DDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.79677785
2synaptic vesicle maturation (GO:0016188)6.70928897
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.56318318
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.50840399
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.75883064
6vocalization behavior (GO:0071625)5.66741801
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.62689684
8regulation of glutamate receptor signaling pathway (GO:1900449)5.60767101
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55078474
10regulation of neuronal synaptic plasticity (GO:0048168)5.53518872
11regulation of synapse structural plasticity (GO:0051823)5.32727449
12synaptic vesicle exocytosis (GO:0016079)5.30378135
13glutamate secretion (GO:0014047)5.27301611
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.23862743
15exploration behavior (GO:0035640)5.07504900
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.89652904
17regulation of synaptic vesicle exocytosis (GO:2000300)4.85937962
18dendritic spine morphogenesis (GO:0060997)4.82418309
19protein localization to synapse (GO:0035418)4.76954879
20neurotransmitter-gated ion channel clustering (GO:0072578)4.56268314
21long-term memory (GO:0007616)4.53191068
22neuronal action potential propagation (GO:0019227)4.50950549
23regulation of synaptic vesicle transport (GO:1902803)4.46397884
24regulation of dendritic spine morphogenesis (GO:0061001)4.45141395
25synaptic transmission, glutamatergic (GO:0035249)4.43322036
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37551379
27positive regulation of membrane potential (GO:0045838)4.34971784
28neurotransmitter secretion (GO:0007269)4.33092115
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.31812373
30amino acid import (GO:0043090)4.31081720
31cerebellar granule cell differentiation (GO:0021707)4.27200862
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.25895042
33regulation of synaptic plasticity (GO:0048167)4.23111931
34potassium ion import (GO:0010107)4.09414675
35glutamate receptor signaling pathway (GO:0007215)4.09132378
36G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.07062991
37layer formation in cerebral cortex (GO:0021819)4.03445433
38neuromuscular process controlling balance (GO:0050885)4.01758388
39neuron-neuron synaptic transmission (GO:0007270)4.00041292
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.96732573
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.96283066
42negative regulation of dendrite morphogenesis (GO:0050774)3.96126563
43dendritic spine organization (GO:0097061)3.93759324
44regulation of postsynaptic membrane potential (GO:0060078)3.91165571
45neuromuscular synaptic transmission (GO:0007274)3.90101428
46potassium ion homeostasis (GO:0055075)3.84923719
47regulation of synapse maturation (GO:0090128)3.83124329
48positive regulation of synapse maturation (GO:0090129)3.73977074
49cellular potassium ion homeostasis (GO:0030007)3.71886050
50activation of protein kinase A activity (GO:0034199)3.70831759
51proline transport (GO:0015824)3.67491920
52postsynaptic membrane organization (GO:0001941)3.67081843
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.66597644
54long-term synaptic potentiation (GO:0060291)3.66133219
55sodium ion export (GO:0071436)3.65750991
56L-amino acid import (GO:0043092)3.65212779
57central nervous system myelination (GO:0022010)3.65037582
58axon ensheathment in central nervous system (GO:0032291)3.65037582
59auditory behavior (GO:0031223)3.58385858
60regulation of dendritic spine development (GO:0060998)3.57538415
61prepulse inhibition (GO:0060134)3.57493467
62regulation of ARF protein signal transduction (GO:0032012)3.55661752
63positive regulation of neurotransmitter secretion (GO:0001956)3.55632784
64positive regulation of dendritic spine development (GO:0060999)3.55326354
65neuron cell-cell adhesion (GO:0007158)3.53131690
66positive regulation of neurotransmitter transport (GO:0051590)3.52911788
67cerebellar Purkinje cell differentiation (GO:0021702)3.52567707
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.52050824
69regulation of cell communication by electrical coupling (GO:0010649)3.48389936
70regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.48016509
71neuronal ion channel clustering (GO:0045161)3.46080033
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.45782329
73transmission of nerve impulse (GO:0019226)3.42249867
74gamma-aminobutyric acid transport (GO:0015812)3.41539840
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.39375875
