

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | actin filament-based movement (GO:0030048) | 5.28932499 |
| 2 | response to muscle activity (GO:0014850) | 4.99245777 |
| 3 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.63603636 |
| 4 | cardiac muscle hypertrophy (GO:0003300) | 4.58159481 |
| 5 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.53183729 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.49313512 |
| 7 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 4.44807549 |
| 8 | negative regulation of protein localization to cell surface (GO:2000009) | 4.44121878 |
| 9 | striated muscle hypertrophy (GO:0014897) | 4.39388897 |
| 10 | regulation of cell communication by electrical coupling (GO:0010649) | 4.29586221 |
| 11 | muscle contraction (GO:0006936) | 4.23816953 |
| 12 | detection of calcium ion (GO:0005513) | 4.14209710 |
| 13 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.11692376 |
| 14 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.07014087 |
| 15 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 4.03404152 |
| 16 | sarcomere organization (GO:0045214) | 3.99902256 |
| 17 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.98926743 |
| 18 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.97103138 |
| 19 | muscle tissue morphogenesis (GO:0060415) | 3.96247073 |
| 20 | muscle filament sliding (GO:0030049) | 3.88559753 |
| 21 | actin-myosin filament sliding (GO:0033275) | 3.88559753 |
| 22 | muscle fiber development (GO:0048747) | 3.87245002 |
| 23 | regulation of skeletal muscle contraction (GO:0014819) | 3.86406958 |
| 24 | cardiac muscle cell development (GO:0055013) | 3.80153442 |
| 25 | muscle system process (GO:0003012) | 3.79239723 |
| 26 | regulation of relaxation of muscle (GO:1901077) | 3.78674014 |
| 27 | myofibril assembly (GO:0030239) | 3.76049846 |
| 28 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.75419924 |
| 29 | muscle hypertrophy (GO:0014896) | 3.74683680 |
| 30 | regulation of actin filament-based movement (GO:1903115) | 3.67980845 |
| 31 | respiratory electron transport chain (GO:0022904) | 3.66504672 |
| 32 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.59539187 |
| 33 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.57368469 |
| 34 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.54744095 |
| 35 | electron transport chain (GO:0022900) | 3.54592851 |
| 36 | neuronal action potential propagation (GO:0019227) | 3.53906292 |
| 37 | fatty acid transmembrane transport (GO:1902001) | 3.51592097 |
| 38 | cardiac cell development (GO:0055006) | 3.49226443 |
| 39 | behavioral response to nicotine (GO:0035095) | 3.49120768 |
| 40 | skeletal muscle fiber development (GO:0048741) | 3.41761305 |
| 41 | positive regulation of action potential (GO:0045760) | 3.37789644 |
| 42 | 2-oxoglutarate metabolic process (GO:0006103) | 3.37649842 |
| 43 | ATP synthesis coupled proton transport (GO:0015986) | 3.37491105 |
| 44 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.37491105 |
| 45 | otic vesicle formation (GO:0030916) | 3.37281642 |
| 46 | skeletal muscle adaptation (GO:0043501) | 3.35013858 |
| 47 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.34256321 |
| 48 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.33104689 |
| 49 | aspartate family amino acid catabolic process (GO:0009068) | 3.32534933 |
| 50 | response to caffeine (GO:0031000) | 3.32347965 |
| 51 | striated muscle cell development (GO:0055002) | 3.31846274 |
| 52 | myotube cell development (GO:0014904) | 3.31747858 |
| 53 | striated muscle contraction (GO:0006941) | 3.31625951 |
| 54 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.31331655 |
| 55 | skeletal muscle contraction (GO:0003009) | 3.31267638 |
| 56 | regulation of membrane repolarization (GO:0060306) | 3.29639567 |
| 57 | creatine metabolic process (GO:0006600) | 3.28759523 |
| 58 | cardiac muscle contraction (GO:0060048) | 3.28449664 |
| 59 | cardiac muscle cell action potential (GO:0086001) | 3.26959997 |
| 60 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.25576599 |
| 61 | actin-mediated cell contraction (GO:0070252) | 3.23408520 |
| 62 | cardiac myofibril assembly (GO:0055003) | 3.22051379 |
| 63 | regulation of potassium ion transmembrane transporter activity (GO:1901016) | 3.21836783 |
| 64 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.21491834 |
| 65 | tricarboxylic acid cycle (GO:0006099) | 3.21135577 |
| 66 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.20532643 |
| 67 | regulation of the force of heart contraction (GO:0002026) | 3.19593439 |
| 68 | regulation of ATPase activity (GO:0043462) | 3.16543911 |
| 69 | regulation of ATP catabolic process (GO:1903289) | 3.16543911 |
| 70 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.14983151 |
| 71 | regulation of striated muscle contraction (GO:0006942) | 3.14483773 |
| 72 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.12752615 |
| 73 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.11749448 |
| 74 | carnitine transmembrane transport (GO:1902603) | 3.11190297 |
| 75 | cell communication by electrical coupling (GO:0010644) | 3.09731278 |
| 76 | regulation of action potential (GO:0098900) | 3.09359655 |
| 77 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.07466748 |
| 78 | striated muscle adaptation (GO:0014888) | 3.06853165 |
| 79 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.06235260 |
| 80 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.06235260 |
| 81 | regulation of heart rate (GO:0002027) | 3.05128116 |
| 82 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.99792747 |
| 83 | axon ensheathment in central nervous system (GO:0032291) | 2.99585089 |
| 84 | central nervous system myelination (GO:0022010) | 2.99585089 |
| 85 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.97005928 |
| 86 | regulation of sarcomere organization (GO:0060297) | 2.96297979 |
| 87 | response to epinephrine (GO:0071871) | 2.94982925 |
| 88 | response to inactivity (GO:0014854) | 2.94816741 |
| 89 | heart contraction (GO:0060047) | 2.93842845 |
