ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	5.88462424
2	pseudouridine synthesis (GO:0001522)	5.33217270
3	chaperone-mediated protein transport (GO:0072321)	5.21027688
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.03831277
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.93712625
6	viral transcription (GO:0019083)	4.70574731
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.66674249
8	translational termination (GO:0006415)	4.62682380
9	ATP synthesis coupled proton transport (GO:0015986)	4.28313018
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28313018
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.04805746
12	cotranslational protein targeting to membrane (GO:0006613)	4.03506672
13	maturation of SSU-rRNA (GO:0030490)	3.96610906
14	negative regulation of multicellular organism growth (GO:0040015)	3.96326976
15	translational elongation (GO:0006414)	3.95034394
16	protein targeting to ER (GO:0045047)	3.89087794
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.77095293
18	positive regulation of gastrulation (GO:2000543)	3.67563377
19	spliceosomal complex assembly (GO:0000245)	3.61163484
20	cellular ketone body metabolic process (GO:0046950)	3.60805570
21	cellular protein complex disassembly (GO:0043624)	3.59142498
22	protein localization to endoplasmic reticulum (GO:0070972)	3.56452865
23	lung-associated mesenchyme development (GO:0060484)	3.55532210
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.50490522
25	NADH dehydrogenase complex assembly (GO:0010257)	3.50490522
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.50490522
27	C4-dicarboxylate transport (GO:0015740)	3.45634652
28	ribosomal small subunit assembly (GO:0000028)	3.39759664
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.34319382
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30452222
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28396747
32	ribosomal large subunit biogenesis (GO:0042273)	3.27958226
33	neuron fate determination (GO:0048664)	3.26107653
34	auditory receptor cell stereocilium organization (GO:0060088)	3.25300620
35	protein K6-linked ubiquitination (GO:0085020)	3.24849282
36	sex differentiation (GO:0007548)	3.23473582
37	ribosomal small subunit biogenesis (GO:0042274)	3.23425740
38	protein complex biogenesis (GO:0070271)	3.22320065
39	viral life cycle (GO:0019058)	3.20947098
40	ketone body metabolic process (GO:1902224)	3.18902245
41	chromatin remodeling at centromere (GO:0031055)	3.17616455
42	DNA integration (GO:0015074)	3.16201582
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.15663191
44	response to X-ray (GO:0010165)	3.15194443
45	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.15129203
46	DNA replication checkpoint (GO:0000076)	3.13037141
47	left/right axis specification (GO:0070986)	3.12074207
48	nucleoside diphosphate catabolic process (GO:0009134)	3.11404141
49	protein neddylation (GO:0045116)	3.09053550
50	protein complex disassembly (GO:0043241)	3.04818275
51	CENP-A containing nucleosome assembly (GO:0034080)	3.04433192
52	alternative mRNA splicing, via spliceosome (GO:0000380)	3.03715192
53	electron transport chain (GO:0022900)	3.02399520
54	regulation of mitochondrial translation (GO:0070129)	3.02204375
55	urogenital system development (GO:0001655)	2.99912494
56	outer ear morphogenesis (GO:0042473)	2.99132388
57	ATP biosynthetic process (GO:0006754)	2.98978739
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98309631
59	respiratory electron transport chain (GO:0022904)	2.97497923
60	translational initiation (GO:0006413)	2.94956073
61	male meiosis I (GO:0007141)	2.93791943
62	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.91988185
63	macromolecular complex disassembly (GO:0032984)	2.87840925
64	otic vesicle formation (GO:0030916)	2.84144892
65	alanine transport (GO:0032328)	2.83854664
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.83708158
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.80465803
68	spliceosomal snRNP assembly (GO:0000387)	2.78558370
69	regulation of establishment of cell polarity (GO:2000114)	2.74025139
70	inner ear receptor stereocilium organization (GO:0060122)	2.72368729
71	regulation of sarcomere organization (GO:0060297)	2.68259641
72	DNA ligation (GO:0006266)	2.67952641
73	lactate metabolic process (GO:0006089)	2.67677371
