DDAH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase catabolic process (GO:0046113)5.95863620
2behavioral response to nicotine (GO:0035095)5.65312311
3establishment of mitochondrion localization (GO:0051654)5.34110037
4axonal fasciculation (GO:0007413)4.59672017
5mitochondrion transport along microtubule (GO:0047497)4.55820131
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.55820131
7sequestering of actin monomers (GO:0042989)4.28448510
8paraxial mesoderm development (GO:0048339)4.26977632
9axon extension (GO:0048675)4.18232722
10neuron recognition (GO:0008038)4.12469104
11negative regulation of axon guidance (GO:1902668)3.98595458
12spinal cord association neuron differentiation (GO:0021527)3.94931788
13substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.92010662
14substrate-independent telencephalic tangential migration (GO:0021826)3.92010662
15postsynaptic membrane organization (GO:0001941)3.78450715
16dendritic spine morphogenesis (GO:0060997)3.75041641
17retinal ganglion cell axon guidance (GO:0031290)3.73990528
18peptidyl-arginine omega-N-methylation (GO:0035247)3.62566908
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60811052
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.59909701
21neuronal ion channel clustering (GO:0045161)3.58499610
22neuron projection extension (GO:1990138)3.54787438
23DNA unwinding involved in DNA replication (GO:0006268)3.53530115
24calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.52787809
25nucleosome disassembly (GO:0006337)3.52673528
26protein-DNA complex disassembly (GO:0032986)3.52673528
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49850834
28forebrain neuron differentiation (GO:0021879)3.47266579
29nonmotile primary cilium assembly (GO:0035058)3.43918539
30pyrimidine nucleobase catabolic process (GO:0006208)3.43360470
31positive regulation of mitochondrial fission (GO:0090141)3.36304180
32short-term memory (GO:0007614)3.36178836
33negative regulation of RNA splicing (GO:0033119)3.35937904
34urogenital system development (GO:0001655)3.32572069
35neurofilament cytoskeleton organization (GO:0060052)3.28781572
36peptidyl-arginine N-methylation (GO:0035246)3.28493004
37peptidyl-arginine methylation (GO:0018216)3.28493004
38cerebral cortex radially oriented cell migration (GO:0021799)3.26234072
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.25838124
40viral transcription (GO:0019083)3.24551031
41somite development (GO:0061053)3.22589381
42synaptic transmission, cholinergic (GO:0007271)3.18759642
43histone arginine methylation (GO:0034969)3.17607791
44camera-type eye morphogenesis (GO:0048593)3.16729775
45negative regulation of mRNA processing (GO:0050686)3.15005405
46dosage compensation (GO:0007549)3.13031406
47ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.12182956
48lateral sprouting from an epithelium (GO:0060601)3.09598072
49intraciliary transport (GO:0042073)3.05696851
50translational termination (GO:0006415)3.03435194
51spinal cord development (GO:0021510)3.02694870
52embryonic foregut morphogenesis (GO:0048617)3.01083270
53auditory behavior (GO:0031223)3.01055475
54synapse assembly (GO:0007416)3.00893850
55proximal/distal pattern formation (GO:0009954)3.00792934
56neuron cell-cell adhesion (GO:0007158)2.99455759
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.99308806
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99163324
59outer ear morphogenesis (GO:0042473)2.96981680
60regulation of microtubule-based movement (GO:0060632)2.96150396
61epithelial cilium movement (GO:0003351)2.95313786
62protein polyglutamylation (GO:0018095)2.95261896
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94787924
64olfactory bulb development (GO:0021772)2.94311275
65regulation of synapse structural plasticity (GO:0051823)2.88815506
66mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.88370024
67positive regulation of synapse assembly (GO:0051965)2.88152179
68presynaptic membrane organization (GO:0097090)2.85022382
69regulation of axon guidance (GO:1902667)2.83551710
70lens fiber cell development (GO:0070307)2.83224318
71axon extension involved in axon guidance (GO:0048846)2.83180043
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.83180043
73regulation of cilium movement (GO:0003352)2.80910704
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80569053
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80555433
76protein localization to synapse (GO:0035418)2.80057132
77transmission of nerve impulse (GO:0019226)2.77249810
78viral mRNA export from host cell nucleus (GO:0046784)2.76539549
79pyrimidine nucleotide catabolic process (GO:0006244)2.74762448
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.72282846
81protein localization to kinetochore (GO:0034501)2.72094759
82positive regulation of gastrulation (GO:2000543)2.71850911
83pattern specification involved in kidney development (GO:0061004)2.71330901
84cochlea morphogenesis (GO:0090103)2.70288411
85head development (GO:0060322)2.69161851
86ganglion development (GO:0061548)2.69133010
87central nervous system projection neuron axonogenesis (GO:0021952)2.68100806
88negative regulation of microtubule polymerization (GO:0031115)2.67799290
89microtubule severing (GO:0051013)2.67624168
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67573685
91translational elongation (GO:0006414)2.67410205
92negative regulation of oligodendrocyte differentiation (GO:0048715)2.66684315
93protein neddylation (GO:0045116)2.65939831
94cell differentiation in spinal cord (GO:0021515)2.65828179
95establishment of tissue polarity (GO:0007164)2.65585354
96establishment of planar polarity (GO:0001736)2.65585354
97dendrite development (GO:0016358)2.63464891
98presynaptic membrane assembly (GO:0097105)2.62428904
99telencephalon development (GO:0021537)2.61977957
100protein complex disassembly (GO:0043241)2.61307826
101DNA strand elongation involved in DNA replication (GO:0006271)2.61206188
102axonemal dynein complex assembly (GO:0070286)2.61025874
103metanephric mesenchyme development (GO:0072075)2.60669030
104specification of organ identity (GO:0010092)2.60552033
105cotranslational protein targeting to membrane (GO:0006613)2.60515790
106neuron fate determination (GO:0048664)2.59849532
107mRNA splicing, via spliceosome (GO:0000398)2.58845395
