DCTN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.02288493
2protein retention in ER lumen (GO:0006621)4.52703067
3negative regulation of microtubule polymerization (GO:0031115)4.30682192
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18962219
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14337222
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.13461679
7synaptic vesicle exocytosis (GO:0016079)4.07756862
8regulation of synapse structural plasticity (GO:0051823)4.07273574
9glutamate secretion (GO:0014047)4.02785700
10layer formation in cerebral cortex (GO:0021819)3.93076017
11postsynaptic membrane organization (GO:0001941)3.76875599
12cell migration in hindbrain (GO:0021535)3.63418244
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.59581285
14positive regulation of mitochondrial fission (GO:0090141)3.51835189
15regulation of synaptic vesicle exocytosis (GO:2000300)3.48866592
16vocalization behavior (GO:0071625)3.47687833
17locomotory exploration behavior (GO:0035641)3.47451039
18activation of protein kinase A activity (GO:0034199)3.43920469
19substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.42085385
20substrate-independent telencephalic tangential migration (GO:0021826)3.42085385
21presynaptic membrane organization (GO:0097090)3.27991794
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.22897803
23proline transport (GO:0015824)3.22216183
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.21799016
25short-term memory (GO:0007614)3.21403316
26neuron cell-cell adhesion (GO:0007158)3.20705548
27neuronal action potential propagation (GO:0019227)3.18697168
28detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.18224547
29detection of temperature stimulus involved in sensory perception (GO:0050961)3.18224547
30negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.17871145
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.14246913
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11288078
33protein localization to synapse (GO:0035418)3.10772324
34neurotransmitter secretion (GO:0007269)3.09541178
35regulation of synaptic vesicle transport (GO:1902803)3.08104624
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08030149
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01201558
38detection of temperature stimulus (GO:0016048)3.00104716
39cell communication by electrical coupling (GO:0010644)2.99156292
40mating behavior (GO:0007617)2.96164757
41calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.93304097
42neuron projection extension (GO:1990138)2.92541005
43presynaptic membrane assembly (GO:0097105)2.90803491
44sodium ion export (GO:0071436)2.90756590
45neuron projection extension involved in neuron projection guidance (GO:1902284)2.90635294
46axon extension involved in axon guidance (GO:0048846)2.90635294
47regulation of neuronal synaptic plasticity (GO:0048168)2.89393446
48peptidyl-arginine omega-N-methylation (GO:0035247)2.87291941
49exploration behavior (GO:0035640)2.86809327
50axon cargo transport (GO:0008088)2.86734660
51protein neddylation (GO:0045116)2.86441717
52retinal ganglion cell axon guidance (GO:0031290)2.83150510
53innervation (GO:0060384)2.83057239
54plasma membrane repair (GO:0001778)2.82698545
55calcium ion-dependent exocytosis (GO:0017156)2.73807107
56regulation of glutamate receptor signaling pathway (GO:1900449)2.73099741
57establishment of mitochondrion localization (GO:0051654)2.72671551
58synapse assembly (GO:0007416)2.72460679
59neuron recognition (GO:0008038)2.72414119
60auditory behavior (GO:0031223)2.71295980
61COPI coating of Golgi vesicle (GO:0048205)2.70378796
62Golgi transport vesicle coating (GO:0048200)2.70378796
63cellular potassium ion homeostasis (GO:0030007)2.70028775
64neurotransmitter-gated ion channel clustering (GO:0072578)2.67459286
65acrosome reaction (GO:0007340)2.66298522
66positive regulation of synapse maturation (GO:0090129)2.65826944
67dendrite morphogenesis (GO:0048813)2.65398211
68gamma-aminobutyric acid transport (GO:0015812)2.65396087
69cerebral cortex radially oriented cell migration (GO:0021799)2.64712790
70ganglion development (GO:0061548)2.62048543
71axonal fasciculation (GO:0007413)2.61236820
72positive regulation of synapse assembly (GO:0051965)2.61156421
73cerebellar Purkinje cell layer development (GO:0021680)2.60296568
74regulation of long-term neuronal synaptic plasticity (GO:0048169)2.60224786
75histone arginine methylation (GO:0034969)2.60015702
76glycosphingolipid biosynthetic process (GO:0006688)2.59691218
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58592956
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58527955
79pyrimidine nucleobase catabolic process (GO:0006208)2.57768296
80peptidyl-arginine methylation (GO:0018216)2.57707812
81peptidyl-arginine N-methylation (GO:0035246)2.57707812
82cell communication involved in cardiac conduction (GO:0086065)2.57325896
83glycine transport (GO:0015816)2.57000167
84dendritic spine morphogenesis (GO:0060997)2.54157182
85regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.53599464
86dendritic spine organization (GO:0097061)2.53335627
87cullin deneddylation (GO:0010388)2.53311791
88response to auditory stimulus (GO:0010996)2.52104619
89organelle transport along microtubule (GO:0072384)2.51980008
90regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.51855819
91growth hormone secretion (GO:0030252)2.51432256
92alanine transport (GO:0032328)2.51367322
