DDB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.35957792
2negative T cell selection (GO:0043383)4.75485460
3negative thymic T cell selection (GO:0045060)4.43076233
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42259230
5ribosomal small subunit assembly (GO:0000028)4.36404630
6regulation of histone H3-K27 methylation (GO:0061085)4.33329068
7DNA deamination (GO:0045006)4.29960481
8regulation of gamma-delta T cell differentiation (GO:0045586)4.28118244
9positive thymic T cell selection (GO:0045059)4.19453181
10positive T cell selection (GO:0043368)4.14662878
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00918913
12negative regulation of cell killing (GO:0031342)4.00918913
13cellular response to interleukin-15 (GO:0071350)3.86721205
14regulation of gamma-delta T cell activation (GO:0046643)3.84416182
15thymic T cell selection (GO:0045061)3.82870075
16regulation of isotype switching to IgG isotypes (GO:0048302)3.79657462
17response to interleukin-15 (GO:0070672)3.74659727
18T cell selection (GO:0045058)3.73777421
19maturation of SSU-rRNA (GO:0030490)3.66318146
20DNA strand elongation involved in DNA replication (GO:0006271)3.65920919
21DNA replication initiation (GO:0006270)3.60974413
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60140180
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58987546
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58987546
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.54630660
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54630660
27telomere maintenance via semi-conservative replication (GO:0032201)3.53960322
28interferon-gamma production (GO:0032609)3.52416838
29positive regulation of granulocyte differentiation (GO:0030854)3.50328597
30cotranslational protein targeting to membrane (GO:0006613)3.49356922
31T cell receptor signaling pathway (GO:0050852)3.48420487
32protein targeting to ER (GO:0045047)3.47717465
33DNA strand elongation (GO:0022616)3.46823918
34CENP-A containing nucleosome assembly (GO:0034080)3.42934523
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40646855
36positive regulation of protein homooligomerization (GO:0032464)3.40460474
37regulation of T cell receptor signaling pathway (GO:0050856)3.31971418
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30921278
39regulation of regulatory T cell differentiation (GO:0045589)3.28919126
40DNA strand renaturation (GO:0000733)3.28810861
41protein localization to endoplasmic reticulum (GO:0070972)3.27789523
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26637930
43chromatin remodeling at centromere (GO:0031055)3.24662131
44replication fork processing (GO:0031297)3.24295677
45antigen processing and presentation of endogenous antigen (GO:0019883)3.22245356
46antigen receptor-mediated signaling pathway (GO:0050851)3.20754884
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20379864
48viral life cycle (GO:0019058)3.20174128
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19778462
50telomere maintenance via recombination (GO:0000722)3.18221611
51DNA replication checkpoint (GO:0000076)3.17782445
52DNA replication-independent nucleosome organization (GO:0034724)3.16980662
53DNA replication-independent nucleosome assembly (GO:0006336)3.16980662
54T cell migration (GO:0072678)3.16320685
55lymphocyte costimulation (GO:0031294)3.12760843
56T cell costimulation (GO:0031295)3.12528103
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.09844881
58T cell homeostasis (GO:0043029)3.09601526
59regulation of mitochondrial translation (GO:0070129)3.08184824
60translational initiation (GO:0006413)3.05220157
61NIK/NF-kappaB signaling (GO:0038061)3.04892584
62tRNA methylation (GO:0030488)3.04684928
63mitotic chromosome condensation (GO:0007076)3.02872487
64mitotic G1/S transition checkpoint (GO:0044819)3.02818151
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01182592
66leukocyte aggregation (GO:0070486)3.00271795
67ribosomal small subunit biogenesis (GO:0042274)2.98757072
68mitotic recombination (GO:0006312)2.98286585
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97722832
70telomere maintenance via telomere lengthening (GO:0010833)2.96974962
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.96040310
72mitotic metaphase plate congression (GO:0007080)2.96003521
73regulation of B cell receptor signaling pathway (GO:0050855)2.95716761
74folic acid-containing compound biosynthetic process (GO:0009396)2.95130308
75resolution of meiotic recombination intermediates (GO:0000712)2.92912826
76cellular protein complex disassembly (GO:0043624)2.89682250
77metaphase plate congression (GO:0051310)2.88282832
78T cell differentiation (GO:0030217)2.88095807
79regulation of B cell differentiation (GO:0045577)2.86878060
80mitotic G1 DNA damage checkpoint (GO:0031571)2.83998843
81positive regulation of lymphocyte apoptotic process (GO:0070230)2.83502384
82B cell receptor signaling pathway (GO:0050853)2.83279650
83ncRNA 3-end processing (GO:0043628)2.82563114
84ribonucleoprotein complex biogenesis (GO:0022613)2.82118609
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81942887
86pseudouridine synthesis (GO:0001522)2.80954373
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79834021
88DNA unwinding involved in DNA replication (GO:0006268)2.79760670
89viral transcription (GO:0019083)2.79735811
90telomere maintenance (GO:0000723)2.78123957
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75784275
