DDAH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.37366020
2L-phenylalanine catabolic process (GO:0006559)4.37366020
3pyrimidine nucleobase catabolic process (GO:0006208)4.32421142
4L-phenylalanine metabolic process (GO:0006558)4.26169031
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.26169031
6glyoxylate metabolic process (GO:0046487)4.04590313
7positive regulation of actin filament depolymerization (GO:0030836)3.96208932
8alpha-linolenic acid metabolic process (GO:0036109)3.94198815
9aromatic amino acid family catabolic process (GO:0009074)3.93619737
10lysine metabolic process (GO:0006553)3.86107085
11lysine catabolic process (GO:0006554)3.86107085
12glutamate metabolic process (GO:0006536)3.84007539
13cellular ketone body metabolic process (GO:0046950)3.83887257
14cysteine metabolic process (GO:0006534)3.79950740
15serine family amino acid catabolic process (GO:0009071)3.70742722
16tryptophan catabolic process (GO:0006569)3.64254636
17indole-containing compound catabolic process (GO:0042436)3.64254636
18indolalkylamine catabolic process (GO:0046218)3.64254636
19cellular modified amino acid catabolic process (GO:0042219)3.63109879
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.60890069
21dicarboxylic acid biosynthetic process (GO:0043650)3.60839782
22fibroblast migration (GO:0010761)3.55517547
23sulfur amino acid catabolic process (GO:0000098)3.47351411
24homocysteine metabolic process (GO:0050667)3.46468861
25negative regulation of fibrinolysis (GO:0051918)3.46080132
26vocalization behavior (GO:0071625)3.43808247
27kynurenine metabolic process (GO:0070189)3.43677532
28negative regulation of protein localization to cell surface (GO:2000009)3.41520100
29vascular smooth muscle contraction (GO:0014829)3.41333068
30actin filament depolymerization (GO:0030042)3.39137021
31neurotransmitter-gated ion channel clustering (GO:0072578)3.37888217
32tryptophan metabolic process (GO:0006568)3.32752378
33bile acid biosynthetic process (GO:0006699)3.31196682
34nucleobase catabolic process (GO:0046113)3.29138918
35serine family amino acid biosynthetic process (GO:0009070)3.29051120
36ketone body metabolic process (GO:1902224)3.28020787
37* alpha-amino acid catabolic process (GO:1901606)3.20990333
38presynaptic membrane assembly (GO:0097105)3.12969367
39reverse cholesterol transport (GO:0043691)3.12824860
40* cellular amino acid catabolic process (GO:0009063)3.12179681
41membrane assembly (GO:0071709)3.11846348
42aspartate family amino acid catabolic process (GO:0009068)3.10973920
43glutamate secretion (GO:0014047)3.10803417
44dicarboxylic acid catabolic process (GO:0043649)3.10433475
45positive regulation of protein autophosphorylation (GO:0031954)3.09288317
46drug catabolic process (GO:0042737)3.09212861
47chondrocyte proliferation (GO:0035988)3.06556661
48negative regulation of sodium ion transport (GO:0010766)3.06098584
49serine family amino acid metabolic process (GO:0009069)3.04567748
50alanine transport (GO:0032328)3.04505913
51regulation of fibrinolysis (GO:0051917)3.02999094
52amino-acid betaine metabolic process (GO:0006577)3.02265969
53cellular glucuronidation (GO:0052695)3.01941531
54L-serine metabolic process (GO:0006563)3.01277713
55urate metabolic process (GO:0046415)3.00943058
56high-density lipoprotein particle remodeling (GO:0034375)2.98956977
57muscle cell cellular homeostasis (GO:0046716)2.98688770
58negative regulation of axon guidance (GO:1902668)2.98346447
59gamma-aminobutyric acid transport (GO:0015812)2.98321525
60regulation of integrin-mediated signaling pathway (GO:2001044)2.96711210
61coenzyme catabolic process (GO:0009109)2.95972385
62regulation of chemokine-mediated signaling pathway (GO:0070099)2.95645847
63aromatic amino acid family metabolic process (GO:0009072)2.94148987
64low-density lipoprotein particle remodeling (GO:0034374)2.91322954
65fructose metabolic process (GO:0006000)2.90948392
66negative regulation of axon extension involved in axon guidance (GO:0048843)2.90592319
67urea metabolic process (GO:0019627)2.89464057
68urea cycle (GO:0000050)2.89464057
69exogenous drug catabolic process (GO:0042738)2.86634998
70ovulation cycle (GO:0042698)2.81732316
71regulation of cholesterol esterification (GO:0010872)2.81299632
72postsynaptic membrane organization (GO:0001941)2.79702503
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76097261
74C4-dicarboxylate transport (GO:0015740)2.75939218
75regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75703864
76regulation of plasminogen activation (GO:0010755)2.75571130
77glucuronate metabolic process (GO:0019585)2.74472111
78uronic acid metabolic process (GO:0006063)2.74472111
79response to gravity (GO:0009629)2.73511250
80* glutamine family amino acid catabolic process (GO:0009065)2.73449166
81bile acid metabolic process (GO:0008206)2.72647949
82tyrosine metabolic process (GO:0006570)2.72554847
83synaptic vesicle exocytosis (GO:0016079)2.71312396
84plasma lipoprotein particle remodeling (GO:0034369)2.71240128
85protein-lipid complex remodeling (GO:0034368)2.71240128
86macromolecular complex remodeling (GO:0034367)2.71240128
87short-chain fatty acid metabolic process (GO:0046459)2.70998998
88synaptic vesicle maturation (GO:0016188)2.68395062
89neurotransmitter secretion (GO:0007269)2.67944990
90peptidyl-glutamic acid carboxylation (GO:0017187)2.66914417
91protein carboxylation (GO:0018214)2.66914417
92regulation of bile acid biosynthetic process (GO:0070857)2.66793856
93collagen fibril organization (GO:0030199)2.66487298
94positive regulation of muscle hypertrophy (GO:0014742)2.66476665
95positive regulation of cardiac muscle hypertrophy (GO:0010613)2.66476665
96presynaptic membrane organization (GO:0097090)2.65762648
97epoxygenase P450 pathway (GO:0019373)2.64257231
98layer formation in cerebral cortex (GO:0021819)2.63471619