74	behavioral response to nicotine (GO:0035095)	2.67661156
75	peptidyl-histidine modification (GO:0018202)	2.66278014
76	rRNA modification (GO:0000154)	2.62545105
77	fucose catabolic process (GO:0019317)	2.61621190
78	L-fucose metabolic process (GO:0042354)	2.61621190
79	L-fucose catabolic process (GO:0042355)	2.61621190
80	tRNA processing (GO:0008033)	2.61322815
81	indolalkylamine metabolic process (GO:0006586)	2.60780484
82	nonmotile primary cilium assembly (GO:0035058)	2.59951207
83	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59642265
84	termination of RNA polymerase III transcription (GO:0006386)	2.59642265
85	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59246236
86	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59246236
87	spindle assembly involved in mitosis (GO:0090307)	2.58291219
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.58028066
89	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.57621871
90	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.57562721
91	vitamin biosynthetic process (GO:0009110)	2.57281899
92	branched-chain amino acid catabolic process (GO:0009083)	2.56370306
93	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.55991112
94	meiosis I (GO:0007127)	2.55530710
95	translation (GO:0006412)	2.54661629
96	tryptophan metabolic process (GO:0006568)	2.53564155
97	intracellular protein transmembrane import (GO:0044743)	2.53500486
98	recombinational repair (GO:0000725)	2.53220073
99	reflex (GO:0060004)	2.51842881
100	somite rostral/caudal axis specification (GO:0032525)	2.51495211

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.31020139
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.04340895
3	VDR_22108803_ChIP-Seq_LS180_Human	4.27287216
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.95590352
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.79124664
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.74750996
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.64417640
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.55798086
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49004007
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.38537330
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.34986987
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25940531
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.25638343
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.21155962
15	FUS_26573619_Chip-Seq_HEK293_Human	2.17636847
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10543682
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.95184494
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94044381
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92916365
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85134984
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84076371
22	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.80618462
23	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.73054521
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.64123525
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62639765
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61693094
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.61371026
28	EWS_26573619_Chip-Seq_HEK293_Human	1.59721428
29	P300_19829295_ChIP-Seq_ESCs_Human	1.59029066
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56625966
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.53395455
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52498120
33	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.50284991
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.49479403
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.48621316
36	VDR_23849224_ChIP-Seq_CD4+_Human	1.48104249
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.45108723
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44506122
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43310812
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42384906
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41092724
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.36405647
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35710770
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34271270
