DDI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.68803604
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.68803604
3nuclear pore complex assembly (GO:0051292)6.48908201
4L-phenylalanine metabolic process (GO:0006558)6.41274883
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.41274883
6aromatic amino acid family catabolic process (GO:0009074)6.13746929
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91609065
8kynurenine metabolic process (GO:0070189)5.77101176
9indole-containing compound catabolic process (GO:0042436)5.70441659
10indolalkylamine catabolic process (GO:0046218)5.70441659
11tryptophan catabolic process (GO:0006569)5.70441659
12urea metabolic process (GO:0019627)5.70336925
13urea cycle (GO:0000050)5.70336925
14nuclear pore organization (GO:0006999)5.56953737
15alpha-linolenic acid metabolic process (GO:0036109)5.49755055
16regulation of RNA export from nucleus (GO:0046831)5.43436755
17tryptophan metabolic process (GO:0006568)5.41885203
18bile acid biosynthetic process (GO:0006699)5.39198870
19glyoxylate metabolic process (GO:0046487)5.30598091
20negative regulation of fibrinolysis (GO:0051918)5.26806540
21cysteine metabolic process (GO:0006534)5.21928299
22complement activation, alternative pathway (GO:0006957)5.21579410
23peptidyl-glutamic acid carboxylation (GO:0017187)5.18853613
24protein carboxylation (GO:0018214)5.18853613
25regulation of protein activation cascade (GO:2000257)5.16543732
26nitrogen cycle metabolic process (GO:0071941)5.14020693
27high-density lipoprotein particle remodeling (GO:0034375)5.10520000
28sulfur amino acid catabolic process (GO:0000098)5.07520231
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94839234
30serine family amino acid catabolic process (GO:0009071)4.93450278
31regulation of fibrinolysis (GO:0051917)4.92353782
32regulation of complement activation (GO:0030449)4.83510247
33protoporphyrinogen IX metabolic process (GO:0046501)4.78180128
34homocysteine metabolic process (GO:0050667)4.75945952
35lysine catabolic process (GO:0006554)4.75660452
36lysine metabolic process (GO:0006553)4.75660452
37mitotic sister chromatid cohesion (GO:0007064)4.72353022
38bile acid metabolic process (GO:0008206)4.69315089
39regulation of triglyceride catabolic process (GO:0010896)4.67132230
40reverse cholesterol transport (GO:0043691)4.57584716
41amino-acid betaine metabolic process (GO:0006577)4.53111840
42iron ion import (GO:0097286)4.50210371
43phospholipid efflux (GO:0033700)4.49176243
44negative regulation of cholesterol transport (GO:0032375)4.45089529
45negative regulation of sterol transport (GO:0032372)4.45089529
46triglyceride homeostasis (GO:0070328)4.41670934
47acylglycerol homeostasis (GO:0055090)4.41670934
48regulation of nucleobase-containing compound transport (GO:0032239)4.40538041
49aromatic amino acid family metabolic process (GO:0009072)4.40168197
50pore complex assembly (GO:0046931)4.39016011
51plasma lipoprotein particle remodeling (GO:0034369)4.36463326
52protein-lipid complex remodeling (GO:0034368)4.36463326
53macromolecular complex remodeling (GO:0034367)4.36463326
54histone H3-K36 demethylation (GO:0070544)4.30907209
55glycine metabolic process (GO:0006544)4.27081894
56alpha-amino acid catabolic process (GO:1901606)4.24496721
57tyrosine metabolic process (GO:0006570)4.23512763
58bile acid and bile salt transport (GO:0015721)4.20535710
59regulation of cholesterol esterification (GO:0010872)4.20219403
60regulation of cholesterol homeostasis (GO:2000188)4.18449058
61plasma lipoprotein particle clearance (GO:0034381)4.15397731
62phospholipid homeostasis (GO:0055091)4.10180104
63dicarboxylic acid biosynthetic process (GO:0043650)4.09114810
64cholesterol efflux (GO:0033344)4.03772135
65cellular glucuronidation (GO:0052695)4.03591214
66glutamate metabolic process (GO:0006536)3.96884191
67serine family amino acid metabolic process (GO:0009069)3.96488907
68plasma lipoprotein particle assembly (GO:0034377)3.96065868
69indolalkylamine metabolic process (GO:0006586)3.95273885
70pre-miRNA processing (GO:0031054)3.95198775
71cellular modified amino acid catabolic process (GO:0042219)3.95153834
72ethanol oxidation (GO:0006069)3.90290562
73imidazole-containing compound metabolic process (GO:0052803)3.90175764
74cellular amino acid catabolic process (GO:0009063)3.89848437
75cellular ketone body metabolic process (GO:0046950)3.83916775
76benzene-containing compound metabolic process (GO:0042537)3.79449089
77drug catabolic process (GO:0042737)3.77681175
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.77577873
79positive regulation of lipid catabolic process (GO:0050996)3.76783390
80amine catabolic process (GO:0009310)3.76213712
81cellular biogenic amine catabolic process (GO:0042402)3.76213712
82fibrinolysis (GO:0042730)3.71917096
83coenzyme catabolic process (GO:0009109)3.70948381
84regulation of bile acid biosynthetic process (GO:0070857)3.68112825
852-oxoglutarate metabolic process (GO:0006103)3.67523638
86complement activation, classical pathway (GO:0006958)3.67108524
87cholesterol homeostasis (GO:0042632)3.66843638
88protein-lipid complex assembly (GO:0065005)3.66241277
89protoporphyrinogen IX biosynthetic process (GO:0006782)3.66223836
90regulation of histone H3-K27 methylation (GO:0061085)3.66191007
91serine family amino acid biosynthetic process (GO:0009070)3.65419620
92sterol homeostasis (GO:0055092)3.63528328
93positive regulation of lipoprotein lipase activity (GO:0051006)3.62351643
94positive regulation of triglyceride lipase activity (GO:0061365)3.62351643
95complement activation (GO:0006956)3.61851194
96mitotic chromosome condensation (GO:0007076)3.55855172
97acetyl-CoA metabolic process (GO:0006084)3.55109765
98arginine metabolic process (GO:0006525)3.54186166
99very-low-density lipoprotein particle assembly (GO:0034379)3.53555670
