

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit biogenesis (GO:0042274) | 7.34128479 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.90621747 |
| 3 | viral transcription (GO:0019083) | 6.67596621 |
| 4 | translational termination (GO:0006415) | 6.52077212 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 6.35422758 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.35422758 |
| 7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.84125033 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 5.74689843 |
| 9 | protein targeting to ER (GO:0045047) | 5.73189872 |
| 10 | ribosomal large subunit biogenesis (GO:0042273) | 5.68955235 |
| 11 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.49417566 |
| 12 | maturation of SSU-rRNA (GO:0030490) | 5.47803200 |
| 13 | translational elongation (GO:0006414) | 5.44492069 |
| 14 | protein localization to endoplasmic reticulum (GO:0070972) | 5.39509466 |
| 15 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.28237521 |
| 16 | respiratory electron transport chain (GO:0022904) | 5.14278996 |
| 17 | electron transport chain (GO:0022900) | 5.06872292 |
| 18 | ribosomal small subunit assembly (GO:0000028) | 5.02243862 |
| 19 | viral life cycle (GO:0019058) | 4.97495563 |
| 20 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.96479712 |
| 21 | proteasome assembly (GO:0043248) | 4.91265410 |
| 22 | cellular protein complex disassembly (GO:0043624) | 4.88407580 |
| 23 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.77863553 |
| 24 | chaperone-mediated protein transport (GO:0072321) | 4.71597642 |
| 25 | translational initiation (GO:0006413) | 4.71252860 |
| 26 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.49615181 |
| 27 | termination of RNA polymerase III transcription (GO:0006386) | 4.49615181 |
| 28 | protein complex biogenesis (GO:0070271) | 4.49489414 |
| 29 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.41585527 |
| 30 | NADH dehydrogenase complex assembly (GO:0010257) | 4.41585527 |
| 31 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.41585527 |
| 32 | translation (GO:0006412) | 4.38036679 |
| 33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.37976799 |
| 34 | DNA replication checkpoint (GO:0000076) | 4.21330048 |
| 35 | regulation of mitochondrial translation (GO:0070129) | 4.11688836 |
| 36 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.06391743 |
| 37 | protein complex disassembly (GO:0043241) | 3.98862962 |
| 38 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.94890158 |
| 39 | rRNA modification (GO:0000154) | 3.93863877 |
| 40 | cellular component biogenesis (GO:0044085) | 3.90135475 |
| 41 | protein targeting to membrane (GO:0006612) | 3.79376707 |
| 42 | macromolecular complex disassembly (GO:0032984) | 3.79296389 |
| 43 | rRNA processing (GO:0006364) | 3.71461051 |
| 44 | rRNA methylation (GO:0031167) | 3.66769622 |
| 45 | protein targeting to mitochondrion (GO:0006626) | 3.64359769 |
| 46 | rRNA metabolic process (GO:0016072) | 3.58303849 |
| 47 | pseudouridine synthesis (GO:0001522) | 3.56477212 |
| 48 | ATP biosynthetic process (GO:0006754) | 3.54651857 |
| 49 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.52145134 |
| 50 | respiratory chain complex IV assembly (GO:0008535) | 3.50236987 |
| 51 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.49901153 |
| 52 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.44765351 |
| 53 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.43720346 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.43038510 |
| 55 | protein neddylation (GO:0045116) | 3.34360586 |
| 56 | establishment of protein localization to mitochondrion (GO:0072655) | 3.32093547 |
| 57 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.31886554 |
| 58 | mRNA catabolic process (GO:0006402) | 3.31246446 |
| 59 | protein localization to mitochondrion (GO:0070585) | 3.29867134 |
| 60 | hydrogen ion transmembrane transport (GO:1902600) | 3.26656507 |
| 61 | protein-cofactor linkage (GO:0018065) | 3.26354767 |
| 62 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.15881083 |
| 63 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.14504388 |
| 64 | oxidative phosphorylation (GO:0006119) | 3.14389339 |
| 65 | RNA catabolic process (GO:0006401) | 3.11286014 |
