DDX10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phagocytosis, recognition (GO:0006910)8.39984545
2acrosome reaction (GO:0007340)6.01440895
3multicellular organism reproduction (GO:0032504)5.71817161
4fusion of sperm to egg plasma membrane (GO:0007342)5.63373464
5protein targeting to Golgi (GO:0000042)5.54391994
6establishment of protein localization to Golgi (GO:0072600)5.51007045
7retrograde transport, vesicle recycling within Golgi (GO:0000301)4.98515281
8detection of molecule of bacterial origin (GO:0032490)4.88386679
9cell wall macromolecule catabolic process (GO:0016998)4.71329574
10plasma membrane fusion (GO:0045026)4.58537485
11regulation of protein glycosylation (GO:0060049)4.51618874
12positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.50631486
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.41334006
14negative regulation of meiosis (GO:0045835)4.35212167
15regulation of inositol phosphate biosynthetic process (GO:0010919)4.19248941
16protein K11-linked deubiquitination (GO:0035871)4.03783187
17cell wall macromolecule metabolic process (GO:0044036)3.88092199
18regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.74681399
19protein localization to Golgi apparatus (GO:0034067)3.71749306
20positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.70987535
21mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.70987535
22negative regulation of glycoprotein biosynthetic process (GO:0010561)3.69117492
23glycoprotein catabolic process (GO:0006516)3.67911427
24neutrophil mediated immunity (GO:0002446)3.59833892
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56024425
26protein hydroxylation (GO:0018126)3.55039573
27reproduction (GO:0000003)3.54584113
28regulation of sarcomere organization (GO:0060297)3.49421438
29blood vessel maturation (GO:0001955)3.45024952
30cellular response to ethanol (GO:0071361)3.41744926
31microglial cell activation (GO:0001774)3.36162164
32myeloid leukocyte mediated immunity (GO:0002444)3.27878359
33photoreceptor cell maintenance (GO:0045494)3.23220895
34macrophage activation (GO:0042116)3.19353468
35regulation of B cell receptor signaling pathway (GO:0050855)3.16859505
36intraciliary transport (GO:0042073)3.13753600
37regulation of establishment of cell polarity (GO:2000114)3.10726959
38regulation of protein kinase A signaling (GO:0010738)3.09354544
39histone mRNA catabolic process (GO:0071044)3.03400197
40neural tube formation (GO:0001841)3.00674758
41negative regulation of cAMP-mediated signaling (GO:0043951)3.00557324
42I-kappaB phosphorylation (GO:0007252)2.94660093
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93615112
44positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.87424478
45macrophage activation involved in immune response (GO:0002281)2.79370925
46positive regulation of myoblast differentiation (GO:0045663)2.77872050
47negative regulation of mast cell activation (GO:0033004)2.74074572
48intra-Golgi vesicle-mediated transport (GO:0006891)2.71852947
49secretory granule organization (GO:0033363)2.69793309
50DNA integration (GO:0015074)2.69637976
51cellular extravasation (GO:0045123)2.68539254
52positive regulation of mitochondrial membrane permeability (GO:0035794)2.68497144
53regulation of interferon-beta biosynthetic process (GO:0045357)2.68395223
54positive regulation of erythrocyte differentiation (GO:0045648)2.66427344
55detection of external biotic stimulus (GO:0098581)2.66158338
56positive regulation of monocyte chemotaxis (GO:0090026)2.65672133
57negative regulation of meiotic cell cycle (GO:0051447)2.62481596
58regulation of interleukin-6 biosynthetic process (GO:0045408)2.60141053
59phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.59090560
60negative regulation of glycoprotein metabolic process (GO:1903019)2.56853808
61negative regulation of lipase activity (GO:0060192)2.54091860
62iron ion import (GO:0097286)2.52773002
63response to peptidoglycan (GO:0032494)2.52751231
64intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.52618197
65T-helper cell differentiation (GO:0042093)2.52295936
66CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.52295936
67regulation of mast cell activation (GO:0033003)2.51674506