100lipoprotein metabolic process (GO:0042157)3.53405449
101negative regulation of lipase activity (GO:0060192)3.51553225
102negative regulation of histone methylation (GO:0031061)3.50963797
103glucuronate metabolic process (GO:0019585)3.46111286
104uronic acid metabolic process (GO:0006063)3.46111286
105cytoplasmic mRNA processing body assembly (GO:0033962)3.45686086
106protein activation cascade (GO:0072376)3.45482194
107plasma lipoprotein particle organization (GO:0071827)3.44734528
108regulation of fatty acid beta-oxidation (GO:0031998)3.43767868
109cytolysis (GO:0019835)3.41994743
110low-density lipoprotein particle remodeling (GO:0034374)3.41374392
111organic acid catabolic process (GO:0016054)3.40627327
112carboxylic acid catabolic process (GO:0046395)3.40627327
113DNA unwinding involved in DNA replication (GO:0006268)3.39379568
114intestinal cholesterol absorption (GO:0030299)3.38653991
115urate metabolic process (GO:0046415)3.36881652
116interkinetic nuclear migration (GO:0022027)3.33107593
117carnitine metabolic process (GO:0009437)3.32920193
118embryonic process involved in female pregnancy (GO:0060136)3.26798121
119negative regulation of DNA repair (GO:0045738)3.23051391
120positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.22284169
121monoubiquitinated protein deubiquitination (GO:0035520)3.10697932
122mRNA stabilization (GO:0048255)3.06462982
123RNA stabilization (GO:0043489)3.06462982
124carnitine shuttle (GO:0006853)3.05955005
125erythrocyte development (GO:0048821)2.96951348
126definitive hemopoiesis (GO:0060216)2.96055446
127porphyrin-containing compound biosynthetic process (GO:0006779)2.95060873
128COPII vesicle coating (GO:0048208)2.91628306
129DNA duplex unwinding (GO:0032508)2.88383593
130regulation of histone H3-K9 methylation (GO:0051570)2.83581812
131negative regulation of potassium ion transmembrane transport (GO:1901380)2.81712140
132fatty acid transmembrane transport (GO:1902001)2.81655166
133N-terminal protein amino acid acetylation (GO:0006474)2.81308361
134biotin metabolic process (GO:0006768)2.79623917
135negative regulation of fatty acid biosynthetic process (GO:0045717)2.78615811
136DNA geometric change (GO:0032392)2.73512610
137erythrocyte maturation (GO:0043249)2.70688073
138fatty acid homeostasis (GO:0055089)2.69925409
139DNA topological change (GO:0006265)2.69012719
140regulation of histone H3-K4 methylation (GO:0051569)2.66814807
141carnitine transmembrane transport (GO:1902603)2.64239998
142carnitine transport (GO:0015879)2.63018750
143amino-acid betaine transport (GO:0015838)2.63018750
144mitotic nuclear envelope disassembly (GO:0007077)2.62922600
145histone H3-K4 methylation (GO:0051568)2.61564900
146glucocorticoid receptor signaling pathway (GO:0042921)2.60957779
147NLS-bearing protein import into nucleus (GO:0006607)2.60602028
148positive regulation of protein import into nucleus, translocation (GO:0033160)2.60212329
149histone lysine demethylation (GO:0070076)2.59953929
150membrane disassembly (GO:0030397)2.59428960
151nuclear envelope disassembly (GO:0051081)2.59428960
152regulation of histone methylation (GO:0031060)2.56657426
153skeletal muscle adaptation (GO:0043501)2.55803988
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.55589734
155positive regulation of DNA-templated transcription, initiation (GO:2000144)2.53309218
156protein export from nucleus (GO:0006611)2.52142614
157corticosteroid receptor signaling pathway (GO:0031958)2.50596534
158histone H3-K9 demethylation (GO:0033169)2.48466091
159porphyrin-containing compound metabolic process (GO:0006778)2.48352564
160tetrapyrrole biosynthetic process (GO:0033014)2.46432111
161intestinal absorption (GO:0050892)2.46376286
162bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44143382
163response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.43935970
164DNA conformation change (GO:0071103)2.41945070
165peptidyl-lysine dimethylation (GO:0018027)2.41768732
166negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.41470796
167intestinal epithelial cell development (GO:0060576)2.41166189
168phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.40982876
169quaternary ammonium group transport (GO:0015697)2.40540181
170histone demethylation (GO:0016577)2.40489981
171protein localization to chromosome, centromeric region (GO:0071459)2.40350866
1723-UTR-mediated mRNA stabilization (GO:0070935)2.39563551
173cellular hyperosmotic response (GO:0071474)2.39328259
174histone-serine phosphorylation (GO:0035404)2.38138150
175regulation of mRNA stability (GO:0043488)2.37663846
176positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.37504793
177regulation of translational fidelity (GO:0006450)2.36818012
178oxygen transport (GO:0015671)2.35689650
179protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.35175637
180exogenous drug catabolic process (GO:0042738)2.34583201
181sister chromatid segregation (GO:0000819)2.34213972
182protein-lipid complex subunit organization (GO:0071825)2.33459258
183positive regulation of gluconeogenesis (GO:0045722)2.32543423
184histone H3-K4 trimethylation (GO:0080182)2.31836541
185DNA replication initiation (GO:0006270)2.31536420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51258800
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.48637229
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66219844
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.97247499
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.64787705
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.50494589
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.38014953
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.05782618
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98683649
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.82292205