92tetrahydrofolate metabolic process (GO:0046653)2.75349073
93ribosomal large subunit biogenesis (GO:0042273)2.75215207
94mast cell activation (GO:0045576)2.74631794
95protein complex biogenesis (GO:0070271)2.74251087
96telomere organization (GO:0032200)2.74206158
97regulation of isotype switching (GO:0045191)2.73799426
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.72817467
99NADH dehydrogenase complex assembly (GO:0010257)2.72817467
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72817467
101regulation of alpha-beta T cell proliferation (GO:0046640)2.72693098
102translation (GO:0006412)2.71957505
103negative regulation of DNA-templated transcription, elongation (GO:0032785)2.71410381
104translesion synthesis (GO:0019985)2.71217341
105mitochondrial respiratory chain complex assembly (GO:0033108)2.70573206
106attachment of spindle microtubules to kinetochore (GO:0008608)2.69788453
107translational termination (GO:0006415)2.69420989
108V(D)J recombination (GO:0033151)2.69223051
109establishment of chromosome localization (GO:0051303)2.68130462
110meiotic chromosome segregation (GO:0045132)2.67919304
111positive regulation of B cell differentiation (GO:0045579)2.67151549
112nuclear-transcribed mRNA catabolic process (GO:0000956)2.66183113
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66101582
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66101582
115rRNA methylation (GO:0031167)2.64866138
116positive regulation of interleukin-2 production (GO:0032743)2.64033215
117RNA methylation (GO:0001510)2.63832047
118rRNA modification (GO:0000154)2.62058317
119protein complex disassembly (GO:0043241)2.62011769
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.60339247
121protein K6-linked ubiquitination (GO:0085020)2.58890089
122cellular component biogenesis (GO:0044085)2.58853943
123somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58829116
124isotype switching (GO:0045190)2.58829116
125somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58829116
126tRNA modification (GO:0006400)2.58596635
127pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.58556154
128DNA catabolic process, exonucleolytic (GO:0000738)2.58491545
129negative regulation of telomere maintenance (GO:0032205)2.58317629
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.57808550
131T cell apoptotic process (GO:0070231)2.57651556
132transcription-coupled nucleotide-excision repair (GO:0006283)2.57550877
133antigen processing and presentation via MHC class Ib (GO:0002475)2.57386834
134mRNA catabolic process (GO:0006402)2.56626978
135histone exchange (GO:0043486)2.56281683
136rRNA processing (GO:0006364)2.56045336
137positive regulation of tolerance induction (GO:0002645)2.55510447
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54268822
139translational elongation (GO:0006414)2.53386945
140somatic cell DNA recombination (GO:0016444)2.53331040
141somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.53331040
142positive regulation of isotype switching (GO:0045830)2.52503226
143regulation of interleukin-2 biosynthetic process (GO:0045076)2.51551619
144deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.51525003
145lymphocyte homeostasis (GO:0002260)2.51002560
146glycine metabolic process (GO:0006544)2.50112824
147CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49605955
148cytidine deamination (GO:0009972)2.49343110
149cytidine metabolic process (GO:0046087)2.49343110
150cytidine catabolic process (GO:0006216)2.49343110
151viral mRNA export from host cell nucleus (GO:0046784)2.49232599
152positive regulation of T cell apoptotic process (GO:0070234)2.49107613
153T cell lineage commitment (GO:0002360)2.47836946
154rRNA metabolic process (GO:0016072)2.47101755
155kinetochore assembly (GO:0051382)2.45761339
156positive regulation of protein oligomerization (GO:0032461)2.45367574
157macromolecular complex disassembly (GO:0032984)2.45200913
158recombinational repair (GO:0000725)2.44819375
159nucleobase biosynthetic process (GO:0046112)2.44448309
160cellular response to interferon-beta (GO:0035458)2.44333723
161RNA catabolic process (GO:0006401)2.42797781
162DNA replication-dependent nucleosome assembly (GO:0006335)2.42488354
163DNA replication-dependent nucleosome organization (GO:0034723)2.42488354
164UTP biosynthetic process (GO:0006228)2.41945146
165cytochrome complex assembly (GO:0017004)2.41787812
166base-excision repair (GO:0006284)2.41412667
167vagina development (GO:0060068)2.41077711
168L-serine metabolic process (GO:0006563)2.40190295
169formation of translation preinitiation complex (GO:0001731)2.40132955
170ribosome biogenesis (GO:0042254)2.38881721
171double-strand break repair via homologous recombination (GO:0000724)2.38746163
172G1 DNA damage checkpoint (GO:0044783)2.37592271
173base-excision repair, AP site formation (GO:0006285)2.37443161
174regulation of chronic inflammatory response (GO:0002676)2.36949552
175UTP metabolic process (GO:0046051)2.35471856
176mRNA cleavage (GO:0006379)2.34946448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.64700830
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.57000391
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40593137
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16075346
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10298098
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.06939823
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.90843816
