DCTN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.55990041
2chaperone-mediated protein transport (GO:0072321)6.34381074
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00074808
4ATP synthesis coupled proton transport (GO:0015986)5.87892478
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.87892478
6respiratory electron transport chain (GO:0022904)5.48890574
7electron transport chain (GO:0022900)5.39512890
8protein neddylation (GO:0045116)5.13496891
9pyrimidine nucleobase catabolic process (GO:0006208)5.10343608
10protein complex biogenesis (GO:0070271)4.68105150
11sequestering of actin monomers (GO:0042989)4.32988278
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19369857
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.19369857
14NADH dehydrogenase complex assembly (GO:0010257)4.19369857
15mitochondrial respiratory chain complex assembly (GO:0033108)4.18326288
16nucleobase catabolic process (GO:0046113)3.99052226
17behavioral response to nicotine (GO:0035095)3.82031177
18neuron cell-cell adhesion (GO:0007158)3.81491178
19hydrogen ion transmembrane transport (GO:1902600)3.78087983
20energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.71558196
21ATP hydrolysis coupled proton transport (GO:0015991)3.71558196
22negative regulation of microtubule polymerization (GO:0031115)3.61570075
23synaptic vesicle maturation (GO:0016188)3.57825243
24neuronal action potential propagation (GO:0019227)3.52670420
25synaptic vesicle exocytosis (GO:0016079)3.48734255
26protein targeting to mitochondrion (GO:0006626)3.45533052
27mitochondrion transport along microtubule (GO:0047497)3.43540850
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.43540850
29proton transport (GO:0015992)3.36806283
30regulation of mitochondrial translation (GO:0070129)3.35119552
31establishment of protein localization to mitochondrion (GO:0072655)3.33637600
32proteasome assembly (GO:0043248)3.32699543
33GTP biosynthetic process (GO:0006183)3.31541891
34hydrogen transport (GO:0006818)3.26935017
35iron-sulfur cluster assembly (GO:0016226)3.26871951
36metallo-sulfur cluster assembly (GO:0031163)3.26871951
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25325349
38viral protein processing (GO:0019082)3.22471559
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21788238
40regulation of oxidative phosphorylation (GO:0002082)3.15144321
41protein localization to mitochondrion (GO:0070585)3.14614555
42ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.14141174
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14082851
44detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.13975684
45detection of temperature stimulus involved in sensory perception (GO:0050961)3.13975684
46mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.13610944
47central nervous system myelination (GO:0022010)3.13606893
48axon ensheathment in central nervous system (GO:0032291)3.13606893
49regulation of cilium movement (GO:0003352)3.12567402
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.12248856
51transferrin transport (GO:0033572)3.11688188
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.09758931
53ATP biosynthetic process (GO:0006754)3.06736560
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05687758
55regulation of microtubule-based movement (GO:0060632)3.03580965
56axonal fasciculation (GO:0007413)3.01122343
57platelet dense granule organization (GO:0060155)2.99637907
58dendritic spine morphogenesis (GO:0060997)2.97651327
59cytochrome complex assembly (GO:0017004)2.97639288
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.97035756
61regulation of cellular amino acid metabolic process (GO:0006521)2.96196108
62regulation of synapse structural plasticity (GO:0051823)2.95777297
63cullin deneddylation (GO:0010388)2.95193397
64protein polyglutamylation (GO:0018095)2.94527957
65neuron recognition (GO:0008038)2.93182883
66detection of temperature stimulus (GO:0016048)2.91128319
67substantia nigra development (GO:0021762)2.90890682
68protein localization to synapse (GO:0035418)2.90466094
69positive regulation of protein depolymerization (GO:1901881)2.88224532
70calcium-mediated signaling using intracellular calcium source (GO:0035584)2.87272256
71transmission of nerve impulse (GO:0019226)2.86094349
72glutamate secretion (GO:0014047)2.85734977
73positive regulation of mitochondrial fission (GO:0090141)2.85058441
74respiratory chain complex IV assembly (GO:0008535)2.84802541
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84205994
76guanosine-containing compound biosynthetic process (GO:1901070)2.84016542
77regulation of dopamine metabolic process (GO:0042053)2.81310299
78regulation of catecholamine metabolic process (GO:0042069)2.81310299
79positive regulation of TOR signaling (GO:0032008)2.80918069
80gamma-aminobutyric acid transport (GO:0015812)2.80870871
81cell migration in hindbrain (GO:0021535)2.80839297
