DDX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.61745024
2nuclear pore complex assembly (GO:0051292)4.58353680
3maturation of SSU-rRNA (GO:0030490)4.45461192
4DNA replication initiation (GO:0006270)4.34452842
5DNA unwinding involved in DNA replication (GO:0006268)4.16428054
6IMP biosynthetic process (GO:0006188)4.15681034
7nucleobase biosynthetic process (GO:0046112)4.10726280
8ribosome biogenesis (GO:0042254)4.02268370
9purine nucleobase biosynthetic process (GO:0009113)3.93204455
10mitotic metaphase plate congression (GO:0007080)3.87173981
11ribosome assembly (GO:0042255)3.86027032
12ribosomal small subunit assembly (GO:0000028)3.85951639
13synapsis (GO:0007129)3.84494882
14DNA strand elongation involved in DNA replication (GO:0006271)3.84277043
15chromatin remodeling at centromere (GO:0031055)3.84134388
16DNA double-strand break processing (GO:0000729)3.83052484
17positive regulation of histone H3-K4 methylation (GO:0051571)3.82666465
18protein localization to kinetochore (GO:0034501)3.82191805
19CENP-A containing nucleosome assembly (GO:0034080)3.79860722
20mitotic nuclear envelope disassembly (GO:0007077)3.79332793
21formation of translation preinitiation complex (GO:0001731)3.75053311
22ribonucleoprotein complex biogenesis (GO:0022613)3.73575291
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.72663977
24regulation of mitotic spindle checkpoint (GO:1903504)3.72663977
25regulation of DNA endoreduplication (GO:0032875)3.72324414
26centriole replication (GO:0007099)3.70079479
27DNA strand elongation (GO:0022616)3.69446742
28replication fork processing (GO:0031297)3.69059452
29regulation of meiosis I (GO:0060631)3.66184759
30pore complex assembly (GO:0046931)3.65936148
31kinetochore organization (GO:0051383)3.64377175
32IMP metabolic process (GO:0046040)3.62243603
33DNA replication checkpoint (GO:0000076)3.61835118
34telomere maintenance via semi-conservative replication (GO:0032201)3.58017670
35DNA replication-independent nucleosome assembly (GO:0006336)3.57598382
36DNA replication-independent nucleosome organization (GO:0034724)3.57598382
37metaphase plate congression (GO:0051310)3.54850859
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.54757966
39ribosomal large subunit biogenesis (GO:0042273)3.52947455
40nuclear envelope disassembly (GO:0051081)3.52946448
41membrane disassembly (GO:0030397)3.52946448
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52022192
43meiotic cell cycle (GO:0051321)3.49934275
44rRNA processing (GO:0006364)3.48011675
45DNA replication-dependent nucleosome organization (GO:0034723)3.41390578
46DNA replication-dependent nucleosome assembly (GO:0006335)3.41390578
47rRNA metabolic process (GO:0016072)3.38935785
48piRNA metabolic process (GO:0034587)3.38459949
49proteasome assembly (GO:0043248)3.35709663
50protein localization to chromosome, centromeric region (GO:0071459)3.35150899
51attachment of spindle microtubules to kinetochore (GO:0008608)3.34351316
52ribosomal small subunit biogenesis (GO:0042274)3.32859092
53telomere maintenance via recombination (GO:0000722)3.32681185
54histone exchange (GO:0043486)3.31121011
55mitotic recombination (GO:0006312)3.28358744
56meiotic chromosome segregation (GO:0045132)3.28174368
57non-recombinational repair (GO:0000726)3.28064471
58double-strand break repair via nonhomologous end joining (GO:0006303)3.28064471
59folic acid-containing compound biosynthetic process (GO:0009396)3.25926407
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25541171
61regulation of helicase activity (GO:0051095)3.24032807
62regulation of histone H3-K9 methylation (GO:0051570)3.22694374
63DNA duplex unwinding (GO:0032508)3.22315343
64DNA geometric change (GO:0032392)3.21403768
65kinetochore assembly (GO:0051382)3.20898620
66maturation of 5.8S rRNA (GO:0000460)3.18527183
67regulation of spindle organization (GO:0090224)3.16535719
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.15363874
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.15363874
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.15363874
71translational termination (GO:0006415)3.13501233
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12789592
73postreplication repair (GO:0006301)3.12217949
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10416373
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.10416373
76viral transcription (GO:0019083)3.10106643
77telomere maintenance via telomere lengthening (GO:0010833)3.08292190
78establishment of integrated proviral latency (GO:0075713)3.06091113
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05497537
80establishment of chromosome localization (GO:0051303)3.04971012
81positive regulation of chromosome segregation (GO:0051984)3.04159866
82translesion synthesis (GO:0019985)3.03897046
83mitotic sister chromatid segregation (GO:0000070)3.03853792
84mitochondrial RNA metabolic process (GO:0000959)3.03692358
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.02682153
86mitotic sister chromatid cohesion (GO:0007064)3.02066667
87mitotic chromosome condensation (GO:0007076)3.01496012
88retinal cone cell development (GO:0046549)3.01477399
89translational initiation (GO:0006413)3.00946470
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99687357
