DCUN1D5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.28730870
2DNA deamination (GO:0045006)4.57364556
3establishment of integrated proviral latency (GO:0075713)4.41772780
4ribosomal small subunit assembly (GO:0000028)4.37925168
5negative regulation of ligase activity (GO:0051352)4.31766075
6negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.31766075
7regulation of cellular amino acid metabolic process (GO:0006521)4.07740937
8regulation of mitochondrial translation (GO:0070129)3.80076085
9mitotic metaphase plate congression (GO:0007080)3.79063681
10positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.77787950
11DNA replication initiation (GO:0006270)3.76618044
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70446315
13nuclear pore complex assembly (GO:0051292)3.69617559
14telomere maintenance via semi-conservative replication (GO:0032201)3.69472333
15maturation of SSU-rRNA (GO:0030490)3.68850759
16intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68628675
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68628675
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.67404395
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.67404395
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.67404395
21DNA strand elongation involved in DNA replication (GO:0006271)3.65043897
22CENP-A containing nucleosome assembly (GO:0034080)3.64408236
23chromatin remodeling at centromere (GO:0031055)3.63674313
24establishment of viral latency (GO:0019043)3.59916878
25positive regulation of ligase activity (GO:0051351)3.59866359
26signal transduction involved in DNA integrity checkpoint (GO:0072401)3.59639006
27signal transduction involved in DNA damage checkpoint (GO:0072422)3.59639006
28regulation of ubiquitin-protein transferase activity (GO:0051438)3.59180974
29nuclear pore organization (GO:0006999)3.56012557
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.55358809
31cullin deneddylation (GO:0010388)3.53759743
32DNA strand elongation (GO:0022616)3.52692888
33telomere maintenance via recombination (GO:0000722)3.52092853
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51333772
35DNA replication checkpoint (GO:0000076)3.48929143
36protein localization to kinetochore (GO:0034501)3.46604893
37sister chromatid segregation (GO:0000819)3.46197534
38regulation of ligase activity (GO:0051340)3.44808732
39DNA replication-independent nucleosome assembly (GO:0006336)3.40080287
40DNA replication-independent nucleosome organization (GO:0034724)3.40080287
41protein localization to chromosome, centromeric region (GO:0071459)3.39858391
42regulation of mitotic spindle organization (GO:0060236)3.39072801
43formation of translation preinitiation complex (GO:0001731)3.36334030
44ribosome assembly (GO:0042255)3.34953838
45spliceosomal snRNP assembly (GO:0000387)3.34125272
46mitotic nuclear envelope disassembly (GO:0007077)3.32418965
47kinetochore organization (GO:0051383)3.32388253
48protein deneddylation (GO:0000338)3.32197328
49translational termination (GO:0006415)3.29609836
50negative regulation of chromosome segregation (GO:0051985)3.29424841
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29272382
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29272176
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.29106448
54negative regulation of sister chromatid segregation (GO:0033046)3.29106448
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29106448
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29106448
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29106448
58mitotic recombination (GO:0006312)3.28798738
59mitotic spindle checkpoint (GO:0071174)3.25202278
60viral transcription (GO:0019083)3.25169637
61mitotic spindle assembly checkpoint (GO:0007094)3.22022502
62folic acid-containing compound biosynthetic process (GO:0009396)3.20934442
63transcription from mitochondrial promoter (GO:0006390)3.20586870
64spindle assembly checkpoint (GO:0071173)3.18756845
65metaphase plate congression (GO:0051310)3.18637432
66protein targeting to mitochondrion (GO:0006626)3.17331772
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.17314859
68chaperone-mediated protein transport (GO:0072321)3.16367392
69establishment of chromosome localization (GO:0051303)3.15587934
70ribosomal large subunit biogenesis (GO:0042273)3.14762573
71DNA ligation (GO:0006266)3.14210251
72ribosome biogenesis (GO:0042254)3.12515474
73nuclear envelope disassembly (GO:0051081)3.10786088
74membrane disassembly (GO:0030397)3.10786088
75DNA damage response, detection of DNA damage (GO:0042769)3.08988459
76ribonucleoprotein complex biogenesis (GO:0022613)3.06940052
77mitotic chromosome condensation (GO:0007076)3.06609201
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05203357
79mitochondrial RNA metabolic process (GO:0000959)3.05046865
80regulation of cellular amine metabolic process (GO:0033238)3.04885655
81DNA unwinding involved in DNA replication (GO:0006268)3.04517464
82tRNA aminoacylation for protein translation (GO:0006418)3.04314046
83kinetochore assembly (GO:0051382)3.04277946
84protein complex localization (GO:0031503)3.04026033
85pore complex assembly (GO:0046931)3.02330095
86ventricular cardiac muscle cell development (GO:0055015)3.01513679
87histone exchange (GO:0043486)3.01144630
88attachment of spindle microtubules to kinetochore (GO:0008608)3.00324841
89deoxyribonucleotide biosynthetic process (GO:0009263)3.00176657
90translational initiation (GO:0006413)3.00099084
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99569325
