DCTD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.32528040
2DNA strand elongation involved in DNA replication (GO:0006271)4.84565898
3ribosomal small subunit assembly (GO:0000028)4.83440942
4COPI coating of Golgi vesicle (GO:0048205)4.70785624
5Golgi transport vesicle coating (GO:0048200)4.70785624
6telomere maintenance via semi-conservative replication (GO:0032201)4.69334045
7DNA replication initiation (GO:0006270)4.69285847
8protein maturation by protein folding (GO:0022417)4.65694393
9DNA strand elongation (GO:0022616)4.61509971
10maturation of SSU-rRNA (GO:0030490)4.60353599
11nucleobase biosynthetic process (GO:0046112)4.57302826
12purine nucleobase biosynthetic process (GO:0009113)4.43870772
13pinocytosis (GO:0006907)4.31975269
14DNA replication checkpoint (GO:0000076)4.30984586
15formation of translation preinitiation complex (GO:0001731)4.30021813
16telomere maintenance via recombination (GO:0000722)4.15436954
17DNA unwinding involved in DNA replication (GO:0006268)4.13770188
18IMP biosynthetic process (GO:0006188)4.10229124
19ribosome assembly (GO:0042255)4.08639907
20ribosome biogenesis (GO:0042254)4.06336465
21mitotic metaphase plate congression (GO:0007080)4.03452866
22CENP-A containing nucleosome assembly (GO:0034080)3.95024514
23viral transcription (GO:0019083)3.93970620
24translational termination (GO:0006415)3.89816009
25ribonucleoprotein complex biogenesis (GO:0022613)3.89330635
26mitotic recombination (GO:0006312)3.85897073
27pseudouridine synthesis (GO:0001522)3.85492624
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83535945
29protein localization to kinetochore (GO:0034501)3.83491610
30chromatin remodeling at centromere (GO:0031055)3.83285549
31ribosomal large subunit biogenesis (GO:0042273)3.83160581
32telomere maintenance via telomere lengthening (GO:0010833)3.78040123
33protein retention in ER lumen (GO:0006621)3.76318957
34ribosomal small subunit biogenesis (GO:0042274)3.70792512
35kinetochore organization (GO:0051383)3.70730371
36rRNA processing (GO:0006364)3.66061692
37translational elongation (GO:0006414)3.62981143
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62637515
39kinetochore assembly (GO:0051382)3.62196637
40IMP metabolic process (GO:0046040)3.59814079
41proteasome assembly (GO:0043248)3.59537620
42spliceosomal snRNP assembly (GO:0000387)3.59198141
43DNA replication-independent nucleosome organization (GO:0034724)3.58964088
44DNA replication-independent nucleosome assembly (GO:0006336)3.58964088
45translational initiation (GO:0006413)3.58019872
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.57072801
47type B pancreatic cell proliferation (GO:0044342)3.56156257
48metaphase plate congression (GO:0051310)3.52733008
49rRNA metabolic process (GO:0016072)3.52614250
50DNA replication-dependent nucleosome assembly (GO:0006335)3.51653437
51DNA replication-dependent nucleosome organization (GO:0034723)3.51653437
52mitotic nuclear envelope disassembly (GO:0007077)3.49319315
53rRNA modification (GO:0000154)3.36089394
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.35039033
55maturation of 5.8S rRNA (GO:0000460)3.31721851
56skin morphogenesis (GO:0043589)3.31364855
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31282783
58regulation of double-strand break repair via homologous recombination (GO:0010569)3.27075347
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26501023
60viral mRNA export from host cell nucleus (GO:0046784)3.25361319
61protein localization to chromosome, centromeric region (GO:0071459)3.24348876
62histone exchange (GO:0043486)3.20961748
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.20820221
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.20587304
65peptidyl-proline hydroxylation (GO:0019511)3.20036252
66transcription-coupled nucleotide-excision repair (GO:0006283)3.19601324
67nuclear envelope disassembly (GO:0051081)3.18450412
68membrane disassembly (GO:0030397)3.18450412
69cotranslational protein targeting to membrane (GO:0006613)3.16699627
70regulation of spindle organization (GO:0090224)3.16271661
71protein targeting to ER (GO:0045047)3.14583947
72attachment of spindle microtubules to kinetochore (GO:0008608)3.14036107
73folic acid-containing compound biosynthetic process (GO:0009396)3.13667386
74termination of RNA polymerase III transcription (GO:0006386)3.11672181
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.11672181
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08111295
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07286836
78negative regulation of chromosome segregation (GO:0051985)3.03534867
79establishment of chromosome localization (GO:0051303)3.03182543
80cellular protein complex disassembly (GO:0043624)3.03122491
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02255039
82cell cycle G1/S phase transition (GO:0044843)3.01642318
83G1/S transition of mitotic cell cycle (GO:0000082)3.01642318
84cellular component biogenesis (GO:0044085)3.01039129
85viral life cycle (GO:0019058)3.00974095
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00874770
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.00874770
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00307632
89fibril organization (GO:0097435)2.99778063
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.98961713
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98961713
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98961713
93negative regulation of sister chromatid segregation (GO:0033046)2.98961713
94protein localization to endoplasmic reticulum (GO:0070972)2.98144007
95pentose-phosphate shunt (GO:0006098)2.98020867
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97845316
97replication fork processing (GO:0031297)2.96703031
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95904849
99membrane raft organization (GO:0031579)2.95739777