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.16858730
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81503026
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33712893
14CLOCK_20551151_ChIP-Seq_293T_Human2.24933533
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11468555
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05059103
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4585571
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.97476401
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96026024
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92320420
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85241908
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.83394316
23* CHD1_26751641_Chip-Seq_LNCaP_Human1.78001201
24GATA1_22025678_ChIP-Seq_K562_Human1.76327511
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.69851468
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62308652
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61647874
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48255165
29SCL_19346495_ChIP-Seq_HPC-7_Human1.47749634
30* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46788095
31ZNF263_19887448_ChIP-Seq_K562_Human1.45233531
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42954707
33* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39847756
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37086934
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35912095
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33337667
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.31765111
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.29520384
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27395720
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26033389
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.25410915
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25359629
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.20280639
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19363402
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19330295
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19267972
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18388009
48MYB_26560356_Chip-Seq_TH1_Human1.18228917
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15474733
50GATA4_25053715_ChIP-Seq_YYC3_Human1.15053475
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14977768
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14304969
53TFEB_21752829_ChIP-Seq_HELA_Human1.12148552
54* FOXO3_23340844_ChIP-Seq_DLD1_Human1.12097241
55FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10669014
56KDM5A_27292631_Chip-Seq_BREAST_Human1.10126760
57GATA6_25053715_ChIP-Seq_YYC3_Human1.08005498
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07945636
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07528452
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05810555
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04674706
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03903942
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03332728
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01967814
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01537185
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01489007
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.00590094
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00031176
69CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98586988
70ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97184587
71* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97025392
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96888183
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96888183
74SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96443053
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96088600
76CIITA_25753668_ChIP-Seq_RAJI_Human0.94783058
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94531788
78PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94226381
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93138034
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92490831
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92196269
82GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92081507
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91949676
84BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91786074
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.91724659
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91545621
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91172536
88PU_27001747_Chip-Seq_BMDM_Mouse0.90685051
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89951881
90FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89197635
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88959876
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87431638
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84291639
94RACK7_27058665_Chip-Seq_MCF-7_Human0.83985944
95* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82478866
96* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81929349
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80162392
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80026472
99AR_21909140_ChIP-Seq_LNCAP_Human0.79635038
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79376615
101CDX2_20551321_ChIP-Seq_CACO-2_Human0.78898609
102MYC_22102868_ChIP-Seq_BL_Human0.77729916
103* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76990358
104LXR_22292898_ChIP-Seq_THP-1_Human0.76663744
105GATA1_19941826_ChIP-Seq_K562_Human0.76505754
106ATF3_27146783_Chip-Seq_COLON_Human0.76052211
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75860608
108* TCF7_22412390_ChIP-Seq_EML_Mouse0.73093002
