DCUN1D4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.08598421
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08140932
3synaptic vesicle exocytosis (GO:0016079)4.81888113
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63463150
5vocalization behavior (GO:0071625)4.52225529
6synaptic vesicle maturation (GO:0016188)4.46245863
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42787090
8neuron cell-cell adhesion (GO:0007158)4.42756740
9glutamate secretion (GO:0014047)4.38782971
10negative regulation of DNA-dependent DNA replication (GO:2000104)4.35361337
11locomotory exploration behavior (GO:0035641)4.31029974
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.23326874
13replication fork processing (GO:0031297)4.16024660
14protein localization to synapse (GO:0035418)4.15931715
15regulation of synaptic vesicle exocytosis (GO:2000300)4.13261033
16regulation of glutamate receptor signaling pathway (GO:1900449)4.01265199
17neurotransmitter secretion (GO:0007269)3.90309976
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.88198957
19neuronal action potential propagation (GO:0019227)3.84476406
20gamma-aminobutyric acid transport (GO:0015812)3.76308154
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.69546509
22regulation of neuronal synaptic plasticity (GO:0048168)3.67669594
23layer formation in cerebral cortex (GO:0021819)3.64812915
24exploration behavior (GO:0035640)3.63761416
25regulation of synaptic vesicle transport (GO:1902803)3.63059796
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.62731196
27neuron recognition (GO:0008038)3.62697081
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.60361790
29glutamate receptor signaling pathway (GO:0007215)3.59251083
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59109156
31dendritic spine morphogenesis (GO:0060997)3.58140255
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55684670
33neuron-neuron synaptic transmission (GO:0007270)3.53635350
34synaptic transmission, glutamatergic (GO:0035249)3.50897384
35DNA replication checkpoint (GO:0000076)3.46770359
36chromatin remodeling at centromere (GO:0031055)3.44163998
37neurotransmitter-gated ion channel clustering (GO:0072578)3.43477360
38histone exchange (GO:0043486)3.42836669
39lactate metabolic process (GO:0006089)3.37002932
40mitotic sister chromatid cohesion (GO:0007064)3.36551806
41transmission of nerve impulse (GO:0019226)3.34014286
42cullin deneddylation (GO:0010388)3.33354681
43DNA replication-dependent nucleosome organization (GO:0034723)3.33294864
44DNA replication-dependent nucleosome assembly (GO:0006335)3.33294864
45neurotransmitter transport (GO:0006836)3.33001674
46CENP-A containing nucleosome assembly (GO:0034080)3.30077050
47axonal fasciculation (GO:0007413)3.28420009
48presynaptic membrane assembly (GO:0097105)3.28249999
49kidney morphogenesis (GO:0060993)3.24713998
50histone H2A acetylation (GO:0043968)3.23968515
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.22367905
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21328323
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15361065
54regulation of dendritic spine morphogenesis (GO:0061001)3.13544919
55proteasome assembly (GO:0043248)3.13508206
56regulation of neurotransmitter levels (GO:0001505)3.12622260
57presynaptic membrane organization (GO:0097090)3.11432298
58limb bud formation (GO:0060174)3.11312939
59regulation of glucokinase activity (GO:0033131)3.10835259
60regulation of hexokinase activity (GO:1903299)3.10835259
61behavioral response to cocaine (GO:0048148)3.09073972
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08833828
63response to pheromone (GO:0019236)3.08375173
64long-term synaptic potentiation (GO:0060291)3.06816914
65regulation of postsynaptic membrane potential (GO:0060078)3.06442663
66neuromuscular process controlling posture (GO:0050884)3.06101169
67dendrite morphogenesis (GO:0048813)3.04606992
68regulation of synaptic plasticity (GO:0048167)3.03240938
69positive regulation of membrane potential (GO:0045838)3.02653208
70long-term memory (GO:0007616)3.01260513
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99135734
72negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99039523
73regulation of synapse structural plasticity (GO:0051823)2.98674712
74protein deneddylation (GO:0000338)2.94857384
75mating behavior (GO:0007617)2.94347641
76regulation of vesicle fusion (GO:0031338)2.93291644
77positive regulation of protein autophosphorylation (GO:0031954)2.92020681
78proline transport (GO:0015824)2.91597087
79cellular potassium ion homeostasis (GO:0030007)2.90944275
80synaptic vesicle endocytosis (GO:0048488)2.90577622
81regulation of synaptic transmission, glutamatergic (GO:0051966)2.90562403
82protein K6-linked ubiquitination (GO:0085020)2.90078437
83somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89260201
84somatic hypermutation of immunoglobulin genes (GO:0016446)2.89260201
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88869728
86axon ensheathment in central nervous system (GO:0032291)2.88585296
87central nervous system myelination (GO:0022010)2.88585296
88water-soluble vitamin biosynthetic process (GO:0042364)2.86936397
89synapsis (GO:0007129)2.86084495
90regulation of centriole replication (GO:0046599)2.85242444
91regulation of meiosis I (GO:0060631)2.84594403
92regulation of DNA endoreduplication (GO:0032875)2.83559638
93positive regulation of glycoprotein biosynthetic process (GO:0010560)2.83452150
94regulation of glutamate secretion (GO:0014048)2.82145627
95negative regulation of neurotransmitter transport (GO:0051589)2.81819361
96cerebellar Purkinje cell differentiation (GO:0021702)2.81774746
97respiratory chain complex IV assembly (GO:0008535)2.81682798
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81259219
99metaphase plate congression (GO:0051310)2.81032345
100activation of protein kinase A activity (GO:0034199)2.80777048
101neuronal ion channel clustering (GO:0045161)2.78468299
102DNA replication-independent nucleosome organization (GO:0034724)2.78359668
103DNA replication-independent nucleosome assembly (GO:0006336)2.78359668
104resolution of meiotic recombination intermediates (GO:0000712)2.77491154
105regulation of neurotransmitter secretion (GO:0046928)2.77115897
106behavioral defense response (GO:0002209)2.77049571