| 66 | GTP biosynthetic process (GO:0006183) | 3.09103895 |
| 67 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.08454117 |
| 68 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.04328047 |
| 69 | negative regulation of ligase activity (GO:0051352) | 3.04328047 |
| 70 | nucleoside transmembrane transport (GO:1901642) | 2.97685008 |
| 71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.97356195 |
| 72 | mitochondrial transport (GO:0006839) | 2.95343745 |
| 73 | DNA deamination (GO:0045006) | 2.93759905 |
| 74 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.93512205 |
| 75 | intracellular protein transmembrane import (GO:0044743) | 2.91992637 |
| 76 | spliceosomal snRNP assembly (GO:0000387) | 2.91317659 |
| 77 | proton transport (GO:0015992) | 2.89878622 |
| 78 | base-excision repair, AP site formation (GO:0006285) | 2.85908295 |
| 79 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.85534859 |
| 80 | hydrogen transport (GO:0006818) | 2.84965405 |
| 81 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.82048815 |
| 82 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.81626401 |
| 83 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.79906929 |
| 84 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.79343262 |
| 85 | aerobic respiration (GO:0009060) | 2.78519096 |
| 86 | CENP-A containing nucleosome assembly (GO:0034080) | 2.78389809 |
| 87 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.77657158 |
| 88 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.77657158 |
| 89 | chromatin remodeling at centromere (GO:0031055) | 2.75560727 |
| 90 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.74828553 |
| 91 | regulation of oxidative phosphorylation (GO:0002082) | 2.74089962 |
| 92 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.73337983 |
| 93 | protein targeting (GO:0006605) | 2.72333157 |
| 94 | UTP biosynthetic process (GO:0006228) | 2.71170620 |
| 95 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.69015664 |
| 96 | ncRNA processing (GO:0034470) | 2.68369639 |
| 97 | establishment of protein localization to membrane (GO:0090150) | 2.67125618 |
| 98 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.63472766 |
| 99 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.62261361 |
| 100 | vitamin biosynthetic process (GO:0009110) | 2.60900822 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.94473564 |
| 2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.81077526 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.46251142 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.29308275 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.94953209 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.84213025 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.49264041 |
| 8 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.21424438 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.18656509 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.96817511 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.92114700 |
| 12 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.89635987 |
| 13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.82601175 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.82534479 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.71334587 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.68243928 |
| 17 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.60238851 |
| 18 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.57980622 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.48833038 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.42754557 |
| 21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.41371339 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.38885073 |
| 23 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.30241777 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.25205159 |
| 25 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.19628136 |
| 26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.16352161 |
| 27 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.16130479 |
| 28 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.15397121 |
| 29 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.14109975 |
| 30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.12249507 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.07603973 |
