DDI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.96014709
2axonemal dynein complex assembly (GO:0070286)9.82348291
3reproduction (GO:0000003)9.75795790
4epithelial cilium movement (GO:0003351)9.70035260
5motile cilium assembly (GO:0044458)9.62270709
6spermatid development (GO:0007286)9.61734143
7regulation of cilium movement (GO:0003352)8.42707937
8cilium movement (GO:0003341)7.98605036
9phosphatidylethanolamine biosynthetic process (GO:0006646)7.82872083
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.56676595
11single fertilization (GO:0007338)7.53598930
12phosphatidylethanolamine metabolic process (GO:0046337)7.34932514
13sperm capacitation (GO:0048240)7.21011460
14male meiosis (GO:0007140)7.13011265
15piRNA metabolic process (GO:0034587)6.99557568
16synaptonemal complex organization (GO:0070193)6.90941646
17synaptonemal complex assembly (GO:0007130)6.76249828
18negative regulation of inclusion body assembly (GO:0090084)6.76012903
19response to pheromone (GO:0019236)6.75449976
20spermatogenesis (GO:0007283)6.60218131
21male gamete generation (GO:0048232)6.57770366
22organic cation transport (GO:0015695)6.53597701
23microtubule depolymerization (GO:0007019)6.48773151
24fertilization (GO:0009566)6.28801266
25protein targeting to Golgi (GO:0000042)6.24138319
26glucocorticoid biosynthetic process (GO:0006704)6.16151607
27gamete generation (GO:0007276)6.05034917
28establishment of protein localization to Golgi (GO:0072600)6.02950694
29retrograde transport, vesicle recycling within Golgi (GO:0000301)5.92961245
30rRNA methylation (GO:0031167)5.79783991
31regulation of inclusion body assembly (GO:0090083)5.66421292
32calcium ion-dependent exocytosis (GO:0017156)5.61561869
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.40323630
34germ cell development (GO:0007281)5.39982140
35cellular ketone body metabolic process (GO:0046950)5.33416814
36cell recognition (GO:0008037)5.22450111
37spermatid nucleus differentiation (GO:0007289)5.19545393
38ventricular system development (GO:0021591)5.12902150
39chromatin silencing (GO:0006342)5.02387505
40regulation of microtubule-based movement (GO:0060632)4.93761855
41chromosome condensation (GO:0030261)4.83923421
42glycerol ether metabolic process (GO:0006662)4.77489165
43multicellular organismal reproductive process (GO:0048609)4.76147913
44chromosome organization involved in meiosis (GO:0070192)4.74586756
45microtubule severing (GO:0051013)4.73583934
46ketone body metabolic process (GO:1902224)4.70971428
47rRNA modification (GO:0000154)4.68716285
48male meiosis I (GO:0007141)4.62134467
49DNA packaging (GO:0006323)4.58563182
50centriole replication (GO:0007099)4.52908604
51seminiferous tubule development (GO:0072520)4.48647297
52DNA methylation involved in gamete generation (GO:0043046)4.48166526
53protein-DNA complex disassembly (GO:0032986)4.46115772
54nucleosome disassembly (GO:0006337)4.46115772
55protein localization to Golgi apparatus (GO:0034067)4.44002846
56ether metabolic process (GO:0018904)4.41141480
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35245307
58regulation of Rab GTPase activity (GO:0032313)4.26613587
59positive regulation of Rab GTPase activity (GO:0032851)4.26613587
60meiotic nuclear division (GO:0007126)4.18660444
61left/right pattern formation (GO:0060972)4.12050601
62glucocorticoid metabolic process (GO:0008211)4.03615949
63single strand break repair (GO:0000012)4.01689030
64chaperone-mediated protein complex assembly (GO:0051131)4.00048846
65multicellular organismal development (GO:0007275)3.84016569
66sexual reproduction (GO:0019953)3.76479163
67histone H3-K9 demethylation (GO:0033169)3.67369397
68meiosis I (GO:0007127)3.66897488
69regulation of centriole replication (GO:0046599)3.61974066
70negative regulation of gene expression, epigenetic (GO:0045814)3.58191838
71negative regulation of Rho protein signal transduction (GO:0035024)3.49848018
72protein polyglutamylation (GO:0018095)3.48104674
73regulation of phosphoprotein phosphatase activity (GO:0043666)3.47344373
74opsonization (GO:0008228)3.46371513
75regulation of transcription involved in cell fate commitment (GO:0060850)3.44956814
76genitalia morphogenesis (GO:0035112)3.44227628
77regulation of somitogenesis (GO:0014807)3.40902675
78amino-acid betaine transport (GO:0015838)3.38229573
79carnitine transport (GO:0015879)3.38229573
80monoubiquitinated protein deubiquitination (GO:0035520)3.35101199
81sequestering of actin monomers (GO:0042989)3.34743856
82protein K11-linked deubiquitination (GO:0035871)3.33392465
83microtubule polymerization or depolymerization (GO:0031109)3.32563233
84somite rostral/caudal axis specification (GO:0032525)3.30706944
85protein localization to cilium (GO:0061512)3.30096351
86glomerular visceral epithelial cell development (GO:0072015)3.29637172
87regulation of spindle checkpoint (GO:0090231)3.26256542
88carnitine transmembrane transport (GO:1902603)3.23440742
89meiotic cell cycle (GO:0051321)3.20720045
90C21-steroid hormone biosynthetic process (GO:0006700)3.14838567
91glomerular epithelial cell development (GO:0072310)3.12820080
92coenzyme catabolic process (GO:0009109)3.10490759
93synapsis (GO:0007129)3.10363680
94regulation of T-helper 2 cell differentiation (GO:0045628)3.08395020
95oocyte development (GO:0048599)3.07642015
96homeostasis of number of cells within a tissue (GO:0048873)3.03534772
97protein refolding (GO:0042026)3.02951827
98interferon-gamma secretion (GO:0072643)3.00033497
99left/right axis specification (GO:0070986)2.99738047
100positive regulation of macrophage activation (GO:0043032)2.96713588
101polyol catabolic process (GO:0046174)2.96105887
102nucleus organization (GO:0006997)2.95600406
103cerebral cortex neuron differentiation (GO:0021895)2.95110510