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58845395
109mechanosensory behavior (GO:0007638)2.58581513
110G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.58566366
111cell migration in hindbrain (GO:0021535)2.57582823
112negative regulation of amino acid transport (GO:0051956)2.57559814
113SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57309604
114cranial nerve morphogenesis (GO:0021602)2.56658567
115negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55975909
116negative regulation of axon extension (GO:0030517)2.55146115
117protein targeting to ER (GO:0045047)2.55006509
118RNA splicing, via transesterification reactions (GO:0000375)2.54201658
119neuronal stem cell maintenance (GO:0097150)2.53604010
120spliceosomal snRNP assembly (GO:0000387)2.53555345
121negative regulation of axonogenesis (GO:0050771)2.52117346
122cell proliferation in forebrain (GO:0021846)2.51860997
123response to misfolded protein (GO:0051788)2.51055341
124DNA damage response, detection of DNA damage (GO:0042769)2.50871362
125respiratory system process (GO:0003016)2.50719970
126kidney mesenchyme development (GO:0072074)2.49928832
127mitotic spindle assembly checkpoint (GO:0007094)2.49302377
128gastrulation with mouth forming second (GO:0001702)2.49132464
129left/right pattern formation (GO:0060972)2.49012962
130DNA strand elongation (GO:0022616)2.48927951
131translational initiation (GO:0006413)2.48890379
132negative regulation of chromosome segregation (GO:0051985)2.47009262
133cellular protein complex disassembly (GO:0043624)2.46325845
134collecting duct development (GO:0072044)2.45656093
135regulation of cellular senescence (GO:2000772)2.45470908
136ribosomal small subunit assembly (GO:0000028)2.45116180
137macromolecular complex disassembly (GO:0032984)2.45045206
138negative regulation of sister chromatid segregation (GO:0033046)2.45025776
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.45025776
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.45025776
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.45025776
142artery development (GO:0060840)2.44869240
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.44254187
144regulation of feeding behavior (GO:0060259)2.44124977
145viral life cycle (GO:0019058)2.44073279
146protein localization to endoplasmic reticulum (GO:0070972)2.43851735
147establishment of protein localization to endoplasmic reticulum (GO:0072599)2.43851451
148spindle assembly checkpoint (GO:0071173)2.43561488
149ATP synthesis coupled proton transport (GO:0015986)2.43129155
150energy coupled proton transport, down electrochemical gradient (GO:0015985)2.43129155
151notochord development (GO:0030903)2.42923149
152atrial septum morphogenesis (GO:0060413)2.42917705
153establishment or maintenance of monopolar cell polarity (GO:0061339)2.42914632
154establishment of monopolar cell polarity (GO:0061162)2.42914632
155histone H2A acetylation (GO:0043968)2.42725192
156renal system development (GO:0072001)2.42313264
157spliceosomal complex assembly (GO:0000245)2.42280594
158glial cell proliferation (GO:0014009)2.42122665
159mesenchymal cell proliferation (GO:0010463)2.37935759
160negative regulation of catenin import into nucleus (GO:0035414)2.37133322
1613-UTR-mediated mRNA stabilization (GO:0070935)2.36857901
162positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.36745870
163positive regulation of cell cycle G2/M phase transition (GO:1902751)2.36745870
164mesenchyme morphogenesis (GO:0072132)2.36628962
165lung-associated mesenchyme development (GO:0060484)2.36514370
166sister chromatid segregation (GO:0000819)2.36220791
167eyelid development in camera-type eye (GO:0061029)2.36015862
168polarized epithelial cell differentiation (GO:0030859)2.35974618
169negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.35959763
170negative regulation of mRNA metabolic process (GO:1903312)2.35770783
171cell proliferation involved in metanephros development (GO:0072203)2.35672852
172DNA replication-dependent nucleosome assembly (GO:0006335)2.35313221
173DNA replication-dependent nucleosome organization (GO:0034723)2.35313221
174microtubule depolymerization (GO:0007019)2.35116879
175mitotic spindle checkpoint (GO:0071174)2.34226299
176hippo signaling (GO:0035329)2.33717619
177regulation of hippo signaling (GO:0035330)2.32899012
178limb bud formation (GO:0060174)2.32653201
179ATP-dependent chromatin remodeling (GO:0043044)2.31516160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.36512219
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.65811993
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11362859
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.08364381
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.94357791
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.83134645
7SOX2_18555785_ChIP-Seq_MESCs_Mouse2.80181032
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.73743928
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67742549
10* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47312068
11KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.45808593
12SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45646201
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42411664
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41422019
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.38616421
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34833173
17* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31943537
18* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.27164123
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.26096254
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26007756
21* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.25082366
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.22507940
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21298886
24XRN2_22483619_ChIP-Seq_HELA_Human2.19572065
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18039546
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14753265
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11053881
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10895506
29REST_21632747_ChIP-Seq_MESCs_Mouse2.09175966
30POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04644486