107behavioral fear response (GO:0001662)2.77049571
108regulation of mitotic spindle checkpoint (GO:1903504)2.76669951
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76669951
110membrane hyperpolarization (GO:0060081)2.76270347
111kinetochore organization (GO:0051383)2.75454389
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74508321
113cell migration in hindbrain (GO:0021535)2.74464654
114negative regulation of DNA recombination (GO:0045910)2.74054437
115female gonad development (GO:0008585)2.73898441
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73180837
117response to histamine (GO:0034776)2.72799360
118positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70649564
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70597822
120calcium ion-dependent exocytosis (GO:0017156)2.70580010
121regulation of dendritic spine development (GO:0060998)2.70128792
122fatty acid elongation (GO:0030497)2.69567041
123DNA catabolic process, exonucleolytic (GO:0000738)2.69218930
124neuromuscular process controlling balance (GO:0050885)2.68861775
125adult walking behavior (GO:0007628)2.68421546
126positive regulation of synapse maturation (GO:0090129)2.68340435
127pyrimidine nucleobase catabolic process (GO:0006208)2.67469881
128spindle checkpoint (GO:0031577)2.67185676
129double-strand break repair via homologous recombination (GO:0000724)2.66342000
130recombinational repair (GO:0000725)2.66082421
131vesicle transport along microtubule (GO:0047496)2.65605976
132regulation of neurotransmitter transport (GO:0051588)2.65536636
133synapse assembly (GO:0007416)2.64361723
134fear response (GO:0042596)2.64287778
135membrane depolarization (GO:0051899)2.64078925
136postreplication repair (GO:0006301)2.63770982
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63668765
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63668765
139isotype switching (GO:0045190)2.63668765
140learning (GO:0007612)2.63463855
141mitotic spindle checkpoint (GO:0071174)2.62507372
142prepulse inhibition (GO:0060134)2.62309969
143double-strand break repair via nonhomologous end joining (GO:0006303)2.60659078
144non-recombinational repair (GO:0000726)2.60659078
145intraciliary transport (GO:0042073)2.60325523
146peptidyl-cysteine modification (GO:0018198)2.60166609
147regulation of synaptic transmission (GO:0050804)2.59733056
148cerebellar granule cell differentiation (GO:0021707)2.59710236
149postsynaptic membrane organization (GO:0001941)2.59115181
150startle response (GO:0001964)2.58902367
151synapse organization (GO:0050808)2.57766067
152positive regulation of synapse assembly (GO:0051965)2.57193982
153branched-chain amino acid catabolic process (GO:0009083)2.57062915
154regulation of telomere maintenance (GO:0032204)2.57039308
155membrane depolarization during action potential (GO:0086010)2.56709634
156telomere maintenance via telomerase (GO:0007004)2.55614499
157positive regulation of dendritic spine development (GO:0060999)2.55352612
158neurotransmitter catabolic process (GO:0042135)2.55334595
159L-amino acid import (GO:0043092)2.55134656
160response to X-ray (GO:0010165)2.53401467
161regulation of Rac protein signal transduction (GO:0035020)2.51529397
162keratinocyte development (GO:0003334)2.51285437
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49697995
164regulation of translation, ncRNA-mediated (GO:0045974)2.49525775
165negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49525775
166negative regulation of translation, ncRNA-mediated (GO:0040033)2.49525775
167mitotic metaphase plate congression (GO:0007080)2.49382204
168protein prenylation (GO:0018342)2.46655073
169prenylation (GO:0097354)2.46655073
170neural tube formation (GO:0001841)2.45860466
171kinetochore assembly (GO:0051382)2.45059496
172purine nucleobase biosynthetic process (GO:0009113)2.44640574
173protein localization to kinetochore (GO:0034501)2.41056799
174intra-S DNA damage checkpoint (GO:0031573)2.40954240
175zinc ion transport (GO:0006829)2.40324181
176positive regulation of glycolytic process (GO:0045821)2.39198161
177negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.37367659
178negative regulation of mitotic sister chromatid segregation (GO:0033048)2.37367659
179negative regulation of mitotic sister chromatid separation (GO:2000816)2.37367659
180negative regulation of sister chromatid segregation (GO:0033046)2.37367659
181negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.37367659
182regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.35374859
183regulation of mitotic metaphase/anaphase transition (GO:0030071)2.35374859
184mitotic G2/M transition checkpoint (GO:0044818)2.33788263
185centriole replication (GO:0007099)2.33500923
186retinal ganglion cell axon guidance (GO:0031290)2.32779782
187DNA damage response, detection of DNA damage (GO:0042769)2.32693978
188atrial cardiac muscle cell action potential (GO:0086014)2.31184122
189microtubule polymerization or depolymerization (GO:0031109)2.30060443
190histone mRNA metabolic process (GO:0008334)2.30050098
191negative regulation of chromosome segregation (GO:0051985)2.29989121
192microtubule depolymerization (GO:0007019)2.29646916
193histone mRNA catabolic process (GO:0071044)2.29244300
194cytochrome complex assembly (GO:0017004)2.28976059
195dorsal/ventral axis specification (GO:0009950)2.28299684
196centrosome organization (GO:0051297)2.27661626
197vascular smooth muscle contraction (GO:0014829)2.26946397
198IMP biosynthetic process (GO:0006188)2.26885236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39092528
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.95689533
3GBX2_23144817_ChIP-Seq_PC3_Human3.65279172
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81460576
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76344552
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64753279
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.44553051
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44221922
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36746172
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36746172
11EWS_26573619_Chip-Seq_HEK293_Human2.35603288
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.33664487
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32809637
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29014894