91protein localization to chromosome (GO:0034502)2.99575179
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99241438
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99241438
94isotype switching (GO:0045190)2.99241438
95regulation of spindle checkpoint (GO:0090231)2.99074262
96regulation of DNA methylation (GO:0044030)2.99064148
97resolution of meiotic recombination intermediates (GO:0000712)2.98876869
98termination of RNA polymerase I transcription (GO:0006363)2.95978529
99negative regulation of chromosome segregation (GO:0051985)2.95677823
100DNA catabolic process, exonucleolytic (GO:0000738)2.95659333
101somatic recombination of immunoglobulin gene segments (GO:0016447)2.94692268
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.94606043
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94606043
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94606043
105negative regulation of sister chromatid segregation (GO:0033046)2.94606043
106regulation of mitotic sister chromatid separation (GO:0010965)2.94026577
107protein K6-linked ubiquitination (GO:0085020)2.92564732
108spindle checkpoint (GO:0031577)2.91968745
109recombinational repair (GO:0000725)2.91659464
110spliceosomal snRNP assembly (GO:0000387)2.91592610
111double-strand break repair via homologous recombination (GO:0000724)2.91561161
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91295903
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90988675
114RNA splicing, via transesterification reactions (GO:0000375)2.90967654
115regulation of centrosome cycle (GO:0046605)2.89830623
116sister chromatid cohesion (GO:0007062)2.88700143
117mRNA splicing, via spliceosome (GO:0000398)2.88598764
118RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88598764
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.87922088
120chromatin assembly or disassembly (GO:0006333)2.87697121
121pseudouridine synthesis (GO:0001522)2.87145191
122transcription elongation from RNA polymerase I promoter (GO:0006362)2.86742080
123negative regulation of histone methylation (GO:0031061)2.86332278
124sister chromatid segregation (GO:0000819)2.85908447
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85640373
126DNA deamination (GO:0045006)2.85391462
127spindle assembly checkpoint (GO:0071173)2.85292839
128regulation of centriole replication (GO:0046599)2.85091121
129mitotic spindle checkpoint (GO:0071174)2.84609598
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84443115
131ATP-dependent chromatin remodeling (GO:0043044)2.83794901
132nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83338299
133rRNA modification (GO:0000154)2.83310910
134mitotic spindle assembly checkpoint (GO:0007094)2.83303068
135regulation of chromosome segregation (GO:0051983)2.82312046
136telomere maintenance (GO:0000723)2.81841302
137regulation of sister chromatid segregation (GO:0033045)2.80671321
138regulation of mitotic sister chromatid segregation (GO:0033047)2.80671321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.53466926
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57158827
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97775148
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.66235562
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.08284715
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06912574
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03995880
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00245532
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96777555
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92426826
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.76310734
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60728548
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.56024950
14* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48064676
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.46824503
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45767370
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43426053
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36267882
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35558401
20VDR_23849224_ChIP-Seq_CD4+_Human2.34889348
21ZNF274_21170338_ChIP-Seq_K562_Hela2.25306780
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19872600
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.17043234
24* EGR1_19374776_ChIP-ChIP_THP-1_Human2.15919890
25XRN2_22483619_ChIP-Seq_HELA_Human2.13843255
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08153084
27ELK1_19687146_ChIP-ChIP_HELA_Human2.04222920
28AR_21909140_ChIP-Seq_LNCAP_Human2.02298372
29FOXP3_21729870_ChIP-Seq_TREG_Human2.01186633
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00908808
31EZH2_22144423_ChIP-Seq_EOC_Human2.00539526
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99904191
33EWS_26573619_Chip-Seq_HEK293_Human1.93975939
34VDR_22108803_ChIP-Seq_LS180_Human1.89285384
35DCP1A_22483619_ChIP-Seq_HELA_Human1.87978725
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87397646
37* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84471838
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83573843
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82711142