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.33690969
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.30385147
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29419623
48	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.27763104
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26617932
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23136639
51	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21261381
52	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.21163619
53	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20665060
54	GATA1_22025678_ChIP-Seq_K562_Human	1.18545793
55	E2F7_22180533_ChIP-Seq_HELA_Human	1.14760974
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14652059
57	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14343276
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14304777
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14304777
60	AR_20517297_ChIP-Seq_VCAP_Human	1.12783624
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12551651
62	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.11065910
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11000008
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10339573
65	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.09319029
66	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06052066
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05384045
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05045823
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04975520
70	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04773865
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02989483
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02989483
73	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.01609830
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01498447
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99199395
76	CBP_20019798_ChIP-Seq_JUKART_Human	0.98892736
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98892736
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98660047
79	PHF8_20622853_ChIP-Seq_HELA_Human	0.98534741
80	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97968277
81	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97271961
82	TTF2_22483619_ChIP-Seq_HELA_Human	0.96588787
83	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94524594
84	AR_25329375_ChIP-Seq_VCAP_Human	0.93856553
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93807724
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93244647
87	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.93092040
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92847569
89	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92835442
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.92754020
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92658981
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92321892
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92189857
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92070776
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90808041
96	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.90251459
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89655640
98	TCF4_23295773_ChIP-Seq_U87_Human	0.87684611
99	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.86438779
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.86307381

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.88662861
2	MP0002102_abnormal_ear_morphology	3.44580361
3	MP0003136_yellow_coat_color	3.09204846
4	MP0002837_dystrophic_cardiac_calcinosis	2.84429581
5	MP0003283_abnormal_digestive_organ	2.68223790
6	MP0004147_increased_porphyrin_level	2.62628108
7	MP0003938_abnormal_ear_development	2.56176868
8	MP0004145_abnormal_muscle_electrophysio	2.49192116
9	MP0006292_abnormal_olfactory_placode	2.37246907
10	MP0005253_abnormal_eye_physiology	2.22293806
11	MP0002234_abnormal_pharynx_morphology	2.16000571
12	MP0003787_abnormal_imprinting	1.98263470
13	MP0002736_abnormal_nociception_after	1.94768871
14	MP0000049_abnormal_middle_ear	1.91228131
15	MP0001984_abnormal_olfaction	1.90729400
16	MP0003937_abnormal_limbs/digits/tail_de	1.87850860
17	MP0000372_irregular_coat_pigmentation	1.84532154
18	MP0009379_abnormal_foot_pigmentation	1.82223784
