DCUN1D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fat-soluble vitamin biosynthetic process (GO:0042362)8.70056172
2sulfation (GO:0051923)7.01515415
3regulation of glomerulus development (GO:0090192)6.47311733
4vitamin transmembrane transport (GO:0035461)6.47280040
5cellular response to ATP (GO:0071318)6.25292144
6regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.18843921
7response to pheromone (GO:0019236)5.84837519
8regulation of cell proliferation involved in kidney development (GO:1901722)5.76642008
9regulation of phospholipid biosynthetic process (GO:0071071)5.30532060
10vascular endothelial growth factor signaling pathway (GO:0038084)5.28503546
11positive regulation of dendritic spine morphogenesis (GO:0061003)5.22553093
12protein targeting to Golgi (GO:0000042)4.98240335
13low-density lipoprotein particle clearance (GO:0034383)4.94859105
14regulation of sequestering of triglyceride (GO:0010889)4.90275095
15negative regulation of systemic arterial blood pressure (GO:0003085)4.78911657
16monoubiquitinated protein deubiquitination (GO:0035520)4.78606804
17water-soluble vitamin biosynthetic process (GO:0042364)4.66202150
18indole-containing compound catabolic process (GO:0042436)4.57709254
19indolalkylamine catabolic process (GO:0046218)4.57709254
20tryptophan catabolic process (GO:0006569)4.57709254
21positive regulation of metanephros development (GO:0072216)4.55427494
22establishment of protein localization to Golgi (GO:0072600)4.52482539
23regulation of DNA endoreduplication (GO:0032875)4.50849473
24cell proliferation in forebrain (GO:0021846)4.50254415
25behavioral response to nicotine (GO:0035095)4.49077680
26regulation of establishment or maintenance of cell polarity (GO:0032878)4.43483337
27nuclear pore complex assembly (GO:0051292)4.42748481
28positive regulation of cAMP-mediated signaling (GO:0043950)4.42138616
29retrograde transport, vesicle recycling within Golgi (GO:0000301)4.40355619
30kynurenine metabolic process (GO:0070189)4.28228849
31negative regulation of platelet activation (GO:0010544)4.25916935
32epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.21106119
33dorsal/ventral axis specification (GO:0009950)4.19935274
34positive regulation of protein autophosphorylation (GO:0031954)4.16442385
35pharyngeal system development (GO:0060037)4.06377123
36heart trabecula formation (GO:0060347)4.03653939
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.89501177
38iron ion import (GO:0097286)3.86773920
39otic vesicle formation (GO:0030916)3.86356256
40flavonoid metabolic process (GO:0009812)3.86222408
413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.83420024
42purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.83420024
43negative regulation of endothelial cell apoptotic process (GO:2000352)3.81031540
44tryptophan metabolic process (GO:0006568)3.77839424
45negative regulation of cardiac muscle tissue development (GO:0055026)3.77167231
46positive regulation of fatty acid beta-oxidation (GO:0032000)3.73112899
47positive regulation of actin cytoskeleton reorganization (GO:2000251)3.71343635
48nuclear pore organization (GO:0006999)3.68868242
49regulation of posttranscriptional gene silencing (GO:0060147)3.65871058
50regulation of gene silencing by miRNA (GO:0060964)3.65871058
51regulation of gene silencing by RNA (GO:0060966)3.65871058
52positive regulation of focal adhesion assembly (GO:0051894)3.60649078
53positive regulation of cell junction assembly (GO:1901890)3.60649078
54indolalkylamine metabolic process (GO:0006586)3.59087532
55positive regulation of glomerulus development (GO:0090193)3.58822921
56opsonization (GO:0008228)3.57136629
57tooth mineralization (GO:0034505)3.56639567
58positive regulation of adherens junction organization (GO:1903393)3.51056544
59N-acetylglucosamine metabolic process (GO:0006044)3.49806740
60sprouting angiogenesis (GO:0002040)3.44156720
61positive regulation of cardiac muscle cell differentiation (GO:2000727)3.43975495
62regulation of metanephros development (GO:0072215)3.40732401
63quaternary ammonium group transport (GO:0015697)3.37545327
64negative chemotaxis (GO:0050919)3.35737592
65lymphangiogenesis (GO:0001946)3.34679334
66sperm motility (GO:0030317)3.34231287
67negative regulation of hormone biosynthetic process (GO:0032353)3.31958357
68negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.29951405
69regulation of hippo signaling (GO:0035330)3.29258309
70gamma-aminobutyric acid transport (GO:0015812)3.24580567
71plasma membrane repair (GO:0001778)3.22223853
72negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.19769208
73estrogen metabolic process (GO:0008210)3.17110246
74negative regulation of axon guidance (GO:1902668)3.16975271
75negative regulation of mast cell activation (GO:0033004)3.16580708
76N-terminal protein amino acid acetylation (GO:0006474)3.13610279
77trabecula formation (GO:0060343)3.11466529
78limb bud formation (GO:0060174)3.11181939
79negative regulation of response to food (GO:0032096)3.11036476
80negative regulation of appetite (GO:0032099)3.11036476
81histone H3-K9 demethylation (GO:0033169)3.10425852
82pore complex assembly (GO:0046931)3.10407038
83regulation of protein autophosphorylation (GO:0031952)3.10345185
84embryonic hindlimb morphogenesis (GO:0035116)3.10311098
85ear development (GO:0043583)3.09816602
86negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.08966135
87import into cell (GO:0098657)3.08005065
88macroautophagy (GO:0016236)3.07285798
89keratan sulfate biosynthetic process (GO:0018146)3.06322703
90negative regulation of transcription regulatory region DNA binding (GO:2000678)3.06167083
91regulation of endothelial cell apoptotic process (GO:2000351)3.01983782
92regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.01596819
93vitamin biosynthetic process (GO:0009110)3.00887912
94regulation of mesoderm development (GO:2000380)2.99900312
95negative regulation of nitric-oxide synthase activity (GO:0051001)2.98784923
96endothelial cell proliferation (GO:0001935)2.97119236
97DNA deamination (GO:0045006)2.96920738
98negative regulation of inclusion body assembly (GO:0090084)2.96186613
99regulation of vascular permeability (GO:0043114)2.94568407
100artery development (GO:0060840)2.94546741
101regulation of RNA export from nucleus (GO:0046831)2.94408723
102cellular anion homeostasis (GO:0030002)2.94369798
103negative regulation by host of viral transcription (GO:0043922)2.93627540
104fusion of sperm to egg plasma membrane (GO:0007342)2.92622378
105negative regulation of fibrinolysis (GO:0051918)2.92324285
106regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.90633894
107negative regulation of protein autophosphorylation (GO:0031953)2.90439803