| 32 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.07144181 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.04840041 |
| 34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.98550760 |
| 35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.83295793 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.73908183 |
| 37 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.67625467 |
| 38 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.66105457 |
| 39 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.63795149 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61435742 |
| 41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.60456016 |
| 42 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.58806311 |
| 43 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.51344933 |
| 44 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.48833497 |
| 45 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.48749979 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47295278 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.46195469 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45227767 |
| 49 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.43885192 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.42559970 |
| 51 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.37237099 |
| 52 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.35931030 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33324747 |
| 54 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.31693409 |
| 55 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.30592287 |
| 56 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.26688952 |
| 57 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.26203782 |
| 58 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.25292820 |
| 59 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.24588503 |
| 60 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.24340921 |
| 61 | EWS_26573619_Chip-Seq_HEK293_Human | 1.20550485 |
| 62 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.16755554 |
| 63 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14432623 |
| 64 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.14132846 |
| 65 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.12166253 |
| 66 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.11988528 |
| 67 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.09310273 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06431185 |
| 69 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.05542921 |
| 70 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02278374 |
| 71 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.00863750 |
| 72 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.99675989 |
| 73 | VDR_22108803_ChIP-Seq_LS180_Human | 0.97860153 |
| 74 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.97747122 |
| 75 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95969644 |
| 76 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.95635633 |
| 77 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.94150214 |
| 78 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.92383907 |
| 79 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91158779 |
| 80 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.90991849 |
| 81 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.87959057 |
| 82 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.85970324 |
| 83 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.85890389 |
| 84 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.84765961 |
| 85 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.83877181 |
| 86 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.81466573 |
| 87 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.81466573 |
| 88 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.80936215 |
| 89 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.79872437 |
| 90 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.79650044 |
| 91 | GATA1_22025678_ChIP-Seq_K562_Human | 0.78359657 |
| 92 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.76467051 |
| 93 | AR_20517297_ChIP-Seq_VCAP_Human | 0.76452469 |
| 94 | GATA3_26560356_Chip-Seq_TH2_Human | 0.73942062 |
