DDIT4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.25516743
2actin-myosin filament sliding (GO:0033275)7.81507022
3muscle filament sliding (GO:0030049)7.81507022
4regulation of relaxation of muscle (GO:1901077)7.53906712
5skeletal muscle contraction (GO:0003009)6.99317708
6actin-mediated cell contraction (GO:0070252)6.71501174
7skeletal muscle adaptation (GO:0043501)6.51875266
8sarcoplasmic reticulum calcium ion transport (GO:0070296)6.51507474
9skeletal muscle fiber development (GO:0048741)5.67308758
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.50827420
11myotube cell development (GO:0014904)5.29841781
12actin filament-based movement (GO:0030048)4.84491245
13cardiac myofibril assembly (GO:0055003)4.74761638
14glycogen catabolic process (GO:0005980)4.72029851
15skeletal muscle tissue regeneration (GO:0043403)4.68766384
16cardiac muscle contraction (GO:0060048)4.57707877
17purine nucleotide salvage (GO:0032261)4.56864358
18glucan catabolic process (GO:0009251)4.34329587
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.24307727
20regulation of actin filament-based movement (GO:1903115)4.23425760
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.22085399
22striated muscle contraction (GO:0006941)4.20231025
23muscle cell fate commitment (GO:0042693)4.14558877
24regulation of cell communication by electrical coupling (GO:0010649)4.14544525
25NADH metabolic process (GO:0006734)4.11000426
26cellular polysaccharide catabolic process (GO:0044247)4.09055826
27regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.07429430
28cardiac muscle hypertrophy (GO:0003300)4.07024514
29response to pheromone (GO:0019236)4.00603901
30fructose metabolic process (GO:0006000)3.99486615
31response to gravity (GO:0009629)3.97341765
32negative regulation of potassium ion transmembrane transport (GO:1901380)3.91320136
33otic vesicle formation (GO:0030916)3.89196779
34polysaccharide catabolic process (GO:0000272)3.88914678
35striated muscle hypertrophy (GO:0014897)3.88078810
36plasma membrane repair (GO:0001778)3.85041203
37gluconeogenesis (GO:0006094)3.84846765
38myofibril assembly (GO:0030239)3.84698595
39muscle contraction (GO:0006936)3.83930946
40IMP metabolic process (GO:0046040)3.83225142
41neuronal action potential propagation (GO:0019227)3.83018840
42muscle hypertrophy (GO:0014896)3.77896510
43notochord development (GO:0030903)3.64685236
44response to muscle activity (GO:0014850)3.62595976
45striated muscle atrophy (GO:0014891)3.62053595
46AMP metabolic process (GO:0046033)3.61734509
47regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60172439
48striated muscle adaptation (GO:0014888)3.57111312
49muscle tissue morphogenesis (GO:0060415)3.53409953
50hexose biosynthetic process (GO:0019319)3.51055963
51muscle fiber development (GO:0048747)3.50684921
52neuromuscular synaptic transmission (GO:0007274)3.50288987
53sarcomere organization (GO:0045214)3.49064639
54tricarboxylic acid cycle (GO:0006099)3.48287318
55muscle system process (GO:0003012)3.42405486
56muscle cell cellular homeostasis (GO:0046716)3.41912562
57myotube differentiation (GO:0014902)3.41305418
58carnitine shuttle (GO:0006853)3.41268514
59positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.39723168
60regulation of sequestering of triglyceride (GO:0010889)3.38764556
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.37547949
622-oxoglutarate metabolic process (GO:0006103)3.36376618
63muscle organ morphogenesis (GO:0048644)3.35775152
64muscle cell development (GO:0055001)3.35295232
65regulation of striated muscle contraction (GO:0006942)3.35044115
66positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.34667264
67IMP biosynthetic process (GO:0006188)3.34405892
68regulation of skeletal muscle cell differentiation (GO:2001014)3.32326121
69ubiquinone biosynthetic process (GO:0006744)3.31094144
70cardiac muscle cell development (GO:0055013)3.30916937
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.29386265
72negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.29063080
73negative regulation of calcium ion transmembrane transport (GO:1903170)3.29063080
74cardiac muscle tissue morphogenesis (GO:0055008)3.28420903
75paraxial mesoderm development (GO:0048339)3.21932774
76adult heart development (GO:0007512)3.19699953
77regulation of acyl-CoA biosynthetic process (GO:0050812)3.19450886
78fatty acid transmembrane transport (GO:1902001)3.18480608
79protein localization to synapse (GO:0035418)3.16164985
80regulation of calcium ion transmembrane transporter activity (GO:1901019)3.15561581
81regulation of calcium ion transmembrane transport (GO:1903169)3.15561581
82glycogen biosynthetic process (GO:0005978)3.15522926
83glucan biosynthetic process (GO:0009250)3.15522926
84potassium ion import (GO:0010107)3.14533758
85heart process (GO:0003015)3.13537951
86heart contraction (GO:0060047)3.13537951
87myoblast fusion (GO:0007520)3.12597151
88muscle organ development (GO:0007517)3.09474993
89negative regulation of muscle contraction (GO:0045932)3.07023444
90retinal rod cell development (GO:0046548)3.06031901
91cardiac cell development (GO:0055006)3.05132875
92galactose catabolic process (GO:0019388)3.04983269