99nitrogen cycle metabolic process (GO:0071941)2.60684834
100protein heterotetramerization (GO:0051290)2.60467110
101drug transmembrane transport (GO:0006855)2.57882475
102regulation of dendritic spine morphogenesis (GO:0061001)2.57880379
103regulation of dendritic spine development (GO:0060998)2.57726371
104substrate adhesion-dependent cell spreading (GO:0034446)2.56790844
105negative regulation of sterol transport (GO:0032372)2.56168599
106negative regulation of cholesterol transport (GO:0032375)2.56168599
107neuron cell-cell adhesion (GO:0007158)2.56122612
108locomotory exploration behavior (GO:0035641)2.55799370
109regulation of Rac protein signal transduction (GO:0035020)2.55720608
110phosphate ion transport (GO:0006817)2.54421419
111dermatan sulfate biosynthetic process (GO:0030208)2.54036433
112glycine metabolic process (GO:0006544)2.53682678
113generation of neurons (GO:0048699)2.53372950
114indolalkylamine metabolic process (GO:0006586)2.53068088
115peptidyl-cysteine modification (GO:0018198)2.53007164
116regulation of cholesterol homeostasis (GO:2000188)2.52750921
117regulation of protein activation cascade (GO:2000257)2.51270994
1182-oxoglutarate metabolic process (GO:0006103)2.51239298
119amine catabolic process (GO:0009310)2.51077124
120cellular biogenic amine catabolic process (GO:0042402)2.51077124
121* organic acid catabolic process (GO:0016054)2.51063583
122* carboxylic acid catabolic process (GO:0046395)2.51063583
123acetyl-CoA metabolic process (GO:0006084)2.49352245
124glutamine family amino acid biosynthetic process (GO:0009084)2.47434211
125cell communication by electrical coupling (GO:0010644)2.47033529
126cullin deneddylation (GO:0010388)2.45705848
127regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45576690
128phosphate ion transmembrane transport (GO:0035435)2.45350687
129proline transport (GO:0015824)2.43968643
130succinate metabolic process (GO:0006105)2.43832383
131artery development (GO:0060840)2.43516083
132mesenchymal-epithelial cell signaling (GO:0060638)2.42513497
133regulation of axon guidance (GO:1902667)2.41916552
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41009382
135cell adhesion mediated by integrin (GO:0033627)2.36683030
136lymphangiogenesis (GO:0001946)2.36650325
137limb bud formation (GO:0060174)2.36090925
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.35510348
139lipid particle organization (GO:0034389)2.33834669
140regulation of synapse assembly (GO:0051963)2.33782690
141axonal fasciculation (GO:0007413)2.33594829
142regulation of protein localization to cell surface (GO:2000008)2.31628510
143intraciliary transport (GO:0042073)2.30444749
144positive regulation of fibroblast migration (GO:0010763)2.29890200
145regulation of axon extension involved in axon guidance (GO:0048841)2.29740090
146ventricular cardiac muscle cell development (GO:0055015)2.27957146
147cellular response to interferon-alpha (GO:0035457)2.26773811
148axon extension (GO:0048675)2.26469889
149neuron recognition (GO:0008038)2.23584343
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.22931504
151positive regulation of protein depolymerization (GO:1901881)2.21154023
152response to pheromone (GO:0019236)2.19951257
153protein deneddylation (GO:0000338)2.19072694
154female gonad development (GO:0008585)2.17772783
155positive regulation of vesicle fusion (GO:0031340)2.17201971
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.17116236
157negative regulation of activin receptor signaling pathway (GO:0032926)2.16847813
158regulation of cell communication by electrical coupling (GO:0010649)2.13678610
159startle response (GO:0001964)2.12872056
160positive regulation of synapse assembly (GO:0051965)2.11859752
161branched-chain amino acid catabolic process (GO:0009083)2.10932315
162regulation of keratinocyte proliferation (GO:0010837)2.10506554
163neuron projection extension (GO:1990138)2.09051240
164protein localization to cell surface (GO:0034394)2.08688972
165cholesterol biosynthetic process (GO:0006695)2.08281425
166glycosphingolipid biosynthetic process (GO:0006688)2.06552816
167neuron projection extension involved in neuron projection guidance (GO:1902284)2.05376803
168axon extension involved in axon guidance (GO:0048846)2.05376803
169regulation of neurotransmitter uptake (GO:0051580)2.03870890
170neuronal action potential propagation (GO:0019227)2.02367843
171type B pancreatic cell proliferation (GO:0044342)2.02070532
172regulation of sarcomere organization (GO:0060297)2.01822224
173cilium morphogenesis (GO:0060271)1.99800508
174sterol biosynthetic process (GO:0016126)1.99606622
175regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.98921092
176outer ear morphogenesis (GO:0042473)1.98584224
177oligodendrocyte differentiation (GO:0048709)1.98521951
178metanephric mesenchyme development (GO:0072075)1.97994517
179heart contraction (GO:0060047)1.97596938
180heart process (GO:0003015)1.97596938
181protein prenylation (GO:0018342)1.97032285
182prenylation (GO:0097354)1.97032285
183hippo signaling (GO:0035329)1.96237139
184negative regulation of keratinocyte proliferation (GO:0010839)1.96096324
185positive regulation of cardiac muscle cell differentiation (GO:2000727)1.95377469
186vagina development (GO:0060068)1.94667847
187kidney mesenchyme development (GO:0072074)1.94111034
188negative chemotaxis (GO:0050919)1.93471074
189regulation of branching involved in salivary gland morphogenesis (GO:0060693)1.93395095
190tonic smooth muscle contraction (GO:0014820)1.93232675
191vasoconstriction (GO:0042310)1.92458904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.56005403
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.26766228
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.13477746
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.06165109