82long-chain fatty acid biosynthetic process (GO:0042759)2.80210067
83trivalent inorganic cation transport (GO:0072512)2.79114420
84ferric iron transport (GO:0015682)2.79114420
85inner mitochondrial membrane organization (GO:0007007)2.77080183
86viral transcription (GO:0019083)2.77067021
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75953323
88presynaptic membrane assembly (GO:0097105)2.73669290
89synapse assembly (GO:0007416)2.73584911
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72449385
91negative regulation of dendrite morphogenesis (GO:0050774)2.72119297
92protein insertion into membrane (GO:0051205)2.71987339
93ubiquinone biosynthetic process (GO:0006744)2.71769156
94cotranslational protein targeting to membrane (GO:0006613)2.71368434
95protein-cofactor linkage (GO:0018065)2.70986787
96protein deneddylation (GO:0000338)2.68543178
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.67623931
98termination of RNA polymerase III transcription (GO:0006386)2.67623931
99intraciliary transport (GO:0042073)2.67596696
100regulation of synaptic vesicle exocytosis (GO:2000300)2.67525838
101ubiquinone metabolic process (GO:0006743)2.67232541
102protein targeting to ER (GO:0045047)2.67087742
103neurofilament cytoskeleton organization (GO:0060052)2.66937053
104ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66507964
105synaptic transmission, glutamatergic (GO:0035249)2.66021782
106dopamine biosynthetic process (GO:0042416)2.65348448
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65239098
108protein localization to endoplasmic reticulum (GO:0070972)2.64832691
109presynaptic membrane organization (GO:0097090)2.62662452
110negative regulation of calcium ion transport into cytosol (GO:0010523)2.60174939
111phagosome maturation (GO:0090382)2.59615836
112translational termination (GO:0006415)2.59405348
113base-excision repair, AP site formation (GO:0006285)2.59318161
114short-term memory (GO:0007614)2.59058612
115negative regulation of cation channel activity (GO:2001258)2.58023590
116regulation of synaptic vesicle transport (GO:1902803)2.57771490
117protein localization to cilium (GO:0061512)2.57520794
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55134546
119establishment of mitochondrion localization (GO:0051654)2.55016301
120deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.54721335
121ribosomal small subunit biogenesis (GO:0042274)2.54072506
122intracellular protein transmembrane import (GO:0044743)2.54070677
123negative regulation of ligase activity (GO:0051352)2.53862271
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53862271
125dendritic spine organization (GO:0097061)2.53692044
126UTP biosynthetic process (GO:0006228)2.53628748
127negative regulation of telomere maintenance (GO:0032205)2.53543517
128establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53063961
129mannosylation (GO:0097502)2.52383511
130epithelial cilium movement (GO:0003351)2.51656720
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50695617
132retinal ganglion cell axon guidance (GO:0031290)2.50593650
133negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50437228
134regulation of cellular amine metabolic process (GO:0033238)2.49965983
135GDP-mannose metabolic process (GO:0019673)2.49931217
136positive regulation of protein complex disassembly (GO:0043243)2.49893259
137nonmotile primary cilium assembly (GO:0035058)2.48107184
138synaptic transmission, dopaminergic (GO:0001963)2.47917733
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46738080
140virion assembly (GO:0019068)2.45416029
141neuronal ion channel clustering (GO:0045161)2.45388154
142exploration behavior (GO:0035640)2.45355510
143positive regulation of synapse assembly (GO:0051965)2.44159559
144neuron-neuron synaptic transmission (GO:0007270)2.44094361
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.43809143
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.43809143
147GPI anchor metabolic process (GO:0006505)2.43727287
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43616638
149protein maturation by protein folding (GO:0022417)2.43363105
150regulation of glutamate secretion (GO:0014048)2.42915190
151synaptic transmission, cholinergic (GO:0007271)2.42740123
152anterograde synaptic vesicle transport (GO:0048490)2.42226626
153dopamine transport (GO:0015872)2.41680420
154neurotransmitter secretion (GO:0007269)2.40856159
155postsynaptic membrane organization (GO:0001941)2.40795179
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.40778407
157signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.40778407
158auditory behavior (GO:0031223)2.40040476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.00728227
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82561882
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57847452
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22418159
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.10140517
