DCTN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.03770925
2cullin deneddylation (GO:0010388)4.49624558
3protein deneddylation (GO:0000338)4.45193925
4chaperone-mediated protein transport (GO:0072321)4.22223469
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04230163
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.99608966
7mitochondrial respiratory chain complex I assembly (GO:0032981)3.87323505
8NADH dehydrogenase complex assembly (GO:0010257)3.87323505
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87323505
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81257229
11ATP synthesis coupled proton transport (GO:0015986)3.81257229
12ribosomal small subunit assembly (GO:0000028)3.78701675
13positive regulation of dendritic spine morphogenesis (GO:0061003)3.78518337
14layer formation in cerebral cortex (GO:0021819)3.78250390
15protein complex biogenesis (GO:0070271)3.78246136
16protein neddylation (GO:0045116)3.77958563
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73307149
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.59351372
19regulation of cellular amino acid metabolic process (GO:0006521)3.46419584
20respiratory chain complex IV assembly (GO:0008535)3.46196790
21antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.43491348
22negative regulation of ligase activity (GO:0051352)3.42302094
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42302094
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.37350885
25mitochondrial respiratory chain complex assembly (GO:0033108)3.36986059
26neuron recognition (GO:0008038)3.35035614
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34806443
28establishment of viral latency (GO:0019043)3.31609623
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30142552
30nuclear pore complex assembly (GO:0051292)3.29607937
31cytochrome complex assembly (GO:0017004)3.24527802
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23004562
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23004562
34protein localization to synapse (GO:0035418)3.20526183
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18751247
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18751247
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18751247
38axonal fasciculation (GO:0007413)3.18418702
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18206626
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17388117
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.14607598
42cell migration in hindbrain (GO:0021535)3.13628944
43neurofilament cytoskeleton organization (GO:0060052)3.11328410
44deoxyribose phosphate biosynthetic process (GO:0046385)3.02539884
452-deoxyribonucleotide biosynthetic process (GO:0009265)3.02539884
46dopamine transport (GO:0015872)3.02026784
47glutamate secretion (GO:0014047)3.01980015
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.00015315
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00015315
50signal transduction involved in cell cycle checkpoint (GO:0072395)2.99371207
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99091560
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97363660
53paraxial mesoderm development (GO:0048339)2.97248213
54nuclear pore organization (GO:0006999)2.94380569
55termination of RNA polymerase III transcription (GO:0006386)2.94134156
56transcription elongation from RNA polymerase III promoter (GO:0006385)2.94134156
57guanosine-containing compound biosynthetic process (GO:1901070)2.89720247
587-methylguanosine mRNA capping (GO:0006370)2.89255181
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89109814
60RNA capping (GO:0036260)2.88495701
617-methylguanosine RNA capping (GO:0009452)2.88495701
62GDP-mannose metabolic process (GO:0019673)2.86348921
63establishment of integrated proviral latency (GO:0075713)2.85698188
64protein targeting to mitochondrion (GO:0006626)2.84806482
65GTP biosynthetic process (GO:0006183)2.84621314
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81565489
67negative regulation of dendrite morphogenesis (GO:0050774)2.80841852
68GMP metabolic process (GO:0046037)2.79923995
69ionotropic glutamate receptor signaling pathway (GO:0035235)2.78812250
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78253125
71postsynaptic membrane organization (GO:0001941)2.77864732
72respiratory electron transport chain (GO:0022904)2.77620552
73synaptic vesicle exocytosis (GO:0016079)2.77216977
74DNA deamination (GO:0045006)2.77102019
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76963417
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76963417
77regulation of axon extension involved in axon guidance (GO:0048841)2.76565250
78antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.73957809
79electron transport chain (GO:0022900)2.73579029
80neuron cell-cell adhesion (GO:0007158)2.72785022
81positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.72745383
82mannosylation (GO:0097502)2.72322259
83regulation of axon guidance (GO:1902667)2.71411035
84establishment of protein localization to mitochondrion (GO:0072655)2.70635490
85iron-sulfur cluster assembly (GO:0016226)2.70302147
86metallo-sulfur cluster assembly (GO:0031163)2.70302147
87mating behavior (GO:0007617)2.69985735
88positive regulation of dendrite morphogenesis (GO:0050775)2.69497672
89positive regulation of ligase activity (GO:0051351)2.67050088
90viral protein processing (GO:0019082)2.66582627
91regulation of cellular amine metabolic process (GO:0033238)2.66112762
92purine-containing compound salvage (GO:0043101)2.65559250
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64829063
94neutrophil activation involved in immune response (GO:0002283)2.63159236
95neurotransmitter-gated ion channel clustering (GO:0072578)2.62755620
96dendrite morphogenesis (GO:0048813)2.61913226
97axon extension (GO:0048675)2.60820197
98apical protein localization (GO:0045176)2.60689733
99de novo posttranslational protein folding (GO:0051084)2.60534914
100transferrin transport (GO:0033572)2.60439775
101mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.57889202
102positive regulation of synapse maturation (GO:0090129)2.57517466
103amino acid import (GO:0043090)2.56484285
104regulation of NFAT protein import into nucleus (GO:0051532)2.54026262
105deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.53185545
106positive regulation of mitochondrial fission (GO:0090141)2.52936115
107de novo protein folding (GO:0006458)2.52290814
108body morphogenesis (GO:0010171)2.51847645
109positive regulation of protein homodimerization activity (GO:0090073)2.51439472
110axon extension involved in axon guidance (GO:0048846)2.50257755
111neuron projection extension involved in neuron projection guidance (GO:1902284)2.50257755
112pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.49388201
