DDIT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycolytic process (GO:0006096)5.02605930
2desmosome organization (GO:0002934)4.86905012
3glucose 6-phosphate metabolic process (GO:0051156)4.82863819
4positive regulation of p38MAPK cascade (GO:1900745)4.50687684
5regulation of hippo signaling (GO:0035330)4.22796788
6apoptotic process involved in morphogenesis (GO:0060561)4.22518268
7polarized epithelial cell differentiation (GO:0030859)4.22073894
8negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.21219239
9response to muramyl dipeptide (GO:0032495)4.14160208
10endothelial cell chemotaxis (GO:0035767)4.10446378
11regulation of translational fidelity (GO:0006450)4.09852900
12activation of MAPKKK activity (GO:0000185)4.07914254
13establishment of apical/basal cell polarity (GO:0035089)4.04074079
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02623330
15pre-miRNA processing (GO:0031054)3.96828781
16L-serine metabolic process (GO:0006563)3.86641440
17regulation of gene silencing by RNA (GO:0060966)3.79914562
18regulation of posttranscriptional gene silencing (GO:0060147)3.79914562
19regulation of gene silencing by miRNA (GO:0060964)3.79914562
20surfactant homeostasis (GO:0043129)3.70912404
21heterochromatin organization (GO:0070828)3.63993309
22regulation of p38MAPK cascade (GO:1900744)3.61942603
23negative regulation of interleukin-2 production (GO:0032703)3.61530072
24positive regulation of histone deacetylation (GO:0031065)3.60395406
25retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57550526
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52227122
27paraxial mesoderm development (GO:0048339)3.49324161
28establishment or maintenance of monopolar cell polarity (GO:0061339)3.49108575
29establishment of monopolar cell polarity (GO:0061162)3.49108575
30keratinization (GO:0031424)3.45624475
31protein hydroxylation (GO:0018126)3.45119122
32peptidyl-lysine dimethylation (GO:0018027)3.44769082
33coronary vasculature morphogenesis (GO:0060977)3.41452345
34peptidyl-proline hydroxylation (GO:0019511)3.39950660
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38284125
36positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.36800465
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.31545278
38protein retention in ER lumen (GO:0006621)3.27982196
39apoptotic process involved in development (GO:1902742)3.25677748
40regulation of endothelial cell chemotaxis (GO:2001026)3.23509283
41adherens junction assembly (GO:0034333)3.20688282
42ER overload response (GO:0006983)3.20302852
43endoplasmic reticulum unfolded protein response (GO:0030968)3.18539986
44pyruvate metabolic process (GO:0006090)3.15787745
45hippo signaling (GO:0035329)3.14532909
46lung vasculature development (GO:0060426)3.12500374
47intracellular estrogen receptor signaling pathway (GO:0030520)3.11997727
48ER-nucleus signaling pathway (GO:0006984)3.11446120
49homocysteine metabolic process (GO:0050667)3.09239613
50mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.08891063
51positive regulation of SMAD protein import into nucleus (GO:0060391)3.06987475
52cellular response to unfolded protein (GO:0034620)3.06524726
53positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.06510423
544-hydroxyproline metabolic process (GO:0019471)3.05832270
55tolerance induction (GO:0002507)3.05629892
56GDP-mannose metabolic process (GO:0019673)3.03702860
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.01999598
58hemidesmosome assembly (GO:0031581)3.01095672
59atrioventricular valve morphogenesis (GO:0003181)2.99756469
60regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.99728104
61negative regulation of fatty acid transport (GO:2000192)2.94677747
62negative regulation of cell size (GO:0045792)2.93869542
63cell-substrate junction assembly (GO:0007044)2.93630889
64trophectodermal cell differentiation (GO:0001829)2.92751706
65maternal placenta development (GO:0001893)2.92415994
66response to laminar fluid shear stress (GO:0034616)2.91210989
67nodal signaling pathway (GO:0038092)2.91164288
68cellular response to topologically incorrect protein (GO:0035967)2.90756301
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89495647
70negative regulation of histone methylation (GO:0031061)2.89030971
71regulation of translational termination (GO:0006449)2.88175765
72entrainment of circadian clock by photoperiod (GO:0043153)2.88037530
73proline biosynthetic process (GO:0006561)2.86708824
74mitotic G1 DNA damage checkpoint (GO:0031571)2.86677277
75focal adhesion assembly (GO:0048041)2.86127579
76cell-substrate adherens junction assembly (GO:0007045)2.86127579
77mitotic nuclear envelope reassembly (GO:0007084)2.86096018
78nuclear envelope reassembly (GO:0031468)2.86096018
79histone H2A monoubiquitination (GO:0035518)2.83462041
80NLS-bearing protein import into nucleus (GO:0006607)2.82377683
81negative regulation of fatty acid biosynthetic process (GO:0045717)2.82303478
82regulation of SMAD protein import into nucleus (GO:0060390)2.80894423
83peptidyl-arginine omega-N-methylation (GO:0035247)2.80028581
84lung-associated mesenchyme development (GO:0060484)2.79797613
85epithelial cell-cell adhesion (GO:0090136)2.79563007
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78807464
87establishment of skin barrier (GO:0061436)2.78055556
88positive regulation of vascular permeability (GO:0043117)2.77003316
89gluconeogenesis (GO:0006094)2.76348447
90mitochondrial DNA metabolic process (GO:0032042)2.74353909
91regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.72682615
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.71775945
93positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.71775945
94sexual reproduction (GO:0019953)2.71707491
95establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.70473591
