DDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)9.98368050
2* dopamine biosynthetic process (GO:0042416)9.30393590
3catecholamine transport (GO:0051937)8.21834109
4* catechol-containing compound biosynthetic process (GO:0009713)6.90175408
5* catecholamine biosynthetic process (GO:0042423)6.90175408
6angiotensin maturation (GO:0002003)6.66990645
7monoamine transport (GO:0015844)6.65911434
8epoxygenase P450 pathway (GO:0019373)6.23712779
9regulation of dopamine metabolic process (GO:0042053)5.96326359
10regulation of catecholamine metabolic process (GO:0042069)5.96326359
11* alkaloid metabolic process (GO:0009820)5.73804580
12neurotransmitter biosynthetic process (GO:0042136)5.71984933
13uronic acid metabolic process (GO:0006063)5.67722396
14glucuronate metabolic process (GO:0019585)5.67722396
15regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.65325504
16* dopamine metabolic process (GO:0042417)5.55661859
17cellular glucuronidation (GO:0052695)5.49275198
18regulation of bile acid biosynthetic process (GO:0070857)5.44521399
19neurotransmitter catabolic process (GO:0042135)5.36737472
20urea metabolic process (GO:0019627)4.88294087
21drug metabolic process (GO:0017144)4.86997624
22mating behavior (GO:0007617)4.82322094
23intestinal absorption (GO:0050892)4.81905280
24tyrosine metabolic process (GO:0006570)4.76325296
25urea cycle (GO:0000050)4.76256197
26neurotransmitter metabolic process (GO:0042133)4.73154548
27* phenol-containing compound biosynthetic process (GO:0046189)4.67109704
28drug catabolic process (GO:0042737)4.63967586
29behavioral response to nicotine (GO:0035095)4.59847097
30exogenous drug catabolic process (GO:0042738)4.53026083
31fat-soluble vitamin biosynthetic process (GO:0042362)4.38134432
32regulation of guanylate cyclase activity (GO:0031282)4.37914864
33very-low-density lipoprotein particle assembly (GO:0034379)4.33485276
34negative regulation of neurotransmitter transport (GO:0051589)4.32517620
35nitrogen cycle metabolic process (GO:0071941)4.25433469
36* toxin metabolic process (GO:0009404)4.24887556
37hormone catabolic process (GO:0042447)4.22804772
38cellular response to nicotine (GO:0071316)4.20435871
39synaptic transmission, dopaminergic (GO:0001963)4.20227837
40norepinephrine metabolic process (GO:0042415)4.19351868
41regulation of triglyceride catabolic process (GO:0010896)4.13578276
42bile acid metabolic process (GO:0008206)4.11054920
43regulation of synaptic transmission, dopaminergic (GO:0032225)4.07988150
44NADH metabolic process (GO:0006734)4.07696723
45lipoprotein transport (GO:0042953)4.07002817
46nucleobase catabolic process (GO:0046113)4.05652771
47neuron cell-cell adhesion (GO:0007158)4.00817931
48fructose metabolic process (GO:0006000)3.99326228
49* catechol-containing compound metabolic process (GO:0009712)3.98782879
50* catecholamine metabolic process (GO:0006584)3.98782879
51flavonoid metabolic process (GO:0009812)3.96551594
52response to cocaine (GO:0042220)3.95146577
53prepulse inhibition (GO:0060134)3.84623835
54synaptic transmission, cholinergic (GO:0007271)3.84414760
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83230086
56plasma lipoprotein particle assembly (GO:0034377)3.82018573
57glyoxylate metabolic process (GO:0046487)3.81511767
58regulation of oxidative phosphorylation (GO:0002082)3.79363801
59neurotransmitter uptake (GO:0001504)3.78999825
60response to corticosterone (GO:0051412)3.75202945
61regulation of neurotransmitter levels (GO:0001505)3.73789833
62arginine metabolic process (GO:0006525)3.70423412
63synaptic vesicle exocytosis (GO:0016079)3.69216377
64regulation of cholesterol esterification (GO:0010872)3.65863683
65regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.65564734
66neurotransmitter transport (GO:0006836)3.59857650
67omega-hydroxylase P450 pathway (GO:0097267)3.59661743
68diacylglycerol metabolic process (GO:0046339)3.58370851
69pyrimidine nucleobase catabolic process (GO:0006208)3.58255733
70negative regulation of cholesterol transport (GO:0032375)3.57934860
71negative regulation of sterol transport (GO:0032372)3.57934860
72behavioral response to cocaine (GO:0048148)3.56546813
73insulin secretion (GO:0030073)3.54244043
74regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.53339049
75endocrine process (GO:0050886)3.53339049
76regulation of systemic arterial blood pressure by hormone (GO:0001990)3.53339049
77vitamin biosynthetic process (GO:0009110)3.48956220
78drug transmembrane transport (GO:0006855)3.48746053
79phospholipid efflux (GO:0033700)3.47973072
80digestion (GO:0007586)3.47721987
81high-density lipoprotein particle remodeling (GO:0034375)3.46838728
82dopaminergic neuron differentiation (GO:0071542)3.45682686
83plasma lipoprotein particle remodeling (GO:0034369)3.45147488
84protein-lipid complex remodeling (GO:0034368)3.45147488
85macromolecular complex remodeling (GO:0034367)3.45147488
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.43515207
87phenylpropanoid metabolic process (GO:0009698)3.43149201
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41252619
89L-phenylalanine catabolic process (GO:0006559)3.41252619
90positive regulation of guanylate cyclase activity (GO:0031284)3.40711117
91ethanol oxidation (GO:0006069)3.34360946
92response to amphetamine (GO:0001975)3.33998072
93glutamate secretion (GO:0014047)3.31692189
94regulation of dopamine secretion (GO:0014059)3.30232546
95response to nicotine (GO:0035094)3.29828060
96response to water (GO:0009415)3.28771604
