DDX11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.89117449
2DNA unwinding involved in DNA replication (GO:0006268)4.73061537
3DNA strand elongation involved in DNA replication (GO:0006271)4.59515220
4regulation of translational fidelity (GO:0006450)4.55827963
5DNA replication initiation (GO:0006270)4.50621176
6protein localization to chromosome, centromeric region (GO:0071459)4.43024875
7telomere maintenance via semi-conservative replication (GO:0032201)4.39936439
8DNA strand elongation (GO:0022616)4.36877968
9nuclear pore organization (GO:0006999)4.35239773
10nuclear pore complex assembly (GO:0051292)4.34599167
11mitotic sister chromatid segregation (GO:0000070)4.32795767
12DNA synthesis involved in DNA repair (GO:0000731)4.20458718
13kinetochore organization (GO:0051383)4.10886335
14sister chromatid segregation (GO:0000819)4.08220179
15mitotic metaphase plate congression (GO:0007080)4.05123152
16DNA replication checkpoint (GO:0000076)4.02987768
17telomere maintenance via recombination (GO:0000722)4.00117089
18mitotic recombination (GO:0006312)3.96439196
19mitotic chromosome condensation (GO:0007076)3.91997491
20chromatin remodeling at centromere (GO:0031055)3.87085396
21CENP-A containing nucleosome assembly (GO:0034080)3.83483014
22DNA replication-dependent nucleosome assembly (GO:0006335)3.83145666
23DNA replication-dependent nucleosome organization (GO:0034723)3.83145666
24metaphase plate congression (GO:0051310)3.82498503
25mitotic nuclear envelope disassembly (GO:0007077)3.80962627
26meiotic chromosome segregation (GO:0045132)3.79500135
27regulation of RNA export from nucleus (GO:0046831)3.78513488
28attachment of spindle microtubules to kinetochore (GO:0008608)3.77563209
29negative regulation of mRNA metabolic process (GO:1903312)3.75313180
30protein-DNA complex disassembly (GO:0032986)3.74496030
31nucleosome disassembly (GO:0006337)3.74496030
32spliceosomal tri-snRNP complex assembly (GO:0000244)3.73480839
33telomere maintenance via telomere lengthening (GO:0010833)3.72214517
34kinetochore assembly (GO:0051382)3.68389483
35folic acid-containing compound biosynthetic process (GO:0009396)3.65271137
36DNA packaging (GO:0006323)3.62370118
37* DNA duplex unwinding (GO:0032508)3.62285057
38* DNA geometric change (GO:0032392)3.61569522
39establishment of chromosome localization (GO:0051303)3.55187191
40DNA replication-independent nucleosome assembly (GO:0006336)3.54998869
41DNA replication-independent nucleosome organization (GO:0034724)3.54998869
42regulation of DNA damage checkpoint (GO:2000001)3.53779966
43chromatin assembly (GO:0031497)3.50177837
44membrane disassembly (GO:0030397)3.49581020
45nuclear envelope disassembly (GO:0051081)3.49581020
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.44871206
47positive regulation of cell cycle checkpoint (GO:1901978)3.44393318
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.43119491
49viral mRNA export from host cell nucleus (GO:0046784)3.41786929
50regulation of histone H3-K9 methylation (GO:0051570)3.37409171
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34771741
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34648343
53IMP biosynthetic process (GO:0006188)3.34154398
54mitotic sister chromatid cohesion (GO:0007064)3.29963588
55pore complex assembly (GO:0046931)3.29766187
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28531549
57regulation of spindle organization (GO:0090224)3.28242815
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26732763
59nuclear envelope organization (GO:0006998)3.24194693
60histone exchange (GO:0043486)3.23711256
61pre-miRNA processing (GO:0031054)3.21449577
62mismatch repair (GO:0006298)3.20808646
63regulation of centriole replication (GO:0046599)3.19795325
64chromatin assembly or disassembly (GO:0006333)3.19099191
65regulation of cell cycle checkpoint (GO:1901976)3.17114082
66* DNA conformation change (GO:0071103)3.14513422
67RNA stabilization (GO:0043489)3.14457382
68mRNA stabilization (GO:0048255)3.14457382
69V(D)J recombination (GO:0033151)3.12582177
70regulation of nucleobase-containing compound transport (GO:0032239)3.12576464
71regulation of histone H3-K4 methylation (GO:0051569)3.12237141
72ribosomal small subunit biogenesis (GO:0042274)3.11891394
73telomere maintenance (GO:0000723)3.11769251
74regulation of telomere maintenance via telomerase (GO:0032210)3.11281128
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.10686971
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10686971
77protein localization to chromosome (GO:0034502)3.10359610
78mRNA transport (GO:0051028)3.09709258
79regulation of double-strand break repair via homologous recombination (GO:0010569)3.09618525
80telomere organization (GO:0032200)3.08770663
81regulation of centrosome duplication (GO:0010824)3.07884996
82negative regulation of chromosome segregation (GO:0051985)3.07570206
83protein complex localization (GO:0031503)3.07213310
84nucleobase biosynthetic process (GO:0046112)3.06952204
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06684201