92amino acid activation (GO:0043038)2.98903868
93tRNA aminoacylation (GO:0043039)2.98903868
94negative regulation of protein ubiquitination (GO:0031397)2.97891818
95translational elongation (GO:0006414)2.97374149
96protein maturation by protein folding (GO:0022417)2.94994933
97protein targeting to ER (GO:0045047)2.94553091
98telomere maintenance via telomere lengthening (GO:0010833)2.94509845
99nucleobase-containing small molecule interconversion (GO:0015949)2.94444728
100cotranslational protein targeting to membrane (GO:0006613)2.94188889
101nucleotide-excision repair, DNA gap filling (GO:0006297)2.94030056
102ribosomal small subunit biogenesis (GO:0042274)2.92713583
103nucleobase biosynthetic process (GO:0046112)2.89868327
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88728877
105maturation of 5.8S rRNA (GO:0000460)2.88088148
106protein localization to mitochondrion (GO:0070585)2.87966673
107monoubiquitinated protein deubiquitination (GO:0035520)2.86271895
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86213005
109purine nucleobase biosynthetic process (GO:0009113)2.83872758
110meiotic chromosome segregation (GO:0045132)2.82834720
111IMP biosynthetic process (GO:0006188)2.81966117
112DNA replication-dependent nucleosome organization (GO:0034723)2.80609158
113DNA replication-dependent nucleosome assembly (GO:0006335)2.80609158
114establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80295901
115protein localization to endoplasmic reticulum (GO:0070972)2.78680108
116rRNA processing (GO:0006364)2.76069420
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.75751086
118IMP metabolic process (GO:0046040)2.75227780
119protein K6-linked ubiquitination (GO:0085020)2.74135009
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73819063
121chromatin assembly or disassembly (GO:0006333)2.72308371
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66891869
123rRNA metabolic process (GO:0016072)2.66750215
124regulation of spindle organization (GO:0090224)2.66023215
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65913218
126G1/S transition of mitotic cell cycle (GO:0000082)2.65808044
127cell cycle G1/S phase transition (GO:0044843)2.65808044
128mitotic sister chromatid cohesion (GO:0007064)2.63697148
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62010179
130spindle checkpoint (GO:0031577)2.60954104
131pseudouridine synthesis (GO:0001522)2.60262436
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60253288
133transcription-coupled nucleotide-excision repair (GO:0006283)2.59719190
134viral life cycle (GO:0019058)2.56245061
1353-UTR-mediated mRNA stabilization (GO:0070935)2.55480855
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51320755
137translation (GO:0006412)2.50744707
138histone mRNA metabolic process (GO:0008334)2.50544005
139cellular protein complex disassembly (GO:0043624)2.50160847
140antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.48493485
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.47845743
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.47845743
143positive regulation of mitotic sister chromatid separation (GO:1901970)2.47845743
144protein localization to chromosome (GO:0034502)2.47371656
145mitotic sister chromatid segregation (GO:0000070)2.47005659
146maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46389089
147nuclear-transcribed mRNA catabolic process (GO:0000956)2.46314845
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.46076110
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.46076110
150isotype switching (GO:0045190)2.46076110
151telomere maintenance (GO:0000723)2.46024336
152regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45625162
153Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45589417
154regulation of chromosome segregation (GO:0051983)2.44607835
155telomere organization (GO:0032200)2.44296215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.58295403
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89054896
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55778880
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.39324794
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36911744
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.08253603
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93484807
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92549119
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.76717808
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53188728
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51860525
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51722286
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.47785683
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44526105
15VDR_23849224_ChIP-Seq_CD4+_Human2.42724494
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39050731
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23053314
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21675262
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.18630918
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16870898
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05263776
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03794676
23DCP1A_22483619_ChIP-Seq_HELA_Human2.02802340
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02558668
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.99856138
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.98424253
27* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94196023
