DDRGK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.78394238
2L-phenylalanine catabolic process (GO:0006559)6.78394238
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.53994820
4L-phenylalanine metabolic process (GO:0006558)6.53994820
5aromatic amino acid family catabolic process (GO:0009074)5.51242077
6protein retention in ER lumen (GO:0006621)4.80685444
7glyoxylate metabolic process (GO:0046487)4.79864177
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.65954746
9alpha-linolenic acid metabolic process (GO:0036109)4.59297460
10bile acid biosynthetic process (GO:0006699)4.58930111
11cysteine metabolic process (GO:0006534)4.53407066
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.51080255
13sulfur amino acid catabolic process (GO:0000098)4.44399549
14indole-containing compound catabolic process (GO:0042436)4.40971329
15indolalkylamine catabolic process (GO:0046218)4.40971329
16tryptophan catabolic process (GO:0006569)4.40971329
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.29721298
18kynurenine metabolic process (GO:0070189)4.26566176
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.25200533
20protein maturation by protein folding (GO:0022417)4.18040407
21tryptophan metabolic process (GO:0006568)4.14332036
22positive regulation of lipoprotein lipase activity (GO:0051006)4.07262530
23positive regulation of triglyceride lipase activity (GO:0061365)4.07262530
24regulation of triglyceride catabolic process (GO:0010896)4.06387101
25high-density lipoprotein particle remodeling (GO:0034375)4.05998913
26fatty acid elongation (GO:0030497)4.05079761
27aromatic amino acid family metabolic process (GO:0009072)4.00674624
28peptidyl-glutamic acid carboxylation (GO:0017187)3.99928538
29protein carboxylation (GO:0018214)3.99928538
30very-low-density lipoprotein particle assembly (GO:0034379)3.95545839
31coenzyme catabolic process (GO:0009109)3.93805130
32bile acid metabolic process (GO:0008206)3.93584856
33plasma lipoprotein particle assembly (GO:0034377)3.91008026
34lysine catabolic process (GO:0006554)3.90022784
35lysine metabolic process (GO:0006553)3.90022784
36short-chain fatty acid metabolic process (GO:0046459)3.89104126
37protein-lipid complex assembly (GO:0065005)3.88502573
38proline biosynthetic process (GO:0006561)3.84975298
39cellular ketone body metabolic process (GO:0046950)3.84080162
40heme transport (GO:0015886)3.82764768
41tyrosine metabolic process (GO:0006570)3.80599395
42very long-chain fatty acid metabolic process (GO:0000038)3.77698755
43urea cycle (GO:0000050)3.77504659
44urea metabolic process (GO:0019627)3.77504659
45negative regulation of fibrinolysis (GO:0051918)3.77244929
46acetyl-CoA metabolic process (GO:0006084)3.76924087
47regulation of cholesterol esterification (GO:0010872)3.75384916
48triglyceride homeostasis (GO:0070328)3.73362776
49acylglycerol homeostasis (GO:0055090)3.73362776
50plasma lipoprotein particle clearance (GO:0034381)3.70102232
51complement activation, alternative pathway (GO:0006957)3.68648024
52alpha-amino acid catabolic process (GO:1901606)3.67039631
53ethanol oxidation (GO:0006069)3.65603981
54proline metabolic process (GO:0006560)3.64186383
55nitrogen cycle metabolic process (GO:0071941)3.63451389
56GDP-mannose metabolic process (GO:0019673)3.61367388
57regulation of fibrinolysis (GO:0051917)3.60426915
58cofactor catabolic process (GO:0051187)3.59985155
59Golgi transport vesicle coating (GO:0048200)3.59754848
60COPI coating of Golgi vesicle (GO:0048205)3.59754848
61aspartate family amino acid catabolic process (GO:0009068)3.58554922
62ribosomal small subunit biogenesis (GO:0042274)3.57880708
63amino-acid betaine metabolic process (GO:0006577)3.56660894
64fatty acid beta-oxidation (GO:0006635)3.56401408
65serine family amino acid catabolic process (GO:0009071)3.53743995
66homocysteine metabolic process (GO:0050667)3.52673436
67fatty acid catabolic process (GO:0009062)3.51140946
68cellular amino acid catabolic process (GO:0009063)3.50743334
69regulation of protein activation cascade (GO:2000257)3.49358361
70aldehyde catabolic process (GO:0046185)3.48778861
71regulation of cholesterol homeostasis (GO:2000188)3.46673641
72reverse cholesterol transport (GO:0043691)3.46045318
73plasma lipoprotein particle remodeling (GO:0034369)3.45731145
74protein-lipid complex remodeling (GO:0034368)3.45731145
75macromolecular complex remodeling (GO:0034367)3.45731145
76drug transmembrane transport (GO:0006855)3.45182367
774-hydroxyproline metabolic process (GO:0019471)3.45110052
78fatty acid oxidation (GO:0019395)3.44145150
79response to mercury ion (GO:0046689)3.39549245
80low-density lipoprotein particle clearance (GO:0034383)3.39357946
81lipid oxidation (GO:0034440)3.37282258
82monocarboxylic acid catabolic process (GO:0072329)3.36645227
83protein localization to endosome (GO:0036010)3.36562254
84glucose 6-phosphate metabolic process (GO:0051156)3.35954333
85regulation of cholesterol metabolic process (GO:0090181)3.35952095
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.35324852
87ketone body metabolic process (GO:1902224)3.35131565
88oligosaccharide catabolic process (GO:0009313)3.34796066
89bile acid and bile salt transport (GO:0015721)3.32674554
90phospholipid efflux (GO:0033700)3.32117794
91organic acid catabolic process (GO:0016054)3.31355463
92carboxylic acid catabolic process (GO:0046395)3.31355463
93glutamate metabolic process (GO:0006536)3.30805229
94regulation of complement activation (GO:0030449)3.26973458
95glycosphingolipid catabolic process (GO:0046479)3.26875519
96amine catabolic process (GO:0009310)3.26496319
97cellular biogenic amine catabolic process (GO:0042402)3.26496319
98negative regulation of cholesterol transport (GO:0032375)3.24989028
99negative regulation of sterol transport (GO:0032372)3.24989028