40TTF2_22483619_ChIP-Seq_HELA_Human1.79975739
41* NOTCH1_21737748_ChIP-Seq_TLL_Human1.78475647
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76115325
43FUS_26573619_Chip-Seq_HEK293_Human1.74767348
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74524596
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73648614
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73169666
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72648469
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70597337
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.67885427
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67660092
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66702059
52GABP_19822575_ChIP-Seq_HepG2_Human1.65697565
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60903553
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58959580
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.57446438
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55824934
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.54269666
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50790965
59KDM5A_27292631_Chip-Seq_BREAST_Human1.50069353
60MYC_22102868_ChIP-Seq_BL_Human1.49855862
61CIITA_25753668_ChIP-Seq_RAJI_Human1.47657042
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47445837
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46147721
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42101573
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41707243
66TAF15_26573619_Chip-Seq_HEK293_Human1.40143745
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39739479
68IGF1R_20145208_ChIP-Seq_DFB_Human1.37401743
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.36561560
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36114183
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33557782
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29519241
73P300_19829295_ChIP-Seq_ESCs_Human1.27988515
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22333862
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22266681
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20136270
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19138068
78IRF1_19129219_ChIP-ChIP_H3396_Human1.18855397
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17810510
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16525046
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16525046
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16525046
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16435647
84GBX2_23144817_ChIP-Seq_PC3_Human1.16166412
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14402576
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.13939424
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11128368
88TFEB_21752829_ChIP-Seq_HELA_Human1.11093050
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10944837
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10503269
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08337708
92MYC_18940864_ChIP-ChIP_HL60_Human1.07808307
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07793465
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07159059
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04783429
96CBP_20019798_ChIP-Seq_JUKART_Human1.03302432
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03302432
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01773711
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01567343
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01242132
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00288516
102* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98717583
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98569871
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97382946
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93706652
106SPI1_23547873_ChIP-Seq_NB4_Human0.93342643
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92822503
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92724141
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92614651
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92232127
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91960879
112TP53_22573176_ChIP-Seq_HFKS_Human0.91025402
113* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90442749
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90255842
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.88287042
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86903983
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86669591
118STAT3_23295773_ChIP-Seq_U87_Human0.85250267
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83379834
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83234838
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83130203
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82835986
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.82572896
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82444195
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.82388668
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81752171
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.81555642
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81076897