76regulation of neurotransmitter secretion (GO:0046928)3.38087819
77neurotransmitter transport (GO:0006836)3.36129350
78cytoskeletal anchoring at plasma membrane (GO:0007016)3.35084939
79chemosensory behavior (GO:0007635)3.34263360
80behavioral fear response (GO:0001662)3.33599580
81behavioral defense response (GO:0002209)3.33599580
82response to auditory stimulus (GO:0010996)3.33325132
83synaptic vesicle endocytosis (GO:0048488)3.28660567
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28352467
85regulation of female receptivity (GO:0045924)3.27834985
86regulation of vesicle fusion (GO:0031338)3.25596617
87membrane depolarization (GO:0051899)3.24456983
88regulation of neurotransmitter levels (GO:0001505)3.22856436
89cellular sodium ion homeostasis (GO:0006883)3.21110579
90positive regulation of synaptic transmission (GO:0050806)3.20919198
91learning (GO:0007612)3.20265055
92regulation of neurotransmitter transport (GO:0051588)3.20231444
93cell communication by electrical coupling (GO:0010644)3.18636083
94acidic amino acid transport (GO:0015800)3.18559592
95gamma-aminobutyric acid signaling pathway (GO:0007214)3.18304608
96regulation of synaptic transmission (GO:0050804)3.17304908
97innervation (GO:0060384)3.12226216
98positive regulation of dendrite development (GO:1900006)3.11650906
99neuromuscular process controlling posture (GO:0050884)3.09502526
100regulation of oxidative phosphorylation (GO:0002082)3.09075868
101signal complex assembly (GO:0007172)3.08955820
102regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.08724703
103neurotransmitter uptake (GO:0001504)3.08593165
104neuromuscular process (GO:0050905)3.08433069
105vesicle docking involved in exocytosis (GO:0006904)3.07800979
106vesicle transport along microtubule (GO:0047496)3.07457303
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06652518
108positive regulation of fibroblast migration (GO:0010763)3.05985277
109neuron recognition (GO:0008038)3.04620509
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03102505
111dendrite morphogenesis (GO:0048813)3.02669714
112visual learning (GO:0008542)3.01240587
113glycine transport (GO:0015816)3.01182776
114positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.00641735
115fear response (GO:0042596)3.00128749
116membrane depolarization during action potential (GO:0086010)2.99293428
117membrane hyperpolarization (GO:0060081)2.97336636
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96025209
119regulation of voltage-gated calcium channel activity (GO:1901385)2.95457320
120intraspecies interaction between organisms (GO:0051703)2.95146692
121social behavior (GO:0035176)2.95146692
122long term synaptic depression (GO:0060292)2.93788718
123detection of calcium ion (GO:0005513)2.93019753
124positive regulation of vesicle fusion (GO:0031340)2.92449850
125synaptic transmission (GO:0007268)2.92309244
126phosphorelay signal transduction system (GO:0000160)2.90721855
127regulation of exocytosis (GO:0017157)2.90643140
128regulation of dendrite morphogenesis (GO:0048814)2.88309473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99990382
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.37150378
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18173803
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13652111
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12442538
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89009440
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89009440
8DROSHA_22980978_ChIP-Seq_HELA_Human2.85956186
9REST_21632747_ChIP-Seq_MESCs_Mouse2.83714735
10GBX2_23144817_ChIP-Seq_PC3_Human2.82947365
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76135624
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70455768
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65766052
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64770648
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63826804
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50905738
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47547415
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43022130
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39289491
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.38079132
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.37747238
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32990780
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32024773
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28153748