97neurotransmitter secretion (GO:0007269)3.27565740
98regulation of systemic arterial blood pressure (GO:0003073)3.25576658
99fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25253467
100behavioral response to ethanol (GO:0048149)3.25193705
101L-phenylalanine metabolic process (GO:0006558)3.24294235
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24294235
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.23205735
104* response to insecticide (GO:0017085)3.22162580
105aromatic amino acid family metabolic process (GO:0009072)3.20184655
106drug transport (GO:0015893)3.19663747
107bile acid biosynthetic process (GO:0006699)3.19579110
108protein-lipid complex assembly (GO:0065005)3.19186771
109positive regulation of lipid catabolic process (GO:0050996)3.19020872
110drinking behavior (GO:0042756)3.18086795
111cerebellar Purkinje cell layer development (GO:0021680)3.17191739
112regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.16449625
113regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.16449625
114glycoside metabolic process (GO:0016137)3.13036718
115acylglycerol homeostasis (GO:0055090)3.10119077
116triglyceride homeostasis (GO:0070328)3.10119077
117negative regulation of microtubule polymerization (GO:0031115)3.09631633
118response to mineralocorticoid (GO:0051385)3.08246755
119response to histamine (GO:0034776)3.07311244
120reverse cholesterol transport (GO:0043691)3.06442567
121neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.06057474
122protein maturation by protein folding (GO:0022417)3.05944804
123peptide hormone processing (GO:0016486)3.00082781
124cholesterol homeostasis (GO:0042632)2.99396923
125cholesterol efflux (GO:0033344)2.98964451
126regulation of cGMP biosynthetic process (GO:0030826)2.98017832
127plasma lipoprotein particle organization (GO:0071827)2.97487819
128intestinal cholesterol absorption (GO:0030299)2.96966920
129neuromuscular process controlling posture (GO:0050884)2.96477072
130renal system process involved in regulation of blood volume (GO:0001977)2.95649450
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94947525
132vitamin transmembrane transport (GO:0035461)2.94554152
133heme transport (GO:0015886)2.94506128
134sterol homeostasis (GO:0055092)2.93082553
135bile acid and bile salt transport (GO:0015721)2.90727467
136negative regulation of catecholamine secretion (GO:0033604)2.86984801
137endocrine pancreas development (GO:0031018)2.86671417
138coenzyme catabolic process (GO:0009109)2.85886684
139vitamin A metabolic process (GO:0006776)2.84810062
140regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84739000
141low-density lipoprotein particle remodeling (GO:0034374)2.84277833
142fat-soluble vitamin metabolic process (GO:0006775)2.83066800
143ethanol metabolic process (GO:0006067)2.83003138
144renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.81988742
145sulfate transmembrane transport (GO:1902358)2.80524625
146maintenance of gastrointestinal epithelium (GO:0030277)2.80520027
147lipoprotein metabolic process (GO:0042157)2.79583418
148homocysteine metabolic process (GO:0050667)2.79326795
149vitamin D metabolic process (GO:0042359)2.79051282
150membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78642752
151L-ascorbic acid metabolic process (GO:0019852)2.77913583
152regulation of protein activation cascade (GO:2000257)2.77504962
153vitamin transport (GO:0051180)2.77042408
154primary alcohol catabolic process (GO:0034310)2.75303800
155regulation of vesicle fusion (GO:0031338)2.75044145
156response to amine (GO:0014075)2.73825087
157response to iron ion (GO:0010039)2.70824670
158energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.70088427
159ATP hydrolysis coupled proton transport (GO:0015991)2.70088427
160COPI coating of Golgi vesicle (GO:0048205)2.67643888
161Golgi transport vesicle coating (GO:0048200)2.67643888
162peptide hormone secretion (GO:0030072)2.64794950
163mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63318540
164* establishment of synaptic vesicle localization (GO:0097480)2.62380081
165* synaptic vesicle transport (GO:0048489)2.62380081
166ATP synthesis coupled proton transport (GO:0015986)2.59176618
167energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59176618
168brain morphogenesis (GO:0048854)2.58633076
169neuron maturation (GO:0042551)2.57374398
170peptide secretion (GO:0002790)2.56063289
171detection of calcium ion (GO:0005513)2.55361618
172proline transport (GO:0015824)2.53569049
173enteric nervous system development (GO:0048484)2.53485085
174regulation of synaptic vesicle exocytosis (GO:2000300)2.53361569
175thalamus development (GO:0021794)2.52117052
176electron transport chain (GO:0022900)2.50894523
177intraspecies interaction between organisms (GO:0051703)2.49711102
178social behavior (GO:0035176)2.49711102
179* primary amino compound metabolic process (GO:1901160)2.49111576
180lactate metabolic process (GO:0006089)2.47060147
181respiratory electron transport chain (GO:0022904)2.46379750
182negative regulation of amine transport (GO:0051953)2.46284488
183positive regulation of exocytosis (GO:0045921)2.44308226
184dopamine transport (GO:0015872)10.1518482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.54385359
2EZH2_22144423_ChIP-Seq_EOC_Human3.70645384
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14869697
4TAF15_26573619_Chip-Seq_HEK293_Human3.03724537
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97325596
6GBX2_23144817_ChIP-Seq_PC3_Human2.88935401
