DDOST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.37679536
2protein retention in ER lumen (GO:0006621)7.61185709
3signal peptide processing (GO:0006465)6.53769369
4protein maturation by protein folding (GO:0022417)6.45380993
5COPII vesicle coating (GO:0048208)5.99685903
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.83403048
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.43161440
8positive regulation of nuclease activity (GO:0032075)5.37423623
9sequestering of metal ion (GO:0051238)5.04864434
10regulation of nuclease activity (GO:0032069)4.92349638
11exocrine pancreas development (GO:0031017)4.74438041
12endoplasmic reticulum unfolded protein response (GO:0030968)4.69403940
13cellular response to unfolded protein (GO:0034620)4.56165776
14cellular response to topologically incorrect protein (GO:0035967)4.50927618
15folic acid-containing compound biosynthetic process (GO:0009396)4.48570633
16ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.44177891
17* protein N-linked glycosylation via asparagine (GO:0018279)4.28257018
18ER-nucleus signaling pathway (GO:0006984)4.26042593
19* peptidyl-asparagine modification (GO:0018196)4.24693828
20vesicle coating (GO:0006901)4.22689416
21* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.13298583
22endocrine pancreas development (GO:0031018)4.06821938
23* protein targeting to ER (GO:0045047)4.03088109
24* cotranslational protein targeting to membrane (GO:0006613)4.00936211
25peptide hormone processing (GO:0016486)3.98272763
26* protein N-linked glycosylation (GO:0006487)3.92545907
27protein autoprocessing (GO:0016540)3.90463300
28GDP-mannose metabolic process (GO:0019673)3.85434157
29* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.84524169
30proline biosynthetic process (GO:0006561)3.84400161
31* protein localization to endoplasmic reticulum (GO:0070972)3.80178448
32response to endoplasmic reticulum stress (GO:0034976)3.80092950
33establishment of integrated proviral latency (GO:0075713)3.76181911
34DNA deamination (GO:0045006)3.74833841
35glandular epithelial cell differentiation (GO:0002067)3.71657902
36pteridine-containing compound biosynthetic process (GO:0042559)3.71345447
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66938625
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66938625
39response to unfolded protein (GO:0006986)3.61022781
40negative regulation of glycoprotein biosynthetic process (GO:0010561)3.60705434
41response to topologically incorrect protein (GO:0035966)3.56953255
42peptidyl-arginine omega-N-methylation (GO:0035247)3.53534041
434-hydroxyproline metabolic process (GO:0019471)3.51573650
44regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.41599464
45ER to Golgi vesicle-mediated transport (GO:0006888)3.41474246
46establishment of viral latency (GO:0019043)3.40830950
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40344907
48ribosomal small subunit assembly (GO:0000028)3.39792275
49pinocytosis (GO:0006907)3.36434011
50nucleobase-containing small molecule interconversion (GO:0015949)3.32064782
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29686718
52negative regulation of ligase activity (GO:0051352)3.29686718
53UDP-N-acetylglucosamine metabolic process (GO:0006047)3.26710300
54regulation of type B pancreatic cell apoptotic process (GO:2000674)3.21613725
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18817226
56type B pancreatic cell development (GO:0003323)3.16067444
57cell redox homeostasis (GO:0045454)3.15321881
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10124292
59pentose-phosphate shunt (GO:0006098)3.09896953
60regulation of cellular amino acid metabolic process (GO:0006521)3.08687393
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08448042
62peptide catabolic process (GO:0043171)3.07060357
63chaperone-mediated protein folding (GO:0061077)3.05077612
64maintenance of protein localization in organelle (GO:0072595)3.04238804
65glandular epithelial cell development (GO:0002068)3.04201427
66proteasome assembly (GO:0043248)3.03939812
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03696324
68mitotic nuclear envelope reassembly (GO:0007084)3.00836545
69nuclear envelope reassembly (GO:0031468)3.00836545
70cellular response to vitamin D (GO:0071305)2.96510757
71maturation of SSU-rRNA (GO:0030490)2.96432700
72histone arginine methylation (GO:0034969)2.94315868
73L-alpha-amino acid transmembrane transport (GO:1902475)2.92184017
74maternal placenta development (GO:0001893)2.90258764
75tRNA aminoacylation for protein translation (GO:0006418)2.89881011
76response to misfolded protein (GO:0051788)2.89806067
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88197473
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88197473
79DNA strand elongation involved in DNA replication (GO:0006271)2.87890199
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87562580
81formation of translation preinitiation complex (GO:0001731)2.85489541
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85043699
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85043699
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85043699
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.83449089
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83449089
87regulation of mitochondrial translation (GO:0070129)2.82932203
