DDIT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.19130949
2central nervous system myelination (GO:0022010)7.19130949
3* ER overload response (GO:0006983)6.43417156
4signal peptide processing (GO:0006465)4.59162443
5protein-cofactor linkage (GO:0018065)4.50881176
6axon ensheathment (GO:0008366)3.80297849
7ensheathment of neurons (GO:0007272)3.80297849
8myelination (GO:0042552)3.79237399
9fatty acid elongation (GO:0030497)3.78301622
10cellular response to glucose starvation (GO:0042149)3.69304711
11import into cell (GO:0098657)3.68300907
12long-chain fatty acid biosynthetic process (GO:0042759)3.66773741
13dopamine biosynthetic process (GO:0042416)3.64315129
14negative regulation of inclusion body assembly (GO:0090084)3.64103526
15negative regulation of neurotransmitter transport (GO:0051589)3.63715424
16respiratory chain complex IV assembly (GO:0008535)3.62547820
17proteasome assembly (GO:0043248)3.61854719
18negative regulation of neurotransmitter secretion (GO:0046929)3.59122025
19negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.52495407
20viral protein processing (GO:0019082)3.52279062
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43877171
22mannosylation (GO:0097502)3.41039964
23nucleotide transmembrane transport (GO:1901679)3.39248761
24amyloid precursor protein metabolic process (GO:0042982)3.38403972
25regulation of retinoic acid receptor signaling pathway (GO:0048385)3.37381519
26response to follicle-stimulating hormone (GO:0032354)3.30052427
27protein prenylation (GO:0018342)3.25753883
28prenylation (GO:0097354)3.25753883
29platelet dense granule organization (GO:0060155)3.22527313
30regulation of cilium movement (GO:0003352)3.21283981
31cerebellar Purkinje cell layer development (GO:0021680)3.18088209
32histamine secretion (GO:0001821)3.17672321
33axoneme assembly (GO:0035082)3.17560141
34neuron remodeling (GO:0016322)3.17429051
35negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.15052443
36mitochondrial respiratory chain complex assembly (GO:0033108)3.12629964
37cytochrome complex assembly (GO:0017004)3.12382177
38positive regulation of action potential (GO:0045760)3.12237116
39GPI anchor biosynthetic process (GO:0006506)3.10605349
40positive regulation of mitochondrial fission (GO:0090141)3.08382332
41oligodendrocyte differentiation (GO:0048709)3.06754741
42photoreceptor cell differentiation (GO:0046530)3.03870796
43eye photoreceptor cell differentiation (GO:0001754)3.03870796
44negative regulation of acute inflammatory response (GO:0002674)3.02227090
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.02126265
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99053988
47oligosaccharide catabolic process (GO:0009313)2.98958572
48cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.94401803
49presynaptic membrane organization (GO:0097090)2.93671171
50cellular response to antibiotic (GO:0071236)2.93383916
51organelle disassembly (GO:1903008)2.92687531
52regulation of B cell apoptotic process (GO:0002902)2.92370054
53protein neddylation (GO:0045116)2.92358092
54protein localization to Golgi apparatus (GO:0034067)2.90445602
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.89464998
56NADH dehydrogenase complex assembly (GO:0010257)2.89464998
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89464998
58ribonucleoprotein complex disassembly (GO:0032988)2.88892014
59transferrin transport (GO:0033572)2.84385390
60amyloid precursor protein catabolic process (GO:0042987)2.82728966
61protein targeting to Golgi (GO:0000042)2.82288247
62protein K11-linked deubiquitination (GO:0035871)2.81140959
63positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.80493972
64mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.80493972
65macroautophagy (GO:0016236)2.78849888
66sequestering of metal ion (GO:0051238)2.77944809
67response to redox state (GO:0051775)2.77935581
68GPI anchor metabolic process (GO:0006505)2.74106556
69sterol biosynthetic process (GO:0016126)2.73120951
70positive regulation of prostaglandin secretion (GO:0032308)2.72123621
71protein complex biogenesis (GO:0070271)2.71843318
72establishment of protein localization to Golgi (GO:0072600)2.70296218
73cholesterol biosynthetic process (GO:0006695)2.69592143
74positive regulation of response to nutrient levels (GO:0032109)2.69039447
75positive regulation of response to extracellular stimulus (GO:0032106)2.69039447
76developmental pigmentation (GO:0048066)2.68579701
77inositol phosphate-mediated signaling (GO:0048016)2.68488712
78peripheral nervous system development (GO:0007422)2.67629487
79trivalent inorganic cation transport (GO:0072512)2.65969655
80ferric iron transport (GO:0015682)2.65969655
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65644102
82water-soluble vitamin biosynthetic process (GO:0042364)2.65408490
83virion attachment to host cell (GO:0019062)2.64388958
84adhesion of symbiont to host cell (GO:0044650)2.64388958
85protein maturation by protein folding (GO:0022417)2.63680987
86myelin maintenance (GO:0043217)2.61660411
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61332360
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.60595554
89negative regulation of chemokine production (GO:0032682)2.59585741
90nonmotile primary cilium assembly (GO:0035058)2.59504855
91energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59417169
92ATP hydrolysis coupled proton transport (GO:0015991)2.59417169
93intra-Golgi vesicle-mediated transport (GO:0006891)2.58791766
94I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.58356367
95regulation of cytokine production involved in inflammatory response (GO:1900015)2.56838019
96glycosylceramide metabolic process (GO:0006677)2.55947246
97regulation of memory T cell differentiation (GO:0043380)2.55857762
98catecholamine biosynthetic process (GO:0042423)2.55583024
99catechol-containing compound biosynthetic process (GO:0009713)2.55583024
100regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53705977
101protein K6-linked ubiquitination (GO:0085020)2.53029889
102iron-sulfur cluster assembly (GO:0016226)2.52221641