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.87804975
8IGF1R_20145208_ChIP-Seq_DFB_Human2.63377976
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50504651
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40762340
11* NR3C1_23031785_ChIP-Seq_PC12_Mouse2.30704027
12REST_21632747_ChIP-Seq_MESCs_Mouse2.30502974
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30019009
14VDR_22108803_ChIP-Seq_LS180_Human2.28121757
15ZNF274_21170338_ChIP-Seq_K562_Hela2.19910412
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17875417
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17800521
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12313234
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07977220
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07400160
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03809071
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99550512
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93598694
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91000113
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.90594680
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88646776
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85924160
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84424290
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83534102
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82963263
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.80778044
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79409575
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77798492
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73147073
35* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72765271
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70527096
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.66452462
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65085922
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.64293125
40BCAT_22108803_ChIP-Seq_LS180_Human1.63966213
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63360361
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63360361
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60785967
44P300_19829295_ChIP-Seq_ESCs_Human1.60749123
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55773366
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.53278155
47SMAD4_21799915_ChIP-Seq_A2780_Human1.53222905
48GATA4_25053715_ChIP-Seq_YYC3_Human1.51594737
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48882755
50CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42890163
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41401720
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39769696
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38581226
54DROSHA_22980978_ChIP-Seq_HELA_Human1.37887526
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37844451
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.36101553
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35778211
58* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34901036
59* RXR_22158963_ChIP-Seq_LIVER_Mouse1.32223952
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30849273
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30602440
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29459626
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29393798
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.29289274
65HTT_18923047_ChIP-ChIP_STHdh_Human1.28557244
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28153809
67REST_19997604_ChIP-ChIP_NEURONS_Mouse1.26783108
68FOXA1_25552417_ChIP-Seq_VCAP_Human1.26567580
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24878481
70* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24841285
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24595568
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21854305
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20226343
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19660752
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18962763
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.18857167
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.17723781
78* STAT3_23295773_ChIP-Seq_U87_Human1.15888525
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15749387
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.08402501
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07872299
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07842483
83RUNX2_22187159_ChIP-Seq_PCA_Human1.07770582
84AR_25329375_ChIP-Seq_VCAP_Human1.07490563
85GATA6_25053715_ChIP-Seq_YYC3_Human1.05912331
86* LXR_22158963_ChIP-Seq_LIVER_Mouse1.05577455
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.04156165
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.03973315
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03355734
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03288701
91RXR_22108803_ChIP-Seq_LS180_Human1.03114729
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03079679
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00770035
94* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00190070
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99185371
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98319089
97GATA1_22025678_ChIP-Seq_K562_Human0.97641509
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97532388
99SOX2_20726797_ChIP-Seq_SW620_Human0.97506432
100* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97190665