88antigen processing and presentation of endogenous antigen (GO:0019883)2.81361589
89ribosomal large subunit biogenesis (GO:0042273)2.79634044
90positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.79369141
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78700016
92negative regulation of glycoprotein metabolic process (GO:1903019)2.77988047
93amino acid activation (GO:0043038)2.76538262
94tRNA aminoacylation (GO:0043039)2.76538262
95lipopolysaccharide biosynthetic process (GO:0009103)2.75480910
96regulation of translational termination (GO:0006449)2.75097676
97telomere maintenance via semi-conservative replication (GO:0032201)2.74435945
98ribosomal small subunit biogenesis (GO:0042274)2.73079553
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.72984284
100misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.72801306
101* protein targeting to membrane (GO:0006612)2.72534560
102NADPH regeneration (GO:0006740)2.72532453
103positive regulation of insulin secretion (GO:0032024)2.71671725
104regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71576519
105peptidyl-arginine methylation (GO:0018216)2.70363096
106peptidyl-arginine N-methylation (GO:0035246)2.70363096
107DNA strand elongation (GO:0022616)2.69707044
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69432576
109skin morphogenesis (GO:0043589)2.69054463
110ER overload response (GO:0006983)2.63719516
111amyloid precursor protein catabolic process (GO:0042987)2.62750764
112viral transcription (GO:0019083)2.60238647
113tricarboxylic acid metabolic process (GO:0072350)2.57654555
114peptidyl-proline hydroxylation (GO:0019511)2.57128735
115Golgi organization (GO:0007030)2.57104773
116positive regulation of ligase activity (GO:0051351)2.56827676
117ribosome assembly (GO:0042255)2.55664967
118regulation of ubiquitin-protein transferase activity (GO:0051438)2.54872661
119translational termination (GO:0006415)2.54672267
120pentose metabolic process (GO:0019321)2.54198861
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52015497
122IMP biosynthetic process (GO:0006188)2.51585457
123translational elongation (GO:0006414)2.50740130
124glucose catabolic process (GO:0006007)2.49964786
125tricarboxylic acid cycle (GO:0006099)2.49899179
126ribonucleoprotein complex biogenesis (GO:0022613)2.49761063
127protein hydroxylation (GO:0018126)2.48494712
128galactose catabolic process (GO:0019388)2.47904143
129antigen processing and presentation via MHC class Ib (GO:0002475)2.47399923
130glucose 6-phosphate metabolic process (GO:0051156)2.47249760
131nucleotide-sugar biosynthetic process (GO:0009226)2.47148693
132* translation (GO:0006412)2.46768400
133NADH metabolic process (GO:0006734)2.46686087
134antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.45124508
135nucleotide-sugar metabolic process (GO:0009225)2.45070735
136chaperone mediated protein folding requiring cofactor (GO:0051085)2.44947180
137protein peptidyl-prolyl isomerization (GO:0000413)2.44834593
138regulation of ligase activity (GO:0051340)2.44832976
139peptidyl-proline modification (GO:0018208)2.43932468
140DNA unwinding involved in DNA replication (GO:0006268)2.43673476
141hyaluronan catabolic process (GO:0030214)2.42749227
142positive regulation of receptor biosynthetic process (GO:0010870)2.42497322
143L-serine metabolic process (GO:0006563)2.40161656
144ribosome biogenesis (GO:0042254)2.39725737
145protein folding (GO:0006457)2.39692600
146proline metabolic process (GO:0006560)2.39257087
147basement membrane organization (GO:0071711)2.39224108
148keratan sulfate catabolic process (GO:0042340)2.38946972
149antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.38900269
150nucleobase biosynthetic process (GO:0046112)2.37899292
151regulation of translational fidelity (GO:0006450)2.37800437
152fucose metabolic process (GO:0006004)2.36167131
153tetrahydrofolate metabolic process (GO:0046653)2.35732801
154COPI coating of Golgi vesicle (GO:0048205)10.8882897
155Golgi transport vesicle coating (GO:0048200)10.8882897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.01525591
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92860316
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61276665
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.13005892
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75699743
6* GABP_17652178_ChIP-ChIP_JURKAT_Human2.68354317
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67764847
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46746729
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44678877
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.27702612
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26174275
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.24277790
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.18756965
14ZNF263_19887448_ChIP-Seq_K562_Human2.11293248
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11143305
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.07820985
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04479864
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03527920
19MYC_22102868_ChIP-Seq_BL_Human2.03337567
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03151348
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02868511
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95852530