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72593109
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72199124
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72039074
112GATA2_19941826_ChIP-Seq_K562_Human0.71695410
113HTT_18923047_ChIP-ChIP_STHdh_Human0.70941990
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.69318552
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.69318552
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69255241
117* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69237147
118* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68980614
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.67051756
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65723466
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.63589220
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63223489
123EGR1_19374776_ChIP-ChIP_THP-1_Human0.62748704
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61582986
125* CREB1_26743006_Chip-Seq_LNCaP_Human0.61488873
126* GATA3_24758297_ChIP-Seq_MCF-7_Human0.60744672
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60220831
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.59587179
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.59280532
130* RARA_24833708_ChIP-Seq_LIVER_Mouse0.59201822
131* ELK3_25401928_ChIP-Seq_HUVEC_Human0.59120562
132CEBPB_22108803_ChIP-Seq_LS180_Human0.58600127
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.58439541
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58392949
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.58206163
136* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.57031364
137* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.56813724
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56359021
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.55804789
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.55676488
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.55180958
142HIF1A_21447827_ChIP-Seq_MCF-7_Human0.54928669
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.54362886
144* NCOR1_26117541_ChIP-Seq_K562_Human0.53903146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.45936086
2MP0005360_urolithiasis7.07772827
3MP0005085_abnormal_gallbladder_physiolo5.80740432
4MP0005365_abnormal_bile_salt5.61855919
5MP0008057_abnormal_DNA_replication4.92232147
6MP0008875_abnormal_xenobiotic_pharmacok4.45432052
7MP0003252_abnormal_bile_duct3.98223311
8MP0003806_abnormal_nucleotide_metabolis3.49744989
9MP0010329_abnormal_lipoprotein_level3.39807005
10MP0009840_abnormal_foam_cell3.19749701
11MP0002009_preneoplasia3.10737702
12MP0005083_abnormal_biliary_tract2.77309468
13MP0001666_abnormal_nutrient_absorption2.64224847
14MP0003191_abnormal_cellular_cholesterol2.51111303
15MP0003705_abnormal_hypodermis_morpholog2.47121201
16MP0004147_increased_porphyrin_level2.44771955
17MP0005332_abnormal_amino_acid2.36364653
18MP0000609_abnormal_liver_physiology2.19982779
19MP0003111_abnormal_nucleus_morphology2.16717066
20MP0003195_calcinosis2.10689966
21MP0002138_abnormal_hepatobiliary_system1.98051971
22MP0004019_abnormal_vitamin_homeostasis1.94629210
23MP0002118_abnormal_lipid_homeostasis1.93493619
24MP0003693_abnormal_embryo_hatching1.92515446
25MP0002396_abnormal_hematopoietic_system1.85720432
26MP0010094_abnormal_chromosome_stability1.83171135
27MP0004957_abnormal_blastocyst_morpholog1.79941953
28MP0005451_abnormal_body_composition1.76417834
29MP0003890_abnormal_embryonic-extraembry1.74232788
30MP0003941_abnormal_skin_development1.72948075
31MP0003646_muscle_fatigue1.71968362
32MP0010307_abnormal_tumor_latency1.71867874
33MP0005319_abnormal_enzyme/_coenzyme1.71430425
34MP0003868_abnormal_feces_composition1.62324131
35MP0001730_embryonic_growth_arrest1.61327010
36MP0004233_abnormal_muscle_weight1.59484483
37MP0003077_abnormal_cell_cycle1.56050764
38MP0010234_abnormal_vibrissa_follicle1.55162589
39MP0003984_embryonic_growth_retardation1.52817262
40MP0002088_abnormal_embryonic_growth/wei1.52327522
41MP0005409_darkened_coat_color1.49256589
42MP0002254_reproductive_system_inflammat1.45973527
43MP0004145_abnormal_muscle_electrophysio1.45215105
44MP0001672_abnormal_embryogenesis/_devel1.41691202
45MP0005380_embryogenesis_phenotype1.41691202
46MP0002877_abnormal_melanocyte_morpholog1.40299733
47MP0002086_abnormal_extraembryonic_tissu1.37977845
48MP0000350_abnormal_cell_proliferation1.29761991
49MP0005584_abnormal_enzyme/coenzyme_acti1.26736799
50MP0000598_abnormal_liver_morphology1.23383368
51MP0009643_abnormal_urine_homeostasis1.22883908
52MP0001764_abnormal_homeostasis1.22733388
53MP0004808_abnormal_hematopoietic_stem1.21863988
54MP0003300_gastrointestinal_ulcer1.20921497
55MP0001697_abnormal_embryo_size1.20425236
56MP0004036_abnormal_muscle_relaxation1.20285671
57MP0003763_abnormal_thymus_physiology1.18366662
58MP0003656_abnormal_erythrocyte_physiolo1.15938377
59MP0005670_abnormal_white_adipose1.14027780
60MP0010630_abnormal_cardiac_muscle1.13216823
61MP0003221_abnormal_cardiomyocyte_apopto1.12271147
62MP0010368_abnormal_lymphatic_system1.12224509
63MP0004087_abnormal_muscle_fiber1.09971791
64MP0009697_abnormal_copulation1.05602827
65MP0000747_muscle_weakness1.05599651
66MP0005647_abnormal_sex_gland1.05356954
67MP0000383_abnormal_hair_follicle1.04865364
68MP0004197_abnormal_fetal_growth/weight/1.04196749
69MP0004264_abnormal_extraembryonic_tissu1.02406236
70MP0002080_prenatal_lethality1.00529627
71MP0003950_abnormal_plasma_membrane1.00217127
72MP0002006_tumorigenesis1.00057910
73MP0004130_abnormal_muscle_cell0.99499006
74MP0009053_abnormal_anal_canal0.98041365
75MP0003011_delayed_dark_adaptation0.97491581
76MP0001873_stomach_inflammation0.96714513
77MP0005375_adipose_tissue_phenotype0.95282640
78MP0009703_decreased_birth_body0.94984551