100folic acid metabolic process (GO:0046655)2.95012020
101nucleobase-containing small molecule interconversion (GO:0015949)2.94812939
102spindle assembly checkpoint (GO:0071173)2.93062425
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93059566
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92728505
105mitotic spindle assembly checkpoint (GO:0007094)2.92434134
106translation (GO:0006412)2.92217506
107telomere maintenance (GO:0000723)2.91240190
108telomere organization (GO:0032200)2.91157534
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91092422
110spindle checkpoint (GO:0031577)2.90280982
111establishment of integrated proviral latency (GO:0075713)2.89833990
112meiotic chromosome segregation (GO:0045132)2.89541298
113nuclear-transcribed mRNA catabolic process (GO:0000956)2.87569458
114ncRNA processing (GO:0034470)2.87132375
115endodermal cell differentiation (GO:0035987)2.86515612
116negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.85680794
117UV protection (GO:0009650)2.85185926
118protein hydroxylation (GO:0018126)2.84366449
119extracellular fibril organization (GO:0043206)2.81824053
120barbed-end actin filament capping (GO:0051016)2.80522760
121hyaluronan catabolic process (GO:0030214)2.80056675
122regulation of plasminogen activation (GO:0010755)2.78480630
123NADPH regeneration (GO:0006740)2.76498651
124proline biosynthetic process (GO:0006561)2.74956986
125regulation of metalloenzyme activity (GO:0048552)2.74944683
126nucleotide-sugar biosynthetic process (GO:0009226)2.73218695
127protein localization to endosome (GO:0036010)2.69940817
128cell adhesion mediated by integrin (GO:0033627)2.64406949
129GDP-mannose metabolic process (GO:0019673)2.64396351
130regulation of translational termination (GO:0006449)2.60231636
131AMP metabolic process (GO:0046033)2.58835545
132muscle cell migration (GO:0014812)2.58100576
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55742487
134endoplasmic reticulum unfolded protein response (GO:0030968)2.54159708
135positive regulation of nuclease activity (GO:0032075)2.52327758
136mitotic nuclear envelope reassembly (GO:0007084)2.52311947
137nuclear envelope reassembly (GO:0031468)2.52311947
138COPII vesicle coating (GO:0048208)2.50577567
139stress fiber assembly (GO:0043149)2.50195279
140hemidesmosome assembly (GO:0031581)2.49690671
141glucose catabolic process (GO:0006007)2.47475507
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47313394
143collagen fibril organization (GO:0030199)2.46480450
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39364028
145negative regulation of smooth muscle cell migration (GO:0014912)2.39110351
146apoptotic cell clearance (GO:0043277)2.38333791
147establishment of viral latency (GO:0019043)2.38127796
148deoxyribose phosphate biosynthetic process (GO:0046385)2.36520892
1492-deoxyribonucleotide biosynthetic process (GO:0009265)2.36520892
150cellular response to unfolded protein (GO:0034620)2.36191395
151regulation of mitochondrial translation (GO:0070129)2.33970761
152negative regulation of ligase activity (GO:0051352)2.32608582
153negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.32608582
154positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.31839397
155positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.29622629
156deoxyribonucleotide biosynthetic process (GO:0009263)2.26361287
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.25484192
158regulation of nuclease activity (GO:0032069)2.25319412
159protein heterotrimerization (GO:0070208)2.23949985
160ER-nucleus signaling pathway (GO:0006984)2.22929161
161regulation of mammary gland epithelial cell proliferation (GO:0033599)2.22401345
162cell-substrate junction assembly (GO:0007044)2.22137147
163hypotonic response (GO:0006971)2.22017429
164cellular response to topologically incorrect protein (GO:0035967)2.14270276
165vesicle coating (GO:0006901)2.12337535
166protein N-linked glycosylation via asparagine (GO:0018279)2.11263970
167pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.11136816
168protein targeting to membrane (GO:0006612)2.10969025
169pteridine-containing compound biosynthetic process (GO:0042559)2.10217786
170regulation of early endosome to late endosome transport (GO:2000641)2.09757998
171peptidyl-asparagine modification (GO:0018196)2.08708704
172cell migration involved in heart development (GO:0060973)2.08445565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22838385
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.72744128
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82190491
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53825578
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.30626692
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25828629
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16095029
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11925131
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.09077524
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.08723229
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08663380
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03543239
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01304060
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.98577079
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.95912601
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69416537
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58934554
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53107351
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43663953
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37318949
21XRN2_22483619_ChIP-Seq_HELA_Human2.37216767
22VDR_23849224_ChIP-Seq_CD4+_Human2.30227028
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26386738
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16308652
