DDHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cellular amide metabolic process (GO:0034250)5.05674841
2monoubiquitinated protein deubiquitination (GO:0035520)4.79030193
3positive regulation of developmental pigmentation (GO:0048087)4.74503721
4interkinetic nuclear migration (GO:0022027)4.49585982
5protein K11-linked deubiquitination (GO:0035871)4.42008960
6regulation of pigment cell differentiation (GO:0050932)4.36121164
7regulation of B cell receptor signaling pathway (GO:0050855)4.32982314
8protein K48-linked deubiquitination (GO:0071108)4.14912833
9neural tube formation (GO:0001841)4.14298002
10establishment of protein localization to Golgi (GO:0072600)3.97147301
11indolalkylamine metabolic process (GO:0006586)3.93400543
12lipid translocation (GO:0034204)3.93006490
13phospholipid translocation (GO:0045332)3.93006490
14cellular response to ethanol (GO:0071361)3.86818931
15phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.81174699
16indole-containing compound catabolic process (GO:0042436)3.78380895
17indolalkylamine catabolic process (GO:0046218)3.78380895
18tryptophan catabolic process (GO:0006569)3.78380895
19positive regulation by symbiont of host defense response (GO:0052509)3.73441465
20modulation by symbiont of host defense response (GO:0052031)3.73441465
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73441465
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73441465
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.73441465
24modulation by symbiont of host immune response (GO:0052553)3.73441465
25histone H3-K4 trimethylation (GO:0080182)3.70488962
26L-amino acid import (GO:0043092)3.64410698
27positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.61181119
28regulation of establishment of cell polarity (GO:2000114)3.59615721
29negative regulation of neurotransmitter secretion (GO:0046929)3.54613252
30tryptophan metabolic process (GO:0006568)3.54583653
31multicellular organism reproduction (GO:0032504)3.53898560
32amino acid import (GO:0043090)3.48369808
33negative regulation of neurotransmitter transport (GO:0051589)3.47220495
34kynurenine metabolic process (GO:0070189)3.29538888
35negative regulation of mast cell activation (GO:0033004)3.29232137
36snRNA transcription (GO:0009301)3.28204915
37cilium or flagellum-dependent cell motility (GO:0001539)3.27193069
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.25735754
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.24779640
40regulation of translation, ncRNA-mediated (GO:0045974)3.24779640
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24779640
42fusion of sperm to egg plasma membrane (GO:0007342)3.21772101
43histone H3-K9 methylation (GO:0051567)3.19864126
44acrosome reaction (GO:0007340)3.19805621
45microglial cell activation (GO:0001774)3.17725654
46T-helper 1 type immune response (GO:0042088)3.16416214
47protein K63-linked deubiquitination (GO:0070536)3.15884864
48piRNA metabolic process (GO:0034587)3.13940942
49acrosome assembly (GO:0001675)3.11434581
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10178596
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09221576
52peptidyl-lysine trimethylation (GO:0018023)3.07936786
53regulation of activation of Janus kinase activity (GO:0010533)3.06252936
54microtubule anchoring (GO:0034453)3.04286690
55signal peptide processing (GO:0006465)3.03906562
56regulation of establishment or maintenance of cell polarity (GO:0032878)3.03816904
57histone H3-K9 modification (GO:0061647)3.02916123
58macrophage activation involved in immune response (GO:0002281)3.02840063
59regulation of sarcomere organization (GO:0060297)2.99859456
60cellular potassium ion homeostasis (GO:0030007)2.99833817
61alanine transport (GO:0032328)2.98795560
62sperm motility (GO:0030317)2.97507514
63fucose catabolic process (GO:0019317)2.96915390
64L-fucose metabolic process (GO:0042354)2.96915390
65L-fucose catabolic process (GO:0042355)2.96915390
66protein targeting to Golgi (GO:0000042)2.96078486
67negative regulation of calcium ion transport into cytosol (GO:0010523)2.92930087
68reproduction (GO:0000003)2.92803764
69neutrophil activation involved in immune response (GO:0002283)2.92567916
70motile cilium assembly (GO:0044458)2.92365856
71peptidyl-lysine methylation (GO:0018022)2.89237322
72B cell receptor signaling pathway (GO:0050853)2.87484699
73indole-containing compound metabolic process (GO:0042430)2.82683372
74central nervous system neuron axonogenesis (GO:0021955)2.81624703
75retrograde transport, vesicle recycling within Golgi (GO:0000301)2.80927858
76positive regulation of mast cell degranulation (GO:0043306)2.79803637
77positive regulation of mast cell activation involved in immune response (GO:0033008)2.79803637
78gamma-aminobutyric acid transport (GO:0015812)2.77659965
79detection of light stimulus involved in visual perception (GO:0050908)2.77493767
80detection of light stimulus involved in sensory perception (GO:0050962)2.77493767
81cell wall macromolecule catabolic process (GO:0016998)2.76677380
82cell wall macromolecule metabolic process (GO:0044036)2.76677380
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75811865
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74674307
85regulation of hippo signaling (GO:0035330)2.74074072
86positive regulation of heat generation (GO:0031652)2.73268384
87positive regulation of granulocyte differentiation (GO:0030854)2.73148676
88regulation of MHC class I biosynthetic process (GO:0045343)2.72580678
89reciprocal meiotic recombination (GO:0007131)2.72415448
90reciprocal DNA recombination (GO:0035825)2.72415448
91negative T cell selection (GO:0043383)2.69928054
92histone lysine methylation (GO:0034968)2.68073917
93axonemal dynein complex assembly (GO:0070286)2.67650053
94ionotropic glutamate receptor signaling pathway (GO:0035235)2.67570377
95gene silencing by RNA (GO:0031047)2.67537672
