaling pathway_Homo sapiens_hsa040120.43145112
111Viral carcinogenesis_Homo sapiens_hsa052030.42384673
112Pyruvate metabolism_Homo sapiens_hsa006200.41757974
113Proteasome_Homo sapiens_hsa030500.39965740
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39575490
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39377519
116Insulin resistance_Homo sapiens_hsa049310.39365226
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39186102
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38744412
119Chemical carcinogenesis_Homo sapiens_hsa052040.38554134
120Sulfur relay system_Homo sapiens_hsa041220.37514943
121Ras signaling pathway_Homo sapiens_hsa040140.37459749
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36494849
123Spliceosome_Homo sapiens_hsa030400.36163015
124Selenocompound metabolism_Homo sapiens_hsa004500.33395205
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.33075102
126Rap1 signaling pathway_Homo sapiens_hsa040150.30620543
127Osteoclast differentiation_Homo sapiens_hsa043800.30544562
128Ether lipid metabolism_Homo sapiens_hsa005650.30426126
129Inositol phosphate metabolism_Homo sapiens_hsa005620.30379995
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28940552
131Fatty acid elongation_Homo sapiens_hsa000620.28611490
132Non-small cell lung cancer_Homo sapiens_hsa052230.27693337
133AMPK signaling pathway_Homo sapiens_hsa041520.24481002
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.21896699
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21499906
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19500083
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18751205
138Complement and coagulation cascades_Homo sapiens_hsa046100.18425038
139Lysine degradation_Homo sapiens_hsa003100.17552389
140Colorectal cancer_Homo sapiens_hsa052100.16975193

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