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.13050049
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.89424049
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84432663
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78817499
29AR_21572438_ChIP-Seq_LNCaP_Human1.72516260
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64966365
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55579857
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48669705
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48582587
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48100051
35KDM2B_26808549_Chip-Seq_K562_Human1.44970780
36* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42455792
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40933898
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40427052
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36951780
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.36448832
41SMAD4_21799915_ChIP-Seq_A2780_Human1.36296850
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36254743
43GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33897387
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33165596
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27357559
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26291393
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26262503
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25176970
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23112399
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22208908
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.20227702
52AR_19668381_ChIP-Seq_PC3_Human1.19579434
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19286079
54OCT4_19829295_ChIP-Seq_ESCs_Human1.18560545
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18101560
56* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17400822
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16310648
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15851877
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11415953
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09870898
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.08630929
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07516279
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07378014
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06883091
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06691533
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06615995
67AR_25329375_ChIP-Seq_VCAP_Human1.05729374
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05005913
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.04603740
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04455989
71ZNF274_21170338_ChIP-Seq_K562_Hela1.04400062
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03841502
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03609334
74CTCF_27219007_Chip-Seq_Bcells_Human1.02702725
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02479971
76P68_20966046_ChIP-Seq_HELA_Human1.02247499
77* KDM2B_26808549_Chip-Seq_DND41_Human1.01465202
78STAT3_23295773_ChIP-Seq_U87_Human1.01389680
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99019456
80SMAD_19615063_ChIP-ChIP_OVARY_Human0.98837966
81RXR_22108803_ChIP-Seq_LS180_Human0.98403387
82DPY_21335234_ChIP-Seq_ESCs_Mouse0.98050630
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98032342
84* CREB1_26743006_Chip-Seq_LNCaP_Human0.96994191
85YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94923043
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94458208
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94317187
88P300_19829295_ChIP-Seq_ESCs_Human0.94166531
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93370733
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92290941
91* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92258593
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92121360
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.91559173
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.90142592
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.90029303
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.89290493
97KLF4_19829295_ChIP-Seq_ESCs_Human0.88457700
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.88448160
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88303963
100TCF4_23295773_ChIP-Seq_U87_Human0.88202243
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87757121