103metallo-sulfur cluster assembly (GO:0031163)2.52221641
104protein localization to cilium (GO:0061512)2.50966538
105artery smooth muscle contraction (GO:0014824)2.50491332
106response to testosterone (GO:0033574)2.50301874
107negative regulation of interleukin-1 beta production (GO:0032691)2.49794520
108cellular ketone body metabolic process (GO:0046950)2.49792558
109regulation of collateral sprouting (GO:0048670)2.49089104
110anterograde synaptic vesicle transport (GO:0048490)2.49052031
111magnesium ion transport (GO:0015693)2.49037272
112mitotic cell cycle arrest (GO:0071850)2.48878878
113amino acid import (GO:0043090)2.46880912
114xenobiotic catabolic process (GO:0042178)2.46570221
115diterpenoid biosynthetic process (GO:0016102)2.46245194
116C-terminal protein lipidation (GO:0006501)2.46216443
117isoprenoid biosynthetic process (GO:0008299)2.45799264
118cell wall macromolecule catabolic process (GO:0016998)2.44786626
119L-ascorbic acid metabolic process (GO:0019852)2.44771125
120rRNA methylation (GO:0031167)2.44511073
121substantia nigra development (GO:0021762)2.44044332
122response to lipoprotein particle (GO:0055094)2.43367782
123eosinophil chemotaxis (GO:0048245)2.43301777
124response to methylmercury (GO:0051597)2.42620480
125response to dietary excess (GO:0002021)2.42331069
126positive regulation of oligodendrocyte differentiation (GO:0048714)2.41791683
127negative regulation of interleukin-1 production (GO:0032692)2.41773344
128nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.41738171
129presynaptic membrane assembly (GO:0097105)2.41471273
130endocrine pancreas development (GO:0031018)2.40915830
131positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.39786101
132regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.39786101
133respiratory electron transport chain (GO:0022904)2.39658512
134sulfation (GO:0051923)2.39276038
135negative regulation of JUN kinase activity (GO:0043508)2.38887055
136asymmetric protein localization (GO:0008105)2.37992334
137retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37942475
138preassembly of GPI anchor in ER membrane (GO:0016254)2.37797640
139dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.37662125
140ketone body metabolic process (GO:1902224)2.36945819
141rRNA modification (GO:0000154)2.35977729
142regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.35341715
143toxin metabolic process (GO:0009404)2.35098059
144L-amino acid import (GO:0043092)2.33949857
145tRNA aminoacylation for protein translation (GO:0006418)2.33860784
146positive regulation of p38MAPK cascade (GO:1900745)2.33473298
147mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.33378472
148induction of positive chemotaxis (GO:0050930)2.33372649
149electron transport chain (GO:0022900)2.33268462
150positive regulation of macroautophagy (GO:0016239)2.33240724
151multicellular organism reproduction (GO:0032504)2.32756264
152cellular response to arsenic-containing substance (GO:0071243)2.32001586
153neurotransmitter uptake (GO:0001504)2.31951537
154histamine transport (GO:0051608)2.30934618
155mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.30863931
156cytidine metabolic process (GO:0046087)2.29424432
157cytidine catabolic process (GO:0006216)2.29424432
158cytidine deamination (GO:0009972)2.29424432
159facial nerve structural organization (GO:0021612)2.29400423
160establishment of protein localization to mitochondrial membrane (GO:0090151)2.28799345
161amino acid activation (GO:0043038)2.28573323
162tRNA aminoacylation (GO:0043039)2.28573323
163response to gravity (GO:0009629)2.28449740
164apical protein localization (GO:0045176)2.28113269
165protein palmitoylation (GO:0018345)2.27419049
166positive regulation of megakaryocyte differentiation (GO:0045654)2.27036288
167GDP-mannose metabolic process (GO:0019673)2.26850813
168membrane tubulation (GO:0097320)2.26371551
169regulation of dopamine metabolic process (GO:0042053)2.25960142
170regulation of catecholamine metabolic process (GO:0042069)2.25960142
171response to arsenic-containing substance (GO:0046685)2.25780479
172positive regulation of respiratory burst (GO:0060267)2.24862033
173protein K63-linked deubiquitination (GO:0070536)2.24277660
174keratinocyte development (GO:0003334)2.24211684
175neuron fate determination (GO:0048664)2.24002004
176GMP metabolic process (GO:0046037)2.22966907
177regulation of glucokinase activity (GO:0033131)2.22489283
178regulation of hexokinase activity (GO:1903299)2.22489283
179positive regulation of meiotic cell cycle (GO:0051446)2.22469665
180neuron cell-cell adhesion (GO:0007158)2.22381787
181positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.22319964
182phagosome maturation (GO:0090382)2.22203499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EST1_17652178_ChIP-ChIP_JURKAT_Human3.75696465
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.74116647
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29074624
4* VDR_23849224_ChIP-Seq_CD4+_Human3.08862854
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.03649077
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98703642
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.94089545
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.88953929
9* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.80474197
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79374091
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67494807
12ZNF274_21170338_ChIP-Seq_K562_Hela2.51541611
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46010343
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42562779
15* WT1_19549856_ChIP-ChIP_CCG9911_Human2.36435356
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18989351
17* DCP1A_22483619_ChIP-Seq_HELA_Human2.17620869
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09103513
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02434689
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.02281663
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.00556367
22FOXP3_21729870_ChIP-Seq_TREG_Human1.96308771
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95460035