963-UTR-mediated mRNA stabilization (GO:0070935)2.70158637
97cellular response to interleukin-4 (GO:0071353)2.69828860
98labyrinthine layer blood vessel development (GO:0060716)2.69705262
99regulation of cholesterol biosynthetic process (GO:0045540)2.69445239
100mRNA stabilization (GO:0048255)2.67291925
101RNA stabilization (GO:0043489)2.67291925
102positive regulation of keratinocyte differentiation (GO:0045618)2.67236537
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66896204
104cytoplasmic sequestering of transcription factor (GO:0042994)2.65424996
105regulation of vitamin D biosynthetic process (GO:0060556)2.64481879
106regulation of sister chromatid cohesion (GO:0007063)2.63243800
107protein localization to endosome (GO:0036010)2.60882463
108folic acid-containing compound biosynthetic process (GO:0009396)2.59857098
109regulation of apoptotic process involved in morphogenesis (GO:1902337)2.59462962
110glial cell proliferation (GO:0014009)2.58998057
111protoporphyrinogen IX metabolic process (GO:0046501)2.57372994
112nuclear pore organization (GO:0006999)2.57162057
113developmental programmed cell death (GO:0010623)2.56698408
114ectodermal placode formation (GO:0060788)2.56602935
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55775018
116anterior/posterior axis specification, embryo (GO:0008595)2.55716699
117cell migration involved in sprouting angiogenesis (GO:0002042)2.55554154
118hexose biosynthetic process (GO:0019319)2.55362388
119dosage compensation (GO:0007549)2.55277174
120mitotic G1/S transition checkpoint (GO:0044819)2.55160496
121intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.54737249
122embryonic process involved in female pregnancy (GO:0060136)2.54554137
123peptidyl-arginine methylation (GO:0018216)2.54333903
124peptidyl-arginine N-methylation (GO:0035246)2.54333903
125regulation of nuclease activity (GO:0032069)2.54177039
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53335912
127regulation of water loss via skin (GO:0033561)2.52666364
128positive regulation of transcription regulatory region DNA binding (GO:2000679)2.51430785
129positive regulation of mitochondrial fission (GO:0090141)2.50622084
130monosaccharide biosynthetic process (GO:0046364)2.49406734
131positive regulation of nuclease activity (GO:0032075)2.49218538
132establishment or maintenance of bipolar cell polarity (GO:0061245)2.49035620
133establishment or maintenance of apical/basal cell polarity (GO:0035088)2.49035620
134regulation of RNA export from nucleus (GO:0046831)2.48892473
135positive regulation of protein kinase C signaling (GO:0090037)2.48208073
136carbohydrate phosphorylation (GO:0046835)2.47963145
137nuclear pore complex assembly (GO:0051292)2.47156829
138chromatin assembly (GO:0031497)2.46673052
139positive regulation of epidermis development (GO:0045684)2.44869642
140spliceosomal tri-snRNP complex assembly (GO:0000244)2.44553223
141negative regulation of catenin import into nucleus (GO:0035414)2.44437204
142serine transport (GO:0032329)2.43647322
143regulation of early endosome to late endosome transport (GO:2000641)2.43281957
144Golgi transport vesicle coating (GO:0048200)2.43069618
145COPI coating of Golgi vesicle (GO:0048205)2.43069618
146response to endoplasmic reticulum stress (GO:0034976)2.42880415
147endothelial tube morphogenesis (GO:0061154)2.42642083
148morphogenesis of an endothelium (GO:0003159)2.42642083
149regulation of cholesterol homeostasis (GO:2000188)2.42425567
150keratinocyte differentiation (GO:0030216)2.42206443
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42002160
152protein heterotrimerization (GO:0070208)2.41571945
153regulation of cardioblast proliferation (GO:0003264)2.41546349
154regulation of secondary heart field cardioblast proliferation (GO:0003266)2.41546349
155embryonic foregut morphogenesis (GO:0048617)2.41135646
156negative regulation of erythrocyte differentiation (GO:0045647)2.41095921
157regulation of interleukin-2 production (GO:0032663)2.40271251
158serine family amino acid biosynthetic process (GO:0009070)2.39718013
159glucocorticoid receptor signaling pathway (GO:0042921)2.39692689
160regulation of anoikis (GO:2000209)2.39585353
161positive regulation of protein deacetylation (GO:0090312)2.39560309
162cell migration involved in gastrulation (GO:0042074)2.38648273
163myelin maintenance (GO:0043217)2.38063317
164regulation of tight junction assembly (GO:2000810)2.37693193
165decidualization (GO:0046697)2.37634585
166regulation of integrin activation (GO:0033623)2.36031424
167mammary gland alveolus development (GO:0060749)2.35481336
168photoperiodism (GO:0009648)2.35372480
169modulation by symbiont of host cellular process (GO:0044068)2.35314389
170cytoplasmic mRNA processing body assembly (GO:0033962)2.34450020
171cell migration in hindbrain (GO:0021535)2.34265755
172negative regulation of bone resorption (GO:0045779)2.34162490
173protein localization to kinetochore (GO:0034501)2.34146806
174germinal center formation (GO:0002467)2.33891084
175gastrulation with mouth forming second (GO:0001702)2.33471149
176placenta blood vessel development (GO:0060674)2.31266883
177histone H3-K9 demethylation (GO:0033169)2.30267376
178anatomical structure regression (GO:0060033)2.29494302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55774264
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.38511103
3* MYC_22102868_ChIP-Seq_BL_Human3.13714993
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.03674153
5* TP63_17297297_ChIP-ChIP_HaCaT_Human2.94544560
6ZNF263_19887448_ChIP-Seq_K562_Human2.71736055
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.60236984
8* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.42507749
9* KDM2B_26808549_Chip-Seq_DND41_Human2.37892749