100cholesterol efflux (GO:0033344)3.24897412
101benzene-containing compound metabolic process (GO:0042537)3.24759129
102cellular modified amino acid catabolic process (GO:0042219)3.24610793
103thioester metabolic process (GO:0035383)3.23727159
104acyl-CoA metabolic process (GO:0006637)3.23727159
105regulation of superoxide anion generation (GO:0032928)3.22787065
106serine family amino acid metabolic process (GO:0009069)3.22648608
107fatty-acyl-CoA biosynthetic process (GO:0046949)3.21874615
108serine family amino acid biosynthetic process (GO:0009070)3.21425022
109branched-chain amino acid catabolic process (GO:0009083)3.18021618
110indolalkylamine metabolic process (GO:0006586)3.17599490
111regulation of early endosome to late endosome transport (GO:2000641)3.16989362
112acyl-CoA biosynthetic process (GO:0071616)3.16825971
113thioester biosynthetic process (GO:0035384)3.16825971
114cholesterol homeostasis (GO:0042632)3.16742974
115positive regulation of triglyceride metabolic process (GO:0090208)3.16735616
116sterol homeostasis (GO:0055092)3.10688450
117creatine metabolic process (GO:0006600)3.10613713
118adhesion of symbiont to host (GO:0044406)3.10309357
119cellular glucuronidation (GO:0052695)3.09948566
120regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09535332
121negative regulation of lipase activity (GO:0060192)3.08585708
122regulation of cholesterol biosynthetic process (GO:0045540)3.08312624
123valine metabolic process (GO:0006573)3.08191328
124fatty-acyl-CoA metabolic process (GO:0035337)3.06608153
125regulation of cholesterol storage (GO:0010885)3.05625805
126positive regulation of fatty acid biosynthetic process (GO:0045723)2.99360006
127cellular copper ion homeostasis (GO:0006878)2.96861479
128UV protection (GO:0009650)2.94052387
129glycolipid catabolic process (GO:0019377)2.93159940
130serine transport (GO:0032329)2.90223876
131positive regulation of cellular amine metabolic process (GO:0033240)2.89431854
132pentose metabolic process (GO:0019321)2.89423343
133low-density lipoprotein particle remodeling (GO:0034374)2.89133137
134regulation of apoptotic cell clearance (GO:2000425)2.87711597
135NADH metabolic process (GO:0006734)2.83454033
136protein-lipid complex subunit organization (GO:0071825)2.82454977
137negative regulation of fatty acid biosynthetic process (GO:0045717)2.81994722
138pinocytosis (GO:0006907)2.79188356
139plasma lipoprotein particle organization (GO:0071827)2.76906334
140endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.76218961
141barbed-end actin filament capping (GO:0051016)2.72974400
142protein insertion into membrane (GO:0051205)2.72410069
143amyloid precursor protein catabolic process (GO:0042987)2.69698509
144regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.69413763
145positive regulation of extracellular matrix organization (GO:1903055)2.69274825
146regulation of fatty acid biosynthetic process (GO:0042304)2.65160158
147activation of MAPKKK activity (GO:0000185)2.63013307
148glucose catabolic process (GO:0006007)2.62243818
149activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62172701
150modulation by symbiont of host cellular process (GO:0044068)2.61925531
151glutamine family amino acid biosynthetic process (GO:0009084)2.61212784
152glutathione biosynthetic process (GO:0006750)2.60731719
153peptidyl-proline hydroxylation (GO:0019511)2.60226918
154pentose-phosphate shunt (GO:0006098)2.58942465
155cell-cell junction maintenance (GO:0045217)2.58653376
156response to thyroid hormone (GO:0097066)2.56407650
157acute-phase response (GO:0006953)2.55845110
158fibrinolysis (GO:0042730)2.53241169
159adhesion of symbiont to host cell (GO:0044650)2.53068869
160virion attachment to host cell (GO:0019062)2.53068869
161regulation of plasminogen activation (GO:0010755)2.52946160
162monosaccharide biosynthetic process (GO:0046364)2.52572484
163positive regulation of nuclease activity (GO:0032075)2.51299741
164amino sugar catabolic process (GO:0046348)2.51171551
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.51096271
166L-serine transport (GO:0015825)2.50553066
167apoptotic process involved in morphogenesis (GO:0060561)2.50303892
168basement membrane organization (GO:0071711)2.48447792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.88729190
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.39033758
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.45616733
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.37492826
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.93904867
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.75094067
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.48551192
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17044526
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.05998404
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.16680369
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.82441607
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.79691445
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45604640
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27661101
15VDR_21846776_ChIP-Seq_THP-1_Human2.20127032
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08020211
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96567732
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.90718146
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76606384
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75281869
21CLOCK_20551151_ChIP-Seq_293T_Human1.72317440
22P68_20966046_ChIP-Seq_HELA_Human1.71836476
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71238741
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58032297
25MYC_22102868_ChIP-Seq_BL_Human1.57675376
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57080299
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55152827