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28359717
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27828532
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26570209
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.25201286
19TAF15_26573619_Chip-Seq_HEK293_Human2.25029152
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22607889
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17370608
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15180713
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.11938244
24E2F7_22180533_ChIP-Seq_HELA_Human2.09565041
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.07995423
26DROSHA_22980978_ChIP-Seq_HELA_Human2.05557661
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04333682
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02740930
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01179053
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01144284
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.99181054
32* REST_18959480_ChIP-ChIP_MESCs_Mouse1.97365294
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96927845
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.90589032
35AR_21572438_ChIP-Seq_LNCaP_Human1.85406112
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84690693
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84150134
38ELK1_19687146_ChIP-ChIP_HELA_Human1.80371482
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.79496327
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73138557
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.71329050
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67833528
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67157494
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67077323
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65191685
46SMAD4_21799915_ChIP-Seq_A2780_Human1.64445479
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61413264
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59214924
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57875154
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56862672
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55107801
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54420604
53P300_19829295_ChIP-Seq_ESCs_Human1.53222833
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.48444261
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48132380
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.46371088
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46325325
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45539953
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45298521
60ZNF274_21170338_ChIP-Seq_K562_Hela1.42696349
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.42200510
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41794288
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39679026
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37953152
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37192137
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.36608340
67VDR_22108803_ChIP-Seq_LS180_Human1.33259020
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.33112554
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.32320880
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31595072
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30011544
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29153931
73* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29117745
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.28214142
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26834413
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26516923
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26428192
78* STAT3_23295773_ChIP-Seq_U87_Human1.26237355
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25985183
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25425246
81* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25411339
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24933926
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24906019
84MYC_18940864_ChIP-ChIP_HL60_Human1.24558083
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.24025963
86* AR_25329375_ChIP-Seq_VCAP_Human1.23306626
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22841115
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21958819
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21669291
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21273459
91TCF4_22108803_ChIP-Seq_LS180_Human1.20602175
92NANOG_19829295_ChIP-Seq_ESCs_Human1.20589227
93SOX2_19829295_ChIP-Seq_ESCs_Human1.20589227
94FUS_26573619_Chip-Seq_HEK293_Human1.20022530
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19858718
96P53_22387025_ChIP-Seq_ESCs_Mouse1.19371516
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17240849
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16837592
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15873433
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15752274
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.15633946
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.14686243
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.13218062
104AR_21909140_ChIP-Seq_LNCAP_Human1.13103956
105RNF2_27304074_Chip-Seq_NSC_Mouse1.12739926
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.11890660
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11433927
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10375278
109TCF4_23295773_ChIP-Seq_U87_Human1.10243961
110* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09393826
111AR_19668381_ChIP-Seq_PC3_Human1.08690727
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08663512
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08631049
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08554978
115P300_18555785_Chip-Seq_ESCs_Mouse1.08420818
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.08305009
117* ER_23166858_ChIP-Seq_MCF-7_Human1.07686079
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06866421
119TP53_22573176_ChIP-Seq_HFKS_Human1.06682719
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.06421237
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05780701
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05368415