86spindle assembly checkpoint (GO:0071173)3.05187068
87regulation of chromosome segregation (GO:0051983)3.05108173
88chromosome segregation (GO:0007059)3.03740782
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.02249118
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02249118
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02249118
92negative regulation of sister chromatid segregation (GO:0033046)3.02249118
93ribosomal small subunit assembly (GO:0000028)3.01424857
94protein K6-linked ubiquitination (GO:0085020)3.01255634
95dosage compensation (GO:0007549)3.00751567
96maturation of SSU-rRNA (GO:0030490)3.00381716
97spindle checkpoint (GO:0031577)3.00140674
98IMP metabolic process (GO:0046040)2.99736883
99positive regulation of DNA-dependent DNA replication (GO:2000105)2.99224331
100heterochromatin organization (GO:0070828)2.97740806
101formation of translation preinitiation complex (GO:0001731)2.97305883
102DNA topological change (GO:0006265)2.96734550
103folic acid metabolic process (GO:0046655)2.96517811
104mRNA export from nucleus (GO:0006406)2.96467583
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96348033
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95446982
107regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95392718
108double-strand break repair via nonhomologous end joining (GO:0006303)2.94841322
109non-recombinational repair (GO:0000726)2.94841322
110regulation of centrosome cycle (GO:0046605)2.94655386
111mitotic spindle assembly checkpoint (GO:0007094)2.94125813
112negative regulation of histone methylation (GO:0031061)2.94091117
113base-excision repair (GO:0006284)2.94088304
114regulation of histone H3-K27 methylation (GO:0061085)2.92928898
115regulation of mitotic spindle organization (GO:0060236)2.92630675
116regulation of spindle checkpoint (GO:0090231)2.90780346
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90292349
118RNA export from nucleus (GO:0006405)2.90286140
119DNA ligation (GO:0006266)2.89549548
120DNA replication (GO:0006260)2.88812670
121translesion synthesis (GO:0019985)2.88770520
122mitotic G1 DNA damage checkpoint (GO:0031571)2.88292361
123ATP-dependent chromatin remodeling (GO:0043044)2.87777248
124regulation of double-strand break repair (GO:2000779)2.84813878
125positive regulation of chromosome segregation (GO:0051984)2.84312139
126L-serine metabolic process (GO:0006563)2.83571770
127intra-S DNA damage checkpoint (GO:0031573)2.83428302
128regulation of DNA-dependent DNA replication (GO:0090329)2.83316666
129regulation of mitotic sister chromatid separation (GO:0010965)2.83263463
130regulation of mitotic sister chromatid segregation (GO:0033047)2.83263463
131regulation of sister chromatid segregation (GO:0033045)2.83263463
132negative regulation of RNA splicing (GO:0033119)2.83069754
133regulation of sister chromatid cohesion (GO:0007063)2.82716678
134proline biosynthetic process (GO:0006561)2.81871447
135chromosome condensation (GO:0030261)2.81799291
136negative regulation of cell cycle G2/M phase transition (GO:1902750)2.81746491
137microtubule depolymerization (GO:0007019)2.81589191
138mitotic spindle checkpoint (GO:0071174)2.81207193
139mRNA cleavage (GO:0006379)2.80578314
140G1 DNA damage checkpoint (GO:0044783)2.80508114
141establishment of integrated proviral latency (GO:0075713)2.79470340
142regulation of histone methylation (GO:0031060)2.78853072
143ribosome biogenesis (GO:0042254)2.78050050
144DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74214073
145negative regulation of mRNA processing (GO:0050686)2.73665361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.48360421
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32254392
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.79107434
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.73521786
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87012203
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75899627
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65657487
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53238879
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.48799640
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39731036
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31286076
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.21019136
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.18013012
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16428891
15AR_21909140_ChIP-Seq_LNCAP_Human2.14280290
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12153402
17XRN2_22483619_ChIP-Seq_HELA_Human2.00895451
18E2F7_22180533_ChIP-Seq_HELA_Human10.2398461
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96199579
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96064142
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.94916304
22MYC_22102868_ChIP-Seq_BL_Human1.94075344
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92894254
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.91445661
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91095930