| 90 | heart process (GO:0003015) | 2.93842845 |
| 91 | membrane depolarization during action potential (GO:0086010) | 2.91376071 |
| 92 | muscle cell development (GO:0055001) | 2.91192525 |
| 93 | cardiac muscle adaptation (GO:0014887) | 2.91121004 |
| 94 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 2.91121004 |
| 95 | muscle hypertrophy in response to stress (GO:0003299) | 2.91121004 |
| 96 | neuron cell-cell adhesion (GO:0007158) | 2.89301546 |
| 97 | synaptic vesicle exocytosis (GO:0016079) | 2.88557516 |
| 98 | regulation of cardiac muscle cell contraction (GO:0086004) | 2.87882950 |
| 99 | positive regulation of cation channel activity (GO:2001259) | 2.86781694 |
| 100 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 2.86631752 |
| 101 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 2.86631752 |
| 102 | cardiac chamber formation (GO:0003207) | 2.85872309 |
| 103 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.85802191 |
| 104 | negative regulation of potassium ion transport (GO:0043267) | 2.83487054 |
| 105 | cardiac ventricle formation (GO:0003211) | 2.83221307 |
| 106 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.82879523 |
| 107 | mitochondrial genome maintenance (GO:0000002) | 2.82850450 |
| 108 | regulation of cardiac muscle contraction (GO:0055117) | 2.82509890 |
| 109 | skeletal muscle tissue development (GO:0007519) | 2.80853151 |
| 110 | amino-acid betaine transport (GO:0015838) | 2.79975520 |
| 111 | carnitine transport (GO:0015879) | 2.79975520 |
| 112 | presynaptic membrane assembly (GO:0097105) | 2.79396552 |
| 113 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.77752291 |
| 114 | striatum development (GO:0021756) | 2.77166116 |
| 115 | membrane tubulation (GO:0097320) | 2.76999811 |
| 116 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.76838428 |
| 117 | plasma membrane repair (GO:0001778) | 2.76579182 |
| 118 | quinone biosynthetic process (GO:1901663) | 2.76005254 |
| 119 | ubiquinone biosynthetic process (GO:0006744) | 2.76005254 |
| 120 | regulation of dopamine metabolic process (GO:0042053) | 2.74010493 |
| 121 | regulation of catecholamine metabolic process (GO:0042069) | 2.74010493 |
| 122 | succinate metabolic process (GO:0006105) | 2.73231303 |
| 123 | regulation of cofactor metabolic process (GO:0051193) | 2.71122635 |
| 124 | regulation of coenzyme metabolic process (GO:0051196) | 2.71122635 |
| 125 | actomyosin structure organization (GO:0031032) | 2.70465653 |
| 126 | cellular response to epinephrine stimulus (GO:0071872) | 2.70421010 |
| 127 | neuronal action potential (GO:0019228) | 2.69635641 |
| 128 | long-chain fatty acid biosynthetic process (GO:0042759) | 2.68977467 |
| 129 | presynaptic membrane organization (GO:0097090) | 2.67343192 |
| 130 | regulation of cation channel activity (GO:2001257) | 2.66214395 |
| 131 | vocalization behavior (GO:0071625) | 2.63504284 |
| 132 | positive regulation of potassium ion transport (GO:0043268) | 2.63496591 |
| 133 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.61229871 |
| 134 | ubiquinone metabolic process (GO:0006743) | 2.60228609 |
| 135 | regulation of synapse structural plasticity (GO:0051823) | 2.58392002 |
| 136 | adult heart development (GO:0007512) | 2.56573861 |
| 137 | cell communication involved in cardiac conduction (GO:0086065) | 2.55748834 |
| 138 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.55680151 |
| 139 | neuron-neuron synaptic transmission (GO:0007270) | 2.55587899 |
| 140 | neuromuscular synaptic transmission (GO:0007274) | 2.54510773 |
| 141 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.53241428 |
| 142 | photoreceptor cell differentiation (GO:0046530) | 2.52152379 |
| 143 | eye photoreceptor cell differentiation (GO:0001754) | 2.52152379 |
| 144 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.51699065 |
| 145 | carnitine shuttle (GO:0006853) | 2.51693450 |
| 146 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.51453935 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.58104301 |
| 2 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.38978317 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.79052055 |
| 4 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.43726843 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.77122132 |
| 6 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.72623810 |
| 7 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.54289729 |
| 8 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.48462476 |
| 9 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.44744582 |
| 10 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.33074414 |
| 11 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.21220917 |
| 12 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.12978779 |
| 13 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.09825134 |
| 14 | VDR_22108803_ChIP-Seq_LS180_Human | 2.09692194 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.06237599 |
| 16 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.01374777 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.01149500 |
| 18 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.01100470 |
| 19 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.98607896 |
| 20 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.98073300 |
| 21 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.96867897 |
| 22 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.94372242 |
| 23 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.92670775 |
| 24 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.90719093 |
| 25 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.90038071 |
| 26 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.90038071 |
| 27 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.88476780 |
| 28 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.86526793 |
| 29 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.81899587 |
| 30 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.79719744 |
| 31 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.75735755 |