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03696700
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02415065
33EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02415065
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.00130333
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98101165
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.95631191
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.92663226
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88671418
39CIITA_25753668_ChIP-Seq_RAJI_Human1.88168767
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86518543
41CTCF_27219007_Chip-Seq_Bcells_Human1.83166667
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.81617477
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73451347
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73433694
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70617136
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.70112713
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70094501
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69126000
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68109238
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67575199
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66917862
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.65799235
53TTF2_22483619_ChIP-Seq_HELA_Human1.64843378
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62072725
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54178335
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52495885
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51813337
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51114476
59RNF2_27304074_Chip-Seq_NSC_Mouse1.51045416
60* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50550867
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46441607
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44411755
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43643868
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43264195
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.43238200
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43177674
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43117313
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42605898
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41673207
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.41463999
71MYC_22102868_ChIP-Seq_BL_Human1.40680264
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40679911
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39624333
74DROSHA_22980978_ChIP-Seq_HELA_Human1.39588556
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.38843267
76* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38404104
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38347245
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.37001740
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36869714
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.36110184
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35934508
82* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35790788
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32082447
84ZNF274_21170338_ChIP-Seq_K562_Hela1.31352455
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30818088
86LXR_22292898_ChIP-Seq_THP-1_Human1.30773381
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.30319795
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30307842
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29936656
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29327771
91P68_20966046_ChIP-Seq_HELA_Human1.28601262
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28331262
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28097804
94BCL6_27268052_Chip-Seq_Bcells_Human1.27198144
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27195023
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27135173
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25328193
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24718349
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24661411
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23920904
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.23659377
102* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23221393
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22683013
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21996636
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21913798
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21302302
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.20510557
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.20296592
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19257904
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.18745453
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17758491
112AR_21909140_ChIP-Seq_LNCAP_Human1.17664705
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16935334
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16266689
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16202053
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15110671
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14704132
118* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12961693
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12506145
120IGF1R_20145208_ChIP-Seq_DFB_Human1.12114418
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12108798
122IRF1_19129219_ChIP-ChIP_H3396_Human1.11988461
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11951043
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10943543
125KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09812345
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.09785047
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.09246264
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.08085078
129* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08079263
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.06668892
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06193949
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05907417
133MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05480531