79MP0009763_increased_sensitivity_to0.94637584
80MP0004084_abnormal_cardiac_muscle0.94170077
81MP0000604_amyloidosis0.93998973
82MP0002796_impaired_skin_barrier0.92784245
83MP0009764_decreased_sensitivity_to0.88711531
84MP0005187_abnormal_penis_morphology0.87933711
85MP0002084_abnormal_developmental_patter0.86228660
86MP0006138_congestive_heart_failure0.85252592
87MP0002971_abnormal_brown_adipose0.83387458
88MP0005666_abnormal_adipose_tissue0.81204837
89MP0005408_hypopigmentation0.81191830
90MP0005220_abnormal_exocrine_pancreas0.79109184
91MP0008469_abnormal_protein_level0.78116733
92MP0000313_abnormal_cell_death0.77427485
93MP0005621_abnormal_cell_physiology0.76646588
94MP0003186_abnormal_redox_activity0.75970262
95MP0000759_abnormal_skeletal_muscle0.75476219
96MP0009642_abnormal_blood_homeostasis0.75269637
97MP0004381_abnormal_hair_follicle0.74384246
98MP0001545_abnormal_hematopoietic_system0.74249366
99MP0005397_hematopoietic_system_phenotyp0.74249366
100MP0005334_abnormal_fat_pad0.74226407
101MP0002060_abnormal_skin_morphology0.72987939
102MP0002106_abnormal_muscle_physiology0.72507930
103MP0008007_abnormal_cellular_replicative0.72044384
104MP0008058_abnormal_DNA_repair0.71795262
105MP0004185_abnormal_adipocyte_glucose0.71641063
106MP0003453_abnormal_keratinocyte_physiol0.70765057
107MP0005636_abnormal_mineral_homeostasis0.69828751
108MP0002078_abnormal_glucose_homeostasis0.69514600
109MP0002085_abnormal_embryonic_tissue0.69323281
110MP0009765_abnormal_xenobiotic_induced0.67761656
111MP0003943_abnormal_hepatobiliary_system0.67345772
112MP0003045_fibrosis0.67075935
113MP0000703_abnormal_thymus_morphology0.67022928
114MP0002928_abnormal_bile_duct0.66517525
115MP0000579_abnormal_nail_morphology0.65071181
116MP0010352_gastrointestinal_tract_polyps0.64278082
117MP0001756_abnormal_urination0.64166605
118MP0009672_abnormal_birth_weight0.63592688
119MP0004947_skin_inflammation0.61342557
120MP0005464_abnormal_platelet_physiology0.60452997
121MP0005023_abnormal_wound_healing0.60224300
122MP0002166_altered_tumor_susceptibility0.58311063
123MP0005376_homeostasis/metabolism_phenot0.58017522
124MP0002136_abnormal_kidney_physiology0.57758501
125MP0003566_abnormal_cell_adhesion0.57719965
126MP0009384_cardiac_valve_regurgitation0.56136938
127MP0003436_decreased_susceptibility_to0.54667540
128MP0009115_abnormal_fat_cell0.53514468
129MP0001661_extended_life_span0.53245346
130MP0005248_abnormal_Harderian_gland0.52242939
131MP0001915_intracranial_hemorrhage0.51953048
132MP0005076_abnormal_cell_differentiation0.51677861
133MP0000427_abnormal_hair_cycle0.51368101
134MP0005395_other_phenotype0.51149224
135MP0001881_abnormal_mammary_gland0.50415596
136MP0000377_abnormal_hair_follicle0.50195821
137MP0005266_abnormal_metabolism0.49246482
138MP0002168_other_aberrant_phenotype0.48065482
139MP0001243_abnormal_dermal_layer0.47089727
140MP0001216_abnormal_epidermal_layer0.47035667
141MP0010678_abnormal_skin_adnexa0.46223473
142MP0005448_abnormal_energy_balance0.45100457
143MP0005058_abnormal_lysosome_morphology0.43557878
144MP0008961_abnormal_basal_metabolism0.42895172
145MP0005275_abnormal_skin_tensile0.42120476
146MP0006036_abnormal_mitochondrial_physio0.41537621
147MP0005166_decreased_susceptibility_to0.41427834
148MP0002970_abnormal_white_adipose0.40921262
149MP0005501_abnormal_skin_physiology0.40833538
150MP0004782_abnormal_surfactant_physiolog0.40718766
151MP0002098_abnormal_vibrissa_morphology0.40686872
152MP0005084_abnormal_gallbladder_morpholo0.40407144
153MP0003690_abnormal_glial_cell0.38162580
154MP0008873_increased_physiological_sensi0.38139649
155MP0002269_muscular_atrophy0.37847161
156MP0009931_abnormal_skin_appearance0.37578195
157MP0000639_abnormal_adrenal_gland0.36822681

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.09968097
2Intrahepatic cholestasis (HP:0001406)6.80915291
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.25849774
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.09796253
5Xanthomatosis (HP:0000991)6.01203079
6Hypobetalipoproteinemia (HP:0003563)5.91490219
7Prolonged partial thromboplastin time (HP:0003645)5.51212984
8Complement deficiency (HP:0004431)5.40551185
9Hyperlipoproteinemia (HP:0010980)4.94193357
10Hypolipoproteinemia (HP:0010981)4.61086833
11Abnormality of the common coagulation pathway (HP:0010990)4.37978598
12Epidermoid cyst (HP:0200040)4.37185941
13Joint hemorrhage (HP:0005261)4.33324038
14Hyperammonemia (HP:0001987)4.26275875
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.21306208
16Hypoalphalipoproteinemia (HP:0003233)4.16579694
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.08710894
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08058657
19Hyperglycinemia (HP:0002154)4.04423202
20Abnormality of complement system (HP:0005339)4.02527580
21Fat malabsorption (HP:0002630)3.92554014
22Ketosis (HP:0001946)3.90453151
23Hyperglycinuria (HP:0003108)3.79330692
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.66328484
25Abnormality of glycine metabolism (HP:0010895)3.65197344
26Abnormality of serine family amino acid metabolism (HP:0010894)3.65197344
27Hypoglycemic coma (HP:0001325)3.64675967
28Myocardial infarction (HP:0001658)3.61717289
29Abnormality of methionine metabolism (HP:0010901)3.61084128
30Abnormality of the intrinsic pathway (HP:0010989)3.60657761
31Hypercholesterolemia (HP:0003124)3.53597253
32Abnormality of the fingertips (HP:0001211)3.51090546
33Abnormality of pyrimidine metabolism (HP:0004353)3.42218780
34Nemaline bodies (HP:0003798)3.34728462
35Conjugated hyperbilirubinemia (HP:0002908)3.29673071
36Muscle fiber inclusion bodies (HP:0100299)3.27775808
37Hepatocellular carcinoma (HP:0001402)3.15261478
38Dysmetric saccades (HP:0000641)3.13966155
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.13947714
40Exercise-induced myalgia (HP:0003738)3.13456163