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15483780
26AR_21909140_ChIP-Seq_LNCAP_Human2.11949093
27FOXP3_21729870_ChIP-Seq_TREG_Human2.05003078
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.02194469
29GABP_19822575_ChIP-Seq_HepG2_Human2.02123774
30DCP1A_22483619_ChIP-Seq_HELA_Human2.00803522
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.97057609
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97027320
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95190318
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93793621
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92353292
36TTF2_22483619_ChIP-Seq_HELA_Human1.92349976
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91067000
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89726682
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88758792
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88472267
41ZNF263_19887448_ChIP-Seq_K562_Human1.84894349
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83995117
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82799186
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81941961
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79930624
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79896443
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79631652
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78861337
49CLOCK_20551151_ChIP-Seq_293T_Human1.75947968
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73811819
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71741308
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70160730
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68719266
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68044518
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.66116635
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65100265
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.64106746
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63854078
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.63489477
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61822608
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61066052
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58448712
63* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57930230
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55318020
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52812236
66CIITA_25753668_ChIP-Seq_RAJI_Human1.52684199
67ELK1_19687146_ChIP-ChIP_HELA_Human1.52259778
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.51429240
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50559363
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49298766
71MYC_22102868_ChIP-Seq_BL_Human1.47949115
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45566921
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44886582
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43669865
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42124570
76* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41590934
77* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40365355
78KDM5A_27292631_Chip-Seq_BREAST_Human1.40302666
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38656469
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.38466161
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38377149
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38328447
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33281370
84ATF3_27146783_Chip-Seq_COLON_Human1.32020051
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31038765
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30469211
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.29793005
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28192293
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27459279
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26794501
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22800130
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21450649
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19042171
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18313455
95RACK7_27058665_Chip-Seq_MCF-7_Human1.16815716
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16286214
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16060771
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14975576
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14108205
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12833149
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.12491289
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12214839
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11282894
104LXR_22292898_ChIP-Seq_THP-1_Human1.07277135
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06782502
106TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06717613
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06070507
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05561139
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04141247
110* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03524072
111TFEB_21752829_ChIP-Seq_HELA_Human1.02638593
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01604058
113MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01476874
114* MYC_18940864_ChIP-ChIP_HL60_Human1.01203967
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00807663
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00546706
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00211756
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99881880
119* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99681990
120TP53_22127205_ChIP-Seq_IMR90_Human0.98943047
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.97466614
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96432684