93cardiac muscle adaptation (GO:0014887)3.04714497
94cardiac muscle hypertrophy in response to stress (GO:0014898)3.04714497
95muscle hypertrophy in response to stress (GO:0003299)3.04714497
96muscle structure development (GO:0061061)3.04580131
97response to inactivity (GO:0014854)3.02763673
98regulation of cofactor metabolic process (GO:0051193)3.02077665
99regulation of coenzyme metabolic process (GO:0051196)3.02077665
100positive regulation of myotube differentiation (GO:0010831)3.01827743
101monosaccharide biosynthetic process (GO:0046364)3.00766277
102cell aggregation (GO:0098743)3.00040023
103cartilage condensation (GO:0001502)3.00040023
104ubiquinone metabolic process (GO:0006743)2.99690222
105muscle atrophy (GO:0014889)2.98632987
106positive regulation of synapse maturation (GO:0090129)2.97754637
107actomyosin structure organization (GO:0031032)2.96228229
108calcium ion import (GO:0070509)2.96003255
109regulation of membrane repolarization (GO:0060306)2.92898955
110sialylation (GO:0097503)2.92070936
111creatine metabolic process (GO:0006600)2.90536117
112syncytium formation (GO:0006949)2.89138525
113negative regulation of skeletal muscle tissue development (GO:0048642)2.86889392
114positive regulation of myoblast differentiation (GO:0045663)2.79149420
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72246299
116glycolytic process (GO:0006096)2.72164042
117muscle adaptation (GO:0043500)2.72069838
118cardiac muscle cell action potential (GO:0086001)2.71999445
119negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71247822
120neuromuscular junction development (GO:0007528)2.69244901
121pyrimidine ribonucleoside catabolic process (GO:0046133)2.66551375
122protein hydroxylation (GO:0018126)2.65480820
123cerebellar granule cell differentiation (GO:0021707)2.64128321
124C4-dicarboxylate transport (GO:0015740)2.64020174
125cellular carbohydrate catabolic process (GO:0044275)2.61612321
126glycogen metabolic process (GO:0005977)2.58946302
127response to activity (GO:0014823)2.58768337
128outer ear morphogenesis (GO:0042473)2.58479155
129syncytium formation by plasma membrane fusion (GO:0000768)2.57978007
130regulation of secondary heart field cardioblast proliferation (GO:0003266)2.53926290
131regulation of cardioblast proliferation (GO:0003264)2.53926290
132regulation of meiosis I (GO:0060631)2.53875413
133skeletal muscle tissue development (GO:0007519)2.52943972
134striated muscle cell development (GO:0055002)2.52844935
135cytoplasmic microtubule organization (GO:0031122)2.51782229
136glucan metabolic process (GO:0044042)2.51306642
137cellular glucan metabolic process (GO:0006073)2.51306642
138postsynaptic membrane organization (GO:0001941)2.51040624
139regulation of myoblast differentiation (GO:0045661)2.48668145
140regulation of transforming growth factor beta2 production (GO:0032909)2.46969227
141negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.44216245
142cardiac muscle cell action potential involved in contraction (GO:0086002)2.44194248
143cytidine catabolic process (GO:0006216)2.42670102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.86643899
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.14249661
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.55326977
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91159058
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.60412511
6GBX2_23144817_ChIP-Seq_PC3_Human2.53231289
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.49384774
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.31685902
9AR_21572438_ChIP-Seq_LNCaP_Human2.28031747
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26055478
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.24196840
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.24196840
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20853559
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17304796
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13559594
16BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.02264791
17IGF1R_20145208_ChIP-Seq_DFB_Human1.99588624
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.99237024
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98604315
20MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.94013171
21FUS_26573619_Chip-Seq_HEK293_Human1.93170011
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91898234
23* TP53_20018659_ChIP-ChIP_R1E_Mouse1.91634787
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91496307
25EZH2_22144423_ChIP-Seq_EOC_Human1.90823213
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90168759
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90168759
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.89448541
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.88734682
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87390288
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85971099
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84011329
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83053309
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80763240
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78283883