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08259229
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93153105
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73676121
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69189995
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.47384501
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.36035730
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29557980
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25981436
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25947000
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24126711
16GBX2_23144817_ChIP-Seq_PC3_Human2.21578810
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20556707
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19489267
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.14325412
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10329723
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05183535
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03250118
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02380141
24VDR_22108803_ChIP-Seq_LS180_Human1.97271015
25TAF15_26573619_Chip-Seq_HEK293_Human1.90513816
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90029059
27* REST_21632747_ChIP-Seq_MESCs_Mouse1.82426310
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81629144
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.80707099
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80602562
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.79654470
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74423839
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74378193
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.71797947
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65657234
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65657234
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.64914634
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64315882
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63399101
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.60830117
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.59431421
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58171044
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56858660
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54622484
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48403124
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47928371
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47244444
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46144405
49CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.45229358
50DCP1A_22483619_ChIP-Seq_HELA_Human1.41075035
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35424320
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33925639
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33838685
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.31474779
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30957904
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30169794
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.30063775
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29849857
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27830146
60* BCL6_27268052_Chip-Seq_Bcells_Human1.23478793
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22883931
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22604547
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21839121
64VDR_23849224_ChIP-Seq_CD4+_Human1.21505140
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21039339
66CIITA_25753668_ChIP-Seq_RAJI_Human1.20602294
67IGF1R_20145208_ChIP-Seq_DFB_Human1.17704458
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.17439056
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.16144621
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.16086366
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.15981694
72RNF2_27304074_Chip-Seq_NSC_Mouse1.15496868
73TP53_22573176_ChIP-Seq_HFKS_Human1.14628048
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14479452
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.11964846
76TTF2_22483619_ChIP-Seq_HELA_Human1.10565912
77XRN2_22483619_ChIP-Seq_HELA_Human1.08976983
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07809481
79P300_19829295_ChIP-Seq_ESCs_Human1.07511348
80CTCF_20526341_ChIP-Seq_ESCs_Human1.07293018
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06590694
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06462579
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06411354
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04441356
85* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03899535
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03628621
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02855696