108indole-containing compound metabolic process (GO:0042430)2.90320594
109regulation of podosome assembly (GO:0071801)2.89456340
110positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.88084041
111smooth muscle tissue development (GO:0048745)2.82746448
112regulation of protein polyubiquitination (GO:1902914)2.82265547
113negative regulation of vascular permeability (GO:0043116)2.81027572
114protein polyglutamylation (GO:0018095)2.80937114
115modified amino acid transport (GO:0072337)2.79739543
116positive regulation of p38MAPK cascade (GO:1900745)2.78160638
117negative regulation of hormone metabolic process (GO:0032351)2.76748263
118positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.75769221
119protein localization to endosome (GO:0036010)2.74152378
120vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73686993
121lung morphogenesis (GO:0060425)2.73183075
122musculoskeletal movement (GO:0050881)2.72880701
123multicellular organismal movement (GO:0050879)2.72880701
124positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72397899
125positive regulation of fatty acid oxidation (GO:0046321)2.72326075
126cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.72035569
127response to ATP (GO:0033198)2.71283360
128cellular response to exogenous dsRNA (GO:0071360)2.71233398
129definitive hemopoiesis (GO:0060216)2.70942755
130amine catabolic process (GO:0009310)2.70343431
131cellular biogenic amine catabolic process (GO:0042402)2.70343431
132regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.70152768
133positive regulation of cellular amide metabolic process (GO:0034250)2.69457168
134regulation of germinal center formation (GO:0002634)2.68073047
135S-adenosylmethionine metabolic process (GO:0046500)2.67192054
136organ induction (GO:0001759)2.66246054
137positive regulation of lipid kinase activity (GO:0090218)2.63491973
138hippo signaling (GO:0035329)2.63338063
139regulation of collateral sprouting (GO:0048670)2.62592460
140keratan sulfate metabolic process (GO:0042339)2.62438486
141angiogenesis involved in wound healing (GO:0060055)2.60817025
142positive regulation of lipid storage (GO:0010884)2.60128440
143establishment of endothelial barrier (GO:0061028)2.59951491
144negative regulation of blood pressure (GO:0045776)2.59153962
145head development (GO:0060322)2.58999273
146positive regulation of glycolytic process (GO:0045821)2.58650312
147fatty acid transmembrane transport (GO:1902001)2.58220028
148retina vasculature morphogenesis in camera-type eye (GO:0061299)2.56402796
149somite development (GO:0061053)2.56307668
150mitotic sister chromatid cohesion (GO:0007064)2.55845915
151mesonephros development (GO:0001823)2.54456480
152positive regulation of hormone biosynthetic process (GO:0046886)2.53980040
153acrosome assembly (GO:0001675)2.53608570
154carnitine shuttle (GO:0006853)2.52308341
155peptidyl-tyrosine autophosphorylation (GO:0038083)2.50925710
156reflex (GO:0060004)2.50798183
157carnitine transmembrane transport (GO:1902603)2.49322794
158regulation of cholesterol homeostasis (GO:2000188)2.48420847
159lung vasculature development (GO:0060426)2.48128010
160secondary heart field specification (GO:0003139)2.46790958
161heart field specification (GO:0003128)2.46790958
162regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.46667055
163insulin-like growth factor receptor signaling pathway (GO:0048009)2.46371430
164regulation of cholesterol storage (GO:0010885)2.46100984
165prostate gland growth (GO:0060736)2.46073155
166hindlimb morphogenesis (GO:0035137)2.44494078
167serotonin metabolic process (GO:0042428)2.43409648
168cytoplasmic mRNA processing body assembly (GO:0033962)2.43012775
169branching involved in salivary gland morphogenesis (GO:0060445)2.41794835
170peristalsis (GO:0030432)2.41493058
171positive regulation of lipid catabolic process (GO:0050996)2.41028579
172regulation of dendritic spine morphogenesis (GO:0061001)2.40924901
173regulation of fatty acid beta-oxidation (GO:0031998)2.40327411
174amino-acid betaine transport (GO:0015838)2.40092529
175carnitine transport (GO:0015879)2.40092529
176negative regulation of receptor-mediated endocytosis (GO:0048261)2.37224526
177regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.35203949
178wound healing, spreading of epidermal cells (GO:0035313)2.33193437
179patterning of blood vessels (GO:0001569)2.31365842
180synaptonemal complex assembly (GO:0007130)2.30406961
181female genitalia development (GO:0030540)2.29629971
182protein localization to Golgi apparatus (GO:0034067)2.28997203
183piRNA metabolic process (GO:0034587)2.28897283
184peptidyl-threonine dephosphorylation (GO:0035970)2.28059215
185lung epithelium development (GO:0060428)2.27529078
186diaphragm development (GO:0060539)2.26833748
187regulation of protein import into nucleus, translocation (GO:0033158)2.26514877
188polyol transport (GO:0015791)2.24126423
189regulation of transforming growth factor beta2 production (GO:0032909)2.24072050
190negative regulation of lipid storage (GO:0010888)2.23752066
191regulation of nucleobase-containing compound transport (GO:0032239)2.22656222
192eyelid development in camera-type eye (GO:0061029)2.22561713
193cell wall macromolecule catabolic process (GO:0016998)2.21917727
194cell wall macromolecule metabolic process (GO:0044036)2.21917727
195anterior/posterior axis specification, embryo (GO:0008595)2.20232332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.05009391
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.00935893
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.30981399
4EZH2_22144423_ChIP-Seq_EOC_Human2.73513176
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62446874
6GBX2_23144817_ChIP-Seq_PC3_Human2.60778955
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45444621
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39278145
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.34177799
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25268021
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.22673040
12EWS_26573619_Chip-Seq_HEK293_Human2.09403305
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08360924
14CLOCK_20551151_ChIP-Seq_293T_Human2.03591631
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01169817
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97322037
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91651722
18IGF1R_20145208_ChIP-Seq_DFB_Human1.91633148
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.91388310
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89834813
21P300_19829295_ChIP-Seq_ESCs_Human1.89035071
22FUS_26573619_Chip-Seq_HEK293_Human1.88519313
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83336397
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81727256
25* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79249420
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.77410470
27ZNF274_21170338_ChIP-Seq_K562_Hela1.77325582
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76828091
29* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75311507
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.72199401
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.71670520
32BCAT_22108803_ChIP-Seq_LS180_Human1.70676758
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69420742
34ER_23166858_ChIP-Seq_MCF-7_Human1.68942103
35TP53_16413492_ChIP-PET_HCT116_Human1.66495889
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65212547
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64157416
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.63520534
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62005780
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60578111
41VDR_22108803_ChIP-Seq_LS180_Human1.59075297
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58977774
43CJUN_26792858_Chip-Seq_BT549_Human1.58867323
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58755508
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57980290
46CBP_20019798_ChIP-Seq_JUKART_Human1.57980290
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56021146
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54497868
49TAF15_26573619_Chip-Seq_HEK293_Human1.52235275
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48111414
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48023307
52PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.45668680
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.44803230
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.44628494
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44042200
56SMAD4_21799915_ChIP-Seq_A2780_Human1.43937184
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43315238
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43045448
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39175292
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38757069
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38715771
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38715771
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38527202
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37997770
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36854580
66* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.36602057
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.36106781
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36074940
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35777423
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34103853
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.34019000
72* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33771552
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32866862
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.31480150
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.30951033
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.30832291
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30485934
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.30274856
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29490611
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28835025
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27782104
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27414260
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.26758217
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25787721
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25787721
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.25297786
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.25054985
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24179015
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.23149680
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23149166
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22564928
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22190640
93* TP53_18474530_ChIP-ChIP_U2OS_Human1.20851995
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.20669902
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20336597
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20236207
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19887400
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19849185
99AHR_22903824_ChIP-Seq_MCF-7_Human1.19058018
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18555007
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16834611
102* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16412312
103AR_25329375_ChIP-Seq_VCAP_Human1.16408884
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16337874
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15998949
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.15551478
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.15534311
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13565030
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12748002
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12623582
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12295893
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11531193
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11527783
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11523716
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.11250870
116BRD4_25478319_ChIP-Seq_HGPS_Human1.10504725
117* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09844978
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09771398
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09628702
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.09503495
121TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09403516
122* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09254761
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08695927
124TCF4_22108803_ChIP-Seq_LS180_Human1.08442018
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08342949
126* KDM2B_26808549_Chip-Seq_REH_Human1.08062656
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07580616
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07474799
129* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07218178
130P53_22387025_ChIP-Seq_ESCs_Mouse1.07036238
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06615719
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06198269
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05836842
134IRF8_22096565_ChIP-ChIP_GC-B_Human1.05814937
135PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05262553