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.05351230
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05188687
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04738192
126CDX2_22108803_ChIP-Seq_LS180_Human1.04563234
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03861498
128VDR_23849224_ChIP-Seq_CD4+_Human1.03514008
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.01841187
130AHR_22903824_ChIP-Seq_MCF-7_Human1.00943701
131SOX9_26525672_Chip-Seq_HEART_Mouse1.00236338
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.99781277
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98859145
134STAT3_18555785_Chip-Seq_ESCs_Mouse0.98335269
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98160232
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97373144
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96958920
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96958920
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.96836804
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96333370
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.95577623
142BCAT_22108803_ChIP-Seq_LS180_Human0.95165969
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.94397907
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94343882
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94137611
146JUN_21703547_ChIP-Seq_K562_Human0.93315362
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.92688963
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.91450374
149* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91279409
150CBP_20019798_ChIP-Seq_JUKART_Human0.90418897
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90418897
152DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88901038
153IGF1R_20145208_ChIP-Seq_DFB_Human0.88874299
154TP53_18474530_ChIP-ChIP_U2OS_Human0.88742953
155* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88609622
156KDM2B_26808549_Chip-Seq_REH_Human0.87894509
157* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87198874
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.84876596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.42429529
2MP0003880_abnormal_central_pattern4.99373178
3MP0004270_analgesia3.71326781
4MP0003635_abnormal_synaptic_transmissio3.65266319
5MP0009745_abnormal_behavioral_response3.11634839
6MP0002064_seizures2.99383341
7MP0002063_abnormal_learning/memory/cond2.97443137
8MP0002102_abnormal_ear_morphology2.94705982
9MP0009046_muscle_twitch2.86634077
10MP0008877_abnormal_DNA_methylation2.70501114
11MP0005423_abnormal_somatic_nervous2.68717929
12MP0002572_abnormal_emotion/affect_behav2.61621156
13MP0002822_catalepsy2.56648980
14MP0002272_abnormal_nervous_system2.53264219
15MP0001968_abnormal_touch/_nociception2.51712929
16MP0001486_abnormal_startle_reflex2.48156387
17MP0010094_abnormal_chromosome_stability2.43627700
18MP0002938_white_spotting2.38517693
19MP0006054_spinal_hemorrhage2.33189019
20MP0002734_abnormal_mechanical_nocicepti2.29408347
21MP0003121_genomic_imprinting2.23815519
22MP0000569_abnormal_digit_pigmentation2.23004719
23MP0008058_abnormal_DNA_repair2.22805441
24MP0001501_abnormal_sleep_pattern2.13343160
25MP0003329_amyloid_beta_deposits2.10979559
26MP0001440_abnormal_grooming_behavior2.10126672
27MP0008057_abnormal_DNA_replication2.03773876
28MP0006276_abnormal_autonomic_nervous2.01029065
29MP0003890_abnormal_embryonic-extraembry2.00182414
30MP0001529_abnormal_vocalization1.92808480
31MP0000778_abnormal_nervous_system1.92356027
32MP0002736_abnormal_nociception_after1.90397006
33MP0002067_abnormal_sensory_capabilities1.81114430
34MP0002735_abnormal_chemical_nociception1.78232989
35MP0005386_behavior/neurological_phenoty1.74056320
36MP0004924_abnormal_behavior1.74056320
37MP0003718_maternal_effect1.73926678
38MP0002733_abnormal_thermal_nociception1.73921035
39MP0000516_abnormal_urinary_system1.73674978
40MP0005367_renal/urinary_system_phenotyp1.73674978
41MP0004885_abnormal_endolymph1.73014865
42MP0002751_abnormal_autonomic_nervous1.71725609
43MP0003283_abnormal_digestive_organ1.69654605
44MP0009780_abnormal_chondrocyte_physiolo1.68650659
45MP0002234_abnormal_pharynx_morphology1.68507215
46MP0006072_abnormal_retinal_apoptosis1.68364848
47MP0001970_abnormal_pain_threshold1.58737752
48MP0006292_abnormal_olfactory_placode1.57514082
49MP0001905_abnormal_dopamine_level1.56962817
50MP0002557_abnormal_social/conspecific_i1.56667860
51MP0002139_abnormal_hepatobiliary_system1.56298459
52MP0004142_abnormal_muscle_tone1.55769609
53MP0000647_abnormal_sebaceous_gland1.54675527
54MP0003119_abnormal_digestive_system1.52574433
55MP0002184_abnormal_innervation1.52491182
56MP0003122_maternal_imprinting1.51667112
57MP0004133_heterotaxia1.50207500
58MP0005646_abnormal_pituitary_gland1.49123442
59MP0001293_anophthalmia1.46624848
60MP0000955_abnormal_spinal_cord1.46215153
61MP0005253_abnormal_eye_physiology1.45499040
62MP0001984_abnormal_olfaction1.44908392
63MP0004811_abnormal_neuron_physiology1.42299065
64MP0008569_lethality_at_weaning1.41929371
65MP0003937_abnormal_limbs/digits/tail_de1.41628718
66MP0003111_abnormal_nucleus_morphology1.41489503
67MP0004858_abnormal_nervous_system1.39636291
68MP0002066_abnormal_motor_capabilities/c1.37777404
69MP0000920_abnormal_myelination1.37423716
70MP0002254_reproductive_system_inflammat1.36440215
71MP0000427_abnormal_hair_cycle1.36261501
72MP0002882_abnormal_neuron_morphology1.35695488
73MP0008007_abnormal_cellular_replicative1.34610975
74MP0005379_endocrine/exocrine_gland_phen1.34310539
75MP0003879_abnormal_hair_cell1.33821021
76MP0005360_urolithiasis1.31700028
77MP0003690_abnormal_glial_cell1.30657685
78MP0004957_abnormal_blastocyst_morpholog1.30215691
79MP0009697_abnormal_copulation1.30099017
80MP0004215_abnormal_myocardial_fiber1.29327541
81MP0003633_abnormal_nervous_system1.26636800
82MP0001502_abnormal_circadian_rhythm1.21598488
83MP0005085_abnormal_gallbladder_physiolo1.21085067
84MP0003693_abnormal_embryo_hatching1.20676997
85MP0002233_abnormal_nose_morphology1.19297938
86MP0008875_abnormal_xenobiotic_pharmacok1.19185896
87MP0005248_abnormal_Harderian_gland1.18775866
88MP0002909_abnormal_adrenal_gland1.17431093
89MP0005410_abnormal_fertilization1.16795132
90MP0003631_nervous_system_phenotype1.16679852
91MP0002229_neurodegeneration1.15947056
