DDX11L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.25165788
2protein neddylation (GO:0045116)8.12664183
3neutrophil activation involved in immune response (GO:0002283)7.30864239
4adenosine receptor signaling pathway (GO:0001973)6.99556628
5regulation of platelet aggregation (GO:0090330)6.14932959
6G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.09480821
7regulation of platelet activation (GO:0010543)5.74955338
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.62170089
9purinergic nucleotide receptor signaling pathway (GO:0035590)5.59695660
10blood coagulation, intrinsic pathway (GO:0007597)5.42578488
11platelet aggregation (GO:0070527)5.26368934
12leukocyte migration involved in inflammatory response (GO:0002523)5.21668625
13regulation of integrin-mediated signaling pathway (GO:2001044)5.20558380
14negative regulation of norepinephrine secretion (GO:0010700)4.93990349
15positive regulation of mast cell activation (GO:0033005)4.71047802
16negative regulation of homotypic cell-cell adhesion (GO:0034111)4.64411374
17megakaryocyte development (GO:0035855)4.61091491
18negative regulation of platelet activation (GO:0010544)4.57087560
19lipoxygenase pathway (GO:0019372)4.55288130
20purinergic receptor signaling pathway (GO:0035587)4.53088773
21negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.50490099
22positive regulation of endothelial cell differentiation (GO:0045603)4.42236024
23regulation of Golgi to plasma membrane protein transport (GO:0042996)4.37668361
24G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.30901055
25angiogenesis involved in wound healing (GO:0060055)4.30438922
26neutrophil activation (GO:0042119)4.26016675
27fusion of sperm to egg plasma membrane (GO:0007342)4.22621782
28regulation of lipoprotein metabolic process (GO:0050746)4.22401698
29negative regulation of heart rate (GO:0010459)4.17976113
30negative regulation of thymocyte apoptotic process (GO:0070244)4.15685650
31regulation of integrin activation (GO:0033623)4.12534853
32negative regulation of protein localization to cell surface (GO:2000009)4.08458064
33low-density lipoprotein particle remodeling (GO:0034374)4.01338389
34platelet degranulation (GO:0002576)3.94456730
35positive regulation of systemic arterial blood pressure (GO:0003084)3.87348080
36granulocyte activation (GO:0036230)3.86359239
37platelet formation (GO:0030220)3.85285387
38positive regulation of cAMP-mediated signaling (GO:0043950)3.75713287
39positive regulation of macrophage differentiation (GO:0045651)3.66027257
40platelet activation (GO:0030168)3.66021378
41homotypic cell-cell adhesion (GO:0034109)3.64466706
42negative regulation of response to food (GO:0032096)3.59538437
43negative regulation of appetite (GO:0032099)3.59538437
44regulation of homotypic cell-cell adhesion (GO:0034110)3.55206737
45negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.55093500
46positive regulation of Rho protein signal transduction (GO:0035025)3.49538951
47positive regulation of blood coagulation (GO:0030194)3.41641486
48positive regulation of hemostasis (GO:1900048)3.41641486
49regulation of macrophage derived foam cell differentiation (GO:0010743)3.39376427
50polyamine biosynthetic process (GO:0006596)3.38485494
51regulation of MHC class II biosynthetic process (GO:0045346)3.37199088
52autophagic vacuole fusion (GO:0000046)3.36512613
53negative regulation of neural precursor cell proliferation (GO:2000178)3.32211650
54regulation of norepinephrine secretion (GO:0014061)3.24469600
55leukocyte degranulation (GO:0043299)3.23726514
56positive regulation of receptor recycling (GO:0001921)3.22163528
57high-density lipoprotein particle remodeling (GO:0034375)3.21586715
58regulation of female receptivity (GO:0045924)3.20828300
59negative regulation of heart contraction (GO:0045822)3.19439888
60negative regulation of T-helper cell differentiation (GO:0045623)3.18893324
61negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18893324
62regulation of memory T cell differentiation (GO:0043380)3.17778122
63positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.17386822
64regulation of mast cell activation (GO:0033003)3.14632554
65microtubule depolymerization (GO:0007019)3.12829689