113regulation of RNA export from nucleus (GO:0046831)2.48532089
114DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.48186338
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47695246
116vocalization behavior (GO:0071625)2.47494159
117establishment of nucleus localization (GO:0040023)2.46440264
118protein localization to mitochondrion (GO:0070585)2.44565757
119phagosome maturation (GO:0090382)2.44314499
120regulation of neuronal synaptic plasticity (GO:0048168)2.44291268
121ectodermal placode formation (GO:0060788)2.44269191
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.44006525
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43599406
124catecholamine transport (GO:0051937)2.42272258
125central nervous system projection neuron axonogenesis (GO:0021952)2.41079398
126positive regulation of cAMP-mediated signaling (GO:0043950)2.39891174
127presynaptic membrane assembly (GO:0097105)2.39831981
128inositol phosphate catabolic process (GO:0071545)2.39012315
129CTP biosynthetic process (GO:0006241)2.38482482
130CTP metabolic process (GO:0046036)2.38482482
131dendritic spine morphogenesis (GO:0060997)2.38149402
132positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.38115236
133positive regulation of cell cycle G2/M phase transition (GO:1902751)2.38115236
134RNA localization (GO:0006403)2.37754686
135positive regulation of cell cycle arrest (GO:0071158)2.37613459
136negative regulation of calcium ion transport into cytosol (GO:0010523)2.37267044
137embryonic foregut morphogenesis (GO:0048617)2.36460217
138COPI coating of Golgi vesicle (GO:0048205)2.35758667
139Golgi transport vesicle coating (GO:0048200)2.35758667
140signal peptide processing (GO:0006465)2.34660325
141stress granule assembly (GO:0034063)2.33913737
142neuromuscular process controlling balance (GO:0050885)2.32887470
143neuron projection extension (GO:1990138)2.32051497
1442-deoxyribonucleotide metabolic process (GO:0009394)2.31965560
145regulation of inositol phosphate biosynthetic process (GO:0010919)2.31513792
146regulation of mitotic spindle checkpoint (GO:1903504)2.31493993
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31493993
148peptidyl-histidine modification (GO:0018202)2.31477153
149mast cell activation (GO:0045576)2.31130293
150asymmetric protein localization (GO:0008105)2.31002048
151regulation of ligase activity (GO:0051340)2.30921680
152pore complex assembly (GO:0046931)2.29419467
153positive regulation of dendritic spine development (GO:0060999)2.29164760
154DNA unwinding involved in DNA replication (GO:0006268)2.26127583
155hippo signaling (GO:0035329)2.24540930
156presynaptic membrane organization (GO:0097090)2.24437230
157sister chromatid segregation (GO:0000819)2.23888108
158regulation of dendritic spine morphogenesis (GO:0061001)2.23796950
159NLS-bearing protein import into nucleus (GO:0006607)2.23760928
160cellular potassium ion homeostasis (GO:0030007)2.22596717
161regulation of glutamate receptor signaling pathway (GO:1900449)2.21877350
162positive regulation of synapse assembly (GO:0051965)2.21407659
163regulation of long-term neuronal synaptic plasticity (GO:0048169)2.20823598
164suckling behavior (GO:0001967)2.20673238
165regulation of nucleobase-containing compound transport (GO:0032239)2.18516647
166glucocorticoid receptor signaling pathway (GO:0042921)2.18254183
167positive regulation of axon extension (GO:0045773)2.18128705
168sodium ion export (GO:0071436)2.17430554
169establishment of mitochondrion localization (GO:0051654)2.17297851
170developmental cell growth (GO:0048588)2.17056537
171regulation of dendrite morphogenesis (GO:0048814)2.16900437
172synaptic vesicle maturation (GO:0016188)2.16689333
173establishment of spindle localization (GO:0051293)2.15783221
174regulation of translational fidelity (GO:0006450)2.15146571
175notochord development (GO:0030903)2.14462554
176innervation (GO:0060384)2.14184070
177cerebellar Purkinje cell layer development (GO:0021680)2.13713579
178heterochromatin organization (GO:0070828)2.13541728
179mitotic sister chromatid segregation (GO:0000070)2.12738340
180negative regulation of DNA repair (GO:0045738)2.12107239
181cytoplasmic mRNA processing body assembly (GO:0033962)2.11957699
182cytoskeleton-dependent cytokinesis (GO:0061640)2.11531423
183L-amino acid import (GO:0043092)2.11143363
184regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.10484542
185exploration behavior (GO:0035640)2.10470135
186neurotransmitter secretion (GO:0007269)2.10085108
187locomotory exploration behavior (GO:0035641)2.08911168
188planar cell polarity pathway involved in neural tube closure (GO:0090179)2.08722327
189establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.07741124
190mitochondrion transport along microtubule (GO:0047497)2.07741124
191synaptic transmission, glutamatergic (GO:0035249)2.07256137
192mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.07133561
193bone trabecula formation (GO:0060346)2.06757593
194dendritic spine organization (GO:0097061)2.06666755
195negative regulation of keratinocyte proliferation (GO:0010839)2.06496688
196mitotic sister chromatid cohesion (GO:0007064)2.06349425
197G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.04411477
198retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.03528822
199glutamate receptor signaling pathway (GO:0007215)2.03391472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.75569019
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39178586
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09363070
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.01747386
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97643124
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.56036625
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33006619
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22087804
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08524190
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97006399
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78283732
12E2F7_22180533_ChIP-Seq_HELA_Human2.77140964
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.63609823
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.51960706
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39644127
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39612182
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38662539
18* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.35732569
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35007850
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24442148
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20398901
22TAF15_26573619_Chip-Seq_HEK293_Human2.15121023
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11854817