93neuromuscular process controlling balance (GO:0050885)2.50995159
94membrane depolarization during action potential (GO:0086010)2.50932490
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.49575058
96protein insertion into membrane (GO:0051205)2.49544081
97protein targeting to plasma membrane (GO:0072661)2.49227877
98cytoskeleton-dependent intracellular transport (GO:0030705)2.48989768
99positive regulation of axon extension (GO:0045773)2.47549806
100neurotransmitter transport (GO:0006836)2.47233815
101peptidyl-cysteine modification (GO:0018198)2.45504584
102synaptic vesicle endocytosis (GO:0048488)2.44896991
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43790669
104ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.42850909
105calcium-mediated signaling using intracellular calcium source (GO:0035584)2.42494854
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.42144624
107regulation of vesicle fusion (GO:0031338)2.40149519
108axon extension (GO:0048675)2.38753997
109regulation of dendritic spine morphogenesis (GO:0061001)2.38530891
110ATP hydrolysis coupled proton transport (GO:0015991)2.38332816
111energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.38332816
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.37190627
113transmission of nerve impulse (GO:0019226)2.36947660
114neuromuscular process controlling posture (GO:0050884)2.35948670
115neurofilament cytoskeleton organization (GO:0060052)2.34904295
116clathrin coat assembly (GO:0048268)2.34631057
117glycolytic process (GO:0006096)2.33621519
118synaptic transmission, glutamatergic (GO:0035249)2.32849216
119vesicle transport along microtubule (GO:0047496)2.32807104
120regulation of amyloid precursor protein catabolic process (GO:1902991)2.32602626
121neuromuscular synaptic transmission (GO:0007274)2.32540641
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.32066670
123mitochondrion transport along microtubule (GO:0047497)2.32066670
124ephrin receptor signaling pathway (GO:0048013)2.31930926
125de novo posttranslational protein folding (GO:0051084)2.31406003
126cellular sodium ion homeostasis (GO:0006883)2.30389216
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.30267477
128sequestering of actin monomers (GO:0042989)2.30016342
129cholesterol biosynthetic process (GO:0006695)2.29429046
130neuronal ion channel clustering (GO:0045161)2.29421635
131intraciliary transport (GO:0042073)2.29230976
132regulation of neurotransmitter levels (GO:0001505)2.28799976
133microtubule-based transport (GO:0010970)2.28335044
134synapse organization (GO:0050808)2.27939131
135protein maturation by protein folding (GO:0022417)2.27512208
136nucleobase catabolic process (GO:0046113)2.26882645
137positive regulation of potassium ion transport (GO:0043268)2.26792849
138retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.25714895
139positive regulation of synaptic transmission, GABAergic (GO:0032230)2.25638786
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.25407133
141neuromuscular process (GO:0050905)2.23767259
142membrane repolarization (GO:0086009)2.23644141
143dendrite development (GO:0016358)2.22909836
144regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.22709860
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.22695684
146positive regulation of dendritic spine development (GO:0060999)2.22339285
147neuron-neuron synaptic transmission (GO:0007270)2.21693952
148mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.21592304
149positive regulation of membrane potential (GO:0045838)2.21406968
150regulation of mitochondrial fission (GO:0090140)2.17635420
151nonmotile primary cilium assembly (GO:0035058)2.15937617
152hippocampus development (GO:0021766)2.15713071
153lens fiber cell development (GO:0070307)2.15652317
154protein deneddylation (GO:0000338)2.14813149
155cranial nerve morphogenesis (GO:0021602)2.14281630
156negative regulation of axon guidance (GO:1902668)2.14226750
157de novo protein folding (GO:0006458)2.13686280
158substantia nigra development (GO:0021762)2.12268557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72671021
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72882361
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62460876
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58620748
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46063705
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43968418
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43968418
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36680644
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36648191
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34651706
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27376808
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20505949
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16705867
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.15815903
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14721345
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14098600
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12421393
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11173181
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.11066538
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10844357
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.08660577
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04814040
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.04485276