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97091328
102TCF4_23295773_ChIP-Seq_U87_Human0.96689464
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96396172
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96254028
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94970194
106KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94300743
107FUS_26573619_Chip-Seq_HEK293_Human0.93699072
108CTCF_27219007_Chip-Seq_Bcells_Human0.93605060
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93601986
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92783102
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92175690
112JUN_21703547_ChIP-Seq_K562_Human0.92143615
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91227099
114RNF2_27304074_Chip-Seq_NSC_Mouse0.91083025
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91033379
116* RARB_27405468_Chip-Seq_BRAIN_Mouse0.90193476
117* FLI1_21867929_ChIP-Seq_TH2_Mouse0.90160689
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89839890
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89549240
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88971857
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88839520
122* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87794623
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86910746
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.86715478
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.86570649
126* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85511263
127* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85154822
128TCF4_22108803_ChIP-Seq_LS180_Human0.85025333
129* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84097324
130CDX2_22108803_ChIP-Seq_LS180_Human0.83921483
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.83677002
132ER_23166858_ChIP-Seq_MCF-7_Human0.83249321
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81464938
134KDM2B_26808549_Chip-Seq_REH_Human0.80996220
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80069041
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.79406603
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.78409573
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78375182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.71777067
2MP0001905_abnormal_dopamine_level4.55908180
3MP0002822_catalepsy4.41805245
4MP0006276_abnormal_autonomic_nervous4.01241947
5MP0001529_abnormal_vocalization3.19682039
6MP0002909_abnormal_adrenal_gland3.11463755
7MP0004019_abnormal_vitamin_homeostasis3.01125153
8MP0001501_abnormal_sleep_pattern2.88134955
9MP0003122_maternal_imprinting2.76224483
10MP0010386_abnormal_urinary_bladder2.63177837
11MP0009379_abnormal_foot_pigmentation2.58280105
12MP0003880_abnormal_central_pattern2.41546397
13MP0010329_abnormal_lipoprotein_level2.39363338
14MP0002837_dystrophic_cardiac_calcinosis2.38711736
15MP0002638_abnormal_pupillary_reflex2.36964887
16MP0002733_abnormal_thermal_nociception2.25758637
17MP0005535_abnormal_body_temperature2.24400250
18MP0000566_synostosis2.21468991
19MP0003011_delayed_dark_adaptation2.06519131
20MP0004924_abnormal_behavior2.01208441
21MP0005386_behavior/neurological_phenoty2.01208441
22MP0004264_abnormal_extraembryonic_tissu1.99158625
23MP0003635_abnormal_synaptic_transmissio1.94310672
24MP0003195_calcinosis1.93470823
25MP0005379_endocrine/exocrine_gland_phen1.91562146
26MP0000538_abnormal_urinary_bladder1.88355001
27MP0002572_abnormal_emotion/affect_behav1.86072073
28MP0005646_abnormal_pituitary_gland1.80332226
29MP0003868_abnormal_feces_composition1.76048955
30MP0009840_abnormal_foam_cell1.73540869
31MP0004270_analgesia1.72074394
32MP0009046_muscle_twitch1.72033412
33MP0000013_abnormal_adipose_tissue1.71512816
34MP0003283_abnormal_digestive_organ1.70828103
35MP0009745_abnormal_behavioral_response1.70666631
36MP0004859_abnormal_synaptic_plasticity1.69320686
37MP0005085_abnormal_gallbladder_physiolo1.69166906
38MP0005360_urolithiasis1.68347586
39MP0002693_abnormal_pancreas_physiology1.62679782
40MP0002064_seizures1.60484663
41MP0004147_increased_porphyrin_level1.60131563
42MP0002272_abnormal_nervous_system1.57611365
43MP0001440_abnormal_grooming_behavior1.54714678
44MP0009780_abnormal_chondrocyte_physiolo1.53136808
45MP0003183_abnormal_peptide_metabolism1.52105705
46MP0004043_abnormal_pH_regulation1.51431063
47MP0002063_abnormal_learning/memory/cond1.45875781
48MP0008872_abnormal_physiological_respon1.45182609
49MP0002734_abnormal_mechanical_nocicepti1.43262414
50MP0001970_abnormal_pain_threshold1.41823166
51MP0001188_hyperpigmentation1.40914720
52MP0009643_abnormal_urine_homeostasis1.39978616
53MP0002557_abnormal_social/conspecific_i1.36858279
54MP0005365_abnormal_bile_salt1.36564521
55MP0001944_abnormal_pancreas_morphology1.36005492
56MP0001764_abnormal_homeostasis1.33219310
57MP0003879_abnormal_hair_cell1.31698766
58MP0005409_darkened_coat_color1.31468757
59MP0008875_abnormal_xenobiotic_pharmacok1.31039099
60MP0005248_abnormal_Harderian_gland1.30946628
61MP0003890_abnormal_embryonic-extraembry1.25742733
62MP0005645_abnormal_hypothalamus_physiol1.25644330
63MP0001486_abnormal_startle_reflex1.25257771
64MP0002751_abnormal_autonomic_nervous1.23148881
65MP0000639_abnormal_adrenal_gland1.19553933
66MP0001666_abnormal_nutrient_absorption1.18752887
67MP0002067_abnormal_sensory_capabilities1.17126348
68MP0002163_abnormal_gland_morphology1.15997798
69MP0002184_abnormal_innervation1.13302374
70MP0001664_abnormal_digestion1.12905576