28* XRN2_22483619_ChIP-Seq_HELA_Human1.93811989
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91413899
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90928443
31AR_21909140_ChIP-Seq_LNCAP_Human1.90584955
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89269320
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88119782
34FOXP3_21729870_ChIP-Seq_TREG_Human1.85624724
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81775191
36* GABP_19822575_ChIP-Seq_HepG2_Human1.79633096
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78378586
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78308778
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78296430
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72056005
41* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72014851
42MYC_22102868_ChIP-Seq_BL_Human1.69015277
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68549143
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.66582639
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66130735
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65365712
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64011781
48TTF2_22483619_ChIP-Seq_HELA_Human1.59658534
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58090851
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57129316
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.54362759
52SPI1_23547873_ChIP-Seq_NB4_Human1.51295146
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.50226257
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46362485
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43176906
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42368138
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41175014
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40757425
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40733682
60KDM5A_27292631_Chip-Seq_BREAST_Human1.34704620
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33245438
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31852686
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30981703
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30267935
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.29790323
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29677198
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28937435
68CIITA_25753668_ChIP-Seq_RAJI_Human1.27917785
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25653674
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23432744
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23369929
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22689091
73TFEB_21752829_ChIP-Seq_HELA_Human1.21458989
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21133593
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17328030
76MYB_26560356_Chip-Seq_TH2_Human1.16688900
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11392125
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10324379
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10027589
80MYB_26560356_Chip-Seq_TH1_Human1.09856347
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08836496
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08765571
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06881065
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06866017
85MYC_18940864_ChIP-ChIP_HL60_Human1.05547812
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05038194
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.04966095
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04897977
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04461648
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04416701
91ZNF263_19887448_ChIP-Seq_K562_Human1.04262310
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03861836
93* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02312360
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02288777
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02106172
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01726149
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.00951074
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.99290667
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97672192
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97470337
101* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96298761
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94484593
103* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94106398
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93477757
105RUNX1_22412390_ChIP-Seq_EML_Mouse0.93277770
106BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93152636
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91512984
108MAF_26560356_Chip-Seq_TH1_Human0.91290957
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91076253
110TP63_19390658_ChIP-ChIP_HaCaT_Human0.91004494
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90849074
112VDR_21846776_ChIP-Seq_THP-1_Human0.90719971
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90380387
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89496883
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.88445217
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86557144
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86504326
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85904258
119* ELK1_22589737_ChIP-Seq_MCF10A_Human0.85022981
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83874885
121* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82810749
122SCL_19346495_ChIP-Seq_HPC-7_Human0.81978133
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81318036
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79592376
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78934398
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76409577
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.76176076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66090912
2MP0003806_abnormal_nucleotide_metabolis4.25701178
3MP0004957_abnormal_blastocyst_morpholog3.56975768
4MP0010094_abnormal_chromosome_stability3.34274471
5MP0003111_abnormal_nucleus_morphology3.21470298
6MP0003077_abnormal_cell_cycle3.21207769
7MP0000372_irregular_coat_pigmentation3.10978840
8MP0009697_abnormal_copulation2.84857484
9MP0008057_abnormal_DNA_replication2.81484925
10MP0008007_abnormal_cellular_replicative2.74325454
11MP0002396_abnormal_hematopoietic_system2.65919950
12MP0001835_abnormal_antigen_presentation2.52696761
13MP0003941_abnormal_skin_development2.36254933
14MP0008058_abnormal_DNA_repair2.30035944
15MP0010352_gastrointestinal_tract_polyps2.19593428
16MP0009333_abnormal_splenocyte_physiolog2.11623529
17MP0003763_abnormal_thymus_physiology2.09176631
18MP0000490_abnormal_crypts_of2.06014725
19MP0010307_abnormal_tumor_latency2.00388696
20MP0005671_abnormal_response_to1.96660123
21MP0008932_abnormal_embryonic_tissue1.92977576
22MP0006035_abnormal_mitochondrial_morpho1.88358459
23MP0004808_abnormal_hematopoietic_stem1.86659969
24MP0000685_abnormal_immune_system1.84920546
25MP0009785_altered_susceptibility_to1.80844545
26MP0003436_decreased_susceptibility_to1.77714674
27MP0006054_spinal_hemorrhage1.77457930
28MP0000350_abnormal_cell_proliferation1.74669065
29MP0003123_paternal_imprinting1.73091248
30MP0002398_abnormal_bone_marrow1.71848342
31MP0004233_abnormal_muscle_weight1.70940369
32MP0006036_abnormal_mitochondrial_physio1.70386473
33MP0002006_tumorigenesis1.63939488
34MP0001545_abnormal_hematopoietic_system1.63462142
35MP0005397_hematopoietic_system_phenotyp1.63462142
36MP0005000_abnormal_immune_tolerance1.59562429
37MP0001730_embryonic_growth_arrest1.55905704
38MP0008877_abnormal_DNA_methylation1.53798428
39MP0002019_abnormal_tumor_incidence1.53279287
40MP0002877_abnormal_melanocyte_morpholog1.51657906
41MP0002148_abnormal_hypersensitivity_rea1.49761398
42MP0002452_abnormal_antigen_presenting1.47496495
43MP0001800_abnormal_humoral_immune1.47182606
44MP0002166_altered_tumor_susceptibility1.45832085
45MP0000858_altered_metastatic_potential1.45550529
46MP0002420_abnormal_adaptive_immunity1.45066107
47MP0001819_abnormal_immune_cell1.43714863
48MP0006292_abnormal_olfactory_placode1.39769900
49MP0000689_abnormal_spleen_morphology1.38288409
50MP0002722_abnormal_immune_system1.37325359
51MP0002405_respiratory_system_inflammati1.36639612
52MP0005025_abnormal_response_to1.35265461
53MP0002723_abnormal_immune_serum1.34632336
54MP0000716_abnormal_immune_system1.33303871
55MP0002102_abnormal_ear_morphology1.33067718
56MP0003890_abnormal_embryonic-extraembry1.30560173
57MP0003136_yellow_coat_color1.29836957
58MP0002429_abnormal_blood_cell1.29156169
59MP0001293_anophthalmia1.28992462
60MP0001853_heart_inflammation1.28705622
61MP0009672_abnormal_birth_weight1.28328604
62MP0002938_white_spotting1.27451192
63MP0010030_abnormal_orbit_morphology1.26942692
64MP0000537_abnormal_urethra_morphology1.26894283
65MP0003567_abnormal_fetal_cardiomyocyte1.26236330
66MP0001529_abnormal_vocalization1.25737141
67MP0000313_abnormal_cell_death1.25348106
68MP0000703_abnormal_thymus_morphology1.25256808
69MP0001697_abnormal_embryo_size1.23508734
70MP0005076_abnormal_cell_differentiation1.22944399
71MP0001790_abnormal_immune_system1.22521439
72MP0005387_immune_system_phenotype1.22521439
73MP0003786_premature_aging1.22511405
74MP0002419_abnormal_innate_immunity1.21218943
75MP0003186_abnormal_redox_activity1.21049274
76MP0003646_muscle_fatigue1.19089911
77MP0003718_maternal_effect1.17274508
78MP0005501_abnormal_skin_physiology1.17172040
79MP0001727_abnormal_embryo_implantation1.12636189
80MP0003937_abnormal_limbs/digits/tail_de1.11683643
81MP0003448_altered_tumor_morphology1.11440593
82MP0002234_abnormal_pharynx_morphology1.09306050
83MP0002080_prenatal_lethality1.06553366
84MP0005464_abnormal_platelet_physiology1.06014334
85MP0005380_embryogenesis_phenotype1.05909234
86MP0001672_abnormal_embryogenesis/_devel1.05909234
87MP0003315_abnormal_perineum_morphology1.04911115
88MP0005075_abnormal_melanosome_morpholog1.04568271
89MP0001661_extended_life_span1.03045001
90MP0000647_abnormal_sebaceous_gland1.02987915
91MP0010155_abnormal_intestine_physiology1.02783428
92MP0000678_abnormal_parathyroid_gland1.02005725
93MP0002086_abnormal_extraembryonic_tissu1.02001450
94MP0003984_embryonic_growth_retardation1.01178340
95MP0003221_abnormal_cardiomyocyte_apopto0.99756439
96MP0005171_absent_coat_pigmentation0.99702878
97MP0000343_altered_response_to0.99573359
98MP0003303_peritoneal_inflammation0.98655549
99MP0000465_gastrointestinal_hemorrhage0.97641080
100MP0002160_abnormal_reproductive_system0.97636555
101MP0002088_abnormal_embryonic_growth/wei0.97230818
102MP0002796_impaired_skin_barrier0.96787454
103MP0010234_abnormal_vibrissa_follicle0.95455625
104MP0001119_abnormal_female_reproductive0.94154277
105MP0000015_abnormal_ear_pigmentation0.94064824
106MP0002177_abnormal_outer_ear0.92149123
107MP0003724_increased_susceptibility_to0.91460653