| 95 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.71176479 |
| 96 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.70747956 |
| 97 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.70656197 |
| 98 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.69814527 |
| 99 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.69722781 |
| 100 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.68466105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 5.63892828 |
| 2 | MP0009379_abnormal_foot_pigmentation | 4.38057638 |
| 3 | MP0008875_abnormal_xenobiotic_pharmacok | 3.43507245 |
| 4 | MP0006036_abnormal_mitochondrial_physio | 2.93972947 |
| 5 | MP0002139_abnormal_hepatobiliary_system | 2.82945957 |
| 6 | MP0003693_abnormal_embryo_hatching | 2.74464094 |
| 7 | MP0003195_calcinosis | 2.46420517 |
| 8 | MP0008058_abnormal_DNA_repair | 2.38406758 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.31712888 |
| 10 | MP0005085_abnormal_gallbladder_physiolo | 2.23457856 |
| 11 | MP0003186_abnormal_redox_activity | 2.18749172 |
| 12 | MP0010094_abnormal_chromosome_stability | 2.15981917 |
| 13 | MP0002837_dystrophic_cardiac_calcinosis | 2.09506305 |
| 14 | MP0006292_abnormal_olfactory_placode | 2.06009441 |
| 15 | MP0002277_abnormal_respiratory_mucosa | 2.04667339 |
| 16 | MP0005332_abnormal_amino_acid | 2.01017644 |
| 17 | MP0001835_abnormal_antigen_presentation | 1.97590822 |
| 18 | MP0003111_abnormal_nucleus_morphology | 1.92653940 |
| 19 | MP0005360_urolithiasis | 1.89785448 |
| 20 | MP0009697_abnormal_copulation | 1.89095118 |
| 21 | MP0003786_premature_aging | 1.88197474 |
| 22 | MP0001764_abnormal_homeostasis | 1.85083065 |
| 23 | MP0005174_abnormal_tail_pigmentation | 1.80069873 |
| 24 | MP0003303_peritoneal_inflammation | 1.78023573 |
| 25 | MP0003718_maternal_effect | 1.74655647 |
| 26 | MP0003252_abnormal_bile_duct | 1.72756755 |
| 27 | MP0010386_abnormal_urinary_bladder | 1.72562797 |
| 28 | MP0002160_abnormal_reproductive_system | 1.67928055 |
| 29 | MP0006072_abnormal_retinal_apoptosis | 1.65170267 |
| 30 | MP0003077_abnormal_cell_cycle | 1.61061452 |
| 31 | MP0005084_abnormal_gallbladder_morpholo | 1.60205714 |
| 32 | MP0008007_abnormal_cellular_replicative | 1.59319912 |
| 33 | MP0001986_abnormal_taste_sensitivity | 1.58232115 |
| 34 | MP0005671_abnormal_response_to | 1.53823746 |
| 35 | MP0004019_abnormal_vitamin_homeostasis | 1.52002642 |
| 36 | MP0002876_abnormal_thyroid_physiology | 1.48248723 |
| 37 | MP0000516_abnormal_urinary_system | 1.44925197 |
| 38 | MP0005367_renal/urinary_system_phenotyp | 1.44925197 |
| 39 | MP0005365_abnormal_bile_salt | 1.44176487 |
| 40 | MP0006035_abnormal_mitochondrial_morpho | 1.40848441 |
| 41 | MP0005389_reproductive_system_phenotype | 1.38239837 |
| 42 | MP0002148_abnormal_hypersensitivity_rea | 1.36962189 |
| 43 | MP0009785_altered_susceptibility_to | 1.34692116 |
| 44 | MP0000685_abnormal_immune_system | 1.34255303 |
| 45 | MP0008872_abnormal_physiological_respon | 1.34171719 |
| 46 | MP0002163_abnormal_gland_morphology | 1.32869267 |
| 47 | MP0005636_abnormal_mineral_homeostasis | 1.32786324 |
| 48 | MP0009333_abnormal_splenocyte_physiolog | 1.27560137 |
| 49 | MP0001756_abnormal_urination | 1.26890736 |
| 50 | MP0000372_irregular_coat_pigmentation | 1.24636295 |
| 51 | MP0002938_white_spotting | 1.20741455 |
| 52 | MP0003136_yellow_coat_color | 1.15013677 |
| 53 | MP0001800_abnormal_humoral_immune | 1.11268180 |
| 54 | MP0005379_endocrine/exocrine_gland_phen | 1.10822166 |
| 55 | MP0002132_abnormal_respiratory_system | 1.09791714 |
| 56 | MP0003315_abnormal_perineum_morphology | 1.07094778 |
| 57 | MP0000538_abnormal_urinary_bladder | 1.05897126 |
| 58 | MP0001919_abnormal_reproductive_system | 1.04512831 |
| 59 | MP0004142_abnormal_muscle_tone | 1.00769503 |
| 60 | MP0008873_increased_physiological_sensi | 1.00619393 |
| 61 | MP0001188_hyperpigmentation | 1.00024257 |
| 62 | MP0009046_muscle_twitch | 0.98313737 |
| 63 | MP0008995_early_reproductive_senescence | 0.96635931 |
| 64 | MP0001881_abnormal_mammary_gland | 0.94504802 |
| 65 | MP0009764_decreased_sensitivity_to | 0.94311607 |
| 66 | MP0005075_abnormal_melanosome_morpholog | 0.92477727 |
| 67 | MP0001790_abnormal_immune_system | 0.91014480 |
| 68 | MP0005387_immune_system_phenotype | 0.91014480 |