| 32 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.69813322 |
| 33 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.68735988 |
| 34 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.66861351 |
| 35 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.64931828 |
| 36 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.62955854 |
| 37 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.60345267 |
| 38 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.58909755 |
| 39 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.57490760 |
| 40 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.57011271 |
| 41 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.56732052 |
| 42 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.56688729 |
| 43 | P300_19829295_ChIP-Seq_ESCs_Human | 1.55766628 |
| 44 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.55254539 |
| 45 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.55013681 |
| 46 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.54518921 |
| 47 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.51676853 |
| 48 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.50564928 |
| 49 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.50203053 |
| 50 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.49365908 |
| 51 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.49260146 |
| 52 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.45628522 |
| 53 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.43757370 |
| 54 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.43206730 |
| 55 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.41362159 |
| 56 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.40344631 |
| 57 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.37710721 |
| 58 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.36870878 |
| 59 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.36140431 |
| 60 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.35627838 |
| 61 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.33080362 |
| 62 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.32670289 |
| 63 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.31073445 |
| 64 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.29769101 |
| 65 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.29050917 |
| 66 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.26969905 |
| 67 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.26969905 |
| 68 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.26478539 |
| 69 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.25684966 |
| 70 | AR_25329375_ChIP-Seq_VCAP_Human | 1.25307937 |
| 71 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.23819089 |
| 72 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.23163928 |
| 73 | STAT3_23295773_ChIP-Seq_U87_Human | 1.21690943 |
| 74 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.21169845 |
| 75 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.21035012 |
| 76 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.19479572 |
| 77 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.19042872 |
| 78 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.18793202 |
| 79 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.18679701 |
| 80 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.18627212 |
| 81 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.17471612 |
| 82 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.16074751 |
| 83 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.16052740 |
| 84 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.16052740 |
| 85 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.16031836 |
| 86 | FUS_26573619_Chip-Seq_HEK293_Human | 1.15782391 |
| 87 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.14182094 |
| 88 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.13446262 |
| 89 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.12506865 |
| 90 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.12371808 |
| 91 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.12076369 |
| 92 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.11792545 |
| 93 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.11492038 |
| 94 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.11188039 |
| 95 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.11013216 |
| 96 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.10731059 |
| 97 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10731059 |
| 98 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.10326637 |
| 99 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.08876104 |
| 100 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.08225876 |
| 101 | AR_19668381_ChIP-Seq_PC3_Human | 1.08214593 |
| 102 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06685421 |
| 103 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.05826143 |
| 104 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.05712665 |
| 105 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.04029232 |
| 106 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.03147333 |
| 107 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.02917581 |
| 108 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.02538045 |
| 109 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.01437251 |
| 110 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.01195508 |
| 111 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.99862537 |
| 112 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.99861657 |
| 113 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.99196327 |
| 114 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.98794502 |
| 115 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.98363613 |
| 116 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.97592829 |
| 117 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.97037471 |
| 118 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.95297757 |
| 119 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.94258328 |