108MP0001845_abnormal_inflammatory_respons0.91151200
109MP0002210_abnormal_sex_determination0.90866180
110MP0004197_abnormal_fetal_growth/weight/0.86032855
111MP0008789_abnormal_olfactory_epithelium0.85372384
112MP0002090_abnormal_vision0.84932631
113MP0002132_abnormal_respiratory_system0.84749983
114MP0002085_abnormal_embryonic_tissue0.84547801
115MP0001915_intracranial_hemorrhage0.84142980
116MP0002095_abnormal_skin_pigmentation0.83337266
117MP0005174_abnormal_tail_pigmentation0.83005211
118MP0002697_abnormal_eye_size0.82388135
119MP0002084_abnormal_developmental_patter0.79865623
120MP0005023_abnormal_wound_healing0.78326847
121MP0001929_abnormal_gametogenesis0.77615328
122MP0001533_abnormal_skeleton_physiology0.76982003
123MP0001145_abnormal_male_reproductive0.76512057
124MP0000358_abnormal_cell_content/0.76035994
125MP0002269_muscular_atrophy0.75920044
126MP0003656_abnormal_erythrocyte_physiolo0.75803934
127MP0003121_genomic_imprinting0.75528136
128MP0002111_abnormal_tail_morphology0.75394970
129MP0002233_abnormal_nose_morphology0.74308566
130MP0005330_cardiomyopathy0.73244065
131MP0008260_abnormal_autophagy0.72529265
132MP0005408_hypopigmentation0.72180725
133MP0000653_abnormal_sex_gland0.71492130
134MP0005621_abnormal_cell_physiology0.71381059
135MP0006072_abnormal_retinal_apoptosis0.70692598
136MP0006082_CNS_inflammation0.70084714
137MP0005384_cellular_phenotype0.67864140
138MP0004947_skin_inflammation0.67836438
139MP0005395_other_phenotype0.66782398
140MP0003705_abnormal_hypodermis_morpholog0.66097951
141MP0003385_abnormal_body_wall0.65277903
142MP0000733_abnormal_muscle_development0.65021779
143MP0005623_abnormal_meninges_morphology0.61168994
144MP0003119_abnormal_digestive_system0.60270822
145MP0000477_abnormal_intestine_morphology0.60113732
146MP0003699_abnormal_female_reproductive0.59835898
147MP0001286_abnormal_eye_development0.59440729
148MP0002092_abnormal_eye_morphology0.59124596
149MP0002060_abnormal_skin_morphology0.58869940
150MP0009703_decreased_birth_body0.58426008
151MP0005499_abnormal_olfactory_system0.58338446
152MP0005394_taste/olfaction_phenotype0.58338446
153MP0000049_abnormal_middle_ear0.57717380
154MP0005257_abnormal_intraocular_pressure0.55148173
155MP0001881_abnormal_mammary_gland0.54821591
156MP0001324_abnormal_eye_pigmentation0.54478763

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.39313589
2Abnormal mitochondria in muscle tissue (HP:0008316)4.24941216
3Aplastic anemia (HP:0001915)4.11842189
4Acute necrotizing encephalopathy (HP:0006965)4.10246447
5Abnormality of cells of the erythroid lineage (HP:0012130)3.83084420
6Acute encephalopathy (HP:0006846)3.78600565
7Thrombocytosis (HP:0001894)3.78176234
8Abnormal number of erythroid precursors (HP:0012131)3.63463978
9Reticulocytopenia (HP:0001896)3.51796516
10Increased CSF lactate (HP:0002490)3.31594486
11Progressive macrocephaly (HP:0004481)3.20624998
12Mitochondrial inheritance (HP:0001427)3.14021997
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13785713
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13785713
15Abnormality of glycolysis (HP:0004366)3.07094085
16Cerebral edema (HP:0002181)2.98743797
17Increased serum pyruvate (HP:0003542)2.95431969
18Recurrent abscess formation (HP:0002722)2.94165046
19Facial cleft (HP:0002006)2.93346414
20Myositis (HP:0100614)2.90202325
21Carpal bone hypoplasia (HP:0001498)2.85194595
22Oral leukoplakia (HP:0002745)2.84591663
23Elevated erythrocyte sedimentation rate (HP:0003565)2.83585131
2411 pairs of ribs (HP:0000878)2.81066631
25Hepatocellular necrosis (HP:0001404)2.77538189
26Myelodysplasia (HP:0002863)2.77338978
27Microvesicular hepatic steatosis (HP:0001414)2.76965464
28IgM deficiency (HP:0002850)2.68585534
29Abnormal lung lobation (HP:0002101)2.67048309
30Breast hypoplasia (HP:0003187)2.65337780
31Chromsome breakage (HP:0040012)2.64231864
32Abnormal protein glycosylation (HP:0012346)2.62252098
33Abnormal glycosylation (HP:0012345)2.62252098
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62252098
35Abnormal protein N-linked glycosylation (HP:0012347)2.62252098
36Increased hepatocellular lipid droplets (HP:0006565)2.60372419
37Hepatic necrosis (HP:0002605)2.60308944
38Increased serum lactate (HP:0002151)2.60168881
39Cortical dysplasia (HP:0002539)2.57421252
40Trismus (HP:0000211)2.56639912
41Pallor (HP:0000980)2.55959321
42Abnormality of chromosome stability (HP:0003220)2.55919451
43Muscle fiber atrophy (HP:0100295)2.52319396
44Patellar aplasia (HP:0006443)2.51672070
45Abnormality of T cell physiology (HP:0011840)2.51174923
46Progressive muscle weakness (HP:0003323)2.48765306
47Lactic acidosis (HP:0003128)2.48496802
48Increased intramyocellular lipid droplets (HP:0012240)2.48281742
49Exercise intolerance (HP:0003546)2.47521813
50Hypokinesia (HP:0002375)2.47108613
51Microretrognathia (HP:0000308)2.45419817
52Abnormality of methionine metabolism (HP:0010901)2.44702329
53Acute myeloid leukemia (HP:0004808)2.42979850
54Lipid accumulation in hepatocytes (HP:0006561)2.40394832
55Abnormality of alanine metabolism (HP:0010916)2.38730260
56Hyperalaninemia (HP:0003348)2.38730260
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38730260
58Aplasia/Hypoplasia of the patella (HP:0006498)2.36962975
59IgG deficiency (HP:0004315)2.34617552
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32546636
61Retrobulbar optic neuritis (HP:0100654)2.28469733
62Optic neuritis (HP:0100653)2.28469733
63Premature graying of hair (HP:0002216)2.27986868
64Recurrent bacterial skin infections (HP:0005406)2.27879364