104androgen biosynthetic process (GO:0006702)2.93406655
105estrogen biosynthetic process (GO:0006703)2.92624677
106alditol metabolic process (GO:0019400)2.92503315
107peptidyl-threonine dephosphorylation (GO:0035970)2.92180111
108glycolytic process (GO:0006096)2.89541356
109musculoskeletal movement (GO:0050881)2.88140194
110multicellular organismal movement (GO:0050879)2.88140194
111cilium organization (GO:0044782)2.86399822
112mesenchymal cell differentiation involved in kidney development (GO:0072161)2.84437199
113mesenchymal cell differentiation involved in renal system development (GO:2001012)2.84437199
114nucleoside diphosphate phosphorylation (GO:0006165)2.84078710
115mitotic sister chromatid cohesion (GO:0007064)2.83310956
116response to acidic pH (GO:0010447)2.82536177
117microtubule nucleation (GO:0007020)2.81861885
118cilium morphogenesis (GO:0060271)2.81198251
119axoneme assembly (GO:0035082)2.80291739
120nuclear pore complex assembly (GO:0051292)2.79449725
121spinal cord motor neuron differentiation (GO:0021522)2.78957390
122microtubule-based movement (GO:0007018)2.77078166
123cilium assembly (GO:0042384)2.76660081
124cellular component assembly involved in morphogenesis (GO:0010927)2.75877452
125intraciliary transport (GO:0042073)2.73539413
126peptidyl-lysine dimethylation (GO:0018027)2.72320655
127coronary vasculature morphogenesis (GO:0060977)2.71998129
128cranial nerve morphogenesis (GO:0021602)2.71065709
129meiotic cell cycle process (GO:1903046)2.69419427
130RNA localization (GO:0006403)2.68627464
131centriole assembly (GO:0098534)2.62994412
132RNA destabilization (GO:0050779)2.60950131
133GTP biosynthetic process (GO:0006183)2.55100281
134regulation of cilium assembly (GO:1902017)2.55028158
135gene silencing by RNA (GO:0031047)2.49728488
136glycerol metabolic process (GO:0006071)2.48598501
137peptidyl-glutamic acid modification (GO:0018200)2.47583633
138negative regulation of organelle assembly (GO:1902116)2.47108616
139polyamine biosynthetic process (GO:0006596)2.44805070
140quaternary ammonium group transport (GO:0015697)2.44297102
141lactate metabolic process (GO:0006089)2.43438547
142cell wall macromolecule catabolic process (GO:0016998)14.2529863
143cell wall macromolecule metabolic process (GO:0044036)14.2529863
144fusion of sperm to egg plasma membrane (GO:0007342)14.0790834
145sperm motility (GO:0030317)13.5317211
146acrosome assembly (GO:0001675)12.0678368
147acrosome reaction (GO:0007340)12.0515742
148sperm-egg recognition (GO:0035036)11.8617444
149multicellular organism reproduction (GO:0032504)11.4702911
150plasma membrane fusion (GO:0045026)10.7363289
151cell-cell recognition (GO:0009988)10.6970269
152binding of sperm to zona pellucida (GO:0007339)10.5496801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.32501232
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.16648394
3EZH2_22144423_ChIP-Seq_EOC_Human3.79497809
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42485289
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33934628
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.98452986
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93596714
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88453293
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60705248
10VDR_22108803_ChIP-Seq_LS180_Human2.51772314
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48511868
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44720357
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.18763080
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18631196
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.17680298
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11779165
17ZNF274_21170338_ChIP-Seq_K562_Hela2.06899618
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04492483
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01000360
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.00615931
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95675714
22FUS_26573619_Chip-Seq_HEK293_Human1.93504781
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.90078560
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88338335
25DROSHA_22980978_ChIP-Seq_HELA_Human1.86371149
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80317287
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78468836
28* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73662082
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73516229
30STAT1_17558387_ChIP-Seq_HELA_Human1.72736224
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71869801
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.66967728
33AR_25329375_ChIP-Seq_VCAP_Human1.66456018
34FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63843524
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.63366791
36GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.60904409
37KDM2B_26808549_Chip-Seq_REH_Human1.57189165
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56107488
39ERA_21632823_ChIP-Seq_H3396_Human1.56015229
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.54681742
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54202122
42RUNX_20019798_ChIP-Seq_JUKART_Human1.53733835
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.53438780
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52958457
45GATA3_21867929_ChIP-Seq_CD8_Mouse1.52323259
46TP53_18474530_ChIP-ChIP_U2OS_Human1.48617145
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.47992702
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.47131820
49P300_19829295_ChIP-Seq_ESCs_Human1.46941432
50NANOG_20526341_ChIP-Seq_ESCs_Human1.46322906
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45551880
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45334613