10E2F7_22180533_ChIP-Seq_HELA_Human2.30289363
11* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23380522
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22530837
13* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17609181
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11868745
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10042476
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09334230
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.07219693
18* CLOCK_20551151_ChIP-Seq_293T_Human2.07201174
19* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.06659990
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06326603
21* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.06230659
22TCF7_22412390_ChIP-Seq_EML_Mouse2.04126604
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98205468
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97664045
25VDR_21846776_ChIP-Seq_THP-1_Human1.96920979
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95143396
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90189032
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89012356
29* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88531042
30* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85072715
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.84823797
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84376105
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82221951
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81506459
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81506459
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81506459
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79001679
38LXR_22292898_ChIP-Seq_THP-1_Human1.76247986
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75054577
40* ATF3_27146783_Chip-Seq_COLON_Human1.74500699
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72003784
42* KDM2B_26808549_Chip-Seq_JURKAT_Human1.69307247
43* KDM2B_26808549_Chip-Seq_K562_Human1.68886485
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67810368
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64308201
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55541745
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55018736
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54888768
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50172700
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48782642
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48134634
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48067835
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47695890
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47393987
55* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46359022
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46321231
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45822479
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.45160559
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45016998
60* MAF_26560356_Chip-Seq_TH2_Human1.44965087
61* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42820706
62* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40926090
63* CREB1_26743006_Chip-Seq_LNCaP_Human1.39763157
64* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39505384
65* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39437599
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38924995
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37884204
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36322541
69* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32795459
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32377265
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31700265
72* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31167191
73NCOR1_26117541_ChIP-Seq_K562_Human1.29641764
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29080084
75* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28535191
76* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28329835
77* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27654124
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.27619234
79UTX_26944678_Chip-Seq_JUKART_Human1.27481177
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27451115
81* MAF_26560356_Chip-Seq_TH1_Human1.25823095
82* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25456505
83* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24958027
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24538050
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23747443
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.23137408
87SMC4_20622854_ChIP-Seq_HELA_Human1.22573081
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.22124504
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22097656
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22037106
91CHD1_26751641_Chip-Seq_LNCaP_Human1.21846352
92* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21196563
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20787094
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19140399
95TP53_22127205_ChIP-Seq_IMR90_Human1.18698905
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18217674
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18195332
98* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17288857
99* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17115246
100* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17115246
101* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17028830
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16487176
103* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16202108
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.14203336
105* GATA1_19941826_ChIP-Seq_K562_Human1.13681185