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80121333
130TCF4_23295773_ChIP-Seq_U87_Human0.79822804
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79812661
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79470628
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75743497
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75711870
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75399807
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73595445
137MYB_26560356_Chip-Seq_TH1_Human0.72414797
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69926648
139HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69496504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.97166184
2MP0008057_abnormal_DNA_replication4.72801427
3MP0010094_abnormal_chromosome_stability4.63388884
4MP0004957_abnormal_blastocyst_morpholog4.18743696
5MP0003111_abnormal_nucleus_morphology4.11302041
6MP0003077_abnormal_cell_cycle3.78649741
7MP0008058_abnormal_DNA_repair3.75168093
8MP0008877_abnormal_DNA_methylation3.49235743
9MP0003123_paternal_imprinting3.07791524
10MP0008007_abnormal_cellular_replicative2.88123098
11MP0003786_premature_aging2.48065033
12MP0002396_abnormal_hematopoietic_system2.44964474
13MP0008932_abnormal_embryonic_tissue2.43980989
14MP0001730_embryonic_growth_arrest2.17910103
15MP0000350_abnormal_cell_proliferation2.17625846
16MP0000372_irregular_coat_pigmentation2.01683698
17MP0010352_gastrointestinal_tract_polyps2.00069632
18MP0003121_genomic_imprinting1.90335505
19MP0004808_abnormal_hematopoietic_stem1.87082550
20MP0010307_abnormal_tumor_latency1.71941763
21MP0002234_abnormal_pharynx_morphology1.70971950
22MP0003950_abnormal_plasma_membrane1.68663984
23MP0002210_abnormal_sex_determination1.65706294
24MP0008789_abnormal_olfactory_epithelium1.65225722
25MP0001672_abnormal_embryogenesis/_devel1.61086330
26MP0005380_embryogenesis_phenotype1.61086330
27MP0002102_abnormal_ear_morphology1.60889622
28MP0000569_abnormal_digit_pigmentation1.58299612
29MP0001697_abnormal_embryo_size1.53765209
30MP0005395_other_phenotype1.53288036
31MP0008995_early_reproductive_senescence1.51262209
32MP0002938_white_spotting1.50859838
33MP0003984_embryonic_growth_retardation1.48125476
34MP0000490_abnormal_crypts_of1.46830205
35MP0002088_abnormal_embryonic_growth/wei1.44948723
36MP0004197_abnormal_fetal_growth/weight/1.44661592
37MP0003763_abnormal_thymus_physiology1.43648403
38MP0002084_abnormal_developmental_patter1.42658440
39MP0006072_abnormal_retinal_apoptosis1.42320989
40MP0002085_abnormal_embryonic_tissue1.41564787
41MP0000313_abnormal_cell_death1.37239502
42MP0002080_prenatal_lethality1.36963766
43MP0002086_abnormal_extraembryonic_tissu1.35995182
44MP0001145_abnormal_male_reproductive1.33061210
45MP0002019_abnormal_tumor_incidence1.32442266
46MP0009333_abnormal_splenocyte_physiolog1.31552221
47MP0001929_abnormal_gametogenesis1.29544213
48MP0006292_abnormal_olfactory_placode1.24543450
49MP0003718_maternal_effect1.23409867
50MP0000703_abnormal_thymus_morphology1.22892758
51MP0003890_abnormal_embryonic-extraembry1.22491370
52MP0005499_abnormal_olfactory_system1.21952267
53MP0005394_taste/olfaction_phenotype1.21952267
54MP0001545_abnormal_hematopoietic_system1.19525413
55MP0005397_hematopoietic_system_phenotyp1.19525413
56MP0003136_yellow_coat_color1.18251006
57MP0000653_abnormal_sex_gland1.18192644
58MP0003787_abnormal_imprinting1.18164651
59MP0000537_abnormal_urethra_morphology1.17612224
60MP0002398_abnormal_bone_marrow1.16418969
61MP0003941_abnormal_skin_development1.11759693
62MP0005551_abnormal_eye_electrophysiolog1.11420423
63MP0000427_abnormal_hair_cycle1.10925937
64MP0003315_abnormal_perineum_morphology1.10360588
65MP0002233_abnormal_nose_morphology1.09179820
66MP0003806_abnormal_nucleotide_metabolis1.05918951
67MP0001293_anophthalmia1.05069401
68MP0003699_abnormal_female_reproductive1.04747824
69MP0002163_abnormal_gland_morphology1.03321761
70MP0002722_abnormal_immune_system1.02984069
71MP0000689_abnormal_spleen_morphology1.02683470
72MP0006035_abnormal_mitochondrial_morpho0.98957319
73MP0001849_ear_inflammation0.97184226
74MP0005174_abnormal_tail_pigmentation0.94692440
75MP0003567_abnormal_fetal_cardiomyocyte0.94162064
76MP0005410_abnormal_fertilization0.94001133
77MP0005253_abnormal_eye_physiology0.93921955
78MP0000631_abnormal_neuroendocrine_gland0.92986593
79MP0000647_abnormal_sebaceous_gland0.92323322
80MP0000465_gastrointestinal_hemorrhage0.92033416
81MP0002161_abnormal_fertility/fecundity0.91793441
82MP0001119_abnormal_female_reproductive0.90725505
83MP0000358_abnormal_cell_content/0.86833665
84MP0003186_abnormal_redox_activity0.86690074
85MP0002160_abnormal_reproductive_system0.86494630
86MP0000015_abnormal_ear_pigmentation0.85401717
87MP0002751_abnormal_autonomic_nervous0.84422862
88MP0003937_abnormal_limbs/digits/tail_de0.83688588
89MP0002429_abnormal_blood_cell0.81408175
90MP0001324_abnormal_eye_pigmentation0.79782062
91MP0003646_muscle_fatigue0.79454564
92MP0005671_abnormal_response_to0.79050221
93MP0006036_abnormal_mitochondrial_physio0.77801582
94MP0002095_abnormal_skin_pigmentation0.76597063
95MP0009697_abnormal_copulation0.76228731
96MP0004147_increased_porphyrin_level0.76036126
97MP0004215_abnormal_myocardial_fiber0.75961942