96regulation of beta-amyloid formation (GO:1902003)2.67495389
97photoreceptor cell maintenance (GO:0045494)2.67437755
98positive regulation of monocyte chemotaxis (GO:0090026)2.67006019
99nucleus localization (GO:0051647)2.64532711
100positive regulation of interleukin-17 production (GO:0032740)2.64251645
101locomotory exploration behavior (GO:0035641)2.59401268
102DNA methylation involved in gamete generation (GO:0043046)2.59321779
103positive regulation of chemokine biosynthetic process (GO:0045080)2.59320915
104prenylation (GO:0097354)2.59221190
105protein prenylation (GO:0018342)2.59221190
106negative thymic T cell selection (GO:0045060)2.58211386
107sodium ion export (GO:0071436)2.58112458
108regulation of cellular amide metabolic process (GO:0034248)2.58102898
109natural killer cell mediated cytotoxicity (GO:0042267)2.58087505
110natural killer cell mediated immunity (GO:0002228)2.58087505
111cAMP catabolic process (GO:0006198)2.57949007
112pericardium development (GO:0060039)2.57653572
113double-strand break repair via homologous recombination (GO:0000724)2.56514755
114regulation of membrane lipid distribution (GO:0097035)2.56407333
115eosinophil chemotaxis (GO:0048245)2.55203034
116regulation of gene silencing by RNA (GO:0060966)2.54617397
117regulation of posttranscriptional gene silencing (GO:0060147)2.54617397
118regulation of gene silencing by miRNA (GO:0060964)2.54617397
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.54128760
120ventricular system development (GO:0021591)2.53580856
121cellular response to sterol (GO:0036315)2.53457320
122positive T cell selection (GO:0043368)2.53074952
123cerebellar Purkinje cell differentiation (GO:0021702)2.51731118
124central nervous system projection neuron axonogenesis (GO:0021952)2.51547112
125NAD biosynthetic process (GO:0009435)2.51033802
126epithelial cilium movement (GO:0003351)2.50992659
127recombinational repair (GO:0000725)2.50919950
128regulation of memory T cell differentiation (GO:0043380)2.49924694
129negative regulation of interleukin-17 production (GO:0032700)2.49757998
130ovulation cycle (GO:0042698)2.48459228
131reflex (GO:0060004)2.48139418
132male meiosis (GO:0007140)2.47863595
133sister chromatid cohesion (GO:0007062)2.47407709
134histone mRNA catabolic process (GO:0071044)2.47094995
135negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.47008792
136granulocyte activation (GO:0036230)2.46300067
137replicative senescence (GO:0090399)2.46110155
138central nervous system myelination (GO:0022010)2.45843680
139axon ensheathment in central nervous system (GO:0032291)2.45843680
140serotonin metabolic process (GO:0042428)2.44761856
141plasma membrane fusion (GO:0045026)2.44661028
142detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44316960
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43786504
144regulation of interleukin-17 production (GO:0032660)2.43540683
145positive regulation of type 2 immune response (GO:0002830)2.42352540
146cyclic nucleotide catabolic process (GO:0009214)2.41886183
147response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40905407
148response to host immune response (GO:0052572)2.40905407
149positive regulation of interleukin-12 production (GO:0032735)2.40694209
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40001194
151neutrophil activation (GO:0042119)2.39947892
152establishment of protein localization to vacuole (GO:0072666)2.38893603
153protein targeting to vacuole (GO:0006623)2.38893603
154protein targeting to lysosome (GO:0006622)2.38893603
155DNA demethylation (GO:0080111)2.38751782
156glutamate receptor signaling pathway (GO:0007215)2.38554995
157regulation of DNA endoreduplication (GO:0032875)2.37280487
158regulation of heat generation (GO:0031650)2.36168045
159C4-dicarboxylate transport (GO:0015740)2.35057004
160regulation of interferon-beta biosynthetic process (GO:0045357)2.35041300
161negative regulation of DNA-dependent DNA replication (GO:2000104)2.34790658
162regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.34289943
163regulation of developmental pigmentation (GO:0048070)2.33685906
164retinal cone cell development (GO:0046549)2.33128815
165positive regulation of mast cell activation (GO:0033005)2.33057981
166hepatocyte apoptotic process (GO:0097284)2.32779265
167positive regulation of gamma-delta T cell activation (GO:0046645)2.32206785
168regulation of ARF protein signal transduction (GO:0032012)2.31893873
169response to auditory stimulus (GO:0010996)2.31385456
170hydrogen peroxide biosynthetic process (GO:0050665)2.31230304
171regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31136067
172response to peptidoglycan (GO:0032494)2.28014900
173regulation of inositol phosphate biosynthetic process (GO:0010919)2.27803910
174superoxide anion generation (GO:0042554)2.27686919
175regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.26863181
176regulation of protein polyubiquitination (GO:1902914)2.25748788
177cytoplasmic mRNA processing body assembly (GO:0033962)2.25350648
178regulation of chronic inflammatory response (GO:0002676)2.23114214
179cilium movement (GO:0003341)2.22935075
180regulation of fever generation (GO:0031620)2.21817218
181eosinophil migration (GO:0072677)2.21083323
182response to muramyl dipeptide (GO:0032495)2.19130091
183positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.17644720
184nerve growth factor signaling pathway (GO:0038180)2.17632297
185macrophage activation (GO:0042116)2.16387756
186positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.16147031
187retinal rod cell development (GO:0046548)2.15971162
188acidic amino acid transport (GO:0015800)2.15851387
189positive regulation of macrophage cytokine production (GO:0060907)2.15260148
190positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.14908410
191positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.13801352
192response to lipoprotein particle (GO:0055094)2.12928993
193positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.11751487
194positive regulation of alpha-beta T cell proliferation (GO:0046641)2.11454396
195regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.11435452
196regulation of dendritic cell antigen processing and presentation (GO:0002604)2.11177303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.70748779
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.52794490
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39488779
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28007284
5ZNF274_21170338_ChIP-Seq_K562_Hela2.24852548
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.23272940
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.23210960
8* GBX2_23144817_ChIP-Seq_PC3_Human2.20770078
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.15902326
10FUS_26573619_Chip-Seq_HEK293_Human1.95680971
11EWS_26573619_Chip-Seq_HEK293_Human1.94384773
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93033828
13* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76522742
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.72939899
15IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71422424
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.65035675
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63572588
18* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61368485
19AR_21572438_ChIP-Seq_LNCaP_Human1.58608008
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57657020
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56302974
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54672719
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54631552
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53975381
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53347492
26* BCAT_22108803_ChIP-Seq_LS180_Human1.52422415
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52145014
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50072663
29PRDM14_20953172_ChIP-Seq_ESCs_Human1.49963447
30CBP_20019798_ChIP-Seq_JUKART_Human1.48599010
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48599010
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47332254
33CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46805717
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45245384
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43790074
36VDR_24787735_ChIP-Seq_THP-1_Human1.42137699
37DROSHA_22980978_ChIP-Seq_HELA_Human1.41798365
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41591349
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40901287
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40598630
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39882704
42SMAD4_21799915_ChIP-Seq_A2780_Human1.37516544
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36292494
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.35260652
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35116570
46* FLI1_21867929_ChIP-Seq_TH2_Mouse1.34501401
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34501110
48REST_21632747_ChIP-Seq_MESCs_Mouse1.32578082
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32513609
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32285837
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.32259623
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.31878845
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.30563555
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30481365
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29258410
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28866511
57* P300_19829295_ChIP-Seq_ESCs_Human1.27361099
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27107444
59ER_23166858_ChIP-Seq_MCF-7_Human1.26804318
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26238002
61RUNX2_22187159_ChIP-Seq_PCA_Human1.26027017
62* TCF4_22108803_ChIP-Seq_LS180_Human1.24596778
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24330119
64TP53_16413492_ChIP-PET_HCT116_Human1.23986293
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.23760641
66* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23553197
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23045584
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22655861
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21354426
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21354426
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20534065
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18997157
73STAT3_23295773_ChIP-Seq_U87_Human1.18606285
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18057108
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17886817
76TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17870183
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17735020
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.17043618
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16198601
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.16107714
81AR_25329375_ChIP-Seq_VCAP_Human1.15943009
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15881366
83CDX2_22108803_ChIP-Seq_LS180_Human1.15494812
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13069411
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13069411
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12575573
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12322688
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11812719
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11674416
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11349918
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.11225710
92* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10729797
93* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10367713
94TCF4_23295773_ChIP-Seq_U87_Human1.09641312