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.13299046
107P68_20966046_ChIP-Seq_HELA_Human1.09039176
108* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07658815
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07601982
110* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07261772
111* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07103266
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.04158061
113DCP1A_22483619_ChIP-Seq_HELA_Human1.03955157
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03598938
115TET1_21451524_ChIP-Seq_MESCs_Mouse1.03152922
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02838454
117BCOR_27268052_Chip-Seq_Bcells_Human1.01567086
118* GATA6_25053715_ChIP-Seq_YYC3_Human1.00789505
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00691448
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98477753
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.96610082
122* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96497998
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95803034
124BCL6_27268052_Chip-Seq_Bcells_Human0.95687608
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95314850
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95286380
127* XRN2_22483619_ChIP-Seq_HELA_Human0.94605297
128* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94582178
129CIITA_25753668_ChIP-Seq_RAJI_Human0.94424788
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.93807362
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92778560
132* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90043143
133* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89858688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.01642034
2MP0005083_abnormal_biliary_tract3.64164999
3MP0000579_abnormal_nail_morphology3.57938222
4MP0010234_abnormal_vibrissa_follicle3.47113344
5MP0002009_preneoplasia3.16142980
6MP0010352_gastrointestinal_tract_polyps3.10940900
7MP0002653_abnormal_ependyma_morphology3.06525278
8MP0005076_abnormal_cell_differentiation2.98268738
9MP0003656_abnormal_erythrocyte_physiolo2.77069277
10MP0004947_skin_inflammation2.50458495
11MP0005451_abnormal_body_composition2.41932519
12MP0001849_ear_inflammation2.39786059
13MP0005623_abnormal_meninges_morphology2.36213017
14MP0000537_abnormal_urethra_morphology2.35517659
15MP0003566_abnormal_cell_adhesion2.21475559
16MP0003436_decreased_susceptibility_to2.12809953
17MP0001216_abnormal_epidermal_layer2.02489866
18MP0004233_abnormal_muscle_weight2.01749659
19MP0010030_abnormal_orbit_morphology2.01334436
20MP0004858_abnormal_nervous_system1.99599793
21MP0000678_abnormal_parathyroid_gland1.97873927
22MP0004084_abnormal_cardiac_muscle1.87097287
23MP0003300_gastrointestinal_ulcer1.85805849
24MP0000733_abnormal_muscle_development1.82108156
25MP0008961_abnormal_basal_metabolism1.79491683
26MP0002877_abnormal_melanocyte_morpholog1.78957471
27MP0009278_abnormal_bone_marrow1.76022750
28MP0000858_altered_metastatic_potential1.74352370
29MP0003283_abnormal_digestive_organ1.72688162
30MP0002084_abnormal_developmental_patter1.72249693
31MP0008260_abnormal_autophagy1.71412341
32MP0004197_abnormal_fetal_growth/weight/1.66910615
33MP0002098_abnormal_vibrissa_morphology1.64512367
34MP0008438_abnormal_cutaneous_collagen1.64114998
35MP0003567_abnormal_fetal_cardiomyocyte1.63889138
36MP0009931_abnormal_skin_appearance1.62957295
37MP0003045_fibrosis1.61371446
38MP0003763_abnormal_thymus_physiology1.61098896
39MP0001730_embryonic_growth_arrest1.61047074
40MP0003119_abnormal_digestive_system1.53823993
41MP0002085_abnormal_embryonic_tissue1.51840583
42MP0002234_abnormal_pharynx_morphology1.51348724
43MP0010771_integument_phenotype1.50869809
44MP0004185_abnormal_adipocyte_glucose1.49598569
45MP0010307_abnormal_tumor_latency1.49082462
46MP0000534_abnormal_ureter_morphology1.47764771
47MP0005023_abnormal_wound_healing1.45827614
48MP0000377_abnormal_hair_follicle1.45703294
49MP0001672_abnormal_embryogenesis/_devel1.44683618
50MP0005380_embryogenesis_phenotype1.44683618
51MP0002086_abnormal_extraembryonic_tissu1.42281020
52MP0000350_abnormal_cell_proliferation1.41105271
53MP0001502_abnormal_circadian_rhythm1.40434394
54MP0002006_tumorigenesis1.40307287
55MP0003984_embryonic_growth_retardation1.38154239
56MP0004272_abnormal_basement_membrane1.38008655
57MP0002088_abnormal_embryonic_growth/wei1.37847474
58MP0009053_abnormal_anal_canal1.37742728
59MP0003123_paternal_imprinting1.36429205
60MP0000566_synostosis1.35224112
61MP0003115_abnormal_respiratory_system1.34743405
62MP0001697_abnormal_embryo_size1.33309243
63MP0000013_abnormal_adipose_tissue1.32424009
64MP0004957_abnormal_blastocyst_morpholog1.30816472
65MP0001348_abnormal_lacrimal_gland1.29019695
66MP0003453_abnormal_keratinocyte_physiol1.27615570
67MP0004381_abnormal_hair_follicle1.27189020
68MP0005275_abnormal_skin_tensile1.26205633
69MP0004782_abnormal_surfactant_physiolog1.26052080
70MP0005377_hearing/vestibular/ear_phenot1.25696098
71MP0003878_abnormal_ear_physiology1.25696098
72MP0000428_abnormal_craniofacial_morphol1.25679191
73MP0000685_abnormal_immune_system1.24911162
74MP0002166_altered_tumor_susceptibility1.23582394
75MP0002925_abnormal_cardiovascular_devel1.21802947
76MP0004147_increased_porphyrin_level1.21778544
77MP0010630_abnormal_cardiac_muscle1.20415163
78MP0003221_abnormal_cardiomyocyte_apopto1.19640422
79MP0002080_prenatal_lethality1.17733784
80MP0003942_abnormal_urinary_system1.17405818
81MP0003077_abnormal_cell_cycle1.16988782
82MP0003890_abnormal_embryonic-extraembry1.16926845
83MP0000383_abnormal_hair_follicle1.16598964
84MP0000003_abnormal_adipose_tissue1.16496844
85MP0009840_abnormal_foam_cell1.16050432
86MP0003091_abnormal_cell_migration1.15198095
87MP0005000_abnormal_immune_tolerance1.13368397