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.05209259
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04496630
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.04296356
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.04101318
140RXR_22158963_ChIP-Seq_LIVER_Mouse1.04050168
141ISL1_27105846_Chip-Seq_CPCs_Mouse1.03968872
142NANOG_19829295_ChIP-Seq_ESCs_Human1.02775883
143SOX2_19829295_ChIP-Seq_ESCs_Human1.02775883
144ARNT_22903824_ChIP-Seq_MCF-7_Human1.02427753
145STAT3_18555785_Chip-Seq_ESCs_Mouse1.02262590
146* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02195816
147FLI1_27457419_Chip-Seq_LIVER_Mouse1.01874959
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99815866
149RXR_22108803_ChIP-Seq_LS180_Human0.99167054
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98627897
151KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98309688
152KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98309688
153KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98309688
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98046513
155CDX2_22108803_ChIP-Seq_LS180_Human0.97444658
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96818383
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96279322
158STAT3_23295773_ChIP-Seq_U87_Human0.95055854
159* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92999037
160ESR1_21235772_ChIP-Seq_MCF-7_Human0.90304700
161TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90290629
162ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90162259
163JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89879107
164TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89502867
165FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89184023
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88778050
167P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88115430
168NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87117491
169TBL1_22424771_ChIP-Seq_293T_Human0.86824976
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85864305
171SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84979146
172FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84874858
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.84792336
174* TCF4_23295773_ChIP-Seq_U87_Human0.83316742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.16421541
2MP0003195_calcinosis5.07006724
3MP0004134_abnormal_chest_morphology3.80655865
4MP0002138_abnormal_hepatobiliary_system3.62273741
5MP0005410_abnormal_fertilization3.22790490
6MP0003705_abnormal_hypodermis_morpholog3.12525665
7MP0005666_abnormal_adipose_tissue3.08795814
8MP0008438_abnormal_cutaneous_collagen3.01434045
9MP0004185_abnormal_adipocyte_glucose2.99137918
10MP0006138_congestive_heart_failure2.87766381
11MP0002160_abnormal_reproductive_system2.72170407
12MP0003646_muscle_fatigue2.59820336
13MP0003828_pulmonary_edema2.52548531
14MP0006292_abnormal_olfactory_placode2.47710764
15MP0005646_abnormal_pituitary_gland2.43567833
16MP0005275_abnormal_skin_tensile2.38983182
17MP0003950_abnormal_plasma_membrane2.38348433
18MP0005076_abnormal_cell_differentiation2.38073387
19MP0004145_abnormal_muscle_electrophysio2.35988631
20MP0009250_abnormal_appendicular_skeleto2.29014938
21MP0002254_reproductive_system_inflammat2.20623955
22MP0002876_abnormal_thyroid_physiology2.15606754
23MP0005375_adipose_tissue_phenotype2.15056876
24MP0002796_impaired_skin_barrier2.14747484
25MP0009278_abnormal_bone_marrow2.13016890
26MP0000049_abnormal_middle_ear2.12985334
27MP0003091_abnormal_cell_migration2.11463337
28MP0001485_abnormal_pinna_reflex2.11427371
29MP0004130_abnormal_muscle_cell2.09426716
30MP0001542_abnormal_bone_strength2.03998779
31MP0002108_abnormal_muscle_morphology2.03668909
32MP0005389_reproductive_system_phenotype2.02918801
33MP0009780_abnormal_chondrocyte_physiolo1.94684882
34MP0002877_abnormal_melanocyte_morpholog1.92930131
35MP0005167_abnormal_blood-brain_barrier1.87865362
36MP0000631_abnormal_neuroendocrine_gland1.87585544
37MP0005623_abnormal_meninges_morphology1.86645214
38MP0008872_abnormal_physiological_respon1.83478705
39MP0010234_abnormal_vibrissa_follicle1.80655639
40MP0003724_increased_susceptibility_to1.79951953
41MP0004272_abnormal_basement_membrane1.78070836
42MP0002139_abnormal_hepatobiliary_system1.74866972
43MP0010352_gastrointestinal_tract_polyps1.72756075
44MP0004885_abnormal_endolymph1.71142562
45MP0001853_heart_inflammation1.68649473
46MP0002837_dystrophic_cardiac_calcinosis1.68598785
47MP0009053_abnormal_anal_canal1.68305952
48MP0002295_abnormal_pulmonary_circulatio1.67842599
49MP0000013_abnormal_adipose_tissue1.66937457
50MP0005257_abnormal_intraocular_pressure1.58364666
51MP0000678_abnormal_parathyroid_gland1.56315463
52MP0003011_delayed_dark_adaptation1.55483935
53MP0004019_abnormal_vitamin_homeostasis1.54356483
54MP0002282_abnormal_trachea_morphology1.48751515
55MP0005084_abnormal_gallbladder_morpholo1.47877410
56MP0006072_abnormal_retinal_apoptosis1.45280630
57MP0010307_abnormal_tumor_latency1.43915902
58MP0001440_abnormal_grooming_behavior1.43823083
59MP0003638_abnormal_response/metabolism_1.43548524
60MP0005365_abnormal_bile_salt1.41282851
61MP0009384_cardiac_valve_regurgitation1.41023152
62MP0003890_abnormal_embryonic-extraembry1.39765211
63MP0005551_abnormal_eye_electrophysiolog1.38732688
64MP0003566_abnormal_cell_adhesion1.38478267
65MP0000733_abnormal_muscle_development1.38422325
66MP0002148_abnormal_hypersensitivity_rea1.37872968
67MP0002277_abnormal_respiratory_mucosa1.36800063
68MP0010329_abnormal_lipoprotein_level1.32181216
69MP0009115_abnormal_fat_cell1.31758050
70MP0003567_abnormal_fetal_cardiomyocyte1.31386212
71MP0008961_abnormal_basal_metabolism1.31343986
72MP0003453_abnormal_keratinocyte_physiol1.31039530
73MP0002089_abnormal_postnatal_growth/wei1.30250692
74MP0003878_abnormal_ear_physiology1.29953273
75MP0005377_hearing/vestibular/ear_phenot1.29953273
76MP0003045_fibrosis1.26973373
77MP0002971_abnormal_brown_adipose1.26864434
78MP0000003_abnormal_adipose_tissue1.24172618
79MP0002163_abnormal_gland_morphology1.24006357
80MP0001299_abnormal_eye_distance/1.23290691
81MP0009785_altered_susceptibility_to1.21547920
82MP0003937_abnormal_limbs/digits/tail_de1.21154383
83MP0001879_abnormal_lymphatic_vessel1.21099930
84MP0002060_abnormal_skin_morphology1.20970134
85MP0003806_abnormal_nucleotide_metabolis1.20604735
86MP0000569_abnormal_digit_pigmentation1.19815477
87MP0003941_abnormal_skin_development1.19697998
88MP0003943_abnormal_hepatobiliary_system1.14559421
89MP0005379_endocrine/exocrine_gland_phen1.14315752
90MP0000516_abnormal_urinary_system1.14171898
91MP0005367_renal/urinary_system_phenotyp1.14171898
92MP0010630_abnormal_cardiac_muscle1.12972291
93MP0004484_altered_response_of1.11746736