66termination of G-protein coupled receptor signaling pathway (GO:0038032)3.12631410
67mitochondrial calcium ion transport (GO:0006851)3.10742569
68beta-amyloid metabolic process (GO:0050435)3.08170393
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04027287
70termination of signal transduction (GO:0023021)3.03192232
71plasma membrane fusion (GO:0045026)3.02487319
72positive regulation of coagulation (GO:0050820)3.02052913
73regulation of T-helper 1 cell differentiation (GO:0045625)3.01336021
74extracellular fibril organization (GO:0043206)2.97344384
75positive regulation of granulocyte differentiation (GO:0030854)2.96995013
76reverse cholesterol transport (GO:0043691)2.96375522
77fatty acid elongation (GO:0030497)2.95286941
78negative regulation of catecholamine secretion (GO:0033604)2.95281272
79regulation of mast cell degranulation (GO:0043304)2.94260969
80regulation of endothelial cell differentiation (GO:0045601)2.94237408
81regulation of skeletal muscle contraction (GO:0014819)2.94169069
82negative regulation of protein localization to plasma membrane (GO:1903077)2.92875386
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92184133
84negative regulation of calcium ion transport into cytosol (GO:0010523)2.91227274
85negative regulation of T cell apoptotic process (GO:0070233)2.90958953
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.90216228
87positive regulation of mast cell degranulation (GO:0043306)2.90216228
88positive regulation of protein homodimerization activity (GO:0090073)2.89017413
89pyrimidine nucleoside catabolic process (GO:0046135)2.85989998
90regulation of blood coagulation (GO:0030193)2.85300870
91regulation of hemostasis (GO:1900046)2.85300870
92endothelium development (GO:0003158)2.84706060
93regulation of mast cell activation involved in immune response (GO:0033006)2.82601355
94regulation of cholesterol efflux (GO:0010874)2.82577878
95cyclooxygenase pathway (GO:0019371)2.82186856
96regulation of megakaryocyte differentiation (GO:0045652)2.79625652
97regulation of regulatory T cell differentiation (GO:0045589)2.78714237
98vesicle targeting (GO:0006903)2.77678911
99long-chain fatty acid biosynthetic process (GO:0042759)2.77611341
100peptide catabolic process (GO:0043171)2.77076025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human5.01406608
2SCL_19346495_ChIP-Seq_HPC-7_Human4.69135047
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.26391213
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57019916
5GATA1_19941826_ChIP-Seq_K562_Human3.45357414
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.38316432
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.26264658
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.85318778
9GATA1_19941827_ChIP-Seq_MEL_Mouse2.78904538
10GATA2_19941826_ChIP-Seq_K562_Human2.73442437
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72975583
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.64116062
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.61811189
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.49078076
15GATA1_22383799_ChIP-Seq_G1ME_Mouse2.44586391
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.42556189
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35282156
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.33301722
19GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.30675598
20SPI1_23127762_ChIP-Seq_K562_Human2.29448251
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.28772239
22GATA1_22025678_ChIP-Seq_K562_Human2.25438504
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.18297734
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.11556093
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09142063
26ELK4_26923725_Chip-Seq_MESODERM_Mouse2.08572991
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07772762
28HTT_18923047_ChIP-ChIP_STHdh_Human1.96329705
29GATA1_19941827_ChIP-Seq_MEL86_Mouse1.88995882
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77714609
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74960855
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67784584
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67522097