88MP0000750_abnormal_muscle_regeneration1.07168238
89MP0003935_abnormal_craniofacial_develop1.06763056
90MP0002092_abnormal_eye_morphology1.06080054
91MP0005375_adipose_tissue_phenotype1.05856933
92MP0003303_peritoneal_inflammation1.04654667
93MP0005058_abnormal_lysosome_morphology1.02558344
94MP0001915_intracranial_hemorrhage1.01676832
95MP0005257_abnormal_intraocular_pressure1.01163623
96MP0003111_abnormal_nucleus_morphology1.01140666
97MP0006054_spinal_hemorrhage0.99603305
98MP0001727_abnormal_embryo_implantation0.98808626
99MP0004885_abnormal_endolymph0.98213155
100MP0002697_abnormal_eye_size0.97927357
101MP0009333_abnormal_splenocyte_physiolog0.96969233
102MP0002111_abnormal_tail_morphology0.96420082
103MP0010678_abnormal_skin_adnexa0.94796906
104MP0004264_abnormal_extraembryonic_tissu0.94230842
105MP0000465_gastrointestinal_hemorrhage0.94042472
106MP0004087_abnormal_muscle_fiber0.93822244
107MP0005666_abnormal_adipose_tissue0.93621589
108MP0000627_abnormal_mammary_gland0.93201799
109MP0008770_decreased_survivor_rate0.93103956
110MP0002796_impaired_skin_barrier0.93010492
111MP0008775_abnormal_heart_ventricle0.92115156
112MP0005621_abnormal_cell_physiology0.92066787
113MP0000367_abnormal_coat/_hair0.91227599
114MP0003693_abnormal_embryo_hatching0.89980919
115MP0005501_abnormal_skin_physiology0.88921671
116MP0000467_abnormal_esophagus_morphology0.88682443
117MP0003279_aneurysm0.87938683
118MP0001545_abnormal_hematopoietic_system0.87494789
119MP0005397_hematopoietic_system_phenotyp0.87494789
120MP0006138_congestive_heart_failure0.87426158
121MP0001243_abnormal_dermal_layer0.87270629
122MP0002089_abnormal_postnatal_growth/wei0.86235441
123MP0003861_abnormal_nervous_system0.85785701
124MP0003385_abnormal_body_wall0.85227680
125MP0003329_amyloid_beta_deposits0.84809455
126MP0002909_abnormal_adrenal_gland0.84549687
127MP0001293_anophthalmia0.84431043
128MP0001661_extended_life_span0.84194007
129MP0000266_abnormal_heart_morphology0.83425469
130MP0008007_abnormal_cellular_replicative0.81959614
131MP0002269_muscular_atrophy0.81551276
132MP0003937_abnormal_limbs/digits/tail_de0.81499082
133MP0001340_abnormal_eyelid_morphology0.80720224
134MP0000762_abnormal_tongue_morphology0.80283484
135MP0005167_abnormal_blood-brain_barrier0.80199161
136MP0000432_abnormal_head_morphology0.80134186
137MP0000477_abnormal_intestine_morphology0.80060703
138MP0005187_abnormal_penis_morphology0.79987958
139MP0002933_joint_inflammation0.79751651
140MP0002932_abnormal_joint_morphology0.79463206
141MP0002896_abnormal_bone_mineralization0.78814903
142MP0008932_abnormal_embryonic_tissue0.77628023
143MP0001784_abnormal_fluid_regulation0.77543556
144MP0003755_abnormal_palate_morphology0.77262882
145MP0002722_abnormal_immune_system0.76858289
146MP0002723_abnormal_immune_serum0.76524685
147MP0004808_abnormal_hematopoietic_stem0.76448482
148* MP0001614_abnormal_blood_vessel0.75918594
149MP0001191_abnormal_skin_condition0.75148100
150MP0002060_abnormal_skin_morphology0.74874797
151MP0003315_abnormal_perineum_morphology0.74050692
152MP0002398_abnormal_bone_marrow0.72984542
153MP0009672_abnormal_birth_weight0.72189814
154MP0005171_absent_coat_pigmentation0.71232308
155MP0000703_abnormal_thymus_morphology0.71216101
156MP0002019_abnormal_tumor_incidence0.67349804
157MP0005394_taste/olfaction_phenotype0.66943089
158MP0005499_abnormal_olfactory_system0.66943089
159MP0001853_heart_inflammation0.66456051
160MP0002452_abnormal_antigen_presenting0.64659347
161MP0010155_abnormal_intestine_physiology0.62622809
162MP0002429_abnormal_blood_cell0.61382666
163MP0002148_abnormal_hypersensitivity_rea0.61159874
164MP0001819_abnormal_immune_cell0.60106310

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)6.39468196
2Abnormal gallbladder physiology (HP:0012438)5.92127411
3Cholecystitis (HP:0001082)5.92127411
4Onycholysis (HP:0001806)4.97395216
5Thick nail (HP:0001805)4.37257139
6Plantar hyperkeratosis (HP:0007556)4.22047501
7Reticulocytosis (HP:0001923)4.17038910
8Fragile nails (HP:0001808)4.05102143
9Nail dystrophy (HP:0008404)3.81160063
10Shallow orbits (HP:0000586)3.61071170
11Hyperacusis (HP:0010780)3.54577814
12Alopecia of scalp (HP:0002293)3.49546574
13Cerebral aneurysm (HP:0004944)3.30694460
14Palmoplantar hyperkeratosis (HP:0000972)3.21059683
15Cholelithiasis (HP:0001081)3.17667290
16Protrusio acetabuli (HP:0003179)3.08374068
17Pterygium (HP:0001059)3.03387921
18Increased IgE level (HP:0003212)2.99917455
19Abnormality of reticulocytes (HP:0004312)2.99629017
20Ependymoma (HP:0002888)2.97547143
21Abnormality of the astrocytes (HP:0100707)2.95895116
22Astrocytoma (HP:0009592)2.95895116
23Abnormal blistering of the skin (HP:0008066)2.90870477
24Palmar hyperkeratosis (HP:0010765)2.90812831
25Upper limb muscle weakness (HP:0003484)2.86619013
26Renal duplication (HP:0000075)2.75612142
27Bowel diverticulosis (HP:0005222)2.74941004
28Erythema (HP:0010783)2.72313484
29Enlarged penis (HP:0000040)2.71109597
30Long palpebral fissure (HP:0000637)2.60221083
31Ridged nail (HP:0001807)2.59340636
32Squamous cell carcinoma (HP:0002860)2.58921259
33Bladder diverticulum (HP:0000015)2.58548633
34Distal upper limb amyotrophy (HP:0007149)2.58411063
35Upper limb amyotrophy (HP:0009129)2.58411063
36Hand muscle atrophy (HP:0009130)2.58215741
37Abnormal gallbladder morphology (HP:0012437)2.55963559
38Ankle contracture (HP:0006466)2.50271197
39Abnormality of glycolysis (HP:0004366)2.50011264
40Elfin facies (HP:0004428)2.47554020
41Lip pit (HP:0100267)2.44841014
42Ectropion (HP:0000656)2.44027302
43Hypotrichosis (HP:0001006)2.43630598
44Atrophic scars (HP:0001075)2.40256871
45Hypercortisolism (HP:0001578)2.40249074
46Segmental peripheral demyelination/remyelination (HP:0003481)2.38936223
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38804871