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54932928
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53740044
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53127827
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51836177
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.49735072
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.49646851
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48255324
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.47650461
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47457137
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46632755
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45398990
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44422244
40SMC4_20622854_ChIP-Seq_HELA_Human1.43461655
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41881629
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39905888
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39512965
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36227305
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35850240
46KDM2B_26808549_Chip-Seq_K562_Human1.35159605
47BCL6_27268052_Chip-Seq_Bcells_Human1.33063308
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31245047
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30100116
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29259085
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.29178923
52* XRN2_22483619_ChIP-Seq_HELA_Human1.28903845
53KDM2B_26808549_Chip-Seq_DND41_Human1.25092944
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23943462
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23444684
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22436012
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22175827
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21692134
59HTT_18923047_ChIP-ChIP_STHdh_Human1.20683729
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19723142
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.19619776
62ATF3_27146783_Chip-Seq_COLON_Human1.19479355
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19164406
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18989766
65GATA1_22025678_ChIP-Seq_K562_Human1.18826460
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18334298
67RARA_24833708_ChIP-Seq_LIVER_Mouse1.17926361
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14528241
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14513508
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13307451
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12025217
72TCF7_22412390_ChIP-Seq_EML_Mouse1.11042187
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10723414
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09621831
75CREB1_26743006_Chip-Seq_LNCaP_Human1.09576123
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09204880
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08742620
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08514400
79PHF8_20622854_ChIP-Seq_HELA_Human1.06353377
80LXR_22292898_ChIP-Seq_THP-1_Human1.05294115
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05222967
82TP53_22127205_ChIP-Seq_IMR90_Human1.04819294
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03988941
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.03874996
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03825880
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03281293
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.02854765
88GABP_19822575_ChIP-Seq_HepG2_Human1.02816521
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02319482
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.02229381
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02219710
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02078164
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99531525
94SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99440950
95E2F1_20622854_ChIP-Seq_HELA_Human0.99016631
96VDR_24763502_ChIP-Seq_THP-1_Human0.97657071
97NCOR1_26117541_ChIP-Seq_K562_Human0.97335719
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96468617
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.95667496
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95654236
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94946749
102HNF4A_19822575_ChIP-Seq_HepG2_Human0.92065052
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90675577
104RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90537916
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90381382
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90275683
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90097813
108GATA1_19941826_ChIP-Seq_K562_Human0.86574736
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83927296
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83927296
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82215645
112GATA4_25053715_ChIP-Seq_YYC3_Human0.81522827
113EGR1_19032775_ChIP-ChIP_M12_Human0.80644985
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77656926
115SOX2_20726797_ChIP-Seq_SW620_Human0.75506320
116CTCF_20526341_ChIP-Seq_ESCs_Human0.74691989
117* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74440947
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.74110670
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74043015
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73943610
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72822160
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.72284503
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72154782
124MYC_19915707_ChIP-ChIP_AK7_Human0.72118619
125BCOR_27268052_Chip-Seq_Bcells_Human0.71526890
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.71168244
