DCUN1D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)5.15413125
2cell wall macromolecule metabolic process (GO:0044036)5.15413125
3DNA double-strand break processing (GO:0000729)4.95215420
4definitive hemopoiesis (GO:0060216)4.42551097
5fusion of sperm to egg plasma membrane (GO:0007342)4.27269970
6negative regulation of DNA-dependent DNA replication (GO:2000104)4.26258069
7multicellular organism reproduction (GO:0032504)4.23260346
8platelet dense granule organization (GO:0060155)4.12261238
9ribosomal small subunit assembly (GO:0000028)4.08547341
10sperm-egg recognition (GO:0035036)3.82143615
11lymphoid progenitor cell differentiation (GO:0002320)3.75872259
12response to pheromone (GO:0019236)3.71986005
13binding of sperm to zona pellucida (GO:0007339)3.61192985
14somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.58257989
15isotype switching (GO:0045190)3.58257989
16somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.58257989
17sperm motility (GO:0030317)3.53569236
18CENP-A containing nucleosome assembly (GO:0034080)3.52802223
19reproduction (GO:0000003)3.51848784
20cullin deneddylation (GO:0010388)3.49255704
21regulation of DNA endoreduplication (GO:0032875)3.49224560
22cell-cell recognition (GO:0009988)3.47657651
23protein prenylation (GO:0018342)3.46195651
24prenylation (GO:0097354)3.46195651
25mitotic sister chromatid cohesion (GO:0007064)3.45084782
26lactate metabolic process (GO:0006089)3.40830216
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40252283
28DNA deamination (GO:0045006)3.39504336
29histone mRNA catabolic process (GO:0071044)3.38178898
30regulation of centriole replication (GO:0046599)3.36795023
31microtubule depolymerization (GO:0007019)3.34745357
32protein neddylation (GO:0045116)3.27727925
33chromatin remodeling at centromere (GO:0031055)3.25924974
34megakaryocyte development (GO:0035855)3.25773459
35positive regulation of granulocyte differentiation (GO:0030854)3.23940936
36protein K11-linked deubiquitination (GO:0035871)3.23264494
37plasma membrane fusion (GO:0045026)3.22581686
38histone exchange (GO:0043486)3.21330909
39mitotic G2/M transition checkpoint (GO:0044818)3.20281233
40monoubiquitinated protein deubiquitination (GO:0035520)3.19985648
41regulation of mitotic spindle checkpoint (GO:1903504)3.19750909
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19750909
43protein deneddylation (GO:0000338)3.17152635
44synapsis (GO:0007129)3.16845738
45axonemal dynein complex assembly (GO:0070286)3.15826192
46mitotic G2 DNA damage checkpoint (GO:0007095)3.15800220
47regulation of histone phosphorylation (GO:0033127)3.13183457
48signal peptide processing (GO:0006465)3.12065692
49acrosome assembly (GO:0001675)3.12062971
50double-strand break repair via homologous recombination (GO:0000724)3.11848280
51recombinational repair (GO:0000725)3.10290220
52defense response to protozoan (GO:0042832)3.09563574
53water-soluble vitamin biosynthetic process (GO:0042364)3.07276437
54epithelial cilium movement (GO:0003351)3.03208832
55keratinocyte development (GO:0003334)3.02741982
56positive regulation of protein autophosphorylation (GO:0031954)3.02379971
57regulation of hexokinase activity (GO:1903299)3.00847257
58regulation of glucokinase activity (GO:0033131)3.00847257
59positive regulation of glycoprotein biosynthetic process (GO:0010560)2.99890169
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99231252
61regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.99013749
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.98589123
63meiotic chromosome segregation (GO:0045132)2.96743671
64response to interferon-beta (GO:0035456)2.93926034
65regulation of RIG-I signaling pathway (GO:0039535)2.92933102
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92523939
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92523939
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.92523939
69DNA replication-dependent nucleosome organization (GO:0034723)2.92171368
70DNA replication-dependent nucleosome assembly (GO:0006335)2.92171368
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92131659
72regulation of helicase activity (GO:0051095)2.92021066
73sister chromatid cohesion (GO:0007062)2.91733863
74female gonad development (GO:0008585)2.90821292
75DNA replication-independent nucleosome assembly (GO:0006336)2.90786206
76DNA replication-independent nucleosome organization (GO:0034724)2.90786206
77regulation of meiosis I (GO:0060631)2.90554636
78maturation of 5.8S rRNA (GO:0000460)2.90448405
79single strand break repair (GO:0000012)2.89966089
80branched-chain amino acid catabolic process (GO:0009083)2.89734334
81response to X-ray (GO:0010165)2.89473969
82response to protozoan (GO:0001562)2.88019206
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87070393
84protein K6-linked ubiquitination (GO:0085020)2.86377431
85positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.85701012
86metaphase plate congression (GO:0051310)2.85636446
87spindle checkpoint (GO:0031577)2.83376271
88single fertilization (GO:0007338)2.82809953
89piRNA metabolic process (GO:0034587)2.79837606
90neural tube formation (GO:0001841)2.78791104
91respiratory chain complex IV assembly (GO:0008535)2.78746689
92motile cilium assembly (GO:0044458)2.78617853
93regulation of acyl-CoA biosynthetic process (GO:0050812)2.78278541
94resolution of meiotic recombination intermediates (GO:0000712)2.78199707
95mast cell activation (GO:0045576)2.76799985
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76487806
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76487806
98telomere maintenance via recombination (GO:0000722)2.75581655
99acrosome reaction (GO:0007340)2.75120750
100kinetochore organization (GO:0051383)2.74295320
101attachment of spindle microtubules to kinetochore (GO:0008608)2.74014989
102rRNA methylation (GO:0031167)2.73620560
103endosome to melanosome transport (GO:0035646)2.73528069