71MP0003123_paternal_imprinting1.10041734
72MP0003252_abnormal_bile_duct1.09495023
73MP0002078_abnormal_glucose_homeostasis1.08818488
74MP0003718_maternal_effect1.06771006
75MP0005423_abnormal_somatic_nervous1.05078644
76MP0005220_abnormal_exocrine_pancreas1.03392818
77MP0000631_abnormal_neuroendocrine_gland1.02962208
78MP0006072_abnormal_retinal_apoptosis1.02828647
79MP0003953_abnormal_hormone_level1.01625281
80MP0002138_abnormal_hepatobiliary_system1.01293884
81MP0004142_abnormal_muscle_tone1.00242848
82MP0005083_abnormal_biliary_tract0.98160666
83MP0004858_abnormal_nervous_system0.97354390
84MP0001485_abnormal_pinna_reflex0.93799371
85MP0003121_genomic_imprinting0.93398040
86MP0002877_abnormal_melanocyte_morpholog0.93254058
87MP0001502_abnormal_circadian_rhythm0.92675304
88MP0005670_abnormal_white_adipose0.92294516
89MP0002066_abnormal_motor_capabilities/c0.92097168
90MP0002090_abnormal_vision0.90810862
91MP0000569_abnormal_digit_pigmentation0.89898302
92MP0000462_abnormal_digestive_system0.87889155
93MP0003329_amyloid_beta_deposits0.87607215
94MP0001968_abnormal_touch/_nociception0.87396773
95MP0000609_abnormal_liver_physiology0.87031707
96MP0002876_abnormal_thyroid_physiology0.85800806
97MP0003632_abnormal_nervous_system0.83651029
98MP0000955_abnormal_spinal_cord0.82022040
99MP0003315_abnormal_perineum_morphology0.80870377
100MP0004742_abnormal_vestibular_system0.79784980
101MP0002069_abnormal_eating/drinking_beha0.78507453
102MP0001765_abnormal_ion_homeostasis0.77121881
103MP0003959_abnormal_lean_body0.76214590
104MP0005187_abnormal_penis_morphology0.75277490
105MP0005332_abnormal_amino_acid0.75122418
106MP0004133_heterotaxia0.74377762
107MP0005636_abnormal_mineral_homeostasis0.73861636
108MP0000230_abnormal_systemic_arterial0.73628568
109MP0003631_nervous_system_phenotype0.71923992
110MP0002882_abnormal_neuron_morphology0.71162445
111MP0009642_abnormal_blood_homeostasis0.70527169
112MP0002229_neurodegeneration0.70509503
113MP0004811_abnormal_neuron_physiology0.70496097
114MP0001756_abnormal_urination0.70413506
115MP0002735_abnormal_chemical_nociception0.69033224
116MP0002736_abnormal_nociception_after0.67023234
117MP0000778_abnormal_nervous_system0.66222898
118MP0005584_abnormal_enzyme/coenzyme_acti0.66115751
119MP0000477_abnormal_intestine_morphology0.64312035
120MP0003866_abnormal_defecation0.63645359
121MP0005448_abnormal_energy_balance0.63632584
122MP0002136_abnormal_kidney_physiology0.63399154
123MP0004085_abnormal_heartbeat0.63139837
124MP0002118_abnormal_lipid_homeostasis0.62236462
125MP0003567_abnormal_fetal_cardiomyocyte0.62112454
126MP0001270_distended_abdomen0.62001291
127MP0001299_abnormal_eye_distance/0.61663745
128MP0003633_abnormal_nervous_system0.61160828
129MP0003638_abnormal_response/metabolism_0.61138994
130MP0002938_white_spotting0.60103975
131MP0005551_abnormal_eye_electrophysiolog0.58112532
132MP0000490_abnormal_crypts_of0.57371512
133MP0005319_abnormal_enzyme/_coenzyme0.55739159
134MP0003938_abnormal_ear_development0.54738188

Predicted human phenotypes

RankGene SetZ-score
1* Limb dystonia (HP:0002451)8.42098512
2Abnormality of glutamine family amino acid metabolism (HP:0010902)7.40755506
3Pheochromocytoma (HP:0002666)5.59864040
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.24921066
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.12866574
6Abnormality of proline metabolism (HP:0010907)5.05794404
7Hydroxyprolinuria (HP:0003080)5.05794404
8Neuroendocrine neoplasm (HP:0100634)5.01898842
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.50167178
10* Hypothermia (HP:0002045)4.39244588
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.29609564
12Fat malabsorption (HP:0002630)4.24069417
13Hyperinsulinemic hypoglycemia (HP:0000825)4.19092590
14Visual hallucinations (HP:0002367)4.05439105
15Hyperglycinuria (HP:0003108)4.02912147
16Failure to thrive in infancy (HP:0001531)3.86185716
17Hypoglycemic seizures (HP:0002173)3.74678659
18Proximal tubulopathy (HP:0000114)3.73576744
19Potter facies (HP:0002009)3.72193218
20Facial shape deformation (HP:0011334)3.72193218
21Malnutrition (HP:0004395)3.69356744
22Abnormality of serine family amino acid metabolism (HP:0010894)3.69327553
23Abnormality of glycine metabolism (HP:0010895)3.69327553
24Widely patent fontanelles and sutures (HP:0004492)3.69312615
25Acanthocytosis (HP:0001927)3.57761390
26Deep venous thrombosis (HP:0002625)3.54794300
27Orthostatic hypotension (HP:0001278)3.49229660
28Hypokinesia (HP:0002375)3.48514094
29Symptomatic seizures (HP:0011145)3.47719296
30Hypoglycemic coma (HP:0001325)3.46375385
31Hyperactive renin-angiotensin system (HP:0000841)3.45456883
32Agitation (HP:0000713)3.44478501
33Metabolic alkalosis (HP:0200114)3.41107395
34Abnormality of the vitamin B12 metabolism (HP:0004341)3.33847040
35Alkalosis (HP:0001948)3.32998702
36Decreased circulating renin level (HP:0003351)3.30987434
37Abnormality of vitamin B metabolism (HP:0004340)3.29384036
38Complement deficiency (HP:0004431)3.28132553
39Hypolipoproteinemia (HP:0010981)3.24394932
40Abnormality of vitamin metabolism (HP:0100508)3.22828142
41Ketoacidosis (HP:0001993)3.18688113
42Cerebral hemorrhage (HP:0001342)3.17992455
43Postural tremor (HP:0002174)3.09067320
44Acute necrotizing encephalopathy (HP:0006965)3.08475480
45Systemic lupus erythematosus (HP:0002725)3.06534937
46Glomerulonephritis (HP:0000099)3.02465821
47Abnormal autonomic nervous system physiology (HP:0012332)2.99157379
48Abnormality of renin-angiotensin system (HP:0000847)2.95671303