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05122045
135CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04686377
136* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04124129
137* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03677799
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03157714
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03099340
140TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02482979
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02191695
142EZH2_22144423_ChIP-Seq_EOC_Human1.01873198
143YY1_21170310_ChIP-Seq_MESCs_Mouse1.00991394
144CLOCK_20551151_ChIP-Seq_293T_Human1.00774649
145* PHF8_20622854_ChIP-Seq_HELA_Human1.00074241
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99369290
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98972462
148JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98806821
149ERA_21632823_ChIP-Seq_H3396_Human0.98727170
150* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98486926
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97932887
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97906767
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.97537587
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96549236
155SOX3_22085726_ChIP-Seq_NPCs_Mouse0.96477961
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96453690
157KDM2B_26808549_Chip-Seq_K562_Human0.96027869
158CTCF_20526341_ChIP-Seq_ESCs_Human0.95855263
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.95754400
160SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95723949
161GABP_19822575_ChIP-Seq_HepG2_Human0.95119098
162NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94253298
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.94134513
164OCT4_19829295_ChIP-Seq_ESCs_Human0.93648495
165PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93325555
166SMC4_20622854_ChIP-Seq_HELA_Human0.90150517
167* E2F1_20622854_ChIP-Seq_HELA_Human0.88906905
168TP53_22127205_ChIP-Seq_IMR90_Human0.88301969
169SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86668754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.84624659
2MP0000537_abnormal_urethra_morphology3.12993105
3MP0003787_abnormal_imprinting3.07081717
4MP0003880_abnormal_central_pattern2.66190725
5MP0008789_abnormal_olfactory_epithelium2.53426813
6MP0002822_catalepsy2.51368696
7MP0000049_abnormal_middle_ear2.49598298
8MP0005423_abnormal_somatic_nervous2.45340605
9MP0003315_abnormal_perineum_morphology2.40258258
10MP0003122_maternal_imprinting2.34465606
11MP0009053_abnormal_anal_canal2.33399188
12MP0002249_abnormal_larynx_morphology2.32979908
13MP0003385_abnormal_body_wall2.17806796
14MP0004859_abnormal_synaptic_plasticity2.10904362
15MP0003942_abnormal_urinary_system2.08945995
16MP0001529_abnormal_vocalization2.06849712
17MP0002653_abnormal_ependyma_morphology1.99810845
18MP0002938_white_spotting1.94899412
19MP0006292_abnormal_olfactory_placode1.94344082
20MP0003121_genomic_imprinting1.93464121
21MP0008007_abnormal_cellular_replicative1.90613542
22MP0003115_abnormal_respiratory_system1.89863837
23MP0000566_synostosis1.88973369
24MP0003119_abnormal_digestive_system1.88579719
25MP0005394_taste/olfaction_phenotype1.88291133
26MP0005499_abnormal_olfactory_system1.88291133
27MP0000778_abnormal_nervous_system1.87641203
28MP0003283_abnormal_digestive_organ1.86996677
29MP0003567_abnormal_fetal_cardiomyocyte1.84134562
30MP0002932_abnormal_joint_morphology1.81823426
31MP0004133_heterotaxia1.81023011
32MP0002282_abnormal_trachea_morphology1.77245689
33MP0003077_abnormal_cell_cycle1.75268086
34MP0000955_abnormal_spinal_cord1.73969227
35MP0003123_paternal_imprinting1.70639900
36MP0000534_abnormal_ureter_morphology1.67355022
37MP0002751_abnormal_autonomic_nervous1.66818614
38MP0004142_abnormal_muscle_tone1.66636657
39MP0003937_abnormal_limbs/digits/tail_de1.66350026
40MP0003935_abnormal_craniofacial_develop1.64718246
41MP0002638_abnormal_pupillary_reflex1.58364497
42MP0002557_abnormal_social/conspecific_i1.57955617
43MP0005257_abnormal_intraocular_pressure1.57353622
44MP0003755_abnormal_palate_morphology1.57219948
45MP0003111_abnormal_nucleus_morphology1.57193829
46MP0008932_abnormal_embryonic_tissue1.55686956
47MP0003861_abnormal_nervous_system1.55218325
48MP0005084_abnormal_gallbladder_morpholo1.54338533
49MP0003938_abnormal_ear_development1.53225879
50MP0003011_delayed_dark_adaptation1.52746731
51MP0010094_abnormal_chromosome_stability1.50879039
52MP0005503_abnormal_tendon_morphology1.49745290
53MP0001293_anophthalmia1.49661719
54MP0000428_abnormal_craniofacial_morphol1.49260417
55MP0002102_abnormal_ear_morphology1.48877586
56MP0001984_abnormal_olfaction1.48022805
57MP0009250_abnormal_appendicular_skeleto1.47557367
58MP0003635_abnormal_synaptic_transmissio1.47519031
59MP0003705_abnormal_hypodermis_morpholog1.46302974
60MP0002233_abnormal_nose_morphology1.46122387
61MP0002697_abnormal_eye_size1.44422876
62MP0003890_abnormal_embryonic-extraembry1.43471233
63MP0001286_abnormal_eye_development1.42496607
64MP0002085_abnormal_embryonic_tissue1.40490916
65MP0002063_abnormal_learning/memory/cond1.39966482
66MP0002882_abnormal_neuron_morphology1.39754877
67MP0002752_abnormal_somatic_nervous1.38656451
68MP0002116_abnormal_craniofacial_bone1.38506535
69MP0004272_abnormal_basement_membrane1.38200649
70MP0004197_abnormal_fetal_growth/weight/1.35654740
71MP0001968_abnormal_touch/_nociception1.32884371
72MP0002572_abnormal_emotion/affect_behav1.32361818
73MP0003693_abnormal_embryo_hatching1.30300615
74MP0002084_abnormal_developmental_patter1.29858451
75MP0000026_abnormal_inner_ear1.29415871
76MP0002234_abnormal_pharynx_morphology1.29307234
77MP0001905_abnormal_dopamine_level1.29140705
78MP0004811_abnormal_neuron_physiology1.28777271
79MP0001970_abnormal_pain_threshold1.27959555
80MP0005187_abnormal_penis_morphology1.27491288
81MP0002733_abnormal_thermal_nociception1.26691579
82MP0004742_abnormal_vestibular_system1.24092186
83MP0010368_abnormal_lymphatic_system1.23792076
84MP0004957_abnormal_blastocyst_morpholog1.22577587
85MP0008438_abnormal_cutaneous_collagen1.20067449
86MP0001485_abnormal_pinna_reflex1.18310003
87MP0005248_abnormal_Harderian_gland1.16974337
88MP0002111_abnormal_tail_morphology1.16306658
89MP0001879_abnormal_lymphatic_vessel1.14699760