68protein targeting to vacuole (GO:0006623)2.51002293
69protein targeting to lysosome (GO:0006622)2.51002293
70establishment of protein localization to vacuole (GO:0072666)2.51002293
71regulation of mitochondrial depolarization (GO:0051900)2.50142335
72myeloid cell activation involved in immune response (GO:0002275)2.49151397
73retina vasculature morphogenesis in camera-type eye (GO:0061299)2.48435170
74mast cell degranulation (GO:0043303)2.48276527
75mast cell activation involved in immune response (GO:0002279)2.48276527
76phospholipid homeostasis (GO:0055091)2.48003684
77regulation of establishment or maintenance of cell polarity (GO:0032878)2.47687787
78positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.47452399
79histone H2A acetylation (GO:0043968)2.47019355
80positive regulation of vasculogenesis (GO:2001214)2.45994507
81regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.45930546
82viral mRNA export from host cell nucleus (GO:0046784)2.44747605
83positive regulation of mast cell degranulation (GO:0043306)2.43566930
84positive regulation of mast cell activation involved in immune response (GO:0033008)2.43566930
85positive regulation of interleukin-1 beta secretion (GO:0050718)2.41997676
86peptidyl-proline hydroxylation (GO:0019511)2.41634268
87sphingoid metabolic process (GO:0046519)2.40678495
88negative regulation of interleukin-12 production (GO:0032695)2.40463895
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.40173097
90negative regulation of protein activation cascade (GO:2000258)2.40042641
91positive regulation of interleukin-1 production (GO:0032732)2.37747409
92regulation of protein polyubiquitination (GO:1902914)2.37597509
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37530905
94positive regulation of mast cell activation (GO:0033005)2.37279145
95negative regulation of complement activation (GO:0045916)2.36657191
96positive regulation by organism of defense response of other organism involved in symbiotic interact2.34947877
97modulation by symbiont of host immune response (GO:0052553)2.34947877
98positive regulation by symbiont of host defense response (GO:0052509)2.34947877
99modulation by symbiont of host defense response (GO:0052031)2.34947877
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34947877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14531952
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78198634
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76826526
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.74248762
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68529900
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.61325926
7VDR_22108803_ChIP-Seq_LS180_Human2.49461898
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26389396
9IGF1R_20145208_ChIP-Seq_DFB_Human2.21392979
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16019738
11TAF15_26573619_Chip-Seq_HEK293_Human2.13933556
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09373955
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.08208893
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.03782933
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00542060
16P300_19829295_ChIP-Seq_ESCs_Human1.94331011
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90521747
18GBX2_23144817_ChIP-Seq_PC3_Human1.84644755
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83947686
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82563625
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.77512512
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75443444
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74937793
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.73357615
25ER_23166858_ChIP-Seq_MCF-7_Human1.72563957
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72279675
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.71925000
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.71378802
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68179800
30SCL_19346495_ChIP-Seq_HPC-7_Human1.66991128
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62753409
32ZNF274_21170338_ChIP-Seq_K562_Hela1.60828660
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58907150