53CBP_20019798_ChIP-Seq_JUKART_Human1.45334613
54ER_23166858_ChIP-Seq_MCF-7_Human1.44760192
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44168743
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.44163315
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43549460
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41720652
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.41213624
60AR_21572438_ChIP-Seq_LNCaP_Human1.40227218
61LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38225966
62CTCF_27219007_Chip-Seq_Bcells_Human1.36444597
63RAC3_21632823_ChIP-Seq_H3396_Human1.33287362
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33116270
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31901807
66* OCT4_20526341_ChIP-Seq_ESCs_Human1.31539691
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31055101
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.30779920
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30630261
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28901981
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.28554396
72SMAD4_21799915_ChIP-Seq_A2780_Human1.28230425
73FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28220046
74SMRT_27268052_Chip-Seq_Bcells_Human1.28203846
75REST_21632747_ChIP-Seq_MESCs_Mouse1.28148802
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27435061
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.26028499
78GF1_26923725_Chip-Seq_HPCs_Mouse1.26013668
79BCL6_27268052_Chip-Seq_Bcells_Human1.25589052
80TP63_22573176_ChIP-Seq_HFKS_Human1.24400394
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24173423
82SMC4_20622854_ChIP-Seq_HELA_Human1.23707346
83STAT3_23295773_ChIP-Seq_U87_Human1.23644022
84BCOR_27268052_Chip-Seq_Bcells_Human1.22919514
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.21703851
86TAF2_19829295_ChIP-Seq_ESCs_Human1.21457607
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.21376923
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21335896
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21207701
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21038857
91PHF8_20622854_ChIP-Seq_HELA_Human1.20342508
92* P53_21459846_ChIP-Seq_SAOS-2_Human1.19367942
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.18443478
94P300_27268052_Chip-Seq_Bcells_Human1.16863166
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16518885
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15372549
97CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15214863
98TBL1_22424771_ChIP-Seq_293T_Human1.14952985
99OCT1_27270436_Chip-Seq_PROSTATE_Human1.14706637
100RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14701483
101* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14579565
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14050430
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13612107
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13267743
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13267743
106RBPJ_21746931_ChIP-Seq_IB4_Human1.13099297
107CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13090567
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12622072
109VDR_24787735_ChIP-Seq_THP-1_Human1.12588175
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12210105
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11996246
112HNFA_21074721_ChIP-Seq_CACO-2_Human1.11874186
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.11576332
114CEBPB_22108803_ChIP-Seq_LS180_Human1.10568929
115SMAD4_21741376_ChIP-Seq_HESCs_Human1.10515544
116TAF15_26573619_Chip-Seq_HEK293_Human1.10474958
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.10443147
118ETV1_20927104_ChIP-Seq_GIST48_Human1.10011921
119E2F1_20622854_ChIP-Seq_HELA_Human1.08440436
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08425451
121P53_22387025_ChIP-Seq_ESCs_Mouse1.08144149
122SPI1_26923725_Chip-Seq_HPCs_Mouse1.07699651
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07637530
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.07580999
125CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07107064
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06933173
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06072678
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05786935
129MYC_19829295_ChIP-Seq_ESCs_Human1.04850190
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.04663752
131P68_20966046_ChIP-Seq_HELA_Human1.04213952
132P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04128068
133RUNX2_22187159_ChIP-Seq_PCA_Human1.03883803
134ESET_19884257_ChIP-Seq_ESCs_Mouse1.03200199
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.02999530
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02995513
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02866190
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.02666032
139TCF4_23295773_ChIP-Seq_U87_Human1.02513546
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02445019
141KLF4_18555785_Chip-Seq_ESCs_Mouse1.01538456
142GATA3_21878914_ChIP-Seq_MCF-7_Human1.01525418
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01457070
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01281734
145* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01001797
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00608036
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00243934
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00082275
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99800700
150RNF2_27304074_Chip-Seq_NSC_Mouse0.99637258
151P300_18555785_Chip-Seq_ESCs_Mouse0.99495008
152CJUN_26792858_Chip-Seq_BT549_Human0.99434041
153* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99299032
154GBX2_23144817_ChIP-Seq_PC3_Human0.98759483