19	MP0004742_abnormal_vestibular_system	1.80276074
20	MP0001986_abnormal_taste_sensitivity	1.79344506
21	MP0010094_abnormal_chromosome_stability	1.78061750
22	MP0003878_abnormal_ear_physiology	1.76831568
23	MP0005377_hearing/vestibular/ear_phenot	1.76831568
24	MP0000026_abnormal_inner_ear	1.76332815
25	MP0009046_muscle_twitch	1.72659919
26	MP0004885_abnormal_endolymph	1.67103799
27	MP0005645_abnormal_hypothalamus_physiol	1.63704945
28	MP0003011_delayed_dark_adaptation	1.59757626
29	MP0001968_abnormal_touch/_nociception	1.59305445
30	MP0003195_calcinosis	1.54360733
31	MP0000631_abnormal_neuroendocrine_gland	1.50599390
32	MP0005551_abnormal_eye_electrophysiolog	1.49287436
33	MP0001501_abnormal_sleep_pattern	1.41349234
34	MP0003880_abnormal_central_pattern	1.40495409
35	MP0004142_abnormal_muscle_tone	1.40062254
36	MP0009745_abnormal_behavioral_response	1.39880436
37	MP0003137_abnormal_impulse_conducting	1.39430232
38	MP0002282_abnormal_trachea_morphology	1.37511466
39	MP0001764_abnormal_homeostasis	1.36697498
40	MP0005670_abnormal_white_adipose	1.35100412
41	MP0008872_abnormal_physiological_respon	1.34935605
42	MP0001485_abnormal_pinna_reflex	1.33270323
43	MP0002163_abnormal_gland_morphology	1.32497169
44	MP0002938_white_spotting	1.32275838
45	MP0008875_abnormal_xenobiotic_pharmacok	1.31716956
46	MP0002160_abnormal_reproductive_system	1.24709183
47	MP0003718_maternal_effect	1.23944481
48	MP0002277_abnormal_respiratory_mucosa	1.21126132
49	MP0000427_abnormal_hair_cycle	1.18253366
50	MP0003186_abnormal_redox_activity	1.16792193
51	MP0003045_fibrosis	1.14180916
52	MP0002210_abnormal_sex_determination	1.13883292
53	MP0010307_abnormal_tumor_latency	1.13092355
54	MP0002638_abnormal_pupillary_reflex	1.12827608
55	MP0001963_abnormal_hearing_physiology	1.11242932
56	MP0008770_decreased_survivor_rate	1.10066990
57	MP0003121_genomic_imprinting	1.09181199
58	MP0005646_abnormal_pituitary_gland	1.08952031
59	MP0003698_abnormal_male_reproductive	1.07260103
60	MP0003786_premature_aging	1.07128591
61	MP0001529_abnormal_vocalization	1.05459917
62	MP0005410_abnormal_fertilization	1.05124188
63	MP0001666_abnormal_nutrient_absorption	1.04243707
64	MP0003879_abnormal_hair_cell	1.04005576
65	MP0002111_abnormal_tail_morphology	1.02005064
66	MP0005084_abnormal_gallbladder_morpholo	1.01440210
67	MP0002733_abnormal_thermal_nociception	1.01436472
68	MP0008877_abnormal_DNA_methylation	1.01374555
69	MP0003252_abnormal_bile_duct	0.99829520
70	MP0001286_abnormal_eye_development	0.99380993
71	MP0009697_abnormal_copulation	0.98930368
72	MP0002751_abnormal_autonomic_nervous	0.97975136
73	MP0005379_endocrine/exocrine_gland_phen	0.97712368
74	MP0005195_abnormal_posterior_eye	0.96630967
75	MP0002067_abnormal_sensory_capabilities	0.96378180
76	MP0001440_abnormal_grooming_behavior	0.95938161
77	MP0005391_vision/eye_phenotype	0.95073215
78	MP0004957_abnormal_blastocyst_morpholog	0.93974824
79	MP0000653_abnormal_sex_gland	0.91806221
80	MP0000678_abnormal_parathyroid_gland	0.90917921
81	MP0003941_abnormal_skin_development	0.89720432
82	MP0002752_abnormal_somatic_nervous	0.89635571
83	MP0001486_abnormal_startle_reflex	0.88913700
84	MP0001145_abnormal_male_reproductive	0.88842010
85	MP0004924_abnormal_behavior	0.88790555
86	MP0005386_behavior/neurological_phenoty	0.88790555
87	MP0001929_abnormal_gametogenesis	0.87470389
88	MP0002177_abnormal_outer_ear	0.86594105
89	MP0005389_reproductive_system_phenotype	0.85062743
90	MP0002109_abnormal_limb_morphology	0.82722411
91	MP0005671_abnormal_response_to	0.82576402
92	MP0005075_abnormal_melanosome_morpholog	0.82129671
93	MP0001293_anophthalmia	0.81217052
94	MP0002184_abnormal_innervation	0.80433330
95	MP0003119_abnormal_digestive_system	0.79931444
96	MP0002693_abnormal_pancreas_physiology	0.79876098
97	MP0001502_abnormal_circadian_rhythm	0.79836712
98	MP0002272_abnormal_nervous_system	0.78637809
99	MP0003123_paternal_imprinting	0.75764452
100	MP0004215_abnormal_myocardial_fiber	0.75612665

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	3.95694368
2	Molar tooth sign on MRI (HP:0002419)	3.95694368
3	Congenital, generalized hypertrichosis (HP:0004540)	3.86786557
4	Reticulocytopenia (HP:0001896)	3.47470720
5	Hypochromic microcytic anemia (HP:0004840)	3.46956452
6	Genetic anticipation (HP:0003743)	3.28679357