23XRN2_22483619_ChIP-Seq_HELA_Human1.95506009
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94547271
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91381578
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90643269
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89681261
28* GABP_19822575_ChIP-Seq_HepG2_Human1.86290698
29DCP1A_22483619_ChIP-Seq_HELA_Human1.84917583
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82433290
31GATA1_22025678_ChIP-Seq_K562_Human1.77360012
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76920101
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76831565
34TFEB_21752829_ChIP-Seq_HELA_Human1.75860311
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71228158
36* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70696883
37VDR_23849224_ChIP-Seq_CD4+_Human1.69630666
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.67666962
39VDR_21846776_ChIP-Seq_THP-1_Human1.65226632
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64377645
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61329396
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60672560
43FOXP3_21729870_ChIP-Seq_TREG_Human1.58200681
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55338155
45CIITA_25753668_ChIP-Seq_RAJI_Human1.53345738
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53313100
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46349725
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44717788
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43942814
50CLOCK_20551151_ChIP-Seq_293T_Human1.43644474
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43628043
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40435548
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40334689
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39753648
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38816132
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37717269
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34539355
58TTF2_22483619_ChIP-Seq_HELA_Human1.34494354
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33104704
60AR_21909140_ChIP-Seq_LNCAP_Human1.31214920
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30963403
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30462978
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29940569
64* KDM5A_27292631_Chip-Seq_BREAST_Human1.29074040
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.27916545
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.27335141
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25398770
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25227154
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24976639
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.24606140
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24254762
72* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23754608
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23690231
74ELK1_19687146_ChIP-ChIP_HELA_Human1.22311003
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19784972
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15795992
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15321776
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15181635
79* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15071915
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14274190
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13817841
82* SPI1_23547873_ChIP-Seq_NB4_Human1.13375810
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12861252
84* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12492112
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10811769
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10746689
87* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10409482
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10220350
89ATF3_27146783_Chip-Seq_COLON_Human1.10099723
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08927864
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08292926
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08158750
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.08131399
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.08111660
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07243829
96* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07152682
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07003995
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.06546804
99* ELK1_22589737_ChIP-Seq_MCF10A_Human1.04605685
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04604357
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03525469
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02905656
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.02529181
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02007941
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01812256
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01379403
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01210588
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00969506
109VDR_24763502_ChIP-Seq_THP-1_Human1.00796272
110* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00633635
111* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99963169
112LXR_22292898_ChIP-Seq_THP-1_Human0.99616644