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.87267412
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.72107350
10MYC_22102868_ChIP-Seq_BL_Human2.59012051
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.58900347
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55749385
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.53733311
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.42557759
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36489262
16VDR_23849224_ChIP-Seq_CD4+_Human2.35578521
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33577032
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33522455
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33427379
20CIITA_25753668_ChIP-Seq_RAJI_Human2.33114833
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32760398
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26414297
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23766031
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15800966
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12948325
26MYB_26560356_Chip-Seq_TH2_Human2.11195280
27* NOTCH1_21737748_ChIP-Seq_TLL_Human2.09623798
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04559429
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.01638365
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01585360
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99225740
32FOXP3_21729870_ChIP-Seq_TREG_Human1.99208496
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99204530
34MYB_26560356_Chip-Seq_TH1_Human1.96222208
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.93650260
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92043011
37GATA1_22025678_ChIP-Seq_K562_Human1.91106655
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88829808
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.86743064
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85501321
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85187716
42RUNX_20019798_ChIP-Seq_JUKART_Human1.83960071
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83601839
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83087792
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79621955
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79359852
47SCL_19346495_ChIP-Seq_HPC-7_Human1.78850267
48* MAF_26560356_Chip-Seq_TH1_Human1.78670135
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.77371379
50SPI1_23547873_ChIP-Seq_NB4_Human1.75346411
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73193191
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69985731
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.69224816
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68859235
55UTX_26944678_Chip-Seq_JUKART_Human1.68601319
56XRN2_22483619_ChIP-Seq_HELA_Human1.65538072
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64042095
58VDR_21846776_ChIP-Seq_THP-1_Human1.63575659
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57881800
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57710079
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56245859
62* DCP1A_22483619_ChIP-Seq_HELA_Human1.53855351
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50817858
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50016070
65GABP_19822575_ChIP-Seq_HepG2_Human1.48924891
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47764358
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47507468
68* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46797511
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45096009
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44000747
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42820436
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41258888
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40983463
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.40861551
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.38747629
76* MAF_26560356_Chip-Seq_TH2_Human1.34416411
77KDM5A_27292631_Chip-Seq_BREAST_Human1.33791618
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31901899
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29836763
80GATA3_27048872_Chip-Seq_THYMUS_Human1.27759865
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24031434
82* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23169458
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21687178
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.20875108
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18930134
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18175206
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18091028
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16738626
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14917690
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14585500
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14558196
92* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14261714
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13734652
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13483649
95ELK1_19687146_ChIP-ChIP_HELA_Human1.13069855
96MYC_18940864_ChIP-ChIP_HL60_Human1.12891517
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12717167
98AR_21909140_ChIP-Seq_LNCAP_Human1.10990115
99* TTF2_22483619_ChIP-Seq_HELA_Human1.09768421
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.09646398