95VDR_22108803_ChIP-Seq_LS180_Human1.09166637
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.09081234
97P53_22387025_ChIP-Seq_ESCs_Mouse1.08816409
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08467343
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.08334417
100P300_18555785_Chip-Seq_ESCs_Mouse1.07465299
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07317485
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06466468
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.06106436
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05996135
105IRF1_19129219_ChIP-ChIP_H3396_Human1.05950590
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.05844903
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05457687
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04804281
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04574537
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04557609
111TAF15_26573619_Chip-Seq_HEK293_Human1.03557667
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03408435
113GATA3_26560356_Chip-Seq_TH2_Human1.03339383
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03255026
115* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03049871
116NANOG_19829295_ChIP-Seq_ESCs_Human1.02568300
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.02493468
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02399764
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02287469
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.01997942
121JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01925958
122EED_16625203_ChIP-ChIP_MESCs_Mouse1.01705081
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.00867412
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.00259192
125KDM2B_26808549_Chip-Seq_REH_Human1.00045704
126RUNX_20019798_ChIP-Seq_JUKART_Human1.00023996
127AHR_22903824_ChIP-Seq_MCF-7_Human0.99455311
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.98716253
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98595547
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98042391
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98030890
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97202707
133* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96658304
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96506339
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.96341168
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96017876
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96017876
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95993992
139IGF1R_20145208_ChIP-Seq_DFB_Human0.95496306
140* RXR_22108803_ChIP-Seq_LS180_Human0.95298197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.20311838
2MP0005410_abnormal_fertilization4.00734629
3MP0003690_abnormal_glial_cell2.85396505
4MP0009046_muscle_twitch2.79152570
5MP0004859_abnormal_synaptic_plasticity2.72912362
6MP0002254_reproductive_system_inflammat2.61516152
7MP0003880_abnormal_central_pattern2.43055191
8MP0005551_abnormal_eye_electrophysiolog2.42259332
9MP0003787_abnormal_imprinting2.39789683
10MP0000569_abnormal_digit_pigmentation2.27753144
11MP0004510_myositis2.26465563
12MP0005423_abnormal_somatic_nervous2.25079065
13MP0001835_abnormal_antigen_presentation2.20900389
14MP0004270_analgesia2.17080000
15MP0002148_abnormal_hypersensitivity_rea2.07159022
16MP0003763_abnormal_thymus_physiology2.06828902
17MP0000427_abnormal_hair_cycle2.04826545
18MP0004885_abnormal_endolymph1.99471607
19MP0002009_preneoplasia1.95367438
20MP0002419_abnormal_innate_immunity1.94139098
21MP0001486_abnormal_startle_reflex1.93577573
22MP0003303_peritoneal_inflammation1.91591367
23MP0003646_muscle_fatigue1.89992728
24MP0005310_abnormal_salivary_gland1.88915451
25MP0003183_abnormal_peptide_metabolism1.87091859
26MP0003635_abnormal_synaptic_transmissio1.85542235
27MP0006082_CNS_inflammation1.84226015
28MP0003011_delayed_dark_adaptation1.82974263
29MP0008961_abnormal_basal_metabolism1.81432676
30MP0000920_abnormal_myelination1.80980080
31MP0003436_decreased_susceptibility_to1.80902056
32MP0003195_calcinosis1.78983566
33MP0002064_seizures1.76578373
34MP0000604_amyloidosis1.76262239
35MP0009785_altered_susceptibility_to1.75675518
36MP0001502_abnormal_circadian_rhythm1.73326664
37MP0003075_altered_response_to1.72694930
38MP0003136_yellow_coat_color1.72219905
39MP0005174_abnormal_tail_pigmentation1.71532494
40MP0000383_abnormal_hair_follicle1.69128005
41MP0002396_abnormal_hematopoietic_system1.68865493
42MP0005000_abnormal_immune_tolerance1.65742697
43MP0004858_abnormal_nervous_system1.63512365
44MP0005253_abnormal_eye_physiology1.63251573
45MP0001440_abnormal_grooming_behavior1.60609339
46MP0005646_abnormal_pituitary_gland1.58467891
47MP0009745_abnormal_behavioral_response1.56789233
48MP0001984_abnormal_olfaction1.56125266
49MP0005387_immune_system_phenotype1.55105277
50MP0001790_abnormal_immune_system1.55105277
51MP0005167_abnormal_blood-brain_barrier1.53689089
52MP0002102_abnormal_ear_morphology1.51448102
53MP0003890_abnormal_embryonic-extraembry1.51061290
54MP0002063_abnormal_learning/memory/cond1.50584836
55MP0000685_abnormal_immune_system1.49853360
56MP0009764_decreased_sensitivity_to1.48473556
57MP0003329_amyloid_beta_deposits1.48349543
58MP0002735_abnormal_chemical_nociception1.47833448
59MP0002572_abnormal_emotion/affect_behav1.46030861
60MP0003634_abnormal_glial_cell1.45995288
61MP0005171_absent_coat_pigmentation1.42943456
62MP0001501_abnormal_sleep_pattern1.42225560
63MP0003698_abnormal_male_reproductive1.41449385
64MP0004043_abnormal_pH_regulation1.41396335
65MP0001853_heart_inflammation1.40326989
66MP0010094_abnormal_chromosome_stability1.39307010
67MP0002090_abnormal_vision1.39143093
68MP0000372_irregular_coat_pigmentation1.38891148
69MP0002638_abnormal_pupillary_reflex1.37242231
70MP0005025_abnormal_response_to1.34203231
71MP0005075_abnormal_melanosome_morpholog1.32257843