49Confusion (HP:0001289)2.95659729
50Cerebral inclusion bodies (HP:0100314)2.94518301
51Abnormal mitochondria in muscle tissue (HP:0008316)2.93264499
52Abnormality of the parathyroid morphology (HP:0011766)2.88456250
53Hyperammonemia (HP:0001987)2.85845351
54Hypercortisolism (HP:0001578)2.83672844
55Acute encephalopathy (HP:0006846)2.81919820
56Morphological abnormality of the pyramidal tract (HP:0002062)2.77998081
57Hyperparathyroidism (HP:0000843)2.76114077
58Delayed gross motor development (HP:0002194)2.72253859
59Hypoventilation (HP:0002791)2.70158462
60Steatorrhea (HP:0002570)2.70095364
61Progressive macrocephaly (HP:0004481)2.64989604
62Diminished movement (HP:0002374)2.64310225
63* Muscular hypotonia of the trunk (HP:0008936)2.63413530
64Mitochondrial inheritance (HP:0001427)2.62522067
65Anxiety (HP:0000739)2.56681172
66Hyperventilation (HP:0002883)2.55086239
67Nausea (HP:0002018)2.54359164
68Myokymia (HP:0002411)2.53591683
69Focal segmental glomerulosclerosis (HP:0000097)2.49219195
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.48173010
71Epidermoid cyst (HP:0200040)2.47313944
72Late onset (HP:0003584)2.46657616
73Nephrolithiasis (HP:0000787)2.46532116
74Ketosis (HP:0001946)2.46214075
75Enlarged epiphyses (HP:0010580)2.44864784
76Rigidity (HP:0002063)2.42674778
77Conjugated hyperbilirubinemia (HP:0002908)2.41585939
78Ileus (HP:0002595)2.40115226
79Hyperphosphaturia (HP:0003109)2.39919359
80Congenital sensorineural hearing impairment (HP:0008527)2.39903922
81Abnormality of complement system (HP:0005339)2.37631574
82Hyperglycinemia (HP:0002154)2.37158821
83Poor suck (HP:0002033)2.36562133
84Intrahepatic cholestasis (HP:0001406)2.32957226
85Cerebral edema (HP:0002181)2.32449887
86Metabolic acidosis (HP:0001942)2.31808704
87Wide cranial sutures (HP:0010537)2.31100072
88Neoplasm of the peripheral nervous system (HP:0100007)2.29846773
89Osteomalacia (HP:0002749)2.28302833
90Neonatal hypoglycemia (HP:0001998)2.27407009
91Renal tubular dysfunction (HP:0000124)2.27311814
92Abnormality of purine metabolism (HP:0004352)2.27160284
93Increased purine levels (HP:0004368)2.25474064
94Hyperuricemia (HP:0002149)2.25474064
95Abnormality of nucleobase metabolism (HP:0010932)2.25209940
96Increased hepatocellular lipid droplets (HP:0006565)2.23921335
97Hypophosphatemia (HP:0002148)2.22610233
98Lipid accumulation in hepatocytes (HP:0006561)2.21997796
99Hyperglycemia (HP:0003074)2.21008207
100Abnormality of pyrimidine metabolism (HP:0004353)2.20954644
101Dysautonomia (HP:0002459)2.20000914
102Spontaneous abortion (HP:0005268)2.19561959
103Abnormality of the pancreatic islet cells (HP:0006476)2.19514405
104Abnormality of endocrine pancreas physiology (HP:0012093)2.19514405
105Thin bony cortex (HP:0002753)2.18593317
106Abnormality of magnesium homeostasis (HP:0004921)2.17839424
107Hepatic necrosis (HP:0002605)2.16096921
108Vascular calcification (HP:0004934)2.14785116
109Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13947723
110Pigmentary retinal degeneration (HP:0001146)2.13621755
111Lethargy (HP:0001254)2.13415207
112Neonatal onset (HP:0003623)2.11839677
113Delayed CNS myelination (HP:0002188)2.11819923
114Delayed epiphyseal ossification (HP:0002663)2.10591692
115Glycosuria (HP:0003076)2.09797209
116Abnormality of urine glucose concentration (HP:0011016)2.09797209
117EEG with generalized epileptiform discharges (HP:0011198)2.09645894
118Increased CSF lactate (HP:0002490)2.08885633
119Rickets (HP:0002748)2.08199744
120Progressive cerebellar ataxia (HP:0002073)2.07953281
121Chronic diarrhea (HP:0002028)2.06596419
122Abnormality of the intrinsic pathway (HP:0010989)2.05915801
123Hemorrhage of the eye (HP:0011885)2.04414577
124Dyskinesia (HP:0100660)2.03443375
125Bradykinesia (HP:0002067)2.03150767
126Restlessness (HP:0000711)2.02796919
127Hypsarrhythmia (HP:0002521)2.02541220
128* Hypotension (HP:0002615)2.02313996
129Increased intramyocellular lipid droplets (HP:0012240)2.02151084
130Focal seizures (HP:0007359)2.01157391
131Megaloblastic anemia (HP:0001889)2.00660233
132Prolonged partial thromboplastin time (HP:0003645)2.00627113
133Gout (HP:0001997)2.00308482
134Hepatocellular necrosis (HP:0001404)2.00016031
135Epileptiform EEG discharges (HP:0011182)1.99880640
136Neurofibrillary tangles (HP:0002185)1.98747059
137Abnormal urine phosphate concentration (HP:0012599)1.97134773
138Hyperaldosteronism (HP:0000859)1.97010608
139Skin nodule (HP:0200036)1.95693576
140Generalized tonic-clonic seizures (HP:0002069)1.94738439
141Renal Fanconi syndrome (HP:0001994)1.94568565
142Delusions (HP:0000746)1.93405278
143Cerebral palsy (HP:0100021)1.93053778
144Craniofacial dystonia (HP:0012179)1.91987240
145Hyperlipoproteinemia (HP:0010980)1.91719072
146Polyphagia (HP:0002591)1.91451160
147Torticollis (HP:0000473)1.88890752
148Xanthomatosis (HP:0000991)1.88237262
149Generalized aminoaciduria (HP:0002909)1.87871513
150Hypokalemia (HP:0002900)1.87701015
151Amblyopia (HP:0000646)1.85440305
152Glomerulosclerosis (HP:0000096)1.85167102
153Nephritis (HP:0000123)1.84765395
154Goiter (HP:0000853)1.84142598
155Joint hemorrhage (HP:0005261)1.84113167
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83350246
157Supranuclear gaze palsy (HP:0000605)1.82565289
158Thyroid carcinoma (HP:0002890)1.82558057
159Pancreatic islet-cell hyperplasia (HP:0004510)1.81984819
160Abnormality of chloride homeostasis (HP:0011422)1.81362293
161Hypobetalipoproteinemia (HP:0003563)1.81286600
162Genital tract atresia (HP:0001827)1.81140446