98MP0000716_abnormal_immune_system0.75652069
99MP0005408_hypopigmentation0.75434253
100MP0004133_heterotaxia0.75219514
101MP0010030_abnormal_orbit_morphology0.74867536
102MP0005076_abnormal_cell_differentiation0.74265817
103MP0005075_abnormal_melanosome_morpholog0.73498070
104MP0001529_abnormal_vocalization0.72473849
105MP0003195_calcinosis0.72318922
106MP0003119_abnormal_digestive_system0.71474050
107MP0005389_reproductive_system_phenotype0.71101253
108MP0000049_abnormal_middle_ear0.70110148
109MP0005391_vision/eye_phenotype0.69863298
110MP0003698_abnormal_male_reproductive0.69653962
111MP0002111_abnormal_tail_morphology0.69626876
112MP0006054_spinal_hemorrhage0.69355662
113MP0000432_abnormal_head_morphology0.68954284
114MP0009379_abnormal_foot_pigmentation0.68436735
115MP0001800_abnormal_humoral_immune0.68384051
116MP0005384_cellular_phenotype0.67900240
117MP0000858_altered_metastatic_potential0.67132091
118MP0001853_heart_inflammation0.66718617
119MP0001286_abnormal_eye_development0.66456614
120MP0005621_abnormal_cell_physiology0.64641241
121MP0002837_dystrophic_cardiac_calcinosis0.64231683
122MP0006276_abnormal_autonomic_nervous0.64168926
123MP0001915_intracranial_hemorrhage0.63815273
124MP0003755_abnormal_palate_morphology0.63574354
125MP0001984_abnormal_olfaction0.63326570
126MP0005171_absent_coat_pigmentation0.62647429
127MP0009703_decreased_birth_body0.61537078
128MP0002132_abnormal_respiratory_system0.61530744
129MP0008872_abnormal_physiological_respon0.61142943
130MP0002420_abnormal_adaptive_immunity0.61060121
131MP0003448_altered_tumor_morphology0.59993087
132MP0004134_abnormal_chest_morphology0.59939216
133MP0009278_abnormal_bone_marrow0.59797744
134MP0002177_abnormal_outer_ear0.59003034
135MP0001819_abnormal_immune_cell0.58925856
136MP0003566_abnormal_cell_adhesion0.58716011
137MP0002697_abnormal_eye_size0.58714834
138MP0003936_abnormal_reproductive_system0.58404522
139MP0002405_respiratory_system_inflammati0.58014285
140MP0002006_tumorigenesis0.57340264
141MP0004264_abnormal_extraembryonic_tissu0.57023566
142MP0003943_abnormal_hepatobiliary_system0.56205869
143MP0000477_abnormal_intestine_morphology0.56094196
144MP0002452_abnormal_antigen_presenting0.55396206
145MP0005023_abnormal_wound_healing0.53950085

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.74252400
2Chromsome breakage (HP:0040012)3.98948616
3Reticulocytopenia (HP:0001896)3.59242800
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57241352
5Breast hypoplasia (HP:0003187)3.39902765
6Abnormality of chromosome stability (HP:0003220)3.38311009
7Medulloblastoma (HP:0002885)3.21428431
8Colon cancer (HP:0003003)3.07293005
911 pairs of ribs (HP:0000878)3.00115773
10Meckel diverticulum (HP:0002245)2.92889689
11Degeneration of anterior horn cells (HP:0002398)2.89701934
12Abnormality of the anterior horn cell (HP:0006802)2.89701934
13Patellar aplasia (HP:0006443)2.88565457
14Selective tooth agenesis (HP:0001592)2.86441996
15Myelodysplasia (HP:0002863)2.83960581
16Abnormality of the preputium (HP:0100587)2.83401409
17Abnormality of cells of the erythroid lineage (HP:0012130)2.82095417
18Agnosia (HP:0010524)2.81920123
19Rhabdomyosarcoma (HP:0002859)2.81700219
20Irregular epiphyses (HP:0010582)2.78164458
21Abnormality of the ileum (HP:0001549)2.71975798
22Abnormality of the labia minora (HP:0012880)2.71631223
23Proximal placement of thumb (HP:0009623)2.71618331
24Absent thumb (HP:0009777)2.71058217
25Deviation of the thumb (HP:0009603)2.67902047
26Aplasia/Hypoplasia of the patella (HP:0006498)2.64490167
27Ependymoma (HP:0002888)2.63629006
28Carpal bone hypoplasia (HP:0001498)2.61941567
29Molar tooth sign on MRI (HP:0002419)2.61288562
30Abnormality of midbrain morphology (HP:0002418)2.61288562
31Abnormal number of erythroid precursors (HP:0012131)2.60145245
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.58060515
33Pancreatic cysts (HP:0001737)2.57332966
34Cerebral hypomyelination (HP:0006808)2.56537404
35Aplastic anemia (HP:0001915)2.53850126
36Pancreatic fibrosis (HP:0100732)2.53185265
37Rough bone trabeculation (HP:0100670)2.50824634
38Volvulus (HP:0002580)2.50629315
39Acute myeloid leukemia (HP:0004808)2.48126819
40Supernumerary spleens (HP:0009799)2.46637982
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.46393070
42Abnormality of the renal collecting system (HP:0004742)2.42844056
43Abnormal spermatogenesis (HP:0008669)2.41987801
44Impulsivity (HP:0100710)2.41003151
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.39313556
46Hypoplasia of the fovea (HP:0007750)2.39313556
47Stenosis of the external auditory canal (HP:0000402)2.36928804
48Oligodactyly (hands) (HP:0001180)2.36754402
49Ectopic kidney (HP:0000086)2.35673753
50Glossoptosis (HP:0000162)2.35258680
51Sloping forehead (HP:0000340)2.33703243
52Oral leukoplakia (HP:0002745)2.33046635
53Macrocytic anemia (HP:0001972)2.32247881
54Small intestinal stenosis (HP:0012848)2.31922205
55Duodenal stenosis (HP:0100867)2.31922205
56Absent radius (HP:0003974)2.31818167
57Premature graying of hair (HP:0002216)2.31728717
58Abnormality of the pons (HP:0007361)2.31045988
59Short tibia (HP:0005736)2.29706024
60Pallor (HP:0000980)2.27790055
61Abnormal number of incisors (HP:0011064)2.27677547
