DDX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1enteric nervous system development (GO:0048484)8.41028566
2sympathetic nervous system development (GO:0048485)6.19171840
3negative regulation of dendrite morphogenesis (GO:0050774)5.81024320
4ganglion development (GO:0061548)5.63286971
5DNA unwinding involved in DNA replication (GO:0006268)5.50501215
6negative regulation of mRNA metabolic process (GO:1903312)5.18629810
7nuclear pore organization (GO:0006999)4.60254950
8positive regulation of cell cycle checkpoint (GO:1901978)4.59044428
9positive regulation of transcription regulatory region DNA binding (GO:2000679)4.48756923
10cell migration in hindbrain (GO:0021535)4.45910833
11DNA replication-dependent nucleosome organization (GO:0034723)4.43687197
12DNA replication-dependent nucleosome assembly (GO:0006335)4.43687197
13DNA replication initiation (GO:0006270)4.32206439
14regulation of secondary heart field cardioblast proliferation (GO:0003266)4.31885683
15regulation of cardioblast proliferation (GO:0003264)4.31885683
16IMP biosynthetic process (GO:0006188)4.27846368
17DNA strand elongation involved in DNA replication (GO:0006271)4.27133417
18dopaminergic neuron differentiation (GO:0071542)4.26719816
19positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)4.22395141
20positive regulation of cell cycle G2/M phase transition (GO:1902751)4.22395141
21nucleobase biosynthetic process (GO:0046112)4.22289759
22negative regulation of protein autophosphorylation (GO:0031953)4.20127681
23nuclear pore complex assembly (GO:0051292)4.16548694
24purine nucleobase biosynthetic process (GO:0009113)4.00224717
25DNA strand elongation (GO:0022616)3.99753095
26cullin deneddylation (GO:0010388)3.93832460
27folic acid-containing compound biosynthetic process (GO:0009396)3.92318377
28IMP metabolic process (GO:0046040)3.85988531
29chaperone-mediated protein complex assembly (GO:0051131)3.79757712
30establishment of integrated proviral latency (GO:0075713)3.76944698
31behavioral response to nicotine (GO:0035095)3.63250236
32regulation of mRNA catabolic process (GO:0061013)3.59311755
33formation of translation preinitiation complex (GO:0001731)3.58320989
34non-recombinational repair (GO:0000726)3.56389998
35double-strand break repair via nonhomologous end joining (GO:0006303)3.56389998
36telomere maintenance via semi-conservative replication (GO:0032201)3.52047591
37protein localization to kinetochore (GO:0034501)3.52032957
38mitotic sister chromatid segregation (GO:0000070)3.49544671
39postreplication repair (GO:0006301)3.48434135
40sister chromatid segregation (GO:0000819)3.48181524
41regulation of centriole replication (GO:0046599)3.48046647
42DNA replication checkpoint (GO:0000076)3.47248097
43mitotic nuclear envelope disassembly (GO:0007077)3.46071751
44protein deneddylation (GO:0000338)3.45929152
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44580240
46chromatin remodeling at centromere (GO:0031055)3.41454011
47mitotic metaphase plate congression (GO:0007080)3.37005947
48regulation of centrosome cycle (GO:0046605)3.36596561
49kinetochore organization (GO:0051383)3.35959110
50ribosome assembly (GO:0042255)3.35648448
51CENP-A containing nucleosome assembly (GO:0034080)3.30832460
52regulation of translational termination (GO:0006449)3.30733748
53mitotic recombination (GO:0006312)3.28967643
54membrane disassembly (GO:0030397)3.28596679
55nuclear envelope disassembly (GO:0051081)3.28596679
56tRNA aminoacylation for protein translation (GO:0006418)3.27261245
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26807226
58histone exchange (GO:0043486)3.23123478
59amino acid activation (GO:0043038)3.22660798
60tRNA aminoacylation (GO:0043039)3.22660798
61mitotic chromosome condensation (GO:0007076)3.21943461
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20342319
63negative regulation of sister chromatid segregation (GO:0033046)3.20342319
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.20342319
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20342319
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20163640
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.19075333
68telomere maintenance via recombination (GO:0000722)3.18490413
69peptidyl-arginine omega-N-methylation (GO:0035247)3.18026093
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16449087
71negative regulation of chromosome segregation (GO:0051985)3.16221808
72pore complex assembly (GO:0046931)3.15028295
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14237344
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.14237344
75coronary vasculature morphogenesis (GO:0060977)3.12885712
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12312187
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11924869
78spindle assembly checkpoint (GO:0071173)3.11576954
79mitotic spindle assembly checkpoint (GO:0007094)3.11562960
80regulation of translational fidelity (GO:0006450)3.08984869
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08103624
82regulation of chromosome segregation (GO:0051983)3.07215534