92MP0005551_abnormal_eye_electrophysiolog1.14199301
93MP0003941_abnormal_skin_development1.12760724
94MP0003787_abnormal_imprinting1.11461083
95MP0005645_abnormal_hypothalamus_physiol1.09837239
96MP0000372_irregular_coat_pigmentation1.08250104
97MP0002152_abnormal_brain_morphology1.06454454
98MP0000604_amyloidosis1.04718078
99MP0002163_abnormal_gland_morphology1.04491196
100MP0008932_abnormal_embryonic_tissue1.03323643
101MP0003755_abnormal_palate_morphology1.03275790
102MP0003567_abnormal_fetal_cardiomyocyte1.02136346
103MP0003632_abnormal_nervous_system1.01784618
104MP0008789_abnormal_olfactory_epithelium1.01707443
105MP0004742_abnormal_vestibular_system1.01647952
106MP0002876_abnormal_thyroid_physiology1.01502994
107MP0001929_abnormal_gametogenesis1.01435377
108MP0003634_abnormal_glial_cell1.00508139
109MP0005535_abnormal_body_temperature0.98650969
110MP0003123_paternal_imprinting0.97453544
111MP0001485_abnormal_pinna_reflex0.97331764
112MP0003786_premature_aging0.96928801
113MP0005365_abnormal_bile_salt0.95628787
114MP0008872_abnormal_physiological_respon0.95251286
115MP0003077_abnormal_cell_cycle0.95106155
116MP0002069_abnormal_eating/drinking_beha0.94456755
117MP0010307_abnormal_tumor_latency0.93487600
118MP0002638_abnormal_pupillary_reflex0.92683203
119MP0005395_other_phenotype0.92319217
120MP0009703_decreased_birth_body0.91956587
121MP0002837_dystrophic_cardiac_calcinosis0.90094002
122MP0000653_abnormal_sex_gland0.90032116
123MP0001963_abnormal_hearing_physiology0.88704807
124MP0010678_abnormal_skin_adnexa0.85542296
125MP0002090_abnormal_vision0.83118843
126MP0001177_atelectasis0.83015696
127MP0000383_abnormal_hair_follicle0.82525990
128MP0008874_decreased_physiological_sensi0.82312275
129MP0000013_abnormal_adipose_tissue0.81854667
130MP0001145_abnormal_male_reproductive0.81418082
131MP0003698_abnormal_male_reproductive0.81114086
132MP0005391_vision/eye_phenotype0.81014195
133MP0005075_abnormal_melanosome_morpholog0.80895661
134MP0002752_abnormal_somatic_nervous0.80888245
135MP0005220_abnormal_exocrine_pancreas0.80770206
136MP0002210_abnormal_sex_determination0.80245682
137MP0010352_gastrointestinal_tract_polyps0.79246258
138MP0004085_abnormal_heartbeat0.78046417
139MP0001286_abnormal_eye_development0.77421371
140MP0004233_abnormal_muscle_weight0.77165015
141MP0003137_abnormal_impulse_conducting0.76723723
142MP0004043_abnormal_pH_regulation0.76626380
143MP0005409_darkened_coat_color0.74861357
144MP0001188_hyperpigmentation0.73983088
145MP0000751_myopathy0.71323991
146MP0000631_abnormal_neuroendocrine_gland0.70310297
147MP0003011_delayed_dark_adaptation0.70062340
148MP0003943_abnormal_hepatobiliary_system0.69853724
149MP0003195_calcinosis0.69331514
150MP0004145_abnormal_muscle_electrophysio0.67827960
151MP0005332_abnormal_amino_acid0.65432389
152MP0005623_abnormal_meninges_morphology0.61231559
153MP0010329_abnormal_lipoprotein_level0.61179187
154MP0010386_abnormal_urinary_bladder0.60894186
155MP0008961_abnormal_basal_metabolism0.60130643
156MP0005187_abnormal_penis_morphology0.58382255
157MP0001299_abnormal_eye_distance/0.57274946
158MP0001664_abnormal_digestion0.57250077
159MP0005394_taste/olfaction_phenotype0.57184044
160MP0005499_abnormal_olfactory_system0.57184044
161MP0005171_absent_coat_pigmentation0.54678038
162MP0003861_abnormal_nervous_system0.54348263
163MP0000026_abnormal_inner_ear0.53895800
164MP0001943_abnormal_respiration0.53523469

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.36698296
2Myokymia (HP:0002411)5.66202418
3Focal seizures (HP:0007359)4.80815317
4Epileptic encephalopathy (HP:0200134)4.15276985
5Volvulus (HP:0002580)4.12050393
6Atonic seizures (HP:0010819)4.05533257
7Neurofibrillary tangles (HP:0002185)3.92193637
8Visual hallucinations (HP:0002367)3.90290718
9Abnormality of the labia minora (HP:0012880)3.87504881
10Hyperventilation (HP:0002883)3.82731563
11Absence seizures (HP:0002121)3.74163595
12Cerebral inclusion bodies (HP:0100314)3.64987406
13Progressive cerebellar ataxia (HP:0002073)3.61363202
14Supranuclear gaze palsy (HP:0000605)3.47459974
15Generalized tonic-clonic seizures (HP:0002069)3.45678592
16Dialeptic seizures (HP:0011146)3.45201278
17Action tremor (HP:0002345)3.25199645
18Termporal pattern (HP:0011008)3.22084922
19Insidious onset (HP:0003587)3.22084922
20Abnormality of the corticospinal tract (HP:0002492)3.14001403
21Intestinal atresia (HP:0011100)3.12543533
22Pancreatic fibrosis (HP:0100732)3.11135175
23Febrile seizures (HP:0002373)3.09240124
24Impaired vibration sensation in the lower limbs (HP:0002166)3.07716439
25Dysmetria (HP:0001310)3.05400373
26Pancreatic cysts (HP:0001737)3.04820015
27Spastic gait (HP:0002064)3.04690837
28Ankle clonus (HP:0011448)2.98587247
29Hypoglycemic seizures (HP:0002173)2.97951230
30Dysdiadochokinesis (HP:0002075)2.94294542
31Broad-based gait (HP:0002136)2.94005427
32Abnormal eating behavior (HP:0100738)2.86525251
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.85365954
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.85365954
35Abnormality of chromosome stability (HP:0003220)2.82379687
36True hermaphroditism (HP:0010459)2.81762039
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.80764608
38Anxiety (HP:0000739)2.79073564
39Pancreatic islet-cell hyperplasia (HP:0004510)2.78302832
40Meckel diverticulum (HP:0002245)2.76509463
41Pheochromocytoma (HP:0002666)2.74360076
42Ependymoma (HP:0002888)2.72990621
43Urinary bladder sphincter dysfunction (HP:0002839)2.68865021
44Hypoglycemic coma (HP:0001325)2.68465837
45Abnormality of the ileum (HP:0001549)2.68380287
46Amblyopia (HP:0000646)2.66289843
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66233044
48Scanning speech (HP:0002168)2.62570901
49Chromsome breakage (HP:0040012)2.61645874
50Supernumerary spleens (HP:0009799)2.61554993
51Colon cancer (HP:0003003)2.61047514
52Postural instability (HP:0002172)2.60796465
53Intention tremor (HP:0002080)2.60638972
54Aqueductal stenosis (HP:0002410)2.59226620
55Drooling (HP:0002307)2.58881008
56Excessive salivation (HP:0003781)2.58881008
57Poor eye contact (HP:0000817)2.57058026
58Truncal ataxia (HP:0002078)2.56347222
59Hyperinsulinemic hypoglycemia (HP:0000825)2.56302101
60Epileptiform EEG discharges (HP:0011182)2.55905703
61Abnormality of the lower motor neuron (HP:0002366)2.55545257
62Neoplasm of the adrenal cortex (HP:0100641)2.53954255