34BCAT_22108803_ChIP-Seq_LS180_Human1.50521737
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.49481967
36ELK1_19687146_ChIP-ChIP_HELA_Human1.48521079
37EWS_26573619_Chip-Seq_HEK293_Human1.47014978
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.46466277
39P53_22127205_ChIP-Seq_FIBROBLAST_Human1.46302396
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46254415
41STAT3_23295773_ChIP-Seq_U87_Human1.46082643
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45651518
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45283204
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43041878
45FUS_26573619_Chip-Seq_HEK293_Human1.42661080
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42238555
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42086785
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40117511
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39160771
50TCF4_23295773_ChIP-Seq_U87_Human1.38712789
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37752079
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.36986772
53VDR_24787735_ChIP-Seq_THP-1_Human1.34830492
54TP53_16413492_ChIP-PET_HCT116_Human1.34349112
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32002063
56SMAD4_21799915_ChIP-Seq_A2780_Human1.31489753
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30731329
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30412267
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30024805
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30024805
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.29629745
62CDX2_22108803_ChIP-Seq_LS180_Human1.28361115
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27293563
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26950057
65P53_22387025_ChIP-Seq_ESCs_Mouse1.26848671
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26751635
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.26620733
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.25041945
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24944814
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23631383
71GATA3_26560356_Chip-Seq_TH2_Human1.23600025
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23393109
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23146426
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22824113
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.21247243
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19376992
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19263650
78RUNX_20019798_ChIP-Seq_JUKART_Human1.17180365
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17065022
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16806833
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16460127
82BRD4_25478319_ChIP-Seq_HGPS_Human1.15380894
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15170033
84CBP_20019798_ChIP-Seq_JUKART_Human1.15024219
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15024219
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14199893
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14149036
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13803663
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.12138293
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12110995
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11818939
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11818939
93AR_25329375_ChIP-Seq_VCAP_Human1.10881886
94NANOG_19829295_ChIP-Seq_ESCs_Human1.10725910
95SOX2_19829295_ChIP-Seq_ESCs_Human1.10725910
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09599339
97CJUN_26792858_Chip-Seq_BT549_Human1.09513740
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.08633810
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07494593
100RUNX2_22187159_ChIP-Seq_PCA_Human1.06925528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage9.19725553
2MP0000569_abnormal_digit_pigmentation5.51711869
3MP0008877_abnormal_DNA_methylation3.83430910
4MP0003787_abnormal_imprinting3.52059991
5MP0003950_abnormal_plasma_membrane3.17790503
6MP0001986_abnormal_taste_sensitivity2.82138354