104endosome to pigment granule transport (GO:0043485)2.73528069
105mitotic spindle checkpoint (GO:0071174)2.72808538
106necroptotic process (GO:0070266)2.71225366
107regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70906062
108spermatid development (GO:0007286)2.68040166
109fucose catabolic process (GO:0019317)2.66410901
110L-fucose metabolic process (GO:0042354)2.66410901
111L-fucose catabolic process (GO:0042355)2.66410901
112male meiosis (GO:0007140)2.65015872
113regulation of mitotic sister chromatid separation (GO:0010965)2.64968808
114regulation of mitotic sister chromatid segregation (GO:0033047)2.64968808
115regulation of sister chromatid segregation (GO:0033045)2.64968808
116regulation of sulfur metabolic process (GO:0042762)2.64801713
117negative regulation of DNA recombination (GO:0045910)2.64678539
118double-strand break repair via nonhomologous end joining (GO:0006303)2.63918302
119non-recombinational repair (GO:0000726)2.63918302
120ribosome assembly (GO:0042255)2.63470838
121telomere maintenance via semi-conservative replication (GO:0032201)2.61767057
122histone H2A acetylation (GO:0043968)2.60250659
123centriole replication (GO:0007099)2.59159053
124mitotic metaphase plate congression (GO:0007080)2.58344389
125positive regulation of B cell differentiation (GO:0045579)2.57018667
126regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.56932733
127mast cell degranulation (GO:0043303)2.56011804
128mast cell activation involved in immune response (GO:0002279)2.56011804
129somatic recombination of immunoglobulin gene segments (GO:0016447)2.55999849
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.55619225
131negative regulation of sister chromatid segregation (GO:0033046)2.55619225
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55619225
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55619225
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55619225
135DNA catabolic process, exonucleolytic (GO:0000738)2.54407253
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.54316724
137regulation of translation, ncRNA-mediated (GO:0045974)2.54316724
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54316724
139somatic diversification of immunoglobulins (GO:0016445)2.53978482
140protein K11-linked ubiquitination (GO:0070979)2.53274484
141double-strand break repair (GO:0006302)2.53024312
142tRNA methylation (GO:0030488)2.51841996
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.51756193
144proteasome assembly (GO:0043248)2.51443123
145regulation of mesoderm development (GO:2000380)2.50406906
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50308962
147establishment of protein localization to Golgi (GO:0072600)2.50254744
148secretory granule organization (GO:0033363)2.47355657
149spermatid nucleus differentiation (GO:0007289)2.46401929
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45830448
151myeloid dendritic cell activation (GO:0001773)2.45111201
152epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43067080
153CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41617957
154kinetochore assembly (GO:0051382)2.41164272
155meiotic cell cycle (GO:0051321)2.40341888
156histone mRNA metabolic process (GO:0008334)2.38858644
157regulation of necroptotic process (GO:0060544)2.38675283
158N-terminal protein amino acid acetylation (GO:0006474)2.38563810
159positive regulation of T cell mediated cytotoxicity (GO:0001916)2.37404894
160purine-containing compound salvage (GO:0043101)2.36128833
161exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.35387799
162mitotic recombination (GO:0006312)2.35240983
163programmed necrotic cell death (GO:0097300)2.35150757
164centriole assembly (GO:0098534)2.32521175
165RNA methylation (GO:0001510)2.31706748
166positive regulation of mitochondrial fission (GO:0090141)2.31053191
167antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.30613933
168antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.30613933
169replication fork processing (GO:0031297)2.28912143
170T cell lineage commitment (GO:0002360)2.28795520
171positive regulation of T cell chemotaxis (GO:0010820)2.28775306
172regulation of T cell chemotaxis (GO:0010819)2.28775306
173T cell homeostasis (GO:0043029)2.27977384
174nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.27808649
175mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.26585778
176mitochondrial respiratory chain complex I assembly (GO:0032981)2.26585778
177NADH dehydrogenase complex assembly (GO:0010257)2.26585778
178negative regulation of viral genome replication (GO:0045071)2.26294976
179regulation of T cell mediated cytotoxicity (GO:0001914)2.25911196
180establishment of integrated proviral latency (GO:0075713)2.25672354
181translational termination (GO:0006415)2.23639501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.11817040
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.22115133
3SCL_19346495_ChIP-Seq_HPC-7_Human3.03255004
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87795419
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71880987
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60032413
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58015253
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50001391
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45081830
10VDR_22108803_ChIP-Seq_LS180_Human2.40282886
11ZNF274_21170338_ChIP-Seq_K562_Hela2.37567318
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.35973627
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.33456551
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32422164
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.27977490
16GBX2_23144817_ChIP-Seq_PC3_Human2.24749439
17* P300_19829295_ChIP-Seq_ESCs_Human2.24626975
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.20426483
19TAF15_26573619_Chip-Seq_HEK293_Human2.19700726
20* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.16040348