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.01139302
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.99667745
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.98452634
27ZNF263_19887448_ChIP-Seq_K562_Human1.95729180
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.95428362
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.94538124
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86236526
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80047856
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.78796566
33DROSHA_22980978_ChIP-Seq_HELA_Human1.78514390
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73246861
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71642884
36XRN2_22483619_ChIP-Seq_HELA_Human1.69889987
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68127485
38LXR_22292898_ChIP-Seq_THP-1_Human1.62924026
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62821906
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61423177
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59583148
42* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59048875
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57595248
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.57495083
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55893418
46ZNF274_21170338_ChIP-Seq_K562_Hela1.54910276
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49230074
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48616311
49CTCF_27219007_Chip-Seq_Bcells_Human1.47703347
50KDM2B_26808549_Chip-Seq_K562_Human1.47690127
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47091038
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.46148432
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42968141
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42765141
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42447382
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.41431339
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40630072
58* ETS1_20019798_ChIP-Seq_JURKAT_Human1.37615887
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35148367
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.35104660
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35010992
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.34127098
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33873179
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30769332
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28427862
66GBX2_23144817_ChIP-Seq_PC3_Human1.25758931
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25581022
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25283480
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24603945
70GABP_19822575_ChIP-Seq_HepG2_Human1.24044136
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.23986226
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23552158
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22774883
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21256532
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20982798
76* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20834418
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.20816736
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20096851
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19969357
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18933955
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.18140666
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16852740
83SMC4_20622854_ChIP-Seq_HELA_Human1.16109303
84* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16081734
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14731431
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13853535
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13328673
88* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12930029
89MYC_18555785_ChIP-Seq_MESCs_Mouse1.11560851
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11555006
91* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11524292
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11380729
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10157554
94RNF2_27304074_Chip-Seq_NSC_Mouse1.10062313
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06309405
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05761980
97TTF2_22483619_ChIP-Seq_HELA_Human1.04768150
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.02871580
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02518042
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01412504
101* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01399378
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01156688
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.00517635
104* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99942941
105CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99495660
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99009639
107KLF4_19829295_ChIP-Seq_ESCs_Human0.98015785
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.97744986
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.96509127
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.95815710
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95242643
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.94216102
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93680357
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.93561164