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01802779
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00906482
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00528786
91RARB_27405468_Chip-Seq_BRAIN_Mouse0.97380632
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97158812
93* FOXP1_21924763_ChIP-Seq_HESCs_Human0.96947608
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96605080
95CTCF_27219007_Chip-Seq_Bcells_Human0.96145464
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95838426
97GABP_19822575_ChIP-Seq_HepG2_Human0.94556145
98ERA_21632823_ChIP-Seq_H3396_Human0.94249477
99MYC_18940864_ChIP-ChIP_HL60_Human0.93675155
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93074003
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92592988
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91712968
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90102078
104STAT1_20625510_ChIP-Seq_HELA_Human0.89987775
105JUN_21703547_ChIP-Seq_K562_Human0.89374376
106NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89359812
107TAF2_19829295_ChIP-Seq_ESCs_Human0.88820183
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.88343457
109MYC_18555785_ChIP-Seq_MESCs_Mouse0.87221428
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86737527
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86093282
112PHF8_20622854_ChIP-Seq_HELA_Human0.85580137
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85155795
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85126134
115* E2F1_20622854_ChIP-Seq_HELA_Human0.84541442
116REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81697104
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81182951
118ELK1_19687146_ChIP-ChIP_HELA_Human0.81007670
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80381211
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.78079474
121ZNF274_21170338_ChIP-Seq_K562_Hela0.77392545
122NCOR_22424771_ChIP-Seq_293T_Human0.76872166
123FOXP3_21729870_ChIP-Seq_TREG_Human0.75983975
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75670247
125ER_23166858_ChIP-Seq_MCF-7_Human0.73822550
126FUS_26573619_Chip-Seq_HEK293_Human0.72124208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.78565706
2MP0004270_analgesia3.41550916
3MP0006276_abnormal_autonomic_nervous3.38845144
4MP0002735_abnormal_chemical_nociception3.29218628
5MP0001968_abnormal_touch/_nociception3.23673047
6MP0002736_abnormal_nociception_after3.06109841
7MP0002734_abnormal_mechanical_nocicepti2.91380419
8MP0004859_abnormal_synaptic_plasticity2.89683196
9MP0001529_abnormal_vocalization2.84340326
10MP0009379_abnormal_foot_pigmentation2.80050976
11MP0001905_abnormal_dopamine_level2.80024260
12MP0002733_abnormal_thermal_nociception2.79052821
13MP0001970_abnormal_pain_threshold2.69273780
14MP0001986_abnormal_taste_sensitivity2.67895242
15MP0003787_abnormal_imprinting2.65822463
16MP0002064_seizures2.40461556
17MP0002272_abnormal_nervous_system2.38405940
18MP0003635_abnormal_synaptic_transmissio2.37155766
19MP0009745_abnormal_behavioral_response2.26128285
20MP0005423_abnormal_somatic_nervous2.25047115
21MP0009046_muscle_twitch2.19861014
22MP0002822_catalepsy2.03059350
23MP0002572_abnormal_emotion/affect_behav2.00754335
24MP0002653_abnormal_ependyma_morphology1.93761855
25MP0004142_abnormal_muscle_tone1.92795834
26MP0002063_abnormal_learning/memory/cond1.89655998
27MP0002184_abnormal_innervation1.86531844
28MP0002102_abnormal_ear_morphology1.84747758
29MP0001440_abnormal_grooming_behavior1.82819851
30MP0003121_genomic_imprinting1.80691784
31MP0002751_abnormal_autonomic_nervous1.80396192
32MP0002067_abnormal_sensory_capabilities1.74999870
33MP0001486_abnormal_startle_reflex1.70315946
34MP0010386_abnormal_urinary_bladder1.69044846
35MP0001188_hyperpigmentation1.68389594
36MP0002638_abnormal_pupillary_reflex1.66846545
37MP0005171_absent_coat_pigmentation1.65147632
38MP0004742_abnormal_vestibular_system1.59488928
39MP0000372_irregular_coat_pigmentation1.58669891
40MP0001984_abnormal_olfaction1.57887209
41MP0000778_abnormal_nervous_system1.55642810
42MP0005409_darkened_coat_color1.53124409
43MP0000920_abnormal_myelination1.50190365
44MP0008260_abnormal_autophagy1.44945943
45MP0003136_yellow_coat_color1.40398711
46MP0003011_delayed_dark_adaptation1.37101166
47MP0005386_behavior/neurological_phenoty1.36526809
48MP0004924_abnormal_behavior1.36526809
49MP0002557_abnormal_social/conspecific_i1.34758087
50MP0002882_abnormal_neuron_morphology1.32304430
51MP0000955_abnormal_spinal_cord1.27318513
52MP0008877_abnormal_DNA_methylation1.25858439
53MP0005645_abnormal_hypothalamus_physiol1.25133095
54MP0001485_abnormal_pinna_reflex1.24442248
55MP0001501_abnormal_sleep_pattern1.23155035
56MP0004811_abnormal_neuron_physiology1.21183011
57MP0003122_maternal_imprinting1.18970743
58MP0002229_neurodegeneration1.18122787
59MP0003123_paternal_imprinting1.17577928
60MP0003879_abnormal_hair_cell1.16100944