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04333296
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.96035660
7GBX2_23144817_ChIP-Seq_PC3_Human2.71675706
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40927983
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.40780282
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37737479
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32429655
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24196601
13* SMAD_19615063_ChIP-ChIP_OVARY_Human2.22782784
14EZH2_22144423_ChIP-Seq_EOC_Human2.15933612
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15326503
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12868858
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07239740
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03225982
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01997495
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00200984
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00200984
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99770029
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.98775785
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96383178
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95623539
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92018151
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.91225765
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90491143
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90250182
30FUS_26573619_Chip-Seq_HEK293_Human1.89665454
31* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83721670
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82606012
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.82376380
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80403903
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73154665
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72771686
37AR_21572438_ChIP-Seq_LNCaP_Human1.71584461
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69645182
39EWS_26573619_Chip-Seq_HEK293_Human1.69551184
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69190878
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.62030108
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.61512646
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56984090
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.54417199
45REST_21632747_ChIP-Seq_MESCs_Mouse1.51153355
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48114845
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.47772455
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47766713
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.45392602
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43061307
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42270894
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42015468
53* NANOG_18555785_Chip-Seq_ESCs_Mouse1.41089119
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.40712176
55CLOCK_20551151_ChIP-Seq_293T_Human1.37474704
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37276545
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.36215855
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36036401
59TP53_16413492_ChIP-PET_HCT116_Human1.35562162
60* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34244214
61* STAT3_23295773_ChIP-Seq_U87_Human1.33809491
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33700749
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32696839
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30404914
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29931632
66IGF1R_20145208_ChIP-Seq_DFB_Human1.29656349
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.28659608
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26576832
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23940100
70TAF15_26573619_Chip-Seq_HEK293_Human1.21316982
71P53_22387025_ChIP-Seq_ESCs_Mouse1.21235518
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20887292
73* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20811463
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.20691112
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19543246
76* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19386105
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18323046
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16886569
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16676467
80ZNF274_21170338_ChIP-Seq_K562_Hela1.16542335
81* P300_19829295_ChIP-Seq_ESCs_Human1.16400454
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15534485
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.15360952
84* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15262317
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15018845
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15018845
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14927157
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14759416
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14750579
90* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13917471
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.13435239
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13135125
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13041748
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10474657
95* SOX9_26525672_Chip-Seq_HEART_Mouse1.10464015
96* DROSHA_22980978_ChIP-Seq_HELA_Human1.10307258
97CBP_20019798_ChIP-Seq_JUKART_Human1.09504589
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09504589
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09417187
100* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09267074
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.08943101