72MP0004742_abnormal_vestibular_system1.31201387
73MP0006054_spinal_hemorrhage1.29017884
74MP0002452_abnormal_antigen_presenting1.28492608
75MP0002229_neurodegeneration1.27027703
76MP0001968_abnormal_touch/_nociception1.26727095
77MP0003633_abnormal_nervous_system1.26355101
78MP0005645_abnormal_hypothalamus_physiol1.26024663
79MP0003950_abnormal_plasma_membrane1.25728528
80MP0002272_abnormal_nervous_system1.21691143
81MP0008058_abnormal_DNA_repair1.21492624
82MP0002734_abnormal_mechanical_nocicepti1.21188287
83MP0000015_abnormal_ear_pigmentation1.19650158
84MP0002168_other_aberrant_phenotype1.19420010
85MP0009780_abnormal_chondrocyte_physiolo1.18418584
86MP0002723_abnormal_immune_serum1.17092135
87MP0003172_abnormal_lysosome_physiology1.16290339
88MP0000371_diluted_coat_color1.15072690
89MP0008872_abnormal_physiological_respon1.12509387
90MP0002998_abnormal_bone_remodeling1.09160211
91MP0001986_abnormal_taste_sensitivity1.07647148
92MP0000778_abnormal_nervous_system1.07488947
93MP0005671_abnormal_response_to1.06681304
94MP0003631_nervous_system_phenotype1.05005026
95MP0002067_abnormal_sensory_capabilities1.04144300
96MP0005166_decreased_susceptibility_to1.01245441
97MP0002138_abnormal_hepatobiliary_system1.00625542
98MP0002166_altered_tumor_susceptibility1.00082503
99MP0003045_fibrosis0.99607988
100MP0005266_abnormal_metabolism0.98561153
101MP0010386_abnormal_urinary_bladder0.98409200
102MP0001929_abnormal_gametogenesis0.98351590
103MP0005195_abnormal_posterior_eye0.98325894
104MP0008877_abnormal_DNA_methylation0.97368572
105MP0001819_abnormal_immune_cell0.97084957
106MP0001800_abnormal_humoral_immune0.97030732
107MP0009840_abnormal_foam_cell0.96516265
108MP0002882_abnormal_neuron_morphology0.94887702
109MP0003448_altered_tumor_morphology0.94175559
110MP0010678_abnormal_skin_adnexa0.93546364
111MP0002095_abnormal_skin_pigmentation0.93455064
112MP0000703_abnormal_thymus_morphology0.93395202
113MP0000566_synostosis0.93365965
114MP0008569_lethality_at_weaning0.93356562
115MP0002420_abnormal_adaptive_immunity0.93157353
116MP0004381_abnormal_hair_follicle0.92884482
117MP0002928_abnormal_bile_duct0.92336846
118MP0006292_abnormal_olfactory_placode0.92148893
119MP0001346_abnormal_lacrimal_gland0.91644495
120MP0004142_abnormal_muscle_tone0.91174517
121MP0005389_reproductive_system_phenotype0.90221029
122MP0005058_abnormal_lysosome_morphology0.90211841
123MP0004808_abnormal_hematopoietic_stem0.89473829
124MP0006072_abnormal_retinal_apoptosis0.89467115
125MP0004924_abnormal_behavior0.89253248
126MP0005386_behavior/neurological_phenoty0.89253248
127MP0002736_abnormal_nociception_after0.87021232
128MP0004130_abnormal_muscle_cell0.86020032
129MP0003252_abnormal_bile_duct0.85860207
130MP0002398_abnormal_bone_marrow0.85026324
131MP0004145_abnormal_muscle_electrophysio0.83913057
132MP0001919_abnormal_reproductive_system0.83743788
133MP0001324_abnormal_eye_pigmentation0.83010412
134MP0005647_abnormal_sex_gland0.82639302
135MP0000689_abnormal_spleen_morphology0.82587414
136MP0004215_abnormal_myocardial_fiber0.82504789
137MP0003943_abnormal_hepatobiliary_system0.81327567
138MP0001970_abnormal_pain_threshold0.80882010
139MP0003656_abnormal_erythrocyte_physiolo0.80693370
140MP0001485_abnormal_pinna_reflex0.80132857
141MP0004147_increased_porphyrin_level0.80012172
142MP0002733_abnormal_thermal_nociception0.79897992
143MP0009115_abnormal_fat_cell0.79554637
144MP0003632_abnormal_nervous_system0.78828838
145MP0005535_abnormal_body_temperature0.78299274
146MP0001873_stomach_inflammation0.78241989
147MP0000631_abnormal_neuroendocrine_gland0.78143536
148MP0000716_abnormal_immune_system0.77449837
149MP0003091_abnormal_cell_migration0.77044917
150MP0002405_respiratory_system_inflammati0.76568581
151MP0008260_abnormal_autophagy0.76016224
152MP0002163_abnormal_gland_morphology0.74192324
153MP0002653_abnormal_ependyma_morphology0.73564068
154MP0004484_altered_response_of0.73215315
155MP0002837_dystrophic_cardiac_calcinosis0.72612655

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.18536795
2Absent/shortened dynein arms (HP:0200106)5.13090081
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.13090081
4Hyperventilation (HP:0002883)4.46246925
5Abnormal respiratory motile cilium physiology (HP:0012261)4.05821387
6Eczematoid dermatitis (HP:0000976)3.86898648
7Recurrent gram-negative bacterial infections (HP:0005420)3.84550133
8Recurrent bacterial skin infections (HP:0005406)3.75226557
9Recurrent abscess formation (HP:0002722)3.74081385
10Aplasia involving bones of the extremities (HP:0009825)3.54553131
11Aplasia involving bones of the upper limbs (HP:0009823)3.54553131
12Aplasia of the phalanges of the hand (HP:0009802)3.54553131
13Neurofibrillary tangles (HP:0002185)3.48727362
14Pancreatic cysts (HP:0001737)3.40872247
15Mediastinal lymphadenopathy (HP:0100721)3.26116796
16Protruding tongue (HP:0010808)3.20407549
17Dyschromatopsia (HP:0007641)3.16812309
18Supranuclear gaze palsy (HP:0000605)3.15794448
19Rhinitis (HP:0012384)3.13084135
20Abnormality of macrophages (HP:0004311)3.12086230
21Abnormal ciliary motility (HP:0012262)3.11202238
22Slow saccadic eye movements (HP:0000514)3.05634351
23Volvulus (HP:0002580)3.05121410
24Pigmentary retinal degeneration (HP:0001146)3.00659180
25Fair hair (HP:0002286)2.99726212
26Absent speech (HP:0001344)2.93217964
27Tetraparesis (HP:0002273)2.92848891
28Abnormal respiratory motile cilium morphology (HP:0005938)2.91245576
29Abnormal respiratory epithelium morphology (HP:0012253)2.91245576
30Autoimmune thrombocytopenia (HP:0001973)2.91176042
31Widely spaced teeth (HP:0000687)2.87831971
32Hemiparesis (HP:0001269)2.83265001
33Progressive cerebellar ataxia (HP:0002073)2.75569774
34Retrobulbar optic neuritis (HP:0100654)2.73684983
35Optic neuritis (HP:0100653)2.73684983
36Stomach cancer (HP:0012126)2.68715426
37Abnormality of the renal cortex (HP:0011035)2.65431887