7MP0003724_increased_susceptibility_to2.58852288
8MP0003221_abnormal_cardiomyocyte_apopto2.55783855
9MP0006082_CNS_inflammation2.31753319
10MP0009697_abnormal_copulation2.19069343
11MP0004510_myositis2.14112419
12MP0004043_abnormal_pH_regulation2.07151836
13MP0005410_abnormal_fertilization1.98531508
14MP0008260_abnormal_autophagy1.94271409
15MP0004883_abnormal_blood_vessel1.92524628
16MP0004484_altered_response_of1.88983180
17MP0000015_abnormal_ear_pigmentation1.80260086
18MP0005164_abnormal_response_to1.74740359
19MP0003195_calcinosis1.71804345
20MP0003567_abnormal_fetal_cardiomyocyte1.63780196
21MP0003828_pulmonary_edema1.63723179
22MP0005174_abnormal_tail_pigmentation1.61217443
23MP0004147_increased_porphyrin_level1.60357997
24MP0010352_gastrointestinal_tract_polyps1.57170405
25MP0002419_abnormal_innate_immunity1.50676781
26MP0000372_irregular_coat_pigmentation1.50511188
27MP0003656_abnormal_erythrocyte_physiolo1.49392102
28MP0002090_abnormal_vision1.34153462
29MP0001835_abnormal_antigen_presentation1.33601324
30MP0000427_abnormal_hair_cycle1.32874217
31MP0003172_abnormal_lysosome_physiology1.32032144
32MP0002148_abnormal_hypersensitivity_rea1.30255244
33MP0002723_abnormal_immune_serum1.29229157
34MP0009764_decreased_sensitivity_to1.27037746
35MP0005551_abnormal_eye_electrophysiolog1.20258369
36MP0001800_abnormal_humoral_immune1.15554588
37MP0003045_fibrosis1.15324262
38MP0005253_abnormal_eye_physiology1.13013999
39MP0005310_abnormal_salivary_gland1.12021309
40MP0005408_hypopigmentation1.09043404
41MP0004381_abnormal_hair_follicle1.07412310
42MP0003303_peritoneal_inflammation1.02183101
43MP0005376_homeostasis/metabolism_phenot0.97492352
44MP0002166_altered_tumor_susceptibility0.97428494
45MP0005584_abnormal_enzyme/coenzyme_acti0.97144185
46MP0005075_abnormal_melanosome_morpholog0.96090151
47MP0002168_other_aberrant_phenotype0.95597122
48MP0001851_eye_inflammation0.95345356
49MP0003121_genomic_imprinting0.94946948
50MP0002452_abnormal_antigen_presenting0.93247315
51MP0001879_abnormal_lymphatic_vessel0.92432301
52MP0001845_abnormal_inflammatory_respons0.92416577
53MP0001545_abnormal_hematopoietic_system0.91967459
54MP0005397_hematopoietic_system_phenotyp0.91967459
55MP0005187_abnormal_penis_morphology0.91187573
56MP0001853_heart_inflammation0.89685361
57MP0002420_abnormal_adaptive_immunity0.89358395
58MP0002006_tumorigenesis0.88994417
59MP0002332_abnormal_exercise_endurance0.87380742
60MP0002405_respiratory_system_inflammati0.86741005
61MP0001819_abnormal_immune_cell0.86607571
62MP0002132_abnormal_respiratory_system0.86134938
63MP0000767_abnormal_smooth_muscle0.85819207
64MP0001873_stomach_inflammation0.84571409
65MP0003763_abnormal_thymus_physiology0.81905145
66MP0005025_abnormal_response_to0.81325458
67MP0008469_abnormal_protein_level0.80377371
68MP0009785_altered_susceptibility_to0.80278395
69MP0000249_abnormal_blood_vessel0.79422161
70MP0001486_abnormal_startle_reflex0.78917665
71MP0000371_diluted_coat_color0.75264083
72MP0000749_muscle_degeneration0.73843124
73MP0005171_absent_coat_pigmentation0.71055293
74MP0003633_abnormal_nervous_system0.70405123
75MP0004742_abnormal_vestibular_system0.70112969
76MP0002277_abnormal_respiratory_mucosa0.68241999
77MP0002138_abnormal_hepatobiliary_system0.66753720
78MP0000343_altered_response_to0.65866478
79MP0005266_abnormal_metabolism0.64439870
80MP0010155_abnormal_intestine_physiology0.62846853
81MP0003011_delayed_dark_adaptation0.62638887
82MP0005000_abnormal_immune_tolerance0.61591622
83MP0001790_abnormal_immune_system0.61014226
84MP0005387_immune_system_phenotype0.61014226
85MP0005451_abnormal_body_composition0.60790838
86MP0008057_abnormal_DNA_replication0.60440530
87MP0000685_abnormal_immune_system0.59707970
88MP0005464_abnormal_platelet_physiology0.58933823
89MP0001984_abnormal_olfaction0.57020777
90MP0005395_other_phenotype0.57012354
91MP0005666_abnormal_adipose_tissue0.56547137
92MP0000716_abnormal_immune_system0.55961025
93MP0003448_altered_tumor_morphology0.55878768
94MP0002396_abnormal_hematopoietic_system0.54886739
95MP0000230_abnormal_systemic_arterial0.54815321
96MP0002722_abnormal_immune_system0.54159687
97MP0003279_aneurysm0.52817180
98MP0000689_abnormal_spleen_morphology0.52601325