26VDR_23849224_ChIP-Seq_CD4+_Human1.84415692
27FOXP3_21729870_ChIP-Seq_TREG_Human1.83301548
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81984824
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79014997
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78629519
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.78562361
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77510696
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74741927
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73685951
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73099539
36CIITA_25753668_ChIP-Seq_RAJI_Human1.71902592
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70936673
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70616997
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64518160
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62918592
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62443698
42TTF2_22483619_ChIP-Seq_HELA_Human1.61057782
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56400233
44DCP1A_22483619_ChIP-Seq_HELA_Human1.55838512
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46104989
46GABP_19822575_ChIP-Seq_HepG2_Human1.45578811
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43834066
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.42346521
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41810965
50KDM5A_27292631_Chip-Seq_BREAST_Human1.40225414
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38613779
52TCF7_22412390_ChIP-Seq_EML_Mouse1.33860476
53LXR_22292898_ChIP-Seq_THP-1_Human1.33606269
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33012634
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31680338
56ELK1_19687146_ChIP-ChIP_HELA_Human1.31016817
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30985480
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30930207
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29430717
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29164584
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28828253
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.28688340
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28194619
64VDR_21846776_ChIP-Seq_THP-1_Human1.28123137
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.27503212
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26714335
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26237640
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26174967
69ZNF263_19887448_ChIP-Seq_K562_Human1.22525600
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22435953
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22090981
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20964800
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20384055
74RACK7_27058665_Chip-Seq_MCF-7_Human1.20119736
75* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18361126
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17623944
77KDM2B_26808549_Chip-Seq_DND41_Human1.17578095
78P68_20966046_ChIP-Seq_HELA_Human1.17089670
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15252020
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13761642
81NCOR1_26117541_ChIP-Seq_K562_Human1.11952245
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11922128
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11615695
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06851042
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06851042
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06851042
87PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06346239
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.05860783
89MAF_26560356_Chip-Seq_TH2_Human1.05078498
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04253355
91SPI1_23547873_ChIP-Seq_NB4_Human1.03976066
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02972023
93MAF_26560356_Chip-Seq_TH1_Human1.02358717
94* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02250630
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.00186859
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99826508
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98808350
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.98645296
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98531795
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97250430
101UTX_26944678_Chip-Seq_JUKART_Human0.97167385
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96634971
103TFEB_21752829_ChIP-Seq_HELA_Human0.96609382
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96205519
105CHD1_26751641_Chip-Seq_LNCaP_Human0.95450201
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94383218
107* MYC_18940864_ChIP-ChIP_HL60_Human0.92867861
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92485560
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92115179
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89125191
111SCL_19346495_ChIP-Seq_HPC-7_Human0.89005390
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88912983
113SMC4_20622854_ChIP-Seq_HELA_Human0.88863877