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99124103
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98666233
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98373870
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97745350
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97724626
118* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96775930
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96736855
120* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96283210
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96056084
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95925411
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95049629
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94333457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.70579399
2MP0006054_spinal_hemorrhage3.60758965
3MP0003283_abnormal_digestive_organ3.47873830
4MP0005220_abnormal_exocrine_pancreas3.14737670
5MP0003183_abnormal_peptide_metabolism2.78046386
6MP0001944_abnormal_pancreas_morphology2.71553215
7MP0003693_abnormal_embryo_hatching2.64565212
8MP0002693_abnormal_pancreas_physiology2.63880926
9MP0000013_abnormal_adipose_tissue2.57567326
10MP0010030_abnormal_orbit_morphology2.51567684
11MP0000678_abnormal_parathyroid_gland2.40793201
12MP0008438_abnormal_cutaneous_collagen2.39482955
13MP0003195_calcinosis2.36728844
14MP0004264_abnormal_extraembryonic_tissu2.24214333
15MP0002909_abnormal_adrenal_gland2.20290628
16MP0005058_abnormal_lysosome_morphology2.17745740
17MP0005451_abnormal_body_composition2.12732691
18MP0003300_gastrointestinal_ulcer2.04483524
19MP0004043_abnormal_pH_regulation1.98477961
20MP0003123_paternal_imprinting1.93092172
21MP0004957_abnormal_blastocyst_morpholog1.92707602
22MP0003172_abnormal_lysosome_physiology1.83032616
23MP0008260_abnormal_autophagy1.82781151
24MP0001849_ear_inflammation1.75996812
25MP0003941_abnormal_skin_development1.72243375
26MP0003191_abnormal_cellular_cholesterol1.61849191
27MP0005379_endocrine/exocrine_gland_phen1.61120120
28MP0010352_gastrointestinal_tract_polyps1.56299089
29MP0010234_abnormal_vibrissa_follicle1.49496290
30MP0009643_abnormal_urine_homeostasis1.48215398
31MP0000003_abnormal_adipose_tissue1.48078791
32MP0010386_abnormal_urinary_bladder1.44248078
33MP0009780_abnormal_chondrocyte_physiolo1.43260310
34MP0005501_abnormal_skin_physiology1.42679329
35MP0004233_abnormal_muscle_weight1.39347087
36MP0003566_abnormal_cell_adhesion1.38864705
37MP0000613_abnormal_salivary_gland1.35911303
38MP0000462_abnormal_digestive_system1.35865124
39MP0001661_extended_life_span1.34763725
40MP0002896_abnormal_bone_mineralization1.31485889
41MP0004858_abnormal_nervous_system1.30516646
42MP0001853_heart_inflammation1.26687044
43MP0000490_abnormal_crypts_of1.25350591
44MP0002078_abnormal_glucose_homeostasis1.24628313
45MP0002928_abnormal_bile_duct1.24486249
46MP0003786_premature_aging1.22885200
47MP0009697_abnormal_copulation1.22810531
48MP0003122_maternal_imprinting1.22402001
49MP0002796_impaired_skin_barrier1.21824543
50MP0003866_abnormal_defecation1.20368449
51MP0004782_abnormal_surfactant_physiolog1.19294499
52MP0001666_abnormal_nutrient_absorption1.17819629
53MP0003705_abnormal_hypodermis_morpholog1.17132590
54MP0005623_abnormal_meninges_morphology1.16536797
55MP0008007_abnormal_cellular_replicative1.15919227
56MP0009840_abnormal_foam_cell1.11185337
57MP0005380_embryogenesis_phenotype1.08922021
58MP0001672_abnormal_embryogenesis/_devel1.08922021
59MP0004272_abnormal_basement_membrane1.08716146
60MP0010368_abnormal_lymphatic_system1.08161586
61MP0005076_abnormal_cell_differentiation1.07705090
62MP0005165_increased_susceptibility_to1.07313592
63MP0005360_urolithiasis1.06739890
64MP0003077_abnormal_cell_cycle1.05808183
65MP0001915_intracranial_hemorrhage1.04205100
66MP0001881_abnormal_mammary_gland1.03573141
67MP0005083_abnormal_biliary_tract1.03431382
68MP0003984_embryonic_growth_retardation1.03141265
69MP0003959_abnormal_lean_body1.01440511
70MP0005257_abnormal_intraocular_pressure1.00996087
71MP0001216_abnormal_epidermal_layer1.00928211
72MP0001765_abnormal_ion_homeostasis1.00396545
73MP0000858_altered_metastatic_potential1.00289968
74MP0001756_abnormal_urination0.99446208
75MP0003315_abnormal_perineum_morphology0.99117862
76MP0003795_abnormal_bone_structure0.98224611
77MP0005330_cardiomyopathy0.97763233
78MP0005636_abnormal_mineral_homeostasis0.97620010
79MP0001730_embryonic_growth_arrest0.97492914
80MP0005197_abnormal_uvea_morphology0.95768333
81MP0002088_abnormal_embryonic_growth/wei0.95746411
82MP0000762_abnormal_tongue_morphology0.95070275
83MP0000358_abnormal_cell_content/0.94797349
84MP0003385_abnormal_body_wall0.94415684
85MP0001542_abnormal_bone_strength0.92974567
86MP0003453_abnormal_keratinocyte_physiol0.90590979
87MP0005023_abnormal_wound_healing0.89943055
88MP0003806_abnormal_nucleotide_metabolis0.89500464
89MP0002085_abnormal_embryonic_tissue0.89482457
90MP0002086_abnormal_extraembryonic_tissu0.89443492
91MP0002933_joint_inflammation0.87300278
92MP0009333_abnormal_splenocyte_physiolog0.87152649
93MP0008058_abnormal_DNA_repair0.86958686
94MP0003111_abnormal_nucleus_morphology0.86358265
95MP0000467_abnormal_esophagus_morphology0.86212622
96MP0001533_abnormal_skeleton_physiology0.85743418
97MP0005275_abnormal_skin_tensile0.85643746
98MP0002396_abnormal_hematopoietic_system0.84976896