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.23810808
63Median cleft lip (HP:0000161)2.18856994
64Hypoplasia of the pons (HP:0012110)2.16637978
65Bone marrow hypocellularity (HP:0005528)2.13923253
66Basal cell carcinoma (HP:0002671)2.12560678
67Absent forearm bone (HP:0003953)2.12443114
68Aplasia involving forearm bones (HP:0009822)2.12443114
69Lymphoma (HP:0002665)2.10571411
70Acute necrotizing encephalopathy (HP:0006965)2.09007832
71Amaurosis fugax (HP:0100576)2.07873560
72Atresia of the external auditory canal (HP:0000413)2.07452053
73Abnormal lung lobation (HP:0002101)2.07098677
74Prominent nose (HP:0000448)2.04625361
75Methylmalonic acidemia (HP:0002912)2.02790232
76Increased CSF lactate (HP:0002490)2.02480771
77True hermaphroditism (HP:0010459)2.00869297
78Missing ribs (HP:0000921)1.99680742
79Abnormality of the fovea (HP:0000493)1.98520081
80Facial hemangioma (HP:0000329)1.98271030
81Abnormality of DNA repair (HP:0003254)1.96570902
82Asplenia (HP:0001746)1.96433270
83Recurrent bronchitis (HP:0002837)1.96031334
84Preaxial hand polydactyly (HP:0001177)1.95370275
85Trismus (HP:0000211)1.95360738
86Bifid tongue (HP:0010297)1.94830496
87Aplasia/Hypoplasia of the sternum (HP:0006714)1.94793748
88Short thumb (HP:0009778)1.94501632
89Increased nuchal translucency (HP:0010880)1.93813158
90Horseshoe kidney (HP:0000085)1.93431692
91Abnormality of the duodenum (HP:0002246)1.93273514
92Thrombocytosis (HP:0001894)1.93160812
93Increased hepatocellular lipid droplets (HP:0006565)1.93156407
94Premature ovarian failure (HP:0008209)1.92367196
95Acute encephalopathy (HP:0006846)1.92306850
96Squamous cell carcinoma (HP:0002860)1.91409437
97Nephronophthisis (HP:0000090)1.91077330
98Intestinal atresia (HP:0011100)1.90664611
99Nephroblastoma (Wilms tumor) (HP:0002667)1.90425785
100Abdominal situs inversus (HP:0003363)1.88959769
101Abnormality of abdominal situs (HP:0011620)1.88959769
102Progressive inability to walk (HP:0002505)1.88949907
103Posterior subcapsular cataract (HP:0007787)1.88918873
104Increased serum lactate (HP:0002151)1.87482592
105Entropion (HP:0000621)1.86338858
106Neoplasm of the pancreas (HP:0002894)1.85395586
107Glioma (HP:0009733)1.84957347
108Triphalangeal thumb (HP:0001199)1.82175763
109Neoplasm of the oral cavity (HP:0100649)1.82156844
110Tracheoesophageal fistula (HP:0002575)1.80823219
111Acute lymphatic leukemia (HP:0006721)1.79976833
112Neoplasm of striated muscle (HP:0009728)1.79957016
113Embryonal renal neoplasm (HP:0011794)1.79562433
114Cleft eyelid (HP:0000625)1.79335454
115Abnormality of the renal cortex (HP:0011035)1.79323653
116Lipid accumulation in hepatocytes (HP:0006561)1.79318747
117Abnormal trabecular bone morphology (HP:0100671)1.78699107
118Abnormality of alanine metabolism (HP:0010916)1.78645073
119Hyperalaninemia (HP:0003348)1.78645073
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78645073
121Abnormality of the astrocytes (HP:0100707)1.78520954
122Astrocytoma (HP:0009592)1.78520954
123Hypoplasia of the radius (HP:0002984)1.77975518
124Muscle fiber atrophy (HP:0100295)1.77148647
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.76596274
126Clubbing of toes (HP:0100760)1.76559878
127Abnormality of cochlea (HP:0000375)1.76338443
128Progressive macrocephaly (HP:0004481)1.76285798
129Cellular immunodeficiency (HP:0005374)1.76040448
130T lymphocytopenia (HP:0005403)1.76014258
131Gastrointestinal atresia (HP:0002589)1.76012958
132Azoospermia (HP:0000027)1.75205661
133Neoplasm of the colon (HP:0100273)1.75111144
134Abnormality of the carotid arteries (HP:0005344)1.74567702
135Small hand (HP:0200055)1.74382036
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.74257127
137Chronic hepatic failure (HP:0100626)1.73865207
138Tongue fasciculations (HP:0001308)1.73768208
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72860837
140Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72769892
141Abnormal mitochondria in muscle tissue (HP:0008316)1.72764233
142Renal cortical cysts (HP:0000803)1.72634260
143Facial cleft (HP:0002006)1.72178984
144IgM deficiency (HP:0002850)1.71974349
145Astigmatism (HP:0000483)1.70895647
146Dandy-Walker malformation (HP:0001305)1.69635222
147Abnormality of methionine metabolism (HP:0010901)1.69471221
148Gaze-evoked nystagmus (HP:0000640)1.68637131
149Hypoplastic pelvis (HP:0008839)1.67632645
150Gonadotropin excess (HP:0000837)1.66797977
151Tubulointerstitial nephritis (HP:0001970)1.66168059
152Microglossia (HP:0000171)1.65434182
153Duplicated collecting system (HP:0000081)1.65066645
154Type I transferrin isoform profile (HP:0003642)1.64698953
155Abnormality of the septum pellucidum (HP:0007375)1.63985573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.32493920
2WEE13.81562173
3BUB13.75572028
4EIF2AK13.18223150
5SRPK13.13978354
6TSSK63.02591018
7CDK122.76628025
8ACVR1B2.59961372
9MKNK12.51537472
10TRIM282.33173416
11MKNK22.33112767
12BRSK22.17930422
13FRK2.04325777
14NEK22.01326675
15CDK71.99396907
16EIF2AK31.95445451
17PLK11.92570800
18ATR1.91312318
19PLK31.86932863
20RPS6KB21.84003686
21TTK1.82080293
22TNIK1.79300686
23VRK21.74853516
24PLK41.69461404
25VRK11.69348314
26AURKB1.64729812
27WNK31.62250432
28BRD41.61406920
29NME21.59854559
30PASK1.56367672
31STK101.48267887