83spliceosomal snRNP assembly (GO:0000387)3.05997221
84mitotic spindle checkpoint (GO:0071174)3.05918588
85negative regulation of dendrite development (GO:2000171)3.05378401
86regulation of heart morphogenesis (GO:2000826)3.03105954
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02560096
88regulation of mitotic spindle checkpoint (GO:1903504)3.02250251
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02250251
90spindle checkpoint (GO:0031577)3.01343076
91DNA topological change (GO:0006265)3.00815350
92* DNA geometric change (GO:0032392)3.00795023
93* DNA duplex unwinding (GO:0032508)3.00501912
94DNA replication-independent nucleosome organization (GO:0034724)3.00460963
95DNA replication-independent nucleosome assembly (GO:0006336)3.00460963
96kinetochore assembly (GO:0051382)2.99995322
97negative regulation of ligase activity (GO:0051352)2.98893072
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98893072
99metaphase plate congression (GO:0051310)2.98684525
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97080587
101attachment of spindle microtubules to kinetochore (GO:0008608)2.95726430
102regulation of centrosome duplication (GO:0010824)2.92335810
103histone arginine methylation (GO:0034969)2.92321087
104nucleobase-containing small molecule interconversion (GO:0015949)2.91876618
105regulation of respiratory gaseous exchange (GO:0043576)2.89316741
106positive regulation of chromosome segregation (GO:0051984)2.88887935
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88152090
108regulation of sister chromatid segregation (GO:0033045)2.87754876
109regulation of mitotic sister chromatid separation (GO:0010965)2.87754876
110regulation of mitotic sister chromatid segregation (GO:0033047)2.87754876
111pre-miRNA processing (GO:0031054)2.86692929
112ribosome biogenesis (GO:0042254)2.86519741
113de novo protein folding (GO:0006458)2.86379060
114translesion synthesis (GO:0019985)2.84791969
115G1/S transition of mitotic cell cycle (GO:0000082)2.84208664
116cell cycle G1/S phase transition (GO:0044843)2.84208664
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83137132
118replication fork processing (GO:0031297)2.82411743
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81311264
120regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.81244955
121mitotic sister chromatid cohesion (GO:0007064)2.81152870
122deoxyribonucleotide biosynthetic process (GO:0009263)2.79844205
123regulation of mitotic spindle organization (GO:0060236)2.78640556
124viral mRNA export from host cell nucleus (GO:0046784)2.77774155
125telomere maintenance via telomere lengthening (GO:0010833)2.77529915
126protein localization to chromosome, centromeric region (GO:0071459)2.77466072
127establishment of chromosome localization (GO:0051303)2.77219038
128peptidyl-arginine N-methylation (GO:0035246)2.76103183
129peptidyl-arginine methylation (GO:0018216)2.76103183
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.75736381
131mitotic cell cycle (GO:0000278)2.75618548
132protein complex localization (GO:0031503)2.73375666
133regulation of spindle organization (GO:0090224)2.73202246
134negative regulation of cell cycle arrest (GO:0071157)2.72163360
135microtubule depolymerization (GO:0007019)2.70952042
136ATP-dependent chromatin remodeling (GO:0043044)2.70832396
137termination of RNA polymerase II transcription (GO:0006369)2.70452494
138histone H2A acetylation (GO:0043968)2.70197431
139cellular protein complex localization (GO:0034629)2.70015669
140DNA ligation (GO:0006266)2.68134316
141negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.67501689
142regulation of cell cycle G2/M phase transition (GO:1902749)2.67178076
143regulation of sister chromatid cohesion (GO:0007063)2.65675829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.78633142
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.59039627
3GATA1_22025678_ChIP-Seq_K562_Human4.48699183
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.22567277
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81390654
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.64515683
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59219761
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.38195431
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32909373
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.10137047
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09048839
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89595153
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.89175073
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83649103
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82484373
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.79372016
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.79304308
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78753489
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70412918
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67299139
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66426535