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87656641
25* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86970467
26GBX2_23144817_ChIP-Seq_PC3_Human1.84219578
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.78846329
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76771090
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75978485
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74215539
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67765926
32VDR_22108803_ChIP-Seq_LS180_Human1.67533226
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67247605
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63902714
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63902714
36TP53_22573176_ChIP-Seq_HFKS_Human1.62147017
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61448999
38* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58538448
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54397097
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.53789571
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.53489104
42GABP_19822575_ChIP-Seq_HepG2_Human1.52391267
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51558525
44* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51354712
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51219536
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.50789120
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49590070
48TTF2_22483619_ChIP-Seq_HELA_Human1.47021675
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44767857
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.44016717
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.43012797
52TAF15_26573619_Chip-Seq_HEK293_Human1.42274873
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.41274556
54MYC_18940864_ChIP-ChIP_HL60_Human1.40588675
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40530039
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39653666
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38865586
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38825266
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37732890
60ER_23166858_ChIP-Seq_MCF-7_Human1.36869162
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36512909
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36231317
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34849903
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34337185
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34318783
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33896291
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33111100
68KDM5A_27292631_Chip-Seq_BREAST_Human1.32238872
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29023607
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.28394781
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25163167
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24769111
73* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23758055
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22867570
75* ATF3_27146783_Chip-Seq_COLON_Human1.21084807
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20986674
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.20280390
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17508339
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17433212
80TP53_18474530_ChIP-ChIP_U2OS_Human1.16777021
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15888555
82STAT1_20625510_ChIP-Seq_HELA_Human1.15493277
83CBP_20019798_ChIP-Seq_JUKART_Human1.14662732
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14662732
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14489748
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14102223
87PHF8_20622853_ChIP-Seq_HELA_Human1.13399574
88* CJUN_26792858_Chip-Seq_BT549_Human1.13192462
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12917253
90* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12275309
91GATA3_26560356_Chip-Seq_TH2_Human1.12202734
92EWS_26573619_Chip-Seq_HEK293_Human1.11201705
93* TFEB_21752829_ChIP-Seq_HELA_Human1.10942757
94FUS_26573619_Chip-Seq_HEK293_Human1.10568848
95GATA1_19941826_ChIP-Seq_K562_Human1.09128886
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08450873
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07876666
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07483065
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06001555
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05616565
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05189316
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05189316
103BCAT_22108803_ChIP-Seq_LS180_Human1.05100750
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04829314
105RBPJ_21746931_ChIP-Seq_IB4_Human1.04572163
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04111316
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03490361
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03196755
109* ELF5_23300383_ChIP-Seq_T47D_Human1.02247808
110CDX2_22108803_ChIP-Seq_LS180_Human1.01819324
111* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01801851
112CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01143878
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99475406
114RNF2_27304074_Chip-Seq_ESCs_Mouse0.99013117
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98915563
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98306583
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.98306583
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.98211268
119HOXB7_26014856_ChIP-Seq_BT474_Human0.95916984
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.95032702
121GATA6_21074721_ChIP-Seq_CACO-2_Human0.94947095
122* SOX2_20726797_ChIP-Seq_SW620_Human0.94698663
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94455932
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92997225
125CLOCK_20551151_ChIP-Seq_293T_Human0.92509301
126EZH2_22144423_ChIP-Seq_EOC_Human0.92352473
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.91965472
128* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91844252