32CHEK11.46592198
33EEF2K1.46286211
34TGFBR11.41425077
35MST41.39155939
36RPS6KA41.38678233
37TAOK31.36870624
38CDK41.33661016
39MAP4K21.30442175
40ZAK1.26969111
41DYRK31.26759354
42ATM1.22869201
43CHEK21.22711629
44PNCK1.22616273
45PLK21.12476818
46STK391.08497808
47AURKA1.06829736
48PIM11.06403412
49STK41.05117362
50NME11.04430342
51EPHA21.00363355
52STK160.99382409
53CDK80.97255659
54MAP2K30.97167730
55CDK20.96939034
56TAF10.94536054
57ALK0.93520328
58TXK0.91583527
59PDK20.90918364
60MAP3K80.89738517
61CDK60.89481523
62SCYL20.88841260
63CSNK2A20.88521689
64TLK10.87537630
65TEC0.86875866
66BRSK10.86593783
67NEK10.84154930
68MAP3K40.80962329
69ERBB30.80726060
70WNK40.80007350
71NEK60.74803203
72EIF2AK20.74411368
73MAP4K10.72789876
74CDK10.72307926
75OXSR10.70846746
76BRAF0.68785658
77MELK0.68442244
78RPS6KA50.68055540
79CSNK2A10.67290935
80PIM20.67033643
81PBK0.66880753
82BMPR1B0.66086174
83CSNK1A1L0.64992497
84CSNK1G30.64677214
85BCR0.64324039
86MAP3K90.62053426
87MET0.60837724
88MAPK130.59746543
89MAP3K30.59498372
90GRK10.57109851
91TESK20.54667752
92CSNK1E0.54652981
93STK30.54284355
94LATS10.53495907
95CSNK1G10.51453652
96NLK0.50812367
97YES10.50363684
98NUAK10.50297206
99CSNK1G20.50149599
100ADRBK20.46250828
101PAK40.46139033
102MAP2K70.45865654
103CLK10.43528896
104CDK90.43211597
105PRKDC0.42665529
106BTK0.42488681
107MAPK140.41610553
108AKT30.41369094
109CHUK0.41359771
110CSNK1D0.41030696
111CCNB10.40691433
112MAP3K120.39142911
113MAP3K100.38911560
114ERBB40.38591291
115RAF10.37743304
116STK240.37214629
117INSRR0.37175956
118MAPKAPK30.36068799
119MARK30.35691946
120PAK10.33462973
121FGFR10.33212341
122PRKACB0.33057578
123CAMK1G0.33012778
124MAPKAPK50.30729421
125RPS6KB10.29771627
126CDK30.29738746
127FLT30.29337669
128STK38L0.28701005
129GSK3B0.28603773
130TRPM70.28500266
131IKBKB0.28065370
132PRKCI0.27145745
133ITK0.25974976
134MAPK10.25540200

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.38589833
2DNA replication_Homo sapiens_hsa030304.30705781
3Mismatch repair_Homo sapiens_hsa034303.83552544
4Spliceosome_Homo sapiens_hsa030403.43745196
5RNA polymerase_Homo sapiens_hsa030203.36613787
6RNA transport_Homo sapiens_hsa030133.26689588
7Ribosome_Homo sapiens_hsa030103.08601009
8Homologous recombination_Homo sapiens_hsa034403.03819616
9Nucleotide excision repair_Homo sapiens_hsa034202.78695478
10Proteasome_Homo sapiens_hsa030502.76094603
11Cell cycle_Homo sapiens_hsa041102.71456222
12Non-homologous end-joining_Homo sapiens_hsa034502.69854641
13Base excision repair_Homo sapiens_hsa034102.65141905
14One carbon pool by folate_Homo sapiens_hsa006702.53172643
15Fanconi anemia pathway_Homo sapiens_hsa034602.50621384
16Basal transcription factors_Homo sapiens_hsa030222.39937610
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39933498
18RNA degradation_Homo sapiens_hsa030182.22452616
19Pyrimidine metabolism_Homo sapiens_hsa002402.22339225
20mRNA surveillance pathway_Homo sapiens_hsa030152.14855532
21Propanoate metabolism_Homo sapiens_hsa006401.55622378
22p53 signaling pathway_Homo sapiens_hsa041151.52598816
23Epstein-Barr virus infection_Homo sapiens_hsa051691.35248072
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33544789
25Purine metabolism_Homo sapiens_hsa002301.27186553
26Oxidative phosphorylation_Homo sapiens_hsa001901.17780701
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17207565
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16368048
29Herpes simplex infection_Homo sapiens_hsa051681.16279401
30Parkinsons disease_Homo sapiens_hsa050121.15660277
31Antigen processing and presentation_Homo sapiens_hsa046121.12277358
32Pyruvate metabolism_Homo sapiens_hsa006201.08361732
33Phototransduction_Homo sapiens_hsa047441.04842700
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02835431
35Systemic lupus erythematosus_Homo sapiens_hsa053221.02340484
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01732473
37Viral carcinogenesis_Homo sapiens_hsa052030.97709839
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97338239
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87634742
40HTLV-I infection_Homo sapiens_hsa051660.87015106
41Thyroid cancer_Homo sapiens_hsa052160.86329664
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85146370
43Oocyte meiosis_Homo sapiens_hsa041140.83978206
44Primary immunodeficiency_Homo sapiens_hsa053400.83877162
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83193312
46Caffeine metabolism_Homo sapiens_hsa002320.81451137
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80948177
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78911717
49MicroRNAs in cancer_Homo sapiens_hsa052060.74783524
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.74178129
51Steroid biosynthesis_Homo sapiens_hsa001000.73398802
52Olfactory transduction_Homo sapiens_hsa047400.71464988
53Butanoate metabolism_Homo sapiens_hsa006500.70273077
54Measles_Homo sapiens_hsa051620.67247304
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66178817
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64922870
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64011377
58Circadian rhythm_Homo sapiens_hsa047100.63834278
59Protein export_Homo sapiens_hsa030600.63467473
60Fatty acid elongation_Homo sapiens_hsa000620.61630474