| 120 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.93706478 |
| 121 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.93556992 |
| 122 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.92202406 |
| 123 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.91766575 |
| 124 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91690692 |
| 125 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.91541039 |
| 126 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.91541039 |
| 127 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.91411035 |
| 128 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.91155618 |
| 129 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.88927199 |
| 130 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.87996709 |
| 131 | TBL1_22424771_ChIP-Seq_293T_Human | 0.87453910 |
| 132 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.86662705 |
| 133 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.84812466 |
| 134 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.84788635 |
| 135 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.83163196 |
| 136 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.82241619 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 4.83893402 |
| 2 | MP0003646_muscle_fatigue | 4.10156496 |
| 3 | MP0000751_myopathy | 3.39124807 |
| 4 | MP0000749_muscle_degeneration | 3.17441348 |
| 5 | MP0004270_analgesia | 2.98054849 |
| 6 | MP0004145_abnormal_muscle_electrophysio | 2.86958679 |
| 7 | MP0004859_abnormal_synaptic_plasticity | 2.82937358 |
| 8 | MP0003880_abnormal_central_pattern | 2.79084986 |
| 9 | MP0004215_abnormal_myocardial_fiber | 2.74327203 |
| 10 | MP0004036_abnormal_muscle_relaxation | 2.66723968 |
| 11 | MP0003635_abnormal_synaptic_transmissio | 2.21904696 |
| 12 | MP0004084_abnormal_cardiac_muscle | 2.20377039 |
| 13 | MP0009745_abnormal_behavioral_response | 2.19288880 |
| 14 | MP0009046_muscle_twitch | 2.16227909 |
| 15 | MP0002272_abnormal_nervous_system | 2.12843843 |
| 16 | MP0001968_abnormal_touch/_nociception | 2.07360181 |
| 17 | MP0001529_abnormal_vocalization | 2.05761701 |
| 18 | MP0005409_darkened_coat_color | 2.05523647 |
| 19 | MP0002064_seizures | 2.05153411 |
| 20 | MP0004147_increased_porphyrin_level | 2.00600299 |
| 21 | MP0000747_muscle_weakness | 1.99130038 |
| 22 | MP0005330_cardiomyopathy | 1.97551548 |
| 23 | MP0002734_abnormal_mechanical_nocicepti | 1.94443900 |
| 24 | MP0005620_abnormal_muscle_contractility | 1.93385332 |
| 25 | MP0002106_abnormal_muscle_physiology | 1.90266584 |
| 26 | MP0002736_abnormal_nociception_after | 1.83929374 |
| 27 | MP0004484_altered_response_of | 1.82524988 |
| 28 | MP0003137_abnormal_impulse_conducting | 1.79852205 |
| 29 | MP0001486_abnormal_startle_reflex | 1.79048200 |
| 30 | MP0002735_abnormal_chemical_nociception | 1.75182084 |
| 31 | MP0002063_abnormal_learning/memory/cond | 1.74370998 |
| 32 | MP0001905_abnormal_dopamine_level | 1.72426441 |
| 33 | MP0004142_abnormal_muscle_tone | 1.69532715 |
| 34 | MP0001188_hyperpigmentation | 1.69081208 |
| 35 | MP0002972_abnormal_cardiac_muscle | 1.67789019 |
| 36 | MP0010630_abnormal_cardiac_muscle | 1.66748614 |
| 37 | MP0004130_abnormal_muscle_cell | 1.64589668 |
| 38 | MP0001986_abnormal_taste_sensitivity | 1.62181977 |
| 39 | MP0002269_muscular_atrophy | 1.61005227 |
| 40 | MP0002572_abnormal_emotion/affect_behav | 1.60932239 |
| 41 | MP0002127_abnormal_cardiovascular_syste | 1.60353683 |
| 42 | MP0005369_muscle_phenotype | 1.60012942 |
| 43 | MP0002822_catalepsy | 1.55713870 |
| 44 | MP0002108_abnormal_muscle_morphology | 1.54984014 |
| 45 | MP0004087_abnormal_muscle_fiber | 1.53449452 |
| 46 | MP0005423_abnormal_somatic_nervous | 1.53364356 |
| 47 | MP0004085_abnormal_heartbeat | 1.50788946 |
| 48 | MP0001984_abnormal_olfaction | 1.49747300 |
| 49 | MP0006036_abnormal_mitochondrial_physio | 1.49119890 |
| 50 | MP0002067_abnormal_sensory_capabilities | 1.48588511 |
| 51 | MP0004043_abnormal_pH_regulation | 1.47172997 |
| 52 | MP0001501_abnormal_sleep_pattern | 1.45247710 |
| 53 | MP0001970_abnormal_pain_threshold | 1.44886932 |
| 54 | MP0005646_abnormal_pituitary_gland | 1.44879855 |
| 55 | MP0005171_absent_coat_pigmentation | 1.41039663 |
| 56 | MP0005670_abnormal_white_adipose | 1.39086323 |
| 57 | MP0006276_abnormal_autonomic_nervous | 1.38054615 |
| 58 | MP0005386_behavior/neurological_phenoty | 1.37740235 |
| 59 | MP0004924_abnormal_behavior | 1.37740235 |
| 60 | MP0000920_abnormal_myelination | 1.37366479 |
| 61 | MP0000759_abnormal_skeletal_muscle | 1.37018709 |
| 62 | MP0001440_abnormal_grooming_behavior | 1.35745029 |
| 63 | MP0010386_abnormal_urinary_bladder | 1.32648900 |
| 64 | MP0008569_lethality_at_weaning | 1.29462429 |
| 65 | MP0005551_abnormal_eye_electrophysiolog | 1.24407539 |
| 66 | MP0002638_abnormal_pupillary_reflex | 1.24124850 |
| 67 | MP0005645_abnormal_hypothalamus_physiol | 1.23601013 |
| 68 | MP0006035_abnormal_mitochondrial_morpho | 1.20597787 |
| 69 | MP0002733_abnormal_thermal_nociception | 1.19220223 |
| 70 | MP0008775_abnormal_heart_ventricle | 1.18354622 |
| 71 | MP0002160_abnormal_reproductive_system | 1.11403631 |
| 72 | MP0003950_abnormal_plasma_membrane | 1.10834967 |
| 73 | MP0004510_myositis | 1.10394691 |
| 74 | MP0005451_abnormal_body_composition | 1.10045515 |
| 75 | MP0005385_cardiovascular_system_phenoty | 1.08829208 |
| 76 | MP0001544_abnormal_cardiovascular_syste | 1.08829208 |
| 77 | MP0002184_abnormal_innervation | 1.05879928 |
| 78 | MP0002229_neurodegeneration | 1.03521192 |
| 79 | MP0003828_pulmonary_edema | 1.03085538 |
| 80 | MP0003633_abnormal_nervous_system | 1.02488883 |
| 81 | MP0002066_abnormal_motor_capabilities/c | 1.00692166 |
| 82 | MP0004742_abnormal_vestibular_system | 0.99038240 |
| 83 | MP0001727_abnormal_embryo_implantation | 0.98860069 |
| 84 | MP0005266_abnormal_metabolism | 0.98613871 |
| 85 | MP0001502_abnormal_circadian_rhythm | 0.94345139 |
| 86 | MP0002557_abnormal_social/conspecific_i | 0.93767448 |
| 87 | MP0005535_abnormal_body_temperature | 0.93715989 |