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.62842712
23AR_21909140_ChIP-Seq_LNCAP_Human2.55783172
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54081807
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38301538
26XRN2_22483619_ChIP-Seq_HELA_Human2.33324926
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22995545
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18769108
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.17369043
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13540798
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03957553
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03508779
33DCP1A_22483619_ChIP-Seq_HELA_Human2.01851154
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00422372
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.99037072
36* VDR_23849224_ChIP-Seq_CD4+_Human1.97729135
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95914070
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.94311168
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.88692565
40ELK1_19687146_ChIP-ChIP_HELA_Human1.86679949
41* GABP_19822575_ChIP-Seq_HepG2_Human1.84653668
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82914067
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82094633
44FOXP3_21729870_ChIP-Seq_TREG_Human1.80350172
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78292428
46TTF2_22483619_ChIP-Seq_HELA_Human1.72697337
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72027867
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66032999
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61449245
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58525179
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47521056
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44045579
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41168014
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39758348
55* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39347701
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37838299
57KDM5A_27292631_Chip-Seq_BREAST_Human1.37722166
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.36737407
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.34091686
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30320416
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28455730
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28383526
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27620754
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27521752
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22621690
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19536367
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.17737906
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16203697
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15660420
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13940567
71CIITA_25753668_ChIP-Seq_RAJI_Human1.12530460
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11157292
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.08623466
74* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07110291
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.07072508
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06686493
77TFEB_21752829_ChIP-Seq_HELA_Human1.05157718
78* ETV1_20927104_ChIP-Seq_GIST48_Human1.05031065
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.04532504
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04382992
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04355847
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04130496
83* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03274734
84* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02779231
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02660221
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00709404
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98742042
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96142364
89SOX9_26525672_Chip-Seq_HEART_Mouse0.95841003
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94919870
91* MYC_18940864_ChIP-ChIP_HL60_Human0.94289030
92FUS_26573619_Chip-Seq_HEK293_Human0.93444409
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92640227
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92517559
95RBPJ_21746931_ChIP-Seq_IB4_Human0.92491137
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91396706
97* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88323806
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.87670449
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.87399506
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87082317
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85962321
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85920436
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85481676
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.83487428
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83461637
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81889891
107GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80005805
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77635662
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76308902
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75688055
111POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75243973
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75197070
113EWS_26573619_Chip-Seq_HEK293_Human0.74730183
114CHD1_26751641_Chip-Seq_LNCaP_Human0.70895382
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.70595373
116* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69942875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.99478207
2MP0010094_abnormal_chromosome_stability3.79191477
3MP0004957_abnormal_blastocyst_morpholog3.53315427
4MP0008961_abnormal_basal_metabolism3.19437725
5MP0008877_abnormal_DNA_methylation3.17196767
6MP0003111_abnormal_nucleus_morphology3.03211479
7MP0008057_abnormal_DNA_replication2.97016616
8MP0003123_paternal_imprinting2.96359713
9MP0003077_abnormal_cell_cycle2.93459029
10MP0003693_abnormal_embryo_hatching2.85401681
11MP0008932_abnormal_embryonic_tissue2.72001056
12MP0008058_abnormal_DNA_repair2.57634250
13MP0001730_embryonic_growth_arrest2.37107291
14MP0002822_catalepsy2.26192014
15MP0010386_abnormal_urinary_bladder2.20798548
16MP0008007_abnormal_cellular_replicative2.18730484
17MP0000427_abnormal_hair_cycle2.11990915
18MP0003806_abnormal_nucleotide_metabolis2.06991332
19MP0010030_abnormal_orbit_morphology2.04272436
20MP0006276_abnormal_autonomic_nervous1.91817901
21MP0003121_genomic_imprinting1.86787169
22MP0001529_abnormal_vocalization1.84995499
23MP0003890_abnormal_embryonic-extraembry1.84198608
24MP0004233_abnormal_muscle_weight1.78929482
25MP0000537_abnormal_urethra_morphology1.75564040
26MP0010307_abnormal_tumor_latency1.73640904
27MP0010352_gastrointestinal_tract_polyps1.72819839
28MP0005187_abnormal_penis_morphology1.71069017
29MP0000350_abnormal_cell_proliferation1.71007201
30MP0005623_abnormal_meninges_morphology1.68797443
31MP0001697_abnormal_embryo_size1.65520934
32MP0002653_abnormal_ependyma_morphology1.63101233
33MP0001270_distended_abdomen1.55356112
34MP0002084_abnormal_developmental_patter1.54093472
35MP0004197_abnormal_fetal_growth/weight/1.53954997
36MP0002127_abnormal_cardiovascular_syste1.50794064
37MP0002085_abnormal_embryonic_tissue1.49744123
38MP0001672_abnormal_embryogenesis/_devel1.46410392
39MP0005380_embryogenesis_phenotype1.46410392
40MP0005410_abnormal_fertilization1.45146709
41MP0002080_prenatal_lethality1.44092546
42MP0001661_extended_life_span1.40869324
43MP0003122_maternal_imprinting1.40363741
44MP0002210_abnormal_sex_determination1.38443519
45MP0005197_abnormal_uvea_morphology1.34705514
46MP0006072_abnormal_retinal_apoptosis1.32169470
47MP0003984_embryonic_growth_retardation1.31187134
48MP0006054_spinal_hemorrhage1.29620062
49MP0001929_abnormal_gametogenesis1.29284868
50MP0001145_abnormal_male_reproductive1.28378303
51MP0002088_abnormal_embryonic_growth/wei1.26758061
52MP0002009_preneoplasia1.25569305
53MP0002184_abnormal_innervation1.23166935
54MP0003119_abnormal_digestive_system1.22520809
55MP0003698_abnormal_male_reproductive1.21464022
56MP0006292_abnormal_olfactory_placode1.21147410
57MP0006138_congestive_heart_failure1.21001423
58MP0003937_abnormal_limbs/digits/tail_de1.20761623
59MP0004133_heterotaxia1.18523157
60MP0001293_anophthalmia1.17202311
61MP0009672_abnormal_birth_weight1.16958790
62MP0003935_abnormal_craniofacial_develop1.16439280
63MP0000049_abnormal_middle_ear1.13350871
64MP0002160_abnormal_reproductive_system1.11402762
65MP0005083_abnormal_biliary_tract1.08823449
66MP0002269_muscular_atrophy1.06910597
67MP0004134_abnormal_chest_morphology1.06908398
68MP0003786_premature_aging1.06711951
69MP0000653_abnormal_sex_gland1.05464977
70MP0008789_abnormal_olfactory_epithelium1.05445895
71MP0003861_abnormal_nervous_system1.05156656
72MP0003221_abnormal_cardiomyocyte_apopto1.04190263
73MP0001299_abnormal_eye_distance/1.03238334
74MP0009703_decreased_birth_body1.02050264
75MP0000358_abnormal_cell_content/1.01697411
76MP0009697_abnormal_copulation1.01587559
77MP0003943_abnormal_hepatobiliary_system0.97303811
78MP0000747_muscle_weakness0.96672620
79MP0003283_abnormal_digestive_organ0.95961910
80MP0005171_absent_coat_pigmentation0.94683221
81MP0002163_abnormal_gland_morphology0.92880972
82MP0004270_analgesia0.92561121
83MP0002086_abnormal_extraembryonic_tissu0.91248808
84MP0005253_abnormal_eye_physiology0.90714968
85MP0003950_abnormal_plasma_membrane0.90565389
86MP0000428_abnormal_craniofacial_morphol0.90553783
87MP0003942_abnormal_urinary_system0.90156065
88MP0002102_abnormal_ear_morphology0.90143043
89MP0002111_abnormal_tail_morphology0.89942835
90MP0003718_maternal_effect0.89587099
91MP0002234_abnormal_pharynx_morphology0.88979239
92MP0005499_abnormal_olfactory_system0.88278001
93MP0005394_taste/olfaction_phenotype0.88278001
94MP0005551_abnormal_eye_electrophysiolog0.87350552
95MP0003136_yellow_coat_color0.86867255
96MP0000477_abnormal_intestine_morphology0.86083613