94MP0002735_abnormal_chemical_nociception1.10638952
95MP0005595_abnormal_vascular_smooth1.10015033
96MP0005448_abnormal_energy_balance1.09721139
97MP0004142_abnormal_muscle_tone1.09036538
98MP0002734_abnormal_mechanical_nocicepti1.08536042
99MP0003942_abnormal_urinary_system1.07425938
100MP0000230_abnormal_systemic_arterial1.07424792
101MP0004215_abnormal_myocardial_fiber1.06529517
102MP0009764_decreased_sensitivity_to1.06278682
103MP0000767_abnormal_smooth_muscle1.05863317
104MP0003448_altered_tumor_morphology1.05791633
105MP0010386_abnormal_urinary_bladder1.05730185
106MP0002925_abnormal_cardiovascular_devel1.05035352
107MP0004133_heterotaxia1.04609467
108MP0003300_gastrointestinal_ulcer1.04115890
109MP0001661_extended_life_span1.03043965
110MP0002697_abnormal_eye_size1.01244459
111MP0000163_abnormal_cartilage_morphology1.01166844
112MP0000383_abnormal_hair_follicle1.00962682
113MP0002009_preneoplasia1.00403242
114MP0009703_decreased_birth_body0.99739974
115MP0003698_abnormal_male_reproductive0.99696549
116MP0002086_abnormal_extraembryonic_tissu0.99352601
117MP0002118_abnormal_lipid_homeostasis0.98438544
118MP0001915_intracranial_hemorrhage0.97806152
119MP0001756_abnormal_urination0.96938438
120MP0005385_cardiovascular_system_phenoty0.96715868
121MP0001544_abnormal_cardiovascular_syste0.96715868
122MP0002102_abnormal_ear_morphology0.95963662
123MP0002928_abnormal_bile_duct0.95373960
124MP0005023_abnormal_wound_healing0.95215629
125MP0002733_abnormal_thermal_nociception0.94418849
126MP0005334_abnormal_fat_pad0.92338520
127MP0008877_abnormal_DNA_methylation0.91963194
128MP0001177_atelectasis0.91761456
129MP0000613_abnormal_salivary_gland0.91530776
130MP0010368_abnormal_lymphatic_system0.91372189
131MP0005360_urolithiasis0.88729899
132MP0009672_abnormal_birth_weight0.88709668
133MP0001919_abnormal_reproductive_system0.88638772
134MP0002088_abnormal_embryonic_growth/wei0.88059951
135MP0005248_abnormal_Harderian_gland0.86303168
136MP0002896_abnormal_bone_mineralization0.86191754
137MP0002168_other_aberrant_phenotype0.85903016
138MP0002006_tumorigenesis0.85716870
139MP0002272_abnormal_nervous_system0.85710997
140MP0001968_abnormal_touch/_nociception0.84689780
141MP0005380_embryogenesis_phenotype0.84393672
142MP0001672_abnormal_embryogenesis/_devel0.84393672
143MP0001784_abnormal_fluid_regulation0.81686642
144MP0008007_abnormal_cellular_replicative0.80767902
145MP0000428_abnormal_craniofacial_morphol0.79885817
146MP0000467_abnormal_esophagus_morphology0.79793798
147MP0001730_embryonic_growth_arrest0.79535027
148MP0003115_abnormal_respiratory_system0.79497648
149MP0000627_abnormal_mammary_gland0.78617859
150MP0009765_abnormal_xenobiotic_induced0.78567898
151MP0001970_abnormal_pain_threshold0.78525027
152MP0005253_abnormal_eye_physiology0.78332852
153MP0009046_muscle_twitch0.78299147
154MP0003984_embryonic_growth_retardation0.78237235
155MP0003935_abnormal_craniofacial_develop0.77627904
156MP0000750_abnormal_muscle_regeneration0.76765285
157MP0003936_abnormal_reproductive_system0.76705213
158MP0005083_abnormal_biliary_tract0.75601590
159MP0002133_abnormal_respiratory_system0.75386721
160MP0005388_respiratory_system_phenotype0.75386721
161MP0001614_abnormal_blood_vessel0.75054810
162MP0005508_abnormal_skeleton_morphology0.75004632
163MP0005671_abnormal_response_to0.74813507
164MP0003252_abnormal_bile_duct0.74747037
165MP0005647_abnormal_sex_gland0.74689071
166MP0005501_abnormal_skin_physiology0.73795454
167MP0010678_abnormal_skin_adnexa0.73705436
168MP0005503_abnormal_tendon_morphology0.72587309
169MP0004197_abnormal_fetal_growth/weight/0.72401118
170MP0001216_abnormal_epidermal_layer0.71175495
171MP0000579_abnormal_nail_morphology0.70704396
172MP0005195_abnormal_posterior_eye0.70428791
173MP0002084_abnormal_developmental_patter0.69897189
174MP0000427_abnormal_hair_cycle0.69739775
175MP0003755_abnormal_palate_morphology0.69127281
176MP0002115_abnormal_skeleton_extremities0.68213040
177MP0005390_skeleton_phenotype0.65558268
178MP0002109_abnormal_limb_morphology0.64976687
179MP0002135_abnormal_kidney_morphology0.64349480
180MP0008875_abnormal_xenobiotic_pharmacok0.63455676
181MP0003938_abnormal_ear_development0.59608344

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.37057353
2Pendular nystagmus (HP:0012043)4.93205696
3Hypoglycemic seizures (HP:0002173)4.50170340
4Symptomatic seizures (HP:0011145)4.43431867
5Genetic anticipation (HP:0003743)4.39376901
6Porencephaly (HP:0002132)4.04983068
7Abolished electroretinogram (ERG) (HP:0000550)4.00717386
8Conjunctival hamartoma (HP:0100780)3.95204032
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.78256673
10Pancreatic cysts (HP:0001737)3.77911568
11Pancreatic fibrosis (HP:0100732)3.73222081
12Insulin-resistant diabetes mellitus (HP:0000831)3.67287625
13Premature rupture of membranes (HP:0001788)3.66291129
14Increased CSF protein (HP:0002922)3.60605332
15Keratoconus (HP:0000563)3.55019161
16Increased corneal curvature (HP:0100692)3.55019161
17Methylmalonic acidemia (HP:0002912)3.52243013
18True hermaphroditism (HP:0010459)3.52213614
19Severe visual impairment (HP:0001141)3.47596736
20Confusion (HP:0001289)3.45367247
21Septo-optic dysplasia (HP:0100842)3.39498610
22Furrowed tongue (HP:0000221)3.36281754
23Abnormality of the proximal phalanges of the hand (HP:0009834)3.30826680
24Hamartoma of the eye (HP:0010568)3.29526175
25Decreased central vision (HP:0007663)3.26629725
26Agitation (HP:0000713)3.22182063
27Progressive cerebellar ataxia (HP:0002073)3.21282397
28Hypoglycemic coma (HP:0001325)3.19311306
29Abnormality of the phalanges of the 2nd finger (HP:0009541)3.16604070
30Acanthosis nigricans (HP:0000956)3.11904758
31Congenital, generalized hypertrichosis (HP:0004540)3.11549441
32Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.10211151
33Tetany (HP:0001281)2.98753162
34Asplenia (HP:0001746)2.94215304
35Short hallux (HP:0010109)2.89121617
36Abnormality of the nasal septum (HP:0000419)2.88606258
37Hypoplastic pelvis (HP:0008839)2.87606308
38Abnormal rod and cone electroretinograms (HP:0008323)2.87204923
39Congenital sensorineural hearing impairment (HP:0008527)2.84062159
40Bone cyst (HP:0012062)2.84030197
41Hyperglycemia (HP:0003074)2.83794609
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.78399731
43Methylmalonic aciduria (HP:0012120)2.73150801
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.72569072
45Aplasia/Hypoplasia of the hallux (HP:0008362)2.72059565
46Myocardial infarction (HP:0001658)2.71977278
47Glucose intolerance (HP:0000833)2.71733749
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.69816047
49Short tibia (HP:0005736)2.67395287
50Hyporeflexia of lower limbs (HP:0002600)2.65393293
51Abnormal pancreas size (HP:0012094)2.65149829