61MP0002066_abnormal_motor_capabilities/c1.15858445
62MP0000750_abnormal_muscle_regeneration1.14911036
63MP0002163_abnormal_gland_morphology1.12220189
64MP0004858_abnormal_nervous_system1.12015743
65MP0002752_abnormal_somatic_nervous1.09765528
66MP0005379_endocrine/exocrine_gland_phen1.09480480
67MP0002876_abnormal_thyroid_physiology1.07152576
68MP0001963_abnormal_hearing_physiology1.06052020
69MP0002837_dystrophic_cardiac_calcinosis1.05750594
70MP0003186_abnormal_redox_activity1.05642740
71MP0006036_abnormal_mitochondrial_physio1.05032791
72MP0003329_amyloid_beta_deposits1.04893346
73MP0008569_lethality_at_weaning1.04407909
74MP0004133_heterotaxia1.02951383
75MP0003646_muscle_fatigue1.02508858
76MP0006072_abnormal_retinal_apoptosis1.00798618
77MP0004885_abnormal_endolymph0.99754716
78MP0003634_abnormal_glial_cell0.98658703
79MP0001664_abnormal_digestion0.97716799
80MP0001502_abnormal_circadian_rhythm0.96823551
81MP0000049_abnormal_middle_ear0.96680362
82MP0005646_abnormal_pituitary_gland0.96215441
83MP0003315_abnormal_perineum_morphology0.93145040
84MP0001348_abnormal_lacrimal_gland0.93117656
85MP0003137_abnormal_impulse_conducting0.90990399
86MP0008872_abnormal_physiological_respon0.89808771
87MP0006035_abnormal_mitochondrial_morpho0.88206698
88MP0008789_abnormal_olfactory_epithelium0.88114423
89MP0002928_abnormal_bile_duct0.84475009
90MP0000015_abnormal_ear_pigmentation0.83087678
91MP0002148_abnormal_hypersensitivity_rea0.81688220
92MP0001542_abnormal_bone_strength0.80948513
93MP0000026_abnormal_inner_ear0.80942777
94MP0005410_abnormal_fertilization0.80889971
95MP0005084_abnormal_gallbladder_morpholo0.78859866
96MP0005499_abnormal_olfactory_system0.77075690
97MP0005394_taste/olfaction_phenotype0.77075690
98MP0005551_abnormal_eye_electrophysiolog0.76557725
99MP0002909_abnormal_adrenal_gland0.75888709
100MP0002234_abnormal_pharynx_morphology0.75196944
101MP0003183_abnormal_peptide_metabolism0.72964463
102MP0003938_abnormal_ear_development0.72844955
103MP0008995_early_reproductive_senescence0.72830366
104MP0005083_abnormal_biliary_tract0.72761447
105MP0000751_myopathy0.72749128
106MP0000681_abnormal_thyroid_gland0.71667774
107MP0005195_abnormal_posterior_eye0.70246850
108MP0002160_abnormal_reproductive_system0.69968517
109MP0005535_abnormal_body_temperature0.68917816
110MP0002332_abnormal_exercise_endurance0.67869361
111MP0002095_abnormal_skin_pigmentation0.67538802
112MP0004381_abnormal_hair_follicle0.67119872
113MP0000631_abnormal_neuroendocrine_gland0.66686655
114MP0002069_abnormal_eating/drinking_beha0.66140774
115MP0000639_abnormal_adrenal_gland0.66054979
116MP0000749_muscle_degeneration0.65596440
117MP0003633_abnormal_nervous_system0.65592329
118MP0006292_abnormal_olfactory_placode0.65523424
119MP0004145_abnormal_muscle_electrophysio0.64907818
120MP0004147_increased_porphyrin_level0.64612883
121MP0002152_abnormal_brain_morphology0.63433103
122MP0005253_abnormal_eye_physiology0.61192491
123MP0000538_abnormal_urinary_bladder0.60916915
124MP0003631_nervous_system_phenotype0.60381900

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.25839027
2Myokymia (HP:0002411)5.91285742
3Mitochondrial inheritance (HP:0001427)5.69559506
4Abnormal mitochondria in muscle tissue (HP:0008316)5.60081066
5Progressive macrocephaly (HP:0004481)5.15785616
6Hepatocellular necrosis (HP:0001404)4.96854346
7Acute encephalopathy (HP:0006846)4.90639478
8Increased CSF lactate (HP:0002490)4.69427270
9Increased hepatocellular lipid droplets (HP:0006565)4.29013745
10Hepatic necrosis (HP:0002605)3.95950382
11Pheochromocytoma (HP:0002666)3.92738653
12Neuroendocrine neoplasm (HP:0100634)3.91342614
13Hypothermia (HP:0002045)3.87184291
14Renal Fanconi syndrome (HP:0001994)3.85962461
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.71512737
16Limb dystonia (HP:0002451)3.69833703
17Lipid accumulation in hepatocytes (HP:0006561)3.67712785
18Optic disc pallor (HP:0000543)3.45271631
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.41783966
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40062461
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40062461
22Focal motor seizures (HP:0011153)3.38376904
23Leukodystrophy (HP:0002415)3.36856103
24Respiratory failure (HP:0002878)3.31368799
253-Methylglutaconic aciduria (HP:0003535)3.27739439
26Increased intramyocellular lipid droplets (HP:0012240)3.04764308
27Exercise intolerance (HP:0003546)3.04753130
28Lactic acidosis (HP:0003128)2.97322573
29Cerebral edema (HP:0002181)2.96419329
30Exertional dyspnea (HP:0002875)2.84170009
31Increased serum lactate (HP:0002151)2.83827901
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80856768
33Cerebral hypomyelination (HP:0006808)2.80011804
34Increased serum pyruvate (HP:0003542)2.79062082
35Abnormality of glycolysis (HP:0004366)2.79062082
36Poor suck (HP:0002033)2.68861035
37Sensory axonal neuropathy (HP:0003390)2.60427680
38Molar tooth sign on MRI (HP:0002419)2.56867483