129HNFA_21074721_ChIP-Seq_CACO-2_Human0.91606380
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91345262
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90484783
132ELK1_22589737_ChIP-Seq_MCF10A_Human0.90380083
133AR_20517297_ChIP-Seq_VCAP_Human0.90255886
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89887144
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.89565577
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.89140977
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89027662
138* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88776187
139* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88767705
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88406324
141KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88085760
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87746691
143SRF_21415370_ChIP-Seq_HL-1_Mouse0.87348056
144* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86946129
145IRF8_22096565_ChIP-ChIP_GC-B_Human0.86402375
146* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85882484
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85603952
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.84808135
149* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84388063
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.83986956
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.83517582
152ELK1_19687146_ChIP-ChIP_HELA_Human0.83256040
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83203350
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83162338
155* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82019161
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81992724
157TCF4_22108803_ChIP-Seq_LS180_Human0.81900918
158JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81873722
159* XRN2_22483619_ChIP-Seq_HELA_Human0.81489144
160SOX2_19829295_ChIP-Seq_ESCs_Human0.81233637
161NANOG_19829295_ChIP-Seq_ESCs_Human0.81233637
162IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80814181
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.78437110
164NFYB_21822215_ChIP-Seq_K562_Human0.78072074
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77642233
166FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77011470
167GATA1_26923725_Chip-Seq_HPCs_Mouse0.75637438
168SMAD3_21741376_ChIP-Seq_EPCs_Human0.75414315
169P300_19829295_ChIP-Seq_ESCs_Human0.75041165
170IGF1R_20145208_ChIP-Seq_DFB_Human0.73926278
171EOMES_21245162_ChIP-Seq_HESCs_Human0.72629149
172TAL1_26923725_Chip-Seq_HPCs_Mouse0.72596057
173MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.72168722
174SMC3_22415368_ChIP-Seq_MEFs_Mouse0.71312240
175FLI1_21867929_ChIP-Seq_TH2_Mouse0.68436712
176NR3C1_21868756_ChIP-Seq_MCF10A_Human0.68187672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.27839123
2MP0008438_abnormal_cutaneous_collagen3.05941216
3MP0003136_yellow_coat_color2.97794926
4MP0005171_absent_coat_pigmentation2.74886860
5MP0003186_abnormal_redox_activity2.54215422
6MP0001905_abnormal_dopamine_level2.48083102
7MP0000516_abnormal_urinary_system2.38418449
8MP0005367_renal/urinary_system_phenotyp2.38418449
9MP0000372_irregular_coat_pigmentation2.31557527
10MP0002877_abnormal_melanocyte_morpholog2.27958678
11MP0004742_abnormal_vestibular_system2.18679830
12MP0001529_abnormal_vocalization2.12846106
13MP0009840_abnormal_foam_cell2.12114696
14MP0003724_increased_susceptibility_to2.04316883
15MP0006036_abnormal_mitochondrial_physio2.03968589
16MP0002254_reproductive_system_inflammat2.03285340
17MP0001545_abnormal_hematopoietic_system2.02658220
18MP0005397_hematopoietic_system_phenotyp2.02658220
19MP0001764_abnormal_homeostasis2.01378416
20MP0005623_abnormal_meninges_morphology1.99121333
21MP0003656_abnormal_erythrocyte_physiolo1.97652983
22MP0002295_abnormal_pulmonary_circulatio1.93292635
23MP0001542_abnormal_bone_strength1.89835454
24MP0003634_abnormal_glial_cell1.88108652
25MP0008058_abnormal_DNA_repair1.85219226
26MP0005503_abnormal_tendon_morphology1.76889590
27MP0005410_abnormal_fertilization1.75560327
28MP0004270_analgesia1.71564816
29MP0002272_abnormal_nervous_system1.69516466
30MP0001986_abnormal_taste_sensitivity1.69307394
31MP0004142_abnormal_muscle_tone1.68343373
32MP0002909_abnormal_adrenal_gland1.65624981
33MP0004134_abnormal_chest_morphology1.64504953
34MP0002734_abnormal_mechanical_nocicepti1.63703326
35MP0003279_aneurysm1.62959458
36MP0004147_increased_porphyrin_level1.62598883
37MP0003950_abnormal_plasma_membrane1.61615108
38MP0005409_darkened_coat_color1.60154492
39MP0001348_abnormal_lacrimal_gland1.59410866
40MP0000013_abnormal_adipose_tissue1.58811485
41MP0008875_abnormal_xenobiotic_pharmacok1.58303659
42MP0003690_abnormal_glial_cell1.58141142
43MP0005646_abnormal_pituitary_gland1.55539451
44MP0001501_abnormal_sleep_pattern1.53202972
45MP0001486_abnormal_startle_reflex1.50621467
46MP0005084_abnormal_gallbladder_morpholo1.47097175
47MP0009046_muscle_twitch1.45367145
48MP0002064_seizures1.43385354
49MP0003786_premature_aging1.42422927
50MP0004484_altered_response_of1.40818586
51MP0002148_abnormal_hypersensitivity_rea1.40758498
52MP0004019_abnormal_vitamin_homeostasis1.40492631
53MP0002090_abnormal_vision1.37575369
54MP0002138_abnormal_hepatobiliary_system1.36321239
55MP0002277_abnormal_respiratory_mucosa1.33287041
56MP0005332_abnormal_amino_acid1.33262561
57MP0001502_abnormal_circadian_rhythm1.32292374
58MP0008877_abnormal_DNA_methylation1.31008976
59MP0009785_altered_susceptibility_to1.30836693
60MP0001299_abnormal_eye_distance/1.30571480
61MP0008872_abnormal_physiological_respon1.30010208
62MP0004381_abnormal_hair_follicle1.28797164
63MP0005058_abnormal_lysosome_morphology1.28735500
64MP0001970_abnormal_pain_threshold1.27669742
65MP0003806_abnormal_nucleotide_metabolis1.27643959
66MP0006072_abnormal_retinal_apoptosis1.27573313
67MP0006082_CNS_inflammation1.27366043
68MP0002102_abnormal_ear_morphology1.27184440
69MP0000003_abnormal_adipose_tissue1.27110949
70MP0001188_hyperpigmentation1.26785969
71MP0006276_abnormal_autonomic_nervous1.25407908
72MP0009250_abnormal_appendicular_skeleto1.24069179
73MP0005636_abnormal_mineral_homeostasis1.23652630