102TP53_16413492_ChIP-PET_HCT116_Human0.87054674
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87021782
104* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87002729
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86783063
106AHR_22903824_ChIP-Seq_MCF-7_Human0.86262358
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.85978634
108TAF15_26573619_Chip-Seq_HEK293_Human0.85082710
109LXR_22292898_ChIP-Seq_THP-1_Human0.84875604
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84785037
111* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84699125
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82458544
113EGR1_19032775_ChIP-ChIP_M12_Human0.82369053
114SMAD4_21741376_ChIP-Seq_ESCs_Human0.82029352
115SMC4_20622854_ChIP-Seq_HELA_Human0.81947173
116* TET1_21451524_ChIP-Seq_MESCs_Mouse0.81260786
117* SA1_27219007_Chip-Seq_Bcells_Human0.80488845
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80436275
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80269411
120* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80187707
121MYC_19915707_ChIP-ChIP_AK7_Human0.80095055
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79934811
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79447146
124SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.79306756
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78738429
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.77951456
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77946265
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.77864309
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76215246
130RNF2_27304074_Chip-Seq_NSC_Mouse0.76097881
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.75232275
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73379310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.62325587
2MP0003880_abnormal_central_pattern4.74919842
3MP0003635_abnormal_synaptic_transmissio4.56297498
4MP0002822_catalepsy4.49820982
5MP0004270_analgesia3.87465755
6MP0002063_abnormal_learning/memory/cond3.76362968
7MP0009745_abnormal_behavioral_response3.70402612
8MP0002064_seizures3.29955492
9MP0002572_abnormal_emotion/affect_behav2.87707011
10MP0001968_abnormal_touch/_nociception2.69833727
11MP0001486_abnormal_startle_reflex2.67861727
12MP0009046_muscle_twitch2.64120640
13MP0002272_abnormal_nervous_system2.56508979
14MP0005423_abnormal_somatic_nervous2.40354711
15MP0002734_abnormal_mechanical_nocicepti2.37894052
16MP0001501_abnormal_sleep_pattern2.24278390
17MP0009780_abnormal_chondrocyte_physiolo2.21390264
18MP0000749_muscle_degeneration2.06128801
19MP0008569_lethality_at_weaning1.95871620
20MP0002736_abnormal_nociception_after1.95093877
21MP0002735_abnormal_chemical_nociception1.94705267
22MP0004858_abnormal_nervous_system1.94533014
23MP0004811_abnormal_neuron_physiology1.91433251
24MP0001440_abnormal_grooming_behavior1.91357558
25MP0002909_abnormal_adrenal_gland1.90610223
26MP0003075_altered_response_to1.78899543
27MP0001970_abnormal_pain_threshold1.78868654
28MP0003329_amyloid_beta_deposits1.75936099
29MP0004145_abnormal_muscle_electrophysio1.72195040
30MP0002733_abnormal_thermal_nociception1.69189922
31MP0005646_abnormal_pituitary_gland1.64985185
32MP0003879_abnormal_hair_cell1.64239716
33MP0002557_abnormal_social/conspecific_i1.61230660
34MP0004885_abnormal_endolymph1.58091753
35MP0002067_abnormal_sensory_capabilities1.56513521
36MP0004924_abnormal_behavior1.51445268
37MP0005386_behavior/neurological_phenoty1.51445268
38MP0003633_abnormal_nervous_system1.50359463
39MP0000955_abnormal_spinal_cord1.43254082
40MP0000778_abnormal_nervous_system1.42816706
41MP0002184_abnormal_innervation1.42681264
42MP0002066_abnormal_motor_capabilities/c1.37004207
43MP0002882_abnormal_neuron_morphology1.31193589
44MP0003787_abnormal_imprinting1.29039030
45MP0003123_paternal_imprinting1.27172980
46MP0003631_nervous_system_phenotype1.20670381
47MP0010234_abnormal_vibrissa_follicle1.18835583
48MP0005167_abnormal_blood-brain_barrier1.17645150
49MP0000747_muscle_weakness1.16078013
50MP0001177_atelectasis1.15554096
51MP0004036_abnormal_muscle_relaxation1.14531771
52MP0001905_abnormal_dopamine_level1.13957304
53MP0001529_abnormal_vocalization1.13625960
54MP0001984_abnormal_olfaction1.12501342
55MP0008874_decreased_physiological_sensi1.11814904
56MP0008872_abnormal_physiological_respon1.07889314
57MP0008961_abnormal_basal_metabolism1.04304857
58MP0003690_abnormal_glial_cell1.02782544
59MP0002152_abnormal_brain_morphology1.01697737