39Abnormality of midbrain morphology (HP:0002418)2.56867483
40Lissencephaly (HP:0001339)2.56386061
41Atonic seizures (HP:0010819)2.53431449
42Abnormality of renal resorption (HP:0011038)2.53313100
43Increased muscle lipid content (HP:0009058)2.45489142
44Epileptic encephalopathy (HP:0200134)2.44799831
45Emotional lability (HP:0000712)2.43077185
46Parakeratosis (HP:0001036)2.41426492
47Medial flaring of the eyebrow (HP:0010747)2.41005867
48Retinal dysplasia (HP:0007973)2.40380621
49Delusions (HP:0000746)2.39037834
50Aplasia/Hypoplasia of the brainstem (HP:0007362)2.37393956
51Hypoplasia of the brainstem (HP:0002365)2.37393956
52Pachygyria (HP:0001302)2.31467371
53X-linked dominant inheritance (HP:0001423)2.26959869
54Gait imbalance (HP:0002141)2.22456031
55Focal dystonia (HP:0004373)2.19110091
56Mutism (HP:0002300)2.18148326
57Myotonia (HP:0002486)2.17332207
58Visual hallucinations (HP:0002367)2.16603846
59Failure to thrive in infancy (HP:0001531)2.16183161
60Neoplasm of the peripheral nervous system (HP:0100007)2.15326339
61True hermaphroditism (HP:0010459)2.14025164
62Abnormal hair whorl (HP:0010721)2.13108086
63Abnormal autonomic nervous system physiology (HP:0012332)2.10382509
64Respiratory difficulties (HP:0002880)2.08579509
65Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06926162
66Febrile seizures (HP:0002373)2.06731790
67Nephronophthisis (HP:0000090)2.06429881
68Spastic tetraplegia (HP:0002510)2.06124217
69Pancreatic fibrosis (HP:0100732)2.04966001
70Focal seizures (HP:0007359)2.03927234
71Hyperphosphaturia (HP:0003109)2.03604609
72Congenital primary aphakia (HP:0007707)2.03495220
73Anxiety (HP:0000739)2.01506310
74Abnormal respiratory epithelium morphology (HP:0012253)2.01368269
75Abnormal respiratory motile cilium morphology (HP:0005938)2.01368269
76Concave nail (HP:0001598)2.00422387
77Abnormality of cells of the erythroid lineage (HP:0012130)2.00082421
78Progressive cerebellar ataxia (HP:0002073)1.99961724
79Peripheral hypomyelination (HP:0007182)1.99334014
80Craniofacial dystonia (HP:0012179)1.98966984
81Amblyopia (HP:0000646)1.98964456
82Hypsarrhythmia (HP:0002521)1.98953954
83Epileptiform EEG discharges (HP:0011182)1.97733044
84CNS demyelination (HP:0007305)1.97658946
85EEG with generalized epileptiform discharges (HP:0011198)1.96422339
86Ankle clonus (HP:0011448)1.96048059
87Progressive microcephaly (HP:0000253)1.95794066
88Abnormality of the corticospinal tract (HP:0002492)1.95742885
89Polyphagia (HP:0002591)1.93362526
90Congenital ichthyosiform erythroderma (HP:0007431)1.92573835
91Oligomenorrhea (HP:0000876)1.91781700
92Genital tract atresia (HP:0001827)1.91714243
93Abnormality of magnesium homeostasis (HP:0004921)1.91462510
94Type II lissencephaly (HP:0007260)1.91210878
95Nephrogenic diabetes insipidus (HP:0009806)1.91150436
96Torticollis (HP:0000473)1.89372695
97Vaginal atresia (HP:0000148)1.89367661
98Left ventricular hypertrophy (HP:0001712)1.88436966
99Abnormal pupillary function (HP:0007686)1.88050541
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.85521380
101Poor speech (HP:0002465)1.85432449
102Type I transferrin isoform profile (HP:0003642)1.85135323
103Absence seizures (HP:0002121)1.85036348
104Esotropia (HP:0000565)1.84964684
105Severe muscular hypotonia (HP:0006829)1.84615002
106Abnormal ciliary motility (HP:0012262)1.83818307
107Supranuclear gaze palsy (HP:0000605)1.83497664
108Dicarboxylic aciduria (HP:0003215)1.82926100
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82926100
110Pancreatic cysts (HP:0001737)1.82567030
111Dialeptic seizures (HP:0011146)1.82036931
112Muscular hypotonia of the trunk (HP:0008936)1.81531283
113Fetal akinesia sequence (HP:0001989)1.81501809
114Sclerocornea (HP:0000647)1.78982273
115Amyotrophic lateral sclerosis (HP:0007354)1.77026084
116Lethargy (HP:0001254)1.74250354
117Hemiparesis (HP:0001269)1.73540090
118Palpebral edema (HP:0100540)1.72780950
119Methylmalonic aciduria (HP:0012120)1.72162259
120Generalized tonic-clonic seizures (HP:0002069)1.71873130
121Abnormal urine phosphate concentration (HP:0012599)1.71848941
122Agitation (HP:0000713)1.70793874
123Ulnar claw (HP:0001178)1.69620504
124Hyperventilation (HP:0002883)1.67715067
125Abnormal number of erythroid precursors (HP:0012131)1.65314680
126Broad-based gait (HP:0002136)1.65276824
127Akinesia (HP:0002304)1.62209465
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.61922715
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.61922715
130Progressive inability to walk (HP:0002505)1.59045511
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58270282
132Abnormal hemoglobin (HP:0011902)1.57686817
133Abnormal eating behavior (HP:0100738)1.57444011
134Dysautonomia (HP:0002459)1.56507785
135CNS hypomyelination (HP:0003429)1.55483683
136Diminished movement (HP:0002374)1.55096679
137Renal tubular dysfunction (HP:0000124)1.54906872
138Hyperparathyroidism (HP:0000843)1.54652962