123VDR_21846776_ChIP-Seq_THP-1_Human0.96093384
124SPI1_23547873_ChIP-Seq_NB4_Human0.95235309
125NCOR1_26117541_ChIP-Seq_K562_Human0.94734990
126* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93655817
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92364532
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90506081
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89487367
130ELK1_22589737_ChIP-Seq_MCF10A_Human0.89096528
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82353263
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82102918
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.80983290
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80282423
135SCL_19346495_ChIP-Seq_HPC-7_Human0.80087199
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79175123
137* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74356815
138* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74075929
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73978455
140NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73267100
141SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71880055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.70458384
2MP0003693_abnormal_embryo_hatching5.40655977
3MP0010094_abnormal_chromosome_stability4.54813571
4MP0004957_abnormal_blastocyst_morpholog4.35555555
5MP0003111_abnormal_nucleus_morphology4.24001744
6MP0008057_abnormal_DNA_replication4.03295821
7MP0003077_abnormal_cell_cycle3.90980260
8MP0008058_abnormal_DNA_repair3.41800346
9MP0003705_abnormal_hypodermis_morpholog3.36242871
10MP0002396_abnormal_hematopoietic_system3.22992854
11MP0004272_abnormal_basement_membrane3.06953277
12MP0008007_abnormal_cellular_replicative2.98015463
13MP0005257_abnormal_intraocular_pressure2.96338525
14MP0003123_paternal_imprinting2.92875105
15MP0003566_abnormal_cell_adhesion2.69973743
16MP0008932_abnormal_embryonic_tissue2.60860586
17MP0005275_abnormal_skin_tensile2.54450880
18MP0003279_aneurysm2.44837922
19MP0005503_abnormal_tendon_morphology2.41138784
20MP0003786_premature_aging2.24048883
21MP0001730_embryonic_growth_arrest2.18116165
22MP0008877_abnormal_DNA_methylation2.13414997
23MP0003191_abnormal_cellular_cholesterol2.12063511
24MP0001958_emphysema2.10276937
25MP0000350_abnormal_cell_proliferation2.08503686
26MP0005058_abnormal_lysosome_morphology2.03219272
27MP0000490_abnormal_crypts_of1.93826970
28MP0010368_abnormal_lymphatic_system1.93754485
29MP0003718_maternal_effect1.91240736
30MP0002060_abnormal_skin_morphology1.88327089
31MP0004808_abnormal_hematopoietic_stem1.87386560
32MP0002877_abnormal_melanocyte_morpholog1.84960618
33MP0005023_abnormal_wound_healing1.84772162
34MP0001542_abnormal_bone_strength1.77149408
35MP0010352_gastrointestinal_tract_polyps1.75085831
36MP0003567_abnormal_fetal_cardiomyocyte1.71943601
37MP0001697_abnormal_embryo_size1.71767548
38MP0001545_abnormal_hematopoietic_system1.70885472
39MP0005397_hematopoietic_system_phenotyp1.70885472
40MP0005380_embryogenesis_phenotype1.69764326
41MP0001672_abnormal_embryogenesis/_devel1.69764326
42MP0006292_abnormal_olfactory_placode1.61405171
43MP0001243_abnormal_dermal_layer1.61223611
44MP0005623_abnormal_meninges_morphology1.55743391
45MP0002080_prenatal_lethality1.54478456
46MP0003984_embryonic_growth_retardation1.52950395
47MP0000313_abnormal_cell_death1.51787299
48MP0002088_abnormal_embryonic_growth/wei1.48575316
49MP0010030_abnormal_orbit_morphology1.47440976
50MP0003121_genomic_imprinting1.46132390
51MP0003315_abnormal_perineum_morphology1.45938191
52MP0003950_abnormal_plasma_membrane1.45887471
53MP0002085_abnormal_embryonic_tissue1.45029884
54MP0001661_extended_life_span1.42135919
55MP0005464_abnormal_platelet_physiology1.41937674
56MP0009840_abnormal_foam_cell1.41268414
57MP0003091_abnormal_cell_migration1.40096862
58MP0002019_abnormal_tumor_incidence1.39243629
59MP0002086_abnormal_extraembryonic_tissu1.38048796
60MP0001293_anophthalmia1.37046405
61MP0005075_abnormal_melanosome_morpholog1.35125526
62MP0005508_abnormal_skeleton_morphology1.34176408
63MP0002084_abnormal_developmental_patter1.33805995
64MP0010307_abnormal_tumor_latency1.31303663
65MP0002210_abnormal_sex_determination1.29955260
66MP0001849_ear_inflammation1.27927785
67MP0008260_abnormal_autophagy1.25555383
68MP0009333_abnormal_splenocyte_physiolog1.24992013
69MP0000767_abnormal_smooth_muscle1.21189758
70MP0004197_abnormal_fetal_growth/weight/1.21134158
71MP0002295_abnormal_pulmonary_circulatio1.19839089
72MP0002938_white_spotting1.19460533
73MP0001145_abnormal_male_reproductive1.14462168
74MP0003763_abnormal_thymus_physiology1.10175811
75MP0000013_abnormal_adipose_tissue1.08632198
76MP0005165_increased_susceptibility_to1.07965165
77MP0009384_cardiac_valve_regurgitation1.07182767
78MP0009697_abnormal_copulation1.06413151
79MP0005501_abnormal_skin_physiology1.04627634
80MP0006054_spinal_hemorrhage1.04451834
81MP0003941_abnormal_skin_development1.04041874
82MP0001348_abnormal_lacrimal_gland1.03197615
83MP0009053_abnormal_anal_canal1.02807735
84MP0003436_decreased_susceptibility_to1.01842266
85MP0000653_abnormal_sex_gland1.00145742
86MP0000762_abnormal_tongue_morphology0.99813053
87MP0000003_abnormal_adipose_tissue0.98991800
88MP0001119_abnormal_female_reproductive0.97804558
89MP0003300_gastrointestinal_ulcer0.97627214
90MP0001929_abnormal_gametogenesis0.97389956
91MP0004233_abnormal_muscle_weight0.97379054
92MP0002722_abnormal_immune_system0.96603700
93MP0005193_abnormal_anterior_eye0.96322313
94MP0000689_abnormal_spleen_morphology0.96006554
95MP0002398_abnormal_bone_marrow0.95760972
96MP0000751_myopathy0.95141195
97MP0000703_abnormal_thymus_morphology0.94796868
98MP0003448_altered_tumor_morphology0.94478660
99MP0005390_skeleton_phenotype0.94231935
100MP0005197_abnormal_uvea_morphology0.94065291
101MP0002095_abnormal_skin_pigmentation0.93532477
102MP0000358_abnormal_cell_content/0.92160935