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08409620
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08254027
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.08249057
105* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08186792
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.07732873
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07208705
108CDX2_22108803_ChIP-Seq_LS180_Human1.07188034
109TCF4_22108803_ChIP-Seq_LS180_Human1.07100803
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.06621260
111* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05409101
112SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05215368
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05193861
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.05019572
115RUNX2_22187159_ChIP-Seq_PCA_Human1.03931299
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03540289
117* TCF4_23295773_ChIP-Seq_U87_Human1.03353375
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02820089
119ER_23166858_ChIP-Seq_MCF-7_Human1.02696060
120BCAT_22108803_ChIP-Seq_LS180_Human1.01799241
121RARB_27405468_Chip-Seq_BRAIN_Mouse1.01075409
122ELK1_19687146_ChIP-ChIP_HELA_Human1.01006174
123ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00664887
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00441454
125ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00213278
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.98135916
127TP53_18474530_ChIP-ChIP_U2OS_Human0.96814627
128JUN_21703547_ChIP-Seq_K562_Human0.96553968
129AR_19668381_ChIP-Seq_PC3_Human0.96372050
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96240590
131AR_25329375_ChIP-Seq_VCAP_Human0.95647129
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.95600957
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95551171
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94289362
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.94145543
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92773911
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91521720
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.90171054
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89448594
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89228713
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88210083
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.88004973
143RXR_22108803_ChIP-Seq_LS180_Human0.85290850
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83386841
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.82257293
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81961830
147HTT_18923047_ChIP-ChIP_STHdh_Human0.81720686
148CJUN_26792858_Chip-Seq_BT549_Human0.81476445
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81060180
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80562715
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80510485
152* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78422735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.14847863
2MP0002139_abnormal_hepatobiliary_system4.98692179
3MP0005085_abnormal_gallbladder_physiolo3.24891972
4MP0005365_abnormal_bile_salt3.07357503
5MP0003950_abnormal_plasma_membrane2.99171625
6MP0005623_abnormal_meninges_morphology2.89221921
7MP0006054_spinal_hemorrhage2.70065397
8MP0008875_abnormal_xenobiotic_pharmacok2.69512126
9MP0004859_abnormal_synaptic_plasticity2.54375766
10* MP0005332_abnormal_amino_acid2.46056524
11MP0003806_abnormal_nucleotide_metabolis2.32900944
12MP0004858_abnormal_nervous_system2.31191395
13MP0003252_abnormal_bile_duct2.13316119
14MP0003329_amyloid_beta_deposits2.08318008
15MP0003705_abnormal_hypodermis_morpholog2.06636033
16MP0001299_abnormal_eye_distance/1.83712581
17MP0003195_calcinosis1.80769355
18MP0008438_abnormal_cutaneous_collagen1.78943577
19MP0003635_abnormal_synaptic_transmissio1.78419338
20MP0004019_abnormal_vitamin_homeostasis1.78112259
21MP0010329_abnormal_lipoprotein_level1.75368138
22MP0000749_muscle_degeneration1.68698952
23MP0009384_cardiac_valve_regurgitation1.66723678
24MP0001958_emphysema1.65020338
25MP0002063_abnormal_learning/memory/cond1.63946026
26MP0005171_absent_coat_pigmentation1.60475968
27MP0005503_abnormal_tendon_morphology1.58795237
28MP0001968_abnormal_touch/_nociception1.47762652
29MP0009745_abnormal_behavioral_response1.47039574
30MP0002064_seizures1.46773363
31MP0009046_muscle_twitch1.44626592
32MP0003941_abnormal_skin_development1.42152573
33MP0003755_abnormal_palate_morphology1.41206490
34MP0000778_abnormal_nervous_system1.40735463
35MP0002734_abnormal_mechanical_nocicepti1.38981906
36MP0003279_aneurysm1.38302775
37MP0001984_abnormal_olfaction1.36688111
38MP0004270_analgesia1.34759878
39MP0002736_abnormal_nociception_after1.33483679
40MP0000516_abnormal_urinary_system1.33371753
41MP0005367_renal/urinary_system_phenotyp1.33371753
42MP0002822_catalepsy1.32935838
43MP0002751_abnormal_autonomic_nervous1.31984098
44MP0010386_abnormal_urinary_bladder1.31155442
45MP0005187_abnormal_penis_morphology1.31113440
46MP0002234_abnormal_pharynx_morphology1.30892678
47MP0002572_abnormal_emotion/affect_behav1.30465621
48MP0002938_white_spotting1.28934582
49MP0002102_abnormal_ear_morphology1.24721649
50MP0001529_abnormal_vocalization1.23689727
51MP0009840_abnormal_foam_cell1.22282541
52MP0009780_abnormal_chondrocyte_physiolo1.21642179
53MP0002168_other_aberrant_phenotype1.20649052
54MP0001486_abnormal_startle_reflex1.19950098
55MP0001177_atelectasis1.19747022
56MP0009697_abnormal_copulation1.19452111
57MP0003385_abnormal_body_wall1.18535973
58MP0010352_gastrointestinal_tract_polyps1.16320822
59MP0003937_abnormal_limbs/digits/tail_de1.14956427
60MP0004885_abnormal_endolymph1.14551476
61MP0003283_abnormal_digestive_organ1.14102808
62MP0000569_abnormal_digit_pigmentation1.13161375