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.08007672
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07829943
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06441357
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05047453
25* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02740535
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00933038
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99553578
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98862637
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95284193
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.92164140
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91169216
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87595706
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87030011
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.84371673
35VDR_23849224_ChIP-Seq_CD4+_Human1.83886189
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83535339
37FUS_26573619_Chip-Seq_HEK293_Human1.81446575
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77672453
39ELK1_19687146_ChIP-ChIP_HELA_Human1.77470978
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73745605
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72237566
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68934284
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68129388
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67800235
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66908655
46ER_23166858_ChIP-Seq_MCF-7_Human1.66790503
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66393690
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.64456747
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.64000770
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58008755
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57302832
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.57007278
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55582406
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54865424
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53756425
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53047265
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52102733
58IGF1R_20145208_ChIP-Seq_DFB_Human1.51320207
59FOXP3_21729870_ChIP-Seq_TREG_Human1.50825329
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.49789768
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49453774
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49331045
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49123155
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.47033797
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46259368
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.45558089
67CBP_20019798_ChIP-Seq_JUKART_Human1.45082641
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45082641
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43843892
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40708006
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40213517
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39608019
73SPI1_23547873_ChIP-Seq_NB4_Human1.38618710
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.38367758
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37224609
76BCAT_22108803_ChIP-Seq_LS180_Human1.36884200
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36683877
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36644511
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35327255
80NANOG_19829295_ChIP-Seq_ESCs_Human1.35293205
81SOX2_19829295_ChIP-Seq_ESCs_Human1.35293205
82EWS_26573619_Chip-Seq_HEK293_Human1.34288407
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.34279359
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34021615
85STAT3_23295773_ChIP-Seq_U87_Human1.32422818
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31903475
87AR_25329375_ChIP-Seq_VCAP_Human1.31787851
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31639530
89MYC_18940864_ChIP-ChIP_HL60_Human1.29427010
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27647474
91CDX2_22108803_ChIP-Seq_LS180_Human1.27174846
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27055764
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26810530
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.26540502
95TCF4_22108803_ChIP-Seq_LS180_Human1.26101146
96* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25921776
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23898254
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22688400
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22578430
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22188552
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21572437
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.20864407
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20062998
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19079042
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.18955941
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.18594642
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17382048
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16798446
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.16685079
110* P53_22387025_ChIP-Seq_ESCs_Mouse1.16438265
111* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16191096
112TCF4_23295773_ChIP-Seq_U87_Human1.15040143
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12872806
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12279394
115IRF1_19129219_ChIP-ChIP_H3396_Human1.11331593
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11094677
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10670193
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10644368
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10311231
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.09873136