| 69 | MP0003011_delayed_dark_adaptation | 0.90453389 |
| 70 | MP0008469_abnormal_protein_level | 0.89633246 |
| 71 | MP0002452_abnormal_antigen_presenting | 0.88064895 |
| 72 | MP0001666_abnormal_nutrient_absorption | 0.87954590 |
| 73 | MP0005319_abnormal_enzyme/_coenzyme | 0.85674653 |
| 74 | MP0009765_abnormal_xenobiotic_induced | 0.84239658 |
| 75 | MP0002723_abnormal_immune_serum | 0.83795829 |
| 76 | MP0001905_abnormal_dopamine_level | 0.83510188 |
| 77 | MP0005266_abnormal_metabolism | 0.82212848 |
| 78 | MP0001845_abnormal_inflammatory_respons | 0.81538061 |
| 79 | MP0001346_abnormal_lacrimal_gland | 0.81249803 |
| 80 | MP0002638_abnormal_pupillary_reflex | 0.80568024 |
| 81 | MP0009643_abnormal_urine_homeostasis | 0.80159706 |
| 82 | MP0001944_abnormal_pancreas_morphology | 0.79302295 |
| 83 | MP0002138_abnormal_hepatobiliary_system | 0.79125982 |
| 84 | MP0002693_abnormal_pancreas_physiology | 0.78511396 |
| 85 | MP0005000_abnormal_immune_tolerance | 0.77402418 |
| 86 | MP0002095_abnormal_skin_pigmentation | 0.76673410 |
| 87 | MP0004043_abnormal_pH_regulation | 0.75506824 |
| 88 | MP0005646_abnormal_pituitary_gland | 0.74125967 |
| 89 | MP0002019_abnormal_tumor_incidence | 0.72637519 |
| 90 | MP0008057_abnormal_DNA_replication | 0.71708051 |
| 91 | MP0000313_abnormal_cell_death | 0.70594614 |
| 92 | MP0000490_abnormal_crypts_of | 0.70523773 |
| 93 | MP0008932_abnormal_embryonic_tissue | 0.70312731 |
| 94 | MP0010155_abnormal_intestine_physiology | 0.69610901 |
| 95 | MP0005408_hypopigmentation | 0.67544740 |
| 96 | MP0009763_increased_sensitivity_to | 0.67484410 |
| 97 | MP0002090_abnormal_vision | 0.67112263 |
| 98 | MP0000013_abnormal_adipose_tissue | 0.67031090 |
| 99 | MP0002736_abnormal_nociception_after | 0.66388299 |
| 100 | MP0001819_abnormal_immune_cell | 0.65540682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.05765169 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.68038106 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.57060510 |
| 4 | 3-Methylglutaconic aciduria (HP:0003535) | 4.54178506 |
| 5 | Acute encephalopathy (HP:0006846) | 4.31860784 |
| 6 | Macrocytic anemia (HP:0001972) | 4.30580882 |
| 7 | Increased CSF lactate (HP:0002490) | 4.27786709 |
| 8 | Progressive macrocephaly (HP:0004481) | 4.25230914 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.24195153 |
| 10 | Abnormal number of erythroid precursors (HP:0012131) | 4.23784877 |
| 11 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.03375763 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.97225345 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.96293454 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.96293454 |
| 15 | Hepatocellular necrosis (HP:0001404) | 3.82352310 |
| 16 | Hepatic necrosis (HP:0002605) | 3.68563825 |
| 17 | Renal Fanconi syndrome (HP:0001994) | 3.67953461 |
| 18 | Abnormality of alanine metabolism (HP:0010916) | 3.53657572 |
| 19 | Hyperalaninemia (HP:0003348) | 3.53657572 |
| 20 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.53657572 |
| 21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.50365041 |
| 22 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.49080400 |
| 23 | Cerebral edema (HP:0002181) | 3.37506252 |
| 24 | Reticulocytopenia (HP:0001896) | 3.34153131 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 3.29755553 |
| 26 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.24365912 |
| 27 | Pallor (HP:0000980) | 3.20661773 |
| 28 | Congenital, generalized hypertrichosis (HP:0004540) | 3.19996279 |
| 29 | Exertional dyspnea (HP:0002875) | 3.12036835 |
| 30 | Increased serum lactate (HP:0002151) | 2.98276619 |
| 31 | Lactic acidosis (HP:0003128) | 2.97932594 |
| 32 | Abnormality of methionine metabolism (HP:0010901) | 2.96999898 |
| 33 | Increased muscle lipid content (HP:0009058) | 2.95149110 |
| 34 | Methylmalonic acidemia (HP:0002912) | 2.92861263 |
| 35 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.88772821 |
| 36 | Exercise intolerance (HP:0003546) | 2.73056868 |
| 37 | Abnormality of serum amino acid levels (HP:0003112) | 2.68155598 |
| 38 | Type I transferrin isoform profile (HP:0003642) | 2.63848272 |
| 39 | Respiratory failure (HP:0002878) | 2.61278841 |
| 40 | Methylmalonic aciduria (HP:0012120) | 2.58353716 |
| 41 | Aplastic anemia (HP:0001915) | 2.56612139 |