7	Acute necrotizing encephalopathy (HP:0006965)	3.24475498
8	Bilateral microphthalmos (HP:0007633)	3.24378890
9	Mitochondrial inheritance (HP:0001427)	3.07545996
10	Nephronophthisis (HP:0000090)	3.05540326
11	Increased hepatocellular lipid droplets (HP:0006565)	2.86921596
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.82549450
13	Absent/shortened dynein arms (HP:0200106)	2.82549450
14	Abnormal number of erythroid precursors (HP:0012131)	2.80216676
15	Pendular nystagmus (HP:0012043)	2.73264879
16	Increased CSF lactate (HP:0002490)	2.70252120
17	Woolly hair (HP:0002224)	2.65942267
18	Progressive macrocephaly (HP:0004481)	2.65853898
19	3-Methylglutaconic aciduria (HP:0003535)	2.64797725
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.64499548
21	Degeneration of anterior horn cells (HP:0002398)	2.62893245
22	Abnormality of the anterior horn cell (HP:0006802)	2.62893245
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.62758739
24	Acute encephalopathy (HP:0006846)	2.57156521
25	Prostate neoplasm (HP:0100787)	2.56333969
26	Abnormality of the renal medulla (HP:0100957)	2.52023754
27	Chromsome breakage (HP:0040012)	2.50678766
28	Colon cancer (HP:0003003)	2.45963096
29	Lipid accumulation in hepatocytes (HP:0006561)	2.45671731
30	Retinal dysplasia (HP:0007973)	2.42770561
31	Abnormality of the renal cortex (HP:0011035)	2.42450289
32	Pancreatic cysts (HP:0001737)	2.42105555
33	Duplicated collecting system (HP:0000081)	2.41759539
34	Short tibia (HP:0005736)	2.41051412
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.40336755
36	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.39321441
37	Spinal muscular atrophy (HP:0007269)	2.37760718
38	Absence seizures (HP:0002121)	2.35457413
39	Abnormality of the renal collecting system (HP:0004742)	2.31909785
40	Macrocytic anemia (HP:0001972)	2.28990813
41	Congenital stationary night blindness (HP:0007642)	2.26103812
42	Progressive cerebellar ataxia (HP:0002073)	2.21494792
43	Type II lissencephaly (HP:0007260)	2.20247577
44	True hermaphroditism (HP:0010459)	2.19752204
45	Fibular aplasia (HP:0002990)	2.19676492
46	Increased corneal curvature (HP:0100692)	2.19583406
47	Keratoconus (HP:0000563)	2.19583406
48	Panhypogammaglobulinemia (HP:0003139)	2.18616617
49	Aplasia/Hypoplasia of the patella (HP:0006498)	2.17939060
50	Volvulus (HP:0002580)	2.17340195
51	Oligodactyly (hands) (HP:0001180)	2.13339390
52	Adactyly (HP:0009776)	2.12208877
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.11646965
54	Stenosis of the external auditory canal (HP:0000402)	2.09911328
55	Hepatic necrosis (HP:0002605)	2.08968199
56	Global brain atrophy (HP:0002283)	2.05816325
57	Hypomagnesemia (HP:0002917)	2.02731853
58	Tinnitus (HP:0000360)	2.00659071
59	Cerebral edema (HP:0002181)	1.99589451
60	Abolished electroretinogram (ERG) (HP:0000550)	1.98536866
61	Dialeptic seizures (HP:0011146)	1.97757821
62	Hypoplasia of the fovea (HP:0007750)	1.97056745
63	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.97056745
64	Hepatocellular necrosis (HP:0001404)	1.96930536
65	Patellar aplasia (HP:0006443)	1.94087134
66	Testicular atrophy (HP:0000029)	1.93722564
67	Abnormal drinking behavior (HP:0030082)	1.93640882
68	Polydipsia (HP:0001959)	1.93640882
69	Medial flaring of the eyebrow (HP:0010747)	1.92870948
70	Gaze-evoked nystagmus (HP:0000640)	1.92574238
71	Abnormality of the middle phalanges of the toes (HP:0010183)	1.91906651
72	Pancreatic fibrosis (HP:0100732)	1.90458225
73	Meckel diverticulum (HP:0002245)	1.90248160
74	Chronic bronchitis (HP:0004469)	1.88430483
75	Renal Fanconi syndrome (HP:0001994)	1.87203063
76	Abnormality of the ileum (HP:0001549)	1.82855531
77	IgM deficiency (HP:0002850)	1.82774122
78	Optic disc pallor (HP:0000543)	1.81893836
79	Hypoglycemic coma (HP:0001325)	1.80318860
80	Pallor (HP:0000980)	1.78695318
81	Chorioretinal coloboma (HP:0000567)	1.78664240
82	Ectopic kidney (HP:0000086)	1.78396658
83	Hypoplastic pelvis (HP:0008839)	1.78270809
84	Increased serum lactate (HP:0002151)	1.78144047
85	Renal cortical cysts (HP:0000803)	1.77483736
86	Abnormality of chromosome stability (HP:0003220)	1.74970914
87	Abnormality of the preputium (HP:0100587)	1.70794309
88	Male pseudohermaphroditism (HP:0000037)	1.69088325
89	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68044403
90	Tubular atrophy (HP:0000092)	1.67963429