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.98606394
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98570192
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98386586
158LXR_22292898_ChIP-Seq_THP-1_Human0.98112413
159ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98042100
160* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97776885
161* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97698497
162ERG_20517297_ChIP-Seq_VCAP_Human0.96923968
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.96908316
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96519938
165GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96416971
166* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95189777
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94583079
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93937929
169SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93690267
170GF1B_26923725_Chip-Seq_HPCs_Mouse0.92441354
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91629022
172JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91445732
173SOX9_26525672_Chip-Seq_HEART_Mouse0.91117214
174KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90633408
175FLI1_21867929_ChIP-Seq_CD8_Mouse0.89827654
176PU1_27457419_Chip-Seq_LIVER_Mouse0.89812438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07073881
2MP0001929_abnormal_gametogenesis5.51570550
3MP0008877_abnormal_DNA_methylation4.13838131
4MP0002210_abnormal_sex_determination3.38364152
5MP0002161_abnormal_fertility/fecundity3.26646575
6MP0009697_abnormal_copulation3.15472262
7MP0005670_abnormal_white_adipose2.88342740
8MP0001145_abnormal_male_reproductive2.88236601
9MP0001348_abnormal_lacrimal_gland2.69370856
10MP0002653_abnormal_ependyma_morphology2.53110408
11MP0000653_abnormal_sex_gland2.49676797
12MP0010386_abnormal_urinary_bladder2.23550928
13MP0005379_endocrine/exocrine_gland_phen2.09938936
14MP0002735_abnormal_chemical_nociception2.04112691
15MP0005410_abnormal_fertilization16.4933641
16MP0005310_abnormal_salivary_gland1.97428507
17MP0000678_abnormal_parathyroid_gland1.88069780
18MP0002160_abnormal_reproductive_system1.76507908
19MP0001485_abnormal_pinna_reflex1.66365839
20MP0004233_abnormal_muscle_weight1.61330719
21MP0005623_abnormal_meninges_morphology1.58624121
22MP0004084_abnormal_cardiac_muscle1.57788262
23MP0002127_abnormal_cardiovascular_syste1.56606061
24MP0003646_muscle_fatigue1.44717502
25MP0001986_abnormal_taste_sensitivity1.36702818
26MP0002282_abnormal_trachea_morphology1.31243152
27MP0004510_myositis1.29860308
28MP0002249_abnormal_larynx_morphology1.29296429
29MP0002132_abnormal_respiratory_system1.27409163
30MP0005647_abnormal_sex_gland1.21598547
31MP0004484_altered_response_of1.15183582
32MP0001879_abnormal_lymphatic_vessel1.14406355
33MP0003718_maternal_effect1.12938717
34MP0002822_catalepsy1.10567041
35MP0001984_abnormal_olfaction1.10451192
36MP0003123_paternal_imprinting1.09307732
37MP0001765_abnormal_ion_homeostasis1.09202531
38MP0010368_abnormal_lymphatic_system1.08339168
39MP0002234_abnormal_pharynx_morphology1.03036363
40MP0001486_abnormal_startle_reflex1.01539485
41MP0008004_abnormal_stomach_pH1.01438788
42MP0001963_abnormal_hearing_physiology1.00008904
43MP0004043_abnormal_pH_regulation0.99282143
44MP0009046_muscle_twitch0.97909009
45MP0008058_abnormal_DNA_repair0.93449454
46MP0000639_abnormal_adrenal_gland0.93315521
47MP0000537_abnormal_urethra_morphology0.90738295
48MP0005389_reproductive_system_phenotype0.88583910
49MP0004085_abnormal_heartbeat0.88329789
50MP0000026_abnormal_inner_ear0.88073287
51MP0009053_abnormal_anal_canal0.85839444
52MP0002837_dystrophic_cardiac_calcinosis0.84831390
53MP0002229_neurodegeneration0.79520673
54MP0005451_abnormal_body_composition0.76618143
55MP0008995_early_reproductive_senescence0.75685414
56MP0005248_abnormal_Harderian_gland0.72990430
57MP0002067_abnormal_sensory_capabilities0.70158008
58MP0003115_abnormal_respiratory_system0.70104997
59MP0005167_abnormal_blood-brain_barrier0.66178813
60MP0003011_delayed_dark_adaptation0.64954922
61MP0000249_abnormal_blood_vessel0.63526453
62MP0005395_other_phenotype0.63290814
63MP0000613_abnormal_salivary_gland0.62713268
64MP0000681_abnormal_thyroid_gland0.61235871
65MP0000470_abnormal_stomach_morphology0.60067652
66MP0002928_abnormal_bile_duct0.57775376
67MP0000230_abnormal_systemic_arterial0.57752434
68MP0005666_abnormal_adipose_tissue0.57124316
69MP0005636_abnormal_mineral_homeostasis0.55256165
70MP0000538_abnormal_urinary_bladder0.54117246
71MP0006292_abnormal_olfactory_placode0.53817627
72MP0002557_abnormal_social/conspecific_i0.51904595
73MP0002269_muscular_atrophy0.51118476
74MP0002102_abnormal_ear_morphology0.51068322
75MP0001324_abnormal_eye_pigmentation0.50301232
76MP0002733_abnormal_thermal_nociception0.49599632
77MP0001970_abnormal_pain_threshold0.49595497
78MP0005377_hearing/vestibular/ear_phenot0.49487662
79MP0003878_abnormal_ear_physiology0.49487662
80MP0003936_abnormal_reproductive_system0.48586618
81MP0004036_abnormal_muscle_relaxation0.46992034
82MP0001764_abnormal_homeostasis0.46273956
83MP0000631_abnormal_neuroendocrine_gland0.44293170
84MP0003699_abnormal_female_reproductive0.43881528
85MP0002115_abnormal_skeleton_extremities0.43855802
86MP0000049_abnormal_middle_ear0.42503937
87MP0001293_anophthalmia0.42327453
88MP0004264_abnormal_extraembryonic_tissu0.41980514
89MP0005408_hypopigmentation0.41964163
90MP0010094_abnormal_chromosome_stability0.41954534
91MP0009115_abnormal_fat_cell0.41383234
92MP0002971_abnormal_brown_adipose0.40820252
93MP0004133_heterotaxia0.40469675
94MP0005083_abnormal_biliary_tract0.40451753
95MP0003950_abnormal_plasma_membrane0.40046376
96MP0000358_abnormal_cell_content/0.39628901