24VDR_23849224_ChIP-Seq_CD4+_Human2.11833444
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07180557
26* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06982962
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.06464591
28ELK1_19687146_ChIP-ChIP_HELA_Human2.04108555
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99163636
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99115775
31* IRF8_21731497_ChIP-ChIP_J774_Mouse1.98945566
32* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98416836
33AR_21572438_ChIP-Seq_LNCaP_Human1.95897340
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.93972123
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93213647
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86257043
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84808938
38AR_21909140_ChIP-Seq_LNCAP_Human1.83386856
39* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83089825
40GBX2_23144817_ChIP-Seq_PC3_Human1.80624176
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.79442798
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78730238
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77489852
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77489852
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76271155
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74967647
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.73896972
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73668423
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.72252604
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.68739739
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68331796
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68324992
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.68033205
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.67446140
55VDR_22108803_ChIP-Seq_LS180_Human1.63149264
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61972406
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60678096
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59493276
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59133807
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58815884
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58781145
62* FOXP3_21729870_ChIP-Seq_TREG_Human1.58251589
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.57980776
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55168475
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54383867
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53259007
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.52435007
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.51324777
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49331074
70EZH2_22144423_ChIP-Seq_EOC_Human1.47541480
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47400717
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.45482136
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.45178716
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44342311
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.44228629
76GABP_19822575_ChIP-Seq_HepG2_Human1.42460435
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40665249
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40471155
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40286172
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39965221
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39956946
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39274044
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37486391
84DCP1A_22483619_ChIP-Seq_HELA_Human1.37343267
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.36738555
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36072676
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33529121
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33160445
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.33012416
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32389446
91CLOCK_20551151_ChIP-Seq_293T_Human1.32018286
92* SPI1_23547873_ChIP-Seq_NB4_Human1.30759602
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30709836
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29168789
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28351896
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27506179
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24964218
98* ELK1_22589737_ChIP-Seq_MCF10A_Human1.22679433
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22381182
100TTF2_22483619_ChIP-Seq_HELA_Human1.21689418
101TP53_16413492_ChIP-PET_HCT116_Human1.21229052
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20968840
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19783209
104AHR_22903824_ChIP-Seq_MCF-7_Human1.18572586
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17865066
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17197399
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.17063043
108SOX9_26525672_Chip-Seq_HEART_Mouse1.16758363
109IGF1R_20145208_ChIP-Seq_DFB_Human1.16654479
110* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15927884
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15761797
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15266118
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.14595129
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14507641
115IRF1_19129219_ChIP-ChIP_H3396_Human1.14467311
116TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14039079
117* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13895714
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13767419
119TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13406863
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12613182
121XRN2_22483619_ChIP-Seq_HELA_Human1.12286781
122* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11060807
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10998567
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10908088
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10512052
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10379896
127EWS_26573619_Chip-Seq_HEK293_Human1.10092201
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09633745
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.08387376
130FOXA2_19822575_ChIP-Seq_HepG2_Human1.08334565
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06738903
132* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06534292
133P300_19829295_ChIP-Seq_ESCs_Human1.06045031
134RNF2_27304074_Chip-Seq_NSC_Mouse1.05606499
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05102170
136MYC_18940864_ChIP-ChIP_HL60_Human1.04021837
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03708769
138ESR1_21235772_ChIP-Seq_MCF-7_Human1.03538359
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02989299
140NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02127565
141* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01912742
142KDM2B_26808549_Chip-Seq_K562_Human1.00800628
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.99823782
144POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98182069
145CIITA_25753668_ChIP-Seq_RAJI_Human0.97768730
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.97211099
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97004348
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96747241
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95758268
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.94970504
151POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94823363
152NOTCH1_21737748_ChIP-Seq_TLL_Human0.94723173
153* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93957414
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93199760
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92233004
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92087644
157POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91842079
158* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91586997
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91453547
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91453547
161SCL_19346495_ChIP-Seq_HPC-7_Human0.91404014
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91181286
163POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91125214
164NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90906584
165FUS_26573619_Chip-Seq_HEK293_Human0.90576815
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90179762
167SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89586618
168DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89272778
169CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89093426
170ZNF263_19887448_ChIP-Seq_K562_Human0.88689741
171JUN_21703547_ChIP-Seq_K562_Human0.88638070
172MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88462204
173CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88063651
174* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87976080
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87944266
176PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87757722
177REST_21632747_ChIP-Seq_MESCs_Mouse0.87185777
178EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86890262
179MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86477730
180FLI1_27457419_Chip-Seq_LIVER_Mouse0.85216885
181* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83937912
182GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83703195
183GATA1_22025678_ChIP-Seq_K562_Human0.82543424
184CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82238017
185LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82226162
186TAL1_26923725_Chip-Seq_HPCs_Mouse0.81642269
187* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79167765
188CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78894427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.26779409
2MP0001968_abnormal_touch/_nociception2.98255781
3MP0002736_abnormal_nociception_after2.93131865
4MP0002735_abnormal_chemical_nociception2.92780213
5MP0001529_abnormal_vocalization2.84551195
6MP0004147_increased_porphyrin_level2.72246387
7MP0001905_abnormal_dopamine_level2.69141619
8MP0003890_abnormal_embryonic-extraembry2.33517068
9MP0001986_abnormal_taste_sensitivity2.31695274
10MP0001835_abnormal_antigen_presentation2.29395635
11MP0006276_abnormal_autonomic_nervous2.23555227
12MP0000015_abnormal_ear_pigmentation2.21439920
13MP0009379_abnormal_foot_pigmentation2.14203976
14MP0001188_hyperpigmentation2.06012133
15MP0005671_abnormal_response_to1.99253427
16MP0000566_synostosis1.97309460
17MP0002734_abnormal_mechanical_nocicepti1.95652978
18MP0000537_abnormal_urethra_morphology1.88046121
19MP0004270_analgesia1.84842538
20MP0004859_abnormal_synaptic_plasticity1.84602140
21MP0002148_abnormal_hypersensitivity_rea1.81203211
22MP0003635_abnormal_synaptic_transmissio1.80120067
23MP0002064_seizures1.79847481
24MP0005409_darkened_coat_color1.78403734
25MP0009745_abnormal_behavioral_response1.76210157
26MP0003123_paternal_imprinting1.74844255
27MP0000569_abnormal_digit_pigmentation1.73037484
28MP0001970_abnormal_pain_threshold1.72360149
29MP0002272_abnormal_nervous_system1.72205325
30MP0002733_abnormal_thermal_nociception1.71316976
31MP0009046_muscle_twitch1.71244074
32MP0001984_abnormal_olfaction1.69292700
33MP0009785_altered_susceptibility_to1.63920669
34MP0003705_abnormal_hypodermis_morpholog1.63530228
35MP0003385_abnormal_body_wall1.63116598
36MP0004272_abnormal_basement_membrane1.62563598
37MP0003937_abnormal_limbs/digits/tail_de1.59126735
38MP0003942_abnormal_urinary_system1.58571168
39MP0005623_abnormal_meninges_morphology1.56256607
40MP0001299_abnormal_eye_distance/1.52796982
41MP0002572_abnormal_emotion/affect_behav1.51911868
42MP0005075_abnormal_melanosome_morpholog1.51711445
43MP0006292_abnormal_olfactory_placode1.49618803
44MP0004142_abnormal_muscle_tone1.48958849
45MP0002089_abnormal_postnatal_growth/wei1.48820278
46MP0000534_abnormal_ureter_morphology1.48587668
47MP0009333_abnormal_splenocyte_physiolog1.48390867
48MP0002063_abnormal_learning/memory/cond1.48121204
49MP0003861_abnormal_nervous_system1.47925682
50MP0000955_abnormal_spinal_cord1.47122707
51MP0002938_white_spotting1.45104060
52MP0003122_maternal_imprinting1.44068359
53MP0001346_abnormal_lacrimal_gland1.41614385
54MP0005257_abnormal_intraocular_pressure1.41264473
55MP0003724_increased_susceptibility_to1.39200955
56MP0003787_abnormal_imprinting1.37504099
57MP0000372_irregular_coat_pigmentation1.34753610
58MP0005646_abnormal_pituitary_gland1.32429190
59MP0000579_abnormal_nail_morphology1.31123197
60MP0003329_amyloid_beta_deposits1.31024961
61MP0002084_abnormal_developmental_patter1.28741287
62MP0002396_abnormal_hematopoietic_system1.28439324
63MP0003283_abnormal_digestive_organ1.27559850
64MP0002067_abnormal_sensory_capabilities1.27100226
65MP0005174_abnormal_tail_pigmentation1.27099241
66MP0002876_abnormal_thyroid_physiology1.26880454
67MP0002697_abnormal_eye_size1.26863913
68MP0010030_abnormal_orbit_morphology1.24985253
69MP0005187_abnormal_penis_morphology1.24976795
70MP0002095_abnormal_skin_pigmentation1.24761024
71MP0005000_abnormal_immune_tolerance1.24668675
72MP0003315_abnormal_perineum_morphology1.23879214
73MP0003935_abnormal_craniofacial_develop1.23710634
74MP0002152_abnormal_brain_morphology1.22841228
75MP0003941_abnormal_skin_development1.21897814
76MP0010386_abnormal_urinary_bladder1.20167725
77MP0002420_abnormal_adaptive_immunity1.20039341
78MP0001486_abnormal_startle_reflex1.20033462
79MP0000428_abnormal_craniofacial_morphol1.19908396
80MP0000681_abnormal_thyroid_gland1.19647738