99MP0009053_abnormal_anal_canal0.84669462
100MP0002080_prenatal_lethality0.83445490
101MP0005621_abnormal_cell_physiology0.83201531
102MP0003119_abnormal_digestive_system0.81897429
103MP0005408_hypopigmentation0.81840422
104MP0005365_abnormal_bile_salt0.81480956
105MP0000681_abnormal_thyroid_gland0.81459445
106MP0010307_abnormal_tumor_latency0.81291400
107MP0000627_abnormal_mammary_gland0.81108759
108MP0009384_cardiac_valve_regurgitation0.79789079
109MP0005084_abnormal_gallbladder_morpholo0.79706857
110MP0000343_altered_response_to0.79524352
111MP0009672_abnormal_birth_weight0.77757042
112MP0002089_abnormal_postnatal_growth/wei0.77423580
113MP0006035_abnormal_mitochondrial_morpho0.76522219
114MP0002084_abnormal_developmental_patter0.74283321
115MP0000477_abnormal_intestine_morphology0.73660719
116MP0000751_myopathy0.73388803
117MP0009931_abnormal_skin_appearance0.73111502
118MP0002098_abnormal_vibrissa_morphology0.73072817
119MP0005193_abnormal_anterior_eye0.73040491
120MP0000598_abnormal_liver_morphology0.72779700
121MP0003448_altered_tumor_morphology0.72537458
122MP0000537_abnormal_urethra_morphology0.72164258
123MP0008932_abnormal_embryonic_tissue0.72129117
124MP0001270_distended_abdomen0.71952831
125MP0003186_abnormal_redox_activity0.71543842
126MP0000350_abnormal_cell_proliferation0.71238322
127MP0003868_abnormal_feces_composition0.70578330
128MP0001697_abnormal_embryo_size0.70406086
129MP0010771_integument_phenotype0.70346295
130MP0003436_decreased_susceptibility_to0.69467809
131MP0001727_abnormal_embryo_implantation0.66920453
132MP0002234_abnormal_pharynx_morphology0.66738488
133MP0003953_abnormal_hormone_level0.66352759
134MP0002166_altered_tumor_susceptibility0.66150986
135MP0002295_abnormal_pulmonary_circulatio0.66093583
136MP0004808_abnormal_hematopoietic_stem0.65924441
137MP0005503_abnormal_tendon_morphology0.65895404
138MP0002111_abnormal_tail_morphology0.65868557
139MP0001845_abnormal_inflammatory_respons0.65851500
140MP0001243_abnormal_dermal_layer0.65281063
141MP0000163_abnormal_cartilage_morphology0.64961301
142MP0000465_gastrointestinal_hemorrhage0.64313957
143MP0010094_abnormal_chromosome_stability0.63551944
144MP0000639_abnormal_adrenal_gland0.62800951
145MP0000313_abnormal_cell_death0.62224603
146MP0005390_skeleton_phenotype0.61566954
147MP0002970_abnormal_white_adipose0.59940173
148MP0005384_cellular_phenotype0.59922187
149MP0003279_aneurysm0.59174110
150MP0005508_abnormal_skeleton_morphology0.58955542
151MP0004197_abnormal_fetal_growth/weight/0.58869394
152MP0002019_abnormal_tumor_incidence0.58759553
153MP0002135_abnormal_kidney_morphology0.58523625
154MP0002060_abnormal_skin_morphology0.58309825

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.22021534
2Hyperinsulinemic hypoglycemia (HP:0000825)5.07439373
3Hypoglycemic seizures (HP:0002173)4.92342520
4Symptomatic seizures (HP:0011145)4.22719691
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.10239280
6Urinary glycosaminoglycan excretion (HP:0003541)4.04409977
7Mucopolysacchariduria (HP:0008155)4.04409977
8Dysostosis multiplex (HP:0000943)3.98690609
9Abnormality of endocrine pancreas physiology (HP:0012093)3.79988209
10Abnormality of the pancreatic islet cells (HP:0006476)3.79988209
11Late onset (HP:0003584)3.73426660
12Abnormality of polysaccharide metabolism (HP:0011012)3.57608338
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.57608338
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.57608338
15Vacuolated lymphocytes (HP:0001922)3.42956929
16Abnormal gallbladder physiology (HP:0012438)3.31967447
17Cholecystitis (HP:0001082)3.31967447
1811 pairs of ribs (HP:0000878)3.26044587
19Generalized aminoaciduria (HP:0002909)3.22912010
20Cervical subluxation (HP:0003308)3.17023392
21Pancreatic islet-cell hyperplasia (HP:0004510)3.14622233
22Ketoacidosis (HP:0001993)3.10215855
23Microvesicular hepatic steatosis (HP:0001414)3.09331907
24Abnormality of the intrinsic pathway (HP:0010989)3.07972063
25Thoracolumbar scoliosis (HP:0002944)3.01149146
26Trismus (HP:0000211)2.95515696
27Abnormal pancreas size (HP:0012094)2.88047174
28Large for gestational age (HP:0001520)2.87438598
29Beaking of vertebral bodies (HP:0004568)2.82005192
30Thrombocytosis (HP:0001894)2.81454186
31Missing ribs (HP:0000921)2.78842477
32Hyperglycemia (HP:0003074)2.78769273
33Short nail (HP:0001799)2.77811672
34Abnormality of dentin (HP:0010299)2.75808326
35Hyperparathyroidism (HP:0000843)2.66970644
36Insulin resistance (HP:0000855)2.62562382
37Abnormality of glycolysis (HP:0004366)2.56678259
38Protrusio acetabuli (HP:0003179)2.55611401
39Aplastic anemia (HP:0001915)2.55070489
40Rough bone trabeculation (HP:0100670)2.53869988
41Abnormality of calcium-phosphate metabolism (HP:0100530)2.52861708
42Degeneration of anterior horn cells (HP:0002398)2.49455495
43Abnormality of the anterior horn cell (HP:0006802)2.49455495
44Insulin-resistant diabetes mellitus (HP:0000831)2.46123119
45Progressive neurologic deterioration (HP:0002344)2.38357774
46Reduced antithrombin III activity (HP:0001976)2.36513156
47Selective tooth agenesis (HP:0001592)2.31495912
48Joint stiffness (HP:0001387)2.27881136
49Atrophic scars (HP:0001075)2.26413994
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.26322612
51Osteolytic defects of the hand bones (HP:0009699)2.26322612
52Abnormality of the umbilical cord (HP:0010881)2.23389274