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93206450
116P68_20966046_ChIP-Seq_HELA_Human0.92673957
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.92644075
118TP63_22573176_ChIP-Seq_HFKS_Human0.91845755
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91611446
120RACK7_27058665_Chip-Seq_MCF-7_Human0.90956045
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90316458
122CREB1_26743006_Chip-Seq_LNCaP_Human0.89439801
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88709284
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88113953
125OCT4_19829295_ChIP-Seq_ESCs_Human0.87843340
126* SA1_27219007_Chip-Seq_ERYTHROID_Human0.87833200
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85980823
128CTCF_20526341_ChIP-Seq_ESCs_Human0.83722817
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.83557861
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83432316
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81742199
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81632490
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80878372
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.80561911
135SMC3_22415368_ChIP-Seq_MEFs_Mouse0.78391768
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78237641
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77546920
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.77229250
139BCOR_27268052_Chip-Seq_Bcells_Human0.76872965
140* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.76729507
141AHR_22903824_ChIP-Seq_MCF-7_Human0.76585758
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76306514
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76171365
144AR_21572438_ChIP-Seq_LNCaP_Human0.75895542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.96836188
2MP0004270_analgesia3.40143673
3MP0004858_abnormal_nervous_system3.37762087
4MP0001968_abnormal_touch/_nociception3.08001237
5MP0003635_abnormal_synaptic_transmissio2.97375025
6MP0003329_amyloid_beta_deposits2.87863442
7MP0002735_abnormal_chemical_nociception2.73515818
8MP0002736_abnormal_nociception_after2.73362828
9MP0003880_abnormal_central_pattern2.71552840
10MP0005499_abnormal_olfactory_system2.61316710
11MP0005394_taste/olfaction_phenotype2.61316710
12MP0002733_abnormal_thermal_nociception2.46410674
13MP0008789_abnormal_olfactory_epithelium2.45909540
14MP0002063_abnormal_learning/memory/cond2.35397718
15MP0002734_abnormal_mechanical_nocicepti2.31965042
16MP0005410_abnormal_fertilization2.28479770
17MP0002064_seizures2.20357283
18MP0009745_abnormal_behavioral_response2.16593673
19MP0000751_myopathy2.15000614
20MP0002837_dystrophic_cardiac_calcinosis2.12857237
21MP0001970_abnormal_pain_threshold2.08563760
22MP0006276_abnormal_autonomic_nervous1.99785641
23MP0010030_abnormal_orbit_morphology1.95882683
24MP0005623_abnormal_meninges_morphology1.95279544
25MP0002272_abnormal_nervous_system1.93873068
26MP0006292_abnormal_olfactory_placode1.91830391
27MP0009046_muscle_twitch1.89139022
28MP0002572_abnormal_emotion/affect_behav1.86816113
29MP0009780_abnormal_chondrocyte_physiolo1.82768279
30MP0002184_abnormal_innervation1.77214600
31MP0002909_abnormal_adrenal_gland1.74097789
32MP0004811_abnormal_neuron_physiology1.70568420
33MP0000955_abnormal_spinal_cord1.66407815
34MP0003123_paternal_imprinting1.65675931
35MP0001440_abnormal_grooming_behavior1.64842234
36MP0005257_abnormal_intraocular_pressure1.63730399
37MP0000778_abnormal_nervous_system1.62446614
38MP0002822_catalepsy1.50344069
39MP0000566_synostosis1.48941600
40MP0000049_abnormal_middle_ear1.47496714
41MP0002067_abnormal_sensory_capabilities1.47246296
42MP0003879_abnormal_hair_cell1.44949813
43MP0005423_abnormal_somatic_nervous1.43411551
44MP0001188_hyperpigmentation1.41652373
45MP0000604_amyloidosis1.40411220
46MP0008569_lethality_at_weaning1.33628878
47MP0008961_abnormal_basal_metabolism1.33545331
48MP0001486_abnormal_startle_reflex1.32364621
49MP0003121_genomic_imprinting1.32020725
50MP0000747_muscle_weakness1.29165949
51MP0002882_abnormal_neuron_morphology1.25408333
52MP0003861_abnormal_nervous_system1.25046438
53MP0003634_abnormal_glial_cell1.24908279
54MP0003787_abnormal_imprinting1.22730845
55MP0002066_abnormal_motor_capabilities/c1.21734211
56MP0002234_abnormal_pharynx_morphology1.20716966
57MP0003633_abnormal_nervous_system1.20442766
58MP0004233_abnormal_muscle_weight1.18992166
59MP0002557_abnormal_social/conspecific_i1.18654273
60MP0008438_abnormal_cutaneous_collagen1.18604081
61MP0004130_abnormal_muscle_cell1.17222972
62MP0004145_abnormal_muscle_electrophysio1.16463690
63MP0001348_abnormal_lacrimal_gland1.16237113
64MP0000013_abnormal_adipose_tissue1.14771806
65MP0000749_muscle_degeneration1.14770518
66MP0002653_abnormal_ependyma_morphology1.14055931
67MP0003385_abnormal_body_wall1.13878161
68MP0010234_abnormal_vibrissa_follicle1.12955085
69MP0001905_abnormal_dopamine_level1.12665955
70MP0002233_abnormal_nose_morphology1.10996227
71MP0001501_abnormal_sleep_pattern1.10908827
72MP0000920_abnormal_myelination1.10185743
73MP0004924_abnormal_behavior1.07432892
74MP0005386_behavior/neurological_phenoty1.07432892
75MP0002938_white_spotting1.07296800
76MP0003631_nervous_system_phenotype1.06711436
77MP0000631_abnormal_neuroendocrine_gland1.05832430
78MP0001293_anophthalmia1.05421590
79MP0003755_abnormal_palate_morphology1.04435129
80MP0005083_abnormal_biliary_tract1.03937587
81MP0004133_heterotaxia1.03801119
82MP0001346_abnormal_lacrimal_gland1.02292461