97MP0000955_abnormal_spinal_cord0.86024676
98MP0003705_abnormal_hypodermis_morpholog0.85807574
99MP0003567_abnormal_fetal_cardiomyocyte0.84988472
100MP0009053_abnormal_anal_canal0.84893893
101MP0008438_abnormal_cutaneous_collagen0.84397909
102MP0005076_abnormal_cell_differentiation0.84210857
103MP0006035_abnormal_mitochondrial_morpho0.83763261
104MP0000313_abnormal_cell_death0.83395071
105MP0002751_abnormal_autonomic_nervous0.83205073
106MP0004145_abnormal_muscle_electrophysio0.82334509
107MP0006036_abnormal_mitochondrial_physio0.82309587
108MP0000751_myopathy0.81778941
109MP0000534_abnormal_ureter_morphology0.81432784
110MP0000470_abnormal_stomach_morphology0.80060312
111MP0001340_abnormal_eyelid_morphology0.79986071
112MP0000778_abnormal_nervous_system0.79868707
113MP0002161_abnormal_fertility/fecundity0.79546112
114MP0005266_abnormal_metabolism0.78748341
115MP0003755_abnormal_palate_morphology0.78561956
116MP0004147_increased_porphyrin_level0.78367824
117MP0002092_abnormal_eye_morphology0.78195039
118MP0001664_abnormal_digestion0.77752051
119MP0004084_abnormal_cardiac_muscle0.77519946
120MP0000647_abnormal_sebaceous_gland0.76284383
121MP0003632_abnormal_nervous_system0.75756595
122MP0008770_decreased_survivor_rate0.73772602
123MP0000538_abnormal_urinary_bladder0.73614655
124MP0005391_vision/eye_phenotype0.72808785
125MP0004811_abnormal_neuron_physiology0.71521940
126MP0005645_abnormal_hypothalamus_physiol0.71282500
127MP0002152_abnormal_brain_morphology0.70717485
128MP0002882_abnormal_neuron_morphology0.70621248
129MP0003115_abnormal_respiratory_system0.70437320
130MP0000749_muscle_degeneration0.70039476
131MP0001727_abnormal_embryo_implantation0.69935804
132MP0002081_perinatal_lethality0.69864735
133MP0002697_abnormal_eye_size0.68769352
134MP0000631_abnormal_neuroendocrine_gland0.68522570
135MP0001485_abnormal_pinna_reflex0.68397478
136MP0002114_abnormal_axial_skeleton0.67798995
137MP0005384_cellular_phenotype0.67150395
138MP0004185_abnormal_adipocyte_glucose0.67020301
139MP0001286_abnormal_eye_development0.65000766

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)9.70563489
2Intestinal atresia (HP:0011100)5.52312718
3Abnormality of glycolysis (HP:0004366)4.48986640
4Increased serum pyruvate (HP:0003542)4.48986640
5Abnormality of the phalanges of the 2nd finger (HP:0009541)4.21030899
6Secondary amenorrhea (HP:0000869)3.95384110
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84978958
8Ependymoma (HP:0002888)3.71777094
9Cerebral hypomyelination (HP:0006808)3.67099945
10Chromsome breakage (HP:0040012)3.62223834
11Birth length less than 3rd percentile (HP:0003561)3.51566206
12Gastrointestinal atresia (HP:0002589)3.50922279
13Abnormality of the labia minora (HP:0012880)3.46270535
14Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.42160312
15Central scotoma (HP:0000603)3.39123124
16Annular pancreas (HP:0001734)3.33526677
17Depressed nasal tip (HP:0000437)3.32959476
18Tubulointerstitial fibrosis (HP:0005576)3.31200370
19Degeneration of anterior horn cells (HP:0002398)3.19594508
20Abnormality of the anterior horn cell (HP:0006802)3.19594508
21Hypoproteinemia (HP:0003075)3.17769620
22Hypoplastic nipples (HP:0002557)3.14263448
23Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.10022632
24Subcapsular cataract (HP:0000523)3.09737242
25Astrocytoma (HP:0009592)3.06234720
26Abnormality of the astrocytes (HP:0100707)3.06234720
27Neuroblastic tumors (HP:0004376)3.01016147
28Peripheral primitive neuroectodermal neoplasm (HP:0030067)3.01016147
29Neuroblastoma (HP:0003006)3.01016147
30Primitive neuroectodermal tumor (HP:0030065)3.01016147
31Scotoma (HP:0000575)2.96171281
32Shoulder girdle muscle weakness (HP:0003547)2.95895024
33Colon cancer (HP:0003003)2.94614869
34Selective tooth agenesis (HP:0001592)2.92744384
35Medulloblastoma (HP:0002885)2.88581679
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.75936059
37Tubulointerstitial abnormality (HP:0001969)2.74662893
38Sandal gap (HP:0001852)2.72058794
39Abnormality of the vocal cords (HP:0008777)2.69564753
40Palpebral edema (HP:0100540)2.68203028
41Glioma (HP:0009733)2.67769463
42Asplenia (HP:0001746)2.60564220
43Abnormality of the 2nd finger (HP:0004100)2.56796524
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.53951291
45Abnormality of the phalanges of the 5th finger (HP:0004213)2.53119780
46Increased corneal curvature (HP:0100692)2.51709398
47Keratoconus (HP:0000563)2.51709398
48Agnosia (HP:0010524)2.48867291
49Rhabdomyosarcoma (HP:0002859)2.44324813
50Hypotrichosis (HP:0001006)2.38592666
51Postnatal microcephaly (HP:0005484)2.35942439
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.34902596
53CNS hypomyelination (HP:0003429)2.34714528
54Aplasia/Hypoplasia of the nipples (HP:0006709)2.33493537
55Exotropia (HP:0000577)2.31239724
56Short palpebral fissure (HP:0012745)2.29690152
57Amblyopia (HP:0000646)2.29122214
58Increased nuchal translucency (HP:0010880)2.28271907
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.27345039
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.23732523