74* MP0002229_neurodegeneration1.23482961
75MP0001984_abnormal_olfaction1.22261826
76MP0003122_maternal_imprinting1.21874810
77MP0004885_abnormal_endolymph1.21724130
78* MP0005164_abnormal_response_to1.20766248
79MP0005389_reproductive_system_phenotype1.20431854
80MP0001851_eye_inflammation1.20185913
81MP0001919_abnormal_reproductive_system1.17993246
82MP0010386_abnormal_urinary_bladder1.17983072
83MP0002837_dystrophic_cardiac_calcinosis1.16888329
84MP0002933_joint_inflammation1.16034737
85MP0002160_abnormal_reproductive_system1.14174730
86MP0002132_abnormal_respiratory_system1.14167744
87MP0005083_abnormal_biliary_tract1.13711538
88MP0001756_abnormal_urination1.13384121
89MP0001727_abnormal_embryo_implantation1.11628979
90MP0008007_abnormal_cellular_replicative1.10440121
91MP0003172_abnormal_lysosome_physiology1.08182587
92MP0000343_altered_response_to1.06209824
93MP0005310_abnormal_salivary_gland1.04726186
94MP0005257_abnormal_intraocular_pressure1.04077573
95MP0002876_abnormal_thyroid_physiology1.04070306
96MP0009697_abnormal_copulation1.03631954
97MP0002928_abnormal_bile_duct1.03614484
98MP0005645_abnormal_hypothalamus_physiol1.03124161
99MP0002638_abnormal_pupillary_reflex1.02274897
100MP0003632_abnormal_nervous_system1.02234222
101MP0009764_decreased_sensitivity_to1.02153196
102MP0002095_abnormal_skin_pigmentation1.01997172
103MP0003880_abnormal_central_pattern1.01080315
104MP0000749_muscle_degeneration1.01015851
105MP0000358_abnormal_cell_content/0.99271852
106MP0005408_hypopigmentation0.99055256
107MP0008995_early_reproductive_senescence0.98940107
108MP0005508_abnormal_skeleton_morphology0.98918217
109MP0001958_emphysema0.97539075
110MP0005423_abnormal_somatic_nervous0.97241972
111MP0004808_abnormal_hematopoietic_stem0.96890205
112MP0002163_abnormal_gland_morphology0.95466041
113MP0005551_abnormal_eye_electrophysiolog0.95315534
114MP0002998_abnormal_bone_remodeling0.94607926
115MP0000678_abnormal_parathyroid_gland0.94544944
116MP0004043_abnormal_pH_regulation0.91177537
117MP0005075_abnormal_melanosome_morpholog0.90867567
118MP0005220_abnormal_exocrine_pancreas0.89667920
119MP0002067_abnormal_sensory_capabilities0.88847381
120MP0008873_increased_physiological_sensi0.88609346
121MP0003828_pulmonary_edema0.87721026
122MP0005379_endocrine/exocrine_gland_phen0.87331244
123MP0001929_abnormal_gametogenesis0.86505559
124MP0008569_lethality_at_weaning0.85814187
125MP0003195_calcinosis0.85242918
126MP0006035_abnormal_mitochondrial_morpho0.84698186
127MP0005187_abnormal_penis_morphology0.84238357
128MP0002735_abnormal_chemical_nociception0.83864681
129MP0009643_abnormal_urine_homeostasis0.83671275
130MP0004133_heterotaxia0.82896104
131MP0008469_abnormal_protein_level0.82598379
132MP0002108_abnormal_muscle_morphology0.82163859
133MP0001963_abnormal_hearing_physiology0.81134326
134MP0000778_abnormal_nervous_system0.80758360
135MP0003436_decreased_susceptibility_to0.79907917
136MP0009745_abnormal_behavioral_response0.79879564
137MP0005334_abnormal_fat_pad0.79603484
138MP0005670_abnormal_white_adipose0.79528336
139MP0002557_abnormal_social/conspecific_i0.79088334
140* MP0002882_abnormal_neuron_morphology0.78919992
141MP0000631_abnormal_neuroendocrine_gland0.78394885
142MP0001440_abnormal_grooming_behavior0.78318092
143MP0010307_abnormal_tumor_latency0.77497009
144MP0000747_muscle_weakness0.77122959
145MP0008775_abnormal_heart_ventricle0.77064781
146MP0003959_abnormal_lean_body0.76269363
147MP0000015_abnormal_ear_pigmentation0.76069247
148MP0001944_abnormal_pancreas_morphology0.76048893
149MP0004272_abnormal_basement_membrane0.75744506
150MP0002693_abnormal_pancreas_physiology0.75301316
151MP0009384_cardiac_valve_regurgitation0.75006470
152MP0002752_abnormal_somatic_nervous0.74976400
153MP0003795_abnormal_bone_structure0.74747378
154MP0009278_abnormal_bone_marrow0.74643597
155MP0000653_abnormal_sex_gland0.74580406
156* MP0005376_homeostasis/metabolism_phenot0.74448339
157MP0002733_abnormal_thermal_nociception0.74395692
158MP0002133_abnormal_respiratory_system0.74175712
159MP0005388_respiratory_system_phenotype0.74175712
160MP0005390_skeleton_phenotype0.73953884
161MP0002938_white_spotting0.72932109
162MP0002751_abnormal_autonomic_nervous0.72787562
163MP0003631_nervous_system_phenotype0.72652996
164MP0000371_diluted_coat_color0.72001287

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.67743780
2Hypothermia (HP:0002045)4.30869827
3Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.18056837
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.09730548
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.09730548
6Acute necrotizing encephalopathy (HP:0006965)3.80920868
7Upper limb muscle weakness (HP:0003484)3.56565752
8Peripheral hypomyelination (HP:0007182)3.27044694
9Abnormal mitochondria in muscle tissue (HP:0008316)3.26715885
10Mitochondrial inheritance (HP:0001427)3.21479690
11Progressive macrocephaly (HP:0004481)3.19709883
12Neurofibrillary tangles (HP:0002185)3.08326943
13Tetraparesis (HP:0002273)3.07203247
14Stridor (HP:0010307)3.06265925
15Chronic hepatic failure (HP:0100626)2.98301105
16Atonic seizures (HP:0010819)2.96057013
17Hyperinsulinemic hypoglycemia (HP:0000825)2.93077615
18Increased neuronal autofluorescent lipopigment (HP:0002074)2.86697168
19Vertebral compression fractures (HP:0002953)2.83687219
203-Methylglutaconic aciduria (HP:0003535)2.81985455
21Abnormality of dentin (HP:0010299)2.81671334
22Renal Fanconi syndrome (HP:0001994)2.78355760
23Exocrine pancreatic insufficiency (HP:0001738)2.76387849
24Hepatocellular necrosis (HP:0001404)2.74064975
25Parakeratosis (HP:0001036)2.71098012
26Congenital primary aphakia (HP:0007707)2.69451062
27Patchy hypopigmentation of hair (HP:0011365)2.67965633
28Hypokinesia (HP:0002375)2.61117665
29Pancreatic cysts (HP:0001737)2.60603590
30Cholecystitis (HP:0001082)2.60492151
31Abnormal gallbladder physiology (HP:0012438)2.60492151
32Tongue fasciculations (HP:0001308)2.59304949
33Segmental peripheral demyelination/remyelination (HP:0003481)2.53621918
34Abnormal drinking behavior (HP:0030082)2.52615916
35Polydipsia (HP:0001959)2.52615916