53Increased serum pyruvate (HP:0003542)2.22248181
54* Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22101628
55* Abnormal protein N-linked glycosylation (HP:0012347)2.22101628
56* Abnormal protein glycosylation (HP:0012346)2.22101628
57* Abnormal glycosylation (HP:0012345)2.22101628
58Poor head control (HP:0002421)2.21143851
59Severe short stature (HP:0003510)2.20441226
60Fragile skin (HP:0001030)2.18660034
61Abdominal distention (HP:0003270)2.16879548
62Achilles tendon contracture (HP:0001771)2.16484279
63Hand muscle atrophy (HP:0009130)2.13422357
64Ragged-red muscle fibers (HP:0003200)2.13020775
65Premature skin wrinkling (HP:0100678)2.11643141
66Abnormal number of erythroid precursors (HP:0012131)2.10165150
67Breech presentation (HP:0001623)2.09431468
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09411538
69Hypokinesia (HP:0002375)2.08460773
70Abnormal delivery (HP:0001787)2.08454479
71Entropion (HP:0000621)2.07016148
72Progressive muscle weakness (HP:0003323)2.06792394
73Blue sclerae (HP:0000592)2.06741502
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06310291
75Unilateral renal agenesis (HP:0000122)2.05549301
76Ulnar bowing (HP:0003031)2.04065900
77Biconcave vertebral bodies (HP:0004586)2.02207908
78Orthostatic hypotension (HP:0001278)1.99759677
79Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99042031
80Abnormality of cells of the erythroid lineage (HP:0012130)1.97702877
81Elbow flexion contracture (HP:0002987)1.97303544
82Platyspondyly (HP:0000926)1.97003425
83Wormian bones (HP:0002645)1.96878257
84Nonimmune hydrops fetalis (HP:0001790)1.96309844
85Upper limb amyotrophy (HP:0009129)1.96251458
86Distal upper limb amyotrophy (HP:0007149)1.96251458
87Abnormality of the Achilles tendon (HP:0005109)1.95485223
88Broad face (HP:0000283)1.95211702
89Abnormality of carpal bone ossification (HP:0006257)1.95016646
90Abnormal trabecular bone morphology (HP:0100671)1.94406069
91Abnormality of the distal phalanges of the toes (HP:0010182)1.93791188
92Sparse eyelashes (HP:0000653)1.93645155
93Ketosis (HP:0001946)1.92525258
94Abnormality of the common coagulation pathway (HP:0010990)1.92456705
95Spinal rigidity (HP:0003306)1.92195427
96Generalized amyotrophy (HP:0003700)1.91141811
97Retinal atrophy (HP:0001105)1.90265405
98Microretrognathia (HP:0000308)1.89985933
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.89604196
100Delayed cranial suture closure (HP:0000270)1.88377344
101Increased cerebral lipofuscin (HP:0011813)1.88310304
102Microglossia (HP:0000171)1.87955348
103Abnormalities of placenta or umbilical cord (HP:0001194)1.87939874
104Hypoplasia of the pons (HP:0012110)1.87248698
105Aortic dissection (HP:0002647)1.86820920
106Abnormality of the calcaneus (HP:0008364)1.86221119
107Vertebral compression fractures (HP:0002953)1.86177130
108Bladder diverticulum (HP:0000015)1.85733309
109Prominent metopic ridge (HP:0005487)1.84672411
110Abnormality of T cell physiology (HP:0011840)1.83375101
111Exocrine pancreatic insufficiency (HP:0001738)1.80581630
112Cerebral aneurysm (HP:0004944)1.79811592
113Premature rupture of membranes (HP:0001788)1.79783557
114Abnormality of oral frenula (HP:0000190)1.79186162
115Slender long bone (HP:0003100)1.78986967
116Hyperacusis (HP:0010780)1.78969453
117Hepatosplenomegaly (HP:0001433)1.78328240
118Back pain (HP:0003418)1.78215838
119Testicular atrophy (HP:0000029)1.78210454
120Disproportionate short-trunk short stature (HP:0003521)1.75178141
121Metaphyseal cupping (HP:0003021)1.75141856
122Deep venous thrombosis (HP:0002625)1.75091287
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.74973984
124Abnormality of glycolipid metabolism (HP:0010969)1.74973984
125Abnormality of liposaccharide metabolism (HP:0010968)1.74973984
126Multiple enchondromatosis (HP:0005701)1.73660496
127Thin bony cortex (HP:0002753)1.72898112
128Abnormality of the fetal cardiovascular system (HP:0010948)1.72657575
129Abnormal umbilical cord blood vessels (HP:0011403)1.72657575
130Single umbilical artery (HP:0001195)1.72657575
131Natal tooth (HP:0000695)1.72646681
132Deviation of the thumb (HP:0009603)1.72024989
133Congenital glaucoma (HP:0001087)1.71891042
134Hypoplasia of the odontoid process (HP:0003311)1.71569380
135Spastic diplegia (HP:0001264)1.70614922
136Reticulocytopenia (HP:0001896)1.70468426
137Pterygium (HP:0001059)1.70374609
138J-shaped sella turcica (HP:0002680)1.68281429
139Flattened epiphyses (HP:0003071)1.68266952
140Decreased circulating renin level (HP:0003351)1.67045659
141Hypokalemia (HP:0002900)1.66762122
142Death in infancy (HP:0001522)1.66609285
143Dysautonomia (HP:0002459)1.66331091
144Hypertensive crisis (HP:0100735)1.65799870
145Fasciculations (HP:0002380)1.65536755
146Hyperphosphatemia (HP:0002905)1.65277511
147Small epiphyses (HP:0010585)1.65023932
148Flat acetabular roof (HP:0003180)1.64755094
149Pili torti (HP:0003777)1.64511065
150Ulnar deviation of the wrist (HP:0003049)1.63655797
151Hypercortisolism (HP:0001578)1.62975583
152Onycholysis (HP:0001806)1.62301290
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62283714
154Absent epiphyses (HP:0010577)1.62283714
155Abnormality of the acetabulum (HP:0003170)1.61727463
156Abnormality of subcutaneous fat tissue (HP:0001001)1.61684264
157Abnormal ossification of hand bones (HP:0005921)1.61328223
158Vertebral hypoplasia (HP:0008417)1.61036339
159Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.61036339
160Proximal placement of thumb (HP:0009623)1.60996775
161Ankle contracture (HP:0006466)1.60778611
162Irregular vertebral endplates (HP:0003301)1.59483602
163Abnormality of the pons (HP:0007361)1.58927470
164Protuberant abdomen (HP:0001538)1.58743146
165Abnormality of alkaline phosphatase activity (HP:0004379)1.58182929
166Elevated alkaline phosphatase (HP:0003155)1.57883065
167* Type I transferrin isoform profile (HP:0003642)1.56559482
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.55944692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.88268698
2ERN14.27434349
3VRK23.36830582
4FLT33.18407240
5MAPK152.93421492
6SCYL22.86706029
7INSRR2.72389542
8SMG12.70210225
9TRIB32.67136582
10BCKDK2.62236863
11EIF2AK32.49577413
12TAOK32.17897956
13PKN22.14305398
14TESK12.08275372
15SRPK12.06831914
16BUB12.06777927
17PBK2.06121551
18MST1R2.05955123
19BRSK21.97620928
20STK161.86250741
21TESK21.84465172
22HIPK21.62518290
23TTK1.58445824
24EEF2K1.56070211
25NME21.51565999
26WEE11.50635098
27KDR1.46511472
28MAP3K101.34520010
29PAK41.32318823
30EPHA21.31212572
31MAPKAPK31.27914251
32IRAK31.25438369
33ARAF1.21958799
34TIE11.21445096
35MAP2K21.21287663
36PTK61.19475247
37PDGFRA1.19473134
38PIM21.18682304
39ERBB41.18667904
40LMTK21.18508608
41LRRK21.16487292
42ZAP701.16307457
43RPS6KA41.14774886
44TGFBR11.11254265
45ICK1.10612303
46NEK21.09439829
47EPHB21.08412369
48EIF2AK11.03680567
49MAP3K31.01457024
50PDK21.00467229
51MAP3K21.00435792
52NME10.98845143
53PIK3CG0.98439367
54WNK40.97506808
55ACVR1B0.96651990
56BTK0.96607488
57SIK10.96539934
58PTK20.95508899
59BRSK10.94537008
60RPS6KB20.94459451
61CDC70.94348478
62JAK30.94030599
63VRK10.90936630
64DYRK30.87116164
65DYRK1B0.86304237
66CLK10.84418470
67TTN0.82765818
68TAOK20.82732074
69MET0.82660747
70TEC0.80648251
71DAPK10.79628712
72MAP3K120.78871096
73LIMK10.77702795
74FRK0.76768349
75MAP3K80.76744590
76CDK70.76254441
77MAP3K10.75622849
78EPHA30.73868005
79NEK90.73449206
80CAMKK20.72781867
81PRKD30.71264058
82ABL20.70845002
83WNK30.69994035
84TBK10.69154338
85PAK20.66238317
86PRKCI0.65741063
87MAP2K30.65509779
88AURKB0.65430704
89LATS20.64967446
90BLK0.64366033
91PRPF4B0.61139844
92CHEK20.60932947
93CDK90.60137324
94MAP3K110.58475444
95IRAK40.58458511
96TYK20.57651833
97MAP4K10.57432033
98DAPK30.57224643
99DDR20.56280692
100NTRK10.56217794
101ILK0.55460587
102STK40.53580621
103KIT0.53477670
104ATR0.51252437
105BRAF0.50728869
106STK100.50635443
107TLK10.50066499
108UHMK10.50026086
109IRAK10.49393754
110PLK30.48209931
111MTOR0.48053751
112PLK10.47924309
113EPHB10.47427667
114AURKA0.46989658
115ITK0.46925210
116TSSK60.46251341
117CDK60.46167980
118CHEK10.45788477
119BMX0.45075220
120MYLK0.43257915
121MAPK110.42002074
122AKT20.40760510
123MST40.40655178
124CSNK1G30.40246043
125FGFR40.40140923
126PAK10.39884519
127NEK10.39068744
128CDK120.39026564
129CDC42BPA0.38223877
130PRKG20.37383690
131RIPK10.35772649
132CSNK2A10.35175590
133MAPKAPK20.35008734
134CDK80.33578442
135CDK40.31555734
136NLK0.30077985
137TGFBR20.29642779
138JAK20.28400010

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.22699739
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.18691181
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.00638517
4* N-Glycan biosynthesis_Homo sapiens_hsa005102.76974099
5DNA replication_Homo sapiens_hsa030302.65731141
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46454151
7Other glycan degradation_Homo sapiens_hsa005112.40079089
8Sulfur metabolism_Homo sapiens_hsa009202.23919704
9Fatty acid elongation_Homo sapiens_hsa000622.21340227
10Selenocompound metabolism_Homo sapiens_hsa004502.15593275
11Mismatch repair_Homo sapiens_hsa034302.07412213
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.06219313
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.97626678
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96066488
15Folate biosynthesis_Homo sapiens_hsa007901.92433153
16Ribosome_Homo sapiens_hsa030101.86540188
17Lysosome_Homo sapiens_hsa041421.68984770
18Proteasome_Homo sapiens_hsa030501.65440762
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57137832
20Antigen processing and presentation_Homo sapiens_hsa046121.56215884
21Vibrio cholerae infection_Homo sapiens_hsa051101.55175793
22Base excision repair_Homo sapiens_hsa034101.54757232
23One carbon pool by folate_Homo sapiens_hsa006701.52389010
24Galactose metabolism_Homo sapiens_hsa000521.46854623
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.46751061
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37704736
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34334696
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32577174
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32389501
30Pyrimidine metabolism_Homo sapiens_hsa002401.30105394
31Spliceosome_Homo sapiens_hsa030401.21145780
32Homologous recombination_Homo sapiens_hsa034401.19308221
33Steroid biosynthesis_Homo sapiens_hsa001001.07275218
34Nucleotide excision repair_Homo sapiens_hsa034201.06059201
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04044587
36Legionellosis_Homo sapiens_hsa051341.03746389
37RNA transport_Homo sapiens_hsa030131.03048391
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.02823454
39Pyruvate metabolism_Homo sapiens_hsa006201.01322501
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00514085