83MP0005187_abnormal_penis_morphology1.01437811
84MP0002269_muscular_atrophy1.00306298
85MP0002163_abnormal_gland_morphology0.97504245
86MP0003938_abnormal_ear_development0.96761592
87MP0010386_abnormal_urinary_bladder0.96592595
88MP0003283_abnormal_digestive_organ0.96146839
89MP0001984_abnormal_olfaction0.95595796
90MP0002152_abnormal_brain_morphology0.95567582
91MP0000462_abnormal_digestive_system0.94896264
92MP0008932_abnormal_embryonic_tissue0.93912498
93MP0004142_abnormal_muscle_tone0.93783816
94MP0005248_abnormal_Harderian_gland0.93661761
95MP0000750_abnormal_muscle_regeneration0.92760484
96MP0003632_abnormal_nervous_system0.92708489
97MP0004885_abnormal_endolymph0.92456085
98MP0000026_abnormal_inner_ear0.91342423
99MP0000534_abnormal_ureter_morphology0.90209201
100MP0004147_increased_porphyrin_level0.90116955
101MP0003122_maternal_imprinting0.89065002
102MP0003705_abnormal_hypodermis_morpholog0.86950929
103MP0001529_abnormal_vocalization0.86277589
104MP0009053_abnormal_anal_canal0.84739950
105MP0001958_emphysema0.83691057
106MP0005167_abnormal_blood-brain_barrier0.83631678
107MP0000759_abnormal_skeletal_muscle0.83049998
108MP0002229_neurodegeneration0.82762203
109MP0003045_fibrosis0.82440520
110MP0002069_abnormal_eating/drinking_beha0.81618521
111MP0000579_abnormal_nail_morphology0.81483384
112MP0004085_abnormal_heartbeat0.80603902
113MP0004272_abnormal_basement_membrane0.79001176
114MP0004036_abnormal_muscle_relaxation0.78801165
115MP0004215_abnormal_myocardial_fiber0.77915233
116MP0000537_abnormal_urethra_morphology0.77487418
117MP0005275_abnormal_skin_tensile0.77355212
118MP0002081_perinatal_lethality0.76568355
119MP0001502_abnormal_circadian_rhythm0.75372866
120MP0003137_abnormal_impulse_conducting0.75009012
121MP0003315_abnormal_perineum_morphology0.74767976
122MP0003690_abnormal_glial_cell0.74452309
123MP0002697_abnormal_eye_size0.73194851
124MP0002177_abnormal_outer_ear0.72726039
125MP0002752_abnormal_somatic_nervous0.72586473
126MP0003279_aneurysm0.70815541
127MP0002116_abnormal_craniofacial_bone0.70182130
128MP0008874_decreased_physiological_sensi0.69822777
129MP0002249_abnormal_larynx_morphology0.69041531
130MP0003119_abnormal_digestive_system0.68507275
131MP0004087_abnormal_muscle_fiber0.68502378
132MP0003937_abnormal_limbs/digits/tail_de0.67827997
133MP0003942_abnormal_urinary_system0.67735217
134MP0005620_abnormal_muscle_contractility0.65743268
135MP0009384_cardiac_valve_regurgitation0.65447302
136MP0002092_abnormal_eye_morphology0.65205850
137MP0001299_abnormal_eye_distance/0.65026204
138MP0001849_ear_inflammation0.63309194
139MP0005330_cardiomyopathy0.62223935
140MP0002751_abnormal_autonomic_nervous0.61618020
141MP0005535_abnormal_body_temperature0.61270931
142MP0001270_distended_abdomen0.60700981
143MP0003698_abnormal_male_reproductive0.60653595

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.22448746
2Supranuclear gaze palsy (HP:0000605)3.94187660
3Termporal pattern (HP:0011008)3.90412855
4Insidious onset (HP:0003587)3.90412855
5Cortical dysplasia (HP:0002539)3.89630135
6Cerebral inclusion bodies (HP:0100314)3.62349872
7Neurofibrillary tangles (HP:0002185)3.56707840
8Visual hallucinations (HP:0002367)3.21585915
9Ankle clonus (HP:0011448)3.21100818
10Focal seizures (HP:0007359)3.09388736
11Pheochromocytoma (HP:0002666)3.07810963
12Action tremor (HP:0002345)3.05706309
13Abnormality of the lower motor neuron (HP:0002366)2.98941028
14Focal motor seizures (HP:0011153)2.95836882
15Gait imbalance (HP:0002141)2.78608255
16Urinary urgency (HP:0000012)2.74729084
17Abnormality of the corticospinal tract (HP:0002492)2.73367467
18Spastic gait (HP:0002064)2.72450546
19Progressive cerebellar ataxia (HP:0002073)2.71771129
20Insomnia (HP:0100785)2.70731436
21Neuroendocrine neoplasm (HP:0100634)2.69050837
22Distal upper limb amyotrophy (HP:0007149)2.66872562
23Upper limb amyotrophy (HP:0009129)2.66872562
24Impaired vibration sensation in the lower limbs (HP:0002166)2.62593986
25Hypercortisolism (HP:0001578)2.51240634
26Exercise-induced muscle cramps (HP:0003710)2.49671841
27Hand muscle atrophy (HP:0009130)2.47923468
28Hammertoe (HP:0001765)2.47506892
29Ulnar claw (HP:0001178)2.45171483
30Congenital primary aphakia (HP:0007707)2.43442078
31Hyporeflexia of lower limbs (HP:0002600)2.42945851
32Premature rupture of membranes (HP:0001788)2.39052221
33Myotonia (HP:0002486)2.39002267
34Lower limb muscle weakness (HP:0007340)2.38618953
35Rapidly progressive (HP:0003678)2.38247338
36Nephrogenic diabetes insipidus (HP:0009806)2.37316739
37Urinary bladder sphincter dysfunction (HP:0002839)2.37054428
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35791988
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.35791988
40Depression (HP:0000716)2.34315942
41Scanning speech (HP:0002168)2.29656613
42Achilles tendon contracture (HP:0001771)2.26789802
43Poor suck (HP:0002033)2.24005079
44Amblyopia (HP:0000646)2.23611631
45Torticollis (HP:0000473)2.22819773
46Difficulty running (HP:0009046)2.22366130
47Increased variability in muscle fiber diameter (HP:0003557)2.21861392
48Hypoventilation (HP:0002791)2.18083715
49Abnormal gallbladder physiology (HP:0012438)2.17040675
50Cholecystitis (HP:0001082)2.17040675
51Postural instability (HP:0002172)2.16936339
52Epileptic encephalopathy (HP:0200134)2.16352095
53Abnormality of the Achilles tendon (HP:0005109)2.14771144
54Limb dystonia (HP:0002451)2.14712580
55Foot dorsiflexor weakness (HP:0009027)2.13013598