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88243039
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88172183
116MYB_26560356_Chip-Seq_TH1_Human0.87547415
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87242722
118CREB1_26743006_Chip-Seq_LNCaP_Human0.87015989
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86370756
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84073032
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.83834700
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83353568
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.83251699
124* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83110645
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.83022779
126TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82445717
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82226652
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.82092906
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81826086
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81703229
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81205862
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78205653
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77471677
134MYB_26560356_Chip-Seq_TH2_Human0.76162662
135MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.75070657
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74975537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.59081133
2MP0003693_abnormal_embryo_hatching4.40131852
3* MP0003111_abnormal_nucleus_morphology4.35295579
4MP0008057_abnormal_DNA_replication4.01301107
5* MP0003077_abnormal_cell_cycle3.72388444
6MP0004957_abnormal_blastocyst_morpholog3.65269174
7MP0008058_abnormal_DNA_repair3.10825899
8MP0002396_abnormal_hematopoietic_system2.83525972
9MP0008007_abnormal_cellular_replicative2.66196843
10MP0003705_abnormal_hypodermis_morpholog2.22746025
11* MP0008932_abnormal_embryonic_tissue2.22547675
12MP0010352_gastrointestinal_tract_polyps2.16554316
13MP0000350_abnormal_cell_proliferation2.10726148
14MP0004185_abnormal_adipocyte_glucose2.06265948
15MP0000490_abnormal_crypts_of2.05267636
16MP0008877_abnormal_DNA_methylation2.00360475
17MP0004808_abnormal_hematopoietic_stem1.94528403
18MP0001730_embryonic_growth_arrest1.83471782
19MP0010030_abnormal_orbit_morphology1.81754776
20MP0010307_abnormal_tumor_latency1.79761648
21MP0003123_paternal_imprinting1.77271775
22MP0003786_premature_aging1.75600356
23MP0009672_abnormal_birth_weight1.69955456
24MP0000537_abnormal_urethra_morphology1.68804731
25* MP0001672_abnormal_embryogenesis/_devel1.66217700
26* MP0005380_embryogenesis_phenotype1.66217700
27MP0003121_genomic_imprinting1.60159228
28MP0004233_abnormal_muscle_weight1.57896461
29MP0006292_abnormal_olfactory_placode1.57316825
30MP0003763_abnormal_thymus_physiology1.55638523
31MP0002009_preneoplasia1.53710249
32MP0001849_ear_inflammation1.50240093
33MP0002877_abnormal_melanocyte_morpholog1.49369525
34MP0001697_abnormal_embryo_size1.47815162
35MP0003890_abnormal_embryonic-extraembry1.47633432
36MP0002085_abnormal_embryonic_tissue1.47488329
37MP0002019_abnormal_tumor_incidence1.46557525
38MP0000313_abnormal_cell_death1.45750314
39MP0001545_abnormal_hematopoietic_system1.44834496
40MP0005397_hematopoietic_system_phenotyp1.44834496
41* MP0003984_embryonic_growth_retardation1.44497051
42* MP0002088_abnormal_embryonic_growth/wei1.40919666
43* MP0002086_abnormal_extraembryonic_tissu1.36965871
44MP0002084_abnormal_developmental_patter1.36764590
45MP0000703_abnormal_thymus_morphology1.36640196
46MP0000566_synostosis1.36527446
47MP0001346_abnormal_lacrimal_gland1.35243451
48* MP0002080_prenatal_lethality1.35241318
49MP0001293_anophthalmia1.33137920
50MP0002697_abnormal_eye_size1.32226437
51MP0001661_extended_life_span1.31968950
52MP0002398_abnormal_bone_marrow1.31934873
53MP0002210_abnormal_sex_determination1.30346299
54MP0004197_abnormal_fetal_growth/weight/1.29734966
55MP0005075_abnormal_melanosome_morpholog1.24815814
56MP0003718_maternal_effect1.24706995
57MP0009278_abnormal_bone_marrow1.22632029
58MP0000003_abnormal_adipose_tissue1.20805593
59MP0002722_abnormal_immune_system1.20587366
60MP0005076_abnormal_cell_differentiation1.19278306
61MP0000678_abnormal_parathyroid_gland1.16270350
62MP0000689_abnormal_spleen_morphology1.13906331
63MP0005451_abnormal_body_composition1.13656291
64MP0002089_abnormal_postnatal_growth/wei1.13343077
65MP0001929_abnormal_gametogenesis1.12356496
66MP0001145_abnormal_male_reproductive1.09061994
67MP0009333_abnormal_splenocyte_physiolog1.06814273
68MP0000685_abnormal_immune_system1.04858407
69MP0008995_early_reproductive_senescence1.04243667
70MP0002132_abnormal_respiratory_system1.00782711
71MP0002429_abnormal_blood_cell0.98604736
72MP0003567_abnormal_fetal_cardiomyocyte0.97828654
73MP0005501_abnormal_skin_physiology0.96798270
74MP0001800_abnormal_humoral_immune0.96010695
75MP0000428_abnormal_craniofacial_morphol0.94561424
76MP0001119_abnormal_female_reproductive0.94124785
77MP0002653_abnormal_ependyma_morphology0.94086173