41Cell cycle_Homo sapiens_hsa041100.96532936
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96254670
43Oxidative phosphorylation_Homo sapiens_hsa001900.90323081
44Pentose phosphate pathway_Homo sapiens_hsa000300.90304111
45Renin-angiotensin system_Homo sapiens_hsa046140.87494841
46RNA polymerase_Homo sapiens_hsa030200.84863391
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84445533
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83708019
49Parkinsons disease_Homo sapiens_hsa050120.82854097
50Shigellosis_Homo sapiens_hsa051310.80019794
51Protein digestion and absorption_Homo sapiens_hsa049740.79765553
52Thyroid cancer_Homo sapiens_hsa052160.76493088
53Bladder cancer_Homo sapiens_hsa052190.74396150
54Type I diabetes mellitus_Homo sapiens_hsa049400.73865864
55Fatty acid metabolism_Homo sapiens_hsa012120.73699768
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.72037682
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69121987
58Fat digestion and absorption_Homo sapiens_hsa049750.66889617
59Thyroid hormone synthesis_Homo sapiens_hsa049180.66532729
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66195079
61Huntingtons disease_Homo sapiens_hsa050160.65778782
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64934309
63Insulin secretion_Homo sapiens_hsa049110.64686225
64Sulfur relay system_Homo sapiens_hsa041220.62208512
65p53 signaling pathway_Homo sapiens_hsa041150.62198190
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57311423
67Viral carcinogenesis_Homo sapiens_hsa052030.56879858
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56228416
69Fructose and mannose metabolism_Homo sapiens_hsa000510.55274772
70RNA degradation_Homo sapiens_hsa030180.53491039
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53155023
72Starch and sucrose metabolism_Homo sapiens_hsa005000.52262572
73Purine metabolism_Homo sapiens_hsa002300.51951414
74Biosynthesis of amino acids_Homo sapiens_hsa012300.51150955
75Pancreatic secretion_Homo sapiens_hsa049720.51099924
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51010996
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49223451
78Non-homologous end-joining_Homo sapiens_hsa034500.49135019
79Arginine biosynthesis_Homo sapiens_hsa002200.48408425
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47017398
81Glutathione metabolism_Homo sapiens_hsa004800.46949194
82Tryptophan metabolism_Homo sapiens_hsa003800.45293854
83Vitamin digestion and absorption_Homo sapiens_hsa049770.44787183
84Insulin resistance_Homo sapiens_hsa049310.44716283
85Alzheimers disease_Homo sapiens_hsa050100.44434695
86Prion diseases_Homo sapiens_hsa050200.44145751
87Proteoglycans in cancer_Homo sapiens_hsa052050.42560896
88Carbon metabolism_Homo sapiens_hsa012000.42261794
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39840649
90Vitamin B6 metabolism_Homo sapiens_hsa007500.39066936
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38480025
92Epstein-Barr virus infection_Homo sapiens_hsa051690.38218896
93Pancreatic cancer_Homo sapiens_hsa052120.38189496
94Arginine and proline metabolism_Homo sapiens_hsa003300.38071836
95Phenylalanine metabolism_Homo sapiens_hsa003600.38010270
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36251266
97Focal adhesion_Homo sapiens_hsa045100.35125573
98mRNA surveillance pathway_Homo sapiens_hsa030150.34813726
99Tyrosine metabolism_Homo sapiens_hsa003500.34442030
100Systemic lupus erythematosus_Homo sapiens_hsa053220.34314007
101Fanconi anemia pathway_Homo sapiens_hsa034600.33937072
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.33865129
103Apoptosis_Homo sapiens_hsa042100.33374637
104HTLV-I infection_Homo sapiens_hsa051660.30816509
105* Metabolic pathways_Homo sapiens_hsa011000.29767742
106Small cell lung cancer_Homo sapiens_hsa052220.29261682
107Phagosome_Homo sapiens_hsa041450.28610762
108ABC transporters_Homo sapiens_hsa020100.28594333
109Type II diabetes mellitus_Homo sapiens_hsa049300.28520129
110HIF-1 signaling pathway_Homo sapiens_hsa040660.26723248
111Fatty acid degradation_Homo sapiens_hsa000710.26696184
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26636960
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26386827
114Sphingolipid metabolism_Homo sapiens_hsa006000.26016637
115Complement and coagulation cascades_Homo sapiens_hsa046100.25514353
116ECM-receptor interaction_Homo sapiens_hsa045120.25206844
117Chronic myeloid leukemia_Homo sapiens_hsa052200.25033321
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24750499
119Regulation of autophagy_Homo sapiens_hsa041400.24450061
120Alcoholism_Homo sapiens_hsa050340.23712420
121Adherens junction_Homo sapiens_hsa045200.23585956
122Herpes simplex infection_Homo sapiens_hsa051680.22959949
123Lysine degradation_Homo sapiens_hsa003100.22378797
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20603505
125Histidine metabolism_Homo sapiens_hsa003400.20319987
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19989509
127Acute myeloid leukemia_Homo sapiens_hsa052210.19704286
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19374899
129Leishmaniasis_Homo sapiens_hsa051400.19095552
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.18831164
131Glucagon signaling pathway_Homo sapiens_hsa049220.18593362

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