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71510869
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71438442
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71415712
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.67244588
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.65470282
41GATA4_21415370_ChIP-Seq_HL-1_Mouse1.63361452
42NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62921715
43P53_22127205_ChIP-Seq_FIBROBLAST_Human1.62576821
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61579410
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60707978
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58875587
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57416601
48* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55508552
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.54849256
50* EZH2_27294783_Chip-Seq_ESCs_Mouse1.54723471
51ZNF263_19887448_ChIP-Seq_K562_Human1.54017324
52TAF15_26573619_Chip-Seq_HEK293_Human1.53401718
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52944293
54* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51468701
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.49644424
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49079577
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47593590
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45839640
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43642837
60VDR_22108803_ChIP-Seq_LS180_Human1.42063092
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41843543
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41235605
63RNF2_27304074_Chip-Seq_NSC_Mouse1.41129290
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40649876
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34246715
66SMAD4_21799915_ChIP-Seq_A2780_Human1.32480397
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32349553
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.31887125
69* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30037548
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29764763
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24134448
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.23889338
73ZNF274_21170338_ChIP-Seq_K562_Hela1.22927914
74TP53_18474530_ChIP-ChIP_U2OS_Human1.22186877
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19972195
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19542286
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19306502
78AR_25329375_ChIP-Seq_VCAP_Human1.17120775
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16732483
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16468401
81RXR_22108803_ChIP-Seq_LS180_Human1.16447092
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16352449
83CBP_20019798_ChIP-Seq_JUKART_Human1.16352449
84P300_19829295_ChIP-Seq_ESCs_Human1.15033514
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.14161390
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13819765
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13819765
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13113612
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.11630826
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10393816
91CJUN_26792858_Chip-Seq_BT549_Human1.09334815
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.09248641
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09226135
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08228552
95* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07432564
96* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07223876
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06882424
98* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04793591
99SOX9_26525672_Chip-Seq_HEART_Mouse1.04720839
100DROSHA_22980978_ChIP-Seq_HELA_Human1.03795992
101PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02797398
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.01955667
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.00975135
104SOX2_19829295_ChIP-Seq_ESCs_Human1.00446056
105NANOG_19829295_ChIP-Seq_ESCs_Human1.00446056
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.99827710
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99544018
108ER_23166858_ChIP-Seq_MCF-7_Human0.99218335
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97976040
110TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97869622
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.97769856
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97365640
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96907417
114REST_21632747_ChIP-Seq_MESCs_Mouse0.96562565
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96297222
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96165903
117PHF8_20622853_ChIP-Seq_HELA_Human0.95694853
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.95295617
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95106953
120EOMES_21245162_ChIP-Seq_HESCs_Human0.94818864
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94154824
122GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93450440
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93421619