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.23010319
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23010319
63Facial asymmetry (HP:0000324)2.22546926
64Pelvic girdle muscle weakness (HP:0003749)2.21564085
65Insidious onset (HP:0003587)2.19606191
66Termporal pattern (HP:0011008)2.19606191
67Abnormality of the hip-girdle musculature (HP:0001445)2.17218851
68Abnormality of the musculature of the pelvis (HP:0001469)2.17218851
69Hypoventilation (HP:0002791)2.10684266
70Abnormal lung lobation (HP:0002101)2.10099952
71Abnormality of the lower motor neuron (HP:0002366)2.09923275
72Cortical dysplasia (HP:0002539)2.09614478
73Abnormal mitochondria in muscle tissue (HP:0008316)2.09404784
74Ovarian neoplasm (HP:0100615)2.09061284
75Choanal atresia (HP:0000453)2.07386153
76Proximal placement of thumb (HP:0009623)2.06933154
77Acute necrotizing encephalopathy (HP:0006965)2.06308210
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06021172
79Absent epiphyses (HP:0010577)2.06021172
80Decreased skull ossification (HP:0004331)2.03410326
81Malignant neoplasm of the central nervous system (HP:0100836)2.01363612
82Rimmed vacuoles (HP:0003805)2.00125388
83Abnormality of the preputium (HP:0100587)1.99529684
84Deviation of the thumb (HP:0009603)1.99520537
85Angiofibromas (HP:0010615)1.98536172
86Adenoma sebaceum (HP:0009720)1.98536172
87Pheochromocytoma (HP:0002666)1.98053805
88Missing ribs (HP:0000921)1.97585334
89Neuroepithelial neoplasm (HP:0030063)1.95063241
90Nervous tissue neoplasm (HP:0030060)1.95063241
91Neuroectodermal neoplasm (HP:0030061)1.95063241
92Volvulus (HP:0002580)1.93962694
93Neuroendocrine neoplasm (HP:0100634)1.92206543
94Freckling (HP:0001480)1.89321546
95Leukodystrophy (HP:0002415)1.88791490
96Overlapping toe (HP:0001845)1.88120125
97Facial cleft (HP:0002006)1.87754849
98Resting tremor (HP:0002322)1.87609741
99Patellar aplasia (HP:0006443)1.86295546
100Breast hypoplasia (HP:0003187)1.86263679
101Delayed cranial suture closure (HP:0000270)1.84912828
102Neoplasm of striated muscle (HP:0009728)1.84356831
103Limb-girdle muscle weakness (HP:0003325)1.84142872
104Abnormality of the carotid arteries (HP:0005344)1.82599465
105Shawl scrotum (HP:0000049)1.81972532
106Irregular epiphyses (HP:0010582)1.81646790
107Oral leukoplakia (HP:0002745)1.79956230
108Absent radius (HP:0003974)1.79893730
109Supernumerary spleens (HP:0009799)1.79358711
110Abnormality of dentin (HP:0010299)1.79314499
111Abnormality of chromosome stability (HP:0003220)1.79281834
112Aplasia/Hypoplasia of the breasts (HP:0010311)1.79120414
113Sloping forehead (HP:0000340)1.78460042
114Embryonal renal neoplasm (HP:0011794)1.78304892
115Neoplasm of the colon (HP:0100273)1.78219230
116Protruding ear (HP:0000411)1.77691404
117Carpal bone hypoplasia (HP:0001498)1.77559782
118Neoplasm of the rectum (HP:0100743)1.77040963
119Abnormality of the calcaneus (HP:0008364)1.76542670
120Aplasia/Hypoplasia of the patella (HP:0006498)1.76318794
121Microvesicular hepatic steatosis (HP:0001414)1.75254586
122Duodenal stenosis (HP:0100867)1.75163445
123Small intestinal stenosis (HP:0012848)1.75163445
124Biliary tract neoplasm (HP:0100574)1.74880477
125Abnormal number of incisors (HP:0011064)1.74721809
126Neoplasm of the pancreas (HP:0002894)1.74674197
127External ophthalmoplegia (HP:0000544)1.73929576
128Neoplasm of the peripheral nervous system (HP:0100007)1.73486989
129Constricted visual fields (HP:0001133)1.72986583
130Nephroblastoma (Wilms tumor) (HP:0002667)1.72636247
131Intestinal polyposis (HP:0200008)1.70065225
132Increased CSF lactate (HP:0002490)1.69169694
133Atresia of the external auditory canal (HP:0000413)1.66252609
134Postnatal growth retardation (HP:0008897)1.64441593
135Meckel diverticulum (HP:0002245)1.64050493
136Neoplasm of the oral cavity (HP:0100649)1.63975996
137Poor suck (HP:0002033)1.63337323
138Absent forearm bone (HP:0003953)1.63145512
139Aplasia involving forearm bones (HP:0009822)1.63145512
140Urinary urgency (HP:0000012)1.63056845
141Abnormality of abdominal situs (HP:0011620)1.62987504
142Abdominal situs inversus (HP:0003363)1.62987504
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62600518
144Abnormality of alanine metabolism (HP:0010916)1.62600518
145Hyperalaninemia (HP:0003348)1.62600518
146Sex reversal (HP:0012245)1.62345737
147Abnormal sex determination (HP:0012244)1.62345737
148Congenital malformation of the right heart (HP:0011723)1.62296716
149Double outlet right ventricle (HP:0001719)1.62296716
150Intestinal polyp (HP:0005266)1.61755620
151Acute encephalopathy (HP:0006846)1.61113252
152Abnormality of the septum pellucidum (HP:0007375)1.61052977
153Abnormality of cochlea (HP:0000375)1.60142919
154Broad distal phalanx of finger (HP:0009836)1.60128860
155Septo-optic dysplasia (HP:0100842)1.59979603
156Esophageal atresia (HP:0002032)1.59391129
157Emotional lability (HP:0000712)1.58914603
158Type 2 muscle fiber atrophy (HP:0003554)1.58463294
159Abnormality of the pons (HP:0007361)1.58025133
160Exercise-induced muscle cramps (HP:0003710)1.57748425