103MP0002896_abnormal_bone_mineralization0.91164321
104MP0003890_abnormal_embryonic-extraembry0.91120870
105MP0005174_abnormal_tail_pigmentation0.90379920
106MP0005451_abnormal_body_composition0.86504907
107MP0009379_abnormal_foot_pigmentation0.85846828
108MP0002132_abnormal_respiratory_system0.85684988
109MP0003186_abnormal_redox_activity0.85214967
110MP0002160_abnormal_reproductive_system0.85075088
111MP0004264_abnormal_extraembryonic_tissu0.84599608
112MP0003943_abnormal_hepatobiliary_system0.84504733
113MP0001216_abnormal_epidermal_layer0.84050818
114MP0004147_increased_porphyrin_level0.82901084
115MP0000343_altered_response_to0.82828161
116MP0003119_abnormal_digestive_system0.82552536
117MP0000537_abnormal_urethra_morphology0.82357623
118MP0002102_abnormal_ear_morphology0.82092093
119MP0006036_abnormal_mitochondrial_physio0.81760524
120MP0003806_abnormal_nucleotide_metabolis0.80888348
121MP0005164_abnormal_response_to0.79621037
122MP0008995_early_reproductive_senescence0.79613135
123MP0000733_abnormal_muscle_development0.79268876
124MP0003453_abnormal_keratinocyte_physiol0.77964074
125MP0002429_abnormal_blood_cell0.76320505
126MP0003937_abnormal_limbs/digits/tail_de0.76222374
127MP0001533_abnormal_skeleton_physiology0.76118445
128MP0004185_abnormal_adipocyte_glucose0.74868363
129MP0002111_abnormal_tail_morphology0.74858720
130MP0005408_hypopigmentation0.74724892
131MP0002254_reproductive_system_inflammat0.74093634
132MP0005389_reproductive_system_phenotype0.73309914
133MP0005384_cellular_phenotype0.73288011
134MP0004947_skin_inflammation0.73051250
135MP0003942_abnormal_urinary_system0.72926802
136MP0001881_abnormal_mammary_gland0.72156601
137MP0003221_abnormal_cardiomyocyte_apopto0.72091364
138MP0006035_abnormal_mitochondrial_morpho0.71862276
139MP0002796_impaired_skin_barrier0.71456553
140MP0002128_abnormal_blood_circulation0.71237706
141MP0005330_cardiomyopathy0.71027860
142MP0002249_abnormal_larynx_morphology0.71011584
143MP0000467_abnormal_esophagus_morphology0.70560088
144MP0000465_gastrointestinal_hemorrhage0.70014038
145MP0005076_abnormal_cell_differentiation0.69788726
146MP0009278_abnormal_bone_marrow0.69734334
147MP0003795_abnormal_bone_structure0.69270683
148MP0002113_abnormal_skeleton_development0.68728831
149MP0002089_abnormal_postnatal_growth/wei0.68530990
150MP0004134_abnormal_chest_morphology0.67956791
151MP0001299_abnormal_eye_distance/0.67945092
152MP0000858_altered_metastatic_potential0.66220500
153MP0000428_abnormal_craniofacial_morphol0.65880194
154MP0000685_abnormal_immune_system0.65844697
155MP0000049_abnormal_middle_ear0.65628967
156MP0001915_intracranial_hemorrhage0.65148067
157MP0000477_abnormal_intestine_morphology0.62694723
158MP0001853_heart_inflammation0.61497778
159MP0002114_abnormal_axial_skeleton0.61428121
160MP0002075_abnormal_coat/hair_pigmentati0.61214696
161MP0005621_abnormal_cell_physiology0.60436083
162MP0004084_abnormal_cardiac_muscle0.60259996
163MP0000566_synostosis0.59446445
164MP0003699_abnormal_female_reproductive0.59064795
165MP0009672_abnormal_birth_weight0.57913415
166MP0000716_abnormal_immune_system0.56254075
167MP0001919_abnormal_reproductive_system0.53801043
168MP0002092_abnormal_eye_morphology0.53361415
169MP0002932_abnormal_joint_morphology0.53335795

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.43449268
2Protrusio acetabuli (HP:0003179)6.14620186
3Birth length less than 3rd percentile (HP:0003561)5.39695996
4Aplastic anemia (HP:0001915)4.77831662
5Abnormality of cells of the erythroid lineage (HP:0012130)4.48625051
6Reticulocytopenia (HP:0001896)4.47099314
7Abnormal number of erythroid precursors (HP:0012131)4.46374497
8Vertebral compression fractures (HP:0002953)4.43091564
9Breast hypoplasia (HP:0003187)4.07586563
10Chromsome breakage (HP:0040012)3.92505298
11Oral leukoplakia (HP:0002745)3.81492344
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73874257
13Selective tooth agenesis (HP:0001592)3.50878192
14Colon cancer (HP:0003003)3.50753040
15Atrophic scars (HP:0001075)3.49417627
16Aortic dissection (HP:0002647)3.48981444
17Ankle contracture (HP:0006466)3.45954653
18Patellar aplasia (HP:0006443)3.43628025
19Cervical subluxation (HP:0003308)3.41607817
20Fragile skin (HP:0001030)3.26392157
21Aplasia/Hypoplasia of the patella (HP:0006498)3.24661307
22Meckel diverticulum (HP:0002245)3.21409553
23Abnormality of the preputium (HP:0100587)3.13856509
24Vascular tortuosity (HP:0004948)3.12094062
25Abnormality of the ileum (HP:0001549)3.11979205
26Rough bone trabeculation (HP:0100670)3.11253997
27Abnormality of dentin (HP:0010299)3.07498325
28Abnormality of chromosome stability (HP:0003220)3.06367610
29Myelodysplasia (HP:0002863)3.05740255
30Microretrognathia (HP:0000308)3.05182473
31Soft skin (HP:0000977)3.00768514
32Medulloblastoma (HP:0002885)2.94035617
33Premature graying of hair (HP:0002216)2.90886034
34Pallor (HP:0000980)2.89115889
35Bladder diverticulum (HP:0000015)2.88312333
36Cerebral hypomyelination (HP:0006808)2.87647836
37Short nail (HP:0001799)2.82200334
38Macrocytic anemia (HP:0001972)2.82079256
39Aortic aneurysm (HP:0004942)2.81307595
40Degeneration of anterior horn cells (HP:0002398)2.80205492
41Abnormality of the anterior horn cell (HP:0006802)2.80205492
42Spinal rigidity (HP:0003306)2.78917824
43Arterial tortuosity (HP:0005116)2.77306815
44Absent thumb (HP:0009777)2.77293172
45Thrombocytosis (HP:0001894)2.77177247
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.75505947
47Biconcave vertebral bodies (HP:0004586)2.73012923
48Blue sclerae (HP:0000592)2.72510976
49Carpal bone hypoplasia (HP:0001498)2.65999033
50Dilatation of the ascending aorta (HP:0005111)2.57989143
51Follicular hyperkeratosis (HP:0007502)2.57726349
52Bone marrow hypocellularity (HP:0005528)2.56563313
53Supernumerary spleens (HP:0009799)2.53697634
54Small intestinal stenosis (HP:0012848)2.53626558