81MP0001501_abnormal_sleep_pattern1.19158502
82MP0001819_abnormal_immune_cell1.18803716
83MP0005645_abnormal_hypothalamus_physiol1.18736334
84MP0002638_abnormal_pupillary_reflex1.17023409
85MP0003183_abnormal_peptide_metabolism1.17010096
86MP0008260_abnormal_autophagy1.14836102
87MP0009697_abnormal_copulation1.14537495
88MP0002723_abnormal_immune_serum1.13302555
89MP0009780_abnormal_chondrocyte_physiolo1.11381251
90MP0008058_abnormal_DNA_repair1.11351553
91MP0005076_abnormal_cell_differentiation1.11064541
92MP0003755_abnormal_palate_morphology1.10368855
93MP0003950_abnormal_plasma_membrane1.09916988
94MP0009053_abnormal_anal_canal1.08520376
95MP0008438_abnormal_cutaneous_collagen1.07111323
96MP0005423_abnormal_somatic_nervous1.07081626
97MP0002398_abnormal_bone_marrow1.06995863
98MP0002419_abnormal_innate_immunity1.06662755
99MP0002751_abnormal_autonomic_nervous1.05939463
100MP0002452_abnormal_antigen_presenting1.05160498
101MP0005025_abnormal_response_to1.04626477
102MP0002085_abnormal_embryonic_tissue1.04245775
103MP0002184_abnormal_innervation1.03854951
104MP0001800_abnormal_humoral_immune1.03227844
105MP0003119_abnormal_digestive_system1.03048016
106MP0004924_abnormal_behavior1.02174285
107MP0005386_behavior/neurological_phenoty1.02174285
108MP0009672_abnormal_birth_weight1.01519607
109MP0010368_abnormal_lymphatic_system1.01407178
110MP0002081_perinatal_lethality1.00804493
111MP0001177_atelectasis1.00640434
112MP0003656_abnormal_erythrocyte_physiolo1.00052300
113MP0005171_absent_coat_pigmentation0.99970235
114MP0000462_abnormal_digestive_system0.99853698
115MP0003938_abnormal_ear_development0.99837285
116MP0010352_gastrointestinal_tract_polyps0.98843901
117MP0002233_abnormal_nose_morphology0.98779519
118MP0003115_abnormal_respiratory_system0.98480202
119MP0001672_abnormal_embryogenesis/_devel0.98404272
120MP0005380_embryogenesis_phenotype0.98404272
121MP0000716_abnormal_immune_system0.97973252
122MP0001730_embryonic_growth_arrest0.97485887
123MP0008057_abnormal_DNA_replication0.97433587
124MP0006054_spinal_hemorrhage0.97406700
125MP0004133_heterotaxia0.96835689
126MP0003136_yellow_coat_color0.96743876
127MP0003186_abnormal_redox_activity0.96535789
128MP0003632_abnormal_nervous_system0.96515309
129MP0002092_abnormal_eye_morphology0.96361047
130MP0002557_abnormal_social/conspecific_i0.95037106
131MP0001293_anophthalmia0.94766865
132MP0000689_abnormal_spleen_morphology0.93586522
133MP0000920_abnormal_myelination0.93458821
134MP0008877_abnormal_DNA_methylation0.93347243
135MP0005394_taste/olfaction_phenotype0.93060074
136MP0005499_abnormal_olfactory_system0.93060074
137MP0000762_abnormal_tongue_morphology0.92329699
138MP0003111_abnormal_nucleus_morphology0.92302600
139MP0005464_abnormal_platelet_physiology0.91667962
140MP0002116_abnormal_craniofacial_bone0.90973083
141MP0003634_abnormal_glial_cell0.90707872
142MP0002877_abnormal_melanocyte_morpholog0.90695470
143MP0008789_abnormal_olfactory_epithelium0.89811665
144MP0002088_abnormal_embryonic_growth/wei0.89738619
145MP0008932_abnormal_embryonic_tissue0.89668917
146MP0001440_abnormal_grooming_behavior0.89487030
147MP0003984_embryonic_growth_retardation0.88863075
148MP0000778_abnormal_nervous_system0.88458132
149MP0005387_immune_system_phenotype0.86734835
150MP0001790_abnormal_immune_system0.86734835
151MP0010234_abnormal_vibrissa_follicle0.86631372
152MP0001697_abnormal_embryo_size0.85615824
153MP0001849_ear_inflammation0.85465247
154MP0001286_abnormal_eye_development0.85422775
155MP0004811_abnormal_neuron_physiology0.85312647
156MP0002722_abnormal_immune_system0.85225276
157MP0000465_gastrointestinal_hemorrhage0.85081682
158MP0006035_abnormal_mitochondrial_morpho0.85076541
159MP0004197_abnormal_fetal_growth/weight/0.84999647
160MP0002429_abnormal_blood_cell0.83757244
161MP0004885_abnormal_endolymph0.83642031
162MP0008569_lethality_at_weaning0.83247486
163MP0003693_abnormal_embryo_hatching0.82430358
164MP0005408_hypopigmentation0.81495286
165MP0009703_decreased_birth_body0.81312308
166MP0000432_abnormal_head_morphology0.81106351
167MP0006082_CNS_inflammation0.78525447
168MP0001664_abnormal_digestion0.77617177
169MP0001963_abnormal_hearing_physiology0.77310898
170MP0002229_neurodegeneration0.76257312
171MP0002822_catalepsy0.76048677
172MP0002882_abnormal_neuron_morphology0.72221385
173MP0003121_genomic_imprinting0.71826282

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.23360557
2Acute necrotizing encephalopathy (HP:0006965)4.31032849
3Hepatocellular necrosis (HP:0001404)4.30136611
4Mitochondrial inheritance (HP:0001427)4.23661142
5Abnormal mitochondria in muscle tissue (HP:0008316)3.84149437
6Increased CSF lactate (HP:0002490)3.70530670
7Increased hepatocellular lipid droplets (HP:0006565)3.58090695
8Progressive macrocephaly (HP:0004481)3.49428142
9Abnormal hair whorl (HP:0010721)3.36511416
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.31604165
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.31604165
12Hepatic necrosis (HP:0002605)3.29428873
13Abnormality of glycolysis (HP:0004366)3.27590462
14Increased serum pyruvate (HP:0003542)3.27590462
15Renal Fanconi syndrome (HP:0001994)3.17267736
16Acute encephalopathy (HP:0006846)3.14619880
17Type I transferrin isoform profile (HP:0003642)3.04283433
18Lipid accumulation in hepatocytes (HP:0006561)3.00732386
19Recurrent abscess formation (HP:0002722)3.00544655
20Renal duplication (HP:0000075)2.95745060
213-Methylglutaconic aciduria (HP:0003535)2.88749760
22Hyperacusis (HP:0010780)2.82597561
23Elevated erythrocyte sedimentation rate (HP:0003565)2.80429906
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77062297
25Increased serum lactate (HP:0002151)2.74827296
26Insomnia (HP:0100785)2.70490623
27Exertional dyspnea (HP:0002875)2.69645299
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68815766
29Focal motor seizures (HP:0011153)2.66915145
30Asymmetry of the thorax (HP:0001555)2.65109677
31Renovascular hypertension (HP:0100817)2.63408399
32Respiratory difficulties (HP:0002880)2.62726334
33Aplastic anemia (HP:0001915)2.62097435
34Lactic acidosis (HP:0003128)2.60438944
35Overriding aorta (HP:0002623)2.55809927
36Microvesicular hepatic steatosis (HP:0001414)2.51837334
37Gonadotropin excess (HP:0000837)2.49753105
38Neuroendocrine neoplasm (HP:0100634)2.48151840
39Myokymia (HP:0002411)2.43425094
40Recurrent bacterial skin infections (HP:0005406)2.43388386
41Hepatoblastoma (HP:0002884)2.41406053
42Birth length less than 3rd percentile (HP:0003561)2.39003840
43Petechiae (HP:0000967)2.33500854
44Elfin facies (HP:0004428)2.32471737
45Increased nuchal translucency (HP:0010880)2.32042039
46Limb dystonia (HP:0002451)2.31992396
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31163142
48Abnormal protein N-linked glycosylation (HP:0012347)2.31163142