60MP0003283_abnormal_digestive_organ1.00615475
61MP0001502_abnormal_circadian_rhythm0.99480219
62MP0004510_myositis0.98772019
63MP0002069_abnormal_eating/drinking_beha0.96583697
64MP0003646_muscle_fatigue0.94198024
65MP0000759_abnormal_skeletal_muscle0.94089275
66MP0005535_abnormal_body_temperature0.92064828
67MP0005645_abnormal_hypothalamus_physiol0.90861572
68MP0000920_abnormal_myelination0.88173848
69MP0004147_increased_porphyrin_level0.88141675
70MP0000751_myopathy0.87685793
71MP0000569_abnormal_digit_pigmentation0.86485159
72MP0002090_abnormal_vision0.85558024
73MP0002638_abnormal_pupillary_reflex0.83513124
74MP0000604_amyloidosis0.82591401
75MP0002269_muscular_atrophy0.82521816
76MP0004087_abnormal_muscle_fiber0.82357428
77MP0004142_abnormal_muscle_tone0.81926857
78MP0002837_dystrophic_cardiac_calcinosis0.81686889
79MP0004085_abnormal_heartbeat0.81370695
80MP0000013_abnormal_adipose_tissue0.78193766
81MP0005409_darkened_coat_color0.77726641
82MP0005620_abnormal_muscle_contractility0.77646710
83MP0002229_neurodegeneration0.76584490
84MP0002106_abnormal_muscle_physiology0.75284953
85MP0005166_decreased_susceptibility_to0.75276776
86MP0003634_abnormal_glial_cell0.75084094
87MP0001986_abnormal_taste_sensitivity0.72855795
88MP0003632_abnormal_nervous_system0.72675794
89MP0006276_abnormal_autonomic_nervous0.70765956
90MP0004084_abnormal_cardiac_muscle0.68276658
91MP0005369_muscle_phenotype0.68019785
92MP0006036_abnormal_mitochondrial_physio0.67750018
93MP0005623_abnormal_meninges_morphology0.66440603
94MP0010386_abnormal_urinary_bladder0.65460750
95MP0003172_abnormal_lysosome_physiology0.65246176
96MP0001963_abnormal_hearing_physiology0.64367185
97MP0005394_taste/olfaction_phenotype0.63743775
98MP0005499_abnormal_olfactory_system0.63743775
99MP0004484_altered_response_of0.63075605
100MP0001188_hyperpigmentation0.61639886
101MP0001664_abnormal_digestion0.61629823
102MP0004130_abnormal_muscle_cell0.60186061
103MP0003137_abnormal_impulse_conducting0.58359440
104MP0005330_cardiomyopathy0.57252562
105MP0004043_abnormal_pH_regulation0.56788924
106MP0003122_maternal_imprinting0.54876934
107MP0005551_abnormal_eye_electrophysiolog0.53083236
108MP0004215_abnormal_myocardial_fiber0.52971094
109MP0001348_abnormal_lacrimal_gland0.52519944
110MP0003183_abnormal_peptide_metabolism0.52077673
111MP0001765_abnormal_ion_homeostasis0.52039555
112MP0001485_abnormal_pinna_reflex0.51754660
113MP0002332_abnormal_exercise_endurance0.48889380
114MP0002752_abnormal_somatic_nervous0.47899680
115MP0001346_abnormal_lacrimal_gland0.47580763
116MP0000631_abnormal_neuroendocrine_gland0.47419484
117MP0004233_abnormal_muscle_weight0.47058994
118MP0002234_abnormal_pharynx_morphology0.47023573
119MP0003956_abnormal_body_size0.46942298
120MP0004742_abnormal_vestibular_system0.46563003
121MP0010769_abnormal_survival0.45572292
122MP0001943_abnormal_respiration0.44883716

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.39882257
2Focal motor seizures (HP:0011153)8.20694563
3Focal seizures (HP:0007359)5.87565791
4Visual hallucinations (HP:0002367)5.35149492
5Action tremor (HP:0002345)4.53372924
6Epileptic encephalopathy (HP:0200134)4.31947645
7Impaired vibration sensation in the lower limbs (HP:0002166)4.15470929
8Febrile seizures (HP:0002373)4.14963831
9Atonic seizures (HP:0010819)4.08494135
10Muscle fiber inclusion bodies (HP:0100299)4.04106488
11Exercise-induced myalgia (HP:0003738)4.00797015
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.98007695
13Progressive cerebellar ataxia (HP:0002073)3.97839239
14Absence seizures (HP:0002121)3.88033942
15Generalized tonic-clonic seizures (HP:0002069)3.87192015
16Annular pancreas (HP:0001734)3.79148266
17Ankle clonus (HP:0011448)3.78127217
18Depression (HP:0000716)3.74601084
19Poor eye contact (HP:0000817)3.66768314
20Abnormality of the lower motor neuron (HP:0002366)3.65041649
21Dialeptic seizures (HP:0011146)3.61479381
22Nemaline bodies (HP:0003798)3.59695808
23Hyporeflexia of lower limbs (HP:0002600)3.54397869
24Papilledema (HP:0001085)3.53579305
25Exercise-induced muscle cramps (HP:0003710)3.46898380
26Dysmetria (HP:0001310)3.44565675
27Anxiety (HP:0000739)3.41117134
28Supranuclear gaze palsy (HP:0000605)3.40272151
29Postural instability (HP:0002172)3.40230629
30Broad-based gait (HP:0002136)3.34857092
31Dysdiadochokinesis (HP:0002075)3.34690204
32Gaze-evoked nystagmus (HP:0000640)3.34224571
33Torticollis (HP:0000473)3.31888293
34Cerebral hypomyelination (HP:0006808)3.31240042
35Impaired social interactions (HP:0000735)3.29582127