| 42 | Lethargy (HP:0001254) | 2.55700690 |
| 43 | Megaloblastic anemia (HP:0001889) | 2.54787925 |
| 44 | Abnormality of homocysteine metabolism (HP:0010919) | 2.54638824 |
| 45 | Homocystinuria (HP:0002156) | 2.54638824 |
| 46 | Glycosuria (HP:0003076) | 2.53221776 |
| 47 | Abnormality of urine glucose concentration (HP:0011016) | 2.53221776 |
| 48 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.52657385 |
| 49 | Generalized aminoaciduria (HP:0002909) | 2.46679492 |
| 50 | Abnormality of renal resorption (HP:0011038) | 2.44782905 |
| 51 | Respiratory difficulties (HP:0002880) | 2.44251322 |
| 52 | Oral leukoplakia (HP:0002745) | 2.43075428 |
| 53 | Reduced antithrombin III activity (HP:0001976) | 2.39828604 |
| 54 | Prolonged partial thromboplastin time (HP:0003645) | 2.33469950 |
| 55 | Optic disc pallor (HP:0000543) | 2.27454300 |
| 56 | Birth length less than 3rd percentile (HP:0003561) | 2.25437577 |
| 57 | Leukodystrophy (HP:0002415) | 2.25278971 |
| 58 | Testicular atrophy (HP:0000029) | 2.16671420 |
| 59 | Rectovaginal fistula (HP:0000143) | 2.16652035 |
| 60 | Rectal fistula (HP:0100590) | 2.16652035 |
| 61 | Metabolic acidosis (HP:0001942) | 2.14919751 |
| 62 | Microretrognathia (HP:0000308) | 2.14407584 |
| 63 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.12099438 |
| 64 | Abnormality of placental membranes (HP:0011409) | 2.11776294 |
| 65 | Amniotic constriction ring (HP:0009775) | 2.11776294 |
| 66 | Cleft eyelid (HP:0000625) | 2.10563575 |
| 67 | Paralysis (HP:0003470) | 2.00623809 |
| 68 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.00221236 |
| 69 | Hyperphosphaturia (HP:0003109) | 2.00169304 |
| 70 | Absent thumb (HP:0009777) | 1.99538079 |
| 71 | Increased serum pyruvate (HP:0003542) | 1.99210372 |
| 72 | Abnormality of vitamin B metabolism (HP:0004340) | 1.98897846 |
| 73 | Abnormal protein glycosylation (HP:0012346) | 1.96632932 |
| 74 | Abnormal glycosylation (HP:0012345) | 1.96632932 |
| 75 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.96632932 |
| 76 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.96632932 |
| 77 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.96374821 |
| 78 | Poor head control (HP:0002421) | 1.94514321 |
| 79 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.94093559 |
| 80 | Dicarboxylic aciduria (HP:0003215) | 1.94093559 |
| 81 | Nausea (HP:0002018) | 1.87879968 |
| 82 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.85798932 |
| 83 | Vaginal fistula (HP:0004320) | 1.82532716 |
| 84 | Anorexia (HP:0002039) | 1.81201208 |
| 85 | CNS demyelination (HP:0007305) | 1.81167288 |
| 86 | Hyperglycinemia (HP:0002154) | 1.80489932 |
| 87 | Intestinal fistula (HP:0100819) | 1.80147620 |
| 88 | Renal tubular dysfunction (HP:0000124) | 1.80142470 |
| 89 | IgG deficiency (HP:0004315) | 1.78935623 |
| 90 | Tinnitus (HP:0000360) | 1.78817935 |
| 91 | Hypobetalipoproteinemia (HP:0003563) | 1.77717385 |
| 92 | Decreased subcutaneous fat (HP:0001002) | 1.77687412 |
| 93 | Parakeratosis (HP:0001036) | 1.77469762 |
| 94 | Degeneration of anterior horn cells (HP:0002398) | 1.76482662 |
| 95 | Abnormality of the anterior horn cell (HP:0006802) | 1.76482662 |
| 96 | Pancreatic cysts (HP:0001737) | 1.73518249 |
| 97 | Opisthotonus (HP:0002179) | 1.72500236 |
| 98 | Abnormal urine phosphate concentration (HP:0012599) | 1.71559345 |
| 99 | Confusion (HP:0001289) | 1.71087308 |
| 100 | Sensory axonal neuropathy (HP:0003390) | 1.69978310 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TLK1 | 5.88925559 |
| 2 | BUB1 | 4.63991761 |
| 3 | STK16 | 4.24211411 |
| 4 | NME2 | 3.32552369 |
| 5 | VRK2 | 3.23694302 |
| 6 | MST4 | 2.79798352 |
| 7 | ZAK | 2.52856046 |
| 8 | NUAK1 | 2.01685209 |
| 9 | CDK19 | 1.94170129 |
| 10 | EIF2AK1 | 1.92526907 |
| 11 | TESK2 | 1.79521630 |
| 12 | ADRBK2 | 1.74381112 |
| 13 | NME1 | 1.73995225 |
| 14 | MAP3K12 | 1.73943301 |
| 15 | CDC7 | 1.70981207 |
| 16 | SRPK1 | 1.69984322 |
| 17 | PDK2 | 1.64136525 |
| 18 | VRK1 | 1.57884116 |
| 19 | EIF2AK3 | 1.56707529 |
| 20 | WNK4 | 1.53387483 |
| 21 | PLK4 | 1.49528903 |
| 22 | IKBKB | 1.35309539 |
| 23 | BMPR1B | 1.24230654 |
| 24 | BLK | 1.22481720 |
| 25 | FRK | 1.21715416 |
| 26 | PHKG2 | 1.17997746 |
| 27 | PHKG1 | 1.17997746 |
| 28 | INSRR | 1.17092362 |
| 29 | GRK6 | 1.14249896 |
| 30 | PBK | 1.11825071 |