65Abnormal spermatogenesis (HP:0008669)2.27846749
66Poor head control (HP:0002421)2.26693657
67Eczematoid dermatitis (HP:0000976)2.26640411
68Multiple enchondromatosis (HP:0005701)2.24951759
69Type 2 muscle fiber atrophy (HP:0003554)2.23065813
70Abnormal auditory evoked potentials (HP:0006958)2.22691341
71Abnormal gallbladder physiology (HP:0012438)2.20484320
72Cholecystitis (HP:0001082)2.20484320
73Abnormality of the anterior horn cell (HP:0006802)2.19750066
74Degeneration of anterior horn cells (HP:0002398)2.19750066
75Absent thumb (HP:0009777)2.19260145
76Reduced antithrombin III activity (HP:0001976)2.19028666
77Abnormality of T cells (HP:0002843)2.18978560
78Meckel diverticulum (HP:0002245)2.17735579
79Ependymoma (HP:0002888)2.16792080
80Sparse eyelashes (HP:0000653)2.15950383
81Colon cancer (HP:0003003)2.15846519
82Proximal placement of thumb (HP:0009623)2.15557794
83Cutaneous melanoma (HP:0012056)2.15279762
84Bone marrow hypocellularity (HP:0005528)2.14463120
85Orchitis (HP:0100796)2.14357201
86Lymphoma (HP:0002665)2.13986344
87Pulmonary fibrosis (HP:0002206)2.13845058
88Recurrent viral infections (HP:0004429)2.12394861
89Rough bone trabeculation (HP:0100670)2.10560983
90Medulloblastoma (HP:0002885)2.10012967
91Cerebral hypomyelination (HP:0006808)2.09620439
92Leukodystrophy (HP:0002415)2.09517153
93Neoplasm of the colon (HP:0100273)2.08997413
94Macrocytic anemia (HP:0001972)2.08971832
95Abnormality of the preputium (HP:0100587)2.08926274
96Respiratory failure (HP:0002878)2.08240799
97Slender long bone (HP:0003100)2.08032855
98Increased nuchal translucency (HP:0010880)2.07965493
99Petechiae (HP:0000967)2.07650055
100Recurrent bronchitis (HP:0002837)2.06810718
101Agnosia (HP:0010524)2.06237799
102Horseshoe kidney (HP:0000085)2.04868142
103Type I transferrin isoform profile (HP:0003642)2.04627208
104Median cleft lip (HP:0000161)2.04028362
105Capillary hemangiomas (HP:0005306)2.01952720
106Ragged-red muscle fibers (HP:0003200)2.00574777
107Shoulder girdle muscle weakness (HP:0003547)1.99982488
108Deviation of the thumb (HP:0009603)1.99839551
109Nephroblastoma (Wilms tumor) (HP:0002667)1.99555998
110Increased muscle lipid content (HP:0009058)1.99287416
111Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98421417
112Abnormality of the ileum (HP:0001549)1.98413434
113Spastic diplegia (HP:0001264)1.97602829
114Entropion (HP:0000621)1.97566615
115Irregular epiphyses (HP:0010582)1.97416186
116Abnormality of the calcaneus (HP:0008364)1.97168567
117Patchy hypopigmentation of hair (HP:0011365)1.96932250
118Exertional dyspnea (HP:0002875)1.95786673
119Ulnar deviation of the wrist (HP:0003049)1.95705138
120Postnatal microcephaly (HP:0005484)1.94899224
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.94491588
122Recurrent fungal infections (HP:0002841)1.91796906
123Selective tooth agenesis (HP:0001592)1.91697073
124Calcaneovalgus deformity (HP:0001848)1.90894502
125Facial hemangioma (HP:0000329)1.89760891
126Embryonal renal neoplasm (HP:0011794)1.89589574
127Abnormality of serum amino acid levels (HP:0003112)1.88712566
128Mediastinal lymphadenopathy (HP:0100721)1.88264019
129Absent radius (HP:0003974)1.85920481
130Poikiloderma (HP:0001029)1.84617478
131Abnormality of the umbilical cord (HP:0010881)1.82339499
132Abnormality of the duodenum (HP:0002246)1.82111698
133Neoplasm of the rectum (HP:0100743)1.80737242
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80693526
135Hyperglycinemia (HP:0002154)1.79983089
136Deformed tarsal bones (HP:0008119)1.79634489
137Megaloblastic anemia (HP:0001889)1.77792303
138Absent forearm bone (HP:0003953)1.77475851
139Aplasia involving forearm bones (HP:0009822)1.77475851
140Encephalitis (HP:0002383)1.77195252
141Lethargy (HP:0001254)1.76735400
142Stomatitis (HP:0010280)1.76044536
143Glossoptosis (HP:0000162)1.75632857
144Combined immunodeficiency (HP:0005387)1.75433045
145Short middle phalanx of the 5th finger (HP:0004220)1.75432021
146Abnormalities of placenta or umbilical cord (HP:0001194)1.75375996
147Severe combined immunodeficiency (HP:0004430)1.74950753
148Aseptic necrosis (HP:0010885)1.74777280
149Neoplasm of the pancreas (HP:0002894)1.74755875
150Abnormality of T cell number (HP:0011839)1.74590911
151IgA deficiency (HP:0002720)1.73696782
152Amniotic constriction ring (HP:0009775)1.73454213
153Abnormality of placental membranes (HP:0011409)1.73454213
154Cervical subluxation (HP:0003308)1.72786727
155Pancytopenia (HP:0001876)1.72374490
156Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71887779
157Bifid tongue (HP:0010297)1.71487215
158T lymphocytopenia (HP:0005403)1.70758197
159Abnormality of the fetal cardiovascular system (HP:0010948)1.70425282
160Abnormal umbilical cord blood vessels (HP:0011403)1.70425282
161Single umbilical artery (HP:0001195)1.70425282
162Upper limb muscle weakness (HP:0003484)1.70338040
163Azoospermia (HP:0000027)1.70294411
164Panhypogammaglobulinemia (HP:0003139)1.69666748
165Cellular immunodeficiency (HP:0005374)1.67748424
166Amaurosis fugax (HP:0100576)1.67331444
167Small intestinal stenosis (HP:0012848)1.66851183
168Duodenal stenosis (HP:0100867)1.66851183
169Squamous cell carcinoma (HP:0002860)1.66790163
170Secondary amenorrhea (HP:0000869)1.64612978
171Sloping forehead (HP:0000340)1.63957370
172Cleft eyelid (HP:0000625)1.63849662
173Abnormality of the heme biosynthetic pathway (HP:0010472)1.63708736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.59110507
2CDC73.49547701
3WEE13.03327355
4ACVR1B2.84431268
5SRPK12.71426846
6BUB12.61581153