90MP0000631_abnormal_neuroendocrine_gland1.13958591
91MP0002092_abnormal_eye_morphology1.13806021
92MP0002081_perinatal_lethality1.13738536
93MP0002735_abnormal_chemical_nociception1.13403196
94MP0002734_abnormal_mechanical_nocicepti1.12160822
95MP0000733_abnormal_muscle_development1.11734513
96MP0001730_embryonic_growth_arrest1.08421630
97MP0005367_renal/urinary_system_phenotyp1.08369638
98MP0000516_abnormal_urinary_system1.08369638
99MP0002272_abnormal_nervous_system1.07818530
100MP0002114_abnormal_axial_skeleton1.07309496
101MP0000350_abnormal_cell_proliferation1.06962562
102MP0001697_abnormal_embryo_size1.06933254
103MP0008058_abnormal_DNA_repair1.06461259
104MP0001188_hyperpigmentation1.04242502
105MP0005623_abnormal_meninges_morphology1.03803185
106MP0004885_abnormal_endolymph1.03651404
107MP0001672_abnormal_embryogenesis/_devel1.03648123
108MP0005380_embryogenesis_phenotype1.03648123
109MP0002067_abnormal_sensory_capabilities1.03311722
110MP0002909_abnormal_adrenal_gland1.03218315
111MP0005195_abnormal_posterior_eye1.03040051
112MP0000432_abnormal_head_morphology1.01522182
113MP0009745_abnormal_behavioral_response0.97637148
114MP0005377_hearing/vestibular/ear_phenot0.97213650
115MP0003878_abnormal_ear_physiology0.97213650
116MP0001849_ear_inflammation0.96227227
117MP0002088_abnormal_embryonic_growth/wei0.94525877
118MP0003136_yellow_coat_color0.94453650
119MP0003329_amyloid_beta_deposits0.93794710
120MP0003984_embryonic_growth_retardation0.93555185
121MP0004858_abnormal_nervous_system0.93185117
122MP0005508_abnormal_skeleton_morphology0.93123568
123MP0005551_abnormal_eye_electrophysiolog0.92752926
124MP0006276_abnormal_autonomic_nervous0.92638890
125MP0001299_abnormal_eye_distance/0.92183417
126MP0002177_abnormal_outer_ear0.91766273
127MP0001963_abnormal_hearing_physiology0.91603643
128MP0009384_cardiac_valve_regurgitation0.91205029
129MP0002184_abnormal_innervation0.89921613
130MP0004270_analgesia0.89192165
131MP0000762_abnormal_tongue_morphology0.87117328
132MP0006054_spinal_hemorrhage0.85963175
133MP0005076_abnormal_cell_differentiation0.85898882
134MP0002080_prenatal_lethality0.84888237
135MP0005083_abnormal_biliary_tract0.84876854
136MP0001486_abnormal_startle_reflex0.84481830
137MP0002152_abnormal_brain_morphology0.84068254
138MP0001270_distended_abdomen0.83849329
139MP0001440_abnormal_grooming_behavior0.83257325
140MP0002736_abnormal_nociception_after0.83105680
141MP0005645_abnormal_hypothalamus_physiol0.81848855
142MP0002925_abnormal_cardiovascular_devel0.81766338
143MP0002928_abnormal_bile_duct0.81550367
144MP0003941_abnormal_skin_development0.81160145
145MP0005391_vision/eye_phenotype0.80941881
146MP0002064_seizures0.80239957
147MP0003279_aneurysm0.80145168
148MP0004134_abnormal_chest_morphology0.79292350
149MP0004145_abnormal_muscle_electrophysio0.78831888
150MP0002109_abnormal_limb_morphology0.78117315
151MP0000467_abnormal_esophagus_morphology0.77447658
152MP0000750_abnormal_muscle_regeneration0.76570830
153MP0009379_abnormal_foot_pigmentation0.75885100
154MP0005386_behavior/neurological_phenoty0.75262659
155MP0004924_abnormal_behavior0.75262659
156MP0001502_abnormal_circadian_rhythm0.72997562
157MP0001986_abnormal_taste_sensitivity0.72503307
158MP0002066_abnormal_motor_capabilities/c0.69902826
159MP0008995_early_reproductive_senescence0.68861925

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.61080433
2Renal duplication (HP:0000075)3.95447206
3Myokymia (HP:0002411)3.94505741
4Rib fusion (HP:0000902)3.91012173
5Short 4th metacarpal (HP:0010044)3.90516014
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.90516014
7Hyperacusis (HP:0010780)3.45336106
8Gait imbalance (HP:0002141)3.36809223
9Nephronophthisis (HP:0000090)3.31594903
10Failure to thrive in infancy (HP:0001531)3.22739748
11Abnormality of the 4th metacarpal (HP:0010012)3.08691524
12Medial flaring of the eyebrow (HP:0010747)3.06555900
13Nephrogenic diabetes insipidus (HP:0009806)3.03637564
14Agitation (HP:0000713)2.97423144
15Congenital primary aphakia (HP:0007707)2.96602471
16Retinal dysplasia (HP:0007973)2.92785361
17Abnormality of the aortic arch (HP:0012303)2.91667009
18True hermaphroditism (HP:0010459)2.89348851
19Pachygyria (HP:0001302)2.86398145
20Aplasia/Hypoplasia of the brainstem (HP:0007362)2.84685964
21Hypoplasia of the brainstem (HP:0002365)2.84685964
22Molar tooth sign on MRI (HP:0002419)2.84213518
23Abnormality of midbrain morphology (HP:0002418)2.84213518
24Shallow orbits (HP:0000586)2.83239217
25Renovascular hypertension (HP:0100817)2.83078232
26Abnormality of cells of the erythroid lineage (HP:0012130)2.79468861
27Pancreatic fibrosis (HP:0100732)2.78242728
28Elfin facies (HP:0004428)2.75044341
29Cortical dysplasia (HP:0002539)2.71698727
30Overriding aorta (HP:0002623)2.70547948
31Colon cancer (HP:0003003)2.70227145
32Flat cornea (HP:0007720)2.67306238
33Adrenal hypoplasia (HP:0000835)2.61366500
34Bladder diverticulum (HP:0000015)2.60716794
35Medulloblastoma (HP:0002885)2.58008120
36Abnormal number of incisors (HP:0011064)2.57187302
37Reticulocytopenia (HP:0001896)2.55007654
38Patellar aplasia (HP:0006443)2.53140858
39Abnormal number of erythroid precursors (HP:0012131)2.52842515
40Broad alveolar ridges (HP:0000187)2.52091203
41Abnormality of the renal medulla (HP:0100957)2.51790709
42High anterior hairline (HP:0009890)2.49668192
43Abnormal eating behavior (HP:0100738)2.49263628
44Vaginal atresia (HP:0000148)2.45376236
45Abnormality of the labia minora (HP:0012880)2.45364445
46Sclerocornea (HP:0000647)2.45336170
47Aplasia/Hypoplasia of the patella (HP:0006498)2.45050912
48Wrist flexion contracture (HP:0001239)2.44919327
49Hip dysplasia (HP:0001385)2.43447689
50Increased nuchal translucency (HP:0010880)2.43209249
51Occipital encephalocele (HP:0002085)2.38073793
52Optic nerve coloboma (HP:0000588)2.36884688
53Genital tract atresia (HP:0001827)2.35323176
54Abnormal respiratory epithelium morphology (HP:0012253)2.34616159
55Abnormal respiratory motile cilium morphology (HP:0005938)2.34616159
56Pelvic girdle muscle weakness (HP:0003749)2.32735389
57Hyperglycinemia (HP:0002154)2.32224483
58Shoulder girdle muscle weakness (HP:0003547)2.31964026
59Insomnia (HP:0100785)2.31425330
60Hyperthyroidism (HP:0000836)2.27606099
61Oligomenorrhea (HP:0000876)2.27317050