38Clumsiness (HP:0002312)2.63507825
39Congenital stationary night blindness (HP:0007642)2.62436262
40Gingivitis (HP:0000230)2.57339768
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.56271306
42Focal motor seizures (HP:0011153)2.54227236
43Progressive inability to walk (HP:0002505)2.44632435
44Autoimmune hemolytic anemia (HP:0001890)2.43220853
45Choroideremia (HP:0001139)2.41477560
46Thyroiditis (HP:0100646)2.40636602
47Abnormality of T cell number (HP:0011839)2.40593269
48Chronic bronchitis (HP:0004469)2.39290667
49Broad-based gait (HP:0002136)2.38986402
50Genetic anticipation (HP:0003743)2.36415122
51Cerebral inclusion bodies (HP:0100314)2.35450771
52Macular degeneration (HP:0000608)2.34116251
53Panhypogammaglobulinemia (HP:0003139)2.33901967
54Stomatitis (HP:0010280)2.30672648
55Generalized hypopigmentation of hair (HP:0011358)2.29083066
56Nasal polyposis (HP:0100582)2.27318403
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.24653541
58Megalencephaly (HP:0001355)2.23525058
59T lymphocytopenia (HP:0005403)2.22769961
60Clubbing of toes (HP:0100760)2.20719663
61Dialeptic seizures (HP:0011146)2.20555956
62Inability to walk (HP:0002540)2.20262958
63Diplopia (HP:0000651)2.19787622
64Abnormality of binocular vision (HP:0011514)2.19787622
65Progressive visual loss (HP:0000529)2.19273910
66Abnormality of B cell number (HP:0010975)2.17852162
67Orchitis (HP:0100796)2.16378322
68Decreased central vision (HP:0007663)2.16324400
69Retinal atrophy (HP:0001105)2.15229513
70Recurrent skin infections (HP:0001581)2.14493122
71Cystic liver disease (HP:0006706)2.10850063
72Abnormality of chromosome stability (HP:0003220)2.10383969
73Tented upper lip vermilion (HP:0010804)2.09963784
74Infertility (HP:0000789)2.09761933
75Type II lissencephaly (HP:0007260)2.09694802
76Short chin (HP:0000331)2.09313528
77Epileptic encephalopathy (HP:0200134)2.08489183
78Urinary bladder sphincter dysfunction (HP:0002839)2.08254070
79Medial flaring of the eyebrow (HP:0010747)2.07874526
80Dysmetric saccades (HP:0000641)2.06927754
81Chronic hepatic failure (HP:0100626)2.06903792
82Abnormality of macular pigmentation (HP:0008002)2.06723317
83Increased IgM level (HP:0003496)2.06201771
84Action tremor (HP:0002345)2.04582826
85Nephronophthisis (HP:0000090)2.02874824
86Cone-rod dystrophy (HP:0000548)2.00464303
87Abnormality of the nasal septum (HP:0000419)2.00237990
88Abolished electroretinogram (ERG) (HP:0000550)1.97247855
89Submucous cleft hard palate (HP:0000176)1.97183345
90Increased corneal curvature (HP:0100692)1.96664158
91Keratoconus (HP:0000563)1.96664158
92Absence seizures (HP:0002121)1.96663128
93Segmental peripheral demyelination/remyelination (HP:0003481)1.96504480
94Prostate neoplasm (HP:0100787)1.96435956
95Drooling (HP:0002307)1.93999222
96Long nose (HP:0003189)1.93502638
97Abnormality of saccadic eye movements (HP:0000570)1.93148739
98Gait imbalance (HP:0002141)1.92859286
99Intestinal atresia (HP:0011100)1.90867254
100Chromsome breakage (HP:0040012)1.90388685
101Bony spicule pigmentary retinopathy (HP:0007737)1.89797398
102Increased cerebral lipofuscin (HP:0011813)1.89675637
103Postural instability (HP:0002172)1.88881056
104Atonic seizures (HP:0010819)1.86799627
105Birth length less than 3rd percentile (HP:0003561)1.85654803
106Chronic mucocutaneous candidiasis (HP:0002728)1.85636002
107Recurrent cutaneous fungal infections (HP:0011370)1.85636002
108Cupped ear (HP:0000378)1.84526591
109Sloping forehead (HP:0000340)1.84230109
110Prominent nose (HP:0000448)1.84110563
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.83912919
112Excessive salivation (HP:0003781)1.83539243
113Scotoma (HP:0000575)1.83193196
114Male infertility (HP:0003251)1.82826550
115Basal ganglia calcification (HP:0002135)1.81817973
116Vasculitis (HP:0002633)1.80954749
117Abnormality of the renal medulla (HP:0100957)1.80637430
118Small hand (HP:0200055)1.80567323
119Congenital primary aphakia (HP:0007707)1.80419620
120Renal cortical cysts (HP:0000803)1.79846327
121Truncal obesity (HP:0001956)1.79598345
122Abnormality of the ischium (HP:0003174)1.79023063
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78894935
124Bronchiectasis (HP:0002110)1.77769867
125Recurrent fungal infections (HP:0002841)1.77417804
126IgA deficiency (HP:0002720)1.77404506
127Abnormality of T cells (HP:0002843)1.76933323
128Focal seizures (HP:0007359)1.76743064
129Hemiplegia (HP:0002301)1.76725079
130Constricted visual fields (HP:0001133)1.76586977
131Disinhibition (HP:0000734)1.75869398
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.75735956
133Abnormality of the renal collecting system (HP:0004742)1.74999003
134Highly arched eyebrow (HP:0002553)1.74817962
135Febrile seizures (HP:0002373)1.74787594
136Facial diplegia (HP:0001349)1.74469601
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.74177048
138Abnormality of the prostate (HP:0008775)1.74028655
139Dysmetria (HP:0001310)1.73858620
140IgG deficiency (HP:0004315)1.73619244
141Thick nail (HP:0001805)1.73177237
142Hypoplasia of the thymus (HP:0000778)1.73029194
143Chronic diarrhea (HP:0002028)1.72885132
144Tubular atrophy (HP:0000092)1.71913628
145Hypoplastic ischia (HP:0003175)1.71712331
146Pulmonary infiltrates (HP:0002113)1.71676137
147Photophobia (HP:0000613)1.70985478
148Hypoplastic labia majora (HP:0000059)1.70812786
149Spastic tetraparesis (HP:0001285)1.70756983
150Neoplasm of the adrenal cortex (HP:0100641)1.70593560
151Acute lymphatic leukemia (HP:0006721)1.70068081
152Central scotoma (HP:0000603)1.69977110
153Astigmatism (HP:0000483)1.69869812
154Peripheral hypomyelination (HP:0007182)1.68421662
155Recurrent sinusitis (HP:0011108)1.67503828
156True hermaphroditism (HP:0010459)1.67125960
157Congenital hepatic fibrosis (HP:0002612)1.66861233
158Papillary thyroid carcinoma (HP:0002895)1.66621238
159Agammaglobulinemia (HP:0004432)1.66434976
160Attenuation of retinal blood vessels (HP:0007843)1.65779640