| 88 | MP0003221_abnormal_cardiomyocyte_apopto | 0.93331952 |
| 89 | MP0004233_abnormal_muscle_weight | 0.92224008 |
| 90 | MP0002332_abnormal_exercise_endurance | 0.92114425 |
| 91 | MP0002102_abnormal_ear_morphology | 0.90195347 |
| 92 | MP0002882_abnormal_neuron_morphology | 0.89842179 |
| 93 | MP0001661_extended_life_span | 0.89071987 |
| 94 | MP0000013_abnormal_adipose_tissue | 0.88718639 |
| 95 | MP0003787_abnormal_imprinting | 0.87640444 |
| 96 | MP0003631_nervous_system_phenotype | 0.86685337 |
| 97 | MP0006072_abnormal_retinal_apoptosis | 0.85849593 |
| 98 | MP0000750_abnormal_muscle_regeneration | 0.85463374 |
| 99 | MP0002909_abnormal_adrenal_gland | 0.83926711 |
| 100 | MP0000778_abnormal_nervous_system | 0.83846482 |
| 101 | MP0001346_abnormal_lacrimal_gland | 0.82516968 |
| 102 | MP0001485_abnormal_pinna_reflex | 0.81463735 |
| 103 | MP0006138_congestive_heart_failure | 0.80359517 |
| 104 | MP0005253_abnormal_eye_physiology | 0.77158525 |
| 105 | MP0003329_amyloid_beta_deposits | 0.76954259 |
| 106 | MP0008877_abnormal_DNA_methylation | 0.76933181 |
| 107 | MP0000230_abnormal_systemic_arterial | 0.76722867 |
| 108 | MP0003567_abnormal_fetal_cardiomyocyte | 0.76660681 |
| 109 | MP0003123_paternal_imprinting | 0.75834850 |
| 110 | MP0000955_abnormal_spinal_cord | 0.74844629 |
| 111 | MP0009780_abnormal_chondrocyte_physiolo | 0.73867871 |
| 112 | MP0002876_abnormal_thyroid_physiology | 0.73553904 |
| 113 | MP0001963_abnormal_hearing_physiology | 0.71958043 |
| 114 | MP0002752_abnormal_somatic_nervous | 0.70970012 |
| 115 | MP0000015_abnormal_ear_pigmentation | 0.70634365 |
| 116 | MP0001299_abnormal_eye_distance/ | 0.70605622 |
| 117 | MP0003195_calcinosis | 0.70097500 |
| 118 | MP0000733_abnormal_muscle_development | 0.69697099 |
| 119 | MP0008260_abnormal_autophagy | 0.68516952 |
| 120 | MP0000372_irregular_coat_pigmentation | 0.67863670 |
| 121 | MP0000266_abnormal_heart_morphology | 0.65474623 |
| 122 | MP0003136_yellow_coat_color | 0.60541810 |
| 123 | MP0002971_abnormal_brown_adipose | 0.60408208 |
| 124 | MP0000003_abnormal_adipose_tissue | 0.58254429 |
| 125 | MP0003045_fibrosis | 0.56705640 |
| 126 | MP0005375_adipose_tissue_phenotype | 0.51041767 |
| 127 | MP0003890_abnormal_embryonic-extraembry | 0.50721488 |
| 128 | MP0001919_abnormal_reproductive_system | 0.50614405 |
| 129 | MP0005666_abnormal_adipose_tissue | 0.50418048 |
| 130 | MP0004811_abnormal_neuron_physiology | 0.50081929 |
| 131 | MP0004885_abnormal_endolymph | 0.49246332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 5.60903879 |
| 2 | Muscle hypertrophy of the lower extremities (HP:0008968) | 5.45797191 |
| 3 | Calf muscle hypertrophy (HP:0008981) | 5.36598589 |
| 4 | Focal motor seizures (HP:0011153) | 4.75921988 |
| 5 | Sudden death (HP:0001699) | 4.60160254 |
| 6 | Myopathic facies (HP:0002058) | 4.52036606 |
| 7 | Rimmed vacuoles (HP:0003805) | 4.36348026 |
| 8 | Exercise-induced muscle cramps (HP:0003710) | 4.34893126 |
| 9 | Abnormality of the calf musculature (HP:0001430) | 4.01541054 |
| 10 | Muscle fiber splitting (HP:0003555) | 3.99225363 |
| 11 | Acute necrotizing encephalopathy (HP:0006965) | 3.97969305 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.96681288 |
| 13 | Hyporeflexia of lower limbs (HP:0002600) | 3.93202248 |
| 14 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.89041192 |
| 15 | Frequent falls (HP:0002359) | 3.69942978 |
| 16 | Muscle fiber inclusion bodies (HP:0100299) | 3.66080267 |
| 17 | EMG: neuropathic changes (HP:0003445) | 3.62692061 |
| 18 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.59973867 |
| 19 | Pheochromocytoma (HP:0002666) | 3.54423927 |
| 20 | Neuroendocrine neoplasm (HP:0100634) | 3.43102938 |
| 21 | Atrial fibrillation (HP:0005110) | 3.42281771 |
| 22 | Myoglobinuria (HP:0002913) | 3.40414069 |
| 23 | Nemaline bodies (HP:0003798) | 3.37727625 |
| 24 | Acute encephalopathy (HP:0006846) | 3.34398525 |
| 25 | Progressive macrocephaly (HP:0004481) | 3.32955553 |
| 26 | Mitochondrial inheritance (HP:0001427) | 3.29146347 |
| 27 | Febrile seizures (HP:0002373) | 3.27895475 |
| 28 | EMG: myopathic abnormalities (HP:0003458) | 3.26900938 |
| 29 | Prolonged QT interval (HP:0001657) | 3.17759225 |
| 30 | Primary atrial arrhythmia (HP:0001692) | 3.15261808 |
| 31 | Myotonia (HP:0002486) | 3.14413779 |
| 32 | Syncope (HP:0001279) | 3.06900531 |
| 33 | Myokymia (HP:0002411) | 3.03445523 |
| 34 | Atonic seizures (HP:0010819) | 3.01860419 |
| 35 | Hepatocellular necrosis (HP:0001404) | 3.00831205 |
| 36 | Ventricular tachycardia (HP:0004756) | 2.99824344 |
| 37 | Supraventricular tachycardia (HP:0004755) | 2.99551086 |
| 38 | Hepatic necrosis (HP:0002605) | 2.98165920 |
| 39 | Bundle branch block (HP:0011710) | 2.96006636 |
| 40 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.89593587 |
| 41 | Supraventricular arrhythmia (HP:0005115) | 2.86092114 |
| 42 | Increased CSF lactate (HP:0002490) | 2.81865196 |
| 43 | Round ear (HP:0100830) | 2.78433059 |
| 44 | Palpitations (HP:0001962) | 2.78120415 |
| 45 | Epileptic encephalopathy (HP:0200134) | 2.63573428 |
| 46 | Generalized muscle weakness (HP:0003324) | 2.62092836 |
| 47 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.62016613 |
| 48 | Abnormality of alanine metabolism (HP:0010916) | 2.62016613 |
| 49 | Hyperalaninemia (HP:0003348) | 2.62016613 |
| 50 | Calcaneovalgus deformity (HP:0001848) | 2.61480243 |
| 51 | Right ventricular cardiomyopathy (HP:0011663) | 2.61158384 |
| 52 | Increased variability in muscle fiber diameter (HP:0003557) | 2.60976852 |
| 53 | Visual hallucinations (HP:0002367) | 2.60663556 |
| 54 | Central scotoma (HP:0000603) | 2.60105012 |
| 55 | Muscle stiffness (HP:0003552) | 2.55386536 |
| 56 | Left ventricular hypertrophy (HP:0001712) | 2.54911636 |
| 57 | Ulnar deviation of the wrist (HP:0003049) | 2.54303334 |
| 58 | Dilated cardiomyopathy (HP:0001644) | 2.53535613 |
| 59 | Focal seizures (HP:0007359) | 2.52520267 |
| 60 | Scapular winging (HP:0003691) | 2.44680484 |
| 61 | Exercise intolerance (HP:0003546) | 2.44265378 |