78MP0000653_abnormal_sex_gland0.92942981
79MP0000716_abnormal_immune_system0.92281662
80MP0000858_altered_metastatic_potential0.92129530
81MP0003941_abnormal_skin_development0.90655342
82MP0001835_abnormal_antigen_presentation0.89187061
83MP0005174_abnormal_tail_pigmentation0.88425186
84MP0005666_abnormal_adipose_tissue0.88317736
85MP0001348_abnormal_lacrimal_gland0.88268829
86MP0003115_abnormal_respiratory_system0.88158129
87MP0004133_heterotaxia0.88009284
88MP0004264_abnormal_extraembryonic_tissu0.87717164
89MP0005671_abnormal_response_to0.85773896
90MP0006035_abnormal_mitochondrial_morpho0.85755904
91MP0002970_abnormal_white_adipose0.84841967
92MP0005220_abnormal_exocrine_pancreas0.84304510
93MP0002102_abnormal_ear_morphology0.83954798
94MP0000358_abnormal_cell_content/0.81955788
95MP0002092_abnormal_eye_morphology0.81844754
96MP0003861_abnormal_nervous_system0.80959743
97MP0002420_abnormal_adaptive_immunity0.80936160
98MP0003937_abnormal_limbs/digits/tail_de0.80861551
99MP0002075_abnormal_coat/hair_pigmentati0.80275826
100MP0002249_abnormal_larynx_morphology0.79660018
101MP0002452_abnormal_antigen_presenting0.79613734
102MP0001819_abnormal_immune_cell0.79137781
103MP0002405_respiratory_system_inflammati0.78964298
104MP0003787_abnormal_imprinting0.78829202
105MP0010155_abnormal_intestine_physiology0.77912344
106MP0003699_abnormal_female_reproductive0.77874664
107MP0002095_abnormal_skin_pigmentation0.77294675
108MP0002114_abnormal_axial_skeleton0.76268079
109MP0000579_abnormal_nail_morphology0.75952092
110MP0000371_diluted_coat_color0.75633033
111MP0001873_stomach_inflammation0.74814141
112MP0002111_abnormal_tail_morphology0.74527263
113MP0000733_abnormal_muscle_development0.74275617
114MP0005023_abnormal_wound_healing0.72072575
115MP0005083_abnormal_biliary_tract0.71949206
116MP0003385_abnormal_body_wall0.71518761
117MP0002098_abnormal_vibrissa_morphology0.70986327
118MP0001286_abnormal_eye_development0.70949739
119MP0005375_adipose_tissue_phenotype0.70703195
120MP0001915_intracranial_hemorrhage0.70470951
121MP0009697_abnormal_copulation0.69602840
122MP0000477_abnormal_intestine_morphology0.69377841
123MP0003119_abnormal_digestive_system0.69367162
124MP0003453_abnormal_keratinocyte_physiol0.68622574
125MP0003436_decreased_susceptibility_to0.68038554
126MP0002723_abnormal_immune_serum0.67107811
127MP0004381_abnormal_hair_follicle0.66288933
128MP0005384_cellular_phenotype0.66286640
129MP0003942_abnormal_urinary_system0.66231737
130MP0003315_abnormal_perineum_morphology0.66191499
131MP0005621_abnormal_cell_physiology0.65297006
132MP0000465_gastrointestinal_hemorrhage0.64674967
133MP0004858_abnormal_nervous_system0.63789813
134MP0000049_abnormal_middle_ear0.62852995
135MP0003943_abnormal_hepatobiliary_system0.62186270
136MP0000432_abnormal_head_morphology0.61609086
137MP0003698_abnormal_male_reproductive0.61144976
138MP0001186_pigmentation_phenotype0.61064619
139MP0009703_decreased_birth_body0.60634613

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.31914876
2Chromsome breakage (HP:0040012)5.31099227
3Reticulocytopenia (HP:0001896)3.85981298
4Birth length less than 3rd percentile (HP:0003561)3.80761473
5Abnormality of chromosome stability (HP:0003220)3.71961930
6Meckel diverticulum (HP:0002245)3.62143861
7Abnormality of the preputium (HP:0100587)3.55994255
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.55318281
9Abnormality of the ileum (HP:0001549)3.52310062
10Medulloblastoma (HP:0002885)3.35642069
11Hyperacusis (HP:0010780)3.25755141
12Microvesicular hepatic steatosis (HP:0001414)3.24540633
13Ependymoma (HP:0002888)3.19270719
14Myelodysplasia (HP:0002863)3.16251406
15Duodenal stenosis (HP:0100867)3.07808756
16Small intestinal stenosis (HP:0012848)3.07808756
17Impulsivity (HP:0100710)2.96531983
18Ectopic kidney (HP:0000086)2.89041680
19Selective tooth agenesis (HP:0001592)2.86211216
20Colon cancer (HP:0003003)2.81280840
21Increased nuchal translucency (HP:0010880)2.76255312
22Abnormality of the carotid arteries (HP:0005344)2.75059988
23Aplastic anemia (HP:0001915)2.70798054
24Duplicated collecting system (HP:0000081)2.70547695
25Progressive muscle weakness (HP:0003323)2.69982790
26Urethral obstruction (HP:0000796)2.68768880
27Rhabdomyosarcoma (HP:0002859)2.67881594
28Agnosia (HP:0010524)2.67626774
29Absent radius (HP:0003974)2.66953862
30Clubbing of toes (HP:0100760)2.62103497
31Absent thumb (HP:0009777)2.61413347
32* Sloping forehead (HP:0000340)2.61093615
33Abnormality of the duodenum (HP:0002246)2.57134480
34Bone marrow hypocellularity (HP:0005528)2.55175827
35Patellar aplasia (HP:0006443)2.55155484
36Abnormality of DNA repair (HP:0003254)2.53914616
37Supernumerary spleens (HP:0009799)2.52397992
38Nephroblastoma (Wilms tumor) (HP:0002667)2.52158147
39Aplasia involving forearm bones (HP:0009822)2.49212825
40Absent forearm bone (HP:0003953)2.49212825
41Abnormality of the renal collecting system (HP:0004742)2.49087854
42Oral leukoplakia (HP:0002745)2.43737030
43Broad distal phalanx of finger (HP:0009836)2.43243973
44Abnormality of the anterior horn cell (HP:0006802)2.42960728