139Amniotic constriction ring (HP:0009775)1.54439636
140Abnormality of placental membranes (HP:0011409)1.54439636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF3.98067749
2CASK3.66389982
3MAP3K123.44196517
4LIMK12.84906479
5GRK52.58533157
6BCKDK2.47493230
7NME12.47178017
8MAP4K22.46105145
9PIM22.43098833
10CDK192.34704999
11TESK22.31300767
12TLK12.24546769
13STK162.07127944
14BRAF2.06614983
15MAP2K71.99756354
16NME21.93086217
17PINK11.91413896
18STK391.80835756
19PRPF4B1.77046291
20TESK11.75896678
21MARK11.73659419
22NTRK31.73590269
23TRIM281.72607279
24PAK61.57398291
25VRK21.53513047
26MINK11.50880950
27PBK1.47263567
28OXSR11.47261595
29BMPR1B1.45509301
30DYRK21.44972810
31BCR1.44617691
32GRK71.41930803
33MAPKAPK51.41540607
34UHMK11.40632082
35DYRK1B1.39862709
36SIK21.39351792
37EIF2AK11.34279207
38WNK41.32634213
39SIK31.30043649
40BUB11.28191223
41ADRBK21.24177401
42MAPK131.22759382
43NTRK21.21190239
44PLK21.16947697
45EIF2AK31.16307665
46BMPR21.13351440
47CAMK2B1.12374161
48CSNK1G31.09324897
49EPHB21.09267131
50PAK31.05222808
51MAP3K111.03613795
52MAP3K91.02171825
53NTRK11.00012310
54DAPK30.96217263
55MYLK0.93601330
56CDK140.92660822
57MST40.91808151
58CAMKK20.91577196
59TNIK0.90117763
60MAP3K40.88872589
61ADRBK10.88625207
62VRK10.88368115
63DAPK10.84887349
64EPHA40.83001670
65DYRK30.81296400
66CAMK2G0.81108056
67CDK180.79672511
68CDK50.79192792
69MUSK0.78562852
70CSNK1G20.78281557
71CAMK2D0.76445222
72CAMK2A0.76118056
73DAPK20.75781476
74RIPK40.74391998
75RPS6KA40.72839101
76RAF10.71819579
77CDK150.71564814
78PTK2B0.70212282
79CDK11A0.69901827
80PRKCE0.69232800
81KDR0.68325306
82PNCK0.67442386
83CAMKK10.67002867
84PRKCG0.66990416
85PHKG10.65492388
86PHKG20.65492388
87MAP3K20.63212463
88WNK30.62534858
89KSR20.61933885
90AURKA0.60063901
91PKN10.59819102
92ILK0.58183822
93TAOK30.58025711
94PAK10.55816374
95CAMK10.55802257
96ROCK20.55538675
97ABL20.55209859
98PRKD30.55021566
99GRK10.54194679
100SRPK10.52617872
101DYRK1A0.52504735
102CSNK1G10.52374682
103SGK4940.49564358
104SGK2230.49564358
105MAP2K40.49112009
106EPHA30.46846387
107ZAK0.46024914
108OBSCN0.45271034
109CSNK1A1L0.45019841
110IRAK10.43476090
111TNK20.41882838
112ERBB30.41710618
113YES10.40488320
114MAPKAPK30.39550570
115CSNK1A10.38287303
116PRKACA0.37977114
117FES0.37929572
118CDK80.37825491
119MAPK40.36375394
120PRKCZ0.35779287
121MAP3K10.35447482
122MAP3K60.35220951
123PRKCI0.34810507
124RPS6KA50.34344027
125MAP2K10.34283850
126RPS6KA20.32791025
127PRKCA0.31269851
128MARK20.31012204
129SYK0.29732959
130MAPK150.29228892
131MAP2K20.28853844
132CCNB10.27701543

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.95807239
2Parkinsons disease_Homo sapiens_hsa050125.12706519
3Alzheimers disease_Homo sapiens_hsa050103.86565902
4Proteasome_Homo sapiens_hsa030503.57153884
5Huntingtons disease_Homo sapiens_hsa050163.47461266
6Ribosome_Homo sapiens_hsa030103.30440610
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.99108106
8Collecting duct acid secretion_Homo sapiens_hsa049662.78357199
9Synaptic vesicle cycle_Homo sapiens_hsa047212.73698928
10Protein export_Homo sapiens_hsa030602.65690623
11Cardiac muscle contraction_Homo sapiens_hsa042602.29652994
12Vibrio cholerae infection_Homo sapiens_hsa051102.20849094
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07797345
14RNA polymerase_Homo sapiens_hsa030201.72678785
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53406990
16Serotonergic synapse_Homo sapiens_hsa047261.44181879
17Nicotine addiction_Homo sapiens_hsa050331.37047828
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27890498
19Rheumatoid arthritis_Homo sapiens_hsa053231.27673455
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25850357
21Butanoate metabolism_Homo sapiens_hsa006501.24247624
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22051613
23Olfactory transduction_Homo sapiens_hsa047401.21002824
24Phototransduction_Homo sapiens_hsa047441.15865286
25Dopaminergic synapse_Homo sapiens_hsa047281.15384263
26GABAergic synapse_Homo sapiens_hsa047271.13705725
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13667136
28Taste transduction_Homo sapiens_hsa047421.10337918
29Fatty acid elongation_Homo sapiens_hsa000621.08200543
30Circadian entrainment_Homo sapiens_hsa047131.04915554
31Peroxisome_Homo sapiens_hsa041461.04709563
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04373212
33Morphine addiction_Homo sapiens_hsa050321.03012254
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02592687
35Regulation of autophagy_Homo sapiens_hsa041401.00814152
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00738175
37Amphetamine addiction_Homo sapiens_hsa050310.99701324
38Phagosome_Homo sapiens_hsa041450.99228572
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99108695
40Sulfur metabolism_Homo sapiens_hsa009200.99043048
41Glutamatergic synapse_Homo sapiens_hsa047240.93098827
42Cholinergic synapse_Homo sapiens_hsa047250.92430735