91	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.67164617
92	Abnormal respiratory epithelium morphology (HP:0012253)	1.66872852
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.66872852
94	Metabolic acidosis (HP:0001942)	1.66674536
95	Exertional dyspnea (HP:0002875)	1.66571299
96	Sclerocornea (HP:0000647)	1.66263972
97	Febrile seizures (HP:0002373)	1.66216520
98	Abnormal ciliary motility (HP:0012262)	1.65402640
99	Abnormality of the prostate (HP:0008775)	1.64474586
100	Ketosis (HP:0001946)	1.62572710

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	6.33152005
2	CDK19	5.03239442
3	FRK	3.07047101
4	VRK1	3.02307927
5	TAF1	2.93623892
6	NUAK1	2.41551899
7	OXSR1	2.30372010
8	EPHB2	2.18682447
9	SIK3	2.13584220
10	BUB1	1.99461936
11	PLK3	1.89401647
12	STK24	1.89311470
13	GRK1	1.74565277
14	ZAK	1.72771241
15	TAOK3	1.69821574
16	CHEK2	1.66856946
17	TXK	1.64571546
18	TYRO3	1.52645818
19	TLK1	1.49709619
20	STK3	1.46173967
21	WNK3	1.45694953
22	CDC7	1.44153702
23	PLK4	1.41861416
24	ADRBK2	1.41032611
25	NEK1	1.37044597
26	MST4	1.36370614
27	TEC	1.29420542
28	TTK	1.25671988
29	STK38L	1.20747622
30	MAPK15	1.12454586
31	NEK2	1.12052430
32	MARK3	1.11274221
33	PASK	1.10369813
34	UHMK1	1.10064241
35	CASK	1.09464154
36	SRPK1	1.05705653
37	WEE1	1.03176853
38	TSSK6	1.00871818
39	IRAK4	1.00868824
40	TNK2	0.96373034
41	MAP3K9	0.95429119
42	BMPR1B	0.91485680
43	WNK4	0.90186871
44	IRAK1	0.89568747
45	EIF2AK2	0.89363729
46	BCR	0.87070954
47	MKNK1	0.81540173
48	AURKB	0.78131370
49	INSRR	0.77706047
50	SIK2	0.73603987
51	DYRK2	0.73555070
52	STK39	0.68706880
53	NME1	0.68562273
54	ACVR1B	0.67527501
55	GRK5	0.67471316
56	MKNK2	0.66483814
57	MAP2K6	0.64746905
58	TNIK	0.64522322
59	STK16	0.64344455
60	MAPKAPK5	0.63382883
61	PINK1	0.63023536
62	ADRBK1	0.62714341
63	ITK	0.61923297
64	PRKCG	0.60730543
65	MAPK13	0.59398231
66	PTK2B	0.58669836
67	EIF2AK1	0.57349570
68	FGFR2	0.56287451
69	SMG1	0.55773535
70	TIE1	0.54848312
71	OBSCN	0.54734165
72	EIF2AK3	0.53716112
73	CDK4	0.50073996
74	ATR	0.49965340
75	CSNK1G2	0.48567590
76	FGR	0.46795464
77	CSNK1G3	0.46352133
78	TGFBR1	0.44068019
79	KSR1	0.42657207
80	PDK2	0.42167908
81	BTK	0.41987954
82	ATM	0.41124310
83	PHKG2	0.39989629
84	PHKG1	0.39989629
85	DYRK1B	0.39196030
86	BRSK2	0.35777642
87	IRAK2	0.35012078
88	BMX	0.34982379
89	PLK1	0.34936864
90	PRKACB	0.34683385
91	CHUK	0.32700365
92	CSNK2A1	0.31387925
93	CSNK1G1	0.30639090
94	NTRK2	0.29656637
95	CSNK1E	0.28810043
96	MOS	0.28604847
97	CSNK1A1L	0.28585991
98	CCNB1	0.27061713
99	CDK18	0.26239466
100	CHEK1	0.26204340

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.40695224
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.27225197
3	Protein export_Homo sapiens_hsa03060	3.24474995
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.76188880
5	Parkinsons disease_Homo sapiens_hsa05012	2.47236343
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45868811
7	RNA polymerase_Homo sapiens_hsa03020	2.23169031
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15664875
9	Butanoate metabolism_Homo sapiens_hsa00650	2.10351854
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04950672
11	Basal transcription factors_Homo sapiens_hsa03022	2.01836068
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.94605744
13	Caffeine metabolism_Homo sapiens_hsa00232	1.93015423
14	Mismatch repair_Homo sapiens_hsa03430	1.87743186
15	Homologous recombination_Homo sapiens_hsa03440	1.84861706
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.84838912
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84292832
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82660421
19	Huntingtons disease_Homo sapiens_hsa05016	1.82342442
20	Spliceosome_Homo sapiens_hsa03040	1.80823849
21	Alzheimers disease_Homo sapiens_hsa05010	1.71240548
22	Proteasome_Homo sapiens_hsa03050	1.68264797
23	Sulfur relay system_Homo sapiens_hsa04122	1.67354696
24	One carbon pool by folate_Homo sapiens_hsa00670	1.64542105
25	Propanoate metabolism_Homo sapiens_hsa00640	1.62366555
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56350451
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.52921209
28	RNA degradation_Homo sapiens_hsa03018	1.50322237
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49422235
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43812833