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71128567
128GATA2_19941826_ChIP-Seq_K562_Human0.69650823
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.69626704
130CEBPB_22108803_ChIP-Seq_LS180_Human0.69304440
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68764354
132P53_21459846_ChIP-Seq_SAOS-2_Human0.68127254
133ZNF263_19887448_ChIP-Seq_K562_Human0.66726323
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66675928
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66511490
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.66222810
137SA1_27219007_Chip-Seq_Bcells_Human0.65582291
138NANOG_20526341_ChIP-Seq_ESCs_Human0.64978194
139AR_20517297_ChIP-Seq_VCAP_Human0.64930306
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64915911
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.64908718
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.64848975
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63874909
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.63855943
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.63787253
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.62766612
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62560924
148Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.62535680
149OCT4_20526341_ChIP-Seq_ESCs_Human0.62455654
150* TAF2_19829295_ChIP-Seq_ESCs_Human0.62298413
151RACK7_27058665_Chip-Seq_MCF-7_Human0.61762775
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.61601274
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61517577
154CTCF_27219007_Chip-Seq_Bcells_Human0.61194685
155FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.60851973
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60430859
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.59262725
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.58838464
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.58784000
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58773358
161AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58295774
162CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57992296
163RARB_24833708_ChIP-Seq_LIVER_Mouse0.57889095
164* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.56763443
165ESR1_21235772_ChIP-Seq_MCF-7_Human0.56574111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.70847193
2MP0005360_urolithiasis5.94307689
3MP0005365_abnormal_bile_salt5.12177048
4MP0005085_abnormal_gallbladder_physiolo4.74411969
5MP0008875_abnormal_xenobiotic_pharmacok4.26108525
6MP0003806_abnormal_nucleotide_metabolis3.99732769
7MP0008260_abnormal_autophagy3.30763808
8MP0009840_abnormal_foam_cell3.27357903
9MP0003191_abnormal_cellular_cholesterol3.22024284
10MP0003195_calcinosis2.99406630
11MP0003172_abnormal_lysosome_physiology2.98269020
12MP0010329_abnormal_lipoprotein_level2.96431335
13MP0005332_abnormal_amino_acid2.85964967
14MP0005083_abnormal_biliary_tract2.80903823
15MP0003252_abnormal_bile_duct2.77992959
16MP0000678_abnormal_parathyroid_gland2.71858956
17MP0003123_paternal_imprinting2.45440224
18MP0001666_abnormal_nutrient_absorption2.40896477
19MP0002118_abnormal_lipid_homeostasis2.13050561
20MP0004858_abnormal_nervous_system2.05037751
21MP0005451_abnormal_body_composition2.03548164
22MP0003329_amyloid_beta_deposits1.86736721
23MP0003705_abnormal_hypodermis_morpholog1.85060792
24MP0003453_abnormal_keratinocyte_physiol1.84643782
25MP0000609_abnormal_liver_physiology1.79473297
26MP0004019_abnormal_vitamin_homeostasis1.77936792
27MP0005584_abnormal_enzyme/coenzyme_acti1.75492681
28MP0004510_myositis1.75192885
29MP0000920_abnormal_myelination1.68694854
30MP0005319_abnormal_enzyme/_coenzyme1.68075174
31MP0009643_abnormal_urine_homeostasis1.65427466
32MP0000604_amyloidosis1.65133349
33MP0002089_abnormal_postnatal_growth/wei1.64596561
34MP0003186_abnormal_redox_activity1.60365208
35MP0005058_abnormal_lysosome_morphology1.57423587
36MP0002138_abnormal_hepatobiliary_system1.55672909
37MP0003656_abnormal_erythrocyte_physiolo1.52053440
38MP0003436_decreased_susceptibility_to1.51861823
39MP0003879_abnormal_hair_cell1.50711117
40MP0004043_abnormal_pH_regulation1.48459637
41MP0003303_peritoneal_inflammation1.45883537
42MP0001764_abnormal_homeostasis1.44715071
43MP0005410_abnormal_fertilization1.43747531
44MP0000858_altered_metastatic_potential1.43538734
45MP0001849_ear_inflammation1.41957907
46MP0006036_abnormal_mitochondrial_physio1.41292533
47MP0003690_abnormal_glial_cell1.41235587
48MP0005257_abnormal_intraocular_pressure1.36422837
49MP0000681_abnormal_thyroid_gland1.35975057
50MP0003011_delayed_dark_adaptation1.33476463
51MP0005636_abnormal_mineral_homeostasis1.30476513
52MP0003183_abnormal_peptide_metabolism1.28191628
53MP0003566_abnormal_cell_adhesion1.26940360
54MP0003868_abnormal_feces_composition1.26695808
55MP0002877_abnormal_melanocyte_morpholog1.26378526
56MP0005501_abnormal_skin_physiology1.24204725
57MP0005670_abnormal_white_adipose1.20842310
58MP0009333_abnormal_splenocyte_physiolog1.20550392
59MP0002249_abnormal_larynx_morphology1.15907432
60MP0000003_abnormal_adipose_tissue1.12514262
61MP0001853_heart_inflammation1.09946295
62MP0010234_abnormal_vibrissa_follicle1.06879002
63MP0000343_altered_response_to1.05461184
64MP0005076_abnormal_cell_differentiation1.04346678
65MP0004233_abnormal_muscle_weight1.04203635
66MP0004130_abnormal_muscle_cell0.97796372
67MP0009278_abnormal_bone_marrow0.96282113
68MP0005023_abnormal_wound_healing0.96044524
69MP0005166_decreased_susceptibility_to0.95711789
70MP0008469_abnormal_protein_level0.95510802
71MP0002837_dystrophic_cardiac_calcinosis0.94480111
72MP0001661_extended_life_span0.94459249
73MP0002876_abnormal_thyroid_physiology0.93411541
74MP0005535_abnormal_body_temperature0.92898613
75MP0001915_intracranial_hemorrhage0.92112106
76MP0005408_hypopigmentation0.91850821
77MP0001756_abnormal_urination0.91809314