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.09828761
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09662781
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09502301
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08937454
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.08391686
126* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07145816
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.06498734
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06421969
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06421969
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06200278
131SALL4_22934838_ChIP-ChIP_CD34+_Human1.06139330
132NMYC_18555785_Chip-Seq_ESCs_Mouse1.06108993
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.04961966
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04441301
135RUNX2_22187159_ChIP-Seq_PCA_Human1.04023839
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03349935
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03326296
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03016151
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02965020
140P300_18555785_Chip-Seq_ESCs_Mouse1.00535678
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.99928745
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99594469
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99156739
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.98893238
145TP53_22573176_ChIP-Seq_HFKS_Human0.98834340
146MYB_26560356_Chip-Seq_TH2_Human0.98735934
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97770003
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97408827
149RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97318291
150STAT1_17558387_ChIP-Seq_HELA_Human0.97144324
151* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96984328
152ERG_20517297_ChIP-Seq_VCAP_Human0.96330660
153SOX2_18555785_Chip-Seq_ESCs_Mouse0.95735110
154EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95148545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.83018178
2MP0002396_abnormal_hematopoietic_system3.42765002
3MP0003787_abnormal_imprinting3.18993531
4MP0001835_abnormal_antigen_presentation3.18986959
5MP0005410_abnormal_fertilization3.14101445
6MP0009697_abnormal_copulation3.02567384
7MP0009785_altered_susceptibility_to2.86552430
8MP0004147_increased_porphyrin_level2.75415135
9MP0000569_abnormal_digit_pigmentation2.60313638
10MP0008877_abnormal_DNA_methylation2.57705412
11MP0005671_abnormal_response_to2.46748719
12MP0004808_abnormal_hematopoietic_stem2.42733592
13MP0003890_abnormal_embryonic-extraembry2.41833884
14MP0005174_abnormal_tail_pigmentation2.38484666
15MP0001545_abnormal_hematopoietic_system2.28008897
16MP0005397_hematopoietic_system_phenotyp2.28008897
17MP0010094_abnormal_chromosome_stability2.25626413
18MP0005075_abnormal_melanosome_morpholog2.24675019
19MP0002254_reproductive_system_inflammat2.22939961
20MP0005464_abnormal_platelet_physiology2.15964060
21MP0003763_abnormal_thymus_physiology2.10577713
22MP0006292_abnormal_olfactory_placode2.06515131
23MP0003786_premature_aging2.04304025
24MP0003941_abnormal_skin_development2.00583297
25MP0008058_abnormal_DNA_repair1.98594857
26MP0003693_abnormal_embryo_hatching1.94617990
27MP0006072_abnormal_retinal_apoptosis1.93941185
28MP0002095_abnormal_skin_pigmentation1.93382448
29MP0001929_abnormal_gametogenesis1.93377411
30MP0002398_abnormal_bone_marrow1.88325700
31MP0003724_increased_susceptibility_to1.83974024
32MP0008007_abnormal_cellular_replicative1.81935335
33MP0005025_abnormal_response_to1.81050719
34MP0000427_abnormal_hair_cycle1.80143188
35MP0002837_dystrophic_cardiac_calcinosis1.78471738
36MP0010234_abnormal_vibrissa_follicle1.77512038
37MP0001800_abnormal_humoral_immune1.73435335
38MP0002006_tumorigenesis1.73156588
39MP0000516_abnormal_urinary_system1.73001624
40MP0005367_renal/urinary_system_phenotyp1.73001624
41MP0000685_abnormal_immune_system1.72259675
42MP0002148_abnormal_hypersensitivity_rea1.71165805
43MP0005253_abnormal_eye_physiology1.70042107
44MP0003656_abnormal_erythrocyte_physiolo1.65035234
45MP0002723_abnormal_immune_serum1.63266294
46MP0004215_abnormal_myocardial_fiber1.61635244
47MP0000689_abnormal_spleen_morphology1.61051523
48MP0008995_early_reproductive_senescence1.60870814
49MP0003121_genomic_imprinting1.60679940
50MP0002452_abnormal_antigen_presenting1.60269057
51MP0002420_abnormal_adaptive_immunity1.59843346
52MP0001188_hyperpigmentation1.58277403
53MP0001819_abnormal_immune_cell1.57097026
54MP0003718_maternal_effect1.55724051
55MP0003698_abnormal_male_reproductive1.53517330
56MP0010678_abnormal_skin_adnexa1.53403033
57MP0003077_abnormal_cell_cycle1.50216388
58MP0002090_abnormal_vision1.49395367
59MP0002102_abnormal_ear_morphology1.48884789
60MP0000716_abnormal_immune_system1.47358651
61MP0001529_abnormal_vocalization1.46612424
62MP0008875_abnormal_xenobiotic_pharmacok1.46588226
63MP0005000_abnormal_immune_tolerance1.46479456
64MP0003943_abnormal_hepatobiliary_system1.46020957
65MP0002638_abnormal_pupillary_reflex1.45996763
66MP0000490_abnormal_crypts_of1.44979477
67MP0002210_abnormal_sex_determination1.44088279
68MP0002419_abnormal_innate_immunity1.43781682
69MP0005551_abnormal_eye_electrophysiolog1.42276917
70MP0002938_white_spotting1.40871029
71MP0002429_abnormal_blood_cell1.38721351
72MP0002722_abnormal_immune_system1.37134832
73MP0000015_abnormal_ear_pigmentation1.36987457
74MP0008057_abnormal_DNA_replication1.35551614
75MP0001853_heart_inflammation1.34094816
76MP0004510_myositis1.33473773
77MP0001119_abnormal_female_reproductive1.32438636
78MP0003186_abnormal_redox_activity1.29491463
79MP0004957_abnormal_blastocyst_morpholog1.28624024
80MP0000465_gastrointestinal_hemorrhage1.28529120
81MP0006036_abnormal_mitochondrial_physio1.28370001
82MP0000647_abnormal_sebaceous_gland1.27429784
83MP0005408_hypopigmentation1.27165377
84MP0003646_muscle_fatigue1.26700283