| 62 | Increased intramyocellular lipid droplets (HP:0012240) | 2.44147530 |
| 63 | Abnormal EKG (HP:0003115) | 2.44034770 |
| 64 | Muscular dystrophy (HP:0003560) | 2.43813242 |
| 65 | Optic disc pallor (HP:0000543) | 2.43743000 |
| 66 | Lipoatrophy (HP:0100578) | 2.43112175 |
| 67 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.42872590 |
| 68 | Difficulty running (HP:0009046) | 2.41895374 |
| 69 | Proximal amyotrophy (HP:0007126) | 2.40043645 |
| 70 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.37854047 |
| 71 | Subaortic stenosis (HP:0001682) | 2.37854047 |
| 72 | Absence seizures (HP:0002121) | 2.36412427 |
| 73 | Heart block (HP:0012722) | 2.34755639 |
| 74 | Generalized tonic-clonic seizures (HP:0002069) | 2.32844937 |
| 75 | Distal lower limb muscle weakness (HP:0009053) | 2.32762714 |
| 76 | Lactic acidosis (HP:0003128) | 2.31082470 |
| 77 | Absent phalangeal crease (HP:0006109) | 2.30364169 |
| 78 | Cerebral edema (HP:0002181) | 2.30095147 |
| 79 | Asymmetric septal hypertrophy (HP:0001670) | 2.29726310 |
| 80 | Abnormality of glycolysis (HP:0004366) | 2.28803351 |
| 81 | Increased serum pyruvate (HP:0003542) | 2.28803351 |
| 82 | Areflexia of lower limbs (HP:0002522) | 2.27382582 |
| 83 | Broad-based gait (HP:0002136) | 2.27032238 |
| 84 | Deformed tarsal bones (HP:0008119) | 2.25331496 |
| 85 | Hyperventilation (HP:0002883) | 2.24177451 |
| 86 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.24080300 |
| 87 | Limb-girdle muscle atrophy (HP:0003797) | 2.23962218 |
| 88 | Increased muscle lipid content (HP:0009058) | 2.23514984 |
| 89 | Rhabdomyolysis (HP:0003201) | 2.20128929 |
| 90 | Respiratory failure (HP:0002878) | 2.18858382 |
| 91 | Neck muscle weakness (HP:0000467) | 2.18468967 |
| 92 | Weak cry (HP:0001612) | 2.16568164 |
| 93 | Abnormal atrioventricular conduction (HP:0005150) | 2.13166127 |
| 94 | Dialeptic seizures (HP:0011146) | 2.13052984 |
| 95 | Anxiety (HP:0000739) | 2.08477168 |
| 96 | Ventricular fibrillation (HP:0001663) | 2.05407462 |
| 97 | Progressive muscle weakness (HP:0003323) | 2.03942690 |
| 98 | Methylmalonic acidemia (HP:0002912) | 2.01829168 |
| 99 | Progressive cerebellar ataxia (HP:0002073) | 2.00914051 |
| 100 | Difficulty climbing stairs (HP:0003551) | 2.00744351 |
| 101 | Ventricular arrhythmia (HP:0004308) | 1.99910951 |
| 102 | Progressive inability to walk (HP:0002505) | 1.99892550 |
| 103 | Increased hepatocellular lipid droplets (HP:0006565) | 1.98739359 |
| 104 | Abnormal finger flexion creases (HP:0006143) | 1.98187549 |
| 105 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.95122125 |
| 106 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.95122125 |
| 107 | Leukodystrophy (HP:0002415) | 1.95020590 |
| 108 | Gowers sign (HP:0003391) | 1.94752757 |
| 109 | Lipid accumulation in hepatocytes (HP:0006561) | 1.94482629 |
| 110 | Tinnitus (HP:0000360) | 1.93624022 |
| 111 | Increased connective tissue (HP:0009025) | 1.89483437 |
| 112 | Hyperkalemia (HP:0002153) | 1.88242205 |
| 113 | Distal arthrogryposis (HP:0005684) | 1.87967625 |
| 114 | Foot dorsiflexor weakness (HP:0009027) | 1.87658377 |
| 115 | Steppage gait (HP:0003376) | 1.87426270 |
| 116 | Renal Fanconi syndrome (HP:0001994) | 1.86346249 |
| 117 | Waddling gait (HP:0002515) | 1.85091413 |
| 118 | Bulbar palsy (HP:0001283) | 1.84081639 |
| 119 | Cerebral hemorrhage (HP:0001342) | 1.82871805 |
| 120 | Ragged-red muscle fibers (HP:0003200) | 1.81653353 |
| 121 | Retinal dysplasia (HP:0007973) | 1.81148654 |
| 122 | Fetal akinesia sequence (HP:0001989) | 1.80904677 |
| 123 | Sensory axonal neuropathy (HP:0003390) | 1.80841016 |
| 124 | Distal lower limb amyotrophy (HP:0008944) | 1.80763860 |
| 125 | Abnormal hair whorl (HP:0010721) | 1.80592605 |
| 126 | Atrioventricular block (HP:0001678) | 1.79689123 |
| 127 | Abnormality of the foot musculature (HP:0001436) | 1.79407447 |
| 128 | Type 1 muscle fiber predominance (HP:0003803) | 1.75609948 |
| 129 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.75398401 |
| 130 | Malignant hyperthermia (HP:0002047) | 1.73592792 |
| 131 | Poor eye contact (HP:0000817) | 1.73495116 |
| 132 | Hip contracture (HP:0003273) | 1.65167100 |
| 133 | Oligomenorrhea (HP:0000876) | 1.62248089 |
| 134 | Limb-girdle muscle weakness (HP:0003325) | 1.59036281 |
| 135 | Shoulder girdle muscle weakness (HP:0003547) | 1.58372480 |
| 136 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.57866824 |
| 137 | Abnormal social behavior (HP:0012433) | 1.56295633 |
| 138 | Impaired social interactions (HP:0000735) | 1.56295633 |
| 139 | Abnormality of the labia minora (HP:0012880) | 1.55796056 |
| 140 | Type II lissencephaly (HP:0007260) | 1.55647853 |
| 141 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.53144544 |
| 142 | Pachygyria (HP:0001302) | 1.51506482 |
| 143 | Long clavicles (HP:0000890) | 1.50458918 |
| 144 | Lower limb amyotrophy (HP:0007210) | 1.49888771 |
| 145 | Resting tremor (HP:0002322) | 1.48361927 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PHKG2 | 3.35520986 |
| 2 | PHKG1 | 3.35520986 |
| 3 | OBSCN | 3.13921024 |
| 4 | PNCK | 2.90910390 |
| 5 | TTN | 2.60685944 |
| 6 | CASK | 2.46405718 |
| 7 | MUSK | 2.16372416 |
| 8 | EPHA4 | 2.15064347 |
| 9 | NTRK3 | 2.13684260 |
| 10 | STK39 | 2.04091161 |
| 11 | NLK | 1.92160948 |
| 12 | GRK7 | 1.90865136 |
| 13 | STK16 | 1.88494756 |
| 14 | INSRR | 1.88275521 |
| 15 | MAP2K7 | 1.84601655 |
| 16 | PDK3 | 1.81874320 |
| 17 | PDK4 | 1.81874320 |
| 18 | PINK1 | 1.78740240 |
| 19 | PIK3CG | 1.71408068 |
| 20 | NME1 | 1.68169884 |
| 21 | TNIK | 1.61573408 |
| 22 | OXSR1 | 1.61503664 |
| 23 | MYLK | 1.61493797 |
| 24 | MAP3K4 | 1.55107784 |
| 25 | WNK4 | 1.54823808 |
| 26 | LMTK2 | 1.49242135 |
| 27 | PIK3CA | 1.44170118 |
| 28 | CAMK2D | 1.40731584 |
| 29 | EPHA3 | 1.40127360 |
| 30 | SIK3 | 1.39394374 |
| 31 | SGK494 | 1.36448816 |
| 32 | SGK223 | 1.36448816 |
| 33 | CDK9 | 1.35026252 |
| 34 | MARK1 | 1.32677280 |
| 35 | BMPR2 | 1.30855604 |
| 36 | MAP3K12 | 1.29461063 |
| 37 | PRPF4B | 1.25382783 |
| 38 | PKN1 | 1.24903886 |
| 39 | PLK2 | 1.22539300 |
| 40 | CAMK2A | 1.21381699 |