36Abnormal social behavior (HP:0012433)3.29582127
37Urinary bladder sphincter dysfunction (HP:0002839)3.26520211
38Focal dystonia (HP:0004373)3.23347927
39Tetraplegia (HP:0002445)3.13679767
40Ventricular fibrillation (HP:0001663)3.05468601
41Amblyopia (HP:0000646)3.04310695
42Urinary urgency (HP:0000012)3.01581758
43EMG: myopathic abnormalities (HP:0003458)2.98432280
44Intention tremor (HP:0002080)2.97040790
45Abnormal eating behavior (HP:0100738)2.91949925
46Stereotypic behavior (HP:0000733)2.91371946
47Mutism (HP:0002300)2.87041026
48Megalencephaly (HP:0001355)2.86830322
49Akinesia (HP:0002304)2.85416742
50Impaired vibratory sensation (HP:0002495)2.84254855
51Truncal ataxia (HP:0002078)2.79864750
52Impaired smooth pursuit (HP:0007772)2.79783134
53Myopathic facies (HP:0002058)2.79368457
54Pointed chin (HP:0000307)2.78701386
55Limb dystonia (HP:0002451)2.77467696
56Bundle branch block (HP:0011710)2.77301762
57Craniofacial dystonia (HP:0012179)2.75658647
58Bradykinesia (HP:0002067)2.73323681
59Type 1 muscle fiber predominance (HP:0003803)2.72873866
60Spastic gait (HP:0002064)2.64993232
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.63705179
62Ankyloglossia (HP:0010296)2.61473386
63Hemiplegia (HP:0002301)2.59673947
64Sudden death (HP:0001699)2.57282108
65Resting tremor (HP:0002322)2.54146643
66Frequent falls (HP:0002359)2.52739875
67Muscle hypertrophy of the lower extremities (HP:0008968)2.50824839
68Scanning speech (HP:0002168)2.47083051
69Hyperventilation (HP:0002883)2.44406047
70Muscle fiber splitting (HP:0003555)2.43328738
71Foot dorsiflexor weakness (HP:0009027)2.42907741
72Abnormality of ocular smooth pursuit (HP:0000617)2.41744893
73Neurofibrillary tangles (HP:0002185)2.39183127
74Genetic anticipation (HP:0003743)2.38259320
75Cerebral inclusion bodies (HP:0100314)2.38191115
76Calf muscle hypertrophy (HP:0008981)2.35609350
77Dysmetric saccades (HP:0000641)2.34378594
78Abnormality of the foot musculature (HP:0001436)2.33794363
79Lower limb asymmetry (HP:0100559)2.31555561
80Distal arthrogryposis (HP:0005684)2.30761432
81Hemiparesis (HP:0001269)2.28841913
82Insomnia (HP:0100785)2.27559412
83Obstructive sleep apnea (HP:0002870)2.26723404
84Muscle stiffness (HP:0003552)2.26544911
85Progressive inability to walk (HP:0002505)2.21005825
86Incomplete penetrance (HP:0003829)2.19831461
87Difficulty running (HP:0009046)2.18617717
88Abnormality of the periventricular white matter (HP:0002518)2.17576019
89Scapular winging (HP:0003691)2.17349404
90Lower limb muscle weakness (HP:0007340)2.16960243
91Drooling (HP:0002307)2.16807735
92Excessive salivation (HP:0003781)2.16807735
93Abnormality of binocular vision (HP:0011514)2.16275181
94Diplopia (HP:0000651)2.16275181
95Abnormality of the calf musculature (HP:0001430)2.15743230
96Abnormal EKG (HP:0003115)2.12551417
97Diminished motivation (HP:0000745)2.11037388
98Epileptiform EEG discharges (HP:0011182)2.10301129
99Generalized myoclonic seizures (HP:0002123)2.08572814
100Fetal akinesia sequence (HP:0001989)2.08387408
101Insidious onset (HP:0003587)2.08128072
102Termporal pattern (HP:0011008)2.08128072
103Lower limb amyotrophy (HP:0007210)2.07333692
104Status epilepticus (HP:0002133)2.06398246
105Rapidly progressive (HP:0003678)2.05891932
106Abnormality of skeletal muscle fiber size (HP:0012084)2.04469926
107Peripheral hypomyelination (HP:0007182)2.03013635
108Clonus (HP:0002169)2.01837054
109EEG with generalized epileptiform discharges (HP:0011198)2.00386890
110Neck muscle weakness (HP:0000467)1.99810587
111Sleep apnea (HP:0010535)1.99060006
112Delusions (HP:0000746)1.98812246
113Gait ataxia (HP:0002066)1.98087483
114Rimmed vacuoles (HP:0003805)1.97889548
115Abnormal atrioventricular conduction (HP:0005150)1.97721997
116Increased variability in muscle fiber diameter (HP:0003557)1.97053057
117Hypsarrhythmia (HP:0002521)1.95543852
118Rigidity (HP:0002063)1.94042481
119Apathy (HP:0000741)1.93293874
120Polygenic inheritance (HP:0010982)1.90630917
121Spinal canal stenosis (HP:0003416)1.89478551
122Abnormality of saccadic eye movements (HP:0000570)1.88965036
123Abnormality of oral frenula (HP:0000190)1.87721005
124Anosmia (HP:0000458)1.86058740
125Achilles tendon contracture (HP:0001771)1.83134198
126Intellectual disability, profound (HP:0002187)1.79317876
127Absent speech (HP:0001344)1.78210422
128Spastic tetraparesis (HP:0001285)1.77532929
129Neuronal loss in central nervous system (HP:0002529)1.75958315
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74758957
131Heart block (HP:0012722)1.74286679