63Hypothermia (HP:0002045)2.52845317
64Urinary urgency (HP:0000012)2.52222171
65Gaze-evoked nystagmus (HP:0000640)2.51192811
66Abnormality of the astrocytes (HP:0100707)2.50347196
67Astrocytoma (HP:0009592)2.50347196
68Impaired social interactions (HP:0000735)2.48562576
69Abnormal social behavior (HP:0012433)2.48562576
70Depression (HP:0000716)2.48237761
71Glioma (HP:0009733)2.46513213
72EEG with generalized epileptiform discharges (HP:0011198)2.45511140
73Status epilepticus (HP:0002133)2.43880007
74Torticollis (HP:0000473)2.42413661
75Polyphagia (HP:0002591)2.41708726
76Generalized myoclonic seizures (HP:0002123)2.40618422
77Hemiparesis (HP:0001269)2.38954363
78Abnormality of the pancreatic islet cells (HP:0006476)2.38492469
79Abnormality of endocrine pancreas physiology (HP:0012093)2.38492469
80Medial flaring of the eyebrow (HP:0010747)2.38467259
81Abnormal lung lobation (HP:0002101)2.37175806
82Hypsarrhythmia (HP:0002521)2.33834574
83Neuroendocrine neoplasm (HP:0100634)2.33649173
84Abnormality of the preputium (HP:0100587)2.33156618
85Abnormality of midbrain morphology (HP:0002418)2.31582925
86Molar tooth sign on MRI (HP:0002419)2.31582925
87Focal dystonia (HP:0004373)2.31193877
88Rhabdomyosarcoma (HP:0002859)2.29000713
89Lower limb muscle weakness (HP:0007340)2.25651996
90Limb dystonia (HP:0002451)2.23828179
91Abnormality of the duodenum (HP:0002246)2.22394324
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.20562962
93Genital tract atresia (HP:0001827)2.20376553
94Craniofacial dystonia (HP:0012179)2.15578041
95Small hand (HP:0200055)2.15438023
96Progressive inability to walk (HP:0002505)2.14380366
97Absent/shortened dynein arms (HP:0200106)2.12788033
98Dynein arm defect of respiratory motile cilia (HP:0012255)2.12788033
99Impaired vibratory sensation (HP:0002495)2.12146083
100Bradykinesia (HP:0002067)2.11048684
101Morphological abnormality of the pyramidal tract (HP:0002062)2.09966593
102Absent speech (HP:0001344)2.09617843
103Sloping forehead (HP:0000340)2.08559271
104Duodenal stenosis (HP:0100867)2.08316866
105Small intestinal stenosis (HP:0012848)2.08316866
106Congenital primary aphakia (HP:0007707)2.07564605
107Vaginal atresia (HP:0000148)2.06744490
108Neoplasm of the adrenal gland (HP:0100631)2.04446964
109Nephronophthisis (HP:0000090)2.04183428
110Mutism (HP:0002300)2.03365386
111Abnormality of the renal cortex (HP:0011035)2.03123170
112Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02613776
113Blue irides (HP:0000635)2.02389158
114Renal cortical cysts (HP:0000803)2.02144945
115Abnormal biliary tract physiology (HP:0012439)2.01198388
116Bile duct proliferation (HP:0001408)2.01198388
117Delusions (HP:0000746)2.00376098
118Aplasia/Hypoplasia of the tibia (HP:0005772)2.00249645
119Gastrointestinal atresia (HP:0002589)1.99868841
120Megalencephaly (HP:0001355)1.99122846
121Abnormality of the metopic suture (HP:0005556)1.96501380
122Renal hypoplasia (HP:0000089)1.96193544
123Genetic anticipation (HP:0003743)1.95510215
124Cholecystitis (HP:0001082)1.95367198
125Abnormal gallbladder physiology (HP:0012438)1.95367198
126Clonus (HP:0002169)1.94730385
127Embryonal renal neoplasm (HP:0011794)1.94147303
128Retinal dysplasia (HP:0007973)1.93435396
129Akinesia (HP:0002304)1.93187960
130Symptomatic seizures (HP:0011145)1.93058400
131Bifid tongue (HP:0010297)1.93035152
132Disproportionate short-trunk short stature (HP:0003521)1.92566448
133Cystic liver disease (HP:0006706)1.91999386
134Gait imbalance (HP:0002141)1.91483600
135Abnormality of methionine metabolism (HP:0010901)1.91410933
136Short tibia (HP:0005736)1.91162040
137Methylmalonic acidemia (HP:0002912)1.90905866
138Sclerocornea (HP:0000647)1.89888678
139Dandy-Walker malformation (HP:0001305)1.88587098
140Diplopia (HP:0000651)1.88187329
141Abnormality of binocular vision (HP:0011514)1.88187329
142Nephroblastoma (Wilms tumor) (HP:0002667)1.87878958
143Anencephaly (HP:0002323)1.87305376
144Labial hypoplasia (HP:0000066)1.87202740
145Postaxial hand polydactyly (HP:0001162)1.87021435
146Psychosis (HP:0000709)1.85500057
147Sensory axonal neuropathy (HP:0003390)1.85004009
148Preaxial hand polydactyly (HP:0001177)1.84386520
149Nephrogenic diabetes insipidus (HP:0009806)1.84297124
150Neuronal loss in central nervous system (HP:0002529)1.83566585
151Hypoplastic female external genitalia (HP:0012815)1.82541402
152Increased circulating renin level (HP:0000848)1.82040631
153Prominent metopic ridge (HP:0005487)1.80887545
154Narrow forehead (HP:0000341)1.80466248
155Thickened helices (HP:0000391)1.80285510
156Abnormal biliary tract morphology (HP:0012440)1.79497797
157Occipital encephalocele (HP:0002085)1.78971339
158Impaired smooth pursuit (HP:0007772)1.78373578
159Gait ataxia (HP:0002066)1.78192287
160Spastic tetraparesis (HP:0001285)1.77787338
161Hemiplegia (HP:0002301)1.77280795
162Abnormality of the renal medulla (HP:0100957)1.77231942
163Agitation (HP:0000713)1.77007904
164Progressive macrocephaly (HP:0004481)1.76781211
165Amyotrophic lateral sclerosis (HP:0007354)1.76690556
166Astigmatism (HP:0000483)1.76439176
167Abolished electroretinogram (ERG) (HP:0000550)1.76154756
168Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76026702
169Specific learning disability (HP:0001328)1.75922004
170Adrenal hypoplasia (HP:0000835)1.75551561
171Peripheral hypomyelination (HP:0007182)1.75260621
172Hyperglycinuria (HP:0003108)1.74855305
173Inability to walk (HP:0002540)1.74605151
174Deep venous thrombosis (HP:0002625)1.74218076
175Optic nerve hypoplasia (HP:0000609)1.73961710
176Breast carcinoma (HP:0003002)1.73498555
177Postaxial foot polydactyly (HP:0001830)1.72979530
178Male pseudohermaphroditism (HP:0000037)1.71319524
179Hyperglycinemia (HP:0002154)1.71283206
180Limb hypertonia (HP:0002509)1.71263828
181Clubbing of toes (HP:0100760)1.71103332
182Hammertoe (HP:0001765)1.70918567
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70542698
184Ectopic kidney (HP:0000086)1.68922109
185Stereotypic behavior (HP:0000733)1.68432253
186Rigidity (HP:0002063)1.67722780
187Abnormality of the parathyroid morphology (HP:0011766)1.67346091
188Hyperglycemia (HP:0003074)1.66844843
189Double outlet right ventricle (HP:0001719)1.66511560
190Congenital malformation of the right heart (HP:0011723)1.66511560
191Abnormality of serine family amino acid metabolism (HP:0010894)1.66412484