49Abnormal protein glycosylation (HP:0012346)2.31163142
50Abnormal glycosylation (HP:0012345)2.31163142
51Exercise intolerance (HP:0003546)2.28895530
52Cerebral hypomyelination (HP:0006808)2.28578556
53Pancreatic fibrosis (HP:0100732)2.26247267
54Patchy hypopigmentation of hair (HP:0011365)2.24644784
55Autoamputation (HP:0001218)2.24418515
56Heterochromia iridis (HP:0001100)2.21804579
57Increased intramyocellular lipid droplets (HP:0012240)2.21613265
58Optic disc pallor (HP:0000543)2.21322467
59Epileptic encephalopathy (HP:0200134)2.21270435
60Pheochromocytoma (HP:0002666)2.19921541
61Heterotopia (HP:0002282)2.17838261
62True hermaphroditism (HP:0010459)2.16082645
63Midline defect of the nose (HP:0004122)2.15771916
64Respiratory failure (HP:0002878)2.14305738
65Reduced antithrombin III activity (HP:0001976)2.13455903
66Atonic seizures (HP:0010819)2.12341898
67IgM deficiency (HP:0002850)2.11390537
68Irregular epiphyses (HP:0010582)2.10848750
69Medial flaring of the eyebrow (HP:0010747)2.10558480
70Trigonocephaly (HP:0000243)2.08206778
71Abnormal autonomic nervous system physiology (HP:0012332)2.07716765
72Drooling (HP:0002307)2.06354456
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.04724618
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04724618
75White forelock (HP:0002211)2.04582027
76Type 2 muscle fiber atrophy (HP:0003554)2.01556671
77Protrusio acetabuli (HP:0003179)2.01114030
78High anterior hairline (HP:0009890)2.00731036
79Nephrogenic diabetes insipidus (HP:0009806)2.00577396
80Leukodystrophy (HP:0002415)1.99306899
81Neurofibrillary tangles (HP:0002185)1.99185088
82Arterial tortuosity (HP:0005116)1.98946883
83Arnold-Chiari malformation (HP:0002308)1.97844437
84Cortical dysplasia (HP:0002539)1.96541806
85Small epiphyses (HP:0010585)1.96019613
86Papillary thyroid carcinoma (HP:0002895)1.95829790
87Cutaneous finger syndactyly (HP:0010554)1.94412767
88Abnormal number of erythroid precursors (HP:0012131)1.94173214
89Bladder diverticulum (HP:0000015)1.93750611
90Split foot (HP:0001839)1.93551975
91Focal seizures (HP:0007359)1.92373134
92Gait imbalance (HP:0002141)1.92046237
93Panhypogammaglobulinemia (HP:0003139)1.91720674
94Megalencephaly (HP:0001355)1.90002094
95Flat cornea (HP:0007720)1.89344160
96Hypokinesia (HP:0002375)1.86260690
97Poor suck (HP:0002033)1.85626537
98Megalocornea (HP:0000485)1.84665473
99Emotional lability (HP:0000712)1.84453063
100Bowel diverticulosis (HP:0005222)1.84165790
101Polyphagia (HP:0002591)1.84040783
102Aplasia involving bones of the extremities (HP:0009825)1.83996439
103Aplasia involving bones of the upper limbs (HP:0009823)1.83996439
104Aplasia of the phalanges of the hand (HP:0009802)1.83996439
105Agammaglobulinemia (HP:0004432)1.83681548
106Congenital primary aphakia (HP:0007707)1.83115472
107Optic nerve coloboma (HP:0000588)1.82541078
108Abnormality of cells of the erythroid lineage (HP:0012130)1.81792351
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81061244
110Dysautonomia (HP:0002459)1.79475676
111Bronchomalacia (HP:0002780)1.78703513
112Overgrowth (HP:0001548)1.78659810
113IgG deficiency (HP:0004315)1.78309090
114Abnormality of the heme biosynthetic pathway (HP:0010472)1.77841294
115Neonatal short-limb short stature (HP:0008921)1.77646471
116Termporal pattern (HP:0011008)1.77489024
117Insidious onset (HP:0003587)1.77489024
118Shallow orbits (HP:0000586)1.77401272
119Abnormal pupillary function (HP:0007686)1.77370673
120Limited elbow extension (HP:0001377)1.76456488
121Cerebral inclusion bodies (HP:0100314)1.75813909
122Excessive salivation (HP:0003781)1.75658799
123Delusions (HP:0000746)1.75120975
124Overlapping toe (HP:0001845)1.74939093
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74919299
126Vertebral arch anomaly (HP:0008438)1.74060703
127Abnormality of renal resorption (HP:0011038)1.73698912
128Parakeratosis (HP:0001036)1.72820988
129Agnosia (HP:0010524)1.72412089
130Febrile seizures (HP:0002373)1.72052364
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70704204
132Abnormality of alanine metabolism (HP:0010916)1.70376373
133Hyperalaninemia (HP:0003348)1.70376373
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70376373
135Short 4th metacarpal (HP:0010044)1.70218655
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70218655
137Skull defect (HP:0001362)1.70180616
138Myositis (HP:0100614)1.69673865
139Vascular tortuosity (HP:0004948)1.69394596
140Generalized hypotonia (HP:0001290)1.69359900
141B lymphocytopenia (HP:0010976)1.68936895
142Abnormality of B cell number (HP:0010975)1.68936895
143Wide anterior fontanel (HP:0000260)1.68677022
144Neutropenia (HP:0001875)1.67815373
145Sacral dimple (HP:0000960)1.66221905
146Methylmalonic acidemia (HP:0002912)1.66107973
147Increased muscle lipid content (HP:0009058)1.65975637
148Methylmalonic aciduria (HP:0012120)1.64878730
149Inability to walk (HP:0002540)1.64555402
150Pointed chin (HP:0000307)1.64465238
151Exotropia (HP:0000577)1.64226166
152Cutaneous syndactyly (HP:0012725)1.63955900
153Smooth philtrum (HP:0000319)1.63718352
154Generalized tonic-clonic seizures (HP:0002069)1.63622936
155Omphalocele (HP:0001539)1.62930639
156Gastroesophageal reflux (HP:0002020)1.62710379
157Broad palm (HP:0001169)1.62394712
158Premature rupture of membranes (HP:0001788)1.58902359
159Alacrima (HP:0000522)1.58857311
160Open mouth (HP:0000194)1.57714956
161Broad thumb (HP:0011304)1.57455779
162Urinary urgency (HP:0000012)1.56600132
163Obsessive-compulsive behavior (HP:0000722)1.56414198
164Hypopigmentation of the fundus (HP:0007894)1.53641677
165Action tremor (HP:0002345)1.52451692
166Prominent forehead (HP:0011220)1.51042423
167Myelomeningocele (HP:0002475)1.49009685
168Hypoplasia of the brainstem (HP:0002365)1.48976983
169Aplasia/Hypoplasia of the brainstem (HP:0007362)1.48976983
170Ankyloglossia (HP:0010296)1.48899434
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.46960254
172Spastic tetraparesis (HP:0001285)1.46556118
173Buphthalmos (HP:0000557)1.46122215
174Neoplasm of the peripheral nervous system (HP:0100007)1.45225524
175Abnormality of the diencephalon (HP:0010662)1.45152881
176Flat acetabular roof (HP:0003180)1.45108823
177Large earlobe (HP:0009748)1.44785463
178Patellar dislocation (HP:0002999)1.44725007
179Absence seizures (HP:0002121)1.44464703
180Hammertoe (HP:0001765)1.43984720
181Supranuclear gaze palsy (HP:0000605)1.42382379
182Diastasis recti (HP:0001540)1.42045052
183Macroorchidism (HP:0000053)1.41669530
184Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.41629812
185Mild short stature (HP:0003502)1.40936052
186Shawl scrotum (HP:0000049)1.40502753
187Capillary hemangiomas (HP:0005306)1.39915749
188Bilateral microphthalmos (HP:0007633)1.39615865
189Radioulnar synostosis (HP:0002974)1.39597167
190Impaired pain sensation (HP:0007328)1.39307695