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64920242
162Abnormality of the fingertips (HP:0001211)1.64257994
163Gaze-evoked nystagmus (HP:0000640)1.64193685
164Myokymia (HP:0002411)1.63928488
165Abnormality of T cell physiology (HP:0011840)1.63240894
166Cerebellar dysplasia (HP:0007033)1.62784175
167Pancreatic fibrosis (HP:0100732)1.62468359
168Absent frontal sinuses (HP:0002688)1.61523487
169Dysdiadochokinesis (HP:0002075)1.61393493
170Nephrogenic diabetes insipidus (HP:0009806)1.59634981
171Abnormality of the nasal mucosa (HP:0000433)1.59428485
172Tubulointerstitial abnormality (HP:0001969)1.59248902
173Molar tooth sign on MRI (HP:0002419)1.58278088
174Abnormality of midbrain morphology (HP:0002418)1.58278088
175Myositis (HP:0100614)1.57430695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.82314136
2RIPK44.22320257
3ACVR1B3.30265610
4MAP3K143.12101974
5BMPR1B2.82208960
6PBK2.63244416
7MAP3K132.57149847
8EPHA42.45412675
9PRKD32.31741942
10MUSK2.23190624
11TNIK2.20856392
12EIF2AK31.92760163
13NTRK21.90406688
14MKNK21.74317133
15AKT31.73740110
16NTRK31.68044155
17FGR1.66234121
18ADRBK21.62734981
19IKBKE1.61413165
20TBK11.55721254
21TEC1.52441082
22STK38L1.51481684
23PAK61.46819037
24WNK31.42750906
25NUAK11.42243535
26ZAK1.40844864
27JAK31.38578574
28JAK11.37585680
29BLK1.33951600
30ERBB41.33202480
31IKBKB1.32524735
32SIK21.31582977
33KSR21.30566441
34CAMKK21.29973356
35STK391.29873861
36STK381.29091411
37BCKDK1.29028334
38ICK1.27879319
39BMPR21.26710035
40BMX1.24832441
41PIK3CG1.23075523
42CASK1.23064300
43MAP3K91.21344083
44BRD41.20782656
45TYK21.18474498
46MAP4K21.15138626
47CAMK1G1.13056464
48KIT1.09920404
49NLK1.07813703
50MELK1.06021353
51PKN11.05157736
52PNCK1.04944471
53PTK2B1.03044102
54MARK31.00938233
55ITK1.00736860
56TGFBR10.99138975
57CHUK0.98059157
58PHKG20.97802389
59PHKG10.97802389
60EPHB10.96958196
61MAP3K40.96410614
62NTRK10.94358663
63IRAK40.94270085
64IRAK30.94078462
65PIK3CA0.92986341
66LMTK20.91022984
67TAOK30.89504102
68TYRO30.88977382
69WNK10.88225943
70TXK0.87577053
71IRAK20.86573375
72SYK0.86520893
73NEK60.86174692
74IRAK10.84998812
75MAP2K70.84038805
76PINK10.84034078
77MARK10.83781441
78PDPK10.82126584
79YES10.80566863
80MAP3K70.79880963
81TRPM70.79874855
82PDK10.79409718
83PDK20.79105721
84MAP4K10.78760399
85FES0.78298203
86BTK0.76221119
87PRKCH0.76105275
88PRKCQ0.75486041
89PRKAA20.73924924
90BCR0.73719755
91CDK50.73233204
92CDK190.73207897
93SGK30.72960954
94PDGFRB0.72865051
95MAPK130.72809075
96SGK20.72198693
97SGK10.71995970
98DMPK0.71529608
99ABL20.69718702
100TNK20.68757663
101GRK10.68609701
102SGK4940.68283397
103SGK2230.68283397
104ADRBK10.67443222
105LATS10.67179509
106CSK0.67048084
107MARK20.66031537
108FGFR30.65738616
109JAK20.64082864
110PRKCE0.63354576
111CAMK1D0.62509487
112STK30.61889599
113PRPF4B0.61548782
114PDK40.61448214
115PDK30.61448214
116PLK20.60839886
117FGFR20.60829957
118BRSK20.59060402
119TAOK10.58629890
120MKNK10.58114945
121DAPK20.57946654
122PRKCZ0.57524638
123CAMK2A0.57252230
124KSR10.57127473
125ABL10.56086591
126CAMK40.54827206
127MAP3K20.54355877
128STK110.54128653
129SIK10.53685302
130HCK0.53076229
131ERBB30.52740921
132CDK30.51539906
133ATM0.51247360
134RET0.50944806
135MAPK110.50862824
136PLK40.50571535
137NEK90.49915073
138RIPK10.49896161
139MINK10.49791976
140LCK0.48221600
141PAK30.47324792
142LYN0.46842109
143ATR0.46376433
144CAMKK10.45017874
145PIM10.44193446
146FYN0.44151775
147CDK120.43873374
148INSRR0.43685900
149OXSR10.43209656
150CAMK10.40175822
151FER0.39472046
152CSNK1D0.39070811
153CSF1R0.37388671

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.42884541
2Graft-versus-host disease_Homo sapiens_hsa053322.22267896
3Dorso-ventral axis formation_Homo sapiens_hsa043201.95737152
4Primary immunodeficiency_Homo sapiens_hsa053401.95336899
5Fatty acid biosynthesis_Homo sapiens_hsa000611.93171619
6ABC transporters_Homo sapiens_hsa020101.88950007
7Allograft rejection_Homo sapiens_hsa053301.87933048
8Nitrogen metabolism_Homo sapiens_hsa009101.82715762
9Type I diabetes mellitus_Homo sapiens_hsa049401.79131718
10Homologous recombination_Homo sapiens_hsa034401.67881669
11African trypanosomiasis_Homo sapiens_hsa051431.64677955
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62680270
13Rheumatoid arthritis_Homo sapiens_hsa053231.62641227
14Non-homologous end-joining_Homo sapiens_hsa034501.59459830
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53019603
16Leishmaniasis_Homo sapiens_hsa051401.50831684
17Fanconi anemia pathway_Homo sapiens_hsa034601.49544342
18Nicotine addiction_Homo sapiens_hsa050331.48093689
19Glutamatergic synapse_Homo sapiens_hsa047241.47417846
20Malaria_Homo sapiens_hsa051441.45036178
21Osteoclast differentiation_Homo sapiens_hsa043801.43096803
22Tuberculosis_Homo sapiens_hsa051521.42775783
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.42571014
24Lysine degradation_Homo sapiens_hsa003101.38678826
25Butanoate metabolism_Homo sapiens_hsa006501.37350916
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33409836
27Morphine addiction_Homo sapiens_hsa050321.30810096
28GABAergic synapse_Homo sapiens_hsa047271.28877932
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27309180
30Olfactory transduction_Homo sapiens_hsa047401.26864337
31Synaptic vesicle cycle_Homo sapiens_hsa047211.26414212
32TNF signaling pathway_Homo sapiens_hsa046681.26112059
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16135775
34Tryptophan metabolism_Homo sapiens_hsa003801.13442724
35Autoimmune thyroid disease_Homo sapiens_hsa053201.13442294
36Chemokine signaling pathway_Homo sapiens_hsa040621.12457535
37Linoleic acid metabolism_Homo sapiens_hsa005911.10779190
38Salivary secretion_Homo sapiens_hsa049701.09767063
39Salmonella infection_Homo sapiens_hsa051321.08322271
40Mineral absorption_Homo sapiens_hsa049781.08126461
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05556919