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.63123905
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57999904
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57390568
37UTX_26944678_Chip-Seq_JUKART_Human1.53428373
38GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50308796
39NCOR1_26117541_ChIP-Seq_K562_Human1.48328560
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46037624
41VDR_24763502_ChIP-Seq_THP-1_Human1.44138255
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42399704
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41035913
44TAF15_26573619_Chip-Seq_HEK293_Human1.40268634
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32295739
46GBX2_23144817_ChIP-Seq_PC3_Human1.28556256
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24505901
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23946731
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22850556
50MAF_26560356_Chip-Seq_TH1_Human1.22711001
51ETS1_22383799_ChIP-Seq_G1ME_Mouse1.22609784
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21598253
53SPI1_20517297_ChIP-Seq_HL60_Human1.20949646
54EZH2_22144423_ChIP-Seq_EOC_Human1.18408194
55RUNX_20019798_ChIP-Seq_JUKART_Human1.17826652
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16698772
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14753768
58SPI1_23547873_ChIP-Seq_NB4_Human1.13433894
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12911251
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11311493
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10632401
62BCL6_27268052_Chip-Seq_Bcells_Human1.09897502
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08245860
64BCOR_27268052_Chip-Seq_Bcells_Human1.07862818
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07353325
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06985262
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03892486
68CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03304235
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.01624940
70SALL4_22934838_ChIP-ChIP_CD34+_Human1.01508153
71NANOG_20526341_ChIP-Seq_ESCs_Human0.99900170
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98503178
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98179668
74GATA3_27048872_Chip-Seq_THYMUS_Human0.97752527
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97099172
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96856092
77CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96579900
78EWS_26573619_Chip-Seq_HEK293_Human0.96516551
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95777811
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93517947
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92329292
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92329292
83TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89270023
84CTCF_21964334_Chip-Seq_Bcells_Human0.88478783
85P68_20966046_ChIP-Seq_HELA_Human0.87784836
86TCF7_22412390_ChIP-Seq_EML_Mouse0.86134828
87STAT1_20625510_ChIP-Seq_HELA_Human0.86111780
88IRF8_22096565_ChIP-ChIP_GC-B_Human0.86023116
89GATA3_26560356_Chip-Seq_TH2_Human0.85721749
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85165079
91MYB_26560356_Chip-Seq_TH2_Human0.85121085
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83683814
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83657121
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82859047
95LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81547647
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79730345
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79402111
98OCT1_27270436_Chip-Seq_PROSTATE_Human0.76506535
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75678688
100VDR_21846776_ChIP-Seq_THP-1_Human0.75295303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.41062560
2MP0008004_abnormal_stomach_pH4.99965238
3MP0003724_increased_susceptibility_to3.49335786
4MP0000465_gastrointestinal_hemorrhage3.20341953
5MP0005083_abnormal_biliary_tract2.85767760
6MP0003303_peritoneal_inflammation2.76417108
7MP0004510_myositis2.45920231
8MP0002736_abnormal_nociception_after2.44782201
9MP0005174_abnormal_tail_pigmentation2.30884021