56Turricephaly (HP:0000262)2.12551102
57Dysmetria (HP:0001310)2.11475710
58Neoplasm of the peripheral nervous system (HP:0100007)2.10678108
59Abnormal eating behavior (HP:0100738)2.09804375
60Sudden death (HP:0001699)2.09221020
61Abnormality of dentin (HP:0010299)2.07372565
62Megalencephaly (HP:0001355)2.06546774
63Medial flaring of the eyebrow (HP:0010747)2.05663453
64Delusions (HP:0000746)2.04280955
65Upper limb muscle weakness (HP:0003484)2.03767365
66Abnormality of glycolysis (HP:0004366)2.03364555
67Lissencephaly (HP:0001339)2.02129957
68Atonic seizures (HP:0010819)2.01911377
69Focal dystonia (HP:0004373)2.01673359
70Truncal ataxia (HP:0002078)2.00788515
71Generalized tonic-clonic seizures (HP:0002069)2.00441663
72Cerebral aneurysm (HP:0004944)2.00319914
73Retinal dysplasia (HP:0007973)2.00143666
74Neuronal loss in central nervous system (HP:0002529)1.99313679
75Bowel diverticulosis (HP:0005222)1.99287129
76Craniofacial dystonia (HP:0012179)1.98571602
77Difficulty climbing stairs (HP:0003551)1.98484045
78Abnormality of the foot musculature (HP:0001436)1.97830414
79Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97722479
80Hypoplasia of the brainstem (HP:0002365)1.97722479
81Anxiety (HP:0000739)1.97097000
82Dysdiadochokinesis (HP:0002075)1.96163525
83Acute necrotizing encephalopathy (HP:0006965)1.94122867
84Exercise-induced myalgia (HP:0003738)1.92666282
85Buphthalmos (HP:0000557)1.92355717
86Intention tremor (HP:0002080)1.90867518
87Abnormal mitochondria in muscle tissue (HP:0008316)1.90175988
88Poor eye contact (HP:0000817)1.90162586
89Bladder diverticulum (HP:0000015)1.89533921
90Abnormality of pain sensation (HP:0010832)1.89393893
91Impaired pain sensation (HP:0007328)1.89393893
92Pachygyria (HP:0001302)1.88979233
93Distal sensory impairment (HP:0002936)1.88728317
94Impaired social interactions (HP:0000735)1.86998019
95Abnormal social behavior (HP:0012433)1.86998019
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.86727262
97Absent/shortened dynein arms (HP:0200106)1.86727262
98Clonus (HP:0002169)1.86289830
99Lower limb amyotrophy (HP:0007210)1.85699130
100Polyphagia (HP:0002591)1.85233176
101Drooling (HP:0002307)1.83808672
102Adrenal hypoplasia (HP:0000835)1.83528166
103Vaginal atresia (HP:0000148)1.83488454
104Specific learning disability (HP:0001328)1.83484738
105Onion bulb formation (HP:0003383)1.82121559
106Mutism (HP:0002300)1.82008066
107Cerebral hypomyelination (HP:0006808)1.81947505
108Myoglobinuria (HP:0002913)1.81795851
109Morphological abnormality of the pyramidal tract (HP:0002062)1.81572326
110Abnormality of the vocal cords (HP:0008777)1.80273738
111Absence seizures (HP:0002121)1.78791726
112Double outlet right ventricle (HP:0001719)1.78754640
113Congenital malformation of the right heart (HP:0011723)1.78754640
114Increased serum pyruvate (HP:0003542)1.78603188
115Spastic tetraplegia (HP:0002510)1.78482909
116Slow progression (HP:0003677)1.78467557
117Failure to thrive in infancy (HP:0001531)1.76718445
118Muscle stiffness (HP:0003552)1.76002475
119Ventricular fibrillation (HP:0001663)1.75191295
120Emotional lability (HP:0000712)1.74993842
121Rigidity (HP:0002063)1.74329687
122Labial hypoplasia (HP:0000066)1.73179450
123Abnormality of skeletal muscle fiber size (HP:0012084)1.72942365
124Decreased motor nerve conduction velocity (HP:0003431)1.72734182
125CNS hypomyelination (HP:0003429)1.72627516
126Acute encephalopathy (HP:0006846)1.68956523
127Abnormality of the aortic arch (HP:0012303)1.68701037
128Postural tremor (HP:0002174)1.68055523
129Genital tract atresia (HP:0001827)1.67498471
130Split foot (HP:0001839)1.67468775
131Bronchomalacia (HP:0002780)1.66980552
132Cerebral hemorrhage (HP:0001342)1.66657259
133Cholelithiasis (HP:0001081)1.65764292
134Hyperacusis (HP:0010780)1.65749448
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.65574178
136Hypoplastic female external genitalia (HP:0012815)1.65272680
137Abnormality of the diencephalon (HP:0010662)1.64745887
138Gait ataxia (HP:0002066)1.64489496
139Reticulocytosis (HP:0001923)1.64083885
140Oligodactyly (HP:0012165)1.63979761
141Broad distal phalanx of finger (HP:0009836)1.63866483
142Optic nerve coloboma (HP:0000588)1.63064724
143High anterior hairline (HP:0009890)1.62544117
144Broad foot (HP:0001769)1.61470327
145Delayed gross motor development (HP:0002194)1.60240925
146Bifid tongue (HP:0010297)1.59457679
147Decreased testicular size (HP:0008734)1.59330117
148Abnormality of the motor neurons (HP:0002450)1.59126231
149Abnormal neuron morphology (HP:0012757)1.59126231
150Polymicrogyria (HP:0002126)1.58991553
151Excessive salivation (HP:0003781)1.57331069
152Overriding aorta (HP:0002623)1.57192690
153Aplasia/Hypoplasia of the lens (HP:0008063)1.56630317
154Type II lissencephaly (HP:0007260)1.56168908
155Limb-girdle muscle atrophy (HP:0003797)1.55487632
156Renal duplication (HP:0000075)1.53330103
157Agitation (HP:0000713)1.53124100
158Abnormal gallbladder morphology (HP:0012437)1.53031686
159Occipital encephalocele (HP:0002085)1.52705368
160Poor coordination (HP:0002370)1.52344256
161Trigonocephaly (HP:0000243)1.51384519
162Abnormality of the labia (HP:0000058)1.50621439
163Hyperglycinemia (HP:0002154)1.50421315
164Hemivertebrae (HP:0002937)1.49925613
165Hypoplasia of the corpus callosum (HP:0002079)1.49645541
166Hyperthyroidism (HP:0000836)1.49374871
167Long toe (HP:0010511)1.49280011
168Shoulder girdle muscle weakness (HP:0003547)1.49123005
169Down-sloping shoulders (HP:0200021)1.49052508