78MP0004147_increased_porphyrin_level0.90361503
79MP0005647_abnormal_sex_gland0.90254101
80MP0003724_increased_susceptibility_to0.90099699
81MP0005623_abnormal_meninges_morphology0.89912982
82MP0009379_abnormal_foot_pigmentation0.89584828
83MP0000566_synostosis0.88005069
84MP0009642_abnormal_blood_homeostasis0.87620051
85MP0000598_abnormal_liver_morphology0.86780853
86MP0004859_abnormal_synaptic_plasticity0.86548816
87MP0002971_abnormal_brown_adipose0.83965414
88MP0004947_skin_inflammation0.83641795
89MP0000747_muscle_weakness0.82446783
90MP0002078_abnormal_glucose_homeostasis0.82367789
91MP0009763_increased_sensitivity_to0.82093880
92MP0005666_abnormal_adipose_tissue0.81898092
93MP0003122_maternal_imprinting0.81379915
94MP0002132_abnormal_respiratory_system0.80871068
95MP0005084_abnormal_gallbladder_morpholo0.80011603
96MP0009764_decreased_sensitivity_to0.76473701
97MP0005409_darkened_coat_color0.74811342
98MP0006082_CNS_inflammation0.73976695
99MP0005167_abnormal_blood-brain_barrier0.72862593
100MP0001730_embryonic_growth_arrest0.72828486
101MP0001765_abnormal_ion_homeostasis0.72232314
102MP0005220_abnormal_exocrine_pancreas0.70239045
103MP0005376_homeostasis/metabolism_phenot0.70203292
104MP0000230_abnormal_systemic_arterial0.68988909
105MP0004381_abnormal_hair_follicle0.68543547
106MP0005334_abnormal_fat_pad0.68225965
107MP0004272_abnormal_basement_membrane0.67633747
108MP0004264_abnormal_extraembryonic_tissu0.67307052
109MP0009697_abnormal_copulation0.66555838
110MP0009765_abnormal_xenobiotic_induced0.66274523
111MP0002136_abnormal_kidney_physiology0.65242586
112MP0003075_altered_response_to0.64652184
113MP0001216_abnormal_epidermal_layer0.64649388
114MP0002998_abnormal_bone_remodeling0.63788180
115MP0005397_hematopoietic_system_phenotyp0.63718227
116MP0001545_abnormal_hematopoietic_system0.63718227
117MP0000639_abnormal_adrenal_gland0.62337779
118MP0001533_abnormal_skeleton_physiology0.61749356
119MP0009785_altered_susceptibility_to0.60479821
120MP0002295_abnormal_pulmonary_circulatio0.59968822
121MP0005025_abnormal_response_to0.58133533
122MP0003638_abnormal_response/metabolism_0.57436807
123MP0004185_abnormal_adipocyte_glucose0.57435900
124MP0002229_neurodegeneration0.57425759
125MP0005375_adipose_tissue_phenotype0.55645662
126MP0004036_abnormal_muscle_relaxation0.55640897
127MP0002148_abnormal_hypersensitivity_rea0.55573534
128MP0000749_muscle_degeneration0.54571478
129MP0006035_abnormal_mitochondrial_morpho0.54267037
130MP0000537_abnormal_urethra_morphology0.54095384
131MP0005448_abnormal_energy_balance0.53180969
132MP0004142_abnormal_muscle_tone0.52522382
133MP0002822_catalepsy0.51850688
134MP0005266_abnormal_metabolism0.51727435
135MP0004782_abnormal_surfactant_physiolog0.51668781
136MP0008873_increased_physiological_sensi0.51218268
137MP0002090_abnormal_vision0.50465737
138MP0008874_decreased_physiological_sensi0.50249141
139MP0003315_abnormal_perineum_morphology0.50139037
140MP0003950_abnormal_plasma_membrane0.50079731
141MP0005330_cardiomyopathy0.49362517
142MP0001905_abnormal_dopamine_level0.47819755
143MP0005551_abnormal_eye_electrophysiolog0.47130379
144MP0003632_abnormal_nervous_system0.46075747
145MP0003634_abnormal_glial_cell0.45760567
146MP0003953_abnormal_hormone_level0.45217058
147MP0003633_abnormal_nervous_system0.44689061
148MP0005464_abnormal_platelet_physiology0.44594588
149MP0002796_impaired_skin_barrier0.43858211
150MP0003959_abnormal_lean_body0.43163678
151MP0005165_increased_susceptibility_to0.41051544
152MP0010368_abnormal_lymphatic_system0.40641093
153MP0003631_nervous_system_phenotype0.40032483
154MP0000249_abnormal_blood_vessel0.38831595
155MP0005595_abnormal_vascular_smooth0.38362403

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43563185
2Intrahepatic cholestasis (HP:0001406)5.27357808
3Deep venous thrombosis (HP:0002625)5.00657778
4Xanthomatosis (HP:0000991)4.87426604
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.49961562
6Hyperlipoproteinemia (HP:0010980)4.44384292
7Prolonged partial thromboplastin time (HP:0003645)4.35864103
8Abnormality of liposaccharide metabolism (HP:0010968)4.09366268
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.09366268
10Abnormality of glycolipid metabolism (HP:0010969)4.09366268
11Ketosis (HP:0001946)3.98344556
12Hypobetalipoproteinemia (HP:0003563)3.98213989
13Hyperammonemia (HP:0001987)3.82872765
14Complement deficiency (HP:0004431)3.80434001
15Abnormality of glycine metabolism (HP:0010895)3.71292121
16Abnormality of serine family amino acid metabolism (HP:0010894)3.71292121
17Abnormality of fatty-acid metabolism (HP:0004359)3.66757138
18Hyperglycinuria (HP:0003108)3.54907489
19Hyperglycinemia (HP:0002154)3.48473305
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45020609
21Vertebral compression fractures (HP:0002953)3.40371928
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.38600342
23Hypoglycemic coma (HP:0001325)3.28243605
24Fat malabsorption (HP:0002630)3.27285841
25Ketoacidosis (HP:0001993)3.21129500
26Abnormality of methionine metabolism (HP:0010901)3.20811718
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.15777395
28Abnormality of the common coagulation pathway (HP:0010990)3.15555886
29Dysostosis multiplex (HP:0000943)3.13984050
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.12645214
31Joint hemorrhage (HP:0005261)3.09661549
32Hypolipoproteinemia (HP:0010981)3.08692344
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.01006371
34Abnormality of the Achilles tendon (HP:0005109)3.00769734
35Dicarboxylic aciduria (HP:0003215)2.97001104
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97001104
37Cerebral edema (HP:0002181)2.87604084
38Achilles tendon contracture (HP:0001771)2.86558185
39Nuclear cataract (HP:0100018)2.82985078
40Hypoalphalipoproteinemia (HP:0003233)2.81432471