41Papillary thyroid carcinoma (HP:0002895)3.09435273
42Abnormality of fatty-acid metabolism (HP:0004359)3.02024985
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00649283
44Abnormality of nucleobase metabolism (HP:0010932)2.97941354
45Hypochromic microcytic anemia (HP:0004840)2.97772118
46Hyperbilirubinemia (HP:0002904)2.89307803
47Hyperkalemia (HP:0002153)2.88946879
48Septate vagina (HP:0001153)2.83233175
49Systemic lupus erythematosus (HP:0002725)2.81222497
50Ketoacidosis (HP:0001993)2.80666897
51Steatorrhea (HP:0002570)2.78789700
52Skin nodule (HP:0200036)2.76955250
53Abnormality of purine metabolism (HP:0004352)2.75802641
54Spontaneous abortion (HP:0005268)2.74835387
55Acanthocytosis (HP:0001927)2.70420442
56Chromsome breakage (HP:0040012)2.69054205
57Spastic diplegia (HP:0001264)2.68347888
58Esophageal varix (HP:0002040)2.68013770
59Neonatal hypoglycemia (HP:0001998)2.65554574
60Acute myeloid leukemia (HP:0004808)2.62863167
61Abnormality of serum amino acid levels (HP:0003112)2.56962336
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56599522
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.52782943
64Mitral stenosis (HP:0001718)2.49457337
65Vascular calcification (HP:0004934)2.45769222
66Glomerulonephritis (HP:0000099)2.44123935
67Malnutrition (HP:0004395)2.43300512
68Gout (HP:0001997)2.43275560
69Subaortic stenosis (HP:0001682)2.42651815
70Abnormality of the left ventricular outflow tract (HP:0011103)2.42651815
71Delayed CNS myelination (HP:0002188)2.40634525
72Cholelithiasis (HP:0001081)2.37272045
73Abnormality of the salivary glands (HP:0010286)2.36921934
74Progressive muscle weakness (HP:0003323)2.36281185
75Recurrent gram-negative bacterial infections (HP:0005420)2.34998818
76Abnormal gallbladder morphology (HP:0012437)2.32526240
77Metabolic acidosis (HP:0001942)2.32316147
78Cardiovascular calcification (HP:0011915)2.25963446
79Paralysis (HP:0003470)2.23237522
80Poikilocytosis (HP:0004447)2.22954463
81Nephroblastoma (Wilms tumor) (HP:0002667)2.22287848
82Hypoglycemic seizures (HP:0002173)2.21779543
83Anal stenosis (HP:0002025)2.21283049
84Lip pit (HP:0100267)2.21081466
85Gingival bleeding (HP:0000225)2.20693636
86Abnormality of nail color (HP:0100643)2.17402622
87Osteomalacia (HP:0002749)2.16975024
88Hemorrhage of the eye (HP:0011885)2.16433700
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.14626455
90Neonatal onset (HP:0003623)2.12375834
91Birth length less than 3rd percentile (HP:0003561)2.10727355
92Thrombophlebitis (HP:0004418)2.10116479
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08080100
94Dicarboxylic aciduria (HP:0003215)2.08080100
95Hyperglycemia (HP:0003074)2.08076992
96Curly hair (HP:0002212)2.07724073
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05508164
98Sensorimotor neuropathy (HP:0007141)2.05468464
99Ankyloglossia (HP:0010296)2.05452358
100Late onset (HP:0003584)2.05289937
101Menorrhagia (HP:0000132)2.02935191
102Thyroid carcinoma (HP:0002890)2.02922155
103Pancreatic islet-cell hyperplasia (HP:0004510)2.02546227
104Flat acetabular roof (HP:0003180)2.01967741
105Cholecystitis (HP:0001082)2.01509648
106Abnormal gallbladder physiology (HP:0012438)2.01509648
107Germ cell neoplasia (HP:0100728)2.01211238
108Abnormality of proline metabolism (HP:0010907)2.01082569
109Hydroxyprolinuria (HP:0003080)2.01082569
110Fair hair (HP:0002286)2.00476850
111Asymmetry of the thorax (HP:0001555)1.99941342
112Gastrointestinal carcinoma (HP:0002672)1.98823238
113Malignant gastrointestinal tract tumors (HP:0006749)1.98823238
114Embryonal renal neoplasm (HP:0011794)1.98473618
115Seborrheic dermatitis (HP:0001051)1.97813908
116Nephritis (HP:0000123)1.94344205
117Amyloidosis (HP:0011034)1.94260300
118Abnormal cartilage morphology (HP:0002763)1.93975223
119Abnormality of reticulocytes (HP:0004312)1.93854324
120Macroorchidism (HP:0000053)1.93441107
121Hepatoblastoma (HP:0002884)1.92028380
122Irritability (HP:0000737)1.90805176
123Pseudobulbar signs (HP:0002200)1.90264467
124Deep philtrum (HP:0002002)1.89462000
125Bowel incontinence (HP:0002607)1.89041374
126Pancreatitis (HP:0001733)1.88895181
127Polycythemia (HP:0001901)1.88774548
128Reticulocytosis (HP:0001923)1.88065803
129Abnormality of the gallbladder (HP:0005264)1.88055613
130Back pain (HP:0003418)1.85946269
131Abnormality of transition element cation homeostasis (HP:0011030)1.85841847
132Sandal gap (HP:0001852)1.85661633
133Long clavicles (HP:0000890)1.84987616
134Sparse lateral eyebrow (HP:0005338)1.84953361
135Progressive external ophthalmoplegia (HP:0000590)1.84297119
136Hyperinsulinemic hypoglycemia (HP:0000825)1.83089359
137Abnormality of the Achilles tendon (HP:0005109)1.83078118
138Lethargy (HP:0001254)1.81031230
139Multiple enchondromatosis (HP:0005701)1.80783947
140Advanced eruption of teeth (HP:0006288)1.80603017
141Abnormal enzyme/coenzyme activity (HP:0012379)1.80410760
142Abnormality of iron homeostasis (HP:0011031)1.79895440
143Increased mean platelet volume (HP:0011877)1.79345837
144Difficulty running (HP:0009046)1.79134746
145Abnormality of the nasal septum (HP:0000419)1.78702941
146Heterotopia (HP:0002282)1.78118715
147Low anterior hairline (HP:0000294)1.77908470
148Right ventricular cardiomyopathy (HP:0011663)1.76216496
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74484038
150Abnormal large intestine physiology (HP:0012700)1.73355116
151Biliary tract neoplasm (HP:0100574)1.73141400
152Exercise-induced muscle cramps (HP:0003710)1.72597863
153Upper motor neuron abnormality (HP:0002127)1.72323124
154Alopecia of scalp (HP:0002293)1.72263802
155Rickets (HP:0002748)1.71813665
156Increased purine levels (HP:0004368)1.71046197
157Hyperuricemia (HP:0002149)1.71046197
158Rectal prolapse (HP:0002035)1.70300976
159Pigmentary retinal degeneration (HP:0001146)1.70262829