85MP0009379_abnormal_foot_pigmentation1.25436080
86MP0006054_spinal_hemorrhage1.25055174
87MP0000653_abnormal_sex_gland1.23975640
88MP0009333_abnormal_splenocyte_physiolog1.23114415
89MP0002166_altered_tumor_susceptibility1.22513167
90MP0001764_abnormal_homeostasis1.20352324
91MP0003111_abnormal_nucleus_morphology1.18280083
92MP0002736_abnormal_nociception_after1.18109728
93MP0000703_abnormal_thymus_morphology1.18020568
94MP0003937_abnormal_limbs/digits/tail_de1.17961872
95MP0010307_abnormal_tumor_latency1.17571734
96MP0005451_abnormal_body_composition1.17282528
97MP0009764_decreased_sensitivity_to1.17256301
98MP0003436_decreased_susceptibility_to1.16434626
99MP0008872_abnormal_physiological_respon1.15886499
100MP0000383_abnormal_hair_follicle1.14601097
101MP0001986_abnormal_taste_sensitivity1.12759286
102MP0001984_abnormal_olfaction1.12257123
103MP0001905_abnormal_dopamine_level1.10552796
104MP0002751_abnormal_autonomic_nervous1.09938471
105MP0001145_abnormal_male_reproductive1.08783156
106MP0001485_abnormal_pinna_reflex1.06635687
107MP0005379_endocrine/exocrine_gland_phen1.06059855
108MP0000566_synostosis1.05685435
109MP0003880_abnormal_central_pattern1.05435804
110MP0001790_abnormal_immune_system1.03142802
111MP0005387_immune_system_phenotype1.03142802
112MP0001873_stomach_inflammation1.03095531
113MP0002139_abnormal_hepatobiliary_system1.02100578
114MP0001293_anophthalmia1.01384841
115MP0008469_abnormal_protein_level1.00397812
116MP0003567_abnormal_fetal_cardiomyocyte1.00275185
117MP0010155_abnormal_intestine_physiology1.00020746
118MP0001845_abnormal_inflammatory_respons0.99343330
119MP0005646_abnormal_pituitary_gland0.98613245
120MP0003806_abnormal_nucleotide_metabolis0.97442322
121MP0005395_other_phenotype0.96747752
122MP0003119_abnormal_digestive_system0.94343195
123MP0002019_abnormal_tumor_incidence0.94022130
124MP0005248_abnormal_Harderian_gland0.93783038
125MP0005220_abnormal_exocrine_pancreas0.93767395
126MP0002161_abnormal_fertility/fecundity0.93732694
127MP0008775_abnormal_heart_ventricle0.93717766
128MP0000372_irregular_coat_pigmentation0.92321010
129MP0005389_reproductive_system_phenotype0.92115219
130MP0008932_abnormal_embryonic_tissue0.91418565
131MP0001919_abnormal_reproductive_system0.90725634
132MP0004484_altered_response_of0.87883575
133MP0006035_abnormal_mitochondrial_morpho0.86783376
134MP0002160_abnormal_reproductive_system0.86094978
135MP0009765_abnormal_xenobiotic_induced0.85455941
136MP0005084_abnormal_gallbladder_morpholo0.84533789
137MP0001324_abnormal_eye_pigmentation0.84335343
138MP0002876_abnormal_thyroid_physiology0.84232139
139MP0003950_abnormal_plasma_membrane0.82573846
140MP0005647_abnormal_sex_gland0.81774113
141MP0002405_respiratory_system_inflammati0.81229420
142MP0004782_abnormal_surfactant_physiolog0.80121593
143MP0002132_abnormal_respiratory_system0.79913309
144MP0008789_abnormal_olfactory_epithelium0.79343304
145MP0005636_abnormal_mineral_homeostasis0.78801045
146MP0009046_muscle_twitch0.78419805
147MP0001968_abnormal_touch/_nociception0.78318293
148MP0000613_abnormal_salivary_gland0.78135954
149MP0002877_abnormal_melanocyte_morpholog0.77818679
150MP0005187_abnormal_penis_morphology0.77111987
151MP0003699_abnormal_female_reproductive0.77088998
152MP0002233_abnormal_nose_morphology0.74632242
153MP0009763_increased_sensitivity_to0.74504556
154MP0003183_abnormal_peptide_metabolism0.73966429
155MP0005645_abnormal_hypothalamus_physiol0.73817786
156MP0002234_abnormal_pharynx_morphology0.72387739
157MP0003252_abnormal_bile_duct0.72118717
158MP0003011_delayed_dark_adaptation0.72044337
159MP0010386_abnormal_urinary_bladder0.70868663
160MP0004133_heterotaxia0.70086716
161MP0000631_abnormal_neuroendocrine_gland0.70027832
162MP0001177_atelectasis0.67570280
163MP0009703_decreased_birth_body0.67108653

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.09819880
2Aplastic anemia (HP:0001915)3.97009899
3Abnormality of the heme biosynthetic pathway (HP:0010472)3.89318731
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.82906880
5Absent/shortened dynein arms (HP:0200106)3.82906880
6Acanthocytosis (HP:0001927)3.60766531
7Acute myeloid leukemia (HP:0004808)3.38343262
8Thrombocytosis (HP:0001894)3.36751404
9Birth length less than 3rd percentile (HP:0003561)3.32323125
10Type 2 muscle fiber atrophy (HP:0003554)3.18081804
11Abnormality of the labia minora (HP:0012880)3.14295307
12Myositis (HP:0100614)3.02722177
13Abnormal respiratory epithelium morphology (HP:0012253)3.01670622
14Abnormal respiratory motile cilium morphology (HP:0005938)3.01670622
15Intestinal atresia (HP:0011100)3.00639194
16Abnormality of the prostate (HP:0008775)2.99357567
17Methylmalonic acidemia (HP:0002912)2.98494232
183-Methylglutaconic aciduria (HP:0003535)2.96085942
19Fair hair (HP:0002286)2.96015106
20Abnormal respiratory motile cilium physiology (HP:0012261)2.88076335
21Petechiae (HP:0000967)2.88064232
22Muscle fiber atrophy (HP:0100295)2.81116026
23Prolonged bleeding time (HP:0003010)2.78391288
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.70955304
25Hypoplasia of the fovea (HP:0007750)2.70955304
26Hypothermia (HP:0002045)2.69219936
27Elevated erythrocyte sedimentation rate (HP:0003565)2.68169071
28Abnormality of the fovea (HP:0000493)2.64508870
29Abnormality of methionine metabolism (HP:0010901)2.60608649
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59139256
31Prostate neoplasm (HP:0100787)2.57994617
32Myelodysplasia (HP:0002863)2.53357685
33Pancreatic fibrosis (HP:0100732)2.50367761
34Self-mutilation (HP:0000742)2.48683951
35Chromsome breakage (HP:0040012)2.48305024
36Abnormal spermatogenesis (HP:0008669)2.46279012
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.43111600
38Thyroiditis (HP:0100646)2.40946598
39Abnormal hair whorl (HP:0010721)2.40225251
40Rhinitis (HP:0012384)2.38318010
41IgM deficiency (HP:0002850)2.37268200
42Infertility (HP:0000789)2.36159743
43Abnormality of midbrain morphology (HP:0002418)2.35720745