36Gait imbalance (HP:0002141)2.52429667
37Disproportionate short-trunk short stature (HP:0003521)2.51486867
38Exertional dyspnea (HP:0002875)2.49133752
39Abnormality of the pancreatic islet cells (HP:0006476)2.47992728
40Abnormality of endocrine pancreas physiology (HP:0012093)2.47992728
41Ketoacidosis (HP:0001993)2.47747293
42Nephrogenic diabetes insipidus (HP:0009806)2.46547068
43Acute encephalopathy (HP:0006846)2.46296759
44Type I transferrin isoform profile (HP:0003642)2.43146378
45Foot dorsiflexor weakness (HP:0009027)2.42049412
46Neuroendocrine neoplasm (HP:0100634)2.41314108
47Congenital stationary night blindness (HP:0007642)2.38630907
48Albinism (HP:0001022)2.35270258
49Hypomagnesemia (HP:0002917)2.35137026
50Retinal dysplasia (HP:0007973)2.34996418
51Increased cerebral lipofuscin (HP:0011813)2.32799374
52Leukodystrophy (HP:0002415)2.31269826
53Onion bulb formation (HP:0003383)2.30631825
54Pheochromocytoma (HP:0002666)2.29910119
55Abnormal glycosylation (HP:0012345)2.29773356
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29773356
57Abnormal protein N-linked glycosylation (HP:0012347)2.29773356
58Abnormal protein glycosylation (HP:0012346)2.29773356
59Abnormality of the corticospinal tract (HP:0002492)2.28284853
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27924287
61Increased serum lactate (HP:0002151)2.27316956
62Abnormal rod and cone electroretinograms (HP:0008323)2.24800515
63Abnormality of renal resorption (HP:0011038)2.24233021
64Lactic acidosis (HP:0003128)2.23373444
65Abnormality of liposaccharide metabolism (HP:0010968)2.22687498
66Abnormality of glycolipid metabolism (HP:0010969)2.22687498
67Submucous cleft hard palate (HP:0000176)2.22338282
68True hermaphroditism (HP:0010459)2.21681408
69Abnormality of the pons (HP:0007361)2.21197573
70White forelock (HP:0002211)2.19967557
71Congenital sensorineural hearing impairment (HP:0008527)2.19608659
72Limb dystonia (HP:0002451)2.18918558
73Increased CSF lactate (HP:0002490)2.18837937
74Nephronophthisis (HP:0000090)2.18461485
75Abnormality of the foot musculature (HP:0001436)2.18012437
76Failure to thrive in infancy (HP:0001531)2.17324253
77Sensory axonal neuropathy (HP:0003390)2.13056693
78Hypoplasia of the odontoid process (HP:0003311)2.11810163
79Bradycardia (HP:0001662)2.11651125
80Muscle fibrillation (HP:0010546)2.10595964
81Aplasia/hypoplasia of the uterus (HP:0008684)2.08877900
82Type I diabetes mellitus (HP:0100651)2.08532452
83Muscular hypotonia of the trunk (HP:0008936)2.08062728
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06977305
85Median cleft lip (HP:0000161)2.05962214
86Cerebral edema (HP:0002181)2.05889353
87Abnormal tarsal ossification (HP:0008369)2.05462259
88Respiratory failure (HP:0002878)2.04383829
89Optic disc pallor (HP:0000543)2.04334221
90Cerebral inclusion bodies (HP:0100314)2.04104652
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02925445
92Axonal loss (HP:0003447)2.02618504
93Tubular atrophy (HP:0000092)2.02173900
94Abnormality of urine glucose concentration (HP:0011016)2.02031900
95Glycosuria (HP:0003076)2.02031900
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00233562
97Increased hepatocellular lipid droplets (HP:0006565)1.99367518
98Abnormal pupillary function (HP:0007686)1.98668791
99Attenuation of retinal blood vessels (HP:0007843)1.97715781
100Entropion (HP:0000621)1.97406378
101Hypoplasia of the iris (HP:0007676)1.96974630
102Cervical subluxation (HP:0003308)1.96915526
103Tetany (HP:0001281)1.96893994
104Loss of speech (HP:0002371)1.96753179
105Abnormality of DNA repair (HP:0003254)1.96625742
106Abnormal ciliary motility (HP:0012262)1.96371852
107Beaking of vertebral bodies (HP:0004568)1.94798717
108Diaphragmatic weakness (HP:0009113)1.94734721
109Vacuolated lymphocytes (HP:0001922)1.93750617
110Abnormality of the odontoid process (HP:0003310)1.93420377
111Muscle fiber splitting (HP:0003555)1.91068592
112Aplasia/Hypoplasia of the lens (HP:0008063)1.90690568
113Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90590281
114Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90289385
115Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90289385
116Abnormal respiratory motile cilium physiology (HP:0012261)1.90193018
117Autoamputation (HP:0001218)1.89777493
118Hepatic necrosis (HP:0002605)1.89007483
119Hyperthyroidism (HP:0000836)1.88955092
120Short tibia (HP:0005736)1.88138727
121Wormian bones (HP:0002645)1.86358141
122Metaphyseal dysplasia (HP:0100255)1.85790764
123Large for gestational age (HP:0001520)1.84795768
124Exercise intolerance (HP:0003546)1.84506803
125Ectropion (HP:0000656)1.84252182
126Abnormal hair whorl (HP:0010721)1.83984162
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83886638
128Abnormal pancreas size (HP:0012094)1.83665704
129Increased intramyocellular lipid droplets (HP:0012240)1.82926032
130Polyuria (HP:0000103)1.82809405
131Soft skin (HP:0000977)1.82641400
132Hypoplasia of the pons (HP:0012110)1.82294128
133Round ear (HP:0100830)1.81974533
134Degeneration of anterior horn cells (HP:0002398)1.81955642
135Abnormality of the anterior horn cell (HP:0006802)1.81955642
136Ankle clonus (HP:0011448)1.81027479
137Hyperparathyroidism (HP:0000843)1.80470586
138Barrel-shaped chest (HP:0001552)1.80330581
139Abnormality of the renal medulla (HP:0100957)1.78008093
140Progressive neurologic deterioration (HP:0002344)1.77089487
141Cortical visual impairment (HP:0100704)1.75601951
142Anteriorly placed anus (HP:0001545)1.75129138
143Neutropenia (HP:0001875)1.74894563
144Medial flaring of the eyebrow (HP:0010747)1.74722699
145Keratitis (HP:0000491)1.74653099
146Stomach cancer (HP:0012126)1.74202255
147Severe visual impairment (HP:0001141)1.73187090
148Ketosis (HP:0001946)1.73139705
149Squamous cell carcinoma (HP:0002860)1.72601974
150Episodic fever (HP:0001954)1.71907698
151Delayed gross motor development (HP:0002194)1.71570601
152Poor coordination (HP:0002370)1.70678002
153Hypoglycemic coma (HP:0001325)1.70022236
154Stomatitis (HP:0010280)1.69807482
155Abnormality of cells of the erythroid lineage (HP:0012130)1.69369230
156Abnormality of the heme biosynthetic pathway (HP:0010472)1.68796142