62Abnormality of the diencephalon (HP:0010662)2.27166845
63Anomalous pulmonary venous return (HP:0010772)2.23998444
64Poor suck (HP:0002033)2.21465900
65Bowel diverticulosis (HP:0005222)2.19805493
66Anencephaly (HP:0002323)2.19102875
67Amblyopia (HP:0000646)2.19049512
68Bilateral microphthalmos (HP:0007633)2.19015035
69Growth hormone deficiency (HP:0000824)2.18444758
70Pancreatic cysts (HP:0001737)2.17740704
71Specific learning disability (HP:0001328)2.17727941
72Peritonitis (HP:0002586)2.14859258
73Selective tooth agenesis (HP:0001592)2.14804128
74Lissencephaly (HP:0001339)2.13791863
75Morphological abnormality of the middle ear (HP:0008609)2.12216064
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12214302
77Septo-optic dysplasia (HP:0100842)2.11147873
78Protrusio acetabuli (HP:0003179)2.11017346
79Oligodactyly (HP:0012165)2.10904887
80Acute necrotizing encephalopathy (HP:0006965)2.10626437
81Abnormal rod and cone electroretinograms (HP:0008323)2.07680835
82Mitochondrial inheritance (HP:0001427)2.05502197
83Abnormality of the musculature of the pelvis (HP:0001469)2.05362366
84Abnormality of the hip-girdle musculature (HP:0001445)2.05362366
85Sleep apnea (HP:0010535)2.04471662
86Anophthalmia (HP:0000528)2.04252266
87Abnormal mitochondria in muscle tissue (HP:0008316)2.03501153
88Drooling (HP:0002307)2.02773535
89Abnormality of the peritoneum (HP:0002585)2.00032863
90Abnormal respiratory motile cilium physiology (HP:0012261)1.99930007
91Megalocornea (HP:0000485)1.99811052
92Fetal akinesia sequence (HP:0001989)1.99354722
93Narrow forehead (HP:0000341)1.97831488
94Hepatocellular necrosis (HP:0001404)1.97156874
95Hemivertebrae (HP:0002937)1.96149971
96Cystic liver disease (HP:0006706)1.95785925
97Abnormal ciliary motility (HP:0012262)1.95380585
98Hepatoblastoma (HP:0002884)1.93843856
99Germ cell neoplasia (HP:0100728)1.93201514
100Esotropia (HP:0000565)1.93189423
101Down-sloping shoulders (HP:0200021)1.91939929
102Aplasia/Hypoplasia of the lens (HP:0008063)1.90800848
103Intestinal atresia (HP:0011100)1.90409755
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.89622692
105Trigonocephaly (HP:0000243)1.89598273
106Large eyes (HP:0001090)1.89586501
107Depressed nasal ridge (HP:0000457)1.88472156
108Spastic tetraplegia (HP:0002510)1.88257727
109Esophageal atresia (HP:0002032)1.87883908
110Flat capital femoral epiphysis (HP:0003370)1.86541244
111Chronic hepatic failure (HP:0100626)1.86457090
112Acute encephalopathy (HP:0006846)1.86354409
113Postaxial foot polydactyly (HP:0001830)1.85137951
114Polymicrogyria (HP:0002126)1.84969217
115Overlapping toe (HP:0001845)1.84887062
116Ependymoma (HP:0002888)1.84490871
117Abnormality of the pulmonary veins (HP:0011718)1.84387830
118Asymmetry of the thorax (HP:0001555)1.83483551
119Pendular nystagmus (HP:0012043)1.82731551
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.82518840
121Deviation of the hallux (HP:0010051)1.81662792
12211 pairs of ribs (HP:0000878)1.81425798
123Excessive salivation (HP:0003781)1.81342479
124Poor coordination (HP:0002370)1.81117273
125Shawl scrotum (HP:0000049)1.80077943
126Abnormal lung lobation (HP:0002101)1.79938240
127Postaxial hand polydactyly (HP:0001162)1.79872265
128Renal dysplasia (HP:0000110)1.79396035
129Patellar dislocation (HP:0002999)1.79348638
130Congenital hepatic fibrosis (HP:0002612)1.78756650
131Spina bifida occulta (HP:0003298)1.78550128
132Short 5th finger (HP:0009237)1.78211119
133Renal Fanconi syndrome (HP:0001994)1.78044357
134Bicornuate uterus (HP:0000813)1.77879897
135Hallux valgus (HP:0001822)1.77284082
136Abnormal hair whorl (HP:0010721)1.76676378
137Abnormal sex determination (HP:0012244)1.76152796
138Sex reversal (HP:0012245)1.76152796
139Midline defect of the nose (HP:0004122)1.75544019
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75305883
141Progressive sensorineural hearing impairment (HP:0000408)1.75286992
142Abnormality of the intervertebral disk (HP:0005108)1.75111040
143Atresia of the external auditory canal (HP:0000413)1.74542386
144Nephroblastoma (Wilms tumor) (HP:0002667)1.74497190
145Embryonal renal neoplasm (HP:0011794)1.74096749
146Atelectasis (HP:0100750)1.73563223
147Preaxial hand polydactyly (HP:0001177)1.72948766
148Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.72093764
149Abnormality of the lower motor neuron (HP:0002366)1.71866291
150Pointed chin (HP:0000307)1.71112465
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70239544
152Broad foot (HP:0001769)1.70217171
153Absent/shortened dynein arms (HP:0200106)1.70149698
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.70149698
155Adducted thumb (HP:0001181)1.70081163
156Supernumerary spleens (HP:0009799)1.70028139
157Abnormality of the ileum (HP:0001549)1.70011200
158Meningocele (HP:0002435)1.69781996
159Lymphangioma (HP:0100764)1.69523497
160Limb dystonia (HP:0002451)1.69241033
161Diastasis recti (HP:0001540)1.67745575
162Meckel diverticulum (HP:0002245)1.67413238
163Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.66950814
164Supernumerary ribs (HP:0005815)1.66853753
165Hypercalcemia (HP:0003072)1.66848428
166Congenital diaphragmatic hernia (HP:0000776)1.65343670
167Renal hypoplasia (HP:0000089)1.62562457
168Neoplasm of the pancreas (HP:0002894)1.62414819
169Sacral dimple (HP:0000960)1.61394358
170Short middle phalanx of the 5th finger (HP:0004220)1.60161476
171Partial duplication of the phalanx of hand (HP:0009999)1.59365087
172Proximal placement of thumb (HP:0009623)1.58788153
173Abnormality of the astrocytes (HP:0100707)1.57452810
174Astrocytoma (HP:0009592)1.57452810
175Abnormality of the carotid arteries (HP:0005344)1.54494726
176Ectopic kidney (HP:0000086)1.53546977
177Abnormality of abdominal situs (HP:0011620)1.52653776
178Abdominal situs inversus (HP:0003363)1.52653776
179Broad toe (HP:0001837)1.52355178
180Supernumerary bones of the axial skeleton (HP:0009144)1.52094414
181Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.51996714
182Tetralogy of Fallot (HP:0001636)1.51265165
183Tracheoesophageal fistula (HP:0002575)1.50624208
184Duplicated collecting system (HP:0000081)1.50381820
185Rimmed vacuoles (HP:0003805)1.49680662
186Deviation of the thumb (HP:0009603)1.49334082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.36368990
2MAP2K73.71033764