97MP0005551_abnormal_eye_electrophysiolog0.38806377
98MP0003091_abnormal_cell_migration0.38488693
99MP0003137_abnormal_impulse_conducting0.38187675
100MP0005275_abnormal_skin_tensile0.37983940
101MP0003329_amyloid_beta_deposits0.37817480
102MP0008057_abnormal_DNA_replication0.37397850
103MP0009745_abnormal_behavioral_response0.36658055
104MP0002090_abnormal_vision0.35213817
105MP0008569_lethality_at_weaning0.35024006
106MP0005595_abnormal_vascular_smooth0.34914652
107MP0005253_abnormal_eye_physiology0.34780288
108MP0000534_abnormal_ureter_morphology0.34158046
109MP0002796_impaired_skin_barrier0.32216179
110MP0006036_abnormal_mitochondrial_physio0.32189885
111MP0003633_abnormal_nervous_system0.30156858
112MP0009278_abnormal_bone_marrow0.30041828
113MP0005397_hematopoietic_system_phenotyp0.29137857
114MP0001545_abnormal_hematopoietic_system0.29137857
115MP0003942_abnormal_urinary_system0.27767816
116MP0001119_abnormal_female_reproductive0.27652047
117MP0003045_fibrosis0.26778991
118MP0005391_vision/eye_phenotype0.26746592
119MP0000569_abnormal_digit_pigmentation0.26293739
120MP0002736_abnormal_nociception_after0.26025228
121MP0003861_abnormal_nervous_system0.25346744
122MP0004019_abnormal_vitamin_homeostasis0.24936731
123MP0003948_abnormal_gas_homeostasis0.23452292
124MP0003786_premature_aging0.23278167
125MP0003959_abnormal_lean_body0.23069621
126MP0010307_abnormal_tumor_latency0.22379765
127MP0003111_abnormal_nucleus_morphology0.21792858
128MP0002152_abnormal_brain_morphology0.21551277
129MP0004811_abnormal_neuron_physiology0.21280221
130MP0003631_nervous_system_phenotype0.20866857
131MP0002108_abnormal_muscle_morphology0.20595561
132MP0005503_abnormal_tendon_morphology0.19499104
133MP0001730_embryonic_growth_arrest0.18416926
134MP0002169_no_abnormal_phenotype0.18338794
135MP0003879_abnormal_hair_cell0.18334376
136MP0003787_abnormal_imprinting0.18124839
137MP0002873_normal_phenotype0.18090243
138MP0005375_adipose_tissue_phenotype0.17754789
139MP0002139_abnormal_hepatobiliary_system0.16952948
140MP0008875_abnormal_xenobiotic_pharmacok0.16279555
141MP0002295_abnormal_pulmonary_circulatio0.15919001
142MP0001849_ear_inflammation0.15517144
143MP0002405_respiratory_system_inflammati0.14792281
144MP0006035_abnormal_mitochondrial_morpho0.14344854
145MP0002084_abnormal_developmental_patter0.14176122
146MP0001727_abnormal_embryo_implantation0.13932325
147MP0002092_abnormal_eye_morphology0.13631323
148MP0001661_extended_life_span0.13536493
149MP0008961_abnormal_basal_metabolism0.13520844
150MP0000604_amyloidosis0.12898205
151MP0004742_abnormal_vestibular_system0.12225125
152MP0005195_abnormal_posterior_eye0.12203510
153MP0001968_abnormal_touch/_nociception0.11991976
154MP0000751_myopathy0.11991098
155MP0005423_abnormal_somatic_nervous0.11973775
156MP0000001_mammalian_phenotype0.11710404
157MP0005535_abnormal_body_temperature0.11379180
158MP0002168_other_aberrant_phenotype0.11342011
159MP0002118_abnormal_lipid_homeostasis0.10674008

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.33070867
2Abnormal respiratory epithelium morphology (HP:0012253)9.23700559
3Abnormal respiratory motile cilium morphology (HP:0005938)9.23700559
4Rhinitis (HP:0012384)7.59904505
5Abnormal ciliary motility (HP:0012262)7.37975739
6Chronic bronchitis (HP:0004469)7.31480419
7Severe visual impairment (HP:0001141)7.19140594
8Infertility (HP:0000789)6.77015164
9Nasal polyposis (HP:0100582)6.43993945
10Abnormality of the nasal mucosa (HP:0000433)5.28952646
11Chronic hepatic failure (HP:0100626)4.63471869
12Hyperkalemia (HP:0002153)4.60150941
13Bronchitis (HP:0012387)4.59146143
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.58792983
15Male infertility (HP:0003251)4.51411440
16Bronchiectasis (HP:0002110)4.44922374
17Bony spicule pigmentary retinopathy (HP:0007737)4.36365862
18Attenuation of retinal blood vessels (HP:0007843)4.08019902
19Nephronophthisis (HP:0000090)4.07952333
20Resting tremor (HP:0002322)3.97489173
21Abnormal rod and cone electroretinograms (HP:0008323)3.81961930
22Hypoplasia of the thymus (HP:0000778)3.78065744
23Abnormal spermatogenesis (HP:0008669)3.59137291
24Potter facies (HP:0002009)3.55745926
25Facial shape deformation (HP:0011334)3.55745926
26Hypoalphalipoproteinemia (HP:0003233)3.39380575
27Recurrent sinusitis (HP:0011108)3.32637975
28Abnormality of macular pigmentation (HP:0008002)3.32232245
29Cone-rod dystrophy (HP:0000548)3.27505989
30Recurrent otitis media (HP:0000403)3.24910454
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.20668288
32Decreased circulating renin level (HP:0003351)3.17981499
33Abnormality of the renal medulla (HP:0100957)3.11820210
34Abnormality of potassium homeostasis (HP:0011042)3.11018015
35Abnormality of the aortic arch (HP:0012303)3.03943868
36Truncal obesity (HP:0001956)2.94384858
37Postural instability (HP:0002172)2.87194287
38Medial flaring of the eyebrow (HP:0010747)2.83186194
39Recurrent bronchitis (HP:0002837)2.77589959
40Hypoplastic ischia (HP:0003175)2.70203550
41Menstrual irregularities (HP:0000858)2.67060107
42Tubulointerstitial nephritis (HP:0001970)2.65568338
43Impulsivity (HP:0100710)2.64145736
44Ventricular tachycardia (HP:0004756)2.62727302
45Progressive sensorineural hearing impairment (HP:0000408)2.61274904
46Hyperaldosteronism (HP:0000859)2.58434599
47Molar tooth sign on MRI (HP:0002419)2.58044684
48Abnormality of midbrain morphology (HP:0002418)2.58044684
49Tubular atrophy (HP:0000092)2.57012021
50Abnormality of the ischium (HP:0003174)2.56980233
51Renal salt wasting (HP:0000127)2.55721277
52Progressive cerebellar ataxia (HP:0002073)2.48660490
53Azoospermia (HP:0000027)2.40609799
54Portal hypertension (HP:0001409)2.39680096
55Tubulointerstitial abnormality (HP:0001969)2.37300444