192Abnormality of glycine metabolism (HP:0010895)1.66412484
193Abnormality of salivation (HP:0100755)1.66007153
194Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65746249
195Acute encephalopathy (HP:0006846)1.65704672
196Abnormality of saccadic eye movements (HP:0000570)1.64470595
197Hepatoblastoma (HP:0002884)1.64026566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.12278995
2NTRK34.01320981
3FRK3.90559190
4TRIM283.82273426
5MKNK23.37367840
6MAP3K43.18238803
7MAP3K93.16215258
8MARK12.88143037
9MAP2K72.56067578
10BUB12.51658099
11EIF2AK32.48901750
12ACVR1B2.43687478
13MINK12.37359536
14BMPR1B2.37066199
15ERBB32.32259297
16MKNK12.25042419
17PAK62.19026740
18PLK32.18226634
19CASK2.16651489
20MAP2K42.11842922
21PNCK2.09223019
22NTRK22.07231421
23DAPK21.97075871
24KSR21.96945108
25NUAK11.94654504
26OXSR11.94179979
27NTRK11.92484655
28STK391.84369721
29WEE11.79309375
30ZAK1.78774303
31BRSK21.69366353
32MAP4K21.66837540
33PLK41.61410016
34MAP3K121.61403125
35CDK191.61196588
36NEK11.59044602
37KSR11.58350725
38TTK1.58180173
39PRKD31.56627664
40EIF2AK11.52439688
41MST41.50211036
42TNIK1.48609167
43CDK51.43771957
44TSSK61.41211495
45UHMK11.37887899
46PLK21.33833028
47SIK31.30665891
48GRK11.25125884
49MAPK131.24339230
50SRPK11.23628721
51TYRO31.23440348
52PRPF4B1.19278121
53STK31.18970849
54CSNK1G21.18946619
55ARAF1.17530941
56GRK51.16913797
57PRKCG1.16570156
58CDC71.16502377
59PLK11.15567788
60WNK41.14884899
61RIPK41.14069711
62CAMK2A1.13161072
63PAK31.11617718
64CAMKK11.10169878
65SGK2231.05345339
66SGK4941.05345339
67MAP3K21.03783446
68LATS21.03108139
69CAMK2B1.02626809
70FGFR20.98703591
71DAPK10.97989152
72BCR0.97939185
73STK380.97042817
74CDK140.96473775
75VRK10.95416909
76PHKG10.94093846
77PHKG20.94093846
78PBK0.93038388
79CDK180.92766708
80CDK150.91750551
81BCKDK0.91671577
82EIF2AK20.91440584
83WNK30.89906200
84TGFBR10.89858345
85FES0.89149942
86STK38L0.87680118
87INSRR0.86595122
88PDK40.85855004
89PDK30.85855004
90PKN10.85203463
91MAP3K130.84335394
92PTK2B0.81671197
93STK110.78755924
94CSNK1G30.78254780
95CDK11A0.78103049
96SIK20.75849341
97WNK10.72541204
98MARK20.71183824
99ADRBK20.69797531
100RET0.69516725
101ATM0.68812535
102BRSK10.67642579
103MUSK0.66870973
104CAMK2D0.64914703
105STK160.64512244
106ATR0.63328041
107CAMK1G0.63120740
108NLK0.62657107
109FGFR10.62202480
110DYRK1A0.62022091
111RAF10.61898943
112CAMK10.60556027
113CAMK2G0.60457477
114PDPK10.60188532
115ICK0.59954383
116SGK10.59661849
117PASK0.59623763
118BMPR20.58858052
119DYRK20.58696863
120TAF10.58408546
121ROCK20.58235973
122CSNK1A1L0.58192079
123PRKCZ0.57965786
124PRKCH0.56423130
125NEK60.55637260
126FGR0.55127364
127SGK20.54588658
128NME10.54353591
129PRKCE0.53432885
130CAMKK20.53228990
131PDK10.52336043
132ERBB40.51614438
133TAOK10.49117027
134MAP3K10.47955526
135MAP2K10.47650601
136BRD40.47565096
137FER0.46950716
138CSNK1G10.46773801
139RPS6KA30.45018497
140AKT30.44701391
141LMTK20.44560388
142PINK10.44401437
143SGK30.44253379
144CHEK20.44084447
145VRK20.43100988
146MAPK100.41740232
147MAPKAPK50.41237110
148PRKDC0.39380770
149TIE10.39310042
150ROCK10.38348972
151FLT30.35965411
152CCNB10.34655030
153YES10.33899820
154RPS6KA40.33714547
155CSNK1E0.30987444
156CHEK10.30798352
157NEK20.29367025
158CSNK1D0.28506639
159CDK10.28343366
160CDK30.26734731
161DYRK30.26652236

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34565007
2Non-homologous end-joining_Homo sapiens_hsa034503.14921364
3Protein export_Homo sapiens_hsa030602.81505011
4Synaptic vesicle cycle_Homo sapiens_hsa047212.81500416
5GABAergic synapse_Homo sapiens_hsa047272.52200377
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33482790
7Fanconi anemia pathway_Homo sapiens_hsa034602.27123272
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.24678037
9Glutamatergic synapse_Homo sapiens_hsa047242.21538733
10Circadian entrainment_Homo sapiens_hsa047132.19970306
11Homologous recombination_Homo sapiens_hsa034402.15817976
12Nitrogen metabolism_Homo sapiens_hsa009102.14930482
13Amphetamine addiction_Homo sapiens_hsa050312.11083768
14Long-term potentiation_Homo sapiens_hsa047202.10087817
15Morphine addiction_Homo sapiens_hsa050322.06458984
16Mismatch repair_Homo sapiens_hsa034302.05264277
17Proteasome_Homo sapiens_hsa030502.02633711
18Olfactory transduction_Homo sapiens_hsa047401.99000287
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88241958
20Dopaminergic synapse_Homo sapiens_hsa047281.86585972
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78834677
22Salivary secretion_Homo sapiens_hsa049701.78573577
23Basal transcription factors_Homo sapiens_hsa030221.74990653
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74583290
25Butanoate metabolism_Homo sapiens_hsa006501.67863910
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67184727
27Collecting duct acid secretion_Homo sapiens_hsa049661.61254618
28Insulin secretion_Homo sapiens_hsa049111.57556979
29Serotonergic synapse_Homo sapiens_hsa047261.55694917
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54412817
31Cocaine addiction_Homo sapiens_hsa050301.52968136
32Renin secretion_Homo sapiens_hsa049241.52349888
33RNA transport_Homo sapiens_hsa030131.51233190
34Taste transduction_Homo sapiens_hsa047421.49283122
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49231465
36RNA degradation_Homo sapiens_hsa030181.48490382
37Cholinergic synapse_Homo sapiens_hsa047251.46679697
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46412923
39Long-term depression_Homo sapiens_hsa047301.44313815
40Gastric acid secretion_Homo sapiens_hsa049711.42810412
41RNA polymerase_Homo sapiens_hsa030201.41988664
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.40992735
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40232145
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39928221
45Selenocompound metabolism_Homo sapiens_hsa004501.38907683
46One carbon pool by folate_Homo sapiens_hsa006701.38661633
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36876735
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32558261
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30705254
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.26892395
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25004739
52Cell cycle_Homo sapiens_hsa041101.24284535
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24113080