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93421619
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93421619
126AR_19668381_ChIP-Seq_PC3_Human0.92705069
127CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92539268
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91427089
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91133998
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91093511
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90217866
132JUN_21703547_ChIP-Seq_K562_Human0.89507116
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89346649
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89177985
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88872516
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.87155077
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86673135
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86663325
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86053791
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85618921
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85618921
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85300918
143TBL1_22424771_ChIP-Seq_293T_Human0.84809476
144NFI_21473784_ChIP-Seq_ESCs_Mouse0.84689118
145CDX2_22108803_ChIP-Seq_LS180_Human0.84419435
146NFYB_21822215_ChIP-Seq_K562_Human0.83540531
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83525717
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83385409
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82322650
150* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82117927
151ETV1_20927104_ChIP-Seq_GIST48_Human0.81484961
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80359793
153CBP_21632823_ChIP-Seq_H3396_Human0.80065167
154* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79392364
155CTCF_27219007_Chip-Seq_Bcells_Human0.78679533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.27800463
2MP0003646_muscle_fatigue5.39291745
3MP0000749_muscle_degeneration4.57343756
4MP0000751_myopathy4.37859460
5MP0000747_muscle_weakness3.14175938
6MP0002106_abnormal_muscle_physiology3.00974950
7MP0004233_abnormal_muscle_weight2.88216223
8MP0000759_abnormal_skeletal_muscle2.85587313
9MP0000750_abnormal_muscle_regeneration2.81602756
10MP0005451_abnormal_body_composition2.79744026
11MP0004036_abnormal_muscle_relaxation2.76566923
12MP0005369_muscle_phenotype2.69452847
13MP0005620_abnormal_muscle_contractility2.55834417
14MP0002269_muscular_atrophy2.52347845
15MP0002108_abnormal_muscle_morphology2.41365941
16MP0004087_abnormal_muscle_fiber2.17602848
17MP0009250_abnormal_appendicular_skeleto2.17341447
18MP0002332_abnormal_exercise_endurance1.96847850
19MP0004130_abnormal_muscle_cell1.91669301
20MP0000733_abnormal_muscle_development1.82430570
21MP0010030_abnormal_orbit_morphology1.78392436
22MP0005503_abnormal_tendon_morphology1.71697658
23MP0004215_abnormal_myocardial_fiber1.67492192
24MP0003941_abnormal_skin_development1.65728190
25MP0000762_abnormal_tongue_morphology1.64422445
26MP0004134_abnormal_chest_morphology1.59713628
27MP0002837_dystrophic_cardiac_calcinosis1.52462804
28MP0009384_cardiac_valve_regurgitation1.50788605
29MP0004270_analgesia1.45794399
30MP0009780_abnormal_chondrocyte_physiolo1.42470477
31MP0010630_abnormal_cardiac_muscle1.41982153
32MP0000049_abnormal_middle_ear1.38813915
33MP0001346_abnormal_lacrimal_gland1.37817410
34MP0001661_extended_life_span1.33673642
35MP0006292_abnormal_olfactory_placode1.33012359
36MP0002089_abnormal_postnatal_growth/wei1.30960069
37MP0002234_abnormal_pharynx_morphology1.26117786
38MP0003755_abnormal_palate_morphology1.21266712
39MP0001544_abnormal_cardiovascular_syste1.17625985
40MP0005385_cardiovascular_system_phenoty1.17625985
41MP0003137_abnormal_impulse_conducting1.11545532
42MP0003950_abnormal_plasma_membrane1.10223873
43MP0000163_abnormal_cartilage_morphology1.09296842
44MP0006138_congestive_heart_failure1.08740577
45MP0004484_altered_response_of1.08434474
46MP0004859_abnormal_synaptic_plasticity1.07160434
47MP0002653_abnormal_ependyma_morphology1.07149995
48MP0005666_abnormal_adipose_tissue1.06874236
49MP0004084_abnormal_cardiac_muscle1.03812358
50MP0004043_abnormal_pH_regulation1.02601866
51MP0002249_abnormal_larynx_morphology1.02059694
52MP0005670_abnormal_white_adipose1.01872305
53MP0000631_abnormal_neuroendocrine_gland1.01723312
54MP0001299_abnormal_eye_distance/1.01479421
55MP0003880_abnormal_central_pattern1.01193361
56MP0002127_abnormal_cardiovascular_syste1.00774460
57MP0000566_synostosis1.00740820
58MP0003221_abnormal_cardiomyocyte_apopto1.00149654
59MP0005508_abnormal_skeleton_morphology0.98184682
60MP0008004_abnormal_stomach_pH0.98015147
61MP0004510_myositis0.97029731
62MP0004185_abnormal_adipocyte_glucose0.97026939
63MP0002115_abnormal_skeleton_extremities0.96125012
64MP0002896_abnormal_bone_mineralization0.94777204
65MP0005275_abnormal_skin_tensile0.94625370
66MP0001542_abnormal_bone_strength0.93533081
67MP0002233_abnormal_nose_morphology0.92900641
68MP0000372_irregular_coat_pigmentation0.91270344
69MP0002109_abnormal_limb_morphology0.90548325
70MP0002116_abnormal_craniofacial_bone0.89039997
71MP0003879_abnormal_hair_cell0.89028737