157Abnormality of dental color (HP:0011073)1.62807906
158Nonimmune hydrops fetalis (HP:0001790)1.62306782
159Pancreatic fibrosis (HP:0100732)1.61810362
160Abnormality of calcium-phosphate metabolism (HP:0100530)1.60775677
161Lipid accumulation in hepatocytes (HP:0006561)1.58848236
162Hypoplastic pelvis (HP:0008839)1.58371812
163Distal lower limb amyotrophy (HP:0008944)1.57548135
164Infantile muscular hypotonia (HP:0008947)1.56563269
165Dysostosis multiplex (HP:0000943)1.55874708
166Abnormality of midbrain morphology (HP:0002418)1.55870023
167Molar tooth sign on MRI (HP:0002419)1.55870023
168Abnormality of glycosphingolipid metabolism (HP:0004343)1.55009483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK54.82037955
2SIK33.80213301
3MAPK153.64802116
4TRIM282.99777848
5FRK2.95991403
6STK392.90753690
7EPHB12.77683618
8EIF2AK12.67809742
9ERN12.39159460
10MAP2K22.37356114
11PNCK2.25752898
12MST42.25557637
13MAP4K22.20578079
14PDK22.14095321
15PIM22.03923805
16NME12.03316461
17TRPM71.90746374
18BMPR1B1.86484100
19STK161.79552409
20TIE11.78851503
21OXSR11.71777668
22PBK1.70137101
23ADRBK21.67372554
24GRK71.66962805
25EPHA31.56653722
26MUSK1.56136301
27WNK41.51467693
28MAP3K121.49750214
29TNIK1.45445041
30VRK11.43504192
31BRSK21.39080013
32UHMK11.38815089
33RPS6KA51.36456638
34TLK11.32524363
35PKN11.31690682
36TAOK31.21090887
37DAPK31.20843169
38DYRK31.19911764
39STK38L1.18098565
40CAMK2D1.18009805
41MAPKAPK31.16004499
42WEE11.14247289
43NUAK11.13539717
44HIPK21.12265600
45TBK11.11970501
46WNK31.10157202
47CSNK1G31.06328448
48ABL21.03392685
49IKBKB1.03373486
50CHUK1.03160024
51IRAK41.03028678
52CDK191.02506734
53CSNK1G11.02167470
54IRAK31.01445826
55PLK21.01267778
56IKBKE1.00347884
57MARK30.98092466
58CAMK2B0.96814136
59BCKDK0.95868413
60PAK30.94536441
61PRPF4B0.93080778
62IRAK10.92908767
63SCYL20.91404002
64NLK0.91292841
65CASK0.88322366
66WNK10.87943097
67INSRR0.87692511
68ERBB30.86746922
69PRKD30.86490536
70MAP3K20.86250858
71BMX0.85744779
72CSNK1A1L0.85467179
73RPS6KA20.85452286
74LMTK20.81194921
75CDK30.79396170
76CDK80.78132930
77KIT0.77909788
78ROCK20.77212137
79EPHA20.77036709
80CAMKK20.76968386
81SGK4940.76289814
82SGK2230.76289814
83MYLK0.75777949
84MET0.75763695
85CAMK1D0.75761112
86DYRK20.75626687
87PHKG10.75385860
88MAP3K50.74747559
89BCR0.73832929
90PAK20.73657774
91PINK10.73252519
92TSSK60.69810826
93PRKCE0.68542436
94EPHB20.67252820
95GRK50.66567564
96IRAK20.64701760
97PTK2B0.63573925
98NME20.63374721
99MAPK130.62746352
100EIF2AK30.62285538
101DYRK1A0.61969447
102EIF2AK20.59971131
103TXK0.59956615
104PRKG20.59259757
105GRK10.58435058
106CCNB10.58193486
107ARAF0.57666818
108NEK60.57549772
109MOS0.55854893
110CAMK2A0.54498684
111MAP3K140.54330288
112NTRK30.52961298
113TEC0.52686145
114DDR20.51444495
115FER0.50586601
116LIMK10.50369391
117PLK30.50262794
118MAP3K30.49581180
119GSK3A0.49372879
120PRKD10.49322031
121CAMK2G0.47792278
122MAP2K10.47716812
123CAMK1G0.47693532
124PIM10.45976478
125NTRK10.45529028
126TNK20.45372724
127STK380.44922091
128ERBB40.44383329
129MARK20.43940512
130CSNK1G20.43472949
131MAPK70.43123347
132PRKD20.42968844
133KSR10.42218976
134ABL10.41414388
135BMPR20.41235373
136DMPK0.40774148
137PRKCI0.38892470
138AKT30.38881805
139YES10.37689622
140BRD40.34708047
141CDK50.34701070
142ADRBK10.34270531
143PHKG20.33703695
144PRKAA10.33148867
145RPS6KA10.31511544
146PRKAA20.30045152
147STK30.28261239
148PRKCG0.27202186
149* CSNK2A10.27075830

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.56211397
2Oxidative phosphorylation_Homo sapiens_hsa001903.42643493
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87944971
4Parkinsons disease_Homo sapiens_hsa050122.66292336
5Circadian rhythm_Homo sapiens_hsa047102.56538278
6Collecting duct acid secretion_Homo sapiens_hsa049662.53235915
7Vibrio cholerae infection_Homo sapiens_hsa051102.47295790
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32027958
9Rheumatoid arthritis_Homo sapiens_hsa053232.16521143
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13343335
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.08197801
12Alzheimers disease_Homo sapiens_hsa050102.04111101
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01111670
14Sphingolipid metabolism_Homo sapiens_hsa006001.99093235
15Steroid biosynthesis_Homo sapiens_hsa001001.96956330
16* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79184270
17Fatty acid elongation_Homo sapiens_hsa000621.77781412
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77683999
19* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76796760
20Huntingtons disease_Homo sapiens_hsa050161.76689787
21Legionellosis_Homo sapiens_hsa051341.75739179
22Other glycan degradation_Homo sapiens_hsa005111.71314037
23Ether lipid metabolism_Homo sapiens_hsa005651.67611546
24Phagosome_Homo sapiens_hsa041451.53749929
25Nitrogen metabolism_Homo sapiens_hsa009101.52602737
26Cocaine addiction_Homo sapiens_hsa050301.43858314
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41861517
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41740106
29Selenocompound metabolism_Homo sapiens_hsa004501.41074487
30Sulfur metabolism_Homo sapiens_hsa009201.40615905
31Lysosome_Homo sapiens_hsa041421.37651417
32RNA degradation_Homo sapiens_hsa030181.36309409
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35757676
34Serotonergic synapse_Homo sapiens_hsa047261.34650338
35Synaptic vesicle cycle_Homo sapiens_hsa047211.34162899
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32663577
37Fanconi anemia pathway_Homo sapiens_hsa034601.32484171
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21176844
39Fructose and mannose metabolism_Homo sapiens_hsa000511.17917927
40Butanoate metabolism_Homo sapiens_hsa006501.17754817
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.14872399
42One carbon pool by folate_Homo sapiens_hsa006701.13593327
43Ribosome_Homo sapiens_hsa030101.12221259
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08567998
45Glutathione metabolism_Homo sapiens_hsa004801.07952026
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01370046