48Ulnar bowing (HP:0003031)2.37368498
49Rectal prolapse (HP:0002035)2.33269923
50Breast hypoplasia (HP:0003187)2.32945262
51Premature rupture of membranes (HP:0001788)2.32677252
52Peripheral hypomyelination (HP:0007182)2.32181989
53Overriding aorta (HP:0002623)2.30675799
54Genu recurvatum (HP:0002816)2.28952661
55Insomnia (HP:0100785)2.28640711
56Aneurysm (HP:0002617)2.25330880
57Renovascular hypertension (HP:0100817)2.24201230
58Poikiloderma (HP:0001029)2.23157375
59Vertebral compression fractures (HP:0002953)2.22207639
60Milia (HP:0001056)2.20568334
61Abnormality of the lower motor neuron (HP:0002366)2.19902396
62Macroorchidism (HP:0000053)2.19043043
63Subacute progressive viral hepatitis (HP:0006572)2.18857544
64Hammertoe (HP:0001765)2.18554580
65Pseudobulbar signs (HP:0002200)2.16969888
66Entropion (HP:0000621)2.16920071
67Abnormality of the gallbladder (HP:0005264)2.15705873
68Increased nuchal translucency (HP:0010880)2.15108818
69Interstitial pulmonary disease (HP:0006530)2.13011631
70Oral leukoplakia (HP:0002745)2.11080318
71Short 4th metacarpal (HP:0010044)2.10820395
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10820395
73Pustule (HP:0200039)2.08964245
74Mitral valve prolapse (HP:0001634)2.07714232
75Back pain (HP:0003418)2.07254441
76Fatigue (HP:0012378)2.05806968
77Ragged-red muscle fibers (HP:0003200)2.05691877
78Flat cornea (HP:0007720)2.05452444
79Abnormality of the 4th metacarpal (HP:0010012)2.00089266
80Malignant gastrointestinal tract tumors (HP:0006749)1.99359413
81Gastrointestinal carcinoma (HP:0002672)1.99359413
82Increased connective tissue (HP:0009025)1.99107145
83Abnormality of the salivary glands (HP:0010286)1.98460676
84Natal tooth (HP:0000695)1.97486700
85Glioma (HP:0009733)1.97457025
86Broad face (HP:0000283)1.96090749
87Deviation of the hallux (HP:0010051)1.95600411
88Abnormal hair laboratory examination (HP:0003328)1.93724615
89Pointed chin (HP:0000307)1.93679714
90Biconcave vertebral bodies (HP:0004586)1.93052123
91Ankyloglossia (HP:0010296)1.91585066
92Selective tooth agenesis (HP:0001592)1.91153119
93Atelectasis (HP:0100750)1.90760777
94Axonal loss (HP:0003447)1.90263986
95Difficulty climbing stairs (HP:0003551)1.89762074
96Broad metatarsal (HP:0001783)1.89322859
97Hallux valgus (HP:0001822)1.87573231
98Elbow flexion contracture (HP:0002987)1.86696213
99Dilatation of the ascending aorta (HP:0005111)1.86466727
100Aortic aneurysm (HP:0004942)1.86338635
101Heterotopia (HP:0002282)1.86026489
102Rhabdomyolysis (HP:0003201)1.85781522
103Diaphragmatic weakness (HP:0009113)1.85684554
104Anonychia (HP:0001798)1.85648149
105Myoglobinuria (HP:0002913)1.85153742
106Deviation of the thumb (HP:0009603)1.83487027
107Blepharitis (HP:0000498)1.81564121
108Achilles tendon contracture (HP:0001771)1.81326782
109Missing ribs (HP:0000921)1.80365828
110White forelock (HP:0002211)1.80100083
111Popliteal pterygium (HP:0009756)1.78962804
112Vertebral hypoplasia (HP:0008417)1.77720605
113Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77720605
114Fragile skin (HP:0001030)1.77606015
115Growth hormone excess (HP:0000845)1.77604236
116Sparse scalp hair (HP:0002209)1.77500604
117Intestinal polyp (HP:0005266)1.77386570
118Fibroma (HP:0010614)1.76174409
119Conical tooth (HP:0000698)1.75847641
120Abnormality of oral frenula (HP:0000190)1.75811082
121Exercise-induced muscle cramps (HP:0003710)1.75289776
122Striae distensae (HP:0001065)1.74098816
123Neoplasm of the oral cavity (HP:0100649)1.73560725
124Annular pancreas (HP:0001734)1.72305323
125Nuclear cataract (HP:0100018)1.71982301
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71962224
127Broad thumb (HP:0011304)1.71885975
128Lymphangioma (HP:0100764)1.71808054
129Megalocornea (HP:0000485)1.71703800
130Advanced eruption of teeth (HP:0006288)1.71494582
131Hypertensive crisis (HP:0100735)1.70964795
132Corneal erosion (HP:0200020)1.70923162
133Proximal placement of thumb (HP:0009623)1.70524457
134Myopathic facies (HP:0002058)1.69977383
135Intestinal polyposis (HP:0200008)1.69759813
136Turricephaly (HP:0000262)1.69731105
137Dysautonomia (HP:0002459)1.69210977
138Esophageal atresia (HP:0002032)1.68890831
139Fibrous tissue neoplasm (HP:0012316)1.68624945
140Biliary tract neoplasm (HP:0100574)1.68556916
141Septate vagina (HP:0001153)1.67853242
142Right ventricular cardiomyopathy (HP:0011663)1.67401763
143Increased density of long bones (HP:0006392)1.67052149
144Broad palm (HP:0001169)1.66945628
145Bowed forearm bones (HP:0003956)1.66455616
146Bowing of the arm (HP:0006488)1.66455616
147Neurofibrillary tangles (HP:0002185)1.66002200
148Aplasia cutis congenita (HP:0001057)1.65864673
149Dry hair (HP:0011359)1.65399084
150Distal sensory impairment (HP:0002936)1.65283345
151Rib fusion (HP:0000902)1.63790328
152Arnold-Chiari malformation (HP:0002308)1.63630092
153Neoplasm of the heart (HP:0100544)1.63121336
154Metaphyseal cupping (HP:0003021)1.63083920
155Abnormality of the diencephalon (HP:0010662)1.62825195
156Erythroderma (HP:0001019)1.62596814
157Basal cell carcinoma (HP:0002671)1.62509312
158Difficulty running (HP:0009046)1.62466390
159Abnormality of the calcaneus (HP:0008364)1.61252637
160Truncus arteriosus (HP:0001660)1.60993567
161High anterior hairline (HP:0009890)1.60920157
162Vertebral arch anomaly (HP:0008438)1.60903482
163Pili torti (HP:0003777)1.60575248
164Distal lower limb amyotrophy (HP:0008944)1.60245564
165Dysmetric saccades (HP:0000641)1.59359664
166Abnormality of the fingernails (HP:0001231)1.59117081
167Breech presentation (HP:0001623)1.58886638
168Spina bifida occulta (HP:0003298)1.58079703
169Hyporeflexia of lower limbs (HP:0002600)1.56436985
170Absent eyelashes (HP:0000561)1.56431118
171Posterior subcapsular cataract (HP:0007787)1.56424280
172Disproportionate tall stature (HP:0001519)1.56122921