41Lethargy (HP:0001254)2.77190898
42Steatorrhea (HP:0002570)2.76657544
43Gout (HP:0001997)2.75939652
44Purpura (HP:0000979)2.73446770
45Abnormality of the intrinsic pathway (HP:0010989)2.71465781
46Metabolic acidosis (HP:0001942)2.70575871
47Epidermoid cyst (HP:0200040)2.70564128
48Conjugated hyperbilirubinemia (HP:0002908)2.69398760
49Loss of speech (HP:0002371)2.69013295
50Delayed CNS myelination (HP:0002188)2.68356409
51Hepatic necrosis (HP:0002605)2.68170978
52Neurofibrillary tangles (HP:0002185)2.67752349
53Abnormality of complement system (HP:0005339)2.60339320
54Generalized aminoaciduria (HP:0002909)2.59855383
55Supranuclear gaze palsy (HP:0000605)2.59828396
56Hyperbilirubinemia (HP:0002904)2.59581334
57Prolonged neonatal jaundice (HP:0006579)2.55410636
58Acute encephalopathy (HP:0006846)2.54060544
59Abnormality of purine metabolism (HP:0004352)2.52064324
60Upper limb amyotrophy (HP:0009129)2.45907119
61Distal upper limb amyotrophy (HP:0007149)2.45907119
62Systemic lupus erythematosus (HP:0002725)2.44487265
63Alkalosis (HP:0001948)2.44283417
64Axonal loss (HP:0003447)2.43917738
65Abnormality of serum amino acid levels (HP:0003112)2.43874346
66Hyperacusis (HP:0010780)2.41242545
67Mucopolysacchariduria (HP:0008155)2.40153415
68Urinary glycosaminoglycan excretion (HP:0003541)2.40153415
69Abnormality of polysaccharide metabolism (HP:0011012)2.40024768
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40024768
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40024768
72Vomiting (HP:0002013)2.38337819
73Hypercholesterolemia (HP:0003124)2.37936265
74Increased cerebral lipofuscin (HP:0011813)2.37088743
75Glycosuria (HP:0003076)2.36791654
76Abnormality of urine glucose concentration (HP:0011016)2.36791654
77Personality changes (HP:0000751)2.35785732
78Hepatocellular necrosis (HP:0001404)2.33741018
79Neuronal loss in central nervous system (HP:0002529)2.32105693
80Vascular calcification (HP:0004934)2.31717772
81Abnormal gallbladder physiology (HP:0012438)2.30911756
82Cholecystitis (HP:0001082)2.30911756
83Spastic paraparesis (HP:0002313)2.30269542
84Amyloidosis (HP:0011034)2.29505854
85Abnormal gallbladder morphology (HP:0012437)2.28879854
86Abnormality of nucleobase metabolism (HP:0010932)2.26708516
87Irritability (HP:0000737)2.23573309
88Increased muscle lipid content (HP:0009058)2.22549950
89Parakeratosis (HP:0001036)2.20291170
90Hand muscle atrophy (HP:0009130)2.18829433
91Ragged-red muscle fibers (HP:0003200)2.18747867
92Upper motor neuron abnormality (HP:0002127)2.18476072
93Insomnia (HP:0100785)2.16701028
94Cholelithiasis (HP:0001081)2.16064560
95Brushfield spots (HP:0001088)2.15576352
96Hemorrhage of the eye (HP:0011885)2.13781469
97Methylmalonic aciduria (HP:0012120)2.11838314
98Late onset (HP:0003584)2.09791400
99Dementia (HP:0000726)2.08958396
100Flat acetabular roof (HP:0003180)2.08649242
101Cerebral hemorrhage (HP:0001342)2.08525254
102Progressive neurologic deterioration (HP:0002344)2.08235485
103Opisthotonus (HP:0002179)2.06710320
104Pancreatitis (HP:0001733)2.06477227
105Hypokalemic alkalosis (HP:0001949)2.06229032
106Vacuolated lymphocytes (HP:0001922)2.05314886
107Glomerulonephritis (HP:0000099)2.03831229
108Multiple enchondromatosis (HP:0005701)2.01494188
109Reticulocytosis (HP:0001923)2.00787769
110Hyperparathyroidism (HP:0000843)2.00069702
111Cardiovascular calcification (HP:0011915)1.99352227
112Abnormality of glycolysis (HP:0004366)1.98842303
113Increased serum pyruvate (HP:0003542)1.98842303
114Apathy (HP:0000741)1.98655211
115Increased serum ferritin (HP:0003281)1.95912732
116Athetosis (HP:0002305)1.95362058
117Hyperinsulinemic hypoglycemia (HP:0000825)1.94538129
118Methylmalonic acidemia (HP:0002912)1.94446131
119Hypoglycemic seizures (HP:0002173)1.93667225
120Skin nodule (HP:0200036)1.93261912
121Abnormality of carpal bone ossification (HP:0006257)1.92467952
122Sensorimotor neuropathy (HP:0007141)1.92292473
123Hypokinesia (HP:0002375)1.91667413
124Increased intramyocellular lipid droplets (HP:0012240)1.91591494
125Cerebral inclusion bodies (HP:0100314)1.91313220
126Diminished motivation (HP:0000745)1.91251502
127Polygenic inheritance (HP:0010982)1.91030287
128Proximal tubulopathy (HP:0000114)1.90718796
129Abnormality of transition element cation homeostasis (HP:0011030)1.90216159
130Hyperthyroidism (HP:0000836)1.88311911
131Asymmetric septal hypertrophy (HP:0001670)1.87786792
132Abnormality of iron homeostasis (HP:0011031)1.87534816
133Renal Fanconi syndrome (HP:0001994)1.86376235
134Myocardial infarction (HP:0001658)1.84080920
135Myoglobinuria (HP:0002913)1.83984764
136Malnutrition (HP:0004395)1.83148816
137Hyperuricemia (HP:0002149)1.82654451
138Increased purine levels (HP:0004368)1.82654451
139Abnormality of the gallbladder (HP:0005264)1.82267369
140Paraparesis (HP:0002385)1.82044653
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81865968
142Abnormal mitochondria in muscle tissue (HP:0008316)1.81857322
143Acute necrotizing encephalopathy (HP:0006965)1.81840529
144Mitochondrial inheritance (HP:0001427)1.79708062
145Diaphragmatic weakness (HP:0009113)1.79627042
146Increased neuronal autofluorescent lipopigment (HP:0002074)1.79435925
147Progressive muscle weakness (HP:0003323)1.79330436
148Back pain (HP:0003418)1.79121067
149Abnormality of the thoracic spine (HP:0100711)1.78878495
150Myokymia (HP:0002411)1.77698159
151Growth hormone excess (HP:0000845)1.77685923
152Protrusio acetabuli (HP:0003179)1.75846041
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74507608
154Pathologic fracture (HP:0002756)1.73137064
155Elevated alkaline phosphatase (HP:0003155)1.72087284
156Abnormality of alkaline phosphatase activity (HP:0004379)1.71729031
157Retinal atrophy (HP:0001105)1.70572980
158Thoracic kyphosis (HP:0002942)1.69975207
159Neonatal death (HP:0003811)1.67633437