55Duodenal stenosis (HP:0100867)2.53626558
56Wormian bones (HP:0002645)2.52474824
57Absent radius (HP:0003974)2.47766004
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.45487839
59Osteolytic defects of the hand bones (HP:0009699)2.45487839
60Pancytopenia (HP:0001876)2.45233085
61Type I transferrin isoform profile (HP:0003642)2.44365238
62Type 2 muscle fiber atrophy (HP:0003554)2.40791399
63Muscle fiber atrophy (HP:0100295)2.40331704
64Abnormal delivery (HP:0001787)2.39975445
65Premature ovarian failure (HP:0008209)2.38307573
66Ependymoma (HP:0002888)2.37940211
67Syringomyelia (HP:0003396)2.37055129
68Spinal cord lesions (HP:0100561)2.37055129
69Absent forearm bone (HP:0003953)2.37047641
70Aplasia involving forearm bones (HP:0009822)2.37047641
71Rhabdomyosarcoma (HP:0002859)2.35992553
72Abnormality of the acetabulum (HP:0003170)2.35982430
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35354520
74Neoplasm of the pancreas (HP:0002894)2.34184003
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33681827
76Agnosia (HP:0010524)2.32578260
77Abnormal number of incisors (HP:0011064)2.32490789
7811 pairs of ribs (HP:0000878)2.29699559
79Joint stiffness (HP:0001387)2.28945606
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.27938164
81Reduced subcutaneous adipose tissue (HP:0003758)2.26248616
82Generalized amyotrophy (HP:0003700)2.24349715
83Spondylolisthesis (HP:0003302)2.23333550
84Abnormality of alanine metabolism (HP:0010916)2.22787688
85Hyperalaninemia (HP:0003348)2.22787688
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22787688
87Abnormal trabecular bone morphology (HP:0100671)2.22359414
88Redundant skin (HP:0001582)2.22176987
89Triphalangeal thumb (HP:0001199)2.21738944
90Elbow flexion contracture (HP:0002987)2.21261829
91Abnormal lung lobation (HP:0002101)2.21196521
92Impulsivity (HP:0100710)2.21100359
93Progressive muscle weakness (HP:0003323)2.19402670
94Breech presentation (HP:0001623)2.14347943
95Tracheoesophageal fistula (HP:0002575)2.14003691
96Abnormality of the duodenum (HP:0002246)2.12914139
97Joint laxity (HP:0001388)2.10782208
98Secondary amenorrhea (HP:0000869)2.10684338
99Amaurosis fugax (HP:0100576)2.10662747
100Sloping forehead (HP:0000340)2.09885611
101Atresia of the external auditory canal (HP:0000413)2.09250091
102Abnormality of DNA repair (HP:0003254)2.08178485
103Abnormal umbilical cord blood vessels (HP:0011403)2.06520239
104Single umbilical artery (HP:0001195)2.06520239
105Abnormality of the fetal cardiovascular system (HP:0010948)2.06520239
106Delayed cranial suture closure (HP:0000270)2.05871799
107Increased serum pyruvate (HP:0003542)2.05722425
108Horseshoe kidney (HP:0000085)2.05000221
109Cellular immunodeficiency (HP:0005374)2.04002152
110Nephroblastoma (Wilms tumor) (HP:0002667)2.03898792
111Nonimmune hydrops fetalis (HP:0001790)2.03614150
112Achilles tendon contracture (HP:0001771)2.02923247
113Abnormality of glycolysis (HP:0004366)2.02544749
114Hypoplasia of the radius (HP:0002984)2.00854344
115Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00316322
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00316322
117Natal tooth (HP:0000695)1.99596179
1183-Methylglutaconic aciduria (HP:0003535)1.99450810
119Increased variability in muscle fiber diameter (HP:0003557)1.99173188
120Abnormal spermatogenesis (HP:0008669)1.98821845
121Cleft eyelid (HP:0000625)1.98329154
122Multiple enchondromatosis (HP:0005701)1.98271566
123Poikiloderma (HP:0001029)1.97583393
124Slender long bone (HP:0003100)1.96876392
125Type 1 muscle fiber predominance (HP:0003803)1.95706752
126Slender build (HP:0001533)1.95515795
127Abnormality of skeletal muscle fiber size (HP:0012084)1.95160050
128Glucose intolerance (HP:0000833)1.95076467
129Squamous cell carcinoma (HP:0002860)1.94664208
130Abnormality of carpal bone ossification (HP:0006257)1.94337383
131Disproportionate tall stature (HP:0001519)1.94241167
132Increased connective tissue (HP:0009025)1.93161172
133Thin skin (HP:0000963)1.93114209
134Clubbing of toes (HP:0100760)1.92917015
135Increased serum lactate (HP:0002151)1.92604458
136Hypertensive crisis (HP:0100735)1.92517854
137Neonatal short-limb short stature (HP:0008921)1.92290488
138Abnormality of the renal collecting system (HP:0004742)1.91961213
139Microvesicular hepatic steatosis (HP:0001414)1.91732091
140Short thumb (HP:0009778)1.90822769
141Embryonal renal neoplasm (HP:0011794)1.89725638
142Trismus (HP:0000211)1.89202179
143Sparse eyelashes (HP:0000653)1.88908103
144Genu recurvatum (HP:0002816)1.88416017
145Peritonitis (HP:0002586)1.87839942
146Basal cell carcinoma (HP:0002671)1.87698439
147Abnormality of the Achilles tendon (HP:0005109)1.87438772
148CNS hypomyelination (HP:0003429)1.86756835
149Entropion (HP:0000621)1.86748781
150Lymphoma (HP:0002665)1.86511244
151Acute lymphatic leukemia (HP:0006721)1.86424301
152Duplicated collecting system (HP:0000081)1.86188543
153Abnormality of the carotid arteries (HP:0005344)1.85963881
154Onycholysis (HP:0001806)1.84901210
155Abnormality of the labia minora (HP:0012880)1.81819739
156Ectopic kidney (HP:0000086)1.80236375
157Hyperextensible skin (HP:0000974)1.78918196
158Upper limb amyotrophy (HP:0009129)1.77256287
159Distal upper limb amyotrophy (HP:0007149)1.77256287
160IgM deficiency (HP:0002850)1.77050922
161Reduced antithrombin III activity (HP:0001976)1.76174816
162Abnormality of the tricuspid valve (HP:0001702)1.75860041
163Abnormality of the umbilical cord (HP:0010881)1.75171086
164Mitral regurgitation (HP:0001653)1.72981965
165Aortic regurgitation (HP:0001659)1.72618188
166Premature skin wrinkling (HP:0100678)1.71537613
167Dysostosis multiplex (HP:0000943)1.68661565
168Mitral stenosis (HP:0001718)1.67136135
169Mitral valve prolapse (HP:0001634)1.66921629
170Bowel diverticulosis (HP:0005222)1.65563569
171Cholecystitis (HP:0001082)1.65495740