| 41 | MAP3K9 | 1.18865534 |
| 42 | WNK1 | 1.17108555 |
| 43 | TIE1 | 1.14003789 |
| 44 | CAMK2B | 1.13546113 |
| 45 | ZAK | 1.13009304 |
| 46 | CAMK2G | 1.09421726 |
| 47 | BCKDK | 1.07742248 |
| 48 | MAP2K4 | 1.07087494 |
| 49 | GRK5 | 1.06170248 |
| 50 | BCR | 1.04477975 |
| 51 | MARK3 | 1.04406605 |
| 52 | PAK3 | 1.03450731 |
| 53 | PRKCE | 1.01022922 |
| 54 | SGK2 | 1.00586038 |
| 55 | MAPK12 | 0.99650579 |
| 56 | PBK | 0.98231369 |
| 57 | PDK2 | 0.96777376 |
| 58 | CAMK1G | 0.95742649 |
| 59 | PRKAA1 | 0.95606685 |
| 60 | CAMK4 | 0.94429821 |
| 61 | DAPK2 | 0.93498629 |
| 62 | DMPK | 0.91807457 |
| 63 | ARAF | 0.90885366 |
| 64 | MINK1 | 0.90805861 |
| 65 | EPHB1 | 0.90581194 |
| 66 | BRAF | 0.88696096 |
| 67 | WNK3 | 0.87595875 |
| 68 | RIPK4 | 0.87512129 |
| 69 | CDK19 | 0.84446255 |
| 70 | SIK2 | 0.83723402 |
| 71 | CDK5 | 0.83308391 |
| 72 | MAPK13 | 0.82977527 |
| 73 | NEK6 | 0.82601178 |
| 74 | UHMK1 | 0.81866180 |
| 75 | ADRBK2 | 0.81348759 |
| 76 | NTRK2 | 0.80029943 |
| 77 | MAPKAPK5 | 0.79451972 |
| 78 | DYRK2 | 0.77692368 |
| 79 | PRKAA2 | 0.75370847 |
| 80 | TXK | 0.70960178 |
| 81 | EEF2K | 0.70207794 |
| 82 | ROCK2 | 0.69168014 |
| 83 | STK38L | 0.68990460 |
| 84 | GRK1 | 0.68854926 |
| 85 | PAK6 | 0.67365678 |
| 86 | TTK | 0.66803580 |
| 87 | CSNK1A1L | 0.65885750 |
| 88 | PRKCQ | 0.64283640 |
| 89 | SGK1 | 0.63418999 |
| 90 | LIMK1 | 0.63046648 |
| 91 | CAMK1 | 0.62774793 |
| 92 | CSNK1G3 | 0.62465156 |
| 93 | WEE1 | 0.62392374 |
| 94 | PRKACA | 0.62273368 |
| 95 | MAP4K2 | 0.62261525 |
| 96 | TNK2 | 0.62107595 |
| 97 | SGK3 | 0.61671747 |
| 98 | MAP2K3 | 0.60924895 |
| 99 | STK11 | 0.60425790 |
| 100 | PRKCG | 0.59464247 |
| 101 | MAP3K6 | 0.58828950 |
| 102 | PRKG1 | 0.57166002 |
| 103 | BMPR1B | 0.57107574 |
| 104 | CDC42BPA | 0.55862557 |
| 105 | IRAK4 | 0.55108090 |
| 106 | PRKCH | 0.54973101 |
| 107 | CSNK1G2 | 0.54896376 |
| 108 | CCNB1 | 0.54294043 |
| 109 | PRKD1 | 0.53396794 |
| 110 | STK24 | 0.52574387 |
| 111 | PDPK1 | 0.52457184 |
| 112 | DYRK1B | 0.49893926 |
| 113 | NTRK1 | 0.48644326 |
| 114 | MAPK10 | 0.48572126 |
| 115 | PRKACB | 0.47113856 |
| 116 | CDC7 | 0.46643309 |
| 117 | FRK | 0.45749405 |
| 118 | AKT3 | 0.45715307 |
| 119 | MAP2K6 | 0.45172011 |
| 120 | CAMKK2 | 0.43819549 |
| 121 | MAPK7 | 0.43815253 |
| 122 | RPS6KB1 | 0.43482916 |
| 123 | IRAK2 | 0.43087534 |
| 124 | MAPK11 | 0.42961450 |
| 125 | MAP3K7 | 0.42865246 |
| 126 | PDK1 | 0.42789957 |
| 127 | DYRK1A | 0.42596929 |
| 128 | NEK1 | 0.42088384 |
| 129 | ERBB3 | 0.41411524 |
| 130 | ROCK1 | 0.41240201 |
| 131 | CAMK1D | 0.41175469 |
| 132 | TYRO3 | 0.40172541 |
| 133 | MAPKAPK3 | 0.39719154 |
| 134 | MAP3K5 | 0.39214687 |
| 135 | RPS6KA1 | 0.38978482 |
| 136 | PRKD3 | 0.38857652 |
| 137 | RPS6KA3 | 0.37412766 |
| 138 | PLK4 | 0.35562009 |
| 139 | ICK | 0.35128292 |
| 140 | MARK2 | 0.32851670 |
| 141 | TRPM7 | 0.30075750 |
| 142 | RPS6KA6 | 0.30015201 |
| 143 | KSR1 | 0.30014886 |
| 144 | ZAP70 | 0.28209650 |
| 145 | MAPK15 | 0.27578220 |
| 146 | MAPK8 | 0.26458855 |
| 147 | AKT2 | 0.25343623 |
| 148 | CSNK1E | 0.25087468 |
| 149 | GSK3B | 0.22746423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.69562958 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 3.15819801 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.98823334 |
| 4 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.95238506 |
| 5 | Alzheimers disease_Homo sapiens_hsa05010 | 2.71159850 |
| 6 | Nicotine addiction_Homo sapiens_hsa05033 | 2.53988409 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.16321322 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.09726072 |
| 9 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.09450365 |
| 10 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.99717784 |
| 11 | Circadian entrainment_Homo sapiens_hsa04713 | 1.99675511 |
| 12 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.99370671 |
| 13 | Olfactory transduction_Homo sapiens_hsa04740 | 1.97706570 |
| 14 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.90321749 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.87004149 |
| 16 | GABAergic synapse_Homo sapiens_hsa04727 | 1.85448158 |
| 17 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.78845440 |
| 18 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.74072217 |
| 19 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.72539334 |
| 20 | Taste transduction_Homo sapiens_hsa04742 | 1.72244494 |
| 21 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.71623792 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.70345505 |
| 23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.70224122 |
| 24 | Insulin secretion_Homo sapiens_hsa04911 | 1.69304561 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.65956547 |
| 26 | Phototransduction_Homo sapiens_hsa04744 | 1.58834954 |
| 27 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.50256803 |
| 28 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.45578463 |
| 29 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.43622640 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40851408 |
| 31 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.39709169 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.38418251 |
| 33 | Long-term potentiation_Homo sapiens_hsa04720 | 1.36817533 |
| 34 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.35797562 |
| 35 | Salivary secretion_Homo sapiens_hsa04970 | 1.34686073 |
| 36 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.30205298 |
| 37 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.27226432 |
| 38 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.26327140 |
| 39 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.25155963 |
| 40 | Renin secretion_Homo sapiens_hsa04924 | 1.24393825 |
| 41 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.24115228 |
| 42 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.20340630 |
| 43 | Long-term depression_Homo sapiens_hsa04730 | 1.20151921 |
| 44 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.18161072 |
| 45 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.08485334 |