42Circadian entrainment_Homo sapiens_hsa047131.05270011
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04613724
44Asthma_Homo sapiens_hsa053101.04545172
45Staphylococcus aureus infection_Homo sapiens_hsa051501.03971846
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03297362
47Propanoate metabolism_Homo sapiens_hsa006401.01308519
48Ether lipid metabolism_Homo sapiens_hsa005650.99740916
49Gastric acid secretion_Homo sapiens_hsa049710.98612278
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96102365
51Influenza A_Homo sapiens_hsa051640.95258968
52Type II diabetes mellitus_Homo sapiens_hsa049300.94541244
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92986869
54Lysosome_Homo sapiens_hsa041420.91008493
55Antigen processing and presentation_Homo sapiens_hsa046120.90695420
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90530438
57Collecting duct acid secretion_Homo sapiens_hsa049660.89543560
58cAMP signaling pathway_Homo sapiens_hsa040240.89339460
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.87473458
60Basal transcription factors_Homo sapiens_hsa030220.87166825
61Phagosome_Homo sapiens_hsa041450.86118081
62B cell receptor signaling pathway_Homo sapiens_hsa046620.85960357
63Long-term potentiation_Homo sapiens_hsa047200.85475089
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85345111
65Measles_Homo sapiens_hsa051620.85310552
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85058123
67Pertussis_Homo sapiens_hsa051330.84935303
68Toxoplasmosis_Homo sapiens_hsa051450.84929887
69Legionellosis_Homo sapiens_hsa051340.81172040
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80997440
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.80645668
72Platelet activation_Homo sapiens_hsa046110.80351870
73Steroid biosynthesis_Homo sapiens_hsa001000.79255189
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79156381
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78972200
76Insulin secretion_Homo sapiens_hsa049110.78310624
77Renin secretion_Homo sapiens_hsa049240.77875145
78Glycerolipid metabolism_Homo sapiens_hsa005610.77096094
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76105665
80Cholinergic synapse_Homo sapiens_hsa047250.75898271
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75498193
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75204807
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74623253
84Cocaine addiction_Homo sapiens_hsa050300.73742992
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.73716789
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72983472
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.72853117
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.72622982
89Calcium signaling pathway_Homo sapiens_hsa040200.72148542
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71873095
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71183591
92Systemic lupus erythematosus_Homo sapiens_hsa053220.70744155
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70152286
94ErbB signaling pathway_Homo sapiens_hsa040120.70101135
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69548289
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69109005
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67794702
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.65898504
99MAPK signaling pathway_Homo sapiens_hsa040100.65831012
100Serotonergic synapse_Homo sapiens_hsa047260.65677139
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.65105323
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64223666
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63901657
104FoxO signaling pathway_Homo sapiens_hsa040680.63415892
105Viral myocarditis_Homo sapiens_hsa054160.63317740
106Choline metabolism in cancer_Homo sapiens_hsa052310.63222642
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62799426
108Herpes simplex infection_Homo sapiens_hsa051680.62541807
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62439494
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.62156223
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62134926
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61677769
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61443647
114Circadian rhythm_Homo sapiens_hsa047100.61264753
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61075811
116Selenocompound metabolism_Homo sapiens_hsa004500.60569173
117Sphingolipid metabolism_Homo sapiens_hsa006000.59832496
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.59308955
119Prolactin signaling pathway_Homo sapiens_hsa049170.58258610
120Regulation of autophagy_Homo sapiens_hsa041400.58197153
121Amphetamine addiction_Homo sapiens_hsa050310.55974267
122T cell receptor signaling pathway_Homo sapiens_hsa046600.55573870
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55161318
124Inositol phosphate metabolism_Homo sapiens_hsa005620.55138533
125RNA degradation_Homo sapiens_hsa030180.54762615
126Oxytocin signaling pathway_Homo sapiens_hsa049210.54721820
127mTOR signaling pathway_Homo sapiens_hsa041500.54279484
128Taste transduction_Homo sapiens_hsa047420.54277052
129Long-term depression_Homo sapiens_hsa047300.53997387
130GnRH signaling pathway_Homo sapiens_hsa049120.53788599
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53766652
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53032841
133Ovarian steroidogenesis_Homo sapiens_hsa049130.51389489
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51259188
135Dopaminergic synapse_Homo sapiens_hsa047280.51057794
136Hematopoietic cell lineage_Homo sapiens_hsa046400.50464297
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49709908
138Ras signaling pathway_Homo sapiens_hsa040140.49410909
139Pancreatic secretion_Homo sapiens_hsa049720.49207702
140Estrogen signaling pathway_Homo sapiens_hsa049150.48460878

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