63MP0001485_abnormal_pinna_reflex1.12400680
64MP0005248_abnormal_Harderian_gland1.11863059
65MP0000604_amyloidosis1.11160332
66MP0002233_abnormal_nose_morphology1.10569067
67MP0001346_abnormal_lacrimal_gland1.07333176
68MP0003011_delayed_dark_adaptation1.06185848
69MP0006276_abnormal_autonomic_nervous1.05757569
70MP0005646_abnormal_pituitary_gland1.05411334
71MP0000534_abnormal_ureter_morphology1.02794234
72MP0001440_abnormal_grooming_behavior1.02640995
73MP0003122_maternal_imprinting1.00887678
74MP0010368_abnormal_lymphatic_system1.00675865
75MP0005275_abnormal_skin_tensile1.00480035
76MP0003942_abnormal_urinary_system1.00452034
77MP0004272_abnormal_basement_membrane1.00207159
78MP0005584_abnormal_enzyme/coenzyme_acti0.99854746
79MP0000762_abnormal_tongue_morphology0.99484105
80MP0002733_abnormal_thermal_nociception0.99385221
81MP0002090_abnormal_vision0.99075484
82MP0009053_abnormal_anal_canal0.98882422
83MP0002067_abnormal_sensory_capabilities0.98523334
84* MP0005595_abnormal_vascular_smooth0.96753491
85MP0003868_abnormal_feces_composition0.96402513
86MP0000767_abnormal_smooth_muscle0.96362497
87MP0003880_abnormal_central_pattern0.94913222
88MP0001542_abnormal_bone_strength0.94721688
89MP0004084_abnormal_cardiac_muscle0.94328102
90MP0002118_abnormal_lipid_homeostasis0.94193328
91MP0000538_abnormal_urinary_bladder0.93376599
92MP0004133_heterotaxia0.93279966
93MP0005084_abnormal_gallbladder_morpholo0.92250989
94MP0002295_abnormal_pulmonary_circulatio0.91665090
95MP0002928_abnormal_bile_duct0.90725417
96MP0002557_abnormal_social/conspecific_i0.90565181
97MP0000613_abnormal_salivary_gland0.90024360
98MP0001293_anophthalmia0.89793716
99MP0003690_abnormal_glial_cell0.87882545
100MP0000639_abnormal_adrenal_gland0.87293192
101MP0002876_abnormal_thyroid_physiology0.87022697
102MP0003115_abnormal_respiratory_system0.86393498
103MP0005395_other_phenotype0.85613923
104MP0005551_abnormal_eye_electrophysiolog0.85612430
105MP0002108_abnormal_muscle_morphology0.85399514
106MP0004043_abnormal_pH_regulation0.85193751
107MP0002896_abnormal_bone_mineralization0.84524151
108MP0008789_abnormal_olfactory_epithelium0.84039129
109MP0002184_abnormal_innervation0.81279004
110MP0010030_abnormal_orbit_morphology0.80621594
111MP0001879_abnormal_lymphatic_vessel0.80456807
112MP0001756_abnormal_urination0.80397729
113MP0000427_abnormal_hair_cycle0.80209350
114MP0001286_abnormal_eye_development0.80204877
115MP0003935_abnormal_craniofacial_develop0.80124815
116MP0003634_abnormal_glial_cell0.79368707
117MP0000026_abnormal_inner_ear0.79336663
118MP0004233_abnormal_muscle_weight0.78832147
119MP0005508_abnormal_skeleton_morphology0.78815290
120MP0002653_abnormal_ependyma_morphology0.78137494
121MP0004883_abnormal_blood_vessel0.77788181
122MP0006072_abnormal_retinal_apoptosis0.77570466
123MP0002163_abnormal_gland_morphology0.77563668
124MP0002735_abnormal_chemical_nociception0.77505606
125MP0005319_abnormal_enzyme/_coenzyme0.76795929
126MP0005253_abnormal_eye_physiology0.76220004
127MP0001502_abnormal_circadian_rhythm0.75694311
128MP0003186_abnormal_redox_activity0.75391286
129MP0001666_abnormal_nutrient_absorption0.74974461
130MP0002837_dystrophic_cardiac_calcinosis0.74930981
131MP0009250_abnormal_appendicular_skeleto0.74775527
132MP0003632_abnormal_nervous_system0.73994607
133MP0005083_abnormal_biliary_tract0.73962968
134MP0004142_abnormal_muscle_tone0.73746830
135MP0002272_abnormal_nervous_system0.72747202
136MP0000955_abnormal_spinal_cord0.72570378
137MP0004811_abnormal_neuron_physiology0.72554592
138MP0005423_abnormal_somatic_nervous0.72232098
139MP0002066_abnormal_motor_capabilities/c0.71610512
140MP0005386_behavior/neurological_phenoty0.71606603
141MP0004924_abnormal_behavior0.71606603
142MP0001970_abnormal_pain_threshold0.69183697
143MP0002152_abnormal_brain_morphology0.68518246
144MP0002069_abnormal_eating/drinking_beha0.68276794
145MP0002882_abnormal_neuron_morphology0.67029115
146MP0006035_abnormal_mitochondrial_morpho0.65881109
147MP0002282_abnormal_trachea_morphology0.64860506
148MP0003631_nervous_system_phenotype0.64042712
149MP0002089_abnormal_postnatal_growth/wei0.63847802

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.08928866
2Xanthomatosis (HP:0000991)3.89615364
3Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78435578
4Hyperglycinemia (HP:0002154)3.67963574
5Arterial tortuosity (HP:0005116)3.66802757
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.64129195
7Aortic dissection (HP:0002647)3.60168221
8Hyperglycinuria (HP:0003108)3.50461844
9Abnormality of glycine metabolism (HP:0010895)3.49194167
10Abnormality of serine family amino acid metabolism (HP:0010894)3.49194167
11Intrahepatic cholestasis (HP:0001406)3.48139647
12Delayed gross motor development (HP:0002194)3.45890191
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.30744459
14Hypobetalipoproteinemia (HP:0003563)3.27511190
15Hyperventilation (HP:0002883)3.19352276
16Hyperammonemia (HP:0001987)3.16833037
17Gout (HP:0001997)3.14085128
18Popliteal pterygium (HP:0009756)3.03185469
19Hyperlipoproteinemia (HP:0010980)3.01353633
20Hypoalphalipoproteinemia (HP:0003233)2.88938706
21Hypolipoproteinemia (HP:0010981)2.87949153
22Megalencephaly (HP:0001355)2.86036958
23Ketosis (HP:0001946)2.83088103
24Delayed CNS myelination (HP:0002188)2.79052174
25Myokymia (HP:0002411)2.73659308
26Polyphagia (HP:0002591)2.73569259
27Protrusio acetabuli (HP:0003179)2.69269923
28Prolonged partial thromboplastin time (HP:0003645)2.65291466
29Pheochromocytoma (HP:0002666)2.57515406
30Hydroxyprolinuria (HP:0003080)2.54515200
31Abnormality of proline metabolism (HP:0010907)2.54515200
32Back pain (HP:0003418)2.54420862
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53702084
34Atonic seizures (HP:0010819)2.51191178
35Ketoacidosis (HP:0001993)2.50105134