54Arginine biosynthesis_Homo sapiens_hsa002201.22803542
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22001225
56DNA replication_Homo sapiens_hsa030301.19334208
57Calcium signaling pathway_Homo sapiens_hsa040201.19162004
58Oxytocin signaling pathway_Homo sapiens_hsa049211.18829534
59Caffeine metabolism_Homo sapiens_hsa002321.16506109
60Axon guidance_Homo sapiens_hsa043601.15266084
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12878658
62Gap junction_Homo sapiens_hsa045401.08701786
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07094251
64Bile secretion_Homo sapiens_hsa049761.04910872
65GnRH signaling pathway_Homo sapiens_hsa049121.03170561
66Peroxisome_Homo sapiens_hsa041461.01778725
67beta-Alanine metabolism_Homo sapiens_hsa004100.99507207
68Vibrio cholerae infection_Homo sapiens_hsa051100.98238880
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98160353
70Regulation of autophagy_Homo sapiens_hsa041400.97657892
71Fatty acid elongation_Homo sapiens_hsa000620.95750585
72Steroid biosynthesis_Homo sapiens_hsa001000.95715576
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93330842
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91810790
75Cardiac muscle contraction_Homo sapiens_hsa042600.91439995
76Hedgehog signaling pathway_Homo sapiens_hsa043400.90745586
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90185881
78cAMP signaling pathway_Homo sapiens_hsa040240.89846291
79Circadian rhythm_Homo sapiens_hsa047100.88514720
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85183533
81Purine metabolism_Homo sapiens_hsa002300.83471224
82Nucleotide excision repair_Homo sapiens_hsa034200.81941108
83Pyruvate metabolism_Homo sapiens_hsa006200.81234046
84Estrogen signaling pathway_Homo sapiens_hsa049150.81192376
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80166291
86Retinol metabolism_Homo sapiens_hsa008300.79598730
87ErbB signaling pathway_Homo sapiens_hsa040120.77934678
88Oxidative phosphorylation_Homo sapiens_hsa001900.77184682
89Propanoate metabolism_Homo sapiens_hsa006400.75870345
90Base excision repair_Homo sapiens_hsa034100.75539947
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75402530
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75257236
93Type II diabetes mellitus_Homo sapiens_hsa049300.75116041
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75000936
95Fatty acid metabolism_Homo sapiens_hsa012120.73629090
96Melanogenesis_Homo sapiens_hsa049160.72562020
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.71581348
98Alzheimers disease_Homo sapiens_hsa050100.70921564
99TGF-beta signaling pathway_Homo sapiens_hsa043500.70120184
100Glioma_Homo sapiens_hsa052140.67692339
101Dorso-ventral axis formation_Homo sapiens_hsa043200.67294693
102p53 signaling pathway_Homo sapiens_hsa041150.67093043
103Wnt signaling pathway_Homo sapiens_hsa043100.65545847
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65415603
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65290716
106Hippo signaling pathway_Homo sapiens_hsa043900.65246831
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64944070
108Spliceosome_Homo sapiens_hsa030400.64886336
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64635899
110Pancreatic secretion_Homo sapiens_hsa049720.64556473
111Thyroid hormone synthesis_Homo sapiens_hsa049180.64005413
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63579343
113mRNA surveillance pathway_Homo sapiens_hsa030150.62849047
114Fatty acid biosynthesis_Homo sapiens_hsa000610.61578571
115Phototransduction_Homo sapiens_hsa047440.61185221
116Pyrimidine metabolism_Homo sapiens_hsa002400.60736370
117Linoleic acid metabolism_Homo sapiens_hsa005910.59988127
118Glucagon signaling pathway_Homo sapiens_hsa049220.59383027
119Metabolic pathways_Homo sapiens_hsa011000.59341818
120Prion diseases_Homo sapiens_hsa050200.58809631
121Folate biosynthesis_Homo sapiens_hsa007900.57037079
122Chemical carcinogenesis_Homo sapiens_hsa052040.56761182
123Tryptophan metabolism_Homo sapiens_hsa003800.55976829
124Glutathione metabolism_Homo sapiens_hsa004800.54590976
125ABC transporters_Homo sapiens_hsa020100.54192727
126Basal cell carcinoma_Homo sapiens_hsa052170.53534340
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.52867331
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.52537659
129Lysine degradation_Homo sapiens_hsa003100.52183366
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51171681
131Vitamin B6 metabolism_Homo sapiens_hsa007500.49544054
132Sulfur metabolism_Homo sapiens_hsa009200.49461239
133Parkinsons disease_Homo sapiens_hsa050120.48503403
134Oocyte meiosis_Homo sapiens_hsa041140.48124672
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47829462
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47443744
137Choline metabolism in cancer_Homo sapiens_hsa052310.47222603
138Carbon metabolism_Homo sapiens_hsa012000.45382789
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45251750
140PPAR signaling pathway_Homo sapiens_hsa033200.44836724
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44026927
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43929432
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43168857
144Ether lipid metabolism_Homo sapiens_hsa005650.43159158
145Ras signaling pathway_Homo sapiens_hsa040140.42624834
146Fatty acid degradation_Homo sapiens_hsa000710.42065851
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41981214
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41207178
149Glycerolipid metabolism_Homo sapiens_hsa005610.39713856
150Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39583347
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39351345
152Arginine and proline metabolism_Homo sapiens_hsa003300.38672794
153MAPK signaling pathway_Homo sapiens_hsa040100.38547455
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37692069
155Phenylalanine metabolism_Homo sapiens_hsa003600.37438069
156Tyrosine metabolism_Homo sapiens_hsa003500.36302823
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.34973260
158Ovarian steroidogenesis_Homo sapiens_hsa049130.34961227
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33528546
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33302403
161Histidine metabolism_Homo sapiens_hsa003400.32501347

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