191Abnormality of pain sensation (HP:0010832)1.39307695
192Abnormal ossification of hand bones (HP:0005921)1.38263577
193Abnormality of the 4th metacarpal (HP:0010012)1.38193003
194Missing ribs (HP:0000921)1.38150533
195Coronal craniosynostosis (HP:0004440)1.38079533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.30769668
2STK163.84984587
3NTRK22.87741106
4CASK2.79557748
5LATS22.64525486
6EEF2K2.56368787
7TNIK2.50515763
8CDK192.46471139
9PNCK2.46391622
10BUB12.43966847
11GRK72.40950177
12CDK122.39555464
13ADRBK22.24815671
14ICK2.20512797
15SIK32.16622965
16VRK12.13235905
17TRIB32.12208279
18MAP2K72.09233139
19PDGFRA2.07125152
20TYRO32.04377759
21NME11.99714812
22MST41.99476967
23TESK21.90322654
24LATS11.88260362
25NEK11.82033174
26MAP3K91.75744462
27RIPK41.71158750
28ARAF1.67162364
29CCNB11.55534457
30AKT31.54451791
31MUSK1.53694967
32FGFR21.52814615
33CAMK1G1.52443103
34SIK21.51718808
35BMPR1B1.49691935
36TSSK61.44062347
37FGFR41.42210194
38NEK21.41315999
39PIM21.37887982
40EIF2AK31.37275908
41MAPK131.36876141
42BRD41.35517393
43MYLK1.34660307
44LIMK11.33779607
45PBK1.32618740
46KSR11.31851260
47EIF2AK11.31338861
48MKNK11.26748012
49MINK11.26596905
50PRPF4B1.26073784
51PRKD31.25239614
52GRK51.23232004
53PLK21.21451323
54TEC1.19517233
55TXK1.18040273
56IRAK41.17864750
57MAP3K101.17263346
58SYK1.14324908
59MAPKAPK51.13588188
60DAPK11.10280267
61KIT1.09116126
62OXSR11.09104981
63MET1.07881267
64CAMK1D1.06276167
65PAK61.05010286
66RET1.04478361
67SCYL21.01523312
68YES11.00742320
69PINK11.00051010
70FES0.98259015
71MAP4K10.97766616
72BMPR20.97441291
73WNK10.96904497
74WNK40.96800330
75MATK0.94625095
76MTOR0.94489665
77STK38L0.90755074
78TTK0.90308851
79PKN20.90222737
80KSR20.89926431
81BLK0.88346091
82SRPK10.87059068
83FGFR30.86872640
84NTRK30.86182539
85BCR0.81466158
86WNK30.80881400
87PTK20.80838017
88ERBB30.80506779
89IKBKE0.79171718
90TESK10.78127922
91DYRK20.77806152
92WEE10.75730191
93RIPK10.75348273
94TGFBR20.74792485
95RPS6KB10.74734179
96ADRBK10.74675899
97CDK150.74532767
98EPHB20.74037875
99MKNK20.72361189
100FGFR10.71619983
101MAP3K40.71371964
102CLK10.70315054
103STK30.70020320
104PAK20.69568198
105CSNK1G20.69156660
106TBK10.68512746
107CSNK1E0.67959900
108CDK11A0.67030168
109CSNK1A1L0.66719028
110LYN0.66203899
111NUAK10.66042410
112PIK3CA0.65404251
113MARK10.64819205
114TLK10.64146742
115EIF2AK20.64100904
116PDGFRB0.64071400
117ALK0.63988048
118SMG10.63851807
119UHMK10.63755037
120NME20.63668043
121SGK30.62575641
122CSNK1G30.61887750
123PLK30.61819333
124CDK80.61152420
125CAMKK20.60294598
126BRAF0.59092607
127CAMKK10.56871080
128NEK60.56759535
129DYRK1A0.55699066
130MELK0.55579502
131CSNK1D0.53665420
132TGFBR10.53344123
133BRSK10.53035134
134BTK0.52957027
135ERBB40.52242673
136SGK2230.52124031
137SGK4940.52124031
138CDK70.51971897
139PRKCG0.51167699
140LCK0.50750076
141NTRK10.50233657
142MAP3K110.50156135
143MAPK100.50025985
144EPHA40.49996891
145ROCK20.49145623
146CDK10.48525545
147ATM0.48436373
148CAMK2A0.47276379
149CDK180.46621490
150MAP3K140.46556468
151TIE10.46480512
152CHEK20.46064393
153CSF1R0.45436724
154RAF10.45237829
155CDK140.45003607
156CDK30.44946123
157CSNK1G10.44872895
158KDR0.44210608
159CDK50.43871649
160STK380.43330408
161PAK30.43250975
162STK390.42830184
163PRKCD0.42725032
164PRKCE0.41568126
165CAMK2B0.40707977
166ZAK0.40044517
167SGK20.38673259
168ZAP700.38086725

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.52821577
2Oxidative phosphorylation_Homo sapiens_hsa001903.47393546
3Parkinsons disease_Homo sapiens_hsa050123.07806023
4Ribosome_Homo sapiens_hsa030102.73103310
5RNA polymerase_Homo sapiens_hsa030202.66912503
6Protein export_Homo sapiens_hsa030602.56227848
7Alzheimers disease_Homo sapiens_hsa050102.17450829
8Collecting duct acid secretion_Homo sapiens_hsa049662.15647038
9Huntingtons disease_Homo sapiens_hsa050162.08613565
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.03566137
11Synaptic vesicle cycle_Homo sapiens_hsa047212.01012883
12Hippo signaling pathway_Homo sapiens_hsa043901.83178994
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78289605
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77153434
15Base excision repair_Homo sapiens_hsa034101.75130183
16Vibrio cholerae infection_Homo sapiens_hsa051101.71256159
17DNA replication_Homo sapiens_hsa030301.69397403
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58660251
19Primary immunodeficiency_Homo sapiens_hsa053401.57224443
20Axon guidance_Homo sapiens_hsa043601.56230330
21Pyrimidine metabolism_Homo sapiens_hsa002401.54477990
22Nicotine addiction_Homo sapiens_hsa050331.53290764
23Nucleotide excision repair_Homo sapiens_hsa034201.51855799
24Endometrial cancer_Homo sapiens_hsa052131.50374680
25Spliceosome_Homo sapiens_hsa030401.49591180
26Estrogen signaling pathway_Homo sapiens_hsa049151.49024920
27Mismatch repair_Homo sapiens_hsa034301.48686524
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46937145
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40570107
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37654736
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37653091
32Glioma_Homo sapiens_hsa052141.36266392
33ErbB signaling pathway_Homo sapiens_hsa040121.35706827
34Non-homologous end-joining_Homo sapiens_hsa034501.33764667
35Basal cell carcinoma_Homo sapiens_hsa052171.32178780
36mRNA surveillance pathway_Homo sapiens_hsa030151.31717869
37Thyroid hormone synthesis_Homo sapiens_hsa049181.30035368
38Melanogenesis_Homo sapiens_hsa049161.28366033
39MicroRNAs in cancer_Homo sapiens_hsa052061.27875212
40Hedgehog signaling pathway_Homo sapiens_hsa043401.27354892
41Adherens junction_Homo sapiens_hsa045201.27305355
42Homologous recombination_Homo sapiens_hsa034401.25861176
43Vitamin B6 metabolism_Homo sapiens_hsa007501.25355635
44Rheumatoid arthritis_Homo sapiens_hsa053231.24179730
45Gap junction_Homo sapiens_hsa045401.23895778
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23267999
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22533749
48Purine metabolism_Homo sapiens_hsa002301.22217087
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19098538
50Serotonergic synapse_Homo sapiens_hsa047261.19095448
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17221862
52ECM-receptor interaction_Homo sapiens_hsa045121.17142511
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15987437
54Wnt signaling pathway_Homo sapiens_hsa043101.15974527
55Phagosome_Homo sapiens_hsa041451.15339747
56Thyroid cancer_Homo sapiens_hsa052161.14188772
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14093174
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12587554
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10908158
60Chronic myeloid leukemia_Homo sapiens_hsa052201.10071506
61Insulin secretion_Homo sapiens_hsa049111.08999685