10MP0003136_yellow_coat_color2.28816920
11MP0005084_abnormal_gallbladder_morpholo2.22946276
12MP0001835_abnormal_antigen_presentation2.20575462
13MP0000343_altered_response_to2.14344559
14MP0000230_abnormal_systemic_arterial2.05877762
15MP0005171_absent_coat_pigmentation2.05236045
16MP0004130_abnormal_muscle_cell1.92204109
17MP0005409_darkened_coat_color1.90977643
18MP0001968_abnormal_touch/_nociception1.90500672
19MP0004084_abnormal_cardiac_muscle1.83163938
20MP0005410_abnormal_fertilization1.81523856
21MP0003566_abnormal_cell_adhesion1.69488554
22MP0001986_abnormal_taste_sensitivity1.66748349
23MP0008775_abnormal_heart_ventricle1.66416512
24MP0000015_abnormal_ear_pigmentation1.65333732
25MP0002148_abnormal_hypersensitivity_rea1.63349262
26MP0010155_abnormal_intestine_physiology1.61778154
27MP0005167_abnormal_blood-brain_barrier1.61488129
28MP0003828_pulmonary_edema1.56660356
29MP0005058_abnormal_lysosome_morphology1.51904905
30MP0002398_abnormal_bone_marrow1.49664338
31MP0003638_abnormal_response/metabolism_1.49237687
32MP0008872_abnormal_physiological_respon1.45522172
33MP0005397_hematopoietic_system_phenotyp1.44349587
34MP0001545_abnormal_hematopoietic_system1.44349587
35MP0005671_abnormal_response_to1.42879371
36MP0005000_abnormal_immune_tolerance1.42228656
37MP0001851_eye_inflammation1.33307524
38MP0001663_abnormal_digestive_system1.33048173
39MP0005646_abnormal_pituitary_gland1.31534486
40MP0004947_skin_inflammation1.30287120
41MP0003879_abnormal_hair_cell1.29513916
42MP0002132_abnormal_respiratory_system1.27624967
43MP0004036_abnormal_muscle_relaxation1.26111725
44MP0003436_decreased_susceptibility_to1.24372763
45MP0001879_abnormal_lymphatic_vessel1.23302336
46MP0002723_abnormal_immune_serum1.16532797
47MP0000249_abnormal_blood_vessel1.16251554
48MP0010329_abnormal_lipoprotein_level1.14811351
49MP0001664_abnormal_digestion1.13653810
50MP0001756_abnormal_urination1.10007807
51MP0000858_altered_metastatic_potential1.08332893
52MP0002429_abnormal_blood_cell1.07447137
53MP0000689_abnormal_spleen_morphology1.07074074
54MP0009763_increased_sensitivity_to1.06702733
55MP0002452_abnormal_antigen_presenting1.05419441
56MP0002733_abnormal_thermal_nociception1.05317127
57MP0001800_abnormal_humoral_immune1.05270083
58MP0001765_abnormal_ion_homeostasis1.04637766
59MP0004381_abnormal_hair_follicle1.04147867
60MP0003656_abnormal_erythrocyte_physiolo1.01545266
61MP0008874_decreased_physiological_sensi0.96832355
62MP0004215_abnormal_myocardial_fiber0.96073989
63MP0002722_abnormal_immune_system0.95267359
64MP0009642_abnormal_blood_homeostasis0.94878308
65MP0006276_abnormal_autonomic_nervous0.94557438
66MP0009764_decreased_sensitivity_to0.93468536
67MP0002420_abnormal_adaptive_immunity0.92720678
68MP0001533_abnormal_skeleton_physiology0.92441089
69MP0001819_abnormal_immune_cell0.91123229
70MP0003453_abnormal_keratinocyte_physiol0.88600878
71MP0000716_abnormal_immune_system0.87755795
72MP0009333_abnormal_splenocyte_physiolog0.86621661
73MP0002735_abnormal_chemical_nociception0.86205751
74MP0001970_abnormal_pain_threshold0.85908042
75MP0005666_abnormal_adipose_tissue0.84375517
76MP0005501_abnormal_skin_physiology0.84109873
77MP0001845_abnormal_inflammatory_respons0.83755388
78MP0002419_abnormal_innate_immunity0.82078068
79MP0003866_abnormal_defecation0.80609689
80MP0005381_digestive/alimentary_phenotyp0.79018467
81MP0009278_abnormal_bone_marrow0.77959848
82MP0005025_abnormal_response_to0.75868245
83MP0005423_abnormal_somatic_nervous0.74122395
84MP0005535_abnormal_body_temperature0.73986669
85MP0003718_maternal_effect0.73982574
86MP0003045_fibrosis0.73390662
87MP0009765_abnormal_xenobiotic_induced0.73237983
88MP0005023_abnormal_wound_healing0.71395799
89MP0002118_abnormal_lipid_homeostasis0.68979357
90MP0004484_altered_response_of0.68820507
91MP0005385_cardiovascular_system_phenoty0.68815171
92MP0001544_abnormal_cardiovascular_syste0.68815171
93MP0001661_extended_life_span0.68269002
94MP0001188_hyperpigmentation0.68062720
95MP0003448_altered_tumor_morphology0.67823027
96MP0004808_abnormal_hematopoietic_stem0.67231074
97MP0006054_spinal_hemorrhage0.66811930
98MP0000358_abnormal_cell_content/0.64503639