160Hypertriglyceridemia (HP:0002155)1.67288534
161Abnormal tarsal ossification (HP:0008369)1.67161947
162Delusions (HP:0000746)1.66254936
163Abnormal enzyme/coenzyme activity (HP:0012379)1.65667082
164Fasciculations (HP:0002380)1.65645090
165Atelectasis (HP:0100750)1.65329192
166Myopathic facies (HP:0002058)1.63395175
167Recurrent gram-negative bacterial infections (HP:0005420)1.62056308
168Stridor (HP:0010307)1.61033295
169Distal lower limb muscle weakness (HP:0009053)1.59869895
170Nephritis (HP:0000123)1.59193033
171Abnormality of macrophages (HP:0004311)1.59160798
172Decreased activity of mitochondrial respiratory chain (HP:0008972)1.57314505
173Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.57314505
174Short nail (HP:0001799)1.56643215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.61030044
2STK393.66813703
3OXSR13.44342745
4IRAK33.20997143
5EPHB13.15643530
6TESK13.12704573
7SMG12.90127033
8ERN12.86645118
9WNK42.58317286
10RIPK12.51997438
11SIK12.33948868
12FGFR42.23540854
13MAPK152.17415421
14EPHA22.14391414
15MUSK2.11426432
16PIM22.04220855
17PIK3CG1.95867629
18CDK121.83891226
19PRPF4B1.83210535
20MET1.75784180
21TAOK21.66838048
22DDR21.66381517
23TAOK31.63518715
24INSRR1.62985741
25PKN11.57522129
26EEF2K1.47851136
27PRKD31.46015016
28TYRO31.38508879
29CDK191.35458415
30MST1R1.29583420
31BRAF1.27017259
32TRIB31.23509120
33PBK1.22986294
34LATS21.21301190
35TAOK11.17452542
36MAPKAPK51.15931632
37CAMK2G1.14959081
38MAP2K21.13331011
39PIK3CA1.12574206
40TIE11.12540249
41PHKG11.09175814
42PHKG21.09175814
43MAPKAPK31.08490176
44MAP3K31.05407539
45STK161.04394591
46MYLK1.04200999
47MAP3K131.04138648
48NME21.00813978
49PAK41.00397254
50TBK11.00089162
51PINK10.99999907
52FGFR20.98434879
53TYK20.98125311
54TGFBR20.97633490
55TESK20.96900194
56BCR0.96328399
57PDGFRA0.95742926
58CAMK2D0.95417243
59ABL20.94223757
60IRAK10.93943678
61MAP3K110.93115548
62MST40.92148653
63MAP2K30.90573372
64CSNK1G30.89949915
65FLT30.89055851
66MAP3K10.88632250
67KDR0.88253379
68SIK20.86482799
69CAMK2B0.85886231
70DAPK10.85085757
71KSR20.84457404
72CSNK1G10.83692079
73AURKA0.81788972
74PDPK10.80104193
75VRK20.79191066
76MAP4K10.79033760
77CDK11A0.78392428
78SCYL20.78028321
79DAPK20.77101112
80OBSCN0.76943120
81CSF1R0.76690620
82IRAK20.75950096
83SGK4940.75299603
84SGK2230.75299603
85NTRK10.73259923
86CDC42BPA0.73043219
87DAPK30.72777261
88GRK10.72482751
89MAP3K70.71802197
90PTK60.71083992
91CDK70.71040520
92GSK3A0.69594158
93MARK20.68958333
94MTOR0.68250284
95CSK0.67412752
96CDK150.67377652
97CSNK1A1L0.67165706
98WNK30.67060050
99PRKD10.66833260
100MAP3K80.66327906
101MAP3K20.65598094
102MAPK120.65485571
103MOS0.64989591
104ILK0.63970178
105GRK60.63803396
106JAK20.63318892
107RPS6KA20.63263498
108ERBB40.63104666
109MAPK40.62572084
110PRKCQ0.61757406
111LRRK20.61094574
112LIMK10.60947475
113BRSK10.60718311
114CDK140.60575798
115MATK0.60337774
116KIT0.60207571
117EPHA40.59172692
118ARAF0.58623923
119PRKD20.58146613
120CDK180.57419066
121CAMK1D0.56951633
122FGR0.56838056
123PRKAA20.56516938
124MAP3K90.55690747
125LMTK20.54880262
126PRKG20.53978541
127MAPK110.52272384
128CDK40.51839499
129PRKCH0.50583358
130ITK0.49435945
131ICK0.48918572
132GRK50.48744495
133IKBKB0.48336371
134IKBKE0.48164403
135DYRK1B0.47932560
136ROCK20.47415753
137RPS6KC10.46890144
138RPS6KL10.46890144
139MAPK70.46758416
140RIPK40.46247698
141CSNK1G20.45683156
142BMX0.44854739
143PTK20.44678055
144PRKACG0.44399374
145CAMKK10.44343768
146PDK10.43983861
147AKT20.43205935
148ZAP700.43052295
149STK380.43040048
150WNK10.42662601
151BLK0.42035104
152PKN20.41278246
153EPHA30.40848943
154MAP3K140.39972244
155PAK10.35484574
156EPHB20.34903148
157MAP2K60.34480093
158PAK60.31794281
159PRKCI0.26098996
160RPS6KA10.25475108
161CAMK1G0.24151084
162CDK90.22678276
163RPS6KB20.22601032
164RPS6KA60.21867686
165CSNK2A20.21410590

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.48334298
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.94547437
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.72670254
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72609985
5Nitrogen metabolism_Homo sapiens_hsa009102.69961940
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48790826
7Fatty acid elongation_Homo sapiens_hsa000622.48326378
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47480659
9Fatty acid degradation_Homo sapiens_hsa000712.42393833
10Propanoate metabolism_Homo sapiens_hsa006402.34605946
11Arginine biosynthesis_Homo sapiens_hsa002202.32888350
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31306107
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29016492
14Butanoate metabolism_Homo sapiens_hsa006502.28993985
15Tryptophan metabolism_Homo sapiens_hsa003802.28461240
16Peroxisome_Homo sapiens_hsa041462.18863401
17Sulfur metabolism_Homo sapiens_hsa009202.10744852
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05625131
19Histidine metabolism_Homo sapiens_hsa003402.01791024
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01122890
21Fatty acid metabolism_Homo sapiens_hsa012121.99963499
22Complement and coagulation cascades_Homo sapiens_hsa046101.98954610
23Steroid biosynthesis_Homo sapiens_hsa001001.91238087
24PPAR signaling pathway_Homo sapiens_hsa033201.88194720
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77570800
26Chemical carcinogenesis_Homo sapiens_hsa052041.75450242
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.68458508
28beta-Alanine metabolism_Homo sapiens_hsa004101.67633544
29Pyruvate metabolism_Homo sapiens_hsa006201.62641103
30Folate biosynthesis_Homo sapiens_hsa007901.61404280
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51255869
32Ribosome_Homo sapiens_hsa030101.46857730
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42868869
34Synaptic vesicle cycle_Homo sapiens_hsa047211.40488016