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08993117
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08123088
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07983379
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07497640
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05108846
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04063673
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03752495
108* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03051320
109* TP53_22127205_ChIP-Seq_IMR90_Human1.01900030
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00608393
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00517879
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99035668
113VDR_24763502_ChIP-Seq_THP-1_Human0.97492382
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.97026726
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96606559
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95559743
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95444616
118IRF1_19129219_ChIP-ChIP_H3396_Human0.95245960
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.94904384
120ZNF274_21170338_ChIP-Seq_K562_Hela0.94562070
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92433740
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92263728
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91905337
124TCF7_22412390_ChIP-Seq_EML_Mouse0.90713125
125GATA3_26560356_Chip-Seq_TH2_Human0.90630686
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89582096
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89506274
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.89460779
129BCL6_27268052_Chip-Seq_Bcells_Human0.84092950
130* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83883923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.85761703
2MP0005671_abnormal_response_to3.79375340
3MP0010094_abnormal_chromosome_stability3.75634675
4MP0003693_abnormal_embryo_hatching3.39004458
5MP0002396_abnormal_hematopoietic_system3.17110358
6MP0000685_abnormal_immune_system3.06354818
7MP0008058_abnormal_DNA_repair3.01304823
8MP0001835_abnormal_antigen_presentation2.84301410
9MP0002398_abnormal_bone_marrow2.69588216
10MP0001800_abnormal_humoral_immune2.62824277
11MP0002254_reproductive_system_inflammat2.54342988
12MP0003077_abnormal_cell_cycle2.53477860
13MP0008057_abnormal_DNA_replication2.51578336
14MP0001873_stomach_inflammation2.50828656
15MP0003111_abnormal_nucleus_morphology2.50769437
16MP0008877_abnormal_DNA_methylation2.47710927
17MP0002420_abnormal_adaptive_immunity2.40525122
18MP0004957_abnormal_blastocyst_morpholog2.40524105
19MP0001819_abnormal_immune_cell2.36785953
20MP0000703_abnormal_thymus_morphology2.34928369
21MP0000716_abnormal_immune_system2.23255502
22MP0001790_abnormal_immune_system2.22279848
23MP0005387_immune_system_phenotype2.22279848
24MP0000689_abnormal_spleen_morphology2.22110396
25MP0002723_abnormal_immune_serum2.20250501
26MP0002722_abnormal_immune_system2.18796155
27MP0002166_altered_tumor_susceptibility2.10897932
28MP0002452_abnormal_antigen_presenting2.10130398
29MP0009333_abnormal_splenocyte_physiolog2.08340769
30MP0003136_yellow_coat_color2.06826902
31MP0000372_irregular_coat_pigmentation2.00404127
32MP0002138_abnormal_hepatobiliary_system1.97705800
33MP0001661_extended_life_span1.96915675
34MP0002006_tumorigenesis1.94237831
35MP0002429_abnormal_blood_cell1.92920053
36MP0005000_abnormal_immune_tolerance1.90733159
37MP0003866_abnormal_defecation1.87198395
38MP0009785_altered_susceptibility_to1.80040247
39MP0009379_abnormal_foot_pigmentation1.79960449
40MP0008007_abnormal_cellular_replicative1.72857948
41MP0002102_abnormal_ear_morphology1.72522543
42MP0005025_abnormal_response_to1.69725462
43MP0004381_abnormal_hair_follicle1.64970010
44MP0010155_abnormal_intestine_physiology1.61357576
45MP0000490_abnormal_crypts_of1.57791888
46MP0005075_abnormal_melanosome_morpholog1.55608126
47MP0002405_respiratory_system_inflammati1.50632272
48MP0006082_CNS_inflammation1.47800257
49MP0003878_abnormal_ear_physiology1.45876965
50MP0005377_hearing/vestibular/ear_phenot1.45876965
51MP0004808_abnormal_hematopoietic_stem1.45251581
52MP0006035_abnormal_mitochondrial_morpho1.44749318
53* MP0002019_abnormal_tumor_incidence1.39527252
54MP0005397_hematopoietic_system_phenotyp1.34990888
55MP0001545_abnormal_hematopoietic_system1.34990888
56MP0000358_abnormal_cell_content/1.33498385
57MP0001851_eye_inflammation1.31107067
58MP0004510_myositis1.29721876
59MP0005310_abnormal_salivary_gland1.28800684
60MP0003786_premature_aging1.27876799
61MP0008875_abnormal_xenobiotic_pharmacok1.26724863
62MP0010307_abnormal_tumor_latency1.26548024
63MP0001853_heart_inflammation1.26487668
64MP0002419_abnormal_innate_immunity1.26099645
65MP0001293_anophthalmia1.25338765
66MP0003806_abnormal_nucleotide_metabolis1.24802624
67MP0001764_abnormal_homeostasis1.24143542
68MP0010030_abnormal_orbit_morphology1.24026782
69MP0000465_gastrointestinal_hemorrhage1.23231194
70MP0004947_skin_inflammation1.21840583
71MP0005389_reproductive_system_phenotype1.20694661
72MP0005174_abnormal_tail_pigmentation1.20005361
73MP0002132_abnormal_respiratory_system1.18449693
74MP0005464_abnormal_platelet_physiology1.17640982
75MP0002933_joint_inflammation1.16602843
76MP0002653_abnormal_ependyma_morphology1.16260197
77MP0002095_abnormal_skin_pigmentation1.15958886
78MP0002160_abnormal_reproductive_system1.15845201