172Abnormal gallbladder physiology (HP:0012438)1.65495740
173Abnormalities of placenta or umbilical cord (HP:0001194)1.64674068
174Orthostatic hypotension (HP:0001278)1.64170031
175Mucopolysacchariduria (HP:0008155)1.63727327
176Urinary glycosaminoglycan excretion (HP:0003541)1.63727327
177Abnormal ossification of hand bones (HP:0005921)1.62693014
178Renal duplication (HP:0000075)1.61942904
179Testicular atrophy (HP:0000029)1.61734343
180Abnormality of the distal phalanges of the toes (HP:0010182)1.61659029
181Long palpebral fissure (HP:0000637)1.60497911
182Abnormality of skull ossification (HP:0002703)1.59790301
183Cutaneous melanoma (HP:0012056)1.59435801
184Cerebral aneurysm (HP:0004944)1.59278443
185Mildly elevated creatine phosphokinase (HP:0008180)1.59243527
186Aneurysm (HP:0002617)1.58773000
187Ulnar bowing (HP:0003031)1.58128341
188Delayed closure of the anterior fontanelle (HP:0001476)1.57583680
189Beaking of vertebral bodies (HP:0004568)1.56176022
190Broad metatarsal (HP:0001783)1.55702086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.74340116
2BUB14.35685299
3CDC73.81423846
4EIF2AK13.05600630
5NME22.85784679
6STK162.84899038
7ACVR1B2.79276973
8NEK22.46369216
9IRAK32.44540388
10ERN12.40519186
11SRPK12.40288668
12PLK42.39848866
13TSSK62.27483469
14MKNK12.26844271
15TESK12.25689017
16TTK2.24724055
17MYLK2.10568491
18BRSK22.08323204
19CDK72.04065620
20VRK22.02002264
21PDGFRA1.96611132
22PLK11.96133777
23EIF2AK31.87030316
24MKNK21.86701515
25CDK81.86412546
26TRIB31.86073082
27VRK11.83347129
28PTK21.72662135
29NEK11.72347739
30DYRK31.69336769
31LIMK11.69209456
32ARAF1.66887505
33TGFBR11.62976912
34ATR1.62930884
35RPS6KB21.61931813
36PBK1.60548203
37AURKB1.60274213
38CHEK21.57388281
39SMG11.55699225
40PRPF4B1.50763387
41MOS1.47897424
42CCNB11.46560467
43MET1.39975293
44TGFBR21.37342473
45RIPK11.36899350
46MST1R1.35101657
47PIM21.28893078
48CDK41.28848339
49EEF2K1.28290921
50EPHA21.26408346
51BRSK11.25869555
52PLK31.24814192
53FLT31.22583283
54ABL21.22267600
55PAK21.21950759
56TBK11.21090868
57RPS6KA41.20439620
58MAPKAPK31.20002611
59PASK1.18094024
60ZAK1.18017707
61DDR21.15189017
62TTN1.13207623
63TLK11.12802732
64NTRK11.09215323
65AURKA1.08019969
66SIK11.07483625
67LMTK21.06957208
68CHEK11.05652705
69MAP3K81.04360586
70PAK40.97724169
71EPHB20.96213811
72ERBB40.96213652
73TESK20.92033441
74CDK120.89623825
75LATS10.82018590
76AKT30.81947349
77TYK20.81797993
78BRAF0.80833601
79PIM10.80283808
80BMX0.80248113
81SCYL20.79448746
82CDK190.78712977
83KDR0.77732518
84MAP3K140.76332566
85ATM0.75864157
86CDK20.75508736
87STK100.74616328
88MUSK0.71998944
89CSNK2A10.71285062
90EIF2AK20.71022133
91FGFR40.68493053
92CLK10.67589101
93PAK10.66645551
94CSNK2A20.66500310
95MATK0.64618275
96MST40.63194791
97ICK0.62440679
98TEC0.61876723
99STK40.61154085
100TAOK20.60859893
101MAP3K60.60371959
102MAP3K30.60130893
103PRKD20.59707177
104MAP3K120.59392564
105MAP3K110.59058458
106DAPK30.57109489
107DAPK10.56487984
108MAPKAPK20.55633055
109ZAP700.54087483
110PKN20.54027969
111STK30.53914984
112BCKDK0.53398547
113KIT0.53006530
114RAF10.51997443
115MTOR0.51446960
116BTK0.50437159
117IRAK40.49429350
118ROCK20.49229593
119ILK0.48755754
120CDK90.47906383
121CDK10.47864333
122MAP2K30.47532873
123STK38L0.46939888
124MELK0.46722267
125EPHB10.46154768
126TRPM70.45845296
127DYRK20.45122518
128LATS20.44323606
129LRRK20.44199587
130PTK60.43703379
131PTK2B0.43287543
132PIK3CG0.42680377
133AKT20.42174823
134MAP4K10.42161466
135MAPK110.40663019
136NEK90.39494548
137PRKCI0.38317207
138JAK10.37599560
139BMPR20.37454841
140STK240.37007900
141CDK60.33756062
142YES10.33425576
143BRD40.33399574
144CSF1R0.30677135
145ALK0.28296976
146TIE10.28023208
147NME10.27353044
148RPS6KA50.27096072
149JAK30.25961675
150CSNK1G30.23967408
151MAP3K100.22992376
152CSNK1G10.22256126
153MAP2K60.20987757
154CSNK1E0.20455711

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14645258
2Mismatch repair_Homo sapiens_hsa034304.38673946
3Ribosome_Homo sapiens_hsa030103.81070893
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79679594
5RNA polymerase_Homo sapiens_hsa030203.53711088
6Base excision repair_Homo sapiens_hsa034103.27861026
7Spliceosome_Homo sapiens_hsa030403.20128824
8Homologous recombination_Homo sapiens_hsa034403.12766998
9Proteasome_Homo sapiens_hsa030503.10495631
10RNA transport_Homo sapiens_hsa030133.07509295
11Nucleotide excision repair_Homo sapiens_hsa034202.97729965
12Cell cycle_Homo sapiens_hsa041102.74645690
13* Pyrimidine metabolism_Homo sapiens_hsa002402.66884343
14Fanconi anemia pathway_Homo sapiens_hsa034602.33487089
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32192022
16Fatty acid elongation_Homo sapiens_hsa000622.28565101
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18742168
18One carbon pool by folate_Homo sapiens_hsa006702.17646147
19Other glycan degradation_Homo sapiens_hsa005112.16435540
20RNA degradation_Homo sapiens_hsa030182.10878264
21Basal transcription factors_Homo sapiens_hsa030222.09111613
22Non-homologous end-joining_Homo sapiens_hsa034501.91543710
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.83735473
24ECM-receptor interaction_Homo sapiens_hsa045121.69553959
25p53 signaling pathway_Homo sapiens_hsa041151.58157804
26mRNA surveillance pathway_Homo sapiens_hsa030151.57971156
27Purine metabolism_Homo sapiens_hsa002301.55405017
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45949345
29Folate biosynthesis_Homo sapiens_hsa007901.36846545
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33609554
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24979304
32Focal adhesion_Homo sapiens_hsa045101.21541240
33Sulfur metabolism_Homo sapiens_hsa009201.14748043
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14022069
35Pyruvate metabolism_Homo sapiens_hsa006201.12143502
36Vitamin B6 metabolism_Homo sapiens_hsa007501.08738566