72MP0000678_abnormal_parathyroid_gland0.88622579
73MP0005623_abnormal_meninges_morphology0.86610153
74MP0000003_abnormal_adipose_tissue0.85618869
75MP0005330_cardiomyopathy0.85418761
76MP0002114_abnormal_axial_skeleton0.84095482
77MP0008775_abnormal_heart_ventricle0.83002391
78MP0002972_abnormal_cardiac_muscle0.82605006
79MP0003937_abnormal_limbs/digits/tail_de0.81192156
80MP0005551_abnormal_eye_electrophysiolog0.80932388
81MP0004782_abnormal_surfactant_physiolog0.79909623
82MP0004147_increased_porphyrin_level0.79760367
83MP0001502_abnormal_circadian_rhythm0.79346186
84MP0008789_abnormal_olfactory_epithelium0.76359592
85MP0001486_abnormal_startle_reflex0.76144111
86MP0005248_abnormal_Harderian_gland0.73582330
87MP0000432_abnormal_head_morphology0.71196735
88MP0002282_abnormal_trachea_morphology0.71194266
89MP0003635_abnormal_synaptic_transmissio0.70605863
90MP0000534_abnormal_ureter_morphology0.70123713
91MP0001984_abnormal_olfaction0.69195928
92MP0002113_abnormal_skeleton_development0.69080062
93MP0008961_abnormal_basal_metabolism0.66989363
94MP0008260_abnormal_autophagy0.66854827
95MP0005171_absent_coat_pigmentation0.66608780
96MP0003279_aneurysm0.66275338
97MP0005266_abnormal_metabolism0.65646967
98MP0005646_abnormal_pituitary_gland0.64551851
99MP0006036_abnormal_mitochondrial_physio0.64012451
100MP0000266_abnormal_heart_morphology0.63770436
101MP0003385_abnormal_body_wall0.63715581
102MP0002932_abnormal_joint_morphology0.63703616
103MP0000428_abnormal_craniofacial_morphol0.62770499
104MP0009697_abnormal_copulation0.60994492
105MP0001270_distended_abdomen0.60271336
106MP0004142_abnormal_muscle_tone0.60176537
107MP0004085_abnormal_heartbeat0.59552887
108MP0003011_delayed_dark_adaptation0.59471807
109MP0005595_abnormal_vascular_smooth0.58882964
110MP0002063_abnormal_learning/memory/cond0.58738372
111MP0003935_abnormal_craniofacial_develop0.57669612
112MP0003938_abnormal_ear_development0.56977492
113MP0009672_abnormal_birth_weight0.56508825
114MP0002078_abnormal_glucose_homeostasis0.55629079
115MP0002971_abnormal_brown_adipose0.55175828
116MP0000013_abnormal_adipose_tissue0.54605493
117MP0005375_adipose_tissue_phenotype0.52761572
118MP0010368_abnormal_lymphatic_system0.52636288
119MP0008438_abnormal_cutaneous_collagen0.51818541
120MP0003959_abnormal_lean_body0.51436445
121MP0002067_abnormal_sensory_capabilities0.50716154
122MP0003942_abnormal_urinary_system0.48858954
123MP0003136_yellow_coat_color0.48097511
124MP0005332_abnormal_amino_acid0.47540406
125MP0003045_fibrosis0.46146881
126MP0003806_abnormal_nucleotide_metabolis0.45728363
127MP0005452_abnormal_adipose_tissue0.44909938
128MP0008569_lethality_at_weaning0.44436374
129MP0005376_homeostasis/metabolism_phenot0.42196534
130MP0002822_catalepsy0.38800215
131MP0005334_abnormal_fat_pad0.38186948
132MP0005535_abnormal_body_temperature0.37710964
133MP0002128_abnormal_blood_circulation0.37190135
134MP0005584_abnormal_enzyme/coenzyme_acti0.36688466
135MP0005167_abnormal_blood-brain_barrier0.35233742
136MP0002734_abnormal_mechanical_nocicepti0.33965869
137MP0002638_abnormal_pupillary_reflex0.33480570
138MP0005187_abnormal_penis_morphology0.32468091
139MP0004197_abnormal_fetal_growth/weight/0.28757748
140MP0003828_pulmonary_edema0.28752425
141MP0000230_abnormal_systemic_arterial0.28246467
142MP0009703_decreased_birth_body0.26420907
143MP0004272_abnormal_basement_membrane0.26184401

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.77755565
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.48150260
3Exercise-induced myalgia (HP:0003738)7.23625137
4Nemaline bodies (HP:0003798)7.01242352
5Exercise-induced muscle cramps (HP:0003710)6.30242187
6Type 1 muscle fiber predominance (HP:0003803)6.15251604
7Round ear (HP:0100830)5.72063385
8Myopathic facies (HP:0002058)5.50805055
9Distal arthrogryposis (HP:0005684)5.43747272
10Ulnar deviation of the wrist (HP:0003049)5.30075589
11Muscle hypertrophy of the lower extremities (HP:0008968)5.02570093
12Calf muscle hypertrophy (HP:0008981)4.41501393
13Muscle fiber splitting (HP:0003555)4.24088245
14Centrally nucleated skeletal muscle fibers (HP:0003687)4.14848788
15Calcaneovalgus deformity (HP:0001848)4.12758653
16Absent phalangeal crease (HP:0006109)3.93559236
17Abnormality of the calf musculature (HP:0001430)3.82602149
18Myoglobinuria (HP:0002913)3.81992731
19Deformed tarsal bones (HP:0008119)3.75891318
20Shoulder girdle muscle weakness (HP:0003547)3.57650453
21Difficulty running (HP:0009046)3.56036996
22Hypoplastic ischia (HP:0003175)3.55268411
23Muscle stiffness (HP:0003552)3.38257023
24EMG: myopathic abnormalities (HP:0003458)3.34415449
25Abnormal finger flexion creases (HP:0006143)3.31359562
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.26532671
27Increased connective tissue (HP:0009025)3.21260007
28Abnormality of the hip-girdle musculature (HP:0001445)3.15249887
29Abnormality of the musculature of the pelvis (HP:0001469)3.15249887
30Pelvic girdle muscle weakness (HP:0003749)3.12984919
31Septo-optic dysplasia (HP:0100842)3.11377909
32Rhabdomyolysis (HP:0003201)3.09359313
33Abnormality of the ischium (HP:0003174)3.06524515
34Myotonia (HP:0002486)2.95027009