99MP0000609_abnormal_liver_physiology0.52003631
100MP0002398_abnormal_bone_marrow0.51640301

Predicted human phenotypes

RankGene SetZ-score
1Decreased central vision (HP:0007663)4.24447332
2Recurrent gram-negative bacterial infections (HP:0005420)4.17695462
3Medial flaring of the eyebrow (HP:0010747)4.06172663
4Cone-rod dystrophy (HP:0000548)3.69241891
5Congenital primary aphakia (HP:0007707)3.64817440
6Adactyly (HP:0009776)3.61661108
7Gait imbalance (HP:0002141)3.54953482
8Nephrogenic diabetes insipidus (HP:0009806)3.35543668
9Stenosis of the external auditory canal (HP:0000402)3.19345729
10Renal cortical cysts (HP:0000803)3.17292538
11Spontaneous hematomas (HP:0007420)3.16102619
12Intestinal atresia (HP:0011100)3.15127621
13Abnormality of alanine metabolism (HP:0010916)3.03731253
14Hyperalaninemia (HP:0003348)3.03731253
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03731253
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94707988
17Recurrent bronchitis (HP:0002837)2.88842809
18Abnormality of the renal cortex (HP:0011035)2.86050654
19Chronic sinusitis (HP:0011109)2.82094776
20Genital tract atresia (HP:0001827)2.72844955
21Abnormality of T cell number (HP:0011839)2.71183131
22Congenital stationary night blindness (HP:0007642)2.70881236
23Gaze-evoked nystagmus (HP:0000640)2.68719652
24Recurrent bacterial skin infections (HP:0005406)2.67991221
25Poor coordination (HP:0002370)2.67213347
26Pancreatic fibrosis (HP:0100732)2.66136573
27Pancreatic cysts (HP:0001737)2.65100893
28T lymphocytopenia (HP:0005403)2.63766397
29Macular degeneration (HP:0000608)2.62154849
30Portal hypertension (HP:0001409)2.61774412
31Chronic diarrhea (HP:0002028)2.55911708
32Vaginal atresia (HP:0000148)2.53422690
33Attenuation of retinal blood vessels (HP:0007843)2.52350539
34Retrobulbar optic neuritis (HP:0100654)2.42963518
35Optic neuritis (HP:0100653)2.42963518
36Conjunctival telangiectasia (HP:0000524)2.41266265
37Chronic mucocutaneous candidiasis (HP:0002728)2.39119411
38Recurrent cutaneous fungal infections (HP:0011370)2.39119411
39Abnormality of the hepatic vasculature (HP:0006707)2.38286024
40Recurrent abscess formation (HP:0002722)2.33901958
41Abnormality of proline metabolism (HP:0010907)2.29867272
42Hydroxyprolinuria (HP:0003080)2.29867272
43Hemoptysis (HP:0002105)2.29503833
44Hypochromic microcytic anemia (HP:0004840)2.28042675
45Congenital hepatic fibrosis (HP:0002612)2.27140788
46Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26517688
47Clonus (HP:0002169)2.24866571
48Papillary thyroid carcinoma (HP:0002895)2.23789179
49Thyroiditis (HP:0100646)2.22578455
50Molar tooth sign on MRI (HP:0002419)2.16831467
51Abnormality of midbrain morphology (HP:0002418)2.16831467
52Ependymoma (HP:0002888)2.16796993
53Esophageal varix (HP:0002040)2.16443593
54Arterial tortuosity (HP:0005116)2.14351943
55Rhabdomyosarcoma (HP:0002859)2.12041046
56Orchitis (HP:0100796)2.11363935
57Amyotrophic lateral sclerosis (HP:0007354)2.10409086
58Abnormal hair whorl (HP:0010721)2.04976163
59Resting tremor (HP:0002322)2.04359715
60Agnosia (HP:0010524)2.04198661
61Volvulus (HP:0002580)2.03877973
62Short chin (HP:0000331)2.03632008
63Abnormality of the renal medulla (HP:0100957)2.00394230
64Ascites (HP:0001541)2.00311744
65Chronic otitis media (HP:0000389)1.99743385
66Myositis (HP:0100614)1.98435284
67Gingival bleeding (HP:0000225)1.97218700
68Recurrent skin infections (HP:0001581)1.96330824
69Aqueductal stenosis (HP:0002410)1.94609406
70Abnormality of the astrocytes (HP:0100707)1.94064176
71Astrocytoma (HP:0009592)1.94064176
72Ankle clonus (HP:0011448)1.93799954
73Abnormality of chromosome stability (HP:0003220)1.93323905
74Enlarged kidneys (HP:0000105)1.92696394
75Abnormal rod and cone electroretinograms (HP:0008323)1.92201276
76Tubular atrophy (HP:0000092)1.91686383
77Chin dimple (HP:0010751)1.90552762
78Short foot (HP:0001773)1.89876267
79Leukocytosis (HP:0001974)1.89732012
80Increased neuronal autofluorescent lipopigment (HP:0002074)1.87632868
81Aplasia/Hypoplasia of the lens (HP:0008063)1.87101140
82Amyloidosis (HP:0011034)1.87042778
83Stomatitis (HP:0010280)1.86106467
84Bony spicule pigmentary retinopathy (HP:0007737)1.84950494