163Insulin-resistant diabetes mellitus (HP:0000831)1.80034706
164* Irritability (HP:0000737)1.79576588
165Oligomenorrhea (HP:0000876)1.78525479
166Adrenal overactivity (HP:0002717)1.77840063
167Abnormality of fatty-acid metabolism (HP:0004359)1.77401775
168Increased muscle lipid content (HP:0009058)1.77119921
169Vaginal atresia (HP:0000148)1.77082526
170Dicarboxylic aciduria (HP:0003215)1.76976791
171Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76976791
172Concave nail (HP:0001598)1.76799983
173Abnormality of serum amino acid levels (HP:0003112)1.75936419
174Depression (HP:0000716)1.75851553
175Menstrual irregularities (HP:0000858)1.75203099
176Abnormality of the common coagulation pathway (HP:0010990)1.75074326
177Focal dystonia (HP:0004373)1.74656858
178* Myoclonus (HP:0001336)1.73140549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.70558813
2MAPKAPK54.46693716
3INSRR3.93481927
4PNCK3.50811349
5CSNK1G33.46426714
6NTRK13.25150251
7GRK53.24292577
8CSNK1G23.01419046
9MAP3K122.70443358
10WNK42.63714341
11CSNK1G12.60760256
12MAP3K42.45644485
13NTRK32.38997505
14UHMK12.16061468
15ERN11.96597012
16PASK1.95064707
17MST1R1.92054264
18MAP2K41.91458640
19GRK61.83327842
20MAPK151.82396096
21WNK31.78638171
22TLK11.77993573
23STK391.74729633
24MAP2K71.73408608
25PRKD31.73205109
26EPHB21.72230085
27GRK11.72209107
28MINK11.65768857
29CAMK2A1.64142599
30DAPK21.57440979
31MAP3K91.56892507
32ARAF1.56489575
33RET1.48437317
34DYRK21.47965086
35PRKG21.47645974
36GRK71.37191939
37PAK31.34358550
38FGR1.33789342
39ADRBK21.31581678
40PIK3CA1.31420334
41MARK11.30603802
42NME11.28227916
43CAMK2B1.25772304
44MAP3K21.24239161
45PTK21.22264420
46CAMK2D1.22140614
47DYRK1B1.20318388
48EPHA21.16664902
49ADRBK11.15937245
50MAP3K101.14567626
51PLK21.11320430
52HIPK21.10434362
53ERBB21.10067834
54TAOK31.03940253
55NTRK20.99300032
56CAMK2G0.98670493
57PINK10.97939904
58CDK50.96750949
59CASK0.95841704
60ERBB40.94888793
61SGK20.93583580
62PTK60.85242992
63CDK140.84920696
64MAPK130.83629972
65RIPK10.83118187
66PRKCG0.82512788
67OXSR10.82259940
68MAP3K110.81820911
69PDK20.80878850
70TNIK0.80136178
71CDK150.79884355
72WNK10.79094236
73CDK180.78316678
74BCR0.77747118
75MAP3K10.77213144
76FRK0.76722664
77BCKDK0.74381604
78DDR20.71621265
79CDK11A0.69629084
80FGFR30.68029241
81IRAK20.66442956
82KSR20.66432576
83EPHA40.65295862
84MAP2K60.64974897
85PTK2B0.64265622
86DYRK1A0.62282067
87LMTK20.62155061
88PRKCE0.61301965
89PRKAA20.61224570
90CAMKK20.59995800
91MAP2K20.59510122
92PRKACA0.55470981
93MAP2K10.53071695
94BMPR1B0.52994151
95CSNK1A10.51186647
96PRKCH0.49194009
97TESK10.49068578
98ERBB30.48823577
99RPS6KA50.47844244
100SIK10.46304539
101CAMK40.45068037
102SGK4940.43217771
103SGK2230.43217771
104DYRK30.43126834
105PRKACG0.42178562
106TYRO30.41596200
107AKT30.41428210
108CSNK1E0.41246725
109PDGFRA0.40719192
110CDC42BPA0.40215701
111CAMK1G0.40138878
112STK160.39970040
113PRKCZ0.39589774
114BRAF0.38852662
115PDPK10.38598779
116EPHB10.38404887
117PRKCA0.36838301
118RPS6KA20.36588846
119SGK30.35908097
120PRKG10.35852947
121MET0.35662975
122CSNK1A1L0.34626637
123SCYL20.34302150
124SGK10.34297110
125TAOK10.34160462
126PHKG10.34108956
127PHKG20.34108956
128IGF1R0.32306405
129FER0.31449876
130CHUK0.31096786
131TESK20.30803453
132MATK0.30281764
133PAK60.29519709
134FGFR40.29515609
135PRKCB0.28910941
136PKN10.28098661
137IRAK10.27628005
138LATS20.27525112
139GSK3A0.27522410
140TSSK60.26406822
141PRKAA10.25634998
142SIK20.25329122

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.10269399
2* Cocaine addiction_Homo sapiens_hsa050303.53053245
3Vitamin digestion and absorption_Homo sapiens_hsa049773.12827825
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.99892248
5Synaptic vesicle cycle_Homo sapiens_hsa047212.87700982
6Parkinsons disease_Homo sapiens_hsa050122.82944820
7Caffeine metabolism_Homo sapiens_hsa002322.74823111
8Oxidative phosphorylation_Homo sapiens_hsa001902.72148085
9Sulfur metabolism_Homo sapiens_hsa009202.45313397
10Renin-angiotensin system_Homo sapiens_hsa046142.43245331
11* Tyrosine metabolism_Homo sapiens_hsa003502.39753787
12* Amphetamine addiction_Homo sapiens_hsa050312.36373784
13Chemical carcinogenesis_Homo sapiens_hsa052042.34955789
14Protein export_Homo sapiens_hsa030602.33898853
15Collecting duct acid secretion_Homo sapiens_hsa049662.26280488
16Vibrio cholerae infection_Homo sapiens_hsa051102.11110476
17Insulin secretion_Homo sapiens_hsa049112.03120367
18* Tryptophan metabolism_Homo sapiens_hsa003802.02328624
19* Serotonergic synapse_Homo sapiens_hsa047262.01025429
20Linoleic acid metabolism_Homo sapiens_hsa005911.97458786
21* Dopaminergic synapse_Homo sapiens_hsa047281.96300850
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.92861740
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80129007
24Butanoate metabolism_Homo sapiens_hsa006501.79509484
25Mineral absorption_Homo sapiens_hsa049781.79410589
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78586583
27Alzheimers disease_Homo sapiens_hsa050101.72798115
28Fatty acid elongation_Homo sapiens_hsa000621.61216960
29* Phenylalanine metabolism_Homo sapiens_hsa003601.59329018
30PPAR signaling pathway_Homo sapiens_hsa033201.58232496
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55312079
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54747119
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42674663
34* Histidine metabolism_Homo sapiens_hsa003401.41696771
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39185773