35Asymmetric septal hypertrophy (HP:0001670)2.87720600
36Hyporeflexia of lower limbs (HP:0002600)2.80035457
37Abnormality of skeletal muscle fiber size (HP:0012084)2.78757411
38Waddling gait (HP:0002515)2.77860721
39Metaphyseal cupping (HP:0003021)2.76467533
40Sudden death (HP:0001699)2.74615079
41Rimmed vacuoles (HP:0003805)2.71739044
42Abnormality of the calcaneus (HP:0008364)2.68469707
43Focal motor seizures (HP:0011153)2.67484830
44Neck muscle weakness (HP:0000467)2.63781860
45Increased variability in muscle fiber diameter (HP:0003557)2.59074145
46Hyperkalemia (HP:0002153)2.58483489
47Hip contracture (HP:0003273)2.56627324
48Bulbar palsy (HP:0001283)2.51112169
49Difficulty climbing stairs (HP:0003551)2.50079551
50Areflexia of lower limbs (HP:0002522)2.49034493
51Dilated cardiomyopathy (HP:0001644)2.44508325
52Bundle branch block (HP:0011710)2.38672108
53Weak cry (HP:0001612)2.37193554
54Malignant hyperthermia (HP:0002047)2.36840366
55Slender build (HP:0001533)2.34140447
56Fetal akinesia sequence (HP:0001989)2.32721682
57Nonprogressive disorder (HP:0003680)2.29150785
58Abnormality of the shoulder girdle musculature (HP:0001435)2.28197642
59Limb-girdle muscle weakness (HP:0003325)2.24926396
60Muscular dystrophy (HP:0003560)2.24266448
61Distal lower limb muscle weakness (HP:0009053)2.23095832
62Frequent falls (HP:0002359)2.19558936
63Irregular epiphyses (HP:0010582)2.18861975
64Limited hip movement (HP:0008800)2.16805627
65Subaortic stenosis (HP:0001682)2.16319966
66Abnormality of the left ventricular outflow tract (HP:0011103)2.16319966
67Metaphyseal dysplasia (HP:0100255)2.16079882
68Neonatal short-limb short stature (HP:0008921)2.14395677
69Mesomelia (HP:0003027)2.13009890
70Limb-girdle muscle atrophy (HP:0003797)2.09493874
71Increased purine levels (HP:0004368)2.09445891
72Hyperuricemia (HP:0002149)2.09445891
73Distal lower limb amyotrophy (HP:0008944)2.09033203
74Progressive muscle weakness (HP:0003323)2.08118553
75Lipoatrophy (HP:0100578)2.04688103
76Spinal rigidity (HP:0003306)2.04105858
77Proximal amyotrophy (HP:0007126)1.96522850
78Epileptic encephalopathy (HP:0200134)1.94685393
79Long clavicles (HP:0000890)1.93974263
80Ventricular tachycardia (HP:0004756)1.93171030
81Genu varum (HP:0002970)1.92202135
82Flat capital femoral epiphysis (HP:0003370)1.90164708
83Abnormality of the pubic bones (HP:0003172)1.88769674
84Exercise intolerance (HP:0003546)1.85803773
85Mild short stature (HP:0003502)1.85370005
86Short palpebral fissure (HP:0012745)1.83521766
87Cupped ribs (HP:0000887)1.82827230
88Epiphyseal dysplasia (HP:0002656)1.82461078
89Wrist flexion contracture (HP:0001239)1.81466905
90Fatigable weakness (HP:0003473)1.80832412
91Abnormality of the neuromuscular junction (HP:0003398)1.80832412
92Scapular winging (HP:0003691)1.80161585
93Mildly elevated creatine phosphokinase (HP:0008180)1.79233710
94Respiratory insufficiency due to muscle weakness (HP:0002747)1.78182601
95Lower limb amyotrophy (HP:0007210)1.77053968
96EMG: neuropathic changes (HP:0003445)1.76151685
97Fibular aplasia (HP:0002990)1.71859174
98Abnormality of the foot musculature (HP:0001436)1.70726861
99Popliteal pterygium (HP:0009756)1.69311389
100Bell-shaped thorax (HP:0001591)1.68969221
101Optic nerve hypoplasia (HP:0000609)1.68685603
102Tarsal synostosis (HP:0008368)1.68413518
103Gowers sign (HP:0003391)1.68097850
104Absence seizures (HP:0002121)1.67888849
105Vitreoretinal degeneration (HP:0000655)1.66817127
106Type 2 muscle fiber atrophy (HP:0003554)1.63413635
107Febrile seizures (HP:0002373)1.63387987
108Gout (HP:0001997)1.62915135
109Absent septum pellucidum (HP:0001331)1.62438282
110Generalized muscle weakness (HP:0003324)1.61816777
111Atonic seizures (HP:0010819)1.58473443
112Ulnar deviation of finger (HP:0009465)1.58033313
113Irregular vertebral endplates (HP:0003301)1.58008144
114Facial diplegia (HP:0001349)1.57147635
115Broad-based gait (HP:0002136)1.57147260
116Abnormality of the vertebral endplates (HP:0005106)1.56848426
117Heart block (HP:0012722)1.55998924
118Foot dorsiflexor weakness (HP:0009027)1.55572368
119Paralysis (HP:0003470)1.54383852
120Synostosis involving bones of the lower limbs (HP:0009138)1.53086417
121Metatarsus adductus (HP:0001840)1.50451243
122Oligomenorrhea (HP:0000876)1.49723036
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.46954172
124Muscle fiber atrophy (HP:0100295)1.45271737
125Abnormality of fatty-acid metabolism (HP:0004359)1.44566473
126Increased muscle lipid content (HP:0009058)1.44283049
127Abnormal atrioventricular conduction (HP:0005150)1.43523552
128Increased intramyocellular lipid droplets (HP:0012240)1.42762997
129Ragged-red muscle fibers (HP:0003200)1.38335407
130Insulin-resistant diabetes mellitus (HP:0000831)1.28511487
131Steppage gait (HP:0003376)1.28352555
132Hypoalphalipoproteinemia (HP:0003233)1.27498201
133Abnormality of potassium homeostasis (HP:0011042)1.25312570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.54812079
2PHKG15.10643920
3PHKG25.10643920
4TTN4.26671865
5NME13.69958887
6CASK3.22860865
7NEK12.72902288
8STK38L2.52029473
9PINK12.35733645
10PIK3CG2.31229290
11CCNB12.04480644
12EPHA41.90148141
13PIK3CA1.81823799
14PDK21.73520622
15PAK61.65494076