99MP0000685_abnormal_immune_system0.64219643
100MP0002972_abnormal_cardiac_muscle0.64011058

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.88138481
2Petechiae (HP:0000967)9.68091814
3Abnormal platelet volume (HP:0011876)9.34033252
4Purpura (HP:0000979)8.42798742
5Epistaxis (HP:0000421)7.76962098
6Gingival bleeding (HP:0000225)6.64917631
7Dyschromatopsia (HP:0007641)6.22129126
8Hyperlipoproteinemia (HP:0010980)5.90968492
9Impaired platelet aggregation (HP:0003540)5.73722456
10Abnormal platelet function (HP:0011869)5.73722456
11Poikilocytosis (HP:0004447)4.50915773
12Acanthocytosis (HP:0001927)4.39422846
13Spontaneous hematomas (HP:0007420)4.07837505
14Abnormality of the common coagulation pathway (HP:0010990)3.98496838
15Decreased central vision (HP:0007663)3.83273984
16Bruising susceptibility (HP:0000978)3.50871995
17Abnormal pupillary function (HP:0007686)3.43102858
18Joint hemorrhage (HP:0005261)3.37470894
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.29672687
20Paralysis (HP:0003470)3.27019949
21Conjunctival telangiectasia (HP:0000524)3.10008231
22Abnormality of the vasculature of the conjunctiva (HP:0008054)2.75282187
23Tinnitus (HP:0000360)2.71606786
24Abnormal auditory evoked potentials (HP:0006958)2.69795571
25Male infertility (HP:0003251)2.69196260
26Spontaneous abortion (HP:0005268)2.59947820
27Abnormality of lateral ventricle (HP:0030047)2.57117343
28Increased density of long bones (HP:0006392)2.53142268
29Generalized aminoaciduria (HP:0002909)2.39591400
30Upper limb muscle weakness (HP:0003484)2.38657833
31Abnormality of iron homeostasis (HP:0011031)2.35971425
32Xanthomatosis (HP:0000991)2.34496871
33Joint swelling (HP:0001386)2.33639187
34Hepatosplenomegaly (HP:0001433)2.28116300
35Hypophosphatemic rickets (HP:0004912)2.25201089
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15307077
37Stomatitis (HP:0010280)2.14163187
38Abnormality of macrophages (HP:0004311)2.10609022
39Increased IgM level (HP:0003496)2.06096456
40Abnormality of transition element cation homeostasis (HP:0011030)2.05556413
41Arterial thrombosis (HP:0004420)2.05267328
42Papillary thyroid carcinoma (HP:0002895)2.04519609
43Prolonged bleeding time (HP:0003010)11.2679278
44Menorrhagia (HP:0000132)10.1120841
45Rectovaginal fistula (HP:0000143)1.99038296
46Rectal fistula (HP:0100590)1.99038296
47Attenuation of retinal blood vessels (HP:0007843)1.97652204
48Thyroid-stimulating hormone excess (HP:0002925)1.88303502
49Nausea (HP:0002018)1.87937286
50Autoimmune hemolytic anemia (HP:0001890)1.84658646
51Renal Fanconi syndrome (HP:0001994)1.83268403
52Thrombocytosis (HP:0001894)1.80918735
53Increased serum ferritin (HP:0003281)1.80369973
54Intestinal fistula (HP:0100819)1.76271046
55Hyperthyroidism (HP:0000836)1.73638506
56Encephalitis (HP:0002383)1.72519080
57Episodic fever (HP:0001954)1.71603197
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67849806
59Abnormality of alanine metabolism (HP:0010916)1.67623126
60Hyperalaninemia (HP:0003348)1.67623126
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67623126
623-Methylglutaconic aciduria (HP:0003535)1.66376346
63Hemorrhage of the eye (HP:0011885)1.63100655
64Biliary tract neoplasm (HP:0100574)1.62721920
65Basal ganglia calcification (HP:0002135)1.62277823
66Chronic obstructive pulmonary disease (HP:0006510)1.61105335
67Obstructive lung disease (HP:0006536)1.61105335
68Infertility (HP:0000789)1.60025198
69Vaginal fistula (HP:0004320)1.59665837
70Facial diplegia (HP:0001349)1.59100601
71Tongue fasciculations (HP:0001308)1.57989508
72Abnormality of the costochondral junction (HP:0000919)1.56676446
73Chest pain (HP:0100749)1.54992277
74Abnormality of the intrinsic pathway (HP:0010989)1.54649958
75Dysautonomia (HP:0002459)1.53016855
76Choroideremia (HP:0001139)1.52460124
77Exertional dyspnea (HP:0002875)1.50592431
78Abnormality of the prostate (HP:0008775)1.49802139
79Abnormal ciliary motility (HP:0012262)1.49250778
80Testicular neoplasm (HP:0010788)1.49205596
81Abnormality of the hepatic vasculature (HP:0006707)1.48193193
82Ventricular fibrillation (HP:0001663)1.48176242
83Vertigo (HP:0002321)1.46779614
84Polycythemia (HP:0001901)1.46346198
85Muscle fibrillation (HP:0010546)1.45764195