44Molar tooth sign on MRI (HP:0002419)2.35720745
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35448191
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35448191
47Renal Fanconi syndrome (HP:0001994)2.34197699
48Abnormality of the renal cortex (HP:0011035)2.33813563
49Epistaxis (HP:0000421)2.33262409
50Spontaneous abortion (HP:0005268)2.32685464
51Retrobulbar optic neuritis (HP:0100654)2.30903329
52Optic neuritis (HP:0100653)2.30903329
53True hermaphroditism (HP:0010459)2.30455798
54Abnormal ciliary motility (HP:0012262)2.30330074
55Meckel diverticulum (HP:0002245)2.28740836
56Progressive inability to walk (HP:0002505)2.28496709
57Volvulus (HP:0002580)2.26627076
58Chronic otitis media (HP:0000389)2.25524669
59Neoplasm of the adrenal gland (HP:0100631)2.24574610
60Neoplasm of the adrenal cortex (HP:0100641)2.23989937
61Increased hepatocellular lipid droplets (HP:0006565)2.22872995
62Pancreatic cysts (HP:0001737)2.22391826
63Reduced antithrombin III activity (HP:0001976)2.21572187
64Exertional dyspnea (HP:0002875)2.21381788
65Recurrent bronchitis (HP:0002837)2.21245631
66Medial flaring of the eyebrow (HP:0010747)2.21190584
67Pancreatic islet-cell hyperplasia (HP:0004510)2.20933284
68Abnormality of the ileum (HP:0001549)2.19379129
69Abnormal lung lobation (HP:0002101)2.18900747
70Breast carcinoma (HP:0003002)2.18491158
71Gingival bleeding (HP:0000225)2.17835422
72Bronchitis (HP:0012387)2.17611556
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17276661
74Abnormality of vitamin B metabolism (HP:0004340)2.17040721
75Orchitis (HP:0100796)2.14415199
76Recurrent bacterial skin infections (HP:0005406)2.14357704
77Clubbing of toes (HP:0100760)2.14103198
78Poikilocytosis (HP:0004447)2.12806573
79Ependymoma (HP:0002888)2.12520215
80Type I transferrin isoform profile (HP:0003642)2.12190163
81Chronic bronchitis (HP:0004469)2.12160444
82Generalized hypopigmentation of hair (HP:0011358)2.11261810
83Biliary tract neoplasm (HP:0100574)2.10776626
84Sloping forehead (HP:0000340)2.10513262
85Encephalitis (HP:0002383)2.09810568
86Vasculitis (HP:0002633)2.08343322
87Chronic hepatic failure (HP:0100626)2.07241722
88Rhabdomyosarcoma (HP:0002859)2.06696381
89Hypochromic microcytic anemia (HP:0004840)2.06266503
90Abnormal biliary tract morphology (HP:0012440)2.05726190
91Abnormality of the duodenum (HP:0002246)2.05524677
92Aqueductal stenosis (HP:0002410)2.05406120
93Colon cancer (HP:0003003)2.05261428
94Thyroid carcinoma (HP:0002890)2.03432926
95Aplasia/Hypoplasia of the tongue (HP:0010295)2.03295245
96Pallor (HP:0000980)2.02828243
97Progressive macrocephaly (HP:0004481)2.02821906
98Hepatocellular necrosis (HP:0001404)2.00469754
99Duodenal stenosis (HP:0100867)1.99682634
100Small intestinal stenosis (HP:0012848)1.99682634
101Abnormality of the renal medulla (HP:0100957)1.99198969
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99136511
103Bronchiectasis (HP:0002110)1.98033808
104Recurrent sinusitis (HP:0011108)1.97970334
105Purpura (HP:0000979)1.97760809
106Nasal polyposis (HP:0100582)1.97648013
107Abolished electroretinogram (ERG) (HP:0000550)1.97647767
108Abnormality of macular pigmentation (HP:0008002)1.97619853
109Glioma (HP:0009733)1.96791271
110Pulmonary fibrosis (HP:0002206)1.95913478
111Respiratory difficulties (HP:0002880)1.95432931
112Abnormality of the vitamin B12 metabolism (HP:0004341)1.95336162
113Pancytopenia (HP:0001876)1.94143207
114Methylmalonic aciduria (HP:0012120)1.91633597
115Lipid accumulation in hepatocytes (HP:0006561)1.91163258
116Mitochondrial inheritance (HP:0001427)1.90991983
117Nonprogressive disorder (HP:0003680)1.90963608
118Small hand (HP:0200055)1.90268273
119Genital tract atresia (HP:0001827)1.90082896
120Reticulocytopenia (HP:0001896)1.89286898
121Keratoconjunctivitis sicca (HP:0001097)1.89220236
122Embryonal renal neoplasm (HP:0011794)1.88185381
123IgG deficiency (HP:0004315)1.88044933
124Abnormality of renal resorption (HP:0011038)1.87069042
125Supernumerary spleens (HP:0009799)1.86846917
126Abnormal number of erythroid precursors (HP:0012131)1.86805073
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86400627
128Attenuation of retinal blood vessels (HP:0007843)1.85591740
129Acute necrotizing encephalopathy (HP:0006965)1.85544915
130Recurrent abscess formation (HP:0002722)1.85390609
131Abnormality of T cell physiology (HP:0011840)1.84259774
132Abnormality of chromosome stability (HP:0003220)1.83794013
133Microcytic anemia (HP:0001935)1.82945715
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82818403
135Erythema (HP:0010783)1.82769862
136Gonadotropin excess (HP:0000837)1.82569697
137Ovarian neoplasm (HP:0100615)1.81951925
138Hyperinsulinemic hypoglycemia (HP:0000825)1.81767789
139Inappropriate behavior (HP:0000719)1.81634963
140Nephronophthisis (HP:0000090)1.80572474
141Abnormality of cells of the erythroid lineage (HP:0012130)1.80281777
142Abnormality of serum amino acid levels (HP:0003112)1.79699749
143Hepatic necrosis (HP:0002605)1.79571028
144Abnormality of the preputium (HP:0100587)1.78961984
145Disinhibition (HP:0000734)1.77894822
146Agammaglobulinemia (HP:0004432)1.76849579
147Nephroblastoma (Wilms tumor) (HP:0002667)1.76586620
148Gaze-evoked nystagmus (HP:0000640)1.75984717
149Acute lymphatic leukemia (HP:0006721)1.75675307
150Renal cortical cysts (HP:0000803)1.75477279
151Weak cry (HP:0001612)1.75168153
152Protruding tongue (HP:0010808)1.75122510
153Congenital stationary night blindness (HP:0007642)1.75077657
154Keratoconjunctivitis (HP:0001096)1.75036057
155Acute encephalopathy (HP:0006846)1.74815377
156Bifid tongue (HP:0010297)1.74473664
157Tubulointerstitial nephritis (HP:0001970)1.74308678
158Labial hypoplasia (HP:0000066)1.73850858
159Vaginal atresia (HP:0000148)1.73298562
160Anencephaly (HP:0002323)1.72187387
161Abnormality of the astrocytes (HP:0100707)1.71284801
162Astrocytoma (HP:0009592)1.71284801
163Hypoplastic labia majora (HP:0000059)1.70773267