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34103598
37Cholinergic synapse_Homo sapiens_hsa047251.33204616
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32858887
39Folate biosynthesis_Homo sapiens_hsa007901.30045534
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29523380
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.25528058
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23613691
43Fructose and mannose metabolism_Homo sapiens_hsa000511.22986302
44Protein digestion and absorption_Homo sapiens_hsa049741.16910385
45Steroid biosynthesis_Homo sapiens_hsa001001.16195239
46GABAergic synapse_Homo sapiens_hsa047271.16085872
47Huntingtons disease_Homo sapiens_hsa050161.14764784
48Nicotine addiction_Homo sapiens_hsa050331.05412353
49Pyruvate metabolism_Homo sapiens_hsa006201.03660721
50Taste transduction_Homo sapiens_hsa047421.02971774
51Arachidonic acid metabolism_Homo sapiens_hsa005901.00120416
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99948372
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99530049
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98647392
55Type II diabetes mellitus_Homo sapiens_hsa049300.97843298
56Propanoate metabolism_Homo sapiens_hsa006400.97214178
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95165207
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92087134
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90638777
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90356953
61Ether lipid metabolism_Homo sapiens_hsa005650.88450658
62Circadian entrainment_Homo sapiens_hsa047130.86567142
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84002196
64Bile secretion_Homo sapiens_hsa049760.83423739
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83374579
66* Alcoholism_Homo sapiens_hsa050340.82135210
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79839192
68Long-term depression_Homo sapiens_hsa047300.79339230
69Renin secretion_Homo sapiens_hsa049240.79004287
70Gap junction_Homo sapiens_hsa045400.77596175
71Cardiac muscle contraction_Homo sapiens_hsa042600.77401500
72Peroxisome_Homo sapiens_hsa041460.75050171
73Thyroid hormone synthesis_Homo sapiens_hsa049180.74659842
74Fatty acid metabolism_Homo sapiens_hsa012120.74409948
75Long-term potentiation_Homo sapiens_hsa047200.74398855
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72396518
77Fatty acid degradation_Homo sapiens_hsa000710.72301712
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70293607
79Arginine biosynthesis_Homo sapiens_hsa002200.67445379
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67133495
81Glucagon signaling pathway_Homo sapiens_hsa049220.66947918
82Starch and sucrose metabolism_Homo sapiens_hsa005000.65805346
83Prion diseases_Homo sapiens_hsa050200.65606294
84Glutamatergic synapse_Homo sapiens_hsa047240.65519445
85Pancreatic secretion_Homo sapiens_hsa049720.65449730
86Nitrogen metabolism_Homo sapiens_hsa009100.65174049
87Fat digestion and absorption_Homo sapiens_hsa049750.63410552
88Morphine addiction_Homo sapiens_hsa050320.61852350
89Arginine and proline metabolism_Homo sapiens_hsa003300.61113580
90Fatty acid biosynthesis_Homo sapiens_hsa000610.59732582
91Type I diabetes mellitus_Homo sapiens_hsa049400.59377694
92Retinol metabolism_Homo sapiens_hsa008300.58933444
93Regulation of autophagy_Homo sapiens_hsa041400.55998240
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54994666
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54978701
96Estrogen signaling pathway_Homo sapiens_hsa049150.52844437
97ABC transporters_Homo sapiens_hsa020100.51125519
98Salivary secretion_Homo sapiens_hsa049700.50639099
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50224057
100Sulfur relay system_Homo sapiens_hsa041220.49153467
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49131380
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48647895
103* Metabolic pathways_Homo sapiens_hsa011000.46510465
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45373310
105Selenocompound metabolism_Homo sapiens_hsa004500.44506969
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.43777702
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43690721
108Phagosome_Homo sapiens_hsa041450.40271388
109GnRH signaling pathway_Homo sapiens_hsa049120.40087189
110Sphingolipid metabolism_Homo sapiens_hsa006000.40034890
111Rheumatoid arthritis_Homo sapiens_hsa053230.39727636
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.38983737
113Complement and coagulation cascades_Homo sapiens_hsa046100.38847045
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37766162
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37573026
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37377911
117Glycerolipid metabolism_Homo sapiens_hsa005610.37128355
118Gastric acid secretion_Homo sapiens_hsa049710.35117529
119Biosynthesis of amino acids_Homo sapiens_hsa012300.34447035
120beta-Alanine metabolism_Homo sapiens_hsa004100.33956097
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.33931011
122Glutathione metabolism_Homo sapiens_hsa004800.33920602
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33562967
124Galactose metabolism_Homo sapiens_hsa000520.32415928
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29675565
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29427970
127Carbon metabolism_Homo sapiens_hsa012000.29323330
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20494217

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