79MP0001845_abnormal_inflammatory_respons1.09719672
80MP0002822_catalepsy1.07257144
81MP0003123_paternal_imprinting1.05841010
82MP0002139_abnormal_hepatobiliary_system1.05717664
83MP0005499_abnormal_olfactory_system1.04186995
84MP0005394_taste/olfaction_phenotype1.04186995
85MP0000371_diluted_coat_color1.02148102
86MP0002938_white_spotting1.01563226
87MP0002210_abnormal_sex_determination1.01269792
88MP0008932_abnormal_embryonic_tissue1.01213058
89* MP0000313_abnormal_cell_death1.00937479
90MP0000350_abnormal_cell_proliferation1.00663875
91MP0002148_abnormal_hypersensitivity_rea0.99695560
92MP0003724_increased_susceptibility_to0.99309656
93MP0003646_muscle_fatigue0.98630756
94MP0003186_abnormal_redox_activity0.98406330
95MP0001929_abnormal_gametogenesis0.98318261
96MP0000858_altered_metastatic_potential0.96760085
97MP0001119_abnormal_female_reproductive0.94470748
98MP0005451_abnormal_body_composition0.92941115
99MP0003787_abnormal_imprinting0.91966278
100MP0000015_abnormal_ear_pigmentation0.91071270
101MP0003436_decreased_susceptibility_to0.90227582
102MP0005058_abnormal_lysosome_morphology0.89964178
103MP0008789_abnormal_olfactory_epithelium0.87639993
104MP0005408_hypopigmentation0.86141896
105MP0000653_abnormal_sex_gland0.85421574
106MP0002075_abnormal_coat/hair_pigmentati0.84631780
107MP0003718_maternal_effect0.84202389
108MP0001697_abnormal_embryo_size0.83730789
109MP0003172_abnormal_lysosome_physiology0.82806244
110MP0002009_preneoplasia0.82360337
111MP0006292_abnormal_olfactory_placode0.81207308
112MP0001324_abnormal_eye_pigmentation0.79957163
113MP0001145_abnormal_male_reproductive0.79046996
114MP0005360_urolithiasis0.78902774
115MP0002638_abnormal_pupillary_reflex0.78831372
116MP0005220_abnormal_exocrine_pancreas0.77581428
117MP0002135_abnormal_kidney_morphology0.77070701
118MP0002277_abnormal_respiratory_mucosa0.75668342
119MP0003699_abnormal_female_reproductive0.74805676
120MP0003943_abnormal_hepatobiliary_system0.74626263
121MP0001286_abnormal_eye_development0.74382730
122MP0003890_abnormal_embryonic-extraembry0.72598180
123MP0008469_abnormal_protein_level0.69825274
124MP0002163_abnormal_gland_morphology0.68613215
125MP0001186_pigmentation_phenotype0.65840334
126MP0009765_abnormal_xenobiotic_induced0.61356548
127MP0008995_early_reproductive_senescence0.57738729
128MP0001730_embryonic_growth_arrest0.56691448
129MP0004133_heterotaxia0.55095694
130MP0005379_endocrine/exocrine_gland_phen0.54918637
131MP0002080_prenatal_lethality0.54848981
132MP0006072_abnormal_retinal_apoptosis0.53228407
133MP0001919_abnormal_reproductive_system0.52870753
134MP0001663_abnormal_digestive_system0.50486837
135MP0001502_abnormal_circadian_rhythm0.49217554
136MP0000477_abnormal_intestine_morphology0.47537242
137MP0002735_abnormal_chemical_nociception0.47298930
138* MP0002083_premature_death0.47114504
139MP0009764_decreased_sensitivity_to0.46798236

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.92550856
2Severe combined immunodeficiency (HP:0004430)4.79854620
3Abnormality of T cell number (HP:0011839)4.69158080
4Panhypogammaglobulinemia (HP:0003139)4.67643100
5Combined immunodeficiency (HP:0005387)4.46483239
6IgM deficiency (HP:0002850)4.19894173
7Abnormality of T cells (HP:0002843)4.06872582
8IgG deficiency (HP:0004315)3.89872338
9Elevated erythrocyte sedimentation rate (HP:0003565)3.89548681
10Aplastic anemia (HP:0001915)3.78795551
11* Squamous cell carcinoma (HP:0002860)3.74002538
12Birth length less than 3rd percentile (HP:0003561)3.73642788
13Abnormality of the fingertips (HP:0001211)3.70171431
14Recurrent bronchitis (HP:0002837)3.58138215
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.57849316
16Thyroiditis (HP:0100646)3.51466721
17B lymphocytopenia (HP:0010976)3.43365118
18Abnormality of B cell number (HP:0010975)3.43365118
19Type 2 muscle fiber atrophy (HP:0003554)3.31888497
20Recurrent viral infections (HP:0004429)3.30246245
21Muscle fiber atrophy (HP:0100295)3.25648897
22Agammaglobulinemia (HP:0004432)3.23736203
23Lymphopenia (HP:0001888)3.22403520
24Recurrent fungal infections (HP:0002841)3.11826036
25Chromsome breakage (HP:0040012)3.11306243
26Hypoplasia of the thymus (HP:0000778)3.08445090
27Abnormality of eosinophils (HP:0001879)3.07368649
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.05501928
29Chronic otitis media (HP:0000389)3.03963676
30Recurrent cutaneous fungal infections (HP:0011370)3.03915033
31Chronic mucocutaneous candidiasis (HP:0002728)3.03915033
32Abnormality of T cell physiology (HP:0011840)3.02910246
33Lymphoma (HP:0002665)2.99312676
34Thrombocytosis (HP:0001894)2.90405899
35Abnormality of the preputium (HP:0100587)2.82882045
36Abnormality of chromosome stability (HP:0003220)2.80290598
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79773588
38Reticulocytopenia (HP:0001896)2.75169316
39Myelodysplasia (HP:0002863)2.73864435
40Clubbing of toes (HP:0100760)2.72549347
41Abnormality of the renal collecting system (HP:0004742)2.68709794
4211 pairs of ribs (HP:0000878)2.68301053
43Abnormal number of erythroid precursors (HP:0012131)2.67339694
44Duplicated collecting system (HP:0000081)2.66006699
45Granulocytopenia (HP:0001913)2.62045593
46Leukocytosis (HP:0001974)2.61598035
47Abnormality of cells of the erythroid lineage (HP:0012130)2.61482500
48Chronic diarrhea (HP:0002028)2.61430253
49Horseshoe kidney (HP:0000085)2.58353362
50Eosinophilia (HP:0001880)2.55519028
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.51116255