523-Methylglutaconic aciduria (HP:0003535)2.62601140
53Abnormality of the middle phalanges of the toes (HP:0010183)2.62031854
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60405068
55Pancreatic islet-cell hyperplasia (HP:0004510)2.60132046
56Chorioretinal atrophy (HP:0000533)2.58972430
57Oral leukoplakia (HP:0002745)2.58348563
58Hand muscle atrophy (HP:0009130)2.56412046
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.54802040
60Short 1st metacarpal (HP:0010034)2.54802040
61Abnormality of the axillary hair (HP:0100134)2.50262037
62Abnormality of secondary sexual hair (HP:0009888)2.50262037
63Long foot (HP:0001833)2.49675824
64Mesomelia (HP:0003027)2.48341373
65Homocystinuria (HP:0002156)2.46768742
66Abnormality of homocysteine metabolism (HP:0010919)2.46768742
67Absent hand (HP:0004050)2.45931207
68Spinal rigidity (HP:0003306)2.45287760
69Morphological abnormality of the middle ear (HP:0008609)2.41462130
70Meningioma (HP:0002858)2.38379800
71Small hand (HP:0200055)2.36131944
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.35618466
73Cone-rod dystrophy (HP:0000548)2.32824691
74Gaze-evoked nystagmus (HP:0000640)2.32688258
75Goiter (HP:0000853)2.31617972
76Shallow orbits (HP:0000586)2.31242390
77Nephronophthisis (HP:0000090)2.31049404
78Short humerus (HP:0005792)2.29471656
79Epidermoid cyst (HP:0200040)2.29381184
80Pigmentary retinal degeneration (HP:0001146)2.29153131
81Wrist flexion contracture (HP:0001239)2.28947581
82Short femoral neck (HP:0100864)2.28939461
83Submucous cleft hard palate (HP:0000176)2.27786851
84Insulin resistance (HP:0000855)2.24450156
85Cystic liver disease (HP:0006706)2.23763000
86Increased connective tissue (HP:0009025)2.23042089
87Attenuation of retinal blood vessels (HP:0007843)2.22781489
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22643638
89Annular pancreas (HP:0001734)2.21795045
90Gonadotropin excess (HP:0000837)2.20501388
91Long nose (HP:0003189)2.18488336
92Abnormality of the 1st metacarpal (HP:0010009)2.17883837
93Hemiplegia (HP:0002301)2.15056041
94Ectopic kidney (HP:0000086)2.14181627
95Congenital stationary night blindness (HP:0007642)2.12552971
96Upper limb amyotrophy (HP:0009129)2.12284070
97Distal upper limb amyotrophy (HP:0007149)2.12284070
98Autoimmune thrombocytopenia (HP:0001973)2.11363240
99Abnormality of midbrain morphology (HP:0002418)2.10997836
100Molar tooth sign on MRI (HP:0002419)2.10997836
101Dynein arm defect of respiratory motile cilia (HP:0012255)2.08426017
102Absent/shortened dynein arms (HP:0200106)2.08426017
103Thyroiditis (HP:0100646)2.07510788
104Difficulty running (HP:0009046)2.07224019
105Abnormality of the renal collecting system (HP:0004742)2.06941716
106Basal ganglia calcification (HP:0002135)2.06616498
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.05780660
108Aplasia/hypoplasia of the humerus (HP:0006507)2.05513237
109Abnormality of methionine metabolism (HP:0010901)2.04996436
110Adactyly (HP:0009776)2.04858963
111Short 4th metacarpal (HP:0010044)2.04857514
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04857514
113Muscle fiber splitting (HP:0003555)2.03211499
114Visual hallucinations (HP:0002367)2.02153470
115Abnormality of the hepatic vasculature (HP:0006707)2.01999949
116Abnormality of DNA repair (HP:0003254)2.00446800
117Upper limb muscle weakness (HP:0003484)2.00419490
118Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.00179268
119Optic nerve hypoplasia (HP:0000609)1.99689463
120Male infertility (HP:0003251)1.96893579
121Turricephaly (HP:0000262)1.96791999
122Hematochezia (HP:0002573)1.96431861
123Sclerocornea (HP:0000647)1.95618897
124Radial bowing (HP:0002986)1.95498081
125Fused cervical vertebrae (HP:0002949)1.95385236
126Absent eyebrow (HP:0002223)1.95080802
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94803950
128Hypoplastic labia majora (HP:0000059)1.94646973
129Mitral valve prolapse (HP:0001634)1.92996999
130Venous insufficiency (HP:0005293)1.92969059
131Hyperglycinuria (HP:0003108)1.92962484
132Male pseudohermaphroditism (HP:0000037)1.92248695
133Cerebral aneurysm (HP:0004944)1.91383381
134Tetraparesis (HP:0002273)1.91262928
135Abnormal glucose tolerance (HP:0001952)1.90749723
136Intellectual disability, profound (HP:0002187)1.90596914
137Short phalanx of the thumb (HP:0009660)1.89991673
138Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.89786248
139Skin nodule (HP:0200036)1.89015777
140Venous abnormality (HP:0002624)1.88998935
141Stenosis of the external auditory canal (HP:0000402)1.88947656
142Natal tooth (HP:0000695)1.88612150
143Abnormality of the labia (HP:0000058)1.88394058
144Short palpebral fissure (HP:0012745)1.88393887
145Protrusio acetabuli (HP:0003179)1.88328322
146Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.88293299
147Focal segmental glomerulosclerosis (HP:0000097)1.88131691
148Abnormality of the renal medulla (HP:0100957)1.88019365
149Abnormality of ocular smooth pursuit (HP:0000617)1.87137939
150Advanced eruption of teeth (HP:0006288)1.86877494
151Oligomenorrhea (HP:0000876)1.86834032
152Birth length less than 3rd percentile (HP:0003561)1.86347983
153Hypoplastic ischia (HP:0003175)1.86202329
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86006764
155Anencephaly (HP:0002323)1.85798435
156Transitional cell carcinoma of the bladder (HP:0006740)1.85077464
157Esophageal varix (HP:0002040)1.84701176
158Complete atrioventricular canal defect (HP:0001674)1.84681535
159Atrophic scars (HP:0001075)1.83327774
160Abnormality of the renal cortex (HP:0011035)1.82874760
161Synostosis of carpal bones (HP:0005048)1.82096797
162Bronchomalacia (HP:0002780)1.80730105
163Prominent nose (HP:0000448)1.80304704
164Abnormality of the 2nd finger (HP:0004100)1.79988435
165Impaired smooth pursuit (HP:0007772)1.79800094
166Persistence of primary teeth (HP:0006335)1.78531040
167Abnormality of the labia majora (HP:0012881)1.78398265
168Hemiparesis (HP:0001269)1.77846178
169Uterine leiomyosarcoma (HP:0002891)1.76492436
170Leiomyosarcoma (HP:0100243)1.76492436
171Narrow palate (HP:0000189)1.76405402
172Abnormality of chromosome stability (HP:0003220)1.76347412
173Bladder neoplasm (HP:0009725)1.75722894
174Bladder carcinoma (HP:0002862)1.75722894
175Hypoalphalipoproteinemia (HP:0003233)1.75117678
176Type I diabetes mellitus (HP:0100651)1.69670286
177Abnormality of the ischium (HP:0003174)1.69303044
178Delayed puberty (HP:0000823)1.68940495
179Portal hypertension (HP:0001409)1.67244100
180Thick nail (HP:0001805)1.67239081
181Abnormality of the intrinsic pathway (HP:0010989)1.66038128
182Xanthomatosis (HP:0000991)1.65219404
183Hypomagnesemia (HP:0002917)1.64928465
184Abnormality of the labia minora (HP:0012880)1.64048929
185Bicornuate uterus (HP:0000813)1.62757845