161Hypoplastic pelvis (HP:0008839)1.57727654
162Abnormality of skull ossification (HP:0002703)1.57268614
163Progressive macrocephaly (HP:0004481)1.57103632
164Abnormality of the ileum (HP:0001549)1.56675877
165Cafe-au-lait spot (HP:0000957)1.56599371
166Posterior subcapsular cataract (HP:0007787)1.56560744
167Triphalangeal thumb (HP:0001199)1.56066323
168Abnormality of the duodenum (HP:0002246)1.55895636
169Wide anterior fontanel (HP:0000260)1.54054540
170Abnormality of the corticospinal tract (HP:0002492)1.53890816
171Generalized hypotonia (HP:0001290)1.52495386
172Abnormality of the phalanges of the hallux (HP:0010057)1.52274516

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.35832500
2BUB14.01596676
3MAP3K103.95923564
4NEK13.41593103
5WEE13.23765342
6TSSK63.19060704
7EIF2AK12.87435143
8PDK42.44826878
9PDK32.44826878
10PASK2.19934099
11ICK2.12724882
12SCYL22.07196922
13PLK32.05304195
14PBK2.04570083
15TTK2.03579522
16SRPK11.93106790
17NME21.88436390
18EIF2AK31.84085120
19PNCK1.81797468
20ACVR1B1.77168625
21BRD41.75780191
22NTRK11.70666086
23MKNK11.69027904
24BRSK21.67130322
25BCR1.66373796
26NEK21.61857196
27LIMK11.60477886
28PLK11.59372430
29CCNB11.58001204
30TESK21.54024182
31PDK21.53780066
32PLK41.53630085
33TESK11.51701148
34PLK21.44943434
35BRSK11.42038393
36ATR1.32254604
37AURKA1.24584158
38CHEK11.16117109
39CLK11.12925301
40CHEK21.10258585
41STK161.10220775
42VRK11.09090259
43AURKB1.08294227
44NME11.04432570
45CDK140.99202326
46INSRR0.95820378
47CDK180.94955028
48MET0.94867662
49RPS6KB20.94720745
50BRAF0.93456258
51CDK150.92489635
52TRIM280.88024912
53MAP3K40.87094157
54PAK40.85751897
55UHMK10.82402337
56CDK11A0.81003210
57FGFR10.80753158
58MTOR0.80553581
59ATM0.80352701
60CSNK1G10.78745377
61STK390.77629038
62FGFR20.77401374
63DYRK30.75641595
64MINK10.74666823
65EPHA20.74542671
66CDK70.74455777
67TGFBR10.74089761
68PAK10.73201897
69CASK0.73128266
70MAP4K20.72689890
71CDK20.72296272
72PDGFRA0.71899851
73CDK10.70953568
74CDK190.70773484
75CDK60.69296921
76CSNK2A20.68078304
77MAP3K80.67941571
78MKNK20.64323577
79OXSR10.63041145
80CSNK1E0.62179765
81KSR10.60718650
82MST40.58894152
83ERBB30.58138281
84TLK10.57896038
85AKT20.57762136
86ZAK0.57315148
87DAPK10.57210870
88PRKD30.56711234
89MELK0.55828944
90ALK0.55530437
91TTN0.53543883
92CSNK1G30.53185068
93CSNK2A10.52038570
94CDK80.50928754
95STK40.49056411
96PRKDC0.49047513
97PRKCI0.47463347
98ARAF0.46468894
99FGFR40.44765187
100FLT30.44433941
101DYRK20.43516473
102EIF2AK20.43042024
103PAK60.42484990
104TAF10.42329744
105CSNK1D0.41517302
106CDK40.41022205
107PKN20.38792181
108MAPK140.38787537
109SIK30.38655897
110ROCK20.38401048
111EEF2K0.37933298
112MAPK110.37700323
113CDK30.36279191
114WNK30.36218573
115RPS6KB10.35023277
116CSNK1G20.34949496
117FER0.34875435
118ERBB40.33801779
119LATS20.33279521
120CDK120.32908915
121VRK20.32220370
122ILK0.31900023
123PRKCG0.31534345
124GSK3B0.31364853
125NTRK20.30298479
126MATK0.29994445
127CSNK1A1L0.29782054
128ADRBK20.29343399
129PAK20.29249238
130CAMK2B0.29005297
131DYRK1B0.27927787
132MARK10.27891655
133MAP2K70.27482520
134PRKACB0.24899288

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30116178
2Mismatch repair_Homo sapiens_hsa034303.98141029
3Proteasome_Homo sapiens_hsa030503.72914111
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.42400150
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35073513
6RNA transport_Homo sapiens_hsa030133.04840805
7Spliceosome_Homo sapiens_hsa030403.04234293
8Cell cycle_Homo sapiens_hsa041102.60868214
9Nucleotide excision repair_Homo sapiens_hsa034202.59560344
10One carbon pool by folate_Homo sapiens_hsa006702.53444168
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42277090
12RNA polymerase_Homo sapiens_hsa030202.29900264
13Homologous recombination_Homo sapiens_hsa034402.21388610
14Base excision repair_Homo sapiens_hsa034102.14719596
15Basal transcription factors_Homo sapiens_hsa030221.87113296
16Non-homologous end-joining_Homo sapiens_hsa034501.79204555
17mRNA surveillance pathway_Homo sapiens_hsa030151.78218857
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72323554
19Pyrimidine metabolism_Homo sapiens_hsa002401.68865910
20RNA degradation_Homo sapiens_hsa030181.66588241
21Fanconi anemia pathway_Homo sapiens_hsa034601.62938862
22Biosynthesis of amino acids_Homo sapiens_hsa012301.62881311
23Oocyte meiosis_Homo sapiens_hsa041141.61486067
24Pyruvate metabolism_Homo sapiens_hsa006201.47349003
25Protein export_Homo sapiens_hsa030601.45237911
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44728390
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42578026
28Parkinsons disease_Homo sapiens_hsa050121.41724348
29Carbon metabolism_Homo sapiens_hsa012001.37591170
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.37245484
31Oxidative phosphorylation_Homo sapiens_hsa001901.34553142
32Huntingtons disease_Homo sapiens_hsa050161.28078838
33Systemic lupus erythematosus_Homo sapiens_hsa053221.27257710
34Ribosome_Homo sapiens_hsa030101.25680252
35Purine metabolism_Homo sapiens_hsa002301.22294689