85Abnormality of the periventricular white matter (HP:0002518)1.84434711
86Hematochezia (HP:0002573)1.83600913
87Colon cancer (HP:0003003)1.82256319
88Hypothermia (HP:0002045)1.82237624
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81260086
90Constricted visual fields (HP:0001133)1.80644577
91Bronchitis (HP:0012387)1.78766304
92Keratoconjunctivitis (HP:0001096)1.77949377
93Vascular tortuosity (HP:0004948)1.77721109
94Broad foot (HP:0001769)1.75883064
95Epidermoid cyst (HP:0200040)1.75831582
96Abnormality of macular pigmentation (HP:0008002)1.74939611
97Nephronophthisis (HP:0000090)1.74343175
98Gastrointestinal atresia (HP:0002589)1.72772760
99Decreased testicular size (HP:0008734)1.72056703
100Nephrotic syndrome (HP:0000100)1.71379944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.25616928
2MAP3K134.00394376
3BMPR1B3.55326185
4CCNB12.88075158
5PIK3CG2.68319146
6ACVR1B2.57834890
7NUAK12.49737368
8PKN22.08460407
9RPS6KA41.97829126
10FES1.95411882
11PTK2B1.90419271
12KIT1.89335994
13TAOK31.83124220
14MAP3K141.77234228
15FLT31.76335727
16MAPK131.76286035
17NTRK31.64788223
18PINK11.49595028
19IRAK41.42001038
20MAP3K21.39419162
21SGK21.39028348
22TXK1.33672787
23PDK21.31534082
24FGR1.30845125
25BRSK21.29272004
26IRAK11.26655216
27MAP4K21.23750446
28PAK31.20735020
29WEE11.11924058
30IRAK31.11450179
31MAP3K71.09809068
32TEC1.09343250
33CSK1.07874863
34ADRBK11.06914323
35SYK1.05651263
36FGFR11.02547288
37YES10.99848040
38PRKAA20.99256149
39MAP2K30.97762345
40RIPK40.96375030
41CLK10.95848913
42MUSK0.92167888
43BLK0.91790722
44WNK30.90307163
45TGFBR10.90183800
46MAP3K60.89860100
47KSR10.88104331
48BMPR20.86117296
49IRAK20.86034554
50TGFBR20.86015964
51PLK20.84226811
52RAF10.82387236
53SGK30.78726335
54IKBKB0.76645261
55TIE10.75789479
56PAK60.75623018
57STK110.75106061
58STK30.74629445
59IKBKE0.74358291
60JAK30.74194375
61NEK60.73905146
62MKNK20.73666343
63DYRK30.73573611
64DAPK20.73034910
65NEK90.69631638
66PRKCE0.69207101
67ADRBK20.69155889
68OBSCN0.66881629
69GRK10.65659336
70EIF2AK30.65656942
71EGFR0.64032057
72KSR20.63521991
73SGK2230.62559539
74SGK4940.62559539
75MAP3K120.60315051
76CAMK40.59193996
77MARK30.59088987
78MAP3K50.58991208
79HCK0.57874109
80GRK50.54397258
81PRKD30.51525464
82BTK0.51268765
83JAK20.50474360
84ITK0.50048384
85TBK10.49174936
86LYN0.46056459
87TNK20.45738638
88ERBB20.42955724
89PIK3CA0.41479807
90TRPM70.41182074
91NLK0.39870102
92PRKCQ0.38888584
93CAMK2A0.38416014
94CSF1R0.37294181
95WNK10.36396913
96CDK40.35882845
97CSNK1D0.35479067
98MAP2K40.34602673
99FGFR20.34385840
100BCR0.34323000

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.08935140
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.93435947
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.22758928
4Legionellosis_Homo sapiens_hsa051342.15831486
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10059682
6Complement and coagulation cascades_Homo sapiens_hsa046101.99749308
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95780081
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91597844
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90895034
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61119108
11Leishmaniasis_Homo sapiens_hsa051401.59968319
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59565802
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58868366
14Propanoate metabolism_Homo sapiens_hsa006401.56632837
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51415191
16Osteoclast differentiation_Homo sapiens_hsa043801.50495366
17Tuberculosis_Homo sapiens_hsa051521.48116817
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.47661529
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47588533
20Ether lipid metabolism_Homo sapiens_hsa005651.42947284
21Hematopoietic cell lineage_Homo sapiens_hsa046401.39854610
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39762147
23ABC transporters_Homo sapiens_hsa020101.35385076
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35033295
25Butanoate metabolism_Homo sapiens_hsa006501.30554492
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29267500
27Caffeine metabolism_Homo sapiens_hsa002321.28998334
28Platelet activation_Homo sapiens_hsa046111.28849421