7EIF2AK32.60427668
8VRK22.42569287
9EIF2AK12.40098420
10NEK22.26806277
11PLK42.25346453
12RPS6KA42.21340631
13BRSK21.97336485
14JAK31.94668698
15STK161.92664195
16TRIM281.80937912
17PDK21.74793536
18LATS11.70049383
19VRK11.55960922
20SCYL21.54722375
21DYRK31.51870912
22MAP4K11.47525937
23TESK21.47382268
24PIM21.46356473
25MST1R1.42075565
26TXK1.41985770
27AURKB1.34429615
28PLK11.32859553
29STK31.28709347
30BCKDK1.28551272
31PIM11.24997237
32BCR1.23832570
33MET1.23749422
34EPHA21.22836790
35CDK81.21683981
36FLT31.21169536
37RPS6KB21.18239346
38ARAF1.18091936
39RAF11.17941941
40CSNK1G31.15970996
41TYK21.15564786
42PKN21.15031294
43CDK41.14406748
44TEC1.14351577
45MKNK11.13344375
46CHEK21.09726337
47CCNB11.08682970
48TTK1.08679765
49ZAP701.08599112
50TAF11.06229518
51MAP3K81.05041707
52ABL21.04735399
53TLK11.03594868
54TESK11.03166734
55KIT1.02409966
56ATR1.01723023
57ZAK1.01717876
58IRAK41.01608979
59CSNK1A1L1.01454318
60PLK31.00295549
61CSNK1G10.98741113
62CDK70.98677119
63STK100.97657132
64MKNK20.97572199
65LATS20.97332383
66TGFBR10.96539038
67NEK90.95431885
68MAP2K30.94712900
69MAP3K140.93525493
70MST40.91571705
71MAP3K50.89443940
72CSNK1G20.88660894
73DAPK10.88107261
74BRSK10.87649098
75CDK190.86847776
76KDR0.86627880
77ERBB30.85639243
78STK38L0.85258554
79TBK10.83656624
80BTK0.82570136
81NEK10.80226523
82LRRK20.79333950
83EEF2K0.79205560
84MAP3K110.78555880
85IKBKB0.78484443
86CHEK10.77153080
87PASK0.75669245
88MARK30.75503965
89MAP2K70.74978297
90MAP3K120.74705443
91MAP3K60.73537636
92NLK0.72003568
93TAOK20.71742071
94AURKA0.71362085
95MELK0.69455523
96LIMK10.68823061
97CLK10.68374610
98STK240.67510063
99MAP3K30.66959469
100SIK30.65614214
101STK40.65235525
102EIF2AK20.63456436
103MAP4K20.61322746
104PAK40.61184173
105MYLK0.60248887
106PLK20.58983623
107NUAK10.58454381
108ALK0.57729720
109IRAK30.57192181
110ERBB40.57135947
111CSNK2A20.56170651
112ILK0.55903790
113PBK0.55853981
114PAK10.55075370
115PNCK0.53910854
116BRAF0.53705765
117CDK60.53606088
118ATM0.53167285
119DYRK20.51516382
120SYK0.50707658
121MAP3K100.50378280
122CDK10.49739939
123TSSK60.49384815
124CDK90.48768342
125CSF1R0.48493071
126CSNK2A10.47884474
127NME10.47525497
128TRPM70.46326229
129RPS6KA50.46031041
130CDK20.45276386
131LYN0.43420058
132PTK20.42567775
133CDK140.39732901
134PRKCI0.36462442
135SMG10.36134751
136CDK180.35170704
137MINK10.33998708
138CSNK1E0.32189318
139CDK11A0.32157546
140AKT20.32085849
141WNK30.31801428

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.02505547
2Ribosome_Homo sapiens_hsa030103.13754556
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06874874
4Mismatch repair_Homo sapiens_hsa034303.04865534
5Proteasome_Homo sapiens_hsa030503.00577487
6RNA polymerase_Homo sapiens_hsa030202.84727320
7Spliceosome_Homo sapiens_hsa030402.52389189
8Cell cycle_Homo sapiens_hsa041102.52272831
9RNA transport_Homo sapiens_hsa030132.50180872
10Homologous recombination_Homo sapiens_hsa034402.44685366
11Nucleotide excision repair_Homo sapiens_hsa034202.43639907
12Base excision repair_Homo sapiens_hsa034102.34373730
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33609427
14Pyrimidine metabolism_Homo sapiens_hsa002402.16450852
15Oxidative phosphorylation_Homo sapiens_hsa001902.16109701
16RNA degradation_Homo sapiens_hsa030182.00598533
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95131672
18Basal transcription factors_Homo sapiens_hsa030221.88657900
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82237520
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79899135
21Fatty acid elongation_Homo sapiens_hsa000621.79383471
22p53 signaling pathway_Homo sapiens_hsa041151.73686029
23Protein export_Homo sapiens_hsa030601.72913637
24Fanconi anemia pathway_Homo sapiens_hsa034601.67251198
25Antigen processing and presentation_Homo sapiens_hsa046121.66461566
26One carbon pool by folate_Homo sapiens_hsa006701.65727215
27Biosynthesis of amino acids_Homo sapiens_hsa012301.50937802
28Herpes simplex infection_Homo sapiens_hsa051681.48984751
29Pyruvate metabolism_Homo sapiens_hsa006201.47551257
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44330467
31Non-homologous end-joining_Homo sapiens_hsa034501.42429929
32Carbon metabolism_Homo sapiens_hsa012001.35619640
33Primary immunodeficiency_Homo sapiens_hsa053401.33762593
34Allograft rejection_Homo sapiens_hsa053301.30965494
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.30593587
36Legionellosis_Homo sapiens_hsa051341.29136907
37Epstein-Barr virus infection_Homo sapiens_hsa051691.27506427
38Graft-versus-host disease_Homo sapiens_hsa053321.26541828
39mRNA surveillance pathway_Homo sapiens_hsa030151.26307868
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26036283
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24778739
42Alzheimers disease_Homo sapiens_hsa050101.24404926
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21403259
44Systemic lupus erythematosus_Homo sapiens_hsa053221.21304858
45Measles_Homo sapiens_hsa051621.18586794
46Leishmaniasis_Homo sapiens_hsa051401.18397614
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.10286131
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02841922
49Glutathione metabolism_Homo sapiens_hsa004801.01776771
50Purine metabolism_Homo sapiens_hsa002301.01567468
51Viral carcinogenesis_Homo sapiens_hsa052031.01377350
52Steroid biosynthesis_Homo sapiens_hsa001000.99602502
53Propanoate metabolism_Homo sapiens_hsa006400.99463232
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98132805