16PDK31.64471646
17PDK41.64471646
18MAPK121.61107425
19TAOK21.53729418
20LATS21.52783099
21LATS11.51181599
22DDR21.49357085
23MAP2K31.45394130
24DMPK1.44850593
25MAP3K71.34788993
26EPHA21.34536786
27MAP3K31.29193990
28TAOK11.27286458
29AKT31.25444711
30MUSK1.19319793
31KSR11.17488084
32LIMK11.17332951
33ZAK1.12413351
34ACVR1B1.09984289
35BCKDK1.09328703
36PLK21.07906909
37MAP2K41.06580471
38STK241.04532369
39CDK191.04097434
40KSR21.02635847
41MOS0.99247089
42ERBB30.96388274
43RAF10.92530989
44PRKAA20.86811635
45MAPK70.83520931
46OXSR10.80552656
47NEK60.78581176
48CAMKK20.77950199
49CDK30.77019663
50CDK80.76755483
51PRKAA10.68416245
52NTRK30.66715772
53SGK20.65754098
54DYRK1B0.65497208
55MARK10.65166487
56STK30.63166957
57CAMK40.62742645
58CAMK2G0.62011162
59SGK10.61234105
60CAMK10.59047784
61TNIK0.58882530
62MAP3K110.58648585
63TIE10.57879441
64TGFBR20.54575816
65MKNK20.53820709
66FER0.53121934
67DYRK1A0.52098939
68AKT20.51382075
69PAK30.51046255
70PTK2B0.50232078
71PRKCG0.50226808
72MAP2K60.47003418
73WNK30.46413220
74FGFR10.44361418
75PRPF4B0.44356542
76CAMK2D0.43897151
77PBK0.42911469
78PKN10.42404971
79STK380.39545672
80MAPKAPK30.39303684
81BUB10.39125447
82ROCK10.38946045
83SGK30.37879218
84MAP3K50.35844617
85PLK30.35493631
86TRPM70.35110151
87MAP3K120.34969174
88ARAF0.34467145
89CAMK2A0.32441778
90PRKD30.31701448
91BRAF0.31247422
92MAP3K130.30870878
93EPHA30.30537570
94MAPK100.30381386
95PRKG10.30310254
96PRKACB0.30139634
97CAMK2B0.29765106
98PRKACA0.29308125
99DYRK30.28504942
100TTK0.27998331
101RPS6KB10.27796316
102RPS6KA30.27190765
103PRKCE0.26558399
104RPS6KB20.26408664
105MST40.25150769
106MARK20.24973703
107LMTK20.24907893
108INSRR0.24801755
109MAP2K10.24279661
110MAPK40.24181817
111EEF2K0.23735532
112SGK4940.23664084
113SGK2230.23664084
114DAPK20.23645725
115NEK90.23353708
116CDK180.22713273
117MAP3K10.22395581
118CDK150.22154108
119RPS6KA10.21515614
120PNCK0.20751284
121MAP3K90.20404010
122CDK140.19292816
123PLK10.18998444
124MAP2K70.18550104
125STK160.17171924
126MAP3K100.16358002
127NLK0.15267707
128WNK10.14304676
129RPS6KC10.14215332
130RPS6KL10.14215332
131STK110.13974760
132MAPK110.13232510
133CDC42BPA0.12839786
134PRKACG0.11938930
135RPS6KA60.10000259
136MTOR0.07573372
137EPHB20.05632022
138RIPK10.03596367
139PRKDC0.03338811
140PRKD10.03305166
141CSNK1A10.02832639

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.81622008
2Circadian rhythm_Homo sapiens_hsa047103.75040336
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.53512824
4Dilated cardiomyopathy_Homo sapiens_hsa054142.94564138
5Nicotine addiction_Homo sapiens_hsa050332.89704211
6Oxytocin signaling pathway_Homo sapiens_hsa049212.69314074
7Cardiac muscle contraction_Homo sapiens_hsa042602.50270150
8Propanoate metabolism_Homo sapiens_hsa006402.30331997
9Calcium signaling pathway_Homo sapiens_hsa040202.15836061
10Pyruvate metabolism_Homo sapiens_hsa006201.89327456
11Arginine biosynthesis_Homo sapiens_hsa002201.88972951
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77090930
13Glucagon signaling pathway_Homo sapiens_hsa049221.74685361
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72797364
15Nitrogen metabolism_Homo sapiens_hsa009101.70988183
16ECM-receptor interaction_Homo sapiens_hsa045121.67315728
17Fatty acid degradation_Homo sapiens_hsa000711.64204992
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58648837
19Circadian entrainment_Homo sapiens_hsa047131.58260658
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.56428646
21Parkinsons disease_Homo sapiens_hsa050121.54413518
22Fructose and mannose metabolism_Homo sapiens_hsa000511.51872638
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49302487
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48045962
25Alzheimers disease_Homo sapiens_hsa050101.45931763
26Biosynthesis of amino acids_Homo sapiens_hsa012301.45220693
27Fatty acid elongation_Homo sapiens_hsa000621.44931476
28Starch and sucrose metabolism_Homo sapiens_hsa005001.43281744
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42623027
30GABAergic synapse_Homo sapiens_hsa047271.40772532
31Gastric acid secretion_Homo sapiens_hsa049711.40273596
32Oxidative phosphorylation_Homo sapiens_hsa001901.38982943
33Renin secretion_Homo sapiens_hsa049241.37221679
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37086479
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36890906
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34684582
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33747594
38Fatty acid metabolism_Homo sapiens_hsa012121.30994018
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29456555
40Insulin secretion_Homo sapiens_hsa049111.26816406
41Salivary secretion_Homo sapiens_hsa049701.22877761
42Insulin signaling pathway_Homo sapiens_hsa049101.22404291
43Synaptic vesicle cycle_Homo sapiens_hsa047211.22224145
44Tight junction_Homo sapiens_hsa045301.19105807
45Phenylalanine metabolism_Homo sapiens_hsa003601.18385694
46Hippo signaling pathway_Homo sapiens_hsa043901.14666684
47Focal adhesion_Homo sapiens_hsa045101.14569857
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.13086315
49beta-Alanine metabolism_Homo sapiens_hsa004101.11674968