173Angiofibromas (HP:0010615)1.55997281
174Adenoma sebaceum (HP:0009720)1.55997281
175Scapular winging (HP:0003691)1.55796012
176Bronchomalacia (HP:0002780)1.54487519
177Short phalanx of the thumb (HP:0009660)1.54075687
178Vertebral clefting (HP:0008428)1.53118722
179Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.52484118
180Short 1st metacarpal (HP:0010034)1.52484118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.59046121
2TRIB34.03297785
3PKN24.02065829
4EPHA22.93973516
5PIM22.81641499
6CDK122.68240815
7MAP3K102.56393736
8PDGFRA2.40825674
9IRAK32.39261372
10MST1R2.29256555
11PRPF4B2.25214650
12MAP3K142.24741072
13LATS22.22541813
14PDK22.14802902
15ICK2.07516465
16ARAF2.03378104
17LATS12.01733048
18BCKDK1.93559481
19TYRO31.91140069
20NME21.86923788
21NEK11.84607543
22SMG11.83837295
23DDR21.81898771
24ALK1.80943874
25MAP3K91.76788789
26RIPK11.74407258
27ERN11.73143824
28TTN1.71174390
29PTK61.69359374
30SIK11.68182332
31RPS6KB21.67881983
32NEK21.58635268
33TAOK31.55165060
34BMX1.54815689
35PTK21.53878987
36TBK11.53114129
37FLT31.46154951
38LRRK21.44513571
39MOS1.40420748
40WNK41.38040100
41MAP3K131.36060806
42KSR21.33257945
43MTOR1.32824868
44PAK41.28015146
45RET1.22380763
46FGFR41.20270594
47SCYL21.16877766
48MAPK111.16000934
49FGFR11.15139649
50PDGFRB1.13635877
51PRKD31.11550207
52STK101.10994582
53MATK1.07546051
54LMTK21.06218524
55CDK60.99273923
56PAK20.98177361
57IKBKB0.97774143
58RAF10.91915319
59PASK0.89842902
60EPHB10.87343261
61MET0.86612375
62IRAK10.84381517
63TLK10.83922445
64FER0.83893529
65MAP3K80.82577042
66EPHB20.81516085
67TGFBR10.80374611
68PAK60.80256380
69NTRK10.78452284
70CHUK0.76674572
71MAPK70.75338909
72TAOK10.72387651
73NEK60.71994366
74SIK30.71804684
75MAP3K20.71599917
76TAOK20.71427486
77CDK80.70730100
78MAPKAPK30.69359136
79CDK40.68520447
80DYRK1B0.67965704
81TSSK60.67062237
82FGFR30.66235498
83STK30.65830813
84TESK10.64878814
85IKBKE0.64792012
86BRAF0.64703348
87ILK0.64348701
88FGFR20.64111617
89MAP2K20.63070558
90DMPK0.62868950
91MAP3K70.61000949
92KSR10.60597338
93GRK60.59967680
94PRKD20.52842562
95PAK30.52154189
96JAK30.51999708
97SIK20.49961579
98RPS6KA10.49911396
99MAP3K60.49829177
100CDK70.49792284
101RPS6KA50.49769078
102JAK10.49633895
103STK390.48661245
104MAP4K10.48552945
105CAMK1D0.47587044
106BMPR20.47282875
107CAMK1G0.47038186
108BRD40.46960140
109AKT20.46316908
110RPS6KC10.45246093
111RPS6KL10.45246093
112TTK0.45046677
113MARK20.43908539
114ZAP700.42528777
115MAP3K10.42407232
116MAPKAPK20.42289247
117RPS6KA40.41569729
118CHEK10.41424602
119PRKD10.41411761
120CLK10.41371117
121AURKA0.41339133
122PRKCH0.40794451
123CDC70.39368276
124RPS6KA20.38830845
125ERBB20.38078127
126EPHA30.37669767
127GSK3A0.37283986
128CDC42BPA0.36632640
129CDK20.36093642
130PIM10.35562577
131MAPKAPK50.35220747
132RPS6KA60.35038174
133MAPK30.34948631
134STK380.34248084
135PRKCI0.33922891
136CSNK1D0.33776858
137IRAK40.33454320
138HIPK20.32776426
139PAK10.31931127
140MAPK10.31090788
141INSR0.30857576
142JAK20.29910716
143TESK20.29629503

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.57488160
2Pentose phosphate pathway_Homo sapiens_hsa000302.25374065
3Central carbon metabolism in cancer_Homo sapiens_hsa052302.10894770
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05823716
5Chronic myeloid leukemia_Homo sapiens_hsa052201.97105591
6Hippo signaling pathway_Homo sapiens_hsa043901.90577022
7Carbon metabolism_Homo sapiens_hsa012001.90304566
8* mTOR signaling pathway_Homo sapiens_hsa041501.90135811
9Notch signaling pathway_Homo sapiens_hsa043301.89061933
10Adherens junction_Homo sapiens_hsa045201.85351694
11Bladder cancer_Homo sapiens_hsa052191.82610991
12Galactose metabolism_Homo sapiens_hsa000521.75651678
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.67871276
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67333762
15Basal cell carcinoma_Homo sapiens_hsa052171.66718840
16Proteoglycans in cancer_Homo sapiens_hsa052051.66610357
17Endometrial cancer_Homo sapiens_hsa052131.64497595
18Small cell lung cancer_Homo sapiens_hsa052221.59354705
19* MicroRNAs in cancer_Homo sapiens_hsa052061.57671974
20Focal adhesion_Homo sapiens_hsa045101.56810945
21Renal cell carcinoma_Homo sapiens_hsa052111.56653608
22Colorectal cancer_Homo sapiens_hsa052101.52938273
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52596253
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.46664188
25Prion diseases_Homo sapiens_hsa050201.45281544
26Non-small cell lung cancer_Homo sapiens_hsa052231.43749186
27HIF-1 signaling pathway_Homo sapiens_hsa040661.43549719
28VEGF signaling pathway_Homo sapiens_hsa043701.39820528
29TNF signaling pathway_Homo sapiens_hsa046681.37787093
30Hedgehog signaling pathway_Homo sapiens_hsa043401.36557248
31Glioma_Homo sapiens_hsa052141.33169697
32Thyroid cancer_Homo sapiens_hsa052161.31402947
33ECM-receptor interaction_Homo sapiens_hsa045121.31310128
34Tight junction_Homo sapiens_hsa045301.28852784
35Steroid biosynthesis_Homo sapiens_hsa001001.28368380
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27644226
37Pancreatic cancer_Homo sapiens_hsa052121.24809746
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23631977
39Other glycan degradation_Homo sapiens_hsa005111.23333137
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22885635
41Dorso-ventral axis formation_Homo sapiens_hsa043201.21981712
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20798631
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.20375480
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19377412
45Estrogen signaling pathway_Homo sapiens_hsa049151.19327594
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18236675
47mRNA surveillance pathway_Homo sapiens_hsa030151.16701936
48p53 signaling pathway_Homo sapiens_hsa041151.16389270