45Degeneration of anterior horn cells (HP:0002398)2.42960728
46Abnormality of cells of the erythroid lineage (HP:0012130)2.40697936
47Abnormality of the calcaneus (HP:0008364)2.39074864
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.37402512
49Absent epiphyses (HP:0010577)2.37402512
50Ulnar bowing (HP:0003031)2.36232320
51Aplasia/Hypoplasia of the patella (HP:0006498)2.34640261
52Embryonal renal neoplasm (HP:0011794)2.34615743
53Abnormal number of erythroid precursors (HP:0012131)2.34443735
54Long eyelashes (HP:0000527)2.33642692
55Abnormal lung lobation (HP:0002101)2.32873758
56Abnormal number of incisors (HP:0011064)2.32665871
57Progressive external ophthalmoplegia (HP:0000590)2.32526062
58Volvulus (HP:0002580)2.31765877
59Breast hypoplasia (HP:0003187)2.31443209
60Triphalangeal thumb (HP:0001199)2.31314685
61Tracheoesophageal fistula (HP:0002575)2.27270967
62Neoplasm of striated muscle (HP:0009728)2.26214377
63Intestinal fistula (HP:0100819)2.25991038
64Flared metaphyses (HP:0003015)2.21655552
65Metaphyseal cupping (HP:0003021)2.20167718
6611 pairs of ribs (HP:0000878)2.20116740
67Basal cell carcinoma (HP:0002671)2.18348704
68Overlapping toe (HP:0001845)2.14436727
69Abnormality of reticulocytes (HP:0004312)2.13181763
70Duplication of thumb phalanx (HP:0009942)2.11727883
71Broad face (HP:0000283)2.10678039
72Abnormality of pyrimidine metabolism (HP:0004353)2.10568889
73Ureteral duplication (HP:0000073)2.09103454
74Abnormality of the astrocytes (HP:0100707)2.08586969
75Astrocytoma (HP:0009592)2.08586969
76Cafe-au-lait spot (HP:0000957)2.08025327
77Pallor (HP:0000980)2.07894721
78Thrombocytosis (HP:0001894)2.07402580
79Flat acetabular roof (HP:0003180)2.06900034
80Long palpebral fissure (HP:0000637)2.06555047
81Neoplasm of the oral cavity (HP:0100649)2.06548984
82Prominent nose (HP:0000448)2.06307864
83Heterotopia (HP:0002282)2.04619221
84Glioma (HP:0009733)2.03852475
85Insomnia (HP:0100785)2.02279893
86Pseudobulbar signs (HP:0002200)1.99359302
87Atresia of the external auditory canal (HP:0000413)1.98584836
88Disproportionate tall stature (HP:0001519)1.97437709
89Deep palmar crease (HP:0006191)1.96926910
90Sandal gap (HP:0001852)1.96889960
91Abnormality of the fingertips (HP:0001211)1.96066078
92Lymphoma (HP:0002665)1.92428285
93Short thumb (HP:0009778)1.91694414
94Premature graying of hair (HP:0002216)1.91583744
95Proximal placement of thumb (HP:0009623)1.90837785
96Neoplasm of the pancreas (HP:0002894)1.89817166
97Facial hemangioma (HP:0000329)1.89726897
98Obsessive-compulsive behavior (HP:0000722)1.88995071
99Leukopenia (HP:0001882)1.88968160
100Trigonocephaly (HP:0000243)1.88858218
101Septate vagina (HP:0001153)1.88291838
102Dysmetric saccades (HP:0000641)1.86928158
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.84970254
104Deviation of the thumb (HP:0009603)1.84432558
105Choanal atresia (HP:0000453)1.84260028
106Pointed chin (HP:0000307)1.84257176
107Ragged-red muscle fibers (HP:0003200)1.84135809
108Poikiloderma (HP:0001029)1.83487112
109Abnormality of the labia minora (HP:0012880)1.83085145
110Asplenia (HP:0001746)1.82595399
111Horseshoe kidney (HP:0000085)1.82106107
112Amaurosis fugax (HP:0100576)1.80607474
113Abnormality of chromosome segregation (HP:0002916)1.80564171
114Elfin facies (HP:0004428)1.79287057
115Abnormality of the thoracic spine (HP:0100711)1.79220422
116Acute lymphatic leukemia (HP:0006721)1.78509357
117Missing ribs (HP:0000921)1.78163373
118Rib fusion (HP:0000902)1.77242276
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77088805
120Short 4th metacarpal (HP:0010044)1.77088805
121Preauricular skin tag (HP:0000384)1.77001896
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76944327
123Broad palm (HP:0001169)1.76289210
124Cellular immunodeficiency (HP:0005374)1.76098729
125Broad thumb (HP:0011304)1.75498437
126Renal duplication (HP:0000075)1.75474662
127Deep philtrum (HP:0002002)1.75289073
128High pitched voice (HP:0001620)1.75117203
129Anal stenosis (HP:0002025)1.74954994
130Squamous cell carcinoma (HP:0002860)1.73998029
131Overriding aorta (HP:0002623)1.73881892
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.73062828
133Ankyloglossia (HP:0010296)1.73043018
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72636351
135Abdominal situs inversus (HP:0003363)1.72411202
136Abnormality of abdominal situs (HP:0011620)1.72411202
137Premature ovarian failure (HP:0008209)1.72394140
138Rough bone trabeculation (HP:0100670)1.70558905
139IgM deficiency (HP:0002850)1.69917711
140Arteriovenous malformation (HP:0100026)1.69701874
141Self-mutilation (HP:0000742)1.69448874
142Multiple enchondromatosis (HP:0005701)1.69334047
143Broad phalanges of the hand (HP:0009768)1.68816478
144Dislocated radial head (HP:0003083)1.68619097
145Gastrointestinal carcinoma (HP:0002672)1.66159413
146Malignant gastrointestinal tract tumors (HP:0006749)1.66159413
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.65993606
148Acute myeloid leukemia (HP:0004808)1.65928876
149High anterior hairline (HP:0009890)1.65918836