56Congenital sensorineural hearing impairment (HP:0008527)2.28149195
57Hypokalemic alkalosis (HP:0001949)2.27085453
58Atrial fibrillation (HP:0005110)2.25136357
59Hypokalemia (HP:0002900)2.22852421
60Cholecystitis (HP:0001082)2.22796676
61Abnormal gallbladder physiology (HP:0012438)2.22796676
62Abnormality of the parathyroid morphology (HP:0011766)2.22480855
63Gonadotropin excess (HP:0000837)2.20858101
64Abnormality of the hepatic vasculature (HP:0006707)2.17884449
65Accelerated skeletal maturation (HP:0005616)2.12355659
66Recurrent pneumonia (HP:0006532)2.10285555
67Amelogenesis imperfecta (HP:0000705)2.08883540
68Insulin-resistant diabetes mellitus (HP:0000831)2.07061534
69Primary atrial arrhythmia (HP:0001692)2.05708373
70Polyuria (HP:0000103)2.03106372
71Abnormality of chloride homeostasis (HP:0011422)2.01273548
72Tubulointerstitial fibrosis (HP:0005576)2.00074051
73Dynein arm defect of respiratory motile cilia (HP:0012255)13.2563804
74Absent/shortened dynein arms (HP:0200106)13.2563804
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2460648
76Renovascular hypertension (HP:0100817)1.97690582
77Decreased central vision (HP:0007663)1.95246025
78Abnormality of the epiphysis of the femoral head (HP:0010574)1.94521750
79Abnormality of dental color (HP:0011073)1.94082284
80Enlarged epiphyses (HP:0010580)1.92314496
81Dyschromatopsia (HP:0007641)1.91549630
82Male pseudohermaphroditism (HP:0000037)1.91153458
83Supraventricular tachycardia (HP:0004755)1.89014349
84Spastic tetraparesis (HP:0001285)1.87565732
85Unilateral renal agenesis (HP:0000122)1.86257929
86Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.84050795
87Abnormality of femoral epiphyses (HP:0006499)1.84050795
88Distal lower limb muscle weakness (HP:0009053)1.83845724
89Upper limb muscle weakness (HP:0003484)1.82997756
90Supraventricular arrhythmia (HP:0005115)1.82627404
91Postaxial foot polydactyly (HP:0001830)1.80498270
92Congenital primary aphakia (HP:0007707)1.79769750
93Slow saccadic eye movements (HP:0000514)1.79534378
94Gait imbalance (HP:0002141)1.79432350
95Abnormal connection of the cardiac segments (HP:0011545)1.77534126
96Abnormal ventriculo-arterial connection (HP:0011563)1.77534126
97Transposition of the great arteries (HP:0001669)1.77534126
98Flattened epiphyses (HP:0003071)1.77470448
99Choroideremia (HP:0001139)1.76415552
100Gingivitis (HP:0000230)1.75729922
101Heterotopia (HP:0002282)1.75424799
102Congenital hepatic fibrosis (HP:0002612)1.75365584
103Stage 5 chronic kidney disease (HP:0003774)1.75285339
104Thickened helices (HP:0000391)1.74226374
105Flat capital femoral epiphysis (HP:0003370)1.73315765
106Aplasia/Hypoplasia of the lens (HP:0008063)1.72680317
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71313717
108Syncope (HP:0001279)1.70838679
109Abnormality of the femoral head (HP:0003368)1.70686524
110Polydipsia (HP:0001959)1.69939362
111Abnormal drinking behavior (HP:0030082)1.69939362
112Abnormality of the renal cortex (HP:0011035)1.67668313
113Chronic sinusitis (HP:0011109)1.64420476
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63724822
115Abnormality of renal excretion (HP:0011036)1.57982247
116Renal dysplasia (HP:0000110)1.57361033
117Abnormal biliary tract physiology (HP:0012439)1.54263477
118Bile duct proliferation (HP:0001408)1.54263477
119Postaxial hand polydactyly (HP:0001162)1.54143673
120Fibular hypoplasia (HP:0003038)1.53795852
121Short ribs (HP:0000773)1.52397656
122Facial cleft (HP:0002006)1.52181411
123Nephrogenic diabetes insipidus (HP:0009806)1.51364509
124Bell-shaped thorax (HP:0001591)1.50502649
125Easy fatigability (HP:0003388)1.49766501
126Hemorrhage of the eye (HP:0011885)1.48902302
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.47683910
128Oculomotor apraxia (HP:0000657)1.44045137
129Vaginal atresia (HP:0000148)1.41922453
130Congenital malformation of the right heart (HP:0011723)1.41714425
131Double outlet right ventricle (HP:0001719)1.41714425
132Fatigable weakness (HP:0003473)1.41431352
133Abnormality of the neuromuscular junction (HP:0003398)1.41431352
134Genital tract atresia (HP:0001827)1.40812166
135Abnormality of permanent molar morphology (HP:0011071)1.39765508
136Abnormality of the dental root (HP:0006486)1.39765508
137Taurodontia (HP:0000679)1.39765508
138Cerebellar dysplasia (HP:0007033)1.39119029
139Bundle branch block (HP:0011710)1.38308294
140Cystic liver disease (HP:0006706)1.37107975
141Abnormality of dentin (HP:0010299)1.36316817
142Abnormality of saccadic eye movements (HP:0000570)1.36291226
143Poor coordination (HP:0002370)1.33133175
144Abnormality of the dental pulp (HP:0006479)1.32204236
145Abnormality of molar (HP:0011077)1.31190175
146Abnormality of molar morphology (HP:0011070)1.31190175
147Asymmetric septal hypertrophy (HP:0001670)1.30817834
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.30677887
149Neurofibrillary tangles (HP:0002185)1.30561730
150Pancreatic fibrosis (HP:0100732)1.29571046
151Abnormal urine output (HP:0012590)1.29174617
152Microglossia (HP:0000171)1.27689572
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27610981
154Absent epiphyses (HP:0010577)1.27610981
155Abnormality of the lower motor neuron (HP:0002366)1.24307154
156Abnormality of ocular smooth pursuit (HP:0000617)1.24028945
157Hemiparesis (HP:0001269)1.23387817
158Deformed sella turcica (HP:0002681)1.21774347
159Absent frontal sinuses (HP:0002688)1.20608256
160Sensory axonal neuropathy (HP:0003390)1.20531859
161Tongue fasciculations (HP:0001308)1.19621245
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.19152684
163Type 2 muscle fiber atrophy (HP:0003554)1.18251999
164Median cleft lip (HP:0000161)1.16903853
165Loss of speech (HP:0002371)1.16812176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.11884431
2PDK38.11884431