31	Phototransduction_Homo sapiens_hsa04744	1.40245339
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.31627534
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.30504834
34	Primary immunodeficiency_Homo sapiens_hsa05340	1.28149544
35	DNA replication_Homo sapiens_hsa03030	1.27970673
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.23175382
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.22487220
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22121857
39	Sulfur metabolism_Homo sapiens_hsa00920	1.18225575
40	Taste transduction_Homo sapiens_hsa04742	1.14533684
41	Nicotine addiction_Homo sapiens_hsa05033	1.09436891
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08681018
43	Base excision repair_Homo sapiens_hsa03410	1.07979061
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04460421
45	Purine metabolism_Homo sapiens_hsa00230	1.00926716
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00233088
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96622390
48	RNA transport_Homo sapiens_hsa03013	0.96068149
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95405204
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.94115574
51	Olfactory transduction_Homo sapiens_hsa04740	0.90991789
52	Folate biosynthesis_Homo sapiens_hsa00790	0.90082776
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88438311
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.86947790
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.86834494
56	Regulation of autophagy_Homo sapiens_hsa04140	0.86587988
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.86227066
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84420273
59	Retinol metabolism_Homo sapiens_hsa00830	0.84336246
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84105648
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81783151
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77918894
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75344846
64	Circadian rhythm_Homo sapiens_hsa04710	0.71139700
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68575354
66	p53 signaling pathway_Homo sapiens_hsa04115	0.66734834
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64879114
68	Glutathione metabolism_Homo sapiens_hsa00480	0.64277431
69	Fatty acid degradation_Homo sapiens_hsa00071	0.62302226
70	Antigen processing and presentation_Homo sapiens_hsa04612	0.61448248
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59996771
72	Metabolic pathways_Homo sapiens_hsa01100	0.59317197
73	GABAergic synapse_Homo sapiens_hsa04727	0.52059490
74	Morphine addiction_Homo sapiens_hsa05032	0.51300983
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.49368759
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46372857
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.46359127
78	Peroxisome_Homo sapiens_hsa04146	0.45267241
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42545160
80	Cell cycle_Homo sapiens_hsa04110	0.39985358
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39074523
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.37755537
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36864194
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.36202968
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.34908363
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30626376
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30594477
88	Tight junction_Homo sapiens_hsa04530	0.29165005
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.27971754
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27097565
91	Mineral absorption_Homo sapiens_hsa04978	0.25778198
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.25410653
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.25359503
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25046887
95	Oocyte meiosis_Homo sapiens_hsa04114	0.23483608
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.22051168
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.21896108
98	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.21545080
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.20903584
100	Insulin secretion_Homo sapiens_hsa04911	0.20365188

DDX10P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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