86Myocardial infarction (HP:0001658)1.45093669
87Congenital stationary night blindness (HP:0007642)1.45030414
88Hypertriglyceridemia (HP:0002155)1.43256691
89Polyphagia (HP:0002591)1.40845509
90Ileus (HP:0002595)1.39372353
91Distal lower limb amyotrophy (HP:0008944)1.39240878
92Central scotoma (HP:0000603)1.38905095
93Thrombophlebitis (HP:0004418)1.37051949
94Dysostosis multiplex (HP:0000943)1.35920154
95Poikiloderma (HP:0001029)1.34920686
96Uterine leiomyosarcoma (HP:0002891)1.32218632
97Leiomyosarcoma (HP:0100243)1.32218632
98Facial hemangioma (HP:0000329)1.32011283
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.31701990
100Congenital sensorineural hearing impairment (HP:0008527)1.30225010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.10992929
2MST44.77464593
3BMX4.31191136
4MYLK3.51420438
5BTK3.11692425
6TEC3.08341393
7EIF2AK12.87127932
8PTK2B2.54449403
9TAOK32.43448376
10SYK2.38099402
11ZAP702.26417910
12CSF1R2.24372214
13ACVR1B2.22068452
14PIK3CG2.21009553
15GRK62.16089480
16BMPR21.93220359
17GRK51.92140017
18STK31.88573867
19BLK1.75990090
20ILK1.68912212
21HCK1.52244479
22ADRBK21.52109419
23MAP2K31.50340469
24FGR1.35107055
25TNK21.33384855
26TESK21.30933943
27FES1.29035469
28TLK11.22489815
29NUAK11.18429791
30LYN1.17480416
31PAK11.13882872
32BMPR1B1.12583779
33MAPKAPK31.12348107
34IKBKB1.12009988
35MAPK151.05041706
36ADRBK11.04928994
37TNIK1.02990816
38LMTK21.02460867
39DAPK31.00808050
40IRAK10.99402124
41MATK0.97123887
42TXK0.95658487
43PNCK0.93330283
44ITK0.90819432
45WNK40.90817351
46PDPK10.87109037
47SIK30.85433699
48PLK20.83184562
49RET0.82781560
50PRKD10.81843382
51STK240.79633655
52PDK10.79153613
53CSK0.76407134
54TRIM280.75579098
55MAP3K50.73877719
56IRAK20.72266486
57DAPK20.71711980
58PIM20.71271356
59MAPK120.66995987
60MARK30.65453134
61MAP4K20.60566393
62MAP2K10.60146783
63ZAK0.55799724
64STK40.53051340
65ERBB20.51830016
66EPHA30.51719663
67LCK0.51416131
68PRKACG0.50886971
69TAOK20.47884160
70FER0.43987186
71PKN10.43858077
72IRAK30.40858964
73MINK10.40328760
74PRKG10.40328259
75PRKCQ0.40233232
76MUSK0.39868790
77JAK30.37364618
78FYN0.36240481
79PDGFRB0.36097645
80MAP3K30.35715142
81DAPK10.35042044
82CDK140.32475630
83SGK20.32156355
84PRKCD0.31131545
85MAP4K10.29245674
86MAPK130.28942846
87JAK20.28231701
88PRKCA0.26138024
89SRC0.24487835
90PRKCB0.24484586
91SGK30.24234350
92CAMKK20.23831140
93IRAK40.23413293
94MAPK110.23264214
95GRK10.23247376
96DYRK1B0.22861631
97ROCK10.21326076
98PIM10.21201421
99HIPK20.20897092
100YES10.18507105

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.65691198
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.28760846
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.03336494
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.49961856
5Hematopoietic cell lineage_Homo sapiens_hsa046402.44353466
6Nitrogen metabolism_Homo sapiens_hsa009102.27382140
7ECM-receptor interaction_Homo sapiens_hsa045122.06739760
8Arachidonic acid metabolism_Homo sapiens_hsa005902.06470844
9Gap junction_Homo sapiens_hsa045402.02143021
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78992422
11Chemokine signaling pathway_Homo sapiens_hsa040621.76345188
12Serotonergic synapse_Homo sapiens_hsa047261.64956790
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.60523747
14Alcoholism_Homo sapiens_hsa050341.57466291
15Systemic lupus erythematosus_Homo sapiens_hsa053221.55539281
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51940707
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50870021
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48666684
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39723339
20Endocytosis_Homo sapiens_hsa041441.38074796
21B cell receptor signaling pathway_Homo sapiens_hsa046621.31072605
22Collecting duct acid secretion_Homo sapiens_hsa049661.30286925
23Glycerolipid metabolism_Homo sapiens_hsa005611.28688156
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17698360
25Pancreatic secretion_Homo sapiens_hsa049721.13561667
26Shigellosis_Homo sapiens_hsa051311.12813800
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09710616
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08911377
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05067157