3TESK16.33842676
4LATS15.64238579
5PDK25.25430624
6PRKD35.18972330
7ICK4.47529168
8BLK3.75123710
9AKT33.38804195
10MAP4K23.27028927
11DDR23.06765823
12CAMK1D2.45539056
13NUAK12.27689921
14PTK2B2.27266506
15WNK42.13764762
16STK392.12753102
17PLK22.06290838
18BRD41.95515856
19PIK3CG1.95319297
20INSRR1.90747454
21STK381.89310295
22PNCK1.75376463
23DYRK1B1.70612452
24NEK21.61015280
25MST1R1.28276375
26PDK11.15527356
27JAK31.11260014
28FRK1.10595221
29DYRK31.08591381
30SIK21.04881900
31IRAK10.90699622
32CAMK40.90532576
33PRKAA20.89534147
34ITK0.87271129
35CAMK10.86791864
36MAPK150.85069396
37TYRO30.83651414
38PKN20.77062391
39WNK10.75572916
40CDK70.73716259
41MAP3K90.73551186
42STK30.73110588
43LMTK20.70741267
44PDPK10.70117613
45MAP2K20.69317433
46MAP4K10.68660965
47PASK0.66623398
48TESK20.63340041
49STK38L0.63301735
50CHEK20.62479732
51CCNB10.61404713
52SGK4940.60749102
53SGK2230.60749102
54RIPK40.58536504
55OXSR10.57624273
56ACVR1B0.55491702
57TTK0.54465545
58PINK10.54013325
59GRK70.53124891
60NTRK30.52632307
61MAP2K60.51543427
62EEF2K0.49955471
63CAMK1G0.49432899
64MAP3K20.48027343
65SGK20.47605028
66MUSK0.46249360
67PLK40.44837483
68CDK30.44795115
69SYK0.43192077
70IRAK20.41714037
71BTK0.41552954
72MAPK110.41442367
73NTRK20.40537150
74SGK10.38754076
75CHEK10.37963190
76MAPK10.37589576
77PAK10.37421269
78KSR20.33256770
79PRKCG0.32606116
80WEE10.30573530
81RPS6KA20.29978788
82MAP3K110.29012325
83RPS6KA60.28958339
84RPS6KC10.28938709
85RPS6KL10.28938709
86ATM0.28367135
87NEK90.27183721
88CDK40.27178644
89BRSK20.26698528
90PAK20.26319810
91MTOR0.26307430
92ROCK10.25448049
93TEC0.25375735
94ATR0.23868084
95CDK120.23796972
96MAP3K70.23437314
97MARK20.21998640
98RPS6KA50.21327550
99MELK0.21166096
100PRKCQ0.20665119
101ZAK0.20324089
102PAK40.19474147
103MAPKAPK50.19365793
104NEK60.19298422
105MARK30.19166357
106PKN10.19158110
107PRKAA10.18710972
108JAK20.17173377
109MAP3K10.16508507
110PRKCZ0.15829352
111MAP3K100.15293084
112CAMKK10.15271488
113MAP3K80.14718406
114STK100.14563896
115GRK50.14420386
116BRSK10.13859723
117RPS6KB10.13846153
118SGK30.13304405
119AKT10.13272598
120UHMK10.13134390
121PLK10.12335771
122PRKG20.12107086
123CDC70.10050020
124RPS6KA10.08767905
125CDK150.08714244
126CSNK2A10.08570609
127YES10.08245845
128GSK3B0.07754606
129CDK180.06751503
130PRKG10.06713051
131BRAF0.05599560
132PRKACG0.05445442
133BMPR1B0.05444750
134CDK11A0.05321388
135CDK60.05238864
136CSNK1D0.04306029
137RIPK10.04074028
138CAMK2A0.03816801
139CSNK2A20.03240681
140PRKCD0.03021914
141STK110.02816323
142EGFR0.02589076
143PIM10.02543359
144MAPK80.02135846
145CDK10.02039129
146CDK140.01846072
147CSF1R0.01640780
148ZAP700.01594869
149CDK20.01522523
150PRKCA0.01190063
151PDGFRB0.01189904
152PRKCB0.00955996
153OBSCN-0.0341969
154AURKA-0.0321389
155PRKACB-0.0267815
156EPHB1-0.0193841
157PRKDC-0.0188600
158CLK1-0.0145503
159PRKACA-0.0136929

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.04120018
2Fatty acid biosynthesis_Homo sapiens_hsa000614.59475342
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.28992704
4Vitamin B6 metabolism_Homo sapiens_hsa007503.50673970
5Pyruvate metabolism_Homo sapiens_hsa006203.40894617
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.11926062
7Linoleic acid metabolism_Homo sapiens_hsa005913.03721434
8Propanoate metabolism_Homo sapiens_hsa006402.71776674
9Glucagon signaling pathway_Homo sapiens_hsa049222.61821963
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.50491191
11Olfactory transduction_Homo sapiens_hsa047402.47417867
12Basal transcription factors_Homo sapiens_hsa030222.46228658
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.22544610
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11607781
15Selenocompound metabolism_Homo sapiens_hsa004502.11055685
16Glycerolipid metabolism_Homo sapiens_hsa005612.06470386
17PPAR signaling pathway_Homo sapiens_hsa033201.97912425
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90894139
19Pentose phosphate pathway_Homo sapiens_hsa000301.84769231
20Butanoate metabolism_Homo sapiens_hsa006501.82552494
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.74307974
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73866801
23Ovarian steroidogenesis_Homo sapiens_hsa049131.69797734
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69080916
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.67060115
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.67010853
27Oocyte meiosis_Homo sapiens_hsa041141.63971448
28Amphetamine addiction_Homo sapiens_hsa050311.57872893
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55049833
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53440547
31Fat digestion and absorption_Homo sapiens_hsa049751.50239743
32Dorso-ventral axis formation_Homo sapiens_hsa043201.47879273
33Fructose and mannose metabolism_Homo sapiens_hsa000511.47058648
34Graft-versus-host disease_Homo sapiens_hsa053321.44848623
35Fatty acid metabolism_Homo sapiens_hsa012121.44064533
36Mineral absorption_Homo sapiens_hsa049781.42784412
37Fatty acid degradation_Homo sapiens_hsa000711.41992494
38Ether lipid metabolism_Homo sapiens_hsa005651.38904602
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35638008
40Allograft rejection_Homo sapiens_hsa053301.34650649
41Fanconi anemia pathway_Homo sapiens_hsa034601.34199385
42Cardiac muscle contraction_Homo sapiens_hsa042601.31719686
43Carbon metabolism_Homo sapiens_hsa012001.31214633
44Type II diabetes mellitus_Homo sapiens_hsa049301.30380450
45Autoimmune thyroid disease_Homo sapiens_hsa053201.30089371
46Viral myocarditis_Homo sapiens_hsa054161.22066765
47Type I diabetes mellitus_Homo sapiens_hsa049401.18023612
48Renin secretion_Homo sapiens_hsa049241.10696801
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09353272