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17819184
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14130553
38Vibrio cholerae infection_Homo sapiens_hsa051101.06464639
39Alcoholism_Homo sapiens_hsa050341.05224477
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02300488
41Selenocompound metabolism_Homo sapiens_hsa004500.99693509
42Synaptic vesicle cycle_Homo sapiens_hsa047210.92759729
43p53 signaling pathway_Homo sapiens_hsa041150.87411127
44Phototransduction_Homo sapiens_hsa047440.87029943
45Vitamin B6 metabolism_Homo sapiens_hsa007500.86872335
46Viral carcinogenesis_Homo sapiens_hsa052030.86218705
47Lysine degradation_Homo sapiens_hsa003100.85709763
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85156081
49Epstein-Barr virus infection_Homo sapiens_hsa051690.80381842
50Pentose phosphate pathway_Homo sapiens_hsa000300.78917537
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78297055
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77253001
53Arginine biosynthesis_Homo sapiens_hsa002200.73249500
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72917396
55Alzheimers disease_Homo sapiens_hsa050100.69841761
56Collecting duct acid secretion_Homo sapiens_hsa049660.69150854
57Fatty acid metabolism_Homo sapiens_hsa012120.67866980
58N-Glycan biosynthesis_Homo sapiens_hsa005100.66256234
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64526297
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57510740
61Tight junction_Homo sapiens_hsa045300.57016996
62Fructose and mannose metabolism_Homo sapiens_hsa000510.56043175
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55942235
64Hippo signaling pathway_Homo sapiens_hsa043900.54759946
65Glutathione metabolism_Homo sapiens_hsa004800.52876217
66Steroid biosynthesis_Homo sapiens_hsa001000.51194209
67Propanoate metabolism_Homo sapiens_hsa006400.49362113
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49082024
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48558116
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48393042
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.47020478
72Hedgehog signaling pathway_Homo sapiens_hsa043400.43108900
73Cardiac muscle contraction_Homo sapiens_hsa042600.42740024
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41217685
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.39088621
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36581284
77Metabolic pathways_Homo sapiens_hsa011000.35387612
78Arginine and proline metabolism_Homo sapiens_hsa003300.35100212
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34972105
80Cholinergic synapse_Homo sapiens_hsa047250.34583473
81Thyroid cancer_Homo sapiens_hsa052160.34230803
82Folate biosynthesis_Homo sapiens_hsa007900.33395482
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33269885
84Sulfur relay system_Homo sapiens_hsa041220.32770558
85Glioma_Homo sapiens_hsa052140.32681595
86Fatty acid elongation_Homo sapiens_hsa000620.31730331
87Taste transduction_Homo sapiens_hsa047420.31398022
88Inositol phosphate metabolism_Homo sapiens_hsa005620.31298529
89Fatty acid biosynthesis_Homo sapiens_hsa000610.30162191
90Fatty acid degradation_Homo sapiens_hsa000710.29898686
91Dopaminergic synapse_Homo sapiens_hsa047280.29834544
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28867636
93Glucagon signaling pathway_Homo sapiens_hsa049220.27072626
94Non-small cell lung cancer_Homo sapiens_hsa052230.25803610
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25039235
96Colorectal cancer_Homo sapiens_hsa052100.24904469
97Basal cell carcinoma_Homo sapiens_hsa052170.24832602
98HTLV-I infection_Homo sapiens_hsa051660.24273443
99Adherens junction_Homo sapiens_hsa045200.23284695
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23044557
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22952511
102TGF-beta signaling pathway_Homo sapiens_hsa043500.21230569
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20848794
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19074374
105MicroRNAs in cancer_Homo sapiens_hsa052060.18789948
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18320316
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16315412
108Sulfur metabolism_Homo sapiens_hsa009200.15959677
109Wnt signaling pathway_Homo sapiens_hsa043100.15665341
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15465171
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13965367
112Butanoate metabolism_Homo sapiens_hsa006500.13308485
113Nicotine addiction_Homo sapiens_hsa050330.13031470
114Galactose metabolism_Homo sapiens_hsa000520.12331638
115Melanoma_Homo sapiens_hsa052180.12325238
116Amphetamine addiction_Homo sapiens_hsa050310.11839481
117Phagosome_Homo sapiens_hsa041450.11514117
118GABAergic synapse_Homo sapiens_hsa047270.11171553
119HIF-1 signaling pathway_Homo sapiens_hsa040660.10038580
120Bladder cancer_Homo sapiens_hsa052190.09896371
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07401391
122Tyrosine metabolism_Homo sapiens_hsa003500.07393878

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