170Amyotrophic lateral sclerosis (HP:0007354)1.48708769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K92.88723517
2BCR2.69579731
3NTRK12.64674403
4TRIM282.51581122
5PRKD32.48641283
6KSR22.42175989
7CASK2.34616219
8MINK12.32835867
9MARK12.32611585
10NTRK32.28885663
11PAK62.26296572
12TRIB32.19838340
13LIMK12.05812190
14LMTK22.02385803
15TESK11.96540933
16DAPK21.91147315
17PDK31.90313181
18PDK41.90313181
19CAMKK21.78852522
20CAMKK11.73684634
21MAP4K21.70579904
22NTRK21.70050683
23ARAF1.68677413
24EPHA41.66220393
25LATS21.65428636
26PHKG21.64802515
27PHKG11.64802515
28MAP3K41.60625364
29ICK1.54086235
30STK161.50070672
31SIK31.45592657
32WNK41.41244447
33TYRO31.35831281
34PTK2B1.34108508
35GRK51.33717917
36PIM21.32665861
37EPHA31.31138988
38CSNK1A1L1.30549421
39MAP2K41.27881694
40MAP3K21.27596580
41FER1.27347621
42CAMK1G1.24848272
43KSR11.23854787
44DDR21.23662729
45UHMK11.23294299
46BRAF1.23145232
47DYRK31.19532526
48RET1.19124897
49CDK51.18923506
50PAK31.18048925
51NEK11.17600731
52SRPK11.14502158
53CDK141.12678564
54STK391.10710369
55MAP3K121.07714946
56TIE11.06057635
57CDK151.04710289
58PDGFRA1.03339334
59CDK181.02632720
60CSNK1G11.01872508
61DAPK31.01655974
62MAPK131.01033844
63STK380.99266681
64MAP2K10.97277677
65PNCK0.95863421
66CDK11A0.92863356
67CDK190.92664779
68PKN20.91598137
69CAMK1D0.91224552
70PDK20.89437169
71WNK30.87839272
72SCYL20.86513912
73MAPKAPK30.84755187
74PRKCH0.84038303
75TESK20.83900616
76MAP2K70.81173548
77PRKCG0.80970989
78ROCK20.77596498
79PTK20.76222059
80TAOK10.75440969
81PINK10.74996646
82SIK20.74382858
83WNK10.73758299
84MAPKAPK50.73542463
85PAK40.73280915
86MAP3K10.72772585
87BRSK10.72388495
88DAPK10.70349727
89TTN0.68344845
90AURKA0.67815418
91CSNK1G20.66937498
92PKN10.66601940
93EPHB20.66353028
94DYRK1A0.66179661
95ILK0.66175088
96MATK0.66135662
97RPS6KA40.63556298
98RIPK10.63294258
99RIPK40.63180903
100CAMK2A0.62899909
101PDPK10.62191888
102EEF2K0.61584207
103MARK20.60118604
104PLK20.59424315
105BMX0.56761904
106PRKCZ0.56591188
107CAMK2B0.56150680
108CAMK2G0.54953963
109BCKDK0.54741432
110OXSR10.54179593
111MAP3K110.53509559
112PAK10.52661825
113CAMK2D0.52590915
114SGK2230.52383050
115SGK4940.52383050
116PRKCI0.51501906
117CAMK10.51269211
118PTK60.50923961
119LRRK20.50406548
120ERBB30.50236358
121DYRK20.49754324
122DYRK1B0.49516746
123PRKD10.49308997
124RPS6KA20.48705808
125CSNK1G30.48552143
126MOS0.48474581
127EIF2AK10.48058669
128MAP3K60.46980139
129ABL20.45813622
130EPHB10.45434871
131CSNK1A10.45430977
132CDK80.43727443
133ROCK10.42582300
134PRKCE0.40343565
135MYLK0.39553476
136NME20.38674727

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.95691291
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.68838767
3* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09831325
4Steroid biosynthesis_Homo sapiens_hsa001002.01537313
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81561731
6Circadian entrainment_Homo sapiens_hsa047131.79008681
7Long-term potentiation_Homo sapiens_hsa047201.75816958
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74969292
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69394624
10GABAergic synapse_Homo sapiens_hsa047271.69359898
11Nicotine addiction_Homo sapiens_hsa050331.66172803
12Dopaminergic synapse_Homo sapiens_hsa047281.60919573
13Olfactory transduction_Homo sapiens_hsa047401.58410990
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58185005
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.57050209
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53460225
17Glutamatergic synapse_Homo sapiens_hsa047241.52710587
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50677293
19Amphetamine addiction_Homo sapiens_hsa050311.49581706
20Insulin secretion_Homo sapiens_hsa049111.48919693
21Sulfur relay system_Homo sapiens_hsa041221.48004041
22Salivary secretion_Homo sapiens_hsa049701.47875856
23Collecting duct acid secretion_Homo sapiens_hsa049661.47521321
24Gastric acid secretion_Homo sapiens_hsa049711.47229239
25Nitrogen metabolism_Homo sapiens_hsa009101.46077168
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45343907
27Cardiac muscle contraction_Homo sapiens_hsa042601.43072027
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42745342
29Pyruvate metabolism_Homo sapiens_hsa006201.40440011
30Gap junction_Homo sapiens_hsa045401.34007536
31Cholinergic synapse_Homo sapiens_hsa047251.33082676
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28755435
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24102362
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21178990
35Pentose phosphate pathway_Homo sapiens_hsa000301.21125887
36Morphine addiction_Homo sapiens_hsa050321.20698444
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17820927
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17178112
39Vibrio cholerae infection_Homo sapiens_hsa051101.16450559
40Taste transduction_Homo sapiens_hsa047421.16413010
41Oxytocin signaling pathway_Homo sapiens_hsa049211.15196669
42Renin secretion_Homo sapiens_hsa049241.14973261
43Fructose and mannose metabolism_Homo sapiens_hsa000511.13369106
44GnRH signaling pathway_Homo sapiens_hsa049121.12286015
45Axon guidance_Homo sapiens_hsa043601.09965381
46Estrogen signaling pathway_Homo sapiens_hsa049151.07235095
47Galactose metabolism_Homo sapiens_hsa000521.06789246
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04385378
49Glioma_Homo sapiens_hsa052141.03947773