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58593600
62TGF-beta signaling pathway_Homo sapiens_hsa043500.57686870
63Small cell lung cancer_Homo sapiens_hsa052220.57264288
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56844802
65Hematopoietic cell lineage_Homo sapiens_hsa046400.56539245
66Legionellosis_Homo sapiens_hsa051340.55552023
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53812850
68Metabolic pathways_Homo sapiens_hsa011000.53707512
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52879723
70Allograft rejection_Homo sapiens_hsa053300.52384094
71Alzheimers disease_Homo sapiens_hsa050100.49987737
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.48986437
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.47919348
74Sulfur metabolism_Homo sapiens_hsa009200.47517027
75Influenza A_Homo sapiens_hsa051640.46381289
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45893343
77Vitamin B6 metabolism_Homo sapiens_hsa007500.45842663
78Colorectal cancer_Homo sapiens_hsa052100.45655423
79Nicotine addiction_Homo sapiens_hsa050330.45639570
80Apoptosis_Homo sapiens_hsa042100.45429317
81T cell receptor signaling pathway_Homo sapiens_hsa046600.44984991
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44713774
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.44650074
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42725752
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.42637976
86Taste transduction_Homo sapiens_hsa047420.42383814
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42299713
88Selenocompound metabolism_Homo sapiens_hsa004500.42192688
89Asthma_Homo sapiens_hsa053100.41687149
90Hepatitis B_Homo sapiens_hsa051610.41389517
91Shigellosis_Homo sapiens_hsa051310.41328680
92Graft-versus-host disease_Homo sapiens_hsa053320.40406015
93Tryptophan metabolism_Homo sapiens_hsa003800.40398117
94Folate biosynthesis_Homo sapiens_hsa007900.39392346
95Hippo signaling pathway_Homo sapiens_hsa043900.39268411
96Sulfur relay system_Homo sapiens_hsa041220.38935422
97Pentose phosphate pathway_Homo sapiens_hsa000300.38611815
98Carbon metabolism_Homo sapiens_hsa012000.34926420
99Autoimmune thyroid disease_Homo sapiens_hsa053200.34889377
100Basal cell carcinoma_Homo sapiens_hsa052170.34677190
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.33788645
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33734446
103Pathways in cancer_Homo sapiens_hsa052000.33331306
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33163930
105Regulation of autophagy_Homo sapiens_hsa041400.32961682
106Notch signaling pathway_Homo sapiens_hsa043300.31875176
107Nitrogen metabolism_Homo sapiens_hsa009100.31709722
108Prostate cancer_Homo sapiens_hsa052150.31401072
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31364410
110Peroxisome_Homo sapiens_hsa041460.30950797
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.30839641
112Leishmaniasis_Homo sapiens_hsa051400.30398884
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30311565
114Hedgehog signaling pathway_Homo sapiens_hsa043400.30171201
115Huntingtons disease_Homo sapiens_hsa050160.29340738
116Wnt signaling pathway_Homo sapiens_hsa043100.28925965
117Linoleic acid metabolism_Homo sapiens_hsa005910.28771493
118Ether lipid metabolism_Homo sapiens_hsa005650.28369785
119beta-Alanine metabolism_Homo sapiens_hsa004100.27141223
120Acute myeloid leukemia_Homo sapiens_hsa052210.26168369
121Alcoholism_Homo sapiens_hsa050340.25654051
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25596489
123Adherens junction_Homo sapiens_hsa045200.25202165
124Arginine and proline metabolism_Homo sapiens_hsa003300.24995227
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24883993
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24151762
127N-Glycan biosynthesis_Homo sapiens_hsa005100.22802469
128Ovarian steroidogenesis_Homo sapiens_hsa049130.21730438
129Glutathione metabolism_Homo sapiens_hsa004800.20564314
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.20036688
131Chronic myeloid leukemia_Homo sapiens_hsa052200.19911643
132Type I diabetes mellitus_Homo sapiens_hsa049400.19568997
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19065463
134B cell receptor signaling pathway_Homo sapiens_hsa046620.17958335
135HIF-1 signaling pathway_Homo sapiens_hsa040660.17845998
136Viral myocarditis_Homo sapiens_hsa054160.17676169
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17461844
138Biosynthesis of amino acids_Homo sapiens_hsa012300.17152409
139Cardiac muscle contraction_Homo sapiens_hsa042600.16932949
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16838741
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16598219
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16477998
143Vitamin digestion and absorption_Homo sapiens_hsa049770.13704213
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.11888281
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11819974
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10784337
147TNF signaling pathway_Homo sapiens_hsa046680.10733278
148Tight junction_Homo sapiens_hsa045300.10671938
149Lysine degradation_Homo sapiens_hsa003100.09277543

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