3MAP3K103.29937996
4BUB13.16317667
5BCKDK2.81082870
6CASK2.68967069
7DYRK32.62577888
8DYRK22.50089074
9MAP3K42.39218336
10MKNK12.37202971
11SRPK12.28676178
12MARK12.07460628
13CDK192.05776324
14UHMK12.04997314
15TGFBR12.02954980
16LIMK12.02741456
17TRIB32.02548861
18MAPK151.94192517
19TLK11.93807079
20EEF2K1.90337035
21ERBB31.86893084
22NEK21.80372801
23KSR11.70058306
24MKNK21.67266495
25CDC71.60645285
26RPS6KA41.56615306
27PINK11.53176460
28WEE11.52908550
29MAPK131.48507358
30TESK21.47478670
31PIM21.43541507
32PAK41.40378910
33MAP2K41.40075848
34ICK1.37939173
35MARK21.35940423
36TRIM281.33335365
37MAP4K21.33134795
38ILK1.32465893
39SIK21.31197090
40PKN21.30675234
41BRSK11.29565228
42PASK1.28313824
43DYRK1B1.28294348
44RPS6KB21.27696711
45TESK11.25725023
46CSNK1G21.25412896
47MAP2K21.24499160
48PLK31.20311347
49CDK71.20100533
50NEK11.19489235
51MAP3K61.19479392
52ERBB21.19117056
53PDGFRA1.16497792
54TIE11.15973717
55PLK11.15697423
56LATS21.15187345
57CCNB11.13608584
58AURKA1.11658002
59VRK11.07257138
60PRKCG1.05372575
61EPHA31.05200402
62ATR1.02564258
63ABL20.99798119
64ACVR1B0.99561748
65AURKB0.99295528
66NUAK10.97235881
67BCR0.96480623
68EPHA40.96002119
69DDR20.95182220
70ARAF0.94954253
71PRKD20.94310488
72CSNK1A1L0.89099876
73VRK20.86487161
74PKN10.86205325
75TYRO30.86160578
76ADRBK20.85915959
77CHEK20.85207154
78CDK40.85014307
79NTRK10.84208784
80PTK60.84134785
81CDK80.82150828
82PAK20.79445254
83DYRK1A0.78762554
84MAP3K110.76883717
85SGK4940.76805998
86SGK2230.76805998
87YES10.75310342
88CAMK10.74157825
89CDK50.73758070
90WNK40.73011179
91ADRBK10.72942589
92CSNK1G10.72053033
93PAK30.71789060
94RPS6KA20.71046033
95FGFR10.71025959
96CDK140.70734292
97MTOR0.70457287
98CDK180.70078415
99CDK60.69660185
100TSSK60.69426208
101WNK30.66062767
102NTRK30.65691290
103NME20.65497149
104CDK150.64460587
105TTK0.64314602
106ROCK10.63790827
107CDK11A0.62735838
108ROCK20.61975301
109CHEK10.61589168
110AKT20.59167328
111DAPK30.58650243
112MAPK90.58641771
113NTRK20.58464436
114PRKCZ0.57673908
115CDK10.56849341
116FGFR20.56440763
117MAP3K80.55949039
118PAK10.55356341
119CDK20.54259508
120PRKCI0.54247671
121CSNK1G30.53947530
122STK110.53690624
123RPS6KA10.52756488
124DAPK20.52103448
125BRD40.51977360
126RPS6KL10.50559593
127RPS6KC10.50559593
128PRKACA0.50303957
129IRAK20.48583882
130PRKD30.48462155
131BMPR1B0.48013782
132GRK10.47815213
133PLK40.47695332
134TAOK20.47686056
135DMPK0.47664994
136LRRK20.46649124
137CDC42BPA0.46349632
138EPHB10.46192809
139STK160.46181184
140CAMKK10.46025608
141PNCK0.44326103
142CLK10.43637188
143PRKCH0.43448868
144PRKD10.43136091
145MINK10.41108874
146BRAF0.40857334
147CSNK1A10.40806514
148CSNK1E0.40168274
149CAMK40.40156547
150KDR0.39747020
151RPS6KA60.39694049
152SIK30.37608464
153RIPK10.37556205
154TNIK0.37505434
155RPS6KA50.36598355
156ZAK0.34925112
157LMTK20.33470332
158CAMK1D0.32879805
159AKT10.32129764
160EPHA20.30928654
161SRC0.30641934

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.73050004
2DNA replication_Homo sapiens_hsa030303.44679927
3Ribosome_Homo sapiens_hsa030103.28005462
4Oxidative phosphorylation_Homo sapiens_hsa001903.21315941
5Basal cell carcinoma_Homo sapiens_hsa052173.00658247
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.95563835
7Mismatch repair_Homo sapiens_hsa034302.88557543
8Cell cycle_Homo sapiens_hsa041102.66573343
9Base excision repair_Homo sapiens_hsa034102.56430708
10Hedgehog signaling pathway_Homo sapiens_hsa043402.43487607
11Steroid biosynthesis_Homo sapiens_hsa001002.32262626
12Hippo signaling pathway_Homo sapiens_hsa043902.25697912
13Nicotine addiction_Homo sapiens_hsa050332.24967171
14RNA transport_Homo sapiens_hsa030132.17439982
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12366854
16mRNA surveillance pathway_Homo sapiens_hsa030152.12096422
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.08160725
18Notch signaling pathway_Homo sapiens_hsa043302.08027041
19Nucleotide excision repair_Homo sapiens_hsa034202.02359885
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.92561969
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89871926
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88434272
23Alzheimers disease_Homo sapiens_hsa050101.87967034
24Colorectal cancer_Homo sapiens_hsa052101.80752579
25Axon guidance_Homo sapiens_hsa043601.75999077
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65259842
27RNA polymerase_Homo sapiens_hsa030201.63644145
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61903099
29Fanconi anemia pathway_Homo sapiens_hsa034601.59017123
30Homologous recombination_Homo sapiens_hsa034401.57653370
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57454028
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55761179
33MicroRNAs in cancer_Homo sapiens_hsa052061.54808918
34Synaptic vesicle cycle_Homo sapiens_hsa047211.53118751
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46970818
36Proteasome_Homo sapiens_hsa030501.46033373
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45661011
38GABAergic synapse_Homo sapiens_hsa047271.44533125
39Phototransduction_Homo sapiens_hsa047441.42909086
40Wnt signaling pathway_Homo sapiens_hsa043101.41236315
41Morphine addiction_Homo sapiens_hsa050321.40707657
42Cocaine addiction_Homo sapiens_hsa050301.40350119
43Small cell lung cancer_Homo sapiens_hsa052221.39954967
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34266635
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32607104
46Pyrimidine metabolism_Homo sapiens_hsa002401.32138530
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31813240
48Chronic myeloid leukemia_Homo sapiens_hsa052201.30680718
49Endometrial cancer_Homo sapiens_hsa052131.30534853
50Dopaminergic synapse_Homo sapiens_hsa047281.29511024
51TGF-beta signaling pathway_Homo sapiens_hsa043501.29155115
52p53 signaling pathway_Homo sapiens_hsa041151.28960420
53Systemic lupus erythematosus_Homo sapiens_hsa053221.28481226
54Oocyte meiosis_Homo sapiens_hsa041141.22345440
55Alcoholism_Homo sapiens_hsa050341.19329174
56Bladder cancer_Homo sapiens_hsa052191.17411727
57Viral myocarditis_Homo sapiens_hsa054161.16027730
58Glutamatergic synapse_Homo sapiens_hsa047241.15983942
59Basal transcription factors_Homo sapiens_hsa030221.15135829
60Pathways in cancer_Homo sapiens_hsa052001.13149346