186Enlarged penis (HP:0000040)1.61587468
187Progressive external ophthalmoplegia (HP:0000590)1.58873204
188Abnormality of the aortic arch (HP:0012303)1.58646330
189Conjunctival telangiectasia (HP:0000524)1.58416599
190Microretrognathia (HP:0000308)1.58206841
191Fibular aplasia (HP:0002990)1.57063080
192Hemorrhage of the eye (HP:0011885)1.55248952
193Peritonitis (HP:0002586)1.54850901
194Hypoplasia of the uterus (HP:0000013)1.54652266
195Abnormality of endocrine pancreas physiology (HP:0012093)1.54252935
196Abnormality of the pancreatic islet cells (HP:0006476)1.54252935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.30722545
2CAMK1D4.18036687
3CAMK1G3.38015246
4GRK13.03427779
5BMX2.92422309
6ACVR1B2.33628501
7TAF12.29214738
8MST42.24959815
9INSRR2.24156312
10NUAK12.17258874
11TEC2.14071824
12BMPR1B2.08578392
13AKT32.06884627
14MAP4K22.01549711
15LATS12.01532219
16TIE111.7250353
17GRK71.96122458
18TNIK1.91067628
19CDK121.87384453
20MAP3K121.78109309
21TAOK31.61945993
22PDK41.51237714
23PDK31.51237714
24ICK1.51223088
25STK241.49863448
26TLK11.49588939
27PRKD31.48311199
28FRK1.45243797
29ZAK1.42961088
30TXK1.40799169
31BLK1.38408566
32LATS21.34761494
33VRK21.32991831
34IKBKB1.32862651
35TSSK61.26658697
36EIF2AK31.25386761
37TGFBR21.15261205
38STK161.10391956
39MUSK1.10286513
40SGK21.09455273
41FLT31.05679872
42ADRBK11.05621791
43CSNK1G11.04062222
44BRSK21.03852539
45SIK11.03811796
46PDK21.03084928
47MTOR1.00720782
48VRK11.00425586
49MYLK0.99583753
50SGK30.94727625
51DYRK1B0.92891551
52SGK4940.90946180
53SGK2230.90946180
54CLK10.89933587
55ABL20.88681109
56PNCK0.88138646
57STK30.84311991
58ERBB40.84114391
59MET0.82606924
60FGFR20.82246393
61PLK20.77775157
62PRKAA20.75573934
63MAP3K20.75170303
64CHUK0.72286204
65DDR20.70805717
66DAPK20.70492457
67EPHA20.69903222
68EPHA30.69612949
69CSNK1A1L0.66085356
70MKNK20.64182064
71PRKAA10.64070982
72WNK30.64069966
73CSNK1G20.63607881
74OXSR10.63358124
75PDGFRA0.61964940
76FER0.61853139
77CSNK1G30.60856344
78STK380.60600336
79ERBB30.59631573
80MAPKAPK50.59585580
81PBK0.59232640
82CDK60.59082777
83GRK50.58973152
84JAK10.57519577
85NLK0.57147044
86PAK30.56983533
87PDPK10.56788968
88CSNK1A10.56268911
89MAP3K90.56250566
90TTN0.55908074
91PRKCE0.52592148
92TYRO30.50240843
93MAPK70.48207189
94PDGFRB0.45995732
95PINK10.45481124
96GSK3A0.44944698
97BRD40.44569272
98INSR0.44529845
99NTRK10.44302512
100WNK10.44076473
101TRPM70.43821645
102PTK2B0.43560025
103MELK0.42855599
104GRK60.42754815
105NME10.42296479
106ERBB20.41963871
107KSR20.41829748
108PAK60.41529714
109MAPK100.40823044
110PRKD10.39873446
111TRIB30.39675807
112FGFR30.39639683
113MAPKAPK30.39314893
114MAP2K20.38889105
115IKBKE0.38437352
116RPS6KA50.37904965
117MAP2K10.37566475
118PRKD20.37486740
119PRKACA0.37427085
120STK38L0.37051734
121WNK40.35765214
122MAPK40.35116452
123PKN10.34813675
124EGFR0.34739776
125HIPK20.34736594
126MST1R0.34494974
127PIK3CA0.34434872
128CAMK2A0.33276426
129SGK10.33206052
130TTK0.33025831
131PRKCH0.32671416
132PRKCI0.32255502
133CASK0.32067556
134DAPK30.31297719
135PIM10.31217446
136PRKCA0.31030492
137PRKCG0.30900778
138ALK0.30573452
139MAP3K30.29884837
140DYRK30.29638596
141IGF1R0.29603323
142MAPK130.28765487
143EPHB10.28220894
144CSK0.27774866
145NEK20.27496747
146CSNK1E0.27083873
147STK390.26557560
148MARK20.26408024
149PLK30.26003907
150PTK20.25352588
151DYRK20.24974554
152MAP3K40.24928335
153FGFR40.24009284
154MAPK80.22937661
155MAPK10.21366841
156ABL10.19929992
157PDK10.19773073
158MAPK90.19139979
159NEK90.19002618
160TYK20.17504980
161CDK90.17186730
162RET0.16338648
163EIF2AK20.15386548

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.69404333
2Vitamin B6 metabolism_Homo sapiens_hsa007503.46738546
3PPAR signaling pathway_Homo sapiens_hsa033203.01997868
4Sulfur metabolism_Homo sapiens_hsa009202.50479639
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28952558
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.21928455
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.15410366
8Phototransduction_Homo sapiens_hsa047442.14213072
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08597385
10Homologous recombination_Homo sapiens_hsa034401.99413635
11Rheumatoid arthritis_Homo sapiens_hsa053231.94760989
12Chemical carcinogenesis_Homo sapiens_hsa052041.91195488
13Dorso-ventral axis formation_Homo sapiens_hsa043201.89050164
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.85992835
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.85588299
16Fatty acid biosynthesis_Homo sapiens_hsa000611.81243683
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81045030
18HIF-1 signaling pathway_Homo sapiens_hsa040661.69649618
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66698769
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66381188
21Oxidative phosphorylation_Homo sapiens_hsa001901.63556060
22Adherens junction_Homo sapiens_hsa045201.61535697
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.61474069
24Fructose and mannose metabolism_Homo sapiens_hsa000511.57610616
25Protein export_Homo sapiens_hsa030601.55699780
26Basal transcription factors_Homo sapiens_hsa030221.53479062
27AMPK signaling pathway_Homo sapiens_hsa041521.50255401
28Glucagon signaling pathway_Homo sapiens_hsa049221.44288610
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44053829
30Retinol metabolism_Homo sapiens_hsa008301.43629347
31Bile secretion_Homo sapiens_hsa049761.41980214
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.41811148
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.38125660
34Renal cell carcinoma_Homo sapiens_hsa052111.37763543
35Caffeine metabolism_Homo sapiens_hsa002321.36717536
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36390904
37Nitrogen metabolism_Homo sapiens_hsa009101.34119608
38Insulin resistance_Homo sapiens_hsa049311.32803799
39Nicotine addiction_Homo sapiens_hsa050331.31504526
40Systemic lupus erythematosus_Homo sapiens_hsa053221.30508568
41Type II diabetes mellitus_Homo sapiens_hsa049301.28890130
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28646674
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22153040
44RNA polymerase_Homo sapiens_hsa030201.19687752
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.18115728
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17819864
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.17707100
48Estrogen signaling pathway_Homo sapiens_hsa049151.17214347
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15746983
50mTOR signaling pathway_Homo sapiens_hsa041501.15320737
51Asthma_Homo sapiens_hsa053101.13604211
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12720858
53TGF-beta signaling pathway_Homo sapiens_hsa043501.10634408
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06552509