132Increased circulating renin level (HP:0000848)1.72042366
133Aplasia involving bones of the extremities (HP:0009825)1.70364913
134Aplasia of the phalanges of the hand (HP:0009802)1.70364913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.87834405
2NTRK34.61423917
3MAP3K93.99870190
4PRKD33.45453955
5DAPK22.95165665
6KSR22.93185939
7MINK12.63186405
8OBSCN2.60279702
9CAMKK12.31046008
10PAK62.28861549
11MAP3K42.19806142
12RIPK42.03358173
13MAP3K131.96468804
14ARAF1.91222587
15MARK11.90477416
16KSR11.82323309
17NTRK11.80220065
18PRPF4B1.79733007
19DAPK11.74003791
20NTRK21.73238695
21CDK51.63752725
22MAP2K71.61892509
23MAP3K21.57856843
24STK381.57055412
25FES1.56996285
26TYRO31.41824074
27MAP2K41.40778180
28MAPK121.37983192
29RAF11.29893898
30TAOK11.26106933
31MAP3K121.25360712
32CAMK11.21038085
33SIK21.18750666
34PTK2B1.17466464
35PRKCG1.13969844
36TNIK1.13472799
37GRK51.11052999
38PRKCH1.00448473
39PDK10.99373585
40PINK10.98639455
41PLK20.98517604
42CDK190.98238074
43ALK0.92392248
44UHMK10.91405500
45STK110.87956234
46CDK150.86439077
47CAMK2A0.86185686
48PDPK10.86080522
49CDK180.85743923
50LMTK20.84087622
51CAMK2B0.82197136
52SGK2230.82180402
53SGK4940.82180402
54MAP3K10.82019279
55MAP3K70.81520161
56CDK140.79352649
57RET0.78088929
58CCNB10.76177600
59CDK11A0.75535239
60MAPK130.73982030
61BMPR20.72434080
62SGK30.72431044
63MAP3K110.70385147
64NME10.70098089
65SGK10.69716001
66NEK10.69024383
67BRSK10.68883716
68CAMKK20.67484424
69SGK20.65596305
70CASK0.65464740
71LATS20.64981841
72MARK20.64567493
73PKN10.64394823
74CAMK40.63910247
75PAK30.63522362
76RIPK10.60961688
77DMPK0.59148386
78TNK20.57678911
79LIMK10.56358566
80NEK60.56109991
81TTN0.55556596
82MAP2K10.54862131
83PRKG20.54433148
84PHKG10.53735060
85PHKG20.53735060
86DAPK30.52447802
87MAP2K60.51704695
88RPS6KA30.51243460
89DYRK1A0.48902104
90DDR20.48691294
91FYN0.48274923
92PRKCZ0.46997162
93OXSR10.46310695
94MOS0.44557154
95MAPK100.43821439
96ROCK20.43653437
97ROCK10.43448880
98PRKD20.43339880
99PNCK0.43302278
100IRAK20.39184820
101TRIB30.38738112
102FGR0.38065371
103FER0.36858744
104BRAF0.34918200
105CAMK2G0.34878071
106CDC42BPA0.34602551
107AKT20.33421423
108CAMK2D0.33294165
109RPS6KB10.32557406
110PDGFRA0.32516557
111TAOK20.32050762
112PRKCE0.30406473
113PRKCA0.28882650
114BMX0.28626739
115PRKCB0.28401940
116SCYL20.28279875
117PRKG10.28195874
118TESK10.26615786
119MAPK40.24875877
120MAPK80.24474073
121ICK0.22377599

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.25103120
2Nicotine addiction_Homo sapiens_hsa050333.07387223
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94528492
4Long-term potentiation_Homo sapiens_hsa047202.90578477
5Circadian entrainment_Homo sapiens_hsa047132.79137918
6Amphetamine addiction_Homo sapiens_hsa050312.63569577
7Glutamatergic synapse_Homo sapiens_hsa047242.60872165
8GABAergic synapse_Homo sapiens_hsa047272.47364300
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42989144
10Morphine addiction_Homo sapiens_hsa050322.40669269
11Salivary secretion_Homo sapiens_hsa049702.24640698
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20411406
13Dopaminergic synapse_Homo sapiens_hsa047282.13525411
14Aldosterone synthesis and secretion_Homo sapiens_hsa049252.11564018
15Gastric acid secretion_Homo sapiens_hsa049712.09575915
16Nitrogen metabolism_Homo sapiens_hsa009102.09440683
17Cholinergic synapse_Homo sapiens_hsa047252.07655460
18Insulin secretion_Homo sapiens_hsa049112.04561860
19Oxytocin signaling pathway_Homo sapiens_hsa049211.79672298
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78757094
21Vitamin B6 metabolism_Homo sapiens_hsa007501.72723592
22Calcium signaling pathway_Homo sapiens_hsa040201.70256561
23GnRH signaling pathway_Homo sapiens_hsa049121.64393883
24Cocaine addiction_Homo sapiens_hsa050301.62911047
25Renin secretion_Homo sapiens_hsa049241.61814927
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58643906
27Long-term depression_Homo sapiens_hsa047301.53480375
28Glioma_Homo sapiens_hsa052141.46584514
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39669231
30Serotonergic synapse_Homo sapiens_hsa047261.35119519
31Gap junction_Homo sapiens_hsa045401.34911955
32cAMP signaling pathway_Homo sapiens_hsa040241.32627948
33Taste transduction_Homo sapiens_hsa047421.28590955
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22624569
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17784811
36Type II diabetes mellitus_Homo sapiens_hsa049301.17556028
37Estrogen signaling pathway_Homo sapiens_hsa049151.15317968