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99958144
48RNA transport_Homo sapiens_hsa030130.98903544
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98638274
50Vitamin B6 metabolism_Homo sapiens_hsa007500.96773727
51Cardiac muscle contraction_Homo sapiens_hsa042600.96186774
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94594296
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94167172
54Homologous recombination_Homo sapiens_hsa034400.92221994
55ECM-receptor interaction_Homo sapiens_hsa045120.91876131
56Linoleic acid metabolism_Homo sapiens_hsa005910.90237187
57Folate biosynthesis_Homo sapiens_hsa007900.89975219
58p53 signaling pathway_Homo sapiens_hsa041150.88369949
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87862641
60Arachidonic acid metabolism_Homo sapiens_hsa005900.87738062
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86000887
62Malaria_Homo sapiens_hsa051440.85688101
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84153155
64Spliceosome_Homo sapiens_hsa030400.82028125
65Alcoholism_Homo sapiens_hsa050340.81626006
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81413687
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.79848310
68Caffeine metabolism_Homo sapiens_hsa002320.78784597
69Insulin secretion_Homo sapiens_hsa049110.77984093
70GABAergic synapse_Homo sapiens_hsa047270.76702408
71Amphetamine addiction_Homo sapiens_hsa050310.75937633
72Histidine metabolism_Homo sapiens_hsa003400.75377732
73Dorso-ventral axis formation_Homo sapiens_hsa043200.74829201
74Prion diseases_Homo sapiens_hsa050200.74633810
75Phototransduction_Homo sapiens_hsa047440.74401545
76RNA polymerase_Homo sapiens_hsa030200.74247593
77TNF signaling pathway_Homo sapiens_hsa046680.73210545
78Morphine addiction_Homo sapiens_hsa050320.73006661
79Taste transduction_Homo sapiens_hsa047420.69342919
80N-Glycan biosynthesis_Homo sapiens_hsa005100.68346222
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66649159
82Olfactory transduction_Homo sapiens_hsa047400.66428558
83Propanoate metabolism_Homo sapiens_hsa006400.66069930
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65355936
85Dopaminergic synapse_Homo sapiens_hsa047280.64874927
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64109111
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63943554
88Cholinergic synapse_Homo sapiens_hsa047250.63551783
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63328466
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62622379
91Proteasome_Homo sapiens_hsa030500.62439211
92Basal transcription factors_Homo sapiens_hsa030220.61999683
93Peroxisome_Homo sapiens_hsa041460.61469053
94Pyrimidine metabolism_Homo sapiens_hsa002400.60901118
95Purine metabolism_Homo sapiens_hsa002300.58155884
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57493260
97Hematopoietic cell lineage_Homo sapiens_hsa046400.57001237
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55554169
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.54585056
100Circadian entrainment_Homo sapiens_hsa047130.53445331
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53146340
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.52371193
103Ras signaling pathway_Homo sapiens_hsa040140.52246116
104Regulation of autophagy_Homo sapiens_hsa041400.52097051
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.51822177
106Axon guidance_Homo sapiens_hsa043600.51786087
107Antigen processing and presentation_Homo sapiens_hsa046120.49624964
108Thyroid hormone synthesis_Homo sapiens_hsa049180.49603637
109Chemical carcinogenesis_Homo sapiens_hsa052040.47970869
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47958321
111HIF-1 signaling pathway_Homo sapiens_hsa040660.47265448
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45959812
113Arginine and proline metabolism_Homo sapiens_hsa003300.45273818
114Measles_Homo sapiens_hsa051620.44290452
115Autoimmune thyroid disease_Homo sapiens_hsa053200.43793422
116* MAPK signaling pathway_Homo sapiens_hsa040100.43743528
117Prostate cancer_Homo sapiens_hsa052150.43707467
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.42830824
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.42416898
120Nucleotide excision repair_Homo sapiens_hsa034200.42411963
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41917299
122Endocytosis_Homo sapiens_hsa041440.41849359
123Salmonella infection_Homo sapiens_hsa051320.41724988
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41028403
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.40613519
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.40326254
127Asthma_Homo sapiens_hsa053100.38619004
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37194341
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33511138
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33307115
131Bladder cancer_Homo sapiens_hsa052190.32187944
132Renal cell carcinoma_Homo sapiens_hsa052110.31727882
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31643079
134Metabolic pathways_Homo sapiens_hsa011000.31512265
135Mineral absorption_Homo sapiens_hsa049780.31023512
136Estrogen signaling pathway_Homo sapiens_hsa049150.30849242
137Glutamatergic synapse_Homo sapiens_hsa047240.28970124
138Osteoclast differentiation_Homo sapiens_hsa043800.28929248
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27752269
140Dilated cardiomyopathy_Homo sapiens_hsa054140.27227296
141Type I diabetes mellitus_Homo sapiens_hsa049400.27055511
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.26698492
143Long-term depression_Homo sapiens_hsa047300.25178008
144Tuberculosis_Homo sapiens_hsa051520.25127438
145Herpes simplex infection_Homo sapiens_hsa051680.24787967
146Melanoma_Homo sapiens_hsa052180.24765231
147Pertussis_Homo sapiens_hsa051330.24363572
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.24012379
149Protein digestion and absorption_Homo sapiens_hsa049740.23352040
150African trypanosomiasis_Homo sapiens_hsa051430.22875300
151FoxO signaling pathway_Homo sapiens_hsa040680.22752804
152Influenza A_Homo sapiens_hsa051640.22026041

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