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26565308
30Fatty acid biosynthesis_Homo sapiens_hsa000611.26425928
31Taste transduction_Homo sapiens_hsa047421.19501667
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10133789
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08757218
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.08090289
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07937477
36beta-Alanine metabolism_Homo sapiens_hsa004101.05384325
37Pertussis_Homo sapiens_hsa051331.04497304
38African trypanosomiasis_Homo sapiens_hsa051431.04448014
39Morphine addiction_Homo sapiens_hsa050321.03487477
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00534340
41Staphylococcus aureus infection_Homo sapiens_hsa051501.00155495
42TNF signaling pathway_Homo sapiens_hsa046680.99908055
43Protein export_Homo sapiens_hsa030600.99342775
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98619898
45PPAR signaling pathway_Homo sapiens_hsa033200.98117334
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95586187
47HIF-1 signaling pathway_Homo sapiens_hsa040660.94678316
48Chemokine signaling pathway_Homo sapiens_hsa040620.89999789
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.87624959
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.85218954
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.84795337
52Nitrogen metabolism_Homo sapiens_hsa009100.84085709
53Arachidonic acid metabolism_Homo sapiens_hsa005900.81433281
54Salmonella infection_Homo sapiens_hsa051320.81274545
55Malaria_Homo sapiens_hsa051440.80523358
56Glycerolipid metabolism_Homo sapiens_hsa005610.79476448
57Glutamatergic synapse_Homo sapiens_hsa047240.78590969
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74254151
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74161158
60p53 signaling pathway_Homo sapiens_hsa041150.71100729
61Toxoplasmosis_Homo sapiens_hsa051450.71080016
62Fanconi anemia pathway_Homo sapiens_hsa034600.67948377
63Circadian rhythm_Homo sapiens_hsa047100.67890021
64Rheumatoid arthritis_Homo sapiens_hsa053230.64967286
65Serotonergic synapse_Homo sapiens_hsa047260.64692011
66Linoleic acid metabolism_Homo sapiens_hsa005910.63830387
67FoxO signaling pathway_Homo sapiens_hsa040680.63779298
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62992480
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.62651076
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61902424
71Phototransduction_Homo sapiens_hsa047440.60510356
72Homologous recombination_Homo sapiens_hsa034400.59803639
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57458463
74Regulation of autophagy_Homo sapiens_hsa041400.57242221
75GABAergic synapse_Homo sapiens_hsa047270.57038696
76Basal transcription factors_Homo sapiens_hsa030220.53324515
77Phagosome_Homo sapiens_hsa041450.52353092
78Renin secretion_Homo sapiens_hsa049240.52097307
79RNA degradation_Homo sapiens_hsa030180.51995430
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.51367620
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.51165216
82Lysosome_Homo sapiens_hsa041420.50729765
83Olfactory transduction_Homo sapiens_hsa047400.50343735
84B cell receptor signaling pathway_Homo sapiens_hsa046620.50313302
85Sphingolipid metabolism_Homo sapiens_hsa006000.49564991
86Influenza A_Homo sapiens_hsa051640.48182111
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48094538
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48042364
89Pancreatic cancer_Homo sapiens_hsa052120.46943731
90Lysine degradation_Homo sapiens_hsa003100.46697562
91Graft-versus-host disease_Homo sapiens_hsa053320.44769515
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.44417910
93Ras signaling pathway_Homo sapiens_hsa040140.44375940
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43123548
95Oocyte meiosis_Homo sapiens_hsa041140.42935837
96Peroxisome_Homo sapiens_hsa041460.42726522
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42678489
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42572435
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41637534
100Shigellosis_Homo sapiens_hsa051310.40682502

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