| 31 | GRK1 | 1.10624872 |
| 32 | MYLK | 1.08937219 |
| 33 | ABL2 | 1.06068584 |
| 34 | BCKDK | 1.05822309 |
| 35 | OXSR1 | 1.02527167 |
| 36 | BMPR2 | 0.98135222 |
| 37 | ILK | 0.90622822 |
| 38 | PLK1 | 0.89856396 |
| 39 | TAOK3 | 0.86050703 |
| 40 | MUSK | 0.83411312 |
| 41 | STK3 | 0.83107636 |
| 42 | AURKB | 0.82684874 |
| 43 | DYRK2 | 0.82592446 |
| 44 | PLK3 | 0.82443508 |
| 45 | RPS6KA5 | 0.81562092 |
| 46 | CCNB1 | 0.81420424 |
| 47 | TNIK | 0.80062308 |
| 48 | MAP2K6 | 0.77160950 |
| 49 | NEK1 | 0.77134961 |
| 50 | RPS6KB2 | 0.76049206 |
| 51 | SCYL2 | 0.75638605 |
| 52 | PASK | 0.73586246 |
| 53 | CHEK2 | 0.73150285 |
| 54 | CSNK2A1 | 0.72996603 |
| 55 | WNK3 | 0.72572295 |
| 56 | MATK | 0.71399058 |
| 57 | DYRK3 | 0.71013278 |
| 58 | TTK | 0.70547189 |
| 59 | CDK8 | 0.69952150 |
| 60 | MAP4K2 | 0.69359428 |
| 61 | CSNK2A2 | 0.68109533 |
| 62 | ARAF | 0.68096633 |
| 63 | ACVR1B | 0.65174717 |
| 64 | RIPK4 | 0.64963322 |
| 65 | ATR | 0.64287379 |
| 66 | STK24 | 0.64073470 |
| 67 | LYN | 0.63012327 |
| 68 | NEK2 | 0.61575426 |
| 69 | TXK | 0.59398165 |
| 70 | TEC | 0.58507097 |
| 71 | MKNK2 | 0.56905800 |
| 72 | MAP2K3 | 0.56878917 |
| 73 | TRIM28 | 0.55541617 |
| 74 | SYK | 0.54430649 |
| 75 | CSNK1G3 | 0.54328078 |
| 76 | TAF1 | 0.53407137 |
| 77 | MAP2K2 | 0.53032921 |
| 78 | MAPK15 | 0.50858213 |
| 79 | PIM2 | 0.50726012 |
| 80 | MKNK1 | 0.50028502 |
| 81 | ADRBK1 | 0.49364036 |
| 82 | STK39 | 0.48795554 |
| 83 | EIF2AK2 | 0.47452216 |
| 84 | DAPK3 | 0.46461424 |
| 85 | ERN1 | 0.46221827 |
| 86 | GRK7 | 0.44299802 |
| 87 | PRKCI | 0.44266350 |
| 88 | IKBKE | 0.43873783 |
| 89 | CSNK1G1 | 0.43221396 |
| 90 | CDK3 | 0.43164568 |
| 91 | PIM1 | 0.43084574 |
| 92 | MAPKAPK3 | 0.39118600 |
| 93 | BRSK2 | 0.38546778 |
| 94 | NEK9 | 0.37525774 |
| 95 | CDK7 | 0.36075417 |
| 96 | MARK3 | 0.35488624 |
| 97 | STK4 | 0.31134021 |
| 98 | MAPKAPK5 | 0.30089152 |
| 99 | CDK4 | 0.29741716 |
| 100 | CHEK1 | 0.26537115 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.32924317 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.18262735 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.39056554 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.38234255 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.82498231 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.67084782 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.37117276 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.22374455 |
| 9 | Alzheimers disease_Homo sapiens_hsa05010 | 2.19756959 |
| 10 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.17874463 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.13595779 |
| 12 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.12139897 |
| 13 | DNA replication_Homo sapiens_hsa03030 | 2.06821743 |
| 14 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.96797727 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.96010462 |
| 16 | Mismatch repair_Homo sapiens_hsa03430 | 1.90988928 |
| 17 | Allograft rejection_Homo sapiens_hsa05330 | 1.77514753 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.73026326 |
| 19 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.59875428 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.57525318 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.56939098 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.52384043 |
| 23 | Sulfur relay system_Homo sapiens_hsa04122 | 1.50927024 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.44040342 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.39486937 |
| 26 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.38404963 |
| 27 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.35149290 |
| 28 | Spliceosome_Homo sapiens_hsa03040 | 1.34053190 |
| 29 | Basal transcription factors_Homo sapiens_hsa03022 | 1.31199825 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28011428 |
| 31 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.19517176 |
| 32 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.18866690 |
| 33 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.18526290 |
| 34 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.12835975 |
| 35 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.11158954 |
| 36 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.09438909 |