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39023227
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36869349
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35543714
38Retinol metabolism_Homo sapiens_hsa008301.33860591
39Staphylococcus aureus infection_Homo sapiens_hsa051501.32428560
40Bile secretion_Homo sapiens_hsa049761.32051645
41Caffeine metabolism_Homo sapiens_hsa002321.31126613
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29605522
43Arginine and proline metabolism_Homo sapiens_hsa003301.28875971
44Phenylalanine metabolism_Homo sapiens_hsa003601.26664933
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.25996046
46Tyrosine metabolism_Homo sapiens_hsa003501.24310884
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20128126
48Oxidative phosphorylation_Homo sapiens_hsa001901.18019934
49Carbon metabolism_Homo sapiens_hsa012001.17273571
50N-Glycan biosynthesis_Homo sapiens_hsa005101.15840328
51Fat digestion and absorption_Homo sapiens_hsa049751.14844294
52Starch and sucrose metabolism_Homo sapiens_hsa005001.14200659
53ABC transporters_Homo sapiens_hsa020101.13508064
54Sulfur relay system_Homo sapiens_hsa041221.10137664
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09511623
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03382945
57Bladder cancer_Homo sapiens_hsa052191.03104469
58Selenocompound metabolism_Homo sapiens_hsa004501.02949134
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02317579
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.01852507
61Glutathione metabolism_Homo sapiens_hsa004800.99457453
62Biosynthesis of amino acids_Homo sapiens_hsa012300.96980528
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.96323672
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.95248378
65Vitamin digestion and absorption_Homo sapiens_hsa049770.92607305
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89559755
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.87041371
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86109852
69Glycerolipid metabolism_Homo sapiens_hsa005610.85905461
70Vitamin B6 metabolism_Homo sapiens_hsa007500.85571193
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84977833
72Parkinsons disease_Homo sapiens_hsa050120.82921917
73Protein export_Homo sapiens_hsa030600.80283597
74Pertussis_Homo sapiens_hsa051330.75722056
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69266247
76Metabolic pathways_Homo sapiens_hsa011000.68887179
77Renin-angiotensin system_Homo sapiens_hsa046140.68490790
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65991190
79Notch signaling pathway_Homo sapiens_hsa043300.65250426
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63893127
81Pyrimidine metabolism_Homo sapiens_hsa002400.62607440
82Base excision repair_Homo sapiens_hsa034100.62391375
83Alzheimers disease_Homo sapiens_hsa050100.62261132
84VEGF signaling pathway_Homo sapiens_hsa043700.61332054
85Pentose phosphate pathway_Homo sapiens_hsa000300.60427513
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60246869
87Linoleic acid metabolism_Homo sapiens_hsa005910.59732796
88Salmonella infection_Homo sapiens_hsa051320.55274059
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54727566
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54547702
91Endocytosis_Homo sapiens_hsa041440.51951134
92Fatty acid biosynthesis_Homo sapiens_hsa000610.50301409
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45937362
94Acute myeloid leukemia_Homo sapiens_hsa052210.45735247
95Ether lipid metabolism_Homo sapiens_hsa005650.43412806
96Hepatitis C_Homo sapiens_hsa051600.42764284
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42091552
98Fructose and mannose metabolism_Homo sapiens_hsa000510.41758412
99HIF-1 signaling pathway_Homo sapiens_hsa040660.41104261
100Insulin signaling pathway_Homo sapiens_hsa049100.40578154
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37417953
102DNA replication_Homo sapiens_hsa030300.36143286
103Thyroid hormone synthesis_Homo sapiens_hsa049180.35750137
104Lysosome_Homo sapiens_hsa041420.35683499
105AMPK signaling pathway_Homo sapiens_hsa041520.35348850
106Galactose metabolism_Homo sapiens_hsa000520.32758275
107Prion diseases_Homo sapiens_hsa050200.31800114
108Lysine degradation_Homo sapiens_hsa003100.31577948
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31237635
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.30567491
111Other glycan degradation_Homo sapiens_hsa005110.30394779
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30015151
113Apoptosis_Homo sapiens_hsa042100.28786618
114Shigellosis_Homo sapiens_hsa051310.28438941
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26474610
116Arachidonic acid metabolism_Homo sapiens_hsa005900.26143516
117Phagosome_Homo sapiens_hsa041450.24282743
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.20994561
119Huntingtons disease_Homo sapiens_hsa050160.20062371
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.18532766
121Insulin resistance_Homo sapiens_hsa049310.14870362
122Collecting duct acid secretion_Homo sapiens_hsa049660.14398563
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11292513
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10586051
125Sphingolipid metabolism_Homo sapiens_hsa006000.10055950
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09166593
127Cardiac muscle contraction_Homo sapiens_hsa042600.08385335
128Mineral absorption_Homo sapiens_hsa049780.05283277
129Regulation of autophagy_Homo sapiens_hsa041400.00327194
130Pancreatic secretion_Homo sapiens_hsa04972-0.0386464
131Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0358030
132Vibrio cholerae infection_Homo sapiens_hsa05110-0.0319553
133Protein digestion and absorption_Homo sapiens_hsa04974-0.0125046

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