55Pentose phosphate pathway_Homo sapiens_hsa000300.97187200
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96950126
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96233529
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95175175
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91395578
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89594340
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88789161
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87584099
63Shigellosis_Homo sapiens_hsa051310.87073498
64Hepatitis B_Homo sapiens_hsa051610.86821640
65Asthma_Homo sapiens_hsa053100.85284865
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84081022
67Apoptosis_Homo sapiens_hsa042100.83546291
68HTLV-I infection_Homo sapiens_hsa051660.83088220
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82789777
70Influenza A_Homo sapiens_hsa051640.82212989
71Vitamin B6 metabolism_Homo sapiens_hsa007500.80552413
72Folate biosynthesis_Homo sapiens_hsa007900.80054823
73Hematopoietic cell lineage_Homo sapiens_hsa046400.78426789
74Sulfur metabolism_Homo sapiens_hsa009200.77029216
75Thyroid cancer_Homo sapiens_hsa052160.76289869
76Small cell lung cancer_Homo sapiens_hsa052220.73611350
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71986884
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71450242
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69532154
80Malaria_Homo sapiens_hsa051440.69188477
81B cell receptor signaling pathway_Homo sapiens_hsa046620.68605209
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66812136
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65904970
84Viral myocarditis_Homo sapiens_hsa054160.65808774
85Galactose metabolism_Homo sapiens_hsa000520.65595951
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.65374280
87Metabolic pathways_Homo sapiens_hsa011000.65078814
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63860031
89TNF signaling pathway_Homo sapiens_hsa046680.62937561
90T cell receptor signaling pathway_Homo sapiens_hsa046600.61996407
91Sulfur relay system_Homo sapiens_hsa041220.61156676
92Toxoplasmosis_Homo sapiens_hsa051450.61102671
93MicroRNAs in cancer_Homo sapiens_hsa052060.60132613
94Type I diabetes mellitus_Homo sapiens_hsa049400.58704283
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58421410
96TGF-beta signaling pathway_Homo sapiens_hsa043500.55006469
97Osteoclast differentiation_Homo sapiens_hsa043800.54711121
98Acute myeloid leukemia_Homo sapiens_hsa052210.54515214
99Autoimmune thyroid disease_Homo sapiens_hsa053200.54205549
100Oocyte meiosis_Homo sapiens_hsa041140.53960922
101Chronic myeloid leukemia_Homo sapiens_hsa052200.53913734
102Pancreatic cancer_Homo sapiens_hsa052120.52460908
103Salmonella infection_Homo sapiens_hsa051320.51642171
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51600554
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51569298
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51528377
107Tuberculosis_Homo sapiens_hsa051520.51226394
108Huntingtons disease_Homo sapiens_hsa050160.50515128
109N-Glycan biosynthesis_Homo sapiens_hsa005100.48615714
110Colorectal cancer_Homo sapiens_hsa052100.47174169
111Vibrio cholerae infection_Homo sapiens_hsa051100.47070897
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46078897
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45973264
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44749503
115Selenocompound metabolism_Homo sapiens_hsa004500.44693876
116Pertussis_Homo sapiens_hsa051330.44230609
117Arginine and proline metabolism_Homo sapiens_hsa003300.42986060
118Fructose and mannose metabolism_Homo sapiens_hsa000510.42586937
119Tyrosine metabolism_Homo sapiens_hsa003500.41549156
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41153415
121Phenylalanine metabolism_Homo sapiens_hsa003600.37764215
122Cardiac muscle contraction_Homo sapiens_hsa042600.37376565
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37344896
124Fatty acid metabolism_Homo sapiens_hsa012120.36316937
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.34028227
126Prolactin signaling pathway_Homo sapiens_hsa049170.31975435
127Prostate cancer_Homo sapiens_hsa052150.31564615
128Peroxisome_Homo sapiens_hsa041460.30839832
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29036782
130Alcoholism_Homo sapiens_hsa050340.28833742
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.27933606
132Hippo signaling pathway_Homo sapiens_hsa043900.27769225
133HIF-1 signaling pathway_Homo sapiens_hsa040660.26672339
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.26010073
135Non-small cell lung cancer_Homo sapiens_hsa052230.25990004
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25927238
137Parkinsons disease_Homo sapiens_hsa050120.25420407
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19370111
139Collecting duct acid secretion_Homo sapiens_hsa049660.17216959
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.16774278
141Adherens junction_Homo sapiens_hsa045200.10915340
142Tight junction_Homo sapiens_hsa045300.09192002
143beta-Alanine metabolism_Homo sapiens_hsa004100.08787626
144Arginine biosynthesis_Homo sapiens_hsa002200.06739189
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.06388877
146Wnt signaling pathway_Homo sapiens_hsa043100.06269556
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05383137
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05193777
149Bladder cancer_Homo sapiens_hsa052190.04392587

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