50Huntingtons disease_Homo sapiens_hsa050161.07819796
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.07352244
52Antigen processing and presentation_Homo sapiens_hsa046121.05150203
53Prolactin signaling pathway_Homo sapiens_hsa049171.04713705
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01025349
55Collecting duct acid secretion_Homo sapiens_hsa049660.98021608
56Purine metabolism_Homo sapiens_hsa002300.96983914
57Glutathione metabolism_Homo sapiens_hsa004800.96548756
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93770379
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92328848
60B cell receptor signaling pathway_Homo sapiens_hsa046620.90152983
61mRNA surveillance pathway_Homo sapiens_hsa030150.89405662
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87356282
63Hedgehog signaling pathway_Homo sapiens_hsa043400.86393924
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.84230274
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.82128619
66Arachidonic acid metabolism_Homo sapiens_hsa005900.81119402
67Biosynthesis of amino acids_Homo sapiens_hsa012300.81073815
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80008183
69Renin-angiotensin system_Homo sapiens_hsa046140.78469272
70Chemical carcinogenesis_Homo sapiens_hsa052040.78117163
71Insulin secretion_Homo sapiens_hsa049110.78065462
72Cholinergic synapse_Homo sapiens_hsa047250.73680369
73RNA transport_Homo sapiens_hsa030130.72736168
74Nicotine addiction_Homo sapiens_hsa050330.71996811
75Thyroid hormone synthesis_Homo sapiens_hsa049180.71187696
76Staphylococcus aureus infection_Homo sapiens_hsa051500.70939115
77Morphine addiction_Homo sapiens_hsa050320.70074095
78Dilated cardiomyopathy_Homo sapiens_hsa054140.69091523
79Long-term potentiation_Homo sapiens_hsa047200.68947238
80Bile secretion_Homo sapiens_hsa049760.67719963
81Systemic lupus erythematosus_Homo sapiens_hsa053220.67633716
82Estrogen signaling pathway_Homo sapiens_hsa049150.67449512
83Influenza A_Homo sapiens_hsa051640.67168608
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65378850
85Tyrosine metabolism_Homo sapiens_hsa003500.63917054
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61683272
87ABC transporters_Homo sapiens_hsa020100.61377347
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60213172
89Serotonergic synapse_Homo sapiens_hsa047260.59216036
90Toxoplasmosis_Homo sapiens_hsa051450.59093842
91Calcium signaling pathway_Homo sapiens_hsa040200.57488693
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55870220
93Pancreatic secretion_Homo sapiens_hsa049720.54768725
94Inositol phosphate metabolism_Homo sapiens_hsa005620.53966594
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53878419
96Gap junction_Homo sapiens_hsa045400.52766067
97Protein digestion and absorption_Homo sapiens_hsa049740.52212094
98ECM-receptor interaction_Homo sapiens_hsa045120.52149840
99Synaptic vesicle cycle_Homo sapiens_hsa047210.51766041
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51186188
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50920547
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50133492
103Lysine degradation_Homo sapiens_hsa003100.49768573
104Endocytosis_Homo sapiens_hsa041440.49274392
105Phototransduction_Homo sapiens_hsa047440.48445333
106Prostate cancer_Homo sapiens_hsa052150.47738568
107Salivary secretion_Homo sapiens_hsa049700.47723166
108Legionellosis_Homo sapiens_hsa051340.47183571
109Platelet activation_Homo sapiens_hsa046110.47173415
110Acute myeloid leukemia_Homo sapiens_hsa052210.47161761
111AMPK signaling pathway_Homo sapiens_hsa041520.47012888
112Phenylalanine metabolism_Homo sapiens_hsa003600.46072825
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45545233
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45426365
115MAPK signaling pathway_Homo sapiens_hsa040100.45263405
116FoxO signaling pathway_Homo sapiens_hsa040680.45037499
117Arginine biosynthesis_Homo sapiens_hsa002200.44654700
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.44413011
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.44364212
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.41626937
121Focal adhesion_Homo sapiens_hsa045100.41315465
122Metabolic pathways_Homo sapiens_hsa011000.39896069
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39858490
124Taste transduction_Homo sapiens_hsa047420.38630982
125Sulfur metabolism_Homo sapiens_hsa009200.38547315
126Gastric acid secretion_Homo sapiens_hsa049710.37808890
127N-Glycan biosynthesis_Homo sapiens_hsa005100.36529405
128Oxytocin signaling pathway_Homo sapiens_hsa049210.36141277
129mTOR signaling pathway_Homo sapiens_hsa041500.35568166
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34364913
131cAMP signaling pathway_Homo sapiens_hsa040240.32141027
132Retinol metabolism_Homo sapiens_hsa008300.29080444
133VEGF signaling pathway_Homo sapiens_hsa043700.28022197
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27613436
135Circadian entrainment_Homo sapiens_hsa047130.27324589
136Alcoholism_Homo sapiens_hsa050340.26616700
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25932760
138Cocaine addiction_Homo sapiens_hsa050300.22102512
139Basal cell carcinoma_Homo sapiens_hsa052170.21123547
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18750453
141Pyrimidine metabolism_Homo sapiens_hsa002400.17441467
142Wnt signaling pathway_Homo sapiens_hsa043100.14515961
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12594745
144Insulin resistance_Homo sapiens_hsa049310.07788303
145Viral carcinogenesis_Homo sapiens_hsa052030.06996563
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06504865
147Salmonella infection_Homo sapiens_hsa051320.05197762

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