50Galactose metabolism_Homo sapiens_hsa000521.11172141
51Amphetamine addiction_Homo sapiens_hsa050311.08488225
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06856728
53Long-term potentiation_Homo sapiens_hsa047201.02344101
54Basal cell carcinoma_Homo sapiens_hsa052171.01949337
55GnRH signaling pathway_Homo sapiens_hsa049121.00963581
56mTOR signaling pathway_Homo sapiens_hsa041501.00938666
57Protein digestion and absorption_Homo sapiens_hsa049741.00803886
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99860088
59TGF-beta signaling pathway_Homo sapiens_hsa043500.99129024
60Gap junction_Homo sapiens_hsa045400.98854269
61MAPK signaling pathway_Homo sapiens_hsa040100.98291889
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98163684
63Carbon metabolism_Homo sapiens_hsa012000.97955447
64Arginine and proline metabolism_Homo sapiens_hsa003300.95049053
65Morphine addiction_Homo sapiens_hsa050320.94202444
66Wnt signaling pathway_Homo sapiens_hsa043100.92128014
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90725616
68AMPK signaling pathway_Homo sapiens_hsa041520.90540187
69cAMP signaling pathway_Homo sapiens_hsa040240.90067664
70Insulin resistance_Homo sapiens_hsa049310.89655567
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86161936
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85847201
73Pentose phosphate pathway_Homo sapiens_hsa000300.85674751
74Olfactory transduction_Homo sapiens_hsa047400.85575403
75Huntingtons disease_Homo sapiens_hsa050160.85232626
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.84259165
77Melanoma_Homo sapiens_hsa052180.84071116
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79440137
79FoxO signaling pathway_Homo sapiens_hsa040680.78691540
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76252845
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76031407
82Regulation of autophagy_Homo sapiens_hsa041400.75408530
83Adherens junction_Homo sapiens_hsa045200.74254889
84Melanogenesis_Homo sapiens_hsa049160.71391608
85Hedgehog signaling pathway_Homo sapiens_hsa043400.71158840
86HIF-1 signaling pathway_Homo sapiens_hsa040660.70635283
87PPAR signaling pathway_Homo sapiens_hsa033200.69930371
88Cholinergic synapse_Homo sapiens_hsa047250.69098189
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68660118
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68659090
91Oocyte meiosis_Homo sapiens_hsa041140.68155847
92Mineral absorption_Homo sapiens_hsa049780.67991697
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67504091
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.67346157
95Long-term depression_Homo sapiens_hsa047300.66593089
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.66269842
97Peroxisome_Homo sapiens_hsa041460.63520998
98Serotonergic synapse_Homo sapiens_hsa047260.61797353
99p53 signaling pathway_Homo sapiens_hsa041150.61202185
100Renal cell carcinoma_Homo sapiens_hsa052110.61154193
101Vitamin B6 metabolism_Homo sapiens_hsa007500.61048673
102Collecting duct acid secretion_Homo sapiens_hsa049660.60916614
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58962817
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58488499
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58370500
106Purine metabolism_Homo sapiens_hsa002300.57414052
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55840237
108Axon guidance_Homo sapiens_hsa043600.55125696
109Butanoate metabolism_Homo sapiens_hsa006500.52638572
110Glutamatergic synapse_Homo sapiens_hsa047240.50987069
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50572181
112Basal transcription factors_Homo sapiens_hsa030220.49523119
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49362365
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48560497
115Fatty acid biosynthesis_Homo sapiens_hsa000610.48502657
116Proteoglycans in cancer_Homo sapiens_hsa052050.47744538
117Ovarian steroidogenesis_Homo sapiens_hsa049130.46228403
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44971362
119Dopaminergic synapse_Homo sapiens_hsa047280.44889798
120Glioma_Homo sapiens_hsa052140.43964431
121Tryptophan metabolism_Homo sapiens_hsa003800.40308762
122Cell cycle_Homo sapiens_hsa041100.39663746
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37386825
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37358813
125Vitamin digestion and absorption_Homo sapiens_hsa049770.37144743
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36034116
127RNA degradation_Homo sapiens_hsa030180.34667277
128Glutathione metabolism_Homo sapiens_hsa004800.34278128
129Histidine metabolism_Homo sapiens_hsa003400.33469131
130Metabolic pathways_Homo sapiens_hsa011000.29147985
131Tyrosine metabolism_Homo sapiens_hsa003500.24423968
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23552172
133Thyroid cancer_Homo sapiens_hsa052160.22239848
134Folate biosynthesis_Homo sapiens_hsa007900.22118769
135Lysine degradation_Homo sapiens_hsa003100.21571425
136Sulfur relay system_Homo sapiens_hsa041220.21337868
137ABC transporters_Homo sapiens_hsa020100.21237920
138Dorso-ventral axis formation_Homo sapiens_hsa043200.14673767

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