150Neoplasm of the colon (HP:0100273)1.63828979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59416384
2CDC74.33186874
3TRIB34.11303231
4SMG13.54914241
5NEK23.45914095
6CDK123.43528762
7WEE13.25565772
8ICK3.00410134
9TTK2.89628489
10EEF2K2.18043429
11SRPK12.17423653
12PLK12.09498733
13CDK72.07896334
14ATR2.07291187
15MST1R2.00283288
16STK101.93726632
17EIF2AK11.79720390
18TLK11.78389812
19AURKB1.77739078
20RPS6KB21.77046554
21CDK41.76929201
22CHEK21.75561590
23MAP3K101.71530607
24MAP4K11.69176407
25MKNK11.65271968
26PASK1.56170513
27VRK11.53687956
28PLK41.51370505
29TSSK61.48586643
30BRD41.40014677
31SIK11.39942961
32STK41.39808566
33CHEK11.39635336
34PRPF4B1.36743396
35CDK81.35106934
36DYRK31.31653012
37MAP3K81.31399504
38MKNK21.31359691
39ACVR1B1.31082092
40BRSK21.29682681
41NME21.29144527
42NEK11.28216119
43RPS6KA41.23287767
44VRK21.15797088
45FLT31.14216307
46FGFR41.13136040
47ATM1.11295066
48CAMK1D1.10338828
49CAMK1G1.05499644
50STK161.05334954
51TXK1.05244457
52CDK61.04953992
53TGFBR11.04540025
54NME11.04033349
55PLK31.03291637
56AURKA1.02133817
57ERN11.01617696
58GRK61.01543247
59SIK21.00934301
60PIM11.00545171
61ZAK0.99805618
62EPHA20.95155708
63CDK20.94018127
64EIF2AK20.93736987
65PAK40.92331936
66YES10.86306618
67MET0.85120988
68BTK0.84807120
69CSF1R0.84511033
70PBK0.83331508
71EIF2AK30.83153424
72PKN20.82915995
73MELK0.81346493
74MAP2K20.78530014
75MAP3K130.75163432
76CLK10.74948538
77STK30.74740546
78TESK20.74409945
79JAK30.74066932
80BRSK10.71297391
81KIT0.68761032
82BMX0.68554584
83ZAP700.67695113
84CDK10.67550120
85MAP2K30.66992808
86TYRO30.65834088
87MTOR0.61640981
88ALK0.59550141
89TAF10.58551075
90BRAF0.54753273
91CHUK0.53829132
92CCNB10.52979731
93SCYL20.52860105
94TEC0.50296822
95CSNK2A20.50068215
96RPS6KC10.50032250
97RPS6KL10.50032250
98AKT20.49831590
99MAP3K70.49612869
100CSNK2A10.48283049
101CDK90.47893295
102MATK0.46438570
103TYK20.45507548
104TTN0.44046556
105GSK3B0.43861704
106RPS6KA10.42679180
107PDGFRA0.42565111
108WNK40.42356824
109TGFBR20.41194694
110RPS6KA60.38270528
111IKBKB0.38023163
112MAPK110.37754994
113TAOK20.37722395
114RAF10.37544609
115MAPKAPK30.37278771
116PTK60.36714645
117MAP3K60.36072575
118MAPK140.34784516
119IRAK20.34693677
120FGFR20.34291636
121FGFR30.34238454
122PAK10.34054169
123NLK0.34007964
124PRKDC0.33842138
125LRRK20.33327081
126KDR0.33318238
127RPS6KA50.32860989
128PRKD30.32608146
129LYN0.32238443
130AKT10.31217086
131CDC42BPA0.30756225
132LCK0.30364225
133RIPK10.29985955
134PNCK0.29120680
135LATS10.28964863
136MAPK100.28167442
137MAPK10.28112954
138CSNK1E0.27373459
139PRKCI0.26295027
140IRAK30.26089353

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04357212
2Mismatch repair_Homo sapiens_hsa034304.28189275
3Base excision repair_Homo sapiens_hsa034103.43456349
4Homologous recombination_Homo sapiens_hsa034403.36713938
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21760370
6Fanconi anemia pathway_Homo sapiens_hsa034603.02843901
7Spliceosome_Homo sapiens_hsa030403.00731583
8One carbon pool by folate_Homo sapiens_hsa006702.99539607
9Cell cycle_Homo sapiens_hsa041102.81872296
10RNA transport_Homo sapiens_hsa030132.80632928
11Nucleotide excision repair_Homo sapiens_hsa034202.68850769
12Ribosome_Homo sapiens_hsa030102.40872226
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40300164
14Non-homologous end-joining_Homo sapiens_hsa034502.27562013
15RNA polymerase_Homo sapiens_hsa030202.10743284
16Pyrimidine metabolism_Homo sapiens_hsa002401.99224503
17RNA degradation_Homo sapiens_hsa030181.95967297
18mRNA surveillance pathway_Homo sapiens_hsa030151.90478094
19Basal transcription factors_Homo sapiens_hsa030221.85397713
20p53 signaling pathway_Homo sapiens_hsa041151.61884283
21Systemic lupus erythematosus_Homo sapiens_hsa053221.48739766
22Proteasome_Homo sapiens_hsa030501.37065616
23Herpes simplex infection_Homo sapiens_hsa051681.29977003
24Viral carcinogenesis_Homo sapiens_hsa052031.12993572
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10849821
26Primary immunodeficiency_Homo sapiens_hsa053401.10614864
27Epstein-Barr virus infection_Homo sapiens_hsa051691.05699115
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02353461
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99064823
30Purine metabolism_Homo sapiens_hsa002300.97739480
31HTLV-I infection_Homo sapiens_hsa051660.95742651
32Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95351545
33Antigen processing and presentation_Homo sapiens_hsa046120.93883780
34MicroRNAs in cancer_Homo sapiens_hsa052060.92987262
35Notch signaling pathway_Homo sapiens_hsa043300.91585273
36Carbon metabolism_Homo sapiens_hsa012000.82307513
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.81896083
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81652861
39Small cell lung cancer_Homo sapiens_hsa052220.80474255
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80175230
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79190365
42Measles_Homo sapiens_hsa051620.75955897
43Selenocompound metabolism_Homo sapiens_hsa004500.75813743
44Thyroid cancer_Homo sapiens_hsa052160.73695916