160Muscle hypertrophy of the lower extremities (HP:0008968)1.69407913
161Cystic hygroma (HP:0000476)1.69074388
162Subacute progressive viral hepatitis (HP:0006572)1.68893887
163Calf muscle hypertrophy (HP:0008981)1.68081137
164EMG: myopathic abnormalities (HP:0003458)1.66826317
165Coarse hair (HP:0002208)1.66454897
166Long eyelashes (HP:0000527)1.66350663
167Depressed nasal tip (HP:0000437)1.66042277
168Abnormality of homocysteine metabolism (HP:0010919)1.64703504
169Homocystinuria (HP:0002156)1.64703504
170Leiomyosarcoma (HP:0100243)1.62929799
171Uterine leiomyosarcoma (HP:0002891)1.62929799
172Type 1 muscle fiber predominance (HP:0003803)1.62425059
173Increased connective tissue (HP:0009025)1.61613618
174Persistence of primary teeth (HP:0006335)1.59600264
175Cafe-au-lait spot (HP:0000957)1.59549840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.88025698
2BCKDK3.83600258
3SIK13.65323113
4LATS13.44330599
5FGFR43.43428603
6PKN23.16218726
7TRIB33.15891606
8TAOK32.92825470
9OBSCN2.74985451
10SMG12.21436313
11EIF2AK12.14908098
12BRD42.13934563
13PTK62.13688389
14MAP3K102.09999477
15FRK2.01288253
16RIPK11.92414729
17PRPF4B1.91302099
18INSRR1.78377396
19ERBB41.77590102
20TYK21.66753003
21CAMK1D1.65002982
22TTK1.64091000
23MST1R1.58036664
24EEF2K1.55227398
25NEK91.53996133
26CDK121.53957820
27MAPK111.51607782
28TRPM71.48903258
29WNK11.48660305
30CDK61.47825032
31FLT31.45417820
32STK241.44205203
33NLK1.33897815
34MAP3K71.33564282
35MAP2K31.33465122
36STK38L1.31142752
37TTN1.28882886
38STK31.23653778
39MAP3K31.23029570
40TGFBR21.22589990
41JAK21.22355818
42JAK11.22042554
43FGFR31.16638846
44CAMK1G1.12954256
45EPHB11.12057619
46PIK3CG1.10858738
47MAP2K41.10855471
48EPHA31.10454632
49MAP3K131.09215483
50FGFR21.05592076
51PRKAA21.05382450
52CDC71.04608283
53MTOR1.02196370
54BRSK21.00043789
55STK100.95734105
56SGK30.93496166
57ERBB20.91821986
58DMPK0.91067789
59CDK40.90791579
60PIM10.88391025
61KSR20.88130670
62TSSK60.87723936
63PDGFRA0.84038522
64GRK60.83666463
65MKNK20.83359814
66LATS20.83101488
67CHEK10.82862048
68ACVR1B0.81085646
69CDK70.80556332
70RPS6KB10.78320852
71PRKAA10.77004538
72TBK10.74953346
73RIPK40.73373267
74CSF1R0.72634970
75MAP3K20.70783084
76TAF10.70505028
77PTK20.70047492
78ATM0.69761628
79EPHA20.69318967
80RET0.68933228
81DAPK20.68280993
82MET0.66862592
83MAP3K90.65399168
84CLK10.65255310
85YES10.65049583
86MAP4K10.64573392
87LRRK20.63962170
88MAP3K140.63548770
89CSK0.61020492
90PIK3CA0.60816855
91ATR0.59694211
92BMX0.59669301
93MKNK10.59361741
94NUAK10.58318617
95CHEK20.57278782
96GSK3A0.57248263
97ABL20.57219054
98NEK60.57054734
99ALK0.56537914
100TAOK10.56227454
101SGK10.55597217
102FER0.55295989
103DYRK1B0.55228728
104AKT30.55164521
105MARK20.54902459
106CDK20.53592386
107JAK30.53311464
108SGK2230.52150968
109SGK4940.52150968
110SGK20.52087194
111PDK20.50963803
112STK380.50487961
113ICK0.49930386
114CDK10.49618608
115NEK10.49161367
116PBK0.49108484
117MAPK100.48660663
118PASK0.48655090
119KDR0.47928669
120CHUK0.47752632
121SRPK10.47663449
122MAP3K80.47165400
123PNCK0.46882863
124MAP3K60.46492578
125CDK90.44719735
126EIF2AK30.44476710
127KSR10.44078626
128MAPK120.43927869
129SCYL20.43869931
130PDPK10.43490603
131MAPKAPK30.42509818
132FGFR10.42082853
133PDGFRB0.41541227
134MAP2K10.41477653
135TEC0.41164504
136EGFR0.40730485
137MAP3K10.39971856
138PLK40.39835343
139GSK3B0.39674856
140RAF10.38442006
141PDK10.36562443
142PRKACG0.35531499
143PRKCZ0.35407070
144PAK20.34854104
145MAPK40.34750762
146MELK0.34523029
147IGF1R0.33354950
148MAP3K50.32900649
149STK40.31959859
150MAP3K110.31653910
151MAPK70.31222505
152RPS6KB20.30910474
153ZAP700.30684854
154NEK20.30151702

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32528570
2Nitrogen metabolism_Homo sapiens_hsa009103.82183155
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47398650
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40480136
5Arginine biosynthesis_Homo sapiens_hsa002203.13346769
6Complement and coagulation cascades_Homo sapiens_hsa046102.77045932
7Tryptophan metabolism_Homo sapiens_hsa003802.66426324
8Fatty acid degradation_Homo sapiens_hsa000712.58598634
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55314918
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35891516
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32654028
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29401390
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20273254
14Caffeine metabolism_Homo sapiens_hsa002321.98441943
15PPAR signaling pathway_Homo sapiens_hsa033201.96452664
16Butanoate metabolism_Homo sapiens_hsa006501.91428164
17Thyroid cancer_Homo sapiens_hsa052161.89939464
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88175263
19Staphylococcus aureus infection_Homo sapiens_hsa051501.87871090
20Peroxisome_Homo sapiens_hsa041461.87603516
21Propanoate metabolism_Homo sapiens_hsa006401.83864644
22Fatty acid metabolism_Homo sapiens_hsa012121.82854187
23Selenocompound metabolism_Homo sapiens_hsa004501.78191129
24Histidine metabolism_Homo sapiens_hsa003401.75453123
25Chemical carcinogenesis_Homo sapiens_hsa052041.71387978
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.68780018
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68483730
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66771710
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65372728
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.65124722
31beta-Alanine metabolism_Homo sapiens_hsa004101.63318378
32Chronic myeloid leukemia_Homo sapiens_hsa052201.62589133
33Bile secretion_Homo sapiens_hsa049761.58379535
34Retinol metabolism_Homo sapiens_hsa008301.53686290
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53515254
36Prostate cancer_Homo sapiens_hsa052151.47334254
37Phenylalanine metabolism_Homo sapiens_hsa003601.43341363
38Cell cycle_Homo sapiens_hsa041101.42310743