49Acute myeloid leukemia_Homo sapiens_hsa052211.12563094
50HTLV-I infection_Homo sapiens_hsa051661.11689006
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11593065
52Viral myocarditis_Homo sapiens_hsa054161.08458358
53Insulin resistance_Homo sapiens_hsa049311.06480258
54RNA transport_Homo sapiens_hsa030131.05899299
55Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03537275
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03213677
57Insulin signaling pathway_Homo sapiens_hsa049101.03005434
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02985000
59AMPK signaling pathway_Homo sapiens_hsa041521.02872496
60Pathways in cancer_Homo sapiens_hsa052001.02724187
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00759374
62Lysine degradation_Homo sapiens_hsa003101.00686468
63Viral carcinogenesis_Homo sapiens_hsa052031.00013518
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.99632164
65Wnt signaling pathway_Homo sapiens_hsa043100.99140286
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97394153
67ErbB signaling pathway_Homo sapiens_hsa040120.97010106
68Arginine biosynthesis_Homo sapiens_hsa002200.97009058
69Prolactin signaling pathway_Homo sapiens_hsa049170.96894366
70Amoebiasis_Homo sapiens_hsa051460.94259541
71TGF-beta signaling pathway_Homo sapiens_hsa043500.94190691
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93740534
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92523290
74Phenylalanine metabolism_Homo sapiens_hsa003600.89604662
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88306491
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88086253
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87495727
78Herpes simplex infection_Homo sapiens_hsa051680.87274916
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86854006
80Prostate cancer_Homo sapiens_hsa052150.86624754
81Rap1 signaling pathway_Homo sapiens_hsa040150.86263952
82Dilated cardiomyopathy_Homo sapiens_hsa054140.84604008
83Measles_Homo sapiens_hsa051620.82882695
84Hepatitis C_Homo sapiens_hsa051600.82557989
85Melanogenesis_Homo sapiens_hsa049160.81760070
86Cell cycle_Homo sapiens_hsa041100.81572878
87Sulfur relay system_Homo sapiens_hsa041220.81261338
88T cell receptor signaling pathway_Homo sapiens_hsa046600.81201494
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81098693
90FoxO signaling pathway_Homo sapiens_hsa040680.80831400
91Legionellosis_Homo sapiens_hsa051340.80472982
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.79599474
93Primary immunodeficiency_Homo sapiens_hsa053400.79494640
94Melanoma_Homo sapiens_hsa052180.78491102
95Toxoplasmosis_Homo sapiens_hsa051450.77426690
96Oocyte meiosis_Homo sapiens_hsa041140.76221626
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76079804
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75885160
99Glucagon signaling pathway_Homo sapiens_hsa049220.75855473
100Influenza A_Homo sapiens_hsa051640.75276553
101Type II diabetes mellitus_Homo sapiens_hsa049300.73002336
102Protein digestion and absorption_Homo sapiens_hsa049740.72751703
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71551985
104Gap junction_Homo sapiens_hsa045400.71379738
105B cell receptor signaling pathway_Homo sapiens_hsa046620.70596280
106* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70268579
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70165007
108Axon guidance_Homo sapiens_hsa043600.69675902
109Endocytosis_Homo sapiens_hsa041440.68583781
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.68061452
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67559521
112Platelet activation_Homo sapiens_hsa046110.67189050
113GnRH signaling pathway_Homo sapiens_hsa049120.67055882
114Salmonella infection_Homo sapiens_hsa051320.65456990
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64883207
116Apoptosis_Homo sapiens_hsa042100.64791305
117Nitrogen metabolism_Homo sapiens_hsa009100.63897309
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.63682319
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63431929
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.62607320
121Spliceosome_Homo sapiens_hsa030400.62318943
122MAPK signaling pathway_Homo sapiens_hsa040100.62234878
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61674746
124Epstein-Barr virus infection_Homo sapiens_hsa051690.60637836
125Hepatitis B_Homo sapiens_hsa051610.60148787
126Shigellosis_Homo sapiens_hsa051310.59867511
127Systemic lupus erythematosus_Homo sapiens_hsa053220.59859467
128Choline metabolism in cancer_Homo sapiens_hsa052310.59696982
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.59548352
130Fatty acid biosynthesis_Homo sapiens_hsa000610.59437513
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59043998
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58335102
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57792095
134Fructose and mannose metabolism_Homo sapiens_hsa000510.57126830
135Base excision repair_Homo sapiens_hsa034100.56475292
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56425779
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56071648
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53882329
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52147089
140One carbon pool by folate_Homo sapiens_hsa006700.49745544
141Alcoholism_Homo sapiens_hsa050340.49183835
142Circadian rhythm_Homo sapiens_hsa047100.49159473
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44332605
144Malaria_Homo sapiens_hsa051440.42063168
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.41508337
146Arginine and proline metabolism_Homo sapiens_hsa003300.40448529
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39793538

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