62Morphine addiction_Homo sapiens_hsa050321.08992416
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.08511697
64Basal transcription factors_Homo sapiens_hsa030221.07794186
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07520055
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06336306
67Neurotrophin signaling pathway_Homo sapiens_hsa047221.04689012
68Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04606241
69TGF-beta signaling pathway_Homo sapiens_hsa043501.03843109
70Colorectal cancer_Homo sapiens_hsa052101.01907050
71Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01372750
72Proteoglycans in cancer_Homo sapiens_hsa052050.99819332
73Olfactory transduction_Homo sapiens_hsa047400.98672268
74GnRH signaling pathway_Homo sapiens_hsa049120.96029108
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95017749
76RNA degradation_Homo sapiens_hsa030180.94419414
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94064829
78GABAergic synapse_Homo sapiens_hsa047270.93379572
79Lysine degradation_Homo sapiens_hsa003100.93248262
80Non-small cell lung cancer_Homo sapiens_hsa052230.92832224
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92676896
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91908065
83Inositol phosphate metabolism_Homo sapiens_hsa005620.91374392
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91048916
85Renal cell carcinoma_Homo sapiens_hsa052110.90892291
86Epstein-Barr virus infection_Homo sapiens_hsa051690.90487310
87mTOR signaling pathway_Homo sapiens_hsa041500.90468347
88Gastric acid secretion_Homo sapiens_hsa049710.90464519
89Regulation of autophagy_Homo sapiens_hsa041400.89160999
90Focal adhesion_Homo sapiens_hsa045100.88902784
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88115844
92Circadian entrainment_Homo sapiens_hsa047130.88007431
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87751478
94Hematopoietic cell lineage_Homo sapiens_hsa046400.87250144
95Dopaminergic synapse_Homo sapiens_hsa047280.86559990
96Tight junction_Homo sapiens_hsa045300.86460715
97Sphingolipid metabolism_Homo sapiens_hsa006000.85077024
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84998518
99Bladder cancer_Homo sapiens_hsa052190.84589475
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83608852
101Prostate cancer_Homo sapiens_hsa052150.83477413
102Taste transduction_Homo sapiens_hsa047420.82577428
103N-Glycan biosynthesis_Homo sapiens_hsa005100.81966687
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79643604
105Amphetamine addiction_Homo sapiens_hsa050310.77840526
106Prion diseases_Homo sapiens_hsa050200.77759201
107Oxytocin signaling pathway_Homo sapiens_hsa049210.77375057
108Selenocompound metabolism_Homo sapiens_hsa004500.77138596
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75602003
110Small cell lung cancer_Homo sapiens_hsa052220.74752679
111Glutamatergic synapse_Homo sapiens_hsa047240.74624356
112Melanoma_Homo sapiens_hsa052180.74362413
113Choline metabolism in cancer_Homo sapiens_hsa052310.74297858
114VEGF signaling pathway_Homo sapiens_hsa043700.73301668
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72521629
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72348625
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.71276112
118Rap1 signaling pathway_Homo sapiens_hsa040150.71037533
119Dorso-ventral axis formation_Homo sapiens_hsa043200.70742610
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70237417
121Pancreatic cancer_Homo sapiens_hsa052120.68377216
122Cardiac muscle contraction_Homo sapiens_hsa042600.66750190
123AMPK signaling pathway_Homo sapiens_hsa041520.66265369
124Shigellosis_Homo sapiens_hsa051310.66242291
125Fatty acid elongation_Homo sapiens_hsa000620.65983919
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65311815
127Prolactin signaling pathway_Homo sapiens_hsa049170.65309122
128Calcium signaling pathway_Homo sapiens_hsa040200.64668920
129Other glycan degradation_Homo sapiens_hsa005110.64356719
130* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63984462
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63672764
132Ether lipid metabolism_Homo sapiens_hsa005650.63626612
133cAMP signaling pathway_Homo sapiens_hsa040240.63178754
134Allograft rejection_Homo sapiens_hsa053300.63096032
135Phototransduction_Homo sapiens_hsa047440.63044959
136Glucagon signaling pathway_Homo sapiens_hsa049220.60108408
137Autoimmune thyroid disease_Homo sapiens_hsa053200.59139939
138Long-term potentiation_Homo sapiens_hsa047200.59040223
139Pathways in cancer_Homo sapiens_hsa052000.58527303
140Fatty acid biosynthesis_Homo sapiens_hsa000610.57810705
141Insulin signaling pathway_Homo sapiens_hsa049100.57809235
142Antigen processing and presentation_Homo sapiens_hsa046120.56835021
143Protein digestion and absorption_Homo sapiens_hsa049740.56755318
144Pertussis_Homo sapiens_hsa051330.54644592
145Lysosome_Homo sapiens_hsa041420.53701716
146Asthma_Homo sapiens_hsa053100.53662204
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52646498
148Type I diabetes mellitus_Homo sapiens_hsa049400.52314066
149Cholinergic synapse_Homo sapiens_hsa047250.51698548
150Arachidonic acid metabolism_Homo sapiens_hsa005900.51606421
151Tuberculosis_Homo sapiens_hsa051520.50802331
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49864282
153Measles_Homo sapiens_hsa051620.48979664
154Salivary secretion_Homo sapiens_hsa049700.48848344
155Salmonella infection_Homo sapiens_hsa051320.48649673
156RNA transport_Homo sapiens_hsa030130.48219369
157Cocaine addiction_Homo sapiens_hsa050300.47882250
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47299312
159Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47040883
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46896795
161Long-term depression_Homo sapiens_hsa047300.46483321
162Oocyte meiosis_Homo sapiens_hsa041140.46029434
163Graft-versus-host disease_Homo sapiens_hsa053320.45933745
164Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41701940
165Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41282476
166Intestinal immune network for IgA production_Homo sapiens_hsa046720.41158467
167Fanconi anemia pathway_Homo sapiens_hsa034600.40344698
168Cell cycle_Homo sapiens_hsa041100.38371347
169Leishmaniasis_Homo sapiens_hsa051400.37747042
170Legionellosis_Homo sapiens_hsa051340.36159907
171Sphingolipid signaling pathway_Homo sapiens_hsa040710.36113906
172Steroid biosynthesis_Homo sapiens_hsa001000.35830427
173Alcoholism_Homo sapiens_hsa050340.35172989
174Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35145944
175African trypanosomiasis_Homo sapiens_hsa051430.34674828
176Metabolic pathways_Homo sapiens_hsa011000.34198759
177Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33840466

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