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.49986178
37Aplasia involving bones of the extremities (HP:0009825)2.47178301
38Aplasia involving bones of the upper limbs (HP:0009823)2.47178301
39Aplasia of the phalanges of the hand (HP:0009802)2.47178301
40Soft skin (HP:0000977)2.35498533
41Abnormal eating behavior (HP:0100738)2.33061311
42Abnormality of serum amino acid levels (HP:0003112)2.32810228
43Abnormality of the ischium (HP:0003174)2.32760014
44Status epilepticus (HP:0002133)2.29662363
45Hemiparesis (HP:0001269)2.29040259
46Mitral stenosis (HP:0001718)2.28734698
47Microglossia (HP:0000171)2.27849546
48Hepatoblastoma (HP:0002884)2.27473045
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26760371
50True hermaphroditism (HP:0010459)2.25273947
51Sensorimotor neuropathy (HP:0007141)2.24016099
52Increased serum pyruvate (HP:0003542)2.23871584
53Abnormality of glycolysis (HP:0004366)2.23871584
54Amyotrophic lateral sclerosis (HP:0007354)2.22355278
55Nemaline bodies (HP:0003798)2.22201818
56Epileptic encephalopathy (HP:0200134)2.18697833
57Progressive cerebellar ataxia (HP:0002073)2.18641239
58Hypoplastic ischia (HP:0003175)2.18300564
59Epidermoid cyst (HP:0200040)2.16080783
60Abnormality of the anterior horn cell (HP:0006802)2.15941119
61Degeneration of anterior horn cells (HP:0002398)2.15941119
62Neuroendocrine neoplasm (HP:0100634)2.15641532
63Abnormal gallbladder physiology (HP:0012438)2.15167582
64Cholecystitis (HP:0001082)2.15167582
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.11861911
66Abnormality of dentin (HP:0010299)2.10986975
67Focal motor seizures (HP:0011153)2.07436205
68Hepatocellular carcinoma (HP:0001402)2.07343117
69Focal seizures (HP:0007359)2.07264293
70Pancreatic fibrosis (HP:0100732)2.05918738
71Abnormality of methionine metabolism (HP:0010901)2.04671180
72Astrocytoma (HP:0009592)2.04633280
73Abnormality of the astrocytes (HP:0100707)2.04633280
74Pterygium (HP:0001059)2.03420227
75Lethargy (HP:0001254)2.02508250
76Proximal tubulopathy (HP:0000114)2.01401092
77Premature rupture of membranes (HP:0001788)2.00397991
78Increased corneal curvature (HP:0100692)1.96941651
79Keratoconus (HP:0000563)1.96941651
80Torticollis (HP:0000473)1.95899195
81Decreased muscle mass (HP:0003199)1.95807390
82Cardiovascular calcification (HP:0011915)1.94853782
83Hyperuricemia (HP:0002149)1.94278311
84Increased purine levels (HP:0004368)1.94278311
85Abnormality of purine metabolism (HP:0004352)1.94080005
86Biconcave vertebral bodies (HP:0004586)1.93706996
87EEG with generalized epileptiform discharges (HP:0011198)1.90102901
88Aortic aneurysm (HP:0004942)1.90073158
89Vascular tortuosity (HP:0004948)1.87856931
90Drooling (HP:0002307)1.87118568
91Coronal craniosynostosis (HP:0004440)1.86102446
92Epileptiform EEG discharges (HP:0011182)1.85717608
93Hypsarrhythmia (HP:0002521)1.85095347
94Irritability (HP:0000737)1.85088893
95Short tibia (HP:0005736)1.84541362
96Poor suck (HP:0002033)1.83797066
97Long clavicles (HP:0000890)1.82587681
98Abnormality of nucleobase metabolism (HP:0010932)1.81789584
99Focal dystonia (HP:0004373)1.81753899
100Spastic diplegia (HP:0001264)1.81620571
101Chorioretinal atrophy (HP:0000533)1.81265751
102Neonatal onset (HP:0003623)1.80331782
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.79953547
104Abnormality of fatty-acid metabolism (HP:0004359)1.79324885
105Type 2 muscle fiber atrophy (HP:0003554)1.78772563
106Craniofacial dystonia (HP:0012179)1.78749737
107Neurofibrillary tangles (HP:0002185)1.78616273
108Mesomelia (HP:0003027)1.77989423
109Supernumerary spleens (HP:0009799)1.77624514
110Limited hip movement (HP:0008800)1.77624277
111Malnutrition (HP:0004395)1.76916948
112Overgrowth (HP:0001548)1.76685168
113Abnormality of the labia minora (HP:0012880)1.76651779
114Athetosis (HP:0002305)1.76181379
115Fat malabsorption (HP:0002630)1.75972065
116Volvulus (HP:0002580)1.75502060
117Neonatal short-limb short stature (HP:0008921)1.74406169
118Hypoglycemic coma (HP:0001325)1.73744713
119Complement deficiency (HP:0004431)1.73191328
120Enlarged kidneys (HP:0000105)1.73034139
121Abnormality of placental membranes (HP:0011409)1.72534439
122Amniotic constriction ring (HP:0009775)1.72534439
123Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72486691
124Spontaneous abortion (HP:0005268)1.72390062
125Metabolic acidosis (HP:0001942)1.71822162
126Gowers sign (HP:0003391)1.71657591
127Abnormality of the lower motor neuron (HP:0002366)1.70244974
128Vascular calcification (HP:0004934)1.70233394
129Cerebral inclusion bodies (HP:0100314)1.70210361
130Increased circulating renin level (HP:0000848)1.69860043
131Gaze-evoked nystagmus (HP:0000640)1.69446101
132Cerebral edema (HP:0002181)1.68722303
133Action tremor (HP:0002345)1.68171611
134Genital tract atresia (HP:0001827)1.68099031
135Spondylolisthesis (HP:0003302)1.68083073
136Alkalosis (HP:0001948)1.67628852
137Generalized tonic-clonic seizures (HP:0002069)1.67617818
138Abnormal pupillary function (HP:0007686)1.67426684
139Postaxial hand polydactyly (HP:0001162)1.66130217
140Glioma (HP:0009733)1.65543860
141Bifid tongue (HP:0010297)1.65529868
142Medial flaring of the eyebrow (HP:0010747)1.64761199
143Shallow orbits (HP:0000586)1.62617607
144Bell-shaped thorax (HP:0001591)1.62218389
145Turricephaly (HP:0000262)1.61926872
146Abnormality of macular pigmentation (HP:0008002)1.61811681
147Infantile muscular hypotonia (HP:0008947)1.61055803
148Gait imbalance (HP:0002141)1.61031911
149Renal tubular acidosis (HP:0001947)1.60865667
150Neoplasm of the peripheral nervous system (HP:0100007)1.60622441
151Camptodactyly of toe (HP:0001836)1.60258386
152Limb dystonia (HP:0002451)1.60009168
153Conjugated hyperbilirubinemia (HP:0002908)1.58189253
154Pulmonic stenosis (HP:0001642)1.57274944
155Intestinal atresia (HP:0011100)1.55510859