52Stomatitis (HP:0010280)2.50806346
53Encephalitis (HP:0002383)2.48693545
54Meckel diverticulum (HP:0002245)2.47768322
55* Abnormality of DNA repair (HP:0003254)2.46578588
56Hypoproteinemia (HP:0003075)2.41365427
57Pancreatic cysts (HP:0001737)2.40712906
58Abnormality of the ileum (HP:0001549)2.39957939
59IgA deficiency (HP:0002720)2.39706212
60True hermaphroditism (HP:0010459)2.39230725
61Petechiae (HP:0000967)2.38858111
62Recurrent sinusitis (HP:0011108)2.38157104
63Short thumb (HP:0009778)2.37141739
64Stenosis of the external auditory canal (HP:0000402)2.36254545
65Diastasis recti (HP:0001540)2.34971126
66Neoplasm of the adrenal cortex (HP:0100641)2.33733891
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.32206884
68Pendular nystagmus (HP:0012043)2.31489758
69Autoimmune hemolytic anemia (HP:0001890)2.30417000
70Small intestinal stenosis (HP:0012848)2.29465516
71Duodenal stenosis (HP:0100867)2.29465516
72Abnormality of midbrain morphology (HP:0002418)2.29053455
73Molar tooth sign on MRI (HP:0002419)2.29053455
74Meningitis (HP:0001287)2.28052599
75Microvesicular hepatic steatosis (HP:0001414)2.27279380
76Colon cancer (HP:0003003)2.27234419
77Pancytopenia (HP:0001876)2.26642984
78Cutaneous melanoma (HP:0012056)2.25846646
79Bone marrow hypocellularity (HP:0005528)2.23828581
80Hyperglycinemia (HP:0002154)2.23294911
81Myositis (HP:0100614)2.23200609
82Carpal bone hypoplasia (HP:0001498)2.21892891
83Pancreatic fibrosis (HP:0100732)2.18490423
84Prominent nose (HP:0000448)2.17878064
85Triphalangeal thumb (HP:0001199)2.17701367
86Aplasia/Hypoplasia of the patella (HP:0006498)2.14517634
87Oral leukoplakia (HP:0002745)2.13844032
88Limb hypertonia (HP:0002509)2.11267927
89Bronchitis (HP:0012387)2.10505517
90Pallor (HP:0000980)2.10030650
91Hyperglycinuria (HP:0003108)2.09639756
92Absent thumb (HP:0009777)2.07706829
93Lipid accumulation in hepatocytes (HP:0006561)2.06288335
94Bile duct proliferation (HP:0001408)2.05192239
95Abnormal biliary tract physiology (HP:0012439)2.05192239
96Hepatocellular necrosis (HP:0001404)2.04893842
97Abnormal hair whorl (HP:0010721)2.04789341
98Acute myeloid leukemia (HP:0004808)2.03778167
99Recurrent abscess formation (HP:0002722)2.03241141
100Leukopenia (HP:0001882)2.00928608
101Increased serum lactate (HP:0002151)1.97014140
102Increased CSF lactate (HP:0002490)1.96348508
103Lip pit (HP:0100267)1.95529569
104Mitochondrial inheritance (HP:0001427)1.94267224
105Breast hypoplasia (HP:0003187)1.94016104
106Macrocytic anemia (HP:0001972)1.93921573
107Increased hepatocellular lipid droplets (HP:0006565)1.93618467
108Optic nerve coloboma (HP:0000588)1.90023042
109Pustule (HP:0200039)1.89688831
110Prolonged bleeding time (HP:0003010)1.89302723
111Sloping forehead (HP:0000340)1.89249897
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88970122
113Absent epiphyses (HP:0010577)1.88970122
114Abnormal lung lobation (HP:0002101)1.88838173
115Hypoplasia of the radius (HP:0002984)1.88325781
116Inflammation of the large intestine (HP:0002037)1.88138068
117Patellar aplasia (HP:0006443)1.87941612
118Gastrointestinal inflammation (HP:0004386)1.87926325
119Ectopic kidney (HP:0000086)1.86517676
120Microretrognathia (HP:0000308)1.86331780
121Vasculitis (HP:0002633)1.85971533
122Neutropenia (HP:0001875)1.85649597
123Abnormality of reticulocytes (HP:0004312)1.84400124
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.84391531
125Gastrointestinal stroma tumor (HP:0100723)1.83428990
126Irregular epiphyses (HP:0010582)1.83155204
127Pulmonary fibrosis (HP:0002206)1.82079536
128Amaurosis fugax (HP:0100576)1.81357458
129Mediastinal lymphadenopathy (HP:0100721)1.80872677
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.80770381
131Tubular atrophy (HP:0000092)1.80753070
132Abnormality of the carotid arteries (HP:0005344)1.80706333
133Obstructive lung disease (HP:0006536)1.80571785
134Chronic obstructive pulmonary disease (HP:0006510)1.80571785
135Nasal polyposis (HP:0100582)1.80405033
136Asplenia (HP:0001746)1.80239341
137Anophthalmia (HP:0000528)1.79977997
138* Poikiloderma (HP:0001029)1.77203747
139Abnormality of serine family amino acid metabolism (HP:0010894)1.76077530
140Abnormality of glycine metabolism (HP:0010895)1.76077530
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75929734
142Severe visual impairment (HP:0001141)1.74211313
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.73792050
144Small epiphyses (HP:0010585)1.73743066
145Recurrent skin infections (HP:0001581)1.73678458
146Abnormality of the duodenum (HP:0002246)1.72285764
147Hepatic necrosis (HP:0002605)1.71541861
148Abnormal mitochondria in muscle tissue (HP:0008316)1.71530214
149* Basal cell carcinoma (HP:0002671)1.71003628
150Congenital malformation of the right heart (HP:0011723)1.70621439
151Cystic liver disease (HP:0006706)1.69527940
152Sclerocornea (HP:0000647)1.68919251
153Enlarged kidneys (HP:0000105)1.68322570
154Cleft eyelid (HP:0000625)1.68264310
155Acute necrotizing encephalopathy (HP:0006965)1.66627563
156Rectovaginal fistula (HP:0000143)1.66378325
157Rectal fistula (HP:0100590)1.66378325
158Acute encephalopathy (HP:0006846)1.66247958
159Type I transferrin isoform profile (HP:0003642)1.66127677
160Abnormal number of incisors (HP:0011064)1.65716015
161Increased neuronal autofluorescent lipopigment (HP:0002074)1.63923367
162Nephronophthisis (HP:0000090)1.63363403
163Chronic hepatic failure (HP:0100626)1.63176184