164Furrowed tongue (HP:0000221)1.69549107
165Hypoproteinemia (HP:0003075)1.69493050
166Hypoglycemic seizures (HP:0002173)1.69355113
167Increased CSF lactate (HP:0002490)1.68549689
168Curly hair (HP:0002212)1.67825944
169Sclerocornea (HP:0000647)1.67527345
170Abnormality of endocrine pancreas physiology (HP:0012093)1.67434686
171Abnormality of the pancreatic islet cells (HP:0006476)1.67434686
172Optic nerve hypoplasia (HP:0000609)1.66547319
173Hypoplastic female external genitalia (HP:0012815)1.66448544
174Papillary thyroid carcinoma (HP:0002895)1.63564222
175Hypomagnesemia (HP:0002917)1.62762679
176Congenital primary aphakia (HP:0007707)1.62238098
177Long clavicles (HP:0000890)1.61681823
178Aplasia/Hypoplasia of the tibia (HP:0005772)1.61217171
179Male pseudohermaphroditism (HP:0000037)1.61088259
180Aplasia/Hypoplasia of the macula (HP:0008059)1.61067893
181Abnormal biliary tract physiology (HP:0012439)1.60973955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.56247853
2MUSK3.21549906
3MAP3K123.11124190
4KIT2.81589058
5WNK32.77936943
6STK162.75881829
7MAP4K22.73434913
8ERBB32.45626024
9PDK42.38949676
10PDK32.38949676
11TNIK2.33689695
12TXK2.32818811
13PLK42.27228967
14CDK82.26177093
15MAP3K62.22065237
16ACVR1B2.16435411
17PLK32.08885432
18CDK192.04591117
19CCNB11.93421743
20VRK11.90468122
21CDC71.89556173
22BCR1.84970100
23MAP2K71.82733407
24BRSK21.78841219
25TEC1.75731963
26BMPR1B1.74127896
27MAP4K11.72475816
28FLT31.72395613
29TGFBR11.69726850
30EIF2AK11.69248831
31WEE11.58290145
32CSF1R1.57128399
33STK38L1.55211212
34GRK11.54107688
35MKNK11.50254404
36SIK31.44146876
37JAK31.42431245
38TAOK31.39903910
39MAP3K141.39588122
40PBK1.33837577
41IRAK41.33454192
42OXSR11.32696784
43NEK91.30719430
44CASK1.30179310
45TSSK61.25999756
46STK391.24496869
47TAF11.21591761
48BTK1.19867826
49SYK1.16991974
50TTK1.14820502
51SRPK11.14116216
52NEK11.10626266
53IKBKE1.10604919
54MATK1.09963986
55STK241.07337434
56MYLK1.06069035
57PDK21.03706128
58MAPKAPK51.02957413
59NLK1.00828373
60NUAK10.99677523
61ERBB40.97614082
62ZAP700.96589841
63MAP3K40.95726702
64CDK30.94955173
65BMPR20.94609983
66PIK3CA0.93571021
67PAK30.90553436
68MAP2K60.88018862
69FGFR20.87934817
70EIF2AK30.87098738
71NME20.86091247
72DYRK30.85812120
73CSNK1G10.81459502
74MKNK20.78988348
75FRK0.75538975
76MST40.75199669
77MAPK130.74571773
78BRAF0.74412854
79PNCK0.73955383
80EIF2AK20.73143651
81PTK2B0.72065792
82CSNK1G20.71910428
83PRKCE0.70056083
84FER0.69517887
85STK30.68097140
86LYN0.67559425
87ADRBK20.66671908
88ATR0.64030516
89LCK0.63636407
90PIK3CG0.62755704
91BRSK10.62570081
92AKT30.62037113
93CHEK20.61938334
94RPS6KB20.61917131
95TIE10.60740194
96IKBKB0.60161754
97CSNK1G30.59593944
98EEF2K0.57857979
99MAP2K40.56755905
100RAF10.55887963
101MAP2K30.54652903
102AURKB0.53518112
103TRPM70.52314156
104EPHA30.52255731
105RPS6KA40.51108217
106TBK10.50786847
107PIM20.50648081
108ATM0.49732613
109INSRR0.48870282
110PLK20.48846033
111PIM10.48250984
112CSNK1A1L0.48165650
113YES10.46930144
114STK100.46052518
115MINK10.45380931
116FGFR30.45020322
117MAP3K130.44750562
118BUB10.44722651
119NEK60.44410093
120CSNK2A10.43263271
121OBSCN0.42881545
122CDK90.42219389
123PLK10.41580527
124CHUK0.40823219
125PINK10.40032287
126VRK20.39610500
127GRK70.39572210
128BCKDK0.38801413
129KSR10.38710293
130ABL20.38645500
131ZAK0.38203794
132STK40.37892741
133CDK70.37778148
134RPS6KA50.37491849
135BRD40.37236829
136DYRK20.37072765
137PRKCG0.34646423
138SGK20.33356164
139PRKCI0.33240535
140EGFR0.30408844
141GRK50.30406473
142CAMKK20.28218609
143ABL10.25834113
144ERBB20.25733136
145ADRBK10.25482359
146FGFR10.24127098
147MARK30.24077395
148IGF1R0.21730689
149CSNK1A10.21674866
150FGR0.20260131

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.35203621
2Ribosome_Homo sapiens_hsa030102.88541857
3RNA degradation_Homo sapiens_hsa030182.71267606
4Mismatch repair_Homo sapiens_hsa034302.70563614
5Homologous recombination_Homo sapiens_hsa034402.68412597
6Basal transcription factors_Homo sapiens_hsa030222.47764188
7Proteasome_Homo sapiens_hsa030502.44228803
8Pyrimidine metabolism_Homo sapiens_hsa002402.41086847
9RNA polymerase_Homo sapiens_hsa030202.29519785
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24887644
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24676170
12Base excision repair_Homo sapiens_hsa034102.19596560
13Nucleotide excision repair_Homo sapiens_hsa034202.17442331
14Cell cycle_Homo sapiens_hsa041102.08675527
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01888880
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.99841510
17Non-homologous end-joining_Homo sapiens_hsa034501.92057965
18Protein export_Homo sapiens_hsa030601.89442191
19Graft-versus-host disease_Homo sapiens_hsa053321.82782315
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81278561
21Fanconi anemia pathway_Homo sapiens_hsa034601.78776089
22Butanoate metabolism_Homo sapiens_hsa006501.69047961
23Phototransduction_Homo sapiens_hsa047441.68085456
24Nitrogen metabolism_Homo sapiens_hsa009101.67201099
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64740597
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62869003
27Primary immunodeficiency_Homo sapiens_hsa053401.60987420
28Herpes simplex infection_Homo sapiens_hsa051681.54624884
29Purine metabolism_Homo sapiens_hsa002301.54436161
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.53300463
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49961903
32Hematopoietic cell lineage_Homo sapiens_hsa046401.49419919
33Allograft rejection_Homo sapiens_hsa053301.46006584
34Measles_Homo sapiens_hsa051621.45406538
35Spliceosome_Homo sapiens_hsa030401.44786511
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44357722
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43526740
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.40454226
39Leishmaniasis_Homo sapiens_hsa051401.39693334
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38321820