156Excessive salivation (HP:0003781)1.54373034
157Abnormality of the middle phalanges of the toes (HP:0010183)1.53219644
158Vaginal atresia (HP:0000148)1.52410611
159Bowel diverticulosis (HP:0005222)1.51788801
160Follicular hyperkeratosis (HP:0007502)1.50432418
161Congenital primary aphakia (HP:0007707)1.50036086
162Ependymoma (HP:0002888)1.49884866
163Febrile seizures (HP:0002373)1.49861640
164Muscle fiber inclusion bodies (HP:0100299)1.49801123
165Pancreatic cysts (HP:0001737)1.49187770
166Pulmonary artery stenosis (HP:0004415)1.47038543
167Broad metatarsal (HP:0001783)1.46945824
168Hypothermia (HP:0002045)1.46352216
169Hypoplastic scapulae (HP:0000882)1.46191294
170Aplasia/Hypoplasia of the scapulae (HP:0006713)1.46191294
171Cystic hygroma (HP:0000476)1.45586385
172Abnormality of the proximal phalanges of the hand (HP:0009834)1.45411647
173Optic nerve hypoplasia (HP:0000609)1.44810294
174Occipital encephalocele (HP:0002085)1.44557635
175Aplasia/Hypoplasia of the lens (HP:0008063)1.44045948
176Akinesia (HP:0002304)1.42742094
177Fetal akinesia sequence (HP:0001989)1.40285152
178Abnormality of midbrain morphology (HP:0002418)1.39545799
179Molar tooth sign on MRI (HP:0002419)1.39545799
180Palpebral edema (HP:0100540)1.38302558
181Nephrogenic diabetes insipidus (HP:0009806)1.38234794
182Clonus (HP:0002169)1.37478911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.51844520
2MINK12.77196436
3STK38L2.56075666
4CASK2.56024834
5MAP3K42.42506095
6LATS22.36958413
7EPHA42.28753206
8MAP2K72.24930020
9TNIK2.20522170
10NTRK22.16949110
11NEK12.10414849
12MUSK2.08441943
13PLK22.03161268
14PNCK1.98046890
15MAP2K41.92916693
16PHKG11.83580312
17PHKG21.83580312
18PRKD31.79213732
19LMTK21.77429621
20WEE11.76536856
21BCKDK1.74683415
22LIMK11.72556427
23SGK21.66103476
24TRIM281.64848626
25STK391.64629000
26WNK31.64208932
27EIF2AK31.63961434
28SGK2231.63731153
29SGK4941.63731153
30ERBB41.59802174
31MAP3K91.58366599
32PRPF4B1.57782058
33PAK61.57194838
34NUAK11.51556742
35PAK31.50734253
36MKNK21.48817899
37BRSK21.43635145
38NTRK31.42650891
39PDK31.40082018
40PDK41.40082018
41ERBB31.39086795
42AKT31.37692214
43MST41.37232026
44KSR11.29488663
45PRKCG1.27640746
46BMPR1B1.23987001
47SGK31.23600310
48PINK11.23503798
49MAP3K121.22381396
50SIK11.19069877
51TESK11.18651341
52MAP4K21.17669045
53PAK21.15795928
54FER1.15292320
55EPHB21.14911707
56CCNB11.13305993
57CDK141.07657049
58WNK41.07644996
59MAPK131.07055453
60CDK181.04710277
61DAPK21.04467038
62OXSR11.03493002
63TRIB31.01899573
64MYLK1.01800684
65CSNK1G11.01724272
66STK380.98760455
67CDK150.98218519
68STK30.95755151
69NTRK10.92667327
70BUB10.92267206
71DDR20.91163881
72ROCK10.90154724
73PTK2B0.88839498
74CDK50.87008878
75DYRK20.86214018
76CSNK1G30.86162978
77OBSCN0.82844305
78DMPK0.81686737
79PRKCZ0.81351343
80CSNK1A1L0.80333534
81STK240.80045731
82TSSK60.79846294
83CDK11A0.79757429
84CAMKK10.79301490
85GRK50.75311022
86CAMK2A0.74133333
87BRSK10.73318952
88MAP2K10.72739972
89PKN10.72688702
90EIF2AK20.70669142
91DYRK1A0.70615720
92LATS10.69865985
93SIK30.67260937
94BCR0.67136571
95FRK0.66730969
96PRKCE0.66533373
97PKN20.66526199
98ILK0.66135830
99PTK20.65627179
100PDK20.65234437
101PAK40.64920689
102TAOK20.63909615
103PIK3CA0.62946833
104PLK10.62799372
105FGFR10.61422810
106PRKCH0.60252659
107PDGFRA0.59894015
108CAMK2G0.58383844
109CSNK1G20.56453167
110ADRBK10.53417980
111PLK30.53232803
112EIF2AK10.51823634
113MKNK10.50822909
114ABL20.50740302
115ACVR1B0.50718787
116FGFR20.49703612
117RET0.49313835
118ROCK20.48721929
119GRK10.48356616
120ERBB20.47439697
121ZAK0.46999203
122BMX0.46044958
123DAPK10.44609182
124ARAF0.43506725
125MET0.42725164
126CDC42BPA0.42655109
127SGK10.42266111
128UHMK10.41711268
129NEK90.41647616
130PRKD20.41547298
131PRKACG0.39523653
132PRKCI0.39321196
133CAMK2D0.38776798
134CDK60.38525003
135CAMK2B0.38077341
136MAPK120.37729504
137TTK0.36157307
138CDK80.35402888
139TAF10.32464637
140GSK3A0.31376615

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.39737380
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.90051624
3Protein export_Homo sapiens_hsa030602.84206038
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82204769
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.80206573
6Butanoate metabolism_Homo sapiens_hsa006502.69554376
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64763978
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59626659
9Arginine biosynthesis_Homo sapiens_hsa002202.51481089
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36222137
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17819544
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14965513
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12510977
14Fatty acid degradation_Homo sapiens_hsa000712.04997528
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00386048
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97142300
17Fatty acid metabolism_Homo sapiens_hsa012121.93713222
18Propanoate metabolism_Homo sapiens_hsa006401.88076854
19Tryptophan metabolism_Homo sapiens_hsa003801.86035921
20Peroxisome_Homo sapiens_hsa041461.62239352
21Pyruvate metabolism_Homo sapiens_hsa006201.61588265
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56061213
23Biosynthesis of amino acids_Homo sapiens_hsa012301.54233898
24Bile secretion_Homo sapiens_hsa049761.49589525
25Carbon metabolism_Homo sapiens_hsa012001.48709808
26Complement and coagulation cascades_Homo sapiens_hsa046101.47107615
27PPAR signaling pathway_Homo sapiens_hsa033201.47012147
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46558474
29Synaptic vesicle cycle_Homo sapiens_hsa047211.40638509
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37524824
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28102024
32beta-Alanine metabolism_Homo sapiens_hsa004101.23974467