50Basal cell carcinoma_Homo sapiens_hsa052171.03764906
51Oxidative phosphorylation_Homo sapiens_hsa001901.03281091
52Parkinsons disease_Homo sapiens_hsa050121.03070518
53Arginine and proline metabolism_Homo sapiens_hsa003301.02787175
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02033727
55Long-term depression_Homo sapiens_hsa047301.01464540
56Cocaine addiction_Homo sapiens_hsa050301.01157359
57Butanoate metabolism_Homo sapiens_hsa006501.00024509
58Hippo signaling pathway_Homo sapiens_hsa043900.99797527
59Bile secretion_Homo sapiens_hsa049760.98250913
60Melanogenesis_Homo sapiens_hsa049160.97853939
61Serotonergic synapse_Homo sapiens_hsa047260.97578639
62Protein export_Homo sapiens_hsa030600.97318573
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96721695
64Alzheimers disease_Homo sapiens_hsa050100.95706241
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94283599
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93323346
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93315210
68Calcium signaling pathway_Homo sapiens_hsa040200.93247467
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90283988
70Ribosome_Homo sapiens_hsa030100.88931881
71Fatty acid metabolism_Homo sapiens_hsa012120.87697976
72VEGF signaling pathway_Homo sapiens_hsa043700.87045328
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82420390
74Propanoate metabolism_Homo sapiens_hsa006400.82334244
75Folate biosynthesis_Homo sapiens_hsa007900.80598078
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80465901
77Dilated cardiomyopathy_Homo sapiens_hsa054140.80305914
78Glucagon signaling pathway_Homo sapiens_hsa049220.79625446
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.78991910
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78123882
81Endocytosis_Homo sapiens_hsa041440.77714556
82Fatty acid biosynthesis_Homo sapiens_hsa000610.77492316
83Proteasome_Homo sapiens_hsa030500.76633343
84Carbon metabolism_Homo sapiens_hsa012000.75488712
85Arginine biosynthesis_Homo sapiens_hsa002200.75448297
86Fatty acid degradation_Homo sapiens_hsa000710.74775445
87Dorso-ventral axis formation_Homo sapiens_hsa043200.74367004
88Phototransduction_Homo sapiens_hsa047440.72377313
89ErbB signaling pathway_Homo sapiens_hsa040120.71951314
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70823429
91Notch signaling pathway_Homo sapiens_hsa043300.70808218
92Oocyte meiosis_Homo sapiens_hsa041140.70238355
93Thyroid hormone synthesis_Homo sapiens_hsa049180.69008821
94Insulin signaling pathway_Homo sapiens_hsa049100.68788296
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68764394
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.68520980
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68487852
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68350453
99Prion diseases_Homo sapiens_hsa050200.68279450
100Type II diabetes mellitus_Homo sapiens_hsa049300.68215440
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66730787
102cAMP signaling pathway_Homo sapiens_hsa040240.66696310
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65967574
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65634962
105Pancreatic secretion_Homo sapiens_hsa049720.65199510
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.63682280
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.63336805
108Tight junction_Homo sapiens_hsa045300.61565431
109Glutathione metabolism_Homo sapiens_hsa004800.60855374
110PPAR signaling pathway_Homo sapiens_hsa033200.60663142
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.60511578
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60472057
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60045625
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.58893647
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58755351
116Fatty acid elongation_Homo sapiens_hsa000620.58487700
117Bladder cancer_Homo sapiens_hsa052190.57646446
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54553818
119Vitamin B6 metabolism_Homo sapiens_hsa007500.54318952
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54270586
121Huntingtons disease_Homo sapiens_hsa050160.52682215
122Wnt signaling pathway_Homo sapiens_hsa043100.52678520
123Alcoholism_Homo sapiens_hsa050340.51104088
124Peroxisome_Homo sapiens_hsa041460.50578848
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50487639
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50226262
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50132981
128Hedgehog signaling pathway_Homo sapiens_hsa043400.50052516
129Biosynthesis of amino acids_Homo sapiens_hsa012300.50021982
130Metabolic pathways_Homo sapiens_hsa011000.49164792
131Rap1 signaling pathway_Homo sapiens_hsa040150.48262646
132Selenocompound metabolism_Homo sapiens_hsa004500.48106697
133Adherens junction_Homo sapiens_hsa045200.47992703
134Phenylalanine metabolism_Homo sapiens_hsa003600.47711645
135Sulfur metabolism_Homo sapiens_hsa009200.45927210
136RNA polymerase_Homo sapiens_hsa030200.45793010
137Salmonella infection_Homo sapiens_hsa051320.45520572
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44742392
139AMPK signaling pathway_Homo sapiens_hsa041520.42715865
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.40406102
141beta-Alanine metabolism_Homo sapiens_hsa004100.35861756
142Regulation of autophagy_Homo sapiens_hsa041400.35420547
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34220437

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