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89026006
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85309335
45Long-term potentiation_Homo sapiens_hsa047200.82153969
46Cocaine addiction_Homo sapiens_hsa050300.81786896
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80266824
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78099082
49Ether lipid metabolism_Homo sapiens_hsa005650.77942482
50Steroid biosynthesis_Homo sapiens_hsa001000.77520618
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77438158
52Long-term depression_Homo sapiens_hsa047300.77099807
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76789034
54Insulin secretion_Homo sapiens_hsa049110.73708719
55Pyrimidine metabolism_Homo sapiens_hsa002400.73131822
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73054826
57Sphingolipid metabolism_Homo sapiens_hsa006000.71806729
58Alcoholism_Homo sapiens_hsa050340.63545162
59Salivary secretion_Homo sapiens_hsa049700.60265573
60Gap junction_Homo sapiens_hsa045400.60045258
61Purine metabolism_Homo sapiens_hsa002300.56287055
62Axon guidance_Homo sapiens_hsa043600.54912693
63Metabolic pathways_Homo sapiens_hsa011000.54494185
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53852837
65Base excision repair_Homo sapiens_hsa034100.51196634
66Type I diabetes mellitus_Homo sapiens_hsa049400.50191954
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50158928
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48141221
69Arachidonic acid metabolism_Homo sapiens_hsa005900.47907217
70Tryptophan metabolism_Homo sapiens_hsa003800.45248751
71beta-Alanine metabolism_Homo sapiens_hsa004100.43252988
72Allograft rejection_Homo sapiens_hsa053300.42975217
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41249050
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41220644
75Sulfur relay system_Homo sapiens_hsa041220.40637454
76Calcium signaling pathway_Homo sapiens_hsa040200.38783017
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38560289
78Propanoate metabolism_Homo sapiens_hsa006400.38060708
79Gastric acid secretion_Homo sapiens_hsa049710.38027882
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36518832
81Asthma_Homo sapiens_hsa053100.36198776
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35245908
83Renin secretion_Homo sapiens_hsa049240.35170106
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.35003134
85Salmonella infection_Homo sapiens_hsa051320.33333625
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33205803
87Basal transcription factors_Homo sapiens_hsa030220.32503458
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32337290
89Oxytocin signaling pathway_Homo sapiens_hsa049210.31770573
90Autoimmune thyroid disease_Homo sapiens_hsa053200.31310368
91Phenylalanine metabolism_Homo sapiens_hsa003600.29708472
92Endocytosis_Homo sapiens_hsa041440.29512670
93GnRH signaling pathway_Homo sapiens_hsa049120.29203637
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28719679
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27997584
96Pyruvate metabolism_Homo sapiens_hsa006200.27936346
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27066684
98Oocyte meiosis_Homo sapiens_hsa041140.26660299
99Melanogenesis_Homo sapiens_hsa049160.26484526
100Dilated cardiomyopathy_Homo sapiens_hsa054140.26411770
101Fatty acid metabolism_Homo sapiens_hsa012120.26270229
102Graft-versus-host disease_Homo sapiens_hsa053320.25557313
103Folate biosynthesis_Homo sapiens_hsa007900.25365089
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.24329712
105Spliceosome_Homo sapiens_hsa030400.24320504
106Carbon metabolism_Homo sapiens_hsa012000.23986318
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23569394
108RNA degradation_Homo sapiens_hsa030180.23510234
109Pancreatic secretion_Homo sapiens_hsa049720.23448258
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23329070
111Tyrosine metabolism_Homo sapiens_hsa003500.22490365
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.22212550
113Linoleic acid metabolism_Homo sapiens_hsa005910.22061152
114Glutathione metabolism_Homo sapiens_hsa004800.21695100
115Shigellosis_Homo sapiens_hsa051310.21564938
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21206416
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20996453
118Nitrogen metabolism_Homo sapiens_hsa009100.20981793
119Ras signaling pathway_Homo sapiens_hsa040140.20824987
120cAMP signaling pathway_Homo sapiens_hsa040240.18674419
121Epstein-Barr virus infection_Homo sapiens_hsa051690.17702465
122ErbB signaling pathway_Homo sapiens_hsa040120.17088124
123Lysosome_Homo sapiens_hsa041420.15691779
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13864755
125Pertussis_Homo sapiens_hsa051330.13618860
126Prion diseases_Homo sapiens_hsa050200.13237447
127Other glycan degradation_Homo sapiens_hsa005110.13101299

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