33Nicotine addiction_Homo sapiens_hsa050331.22555699
34GABAergic synapse_Homo sapiens_hsa047271.15651687
35Sulfur metabolism_Homo sapiens_hsa009201.15366155
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14544439
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13613638
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12868586
39Chemical carcinogenesis_Homo sapiens_hsa052041.12842546
40Steroid biosynthesis_Homo sapiens_hsa001001.10905200
41Phenylalanine metabolism_Homo sapiens_hsa003601.09588263
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09151404
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.07897401
44TGF-beta signaling pathway_Homo sapiens_hsa043501.07699096
45Non-homologous end-joining_Homo sapiens_hsa034501.04014201
46Tight junction_Homo sapiens_hsa045301.03059745
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.02895864
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00732969
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.00264302
50Arginine and proline metabolism_Homo sapiens_hsa003300.98989483
51Starch and sucrose metabolism_Homo sapiens_hsa005000.97195684
52ECM-receptor interaction_Homo sapiens_hsa045120.95172475
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95056842
54Fatty acid elongation_Homo sapiens_hsa000620.93464643
55Fatty acid biosynthesis_Homo sapiens_hsa000610.92604417
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92008805
57Circadian rhythm_Homo sapiens_hsa047100.91156592
58Oocyte meiosis_Homo sapiens_hsa041140.88010565
59Basal cell carcinoma_Homo sapiens_hsa052170.87728149
60Basal transcription factors_Homo sapiens_hsa030220.87581083
61Tyrosine metabolism_Homo sapiens_hsa003500.87138955
62Folate biosynthesis_Homo sapiens_hsa007900.86645831
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85295803
64Retinol metabolism_Homo sapiens_hsa008300.84244088
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81552316
66Phototransduction_Homo sapiens_hsa047440.80525541
67Fructose and mannose metabolism_Homo sapiens_hsa000510.79823465
68Histidine metabolism_Homo sapiens_hsa003400.78462437
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78256009
70Adherens junction_Homo sapiens_hsa045200.75713562
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.73834127
72Protein digestion and absorption_Homo sapiens_hsa049740.72205512
73Focal adhesion_Homo sapiens_hsa045100.71796579
74Collecting duct acid secretion_Homo sapiens_hsa049660.69194823
75Wnt signaling pathway_Homo sapiens_hsa043100.67732010
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67533485
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66440813
78Vitamin digestion and absorption_Homo sapiens_hsa049770.66186161
79Proteoglycans in cancer_Homo sapiens_hsa052050.65695465
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62573280
81Mineral absorption_Homo sapiens_hsa049780.61815224
82Cardiac muscle contraction_Homo sapiens_hsa042600.60462584
83Taste transduction_Homo sapiens_hsa047420.58328251
84Selenocompound metabolism_Homo sapiens_hsa004500.57665523
85Circadian entrainment_Homo sapiens_hsa047130.57012138
86Morphine addiction_Homo sapiens_hsa050320.56752544
87Glutamatergic synapse_Homo sapiens_hsa047240.56257682
88Glutathione metabolism_Homo sapiens_hsa004800.54007326
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51847300
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.51690871
91Olfactory transduction_Homo sapiens_hsa047400.51491842
92Renin secretion_Homo sapiens_hsa049240.51457855
93Vitamin B6 metabolism_Homo sapiens_hsa007500.50577040
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50146909
95Pancreatic secretion_Homo sapiens_hsa049720.49208208
96cAMP signaling pathway_Homo sapiens_hsa040240.49079361
97Fanconi anemia pathway_Homo sapiens_hsa034600.48880604
98Dopaminergic synapse_Homo sapiens_hsa047280.48129220
99Melanoma_Homo sapiens_hsa052180.47566566
100Glycerolipid metabolism_Homo sapiens_hsa005610.43958460
101Insulin secretion_Homo sapiens_hsa049110.43200609
102Pentose phosphate pathway_Homo sapiens_hsa000300.43171876
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40122340
104Galactose metabolism_Homo sapiens_hsa000520.39762173
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39258918
106Dilated cardiomyopathy_Homo sapiens_hsa054140.39157726
107Lysine degradation_Homo sapiens_hsa003100.36688480
108Cocaine addiction_Homo sapiens_hsa050300.36566801
109Glucagon signaling pathway_Homo sapiens_hsa049220.36456866
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35492935
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35411585
112Hippo signaling pathway_Homo sapiens_hsa043900.34947852
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34699463
114Metabolic pathways_Homo sapiens_hsa011000.34631958
115Amphetamine addiction_Homo sapiens_hsa050310.34219892
116Axon guidance_Homo sapiens_hsa043600.33333956
117Gap junction_Homo sapiens_hsa045400.29285240
118Thyroid hormone synthesis_Homo sapiens_hsa049180.27469967
119Salivary secretion_Homo sapiens_hsa049700.27352049
120Gastric acid secretion_Homo sapiens_hsa049710.26886473
121Oxidative phosphorylation_Homo sapiens_hsa001900.25888226
122Vibrio cholerae infection_Homo sapiens_hsa051100.25615985
123Melanogenesis_Homo sapiens_hsa049160.24875653
124Fat digestion and absorption_Homo sapiens_hsa049750.24656992
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24513048
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24404585
127Cholinergic synapse_Homo sapiens_hsa047250.24395750
128Hedgehog signaling pathway_Homo sapiens_hsa043400.24020118
129Parkinsons disease_Homo sapiens_hsa050120.23122919
130Serotonergic synapse_Homo sapiens_hsa047260.22772273
131Caffeine metabolism_Homo sapiens_hsa002320.22731194

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