| 46 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.07595191 |
| 47 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.06274523 |
| 48 | Lysine degradation_Homo sapiens_hsa00310 | 1.06230846 |
| 49 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.04636756 |
| 50 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.02696279 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.02389245 |
| 52 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.01136680 |
| 53 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00628869 |
| 54 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.98870810 |
| 55 | Insulin resistance_Homo sapiens_hsa04931 | 0.98782555 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.98179277 |
| 57 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.96313167 |
| 58 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.94837315 |
| 59 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.93063183 |
| 60 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.92984212 |
| 61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.90626788 |
| 62 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.87491040 |
| 63 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.87045631 |
| 64 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.85947332 |
| 65 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.82936511 |
| 66 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.82354345 |
| 67 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.80837180 |
| 68 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.79362562 |
| 69 | Cocaine addiction_Homo sapiens_hsa05030 | 0.78955918 |
| 70 | RNA degradation_Homo sapiens_hsa03018 | 0.78886439 |
| 71 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.77231986 |
| 72 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.77034724 |
| 73 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.76375559 |
| 74 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.75556485 |
| 75 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.75210627 |
| 76 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.74884520 |
| 77 | Tight junction_Homo sapiens_hsa04530 | 0.73145445 |
| 78 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.70655778 |
| 79 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.70293041 |
| 80 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.69415380 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.68211315 |
| 82 | Carbon metabolism_Homo sapiens_hsa01200 | 0.66494778 |
| 83 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.66278462 |
| 84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.66035033 |
| 85 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.65930462 |
| 86 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.61834735 |
| 87 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.61510139 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59288686 |
| 89 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.58417546 |
| 90 | Gap junction_Homo sapiens_hsa04540 | 0.56426252 |
| 91 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.55544304 |
| 92 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.55006715 |
| 93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.54880778 |
| 94 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.54448016 |
| 95 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.52529924 |
| 96 | Axon guidance_Homo sapiens_hsa04360 | 0.49040555 |
| 97 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.48417680 |
| 98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.48156307 |
| 99 | Peroxisome_Homo sapiens_hsa04146 | 0.47848596 |
| 100 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.47778834 |
| 101 | Endometrial cancer_Homo sapiens_hsa05213 | 0.47743963 |
| 102 | Purine metabolism_Homo sapiens_hsa00230 | 0.45753259 |
| 103 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.45171211 |
| 104 | Basal transcription factors_Homo sapiens_hsa03022 | 0.43976883 |
| 105 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.43213469 |
| 106 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.42119854 |
| 107 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.41810916 |
| 108 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.40294432 |
| 109 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.40238245 |
| 110 | Protein export_Homo sapiens_hsa03060 | 0.39280345 |
| 111 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.38633853 |
| 112 | Mineral absorption_Homo sapiens_hsa04978 | 0.38406697 |
| 113 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.38086126 |
| 114 | ABC transporters_Homo sapiens_hsa02010 | 0.37694448 |
| 115 | Metabolic pathways_Homo sapiens_hsa01100 | 0.37605183 |
| 116 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.37584603 |
| 117 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.36706592 |
| 118 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.36495957 |
| 119 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.36330347 |
| 120 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.35619666 |
| 121 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.35184392 |
| 122 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.33904825 |
| 123 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.29500853 |
| 124 | Phagosome_Homo sapiens_hsa04145 | 0.28378517 |
| 125 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.28136258 |
| 126 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.27223982 |
| 127 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.27124753 |
| 128 | Viral myocarditis_Homo sapiens_hsa05416 | 0.26561241 |
| 129 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.26168274 |
| 130 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.25591459 |
| 131 | Melanogenesis_Homo sapiens_hsa04916 | 0.25165593 |
| 132 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.24756874 |
| 133 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.24557972 |
| 134 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.24461407 |