164Abnormal protein glycosylation (HP:0012346)1.63096947
165Abnormal glycosylation (HP:0012345)1.63096947
166Abnormal protein N-linked glycosylation (HP:0012347)1.63096947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.84682759
2TXK3.82740741
3ZAK3.79118467
4VRK23.75934241
5KIT2.83261507
6NUAK12.54036212
7PIM22.52413116
8MAP3K132.49831512
9MAP2K32.47219961
10CDC72.36975085
11SMG12.35480163
12NLK2.19488752
13IKBKE2.18539651
14BCKDK2.14637541
15JAK32.14535364
16MAPKAPK32.08003263
17ITK1.97878058
18ZAP701.95379587
19ACVR1B1.93608640
20TEC1.88440937
21NEK21.82943385
22STK101.81877541
23TNIK1.81577618
24MAP3K141.80933235
25BTK1.72006823
26TAF11.71159297
27WNK41.70402303
28BUB11.69793335
29TYK21.69671309
30WEE11.64040835
31GRK61.61810755
32ADRBK21.61382683
33PDK21.59479581
34CDK81.57961121
35BRSK21.57427361
36BRD41.56358556
37EEF2K1.48688720
38VRK11.48619667
39STK161.47168474
40LCK1.43242870
41SYK1.36434004
42NME21.35419035
43BMPR1B1.31883716
44TYRO31.31607328
45MAP3K31.30394821
46CDK91.23078619
47KDR1.21441245
48EIF2AK31.18628742
49SRPK11.16584408
50BRSK11.16225700
51CHEK21.14456220
52GRK11.14270873
53TBK11.12148250
54TAOK31.12025073
55CCNB11.10776219
56CLK11.09458209
57MAP3K121.08929229
58MAP3K61.08635125
59ATR1.07436120
60FLT31.06543004
61CHUK1.03371634
62NEK91.00342771
63TNK21.00124215
64PLK10.97475276
65CDK40.95557438
66DAPK30.95509968
67FGFR40.93405511
68IRAK40.93326969
69NME10.92491871
70RPS6KA50.90456746
71PRKD20.87987892
72SGK20.87906023
73CSK0.87301617
74PASK0.85308380
75TTK0.85233047
76LYN0.84816164
77CSF1R0.84046124
78MAP2K70.83856330
79JAK10.81453959
80PRKCI0.81158804
81MST40.81130122
82MARK30.80173292
83AURKA0.76778091
84CDK120.76361640
85FGFR20.75267488
86AURKB0.75176378
87PLK40.74469919
88RPS6KB20.73054623
89EIF2AK10.72441862
90MAPK110.72225302
91NEK10.71345806
92CDK70.70946443
93HCK0.70068464
94PBK0.68501389
95MAP2K60.67437788
96CDK190.67352110
97FRK0.66536015
98MAPKAPK50.65538687
99PRKCH0.64568096
100IKBKB0.62686860
101PIK3CA0.59821730
102PRKCQ0.59816593
103DYRK1B0.59489718
104MOS0.59360155
105STK40.59245379
106MUSK0.57792891
107RAF10.56518852
108TESK20.56367160
109TGFBR10.56220440
110MKNK20.55814321
111DYRK20.54016822
112MKNK10.53731775
113CHEK10.51709680
114PKN20.49422198
115SGK30.48879852
116ATM0.47060255
117MELK0.46909429
118MAP2K20.46828192
119PIM10.45740493
120MAP3K80.44507714
121CSNK1G10.42997638
122IRAK10.42119503
123CSNK2A20.42059734
124CSNK2A10.41864029
125BMPR20.41684218
126FGFR10.41383971
127FES0.41107440
128TLK10.39398375
129CDK20.38837443
130DAPK10.38356205
131MAPKAPK20.37646515
132MAP3K90.37564545
133SIK20.36825700
134TSSK60.36576817
135LRRK20.35660356
136PLK30.35524160

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.72113079
2DNA replication_Homo sapiens_hsa030304.19265100
3Mismatch repair_Homo sapiens_hsa034303.36085568
4Base excision repair_Homo sapiens_hsa034103.00485960
5Non-homologous end-joining_Homo sapiens_hsa034502.81944425
6RNA polymerase_Homo sapiens_hsa030202.74313916
7Homologous recombination_Homo sapiens_hsa034402.72370126
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56538892
9Fanconi anemia pathway_Homo sapiens_hsa034602.53759980
10Ribosome_Homo sapiens_hsa030102.51926415
11* Nucleotide excision repair_Homo sapiens_hsa034202.39380838
12Cell cycle_Homo sapiens_hsa041102.29480172
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29333435
14Spliceosome_Homo sapiens_hsa030402.17339595
15T cell receptor signaling pathway_Homo sapiens_hsa046602.00745805
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00675208
17RNA degradation_Homo sapiens_hsa030182.00349636
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.90475497
19Pyrimidine metabolism_Homo sapiens_hsa002401.86701346
20Systemic lupus erythematosus_Homo sapiens_hsa053221.84363276
21Hematopoietic cell lineage_Homo sapiens_hsa046401.73943749
22Measles_Homo sapiens_hsa051621.72710432
23Antigen processing and presentation_Homo sapiens_hsa046121.68844572
24RNA transport_Homo sapiens_hsa030131.68351060
25Proteasome_Homo sapiens_hsa030501.66606011
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.59968596
27Herpes simplex infection_Homo sapiens_hsa051681.58476954
28Basal transcription factors_Homo sapiens_hsa030221.57623027
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48263342
30One carbon pool by folate_Homo sapiens_hsa006701.39407657
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39406398
32B cell receptor signaling pathway_Homo sapiens_hsa046621.38739862
33* p53 signaling pathway_Homo sapiens_hsa041151.36712929
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35953441
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31752251
36mRNA surveillance pathway_Homo sapiens_hsa030151.23628264
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20501193
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17871375
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17650661
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.15778242
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12683394
42Purine metabolism_Homo sapiens_hsa002301.02778151
43Steroid biosynthesis_Homo sapiens_hsa001001.02743419
44Allograft rejection_Homo sapiens_hsa053301.00690495
45Oxidative phosphorylation_Homo sapiens_hsa001900.98390132
46Epstein-Barr virus infection_Homo sapiens_hsa051690.95830776
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95721626
48Autoimmune thyroid disease_Homo sapiens_hsa053200.94744366