| 37 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.08596569 |
| 38 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.06709509 |
| 39 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.05706564 |
| 40 | RNA degradation_Homo sapiens_hsa03018 | 1.05561849 |
| 41 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.05485027 |
| 42 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.04493721 |
| 43 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.03152701 |
| 44 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.01485410 |
| 45 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.00985790 |
| 46 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.96565500 |
| 47 | RNA transport_Homo sapiens_hsa03013 | 0.95531009 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.93923356 |
| 49 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.92727346 |
| 50 | Purine metabolism_Homo sapiens_hsa00230 | 0.91708118 |
| 51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.88831445 |
| 52 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.87625870 |
| 53 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.87181394 |
| 54 | Retinol metabolism_Homo sapiens_hsa00830 | 0.84458967 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.81953299 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.79628657 |
| 57 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.79016342 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.76509766 |
| 59 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.75750988 |
| 60 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.73714395 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72068708 |
| 62 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.70693626 |
| 63 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.69042214 |
| 64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.66172912 |
| 65 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.64347498 |
| 66 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.63691301 |
| 67 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.63570651 |
| 68 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.62093185 |
| 69 | Peroxisome_Homo sapiens_hsa04146 | 0.61871537 |
| 70 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.61780266 |
| 71 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.58102929 |
| 72 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.56780610 |
| 73 | Viral myocarditis_Homo sapiens_hsa05416 | 0.56269783 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.56127947 |
| 75 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51977502 |
| 76 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.51613103 |
| 77 | Leishmaniasis_Homo sapiens_hsa05140 | 0.50709313 |
| 78 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46434537 |
| 79 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.45522727 |
| 80 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.44984561 |
| 81 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.43985308 |
| 82 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.42597105 |
| 83 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.41116529 |
| 84 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.41069666 |
| 85 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40773772 |
| 86 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39616188 |
| 87 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.39083530 |
| 88 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.34811296 |
| 89 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.34556719 |
| 90 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.32630073 |
| 91 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.31848394 |
| 92 | Histidine metabolism_Homo sapiens_hsa00340 | 0.29424833 |
| 93 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.28804615 |
| 94 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.26284246 |
| 95 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.25911322 |
| 96 | Cell cycle_Homo sapiens_hsa04110 | 0.25053629 |
| 97 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.22729433 |
| 98 | Mineral absorption_Homo sapiens_hsa04978 | 0.19921486 |
| 99 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.18968938 |
| 100 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.16211604 |