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.04673810
31Linoleic acid metabolism_Homo sapiens_hsa005911.04015861
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00500779
33Long-term depression_Homo sapiens_hsa047300.96329942
34Sulfur relay system_Homo sapiens_hsa041220.95965750
35T cell receptor signaling pathway_Homo sapiens_hsa046600.94250247
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.93987392
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88878992
38Olfactory transduction_Homo sapiens_hsa047400.88197488
39Glycosaminoglycan degradation_Homo sapiens_hsa005310.88061172
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84108361
41Malaria_Homo sapiens_hsa051440.83245552
42Circadian entrainment_Homo sapiens_hsa047130.81069578
43Calcium signaling pathway_Homo sapiens_hsa040200.80880359
44Sulfur metabolism_Homo sapiens_hsa009200.80873616
45Sphingolipid metabolism_Homo sapiens_hsa006000.77837336
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76656788
47Morphine addiction_Homo sapiens_hsa050320.76338949
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75787654
49Fatty acid elongation_Homo sapiens_hsa000620.75415056
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75392540
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73527841
52Primary immunodeficiency_Homo sapiens_hsa053400.73497471
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72941572
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.72876499
55Choline metabolism in cancer_Homo sapiens_hsa052310.72480473
56Pancreatic cancer_Homo sapiens_hsa052120.70058120
57Glutathione metabolism_Homo sapiens_hsa004800.69781097
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.68262609
59Phagosome_Homo sapiens_hsa041450.67943476
60Focal adhesion_Homo sapiens_hsa045100.66912598
61Osteoclast differentiation_Homo sapiens_hsa043800.65512909
62Rap1 signaling pathway_Homo sapiens_hsa040150.64746278
63Phototransduction_Homo sapiens_hsa047440.64318999
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62798130
65Fat digestion and absorption_Homo sapiens_hsa049750.59883268
66Non-small cell lung cancer_Homo sapiens_hsa052230.58613490
67Viral carcinogenesis_Homo sapiens_hsa052030.57759804
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55671175
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55668517
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55278231
71Renin-angiotensin system_Homo sapiens_hsa046140.55275333
72Staphylococcus aureus infection_Homo sapiens_hsa051500.53956344
73Ras signaling pathway_Homo sapiens_hsa040140.53369021
74Cholinergic synapse_Homo sapiens_hsa047250.48591566
75Starch and sucrose metabolism_Homo sapiens_hsa005000.47566810
76ABC transporters_Homo sapiens_hsa020100.47484274
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45660845
78Melanoma_Homo sapiens_hsa052180.44334153
79VEGF signaling pathway_Homo sapiens_hsa043700.44222583
80Mismatch repair_Homo sapiens_hsa034300.44040228
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.43822830
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41929708
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.40412163
84Small cell lung cancer_Homo sapiens_hsa052220.39825162
85Endometrial cancer_Homo sapiens_hsa052130.39777968
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38960043
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37343493
88Steroid biosynthesis_Homo sapiens_hsa001000.37274949
89Apoptosis_Homo sapiens_hsa042100.36858263
90Ovarian steroidogenesis_Homo sapiens_hsa049130.36803712
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36569021
92Renin secretion_Homo sapiens_hsa049240.36506383
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35844108
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35362240
95GABAergic synapse_Homo sapiens_hsa047270.35217520
96Chemical carcinogenesis_Homo sapiens_hsa052040.34876399
97Asthma_Homo sapiens_hsa053100.33004582
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32527480
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32259981
100Salmonella infection_Homo sapiens_hsa051320.32225313

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