38Melanogenesis_Homo sapiens_hsa049161.11660250
39ErbB signaling pathway_Homo sapiens_hsa040121.10969065
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10463720
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09094726
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08632896
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.01926386
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.00060248
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98092568
46Oocyte meiosis_Homo sapiens_hsa041140.96085356
47Axon guidance_Homo sapiens_hsa043600.92945275
48Dorso-ventral axis formation_Homo sapiens_hsa043200.87482236
49VEGF signaling pathway_Homo sapiens_hsa043700.87094129
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86664886
51Collecting duct acid secretion_Homo sapiens_hsa049660.86346737
52Pancreatic secretion_Homo sapiens_hsa049720.86054379
53Thyroid hormone synthesis_Homo sapiens_hsa049180.83212235
54Choline metabolism in cancer_Homo sapiens_hsa052310.79765674
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75626304
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74631863
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.73447914
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72880437
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72679331
60Dilated cardiomyopathy_Homo sapiens_hsa054140.72585390
61Arginine and proline metabolism_Homo sapiens_hsa003300.71322965
62Rap1 signaling pathway_Homo sapiens_hsa040150.71207521
63Non-small cell lung cancer_Homo sapiens_hsa052230.70288094
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69265318
65Cardiac muscle contraction_Homo sapiens_hsa042600.68230205
66MAPK signaling pathway_Homo sapiens_hsa040100.66930142
67Glucagon signaling pathway_Homo sapiens_hsa049220.65270474
68mTOR signaling pathway_Homo sapiens_hsa041500.65053607
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64509104
70Endocytosis_Homo sapiens_hsa041440.62811289
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62521556
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.59820805
73Bile secretion_Homo sapiens_hsa049760.59226616
74Ras signaling pathway_Homo sapiens_hsa040140.58310150
75Vibrio cholerae infection_Homo sapiens_hsa051100.53551220
76Type I diabetes mellitus_Homo sapiens_hsa049400.53441513
77African trypanosomiasis_Homo sapiens_hsa051430.52262284
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49630062
79Prion diseases_Homo sapiens_hsa050200.49283200
80Phototransduction_Homo sapiens_hsa047440.48622415
81Inositol phosphate metabolism_Homo sapiens_hsa005620.48033643
82Alcoholism_Homo sapiens_hsa050340.47370386
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45548759
84Chemokine signaling pathway_Homo sapiens_hsa040620.45455034
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44736207
86Endometrial cancer_Homo sapiens_hsa052130.44721519
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44558609
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44310447
89AMPK signaling pathway_Homo sapiens_hsa041520.43126733
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42281125
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42074659
92Alzheimers disease_Homo sapiens_hsa050100.39743538
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38229942
94Arginine biosynthesis_Homo sapiens_hsa002200.38012824
95Mineral absorption_Homo sapiens_hsa049780.37820675
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37578228
97Renal cell carcinoma_Homo sapiens_hsa052110.36682157
98Wnt signaling pathway_Homo sapiens_hsa043100.36108244
99Insulin signaling pathway_Homo sapiens_hsa049100.36012098
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35160495
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35032030
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34749190
103Platelet activation_Homo sapiens_hsa046110.32372769
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30685231
105Tight junction_Homo sapiens_hsa045300.29888571
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29740579
107Ovarian steroidogenesis_Homo sapiens_hsa049130.29606515
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28722958
109HIF-1 signaling pathway_Homo sapiens_hsa040660.27575622
110Circadian rhythm_Homo sapiens_hsa047100.27385403
111beta-Alanine metabolism_Homo sapiens_hsa004100.23385566
112Histidine metabolism_Homo sapiens_hsa003400.22633377

Most similar genes based on co-expression Upload to Enrichr

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