61HTLV-I infection_Homo sapiens_hsa051661.12633877
62Circadian entrainment_Homo sapiens_hsa047131.10807393
63Tight junction_Homo sapiens_hsa045301.09580788
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09557429
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09361254
66Peroxisome_Homo sapiens_hsa041461.07892102
67RNA degradation_Homo sapiens_hsa030181.07676808
68Butanoate metabolism_Homo sapiens_hsa006501.07386616
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07234804
70Collecting duct acid secretion_Homo sapiens_hsa049661.02889762
71Adherens junction_Homo sapiens_hsa045201.01609977
72Fatty acid elongation_Homo sapiens_hsa000620.99821192
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99056384
74Gap junction_Homo sapiens_hsa045400.97350702
75Proteoglycans in cancer_Homo sapiens_hsa052050.97103889
76ECM-receptor interaction_Homo sapiens_hsa045120.95981116
77Cholinergic synapse_Homo sapiens_hsa047250.95675451
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94002086
79Focal adhesion_Homo sapiens_hsa045100.93321235
80Melanogenesis_Homo sapiens_hsa049160.90557492
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89529825
82Epstein-Barr virus infection_Homo sapiens_hsa051690.87264619
83Vibrio cholerae infection_Homo sapiens_hsa051100.85196292
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84893226
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84630948
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84535749
87Thyroid cancer_Homo sapiens_hsa052160.84243472
88Linoleic acid metabolism_Homo sapiens_hsa005910.83936836
89Viral carcinogenesis_Homo sapiens_hsa052030.83927740
90Sulfur relay system_Homo sapiens_hsa041220.82376399
91Melanoma_Homo sapiens_hsa052180.80552413
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79901999
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.76905079
94Renal cell carcinoma_Homo sapiens_hsa052110.75525310
95Serotonergic synapse_Homo sapiens_hsa047260.73765166
96Taste transduction_Homo sapiens_hsa047420.73753272
97Propanoate metabolism_Homo sapiens_hsa006400.73223166
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72901009
99Non-small cell lung cancer_Homo sapiens_hsa052230.71058352
100N-Glycan biosynthesis_Homo sapiens_hsa005100.70776113
101Regulation of autophagy_Homo sapiens_hsa041400.70274295
102Insulin secretion_Homo sapiens_hsa049110.68905797
103One carbon pool by folate_Homo sapiens_hsa006700.68595480
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68207096
105Olfactory transduction_Homo sapiens_hsa047400.66986352
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66980846
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.64697869
108Ether lipid metabolism_Homo sapiens_hsa005650.62620135
109Prostate cancer_Homo sapiens_hsa052150.62278972
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.62192333
111Lysine degradation_Homo sapiens_hsa003100.62066082
112Protein export_Homo sapiens_hsa030600.61763063
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61432143
114Pancreatic cancer_Homo sapiens_hsa052120.61043354
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60968890
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60340074
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60110329
118Long-term depression_Homo sapiens_hsa047300.58665968
119Glioma_Homo sapiens_hsa052140.58350528
120Ras signaling pathway_Homo sapiens_hsa040140.57868943
121Metabolic pathways_Homo sapiens_hsa011000.57766744
122Arachidonic acid metabolism_Homo sapiens_hsa005900.57213387
123Fat digestion and absorption_Homo sapiens_hsa049750.57140552
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57109518
125Rap1 signaling pathway_Homo sapiens_hsa040150.56347026
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55575040
127Salmonella infection_Homo sapiens_hsa051320.55150424
128Purine metabolism_Homo sapiens_hsa002300.54277911
129Dilated cardiomyopathy_Homo sapiens_hsa054140.53807081
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53563451
131Apoptosis_Homo sapiens_hsa042100.52836065
132Huntingtons disease_Homo sapiens_hsa050160.51953525
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51805283
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.51684036
135Fatty acid metabolism_Homo sapiens_hsa012120.50651144
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50566094
137Phagosome_Homo sapiens_hsa041450.49397517
138mTOR signaling pathway_Homo sapiens_hsa041500.46855385
139Oxytocin signaling pathway_Homo sapiens_hsa049210.43759038
140Ovarian steroidogenesis_Homo sapiens_hsa049130.42692761
141Glutathione metabolism_Homo sapiens_hsa004800.42108910
142Parkinsons disease_Homo sapiens_hsa050120.41178266
143Hepatitis B_Homo sapiens_hsa051610.40560465
144Herpes simplex infection_Homo sapiens_hsa051680.40454273
145VEGF signaling pathway_Homo sapiens_hsa043700.39587274
146cAMP signaling pathway_Homo sapiens_hsa040240.38812468
147Biosynthesis of amino acids_Homo sapiens_hsa012300.37333544
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37210980
149FoxO signaling pathway_Homo sapiens_hsa040680.37038122
150Salivary secretion_Homo sapiens_hsa049700.36838259
151ErbB signaling pathway_Homo sapiens_hsa040120.35912699
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.35705340
153AMPK signaling pathway_Homo sapiens_hsa041520.34839487
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34776051
155beta-Alanine metabolism_Homo sapiens_hsa004100.33912074
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33292294
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32294633
1582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31545545
159Endocytosis_Homo sapiens_hsa041440.30296961
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30227529
161HIF-1 signaling pathway_Homo sapiens_hsa040660.28877231
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28580086
163Shigellosis_Homo sapiens_hsa051310.27923337
164Tyrosine metabolism_Homo sapiens_hsa003500.27586221
165Protein digestion and absorption_Homo sapiens_hsa049740.27196584
166Cardiac muscle contraction_Homo sapiens_hsa042600.26711591
167Insulin signaling pathway_Homo sapiens_hsa049100.26319902
168Non-homologous end-joining_Homo sapiens_hsa034500.25871830

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