55Fatty acid metabolism_Homo sapiens_hsa012121.04480536
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.04230434
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04207276
58Propanoate metabolism_Homo sapiens_hsa006401.03804354
59Prostate cancer_Homo sapiens_hsa052151.03010512
60Sphingolipid metabolism_Homo sapiens_hsa006001.02584396
61Glycerolipid metabolism_Homo sapiens_hsa005611.02300502
62Butanoate metabolism_Homo sapiens_hsa006501.02235600
63Insulin signaling pathway_Homo sapiens_hsa049101.01288400
64Ovarian steroidogenesis_Homo sapiens_hsa049131.01044525
65Taste transduction_Homo sapiens_hsa047420.99992655
66Morphine addiction_Homo sapiens_hsa050320.98474257
67MicroRNAs in cancer_Homo sapiens_hsa052060.97448971
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96698582
69FoxO signaling pathway_Homo sapiens_hsa040680.95706981
70Linoleic acid metabolism_Homo sapiens_hsa005910.93800087
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93657728
72Parkinsons disease_Homo sapiens_hsa050120.93153812
73Hematopoietic cell lineage_Homo sapiens_hsa046400.92739146
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.88079990
75Proteoglycans in cancer_Homo sapiens_hsa052050.87145853
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84317003
77RNA degradation_Homo sapiens_hsa030180.83616642
78Alzheimers disease_Homo sapiens_hsa050100.81201295
79Hippo signaling pathway_Homo sapiens_hsa043900.79724673
80Serotonergic synapse_Homo sapiens_hsa047260.79714764
81Focal adhesion_Homo sapiens_hsa045100.79250843
82Rap1 signaling pathway_Homo sapiens_hsa040150.79078370
83ECM-receptor interaction_Homo sapiens_hsa045120.77755578
84Basal cell carcinoma_Homo sapiens_hsa052170.76353497
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75190259
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74597239
87Fatty acid degradation_Homo sapiens_hsa000710.74395828
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.72875393
89Melanogenesis_Homo sapiens_hsa049160.72610042
90Renin-angiotensin system_Homo sapiens_hsa046140.71611288
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71017440
92Lysine degradation_Homo sapiens_hsa003100.70722849
93Selenocompound metabolism_Homo sapiens_hsa004500.69817562
94Choline metabolism in cancer_Homo sapiens_hsa052310.69581211
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68165020
96Insulin secretion_Homo sapiens_hsa049110.67790385
97Glutamatergic synapse_Homo sapiens_hsa047240.67451617
98Amoebiasis_Homo sapiens_hsa051460.67433967
99ABC transporters_Homo sapiens_hsa020100.66177166
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65672267
101Circadian rhythm_Homo sapiens_hsa047100.65592130
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.65530161
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65135062
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64516380
105MAPK signaling pathway_Homo sapiens_hsa040100.63500725
106Bladder cancer_Homo sapiens_hsa052190.63419694
107ErbB signaling pathway_Homo sapiens_hsa040120.63224170
108Renin secretion_Homo sapiens_hsa049240.62119740
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61708958
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61679008
111Small cell lung cancer_Homo sapiens_hsa052220.60053195
112Ras signaling pathway_Homo sapiens_hsa040140.59614489
113Graft-versus-host disease_Homo sapiens_hsa053320.59137072
114Thyroid hormone synthesis_Homo sapiens_hsa049180.59111859
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.59084081
116Phenylalanine metabolism_Homo sapiens_hsa003600.58907209
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58547334
118Endocytosis_Homo sapiens_hsa041440.58464208
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57061098
120Cardiac muscle contraction_Homo sapiens_hsa042600.57051618
121GnRH signaling pathway_Homo sapiens_hsa049120.56987010
122Arginine biosynthesis_Homo sapiens_hsa002200.56418699
123Tight junction_Homo sapiens_hsa045300.55979654
124Prion diseases_Homo sapiens_hsa050200.55913368
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55558141
126Staphylococcus aureus infection_Homo sapiens_hsa051500.55488612
127cAMP signaling pathway_Homo sapiens_hsa040240.54523291
128Inositol phosphate metabolism_Homo sapiens_hsa005620.54405080
129Mineral absorption_Homo sapiens_hsa049780.53816766
130Endometrial cancer_Homo sapiens_hsa052130.53751566
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53677951
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53207050
133Calcium signaling pathway_Homo sapiens_hsa040200.53077117
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52417965
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51653463
136Hedgehog signaling pathway_Homo sapiens_hsa043400.51329944
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51323494
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51013288
139Melanoma_Homo sapiens_hsa052180.50241073
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49330557
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49257667
142Oocyte meiosis_Homo sapiens_hsa041140.49059396
143TNF signaling pathway_Homo sapiens_hsa046680.49013296
144Huntingtons disease_Homo sapiens_hsa050160.48662174
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48600632
146Primary immunodeficiency_Homo sapiens_hsa053400.47783852
147African trypanosomiasis_Homo sapiens_hsa051430.46573499
148Hepatitis C_Homo sapiens_hsa051600.46280466
149Type I diabetes mellitus_Homo sapiens_hsa049400.46214165
150Complement and coagulation cascades_Homo sapiens_hsa046100.45150706
151Olfactory transduction_Homo sapiens_hsa047400.44801635
152Malaria_Homo sapiens_hsa051440.44225969
153Vitamin digestion and absorption_Homo sapiens_hsa049770.44203327
154p53 signaling pathway_Homo sapiens_hsa041150.43362387
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42660086
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41765366
157Glioma_Homo sapiens_hsa052140.41259120
158Wnt signaling pathway_Homo sapiens_hsa043100.40637844
159Gap junction_Homo sapiens_hsa045400.40565337
160Chronic myeloid leukemia_Homo sapiens_hsa052200.40475171
161Acute myeloid leukemia_Homo sapiens_hsa052210.39493232
162Fat digestion and absorption_Homo sapiens_hsa049750.39015499
163Dilated cardiomyopathy_Homo sapiens_hsa054140.38950875
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.38595146
165Tryptophan metabolism_Homo sapiens_hsa003800.38493924
166Phospholipase D signaling pathway_Homo sapiens_hsa040720.38385241
167Fanconi anemia pathway_Homo sapiens_hsa034600.38267838
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37908906
169Pathways in cancer_Homo sapiens_hsa052000.34953084

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