49Type I diabetes mellitus_Homo sapiens_hsa049400.94697823
50Graft-versus-host disease_Homo sapiens_hsa053320.91059913
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.89555133
52HTLV-I infection_Homo sapiens_hsa051660.88297693
53Fatty acid elongation_Homo sapiens_hsa000620.88260085
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87280698
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83207205
56Glutathione metabolism_Homo sapiens_hsa004800.80029386
57Influenza A_Homo sapiens_hsa051640.76850709
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76621533
59Circadian rhythm_Homo sapiens_hsa047100.74509954
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72481970
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72098188
62Peroxisome_Homo sapiens_hsa041460.71259205
63Asthma_Homo sapiens_hsa053100.70170074
64Butanoate metabolism_Homo sapiens_hsa006500.68851648
65Oocyte meiosis_Homo sapiens_hsa041140.67593249
66Leishmaniasis_Homo sapiens_hsa051400.67216754
67* Hepatitis B_Homo sapiens_hsa051610.67172036
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66699279
69Biosynthesis of amino acids_Homo sapiens_hsa012300.66480721
70Pancreatic cancer_Homo sapiens_hsa052120.66463354
71Huntingtons disease_Homo sapiens_hsa050160.65832765
72Parkinsons disease_Homo sapiens_hsa050120.65804296
73Osteoclast differentiation_Homo sapiens_hsa043800.62712375
74Tryptophan metabolism_Homo sapiens_hsa003800.62428132
75Acute myeloid leukemia_Homo sapiens_hsa052210.61092894
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60748841
77Apoptosis_Homo sapiens_hsa042100.59507066
78Staphylococcus aureus infection_Homo sapiens_hsa051500.59477253
79Folate biosynthesis_Homo sapiens_hsa007900.58998302
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58910573
81Shigellosis_Homo sapiens_hsa051310.58293080
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56362171
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56341024
84Viral carcinogenesis_Homo sapiens_hsa052030.55993029
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.55434022
86Nitrogen metabolism_Homo sapiens_hsa009100.55416006
87Pentose phosphate pathway_Homo sapiens_hsa000300.54692230
88Galactose metabolism_Homo sapiens_hsa000520.54634565
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53536782
90Metabolic pathways_Homo sapiens_hsa011000.53373878
91Pyruvate metabolism_Homo sapiens_hsa006200.52965484
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.52710133
93Chemokine signaling pathway_Homo sapiens_hsa040620.51531031
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50414780
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50056606
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48656790
97Vitamin B6 metabolism_Homo sapiens_hsa007500.48327492
98Propanoate metabolism_Homo sapiens_hsa006400.47923008
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47900012
100Colorectal cancer_Homo sapiens_hsa052100.45754909
101Viral myocarditis_Homo sapiens_hsa054160.45603697
102Lysosome_Homo sapiens_hsa041420.44444056
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43920901
104Alcoholism_Homo sapiens_hsa050340.40608884
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.40372739
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39964924
107Sulfur relay system_Homo sapiens_hsa041220.39666057
108Basal cell carcinoma_Homo sapiens_hsa052170.39367351
109Thyroid cancer_Homo sapiens_hsa052160.38567946
110Small cell lung cancer_Homo sapiens_hsa052220.38070645
111Platelet activation_Homo sapiens_hsa046110.37694581
112Toxoplasmosis_Homo sapiens_hsa051450.37205689
113Notch signaling pathway_Homo sapiens_hsa043300.37113687
114Selenocompound metabolism_Homo sapiens_hsa004500.36803352
115Non-small cell lung cancer_Homo sapiens_hsa052230.35260187
116Carbon metabolism_Homo sapiens_hsa012000.35128019
117Rheumatoid arthritis_Homo sapiens_hsa053230.35067409
118Fatty acid degradation_Homo sapiens_hsa000710.34674654
119ABC transporters_Homo sapiens_hsa020100.34260773
120Other glycan degradation_Homo sapiens_hsa005110.33833127
121N-Glycan biosynthesis_Homo sapiens_hsa005100.32560041
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31990964
123* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31127010
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30832993
125Fructose and mannose metabolism_Homo sapiens_hsa000510.29897591
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.27823227
127Choline metabolism in cancer_Homo sapiens_hsa052310.27370953
128VEGF signaling pathway_Homo sapiens_hsa043700.26581994
129Chronic myeloid leukemia_Homo sapiens_hsa052200.24832070
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24729413
131Protein export_Homo sapiens_hsa030600.24320412
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24074250
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.23875283
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23570608
135Prolactin signaling pathway_Homo sapiens_hsa049170.21759100
136Lysine degradation_Homo sapiens_hsa003100.19556833
137FoxO signaling pathway_Homo sapiens_hsa040680.18625156
138Hepatitis C_Homo sapiens_hsa051600.17217217
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17136892
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16664133
141Regulation of autophagy_Homo sapiens_hsa041400.16027584
142TNF signaling pathway_Homo sapiens_hsa046680.15288878

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