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33379367
42One carbon pool by folate_Homo sapiens_hsa006701.32249707
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30066690
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.29081572
45RNA transport_Homo sapiens_hsa030131.25226278
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20563414
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.16062445
48Caffeine metabolism_Homo sapiens_hsa002321.12286283
49Tryptophan metabolism_Homo sapiens_hsa003801.09238180
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08794216
51Type I diabetes mellitus_Homo sapiens_hsa049401.07610226
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06402896
53Pyruvate metabolism_Homo sapiens_hsa006201.01472010
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00063651
55Antigen processing and presentation_Homo sapiens_hsa046120.95918473
56Legionellosis_Homo sapiens_hsa051340.95469292
57Fatty acid elongation_Homo sapiens_hsa000620.94606407
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94428523
59p53 signaling pathway_Homo sapiens_hsa041150.94412279
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93746436
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92808204
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91039830
63African trypanosomiasis_Homo sapiens_hsa051430.89262908
64Circadian rhythm_Homo sapiens_hsa047100.88923898
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.88764246
66Propanoate metabolism_Homo sapiens_hsa006400.88691476
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86871439
68Huntingtons disease_Homo sapiens_hsa050160.86413096
69Systemic lupus erythematosus_Homo sapiens_hsa053220.86136937
70Rheumatoid arthritis_Homo sapiens_hsa053230.85332074
71Retinol metabolism_Homo sapiens_hsa008300.85304319
72Oxidative phosphorylation_Homo sapiens_hsa001900.84992062
73Folate biosynthesis_Homo sapiens_hsa007900.83801541
74Sulfur metabolism_Homo sapiens_hsa009200.83173668
75Peroxisome_Homo sapiens_hsa041460.82578398
76Influenza A_Homo sapiens_hsa051640.81968226
77Regulation of autophagy_Homo sapiens_hsa041400.81659788
78Malaria_Homo sapiens_hsa051440.79515844
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78785659
80Ether lipid metabolism_Homo sapiens_hsa005650.78531767
81Collecting duct acid secretion_Homo sapiens_hsa049660.77189688
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77108946
83Parkinsons disease_Homo sapiens_hsa050120.75686959
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.75613434
85Fatty acid metabolism_Homo sapiens_hsa012120.75074899
86Shigellosis_Homo sapiens_hsa051310.74964115
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72572568
88Olfactory transduction_Homo sapiens_hsa047400.71709731
89beta-Alanine metabolism_Homo sapiens_hsa004100.71049948
90Epstein-Barr virus infection_Homo sapiens_hsa051690.70371816
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70319087
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69319680
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68563266
94TGF-beta signaling pathway_Homo sapiens_hsa043500.67966365
95Fatty acid degradation_Homo sapiens_hsa000710.64847532
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.63250631
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.62866412
98Arachidonic acid metabolism_Homo sapiens_hsa005900.60752692
99Hepatitis B_Homo sapiens_hsa051610.60134932
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58120610
101B cell receptor signaling pathway_Homo sapiens_hsa046620.56905628
102mRNA surveillance pathway_Homo sapiens_hsa030150.54612551
103Chemical carcinogenesis_Homo sapiens_hsa052040.53859855
104Histidine metabolism_Homo sapiens_hsa003400.53678997
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52856488
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51939992
107Metabolic pathways_Homo sapiens_hsa011000.51719364
108Oocyte meiosis_Homo sapiens_hsa041140.51377620
109Pertussis_Homo sapiens_hsa051330.51359533
110Platelet activation_Homo sapiens_hsa046110.50823164
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50275227
112TNF signaling pathway_Homo sapiens_hsa046680.50203361
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48895980
114Nicotine addiction_Homo sapiens_hsa050330.45996441
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45917399
116N-Glycan biosynthesis_Homo sapiens_hsa005100.45715419
117Serotonergic synapse_Homo sapiens_hsa047260.45389227
118Selenocompound metabolism_Homo sapiens_hsa004500.45064013
119Alzheimers disease_Homo sapiens_hsa050100.44613321
120Glutathione metabolism_Homo sapiens_hsa004800.44351890
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44271287
122Ovarian steroidogenesis_Homo sapiens_hsa049130.43617684
123Osteoclast differentiation_Homo sapiens_hsa043800.43318443
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42848221
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42398312
126Toxoplasmosis_Homo sapiens_hsa051450.41863597
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40083600
128Other glycan degradation_Homo sapiens_hsa005110.39808639
129Linoleic acid metabolism_Homo sapiens_hsa005910.39151331
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38973610
131Sphingolipid metabolism_Homo sapiens_hsa006000.38844590
132Thyroid cancer_Homo sapiens_hsa052160.37611071
133Steroid biosynthesis_Homo sapiens_hsa001000.37475916
134Vitamin B6 metabolism_Homo sapiens_hsa007500.34081291
135Taste transduction_Homo sapiens_hsa047420.31876431
136Vitamin digestion and absorption_Homo sapiens_hsa049770.28804710
137Asthma_Homo sapiens_hsa053100.28068087
138ABC transporters_Homo sapiens_hsa020100.27512423
139Mineral absorption_Homo sapiens_hsa049780.25519416
140Hedgehog signaling pathway_Homo sapiens_hsa043400.24021090
141Starch and sucrose metabolism_Homo sapiens_hsa005000.22761230

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