45mTOR signaling pathway_Homo sapiens_hsa041500.71583074
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71108380
47Oocyte meiosis_Homo sapiens_hsa041140.70560857
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69916262
49Endometrial cancer_Homo sapiens_hsa052130.69838928
50Glioma_Homo sapiens_hsa052140.69532617
51Chronic myeloid leukemia_Homo sapiens_hsa052200.68240325
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67782637
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.67359471
54Basal cell carcinoma_Homo sapiens_hsa052170.66658491
55Apoptosis_Homo sapiens_hsa042100.64982560
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.64884677
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64653089
58Pentose phosphate pathway_Homo sapiens_hsa000300.63302925
59Lysine degradation_Homo sapiens_hsa003100.62361771
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60732416
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.60161477
62Legionellosis_Homo sapiens_hsa051340.60071405
63Galactose metabolism_Homo sapiens_hsa000520.59120600
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.58001018
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57949876
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57804890
67ErbB signaling pathway_Homo sapiens_hsa040120.57406034
68Hematopoietic cell lineage_Homo sapiens_hsa046400.57105067
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57097036
70Hepatitis B_Homo sapiens_hsa051610.56796673
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55540492
72Influenza A_Homo sapiens_hsa051640.54834535
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53055894
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52866847
75AMPK signaling pathway_Homo sapiens_hsa041520.52619359
76Colorectal cancer_Homo sapiens_hsa052100.51955262
77Acute myeloid leukemia_Homo sapiens_hsa052210.51535245
78VEGF signaling pathway_Homo sapiens_hsa043700.51349351
79Sulfur relay system_Homo sapiens_hsa041220.51092150
80Biosynthesis of amino acids_Homo sapiens_hsa012300.50478103
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50313272
82Folate biosynthesis_Homo sapiens_hsa007900.49984435
83Insulin signaling pathway_Homo sapiens_hsa049100.48653326
84Vitamin B6 metabolism_Homo sapiens_hsa007500.48240318
85Alcoholism_Homo sapiens_hsa050340.47327930
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.44050831
87B cell receptor signaling pathway_Homo sapiens_hsa046620.43490630
88Arginine biosynthesis_Homo sapiens_hsa002200.42858569
89Bladder cancer_Homo sapiens_hsa052190.42667100
90Wnt signaling pathway_Homo sapiens_hsa043100.41249163
91Pathways in cancer_Homo sapiens_hsa052000.40705132
92Shigellosis_Homo sapiens_hsa051310.40163950
93Choline metabolism in cancer_Homo sapiens_hsa052310.39542038
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39066998
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38409206
96TGF-beta signaling pathway_Homo sapiens_hsa043500.38130149
97Viral myocarditis_Homo sapiens_hsa054160.38119600
98Leishmaniasis_Homo sapiens_hsa051400.37865803
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36524208
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36399876
101Hippo signaling pathway_Homo sapiens_hsa043900.33958706
102Inositol phosphate metabolism_Homo sapiens_hsa005620.33749508
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33088011
104Pancreatic cancer_Homo sapiens_hsa052120.32926470
105Fructose and mannose metabolism_Homo sapiens_hsa000510.32140916
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.31748961
107Prostate cancer_Homo sapiens_hsa052150.31286357
108Non-small cell lung cancer_Homo sapiens_hsa052230.30303846
109T cell receptor signaling pathway_Homo sapiens_hsa046600.30197657
110Melanoma_Homo sapiens_hsa052180.30002682
111Glucagon signaling pathway_Homo sapiens_hsa049220.28450290
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28409822
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28397078
114N-Glycan biosynthesis_Homo sapiens_hsa005100.28108181
115Adherens junction_Homo sapiens_hsa045200.26876235
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26766833
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.26094391
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25090019
119Pyruvate metabolism_Homo sapiens_hsa006200.24637301
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23989266
121Hedgehog signaling pathway_Homo sapiens_hsa043400.21676742
122HIF-1 signaling pathway_Homo sapiens_hsa040660.20319228
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17643580
124Toxoplasmosis_Homo sapiens_hsa051450.17611859
125TNF signaling pathway_Homo sapiens_hsa046680.17345819
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17133694
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16904972
128Glutathione metabolism_Homo sapiens_hsa004800.16729266
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16542020
130Other glycan degradation_Homo sapiens_hsa005110.16016232

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