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40332991
40Pancreatic cancer_Homo sapiens_hsa052121.39471442
41ABC transporters_Homo sapiens_hsa020101.35253948
42Fat digestion and absorption_Homo sapiens_hsa049751.34130851
43Lysine degradation_Homo sapiens_hsa003101.31343668
44Endometrial cancer_Homo sapiens_hsa052131.31286256
45mRNA surveillance pathway_Homo sapiens_hsa030151.25300060
46Biosynthesis of amino acids_Homo sapiens_hsa012301.24636675
47Pyruvate metabolism_Homo sapiens_hsa006201.23200018
48Tyrosine metabolism_Homo sapiens_hsa003501.22781480
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.22548455
50Circadian rhythm_Homo sapiens_hsa047101.20360084
51Renal cell carcinoma_Homo sapiens_hsa052111.18410467
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16746190
53MicroRNAs in cancer_Homo sapiens_hsa052061.15647811
54Carbon metabolism_Homo sapiens_hsa012001.14938953
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14891723
56Non-homologous end-joining_Homo sapiens_hsa034501.10904209
57Sulfur metabolism_Homo sapiens_hsa009201.10393191
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07801516
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.04098341
60B cell receptor signaling pathway_Homo sapiens_hsa046621.01227327
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00095500
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00080536
63Folate biosynthesis_Homo sapiens_hsa007900.99025593
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.98377464
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94332683
66Small cell lung cancer_Homo sapiens_hsa052220.93555789
67Prolactin signaling pathway_Homo sapiens_hsa049170.91495655
68Inositol phosphate metabolism_Homo sapiens_hsa005620.88976439
69Vitamin digestion and absorption_Homo sapiens_hsa049770.87201230
70One carbon pool by folate_Homo sapiens_hsa006700.86138917
71Fatty acid elongation_Homo sapiens_hsa000620.85793093
72Arginine and proline metabolism_Homo sapiens_hsa003300.83310994
73RNA transport_Homo sapiens_hsa030130.83036227
74DNA replication_Homo sapiens_hsa030300.80011425
75Vitamin B6 metabolism_Homo sapiens_hsa007500.79407992
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77996845
77Glioma_Homo sapiens_hsa052140.76720421
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76208113
79Glycerolipid metabolism_Homo sapiens_hsa005610.75738097
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75017327
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74686891
82Sulfur relay system_Homo sapiens_hsa041220.72970541
83Steroid biosynthesis_Homo sapiens_hsa001000.72488174
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70203355
85Viral carcinogenesis_Homo sapiens_hsa052030.70047440
86Fatty acid biosynthesis_Homo sapiens_hsa000610.69848924
87Choline metabolism in cancer_Homo sapiens_hsa052310.69841564
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69787528
89HIF-1 signaling pathway_Homo sapiens_hsa040660.67709446
90T cell receptor signaling pathway_Homo sapiens_hsa046600.65779187
91Colorectal cancer_Homo sapiens_hsa052100.65530364
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61434989
93Insulin resistance_Homo sapiens_hsa049310.61119393
94Pentose phosphate pathway_Homo sapiens_hsa000300.60456027
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59563916
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58694257
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.57643603
98ErbB signaling pathway_Homo sapiens_hsa040120.56815410
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56366606
100Hepatitis B_Homo sapiens_hsa051610.55057608
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53460310
102Spliceosome_Homo sapiens_hsa030400.53411482
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49469059
104Glutathione metabolism_Homo sapiens_hsa004800.47578532
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.43526817
106Galactose metabolism_Homo sapiens_hsa000520.37447835
107Fructose and mannose metabolism_Homo sapiens_hsa000510.32781042
108Prion diseases_Homo sapiens_hsa050200.28824553
109Glucagon signaling pathway_Homo sapiens_hsa049220.26792016
110AMPK signaling pathway_Homo sapiens_hsa041520.25446000
111Metabolic pathways_Homo sapiens_hsa011000.25092918
112Insulin signaling pathway_Homo sapiens_hsa049100.15755738
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.15728253
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13782183
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.11486745
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05361471
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03916184
118Bladder cancer_Homo sapiens_hsa052190.03527907
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02814070
120Renin-angiotensin system_Homo sapiens_hsa046140.01665436
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00862049
122mTOR signaling pathway_Homo sapiens_hsa041500.00783120
123Hepatitis C_Homo sapiens_hsa051600.00753873
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.00624606
125Linoleic acid metabolism_Homo sapiens_hsa005910.00265154
126Acute myeloid leukemia_Homo sapiens_hsa05221-0.1010391
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0961213
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0896956
129Non-small cell lung cancer_Homo sapiens_hsa05223-0.0859434
130FoxO signaling pathway_Homo sapiens_hsa04068-0.0814169
131Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0805846
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0696812
133Type II diabetes mellitus_Homo sapiens_hsa04930-0.0393410
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0391530
135Adherens junction_Homo sapiens_hsa04520-0.0138972
136Amoebiasis_Homo sapiens_hsa05146-0.0066077

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