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08372508
38Epstein-Barr virus infection_Homo sapiens_hsa051691.05674883
39Proteoglycans in cancer_Homo sapiens_hsa052051.04935574
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.97676033
41Herpes simplex infection_Homo sapiens_hsa051680.96974967
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88831054
43Oocyte meiosis_Homo sapiens_hsa041140.88220285
44Pentose phosphate pathway_Homo sapiens_hsa000300.84526184
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83274543
46Sulfur relay system_Homo sapiens_hsa041220.79093861
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77893439
48Complement and coagulation cascades_Homo sapiens_hsa046100.75957014
49Lysosome_Homo sapiens_hsa041420.74512983
50Biosynthesis of amino acids_Homo sapiens_hsa012300.74253884
51Thyroid cancer_Homo sapiens_hsa052160.74165810
52Pancreatic cancer_Homo sapiens_hsa052120.72881799
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.72824108
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71784158
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71623719
56Vibrio cholerae infection_Homo sapiens_hsa051100.71598753
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67978136
58Viral carcinogenesis_Homo sapiens_hsa052030.67948943
59Amoebiasis_Homo sapiens_hsa051460.67772412
60Systemic lupus erythematosus_Homo sapiens_hsa053220.65994036
61Protein export_Homo sapiens_hsa030600.65395436
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63681887
63HTLV-I infection_Homo sapiens_hsa051660.61101642
64Antigen processing and presentation_Homo sapiens_hsa046120.61068552
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60447357
66Huntingtons disease_Homo sapiens_hsa050160.59390688
67N-Glycan biosynthesis_Homo sapiens_hsa005100.59112784
68Fructose and mannose metabolism_Homo sapiens_hsa000510.58977717
69Prion diseases_Homo sapiens_hsa050200.58610448
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57646832
71Selenocompound metabolism_Homo sapiens_hsa004500.54939294
72Tyrosine metabolism_Homo sapiens_hsa003500.52715839
73Salmonella infection_Homo sapiens_hsa051320.52204342
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.48484350
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48107058
76Galactose metabolism_Homo sapiens_hsa000520.47432871
77Glutathione metabolism_Homo sapiens_hsa004800.47349873
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47014576
79Small cell lung cancer_Homo sapiens_hsa052220.46635080
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.46422625
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45548384
82Parkinsons disease_Homo sapiens_hsa050120.44348328
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43749627
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43459432
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43110867
86Adherens junction_Homo sapiens_hsa045200.42789160
87Endocytosis_Homo sapiens_hsa041440.42489633
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42304398
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41274578
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40942575
91Protein digestion and absorption_Homo sapiens_hsa049740.40431640
92Pertussis_Homo sapiens_hsa051330.40371414
93MicroRNAs in cancer_Homo sapiens_hsa052060.39863913
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38748280
95Legionellosis_Homo sapiens_hsa051340.38586670
96TGF-beta signaling pathway_Homo sapiens_hsa043500.36743945
97Carbon metabolism_Homo sapiens_hsa012000.35223326
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35026265
99Hippo signaling pathway_Homo sapiens_hsa043900.34277544
100Melanoma_Homo sapiens_hsa052180.33362093
101Toxoplasmosis_Homo sapiens_hsa051450.32580028
102Measles_Homo sapiens_hsa051620.32488035
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32051514
104Apoptosis_Homo sapiens_hsa042100.31861914
105Shigellosis_Homo sapiens_hsa051310.31446249
106Colorectal cancer_Homo sapiens_hsa052100.31204633
107Notch signaling pathway_Homo sapiens_hsa043300.31192268
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30378179
109Primary immunodeficiency_Homo sapiens_hsa053400.30244425
110* Metabolic pathways_Homo sapiens_hsa011000.29502620
111Arachidonic acid metabolism_Homo sapiens_hsa005900.29120984
112Regulation of autophagy_Homo sapiens_hsa041400.28075900
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27221622
114Hepatitis B_Homo sapiens_hsa051610.26741351
115Basal cell carcinoma_Homo sapiens_hsa052170.26514253
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21946553
117HIF-1 signaling pathway_Homo sapiens_hsa040660.21281594
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20914873
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20852220
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.19433950
121Renin-angiotensin system_Homo sapiens_hsa046140.19323909
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18825537
123Pathways in cancer_Homo sapiens_hsa052000.18443389
124Influenza A_Homo sapiens_hsa051640.17853635
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17515133
126Hematopoietic cell lineage_Homo sapiens_hsa046400.17322875
127Acute myeloid leukemia_Homo sapiens_hsa052210.15870286
128Bladder cancer_Homo sapiens_hsa052190.15026261
129Wnt signaling pathway_Homo sapiens_hsa043100.11928402
130Alcoholism_Homo sapiens_hsa050340.11278197
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.10188877
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09772329
133Hedgehog signaling pathway_Homo sapiens_hsa043400.09437996
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08805422
135Chronic myeloid leukemia_Homo sapiens_hsa052200.08145609
136Oxidative phosphorylation_Homo sapiens_hsa001900.07174001
137mTOR signaling pathway_Homo sapiens_hsa041500.06440711

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